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The Center for Structural Genomics of Infectious Diseases is a consortium of laboratories using state-of-the-art structural biology methods to determine the 3-D structures of proteins from major human pathogens (see Overview for more detailed information about our mission).

July 2010: The CSGID has determined its 200th protein structure.


 February 2010: Protein determined by CSGID featured as the NIAID structure of the month.

November 2009: Protein determined by CSGID featured as the NIAID structure of the month.


August 13th, 2009: The CSGID has determined its 100th protein structure. For more information, read our press releases: (Northwestern University) (University of Virginia)

The laboratories participating in the CSGID are:

Northwestern University

University of Chicago

J. Craig Venter Institute

University College London

University of Toronto

University of Virginia

UT Southwestern Medical Center at Dallas

Washington University School of Medicine

Targets: 5028
Targets requested by the community: 932
Targets with structures: 184
Structures: 225
Structures complexed with ligands: 57
Structures requested by the community: 50
Publications: 11


Target IDP00348    200th structure
Title: 1.95 Angstrom crystal structure of a bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase (aroA) from Listeria monocytogenes EGD-e
Authors: Halavaty, A.S. Light, S.H. Minasov, G. Shuvalova, L. Kwon, K. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP00167    community request
Title: Crystal structure of pre-cleavage form of cysteine protease domain from Vibrio cholerae RtxA toxin
Authors: Shuvalova, L., Minasov, G., Prochazkova, K., Satchell, K.J.F., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90163    community request
Title: Crystal Structure of Type I 3-Dehydroquinate Dehydratase (aroD) from Clostridium difficile with Covalent Reaction Intermediate.
Authors: Minasov, G., Light, S.H., Shuvalova, L., Dubrovska, I., Winsor, J., Peterson, S.N., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID).





Target IDP90224    community request
Title: Structure of the type III effector/phosphothreonine lyase OspF from Shigella flexneri
Authors: Singer A.U., Skarina T., Nocek B., Gordon R., Lam R., Kagan O., Edwards A.M., Joachimiak A., Chirgadze N.Y., Anderson W.F., Savchenko A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90225    community request
Title: Structure of a putative YscO homolog CT670 from Chlamydia trachomatis
Authors: Lam, R., Singer, A., Skarina, T., Onopriyenko, O., Bochkarev, A., Brunzelle, J.S., Edwards, A.M., Anderson, W.F., Chirgadze, N.Y., Savchenko, A.





Target IDP90258    community request
Title: 2.35 Angstrom resolution crystal structure of a putative tRNA (guanine-7-)-methyltransferase (trmD) from Staphylococcus aureus subsp. aureus MRSA252
Authors: Halavaty, A.S., Minasov, G., Winsor, J., Dubrovska, I., Shuvalova, L., See, R., Zoraghi, R., Reiner, N., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90271    community request
Title: Crystal Structure of Swine Flu Virus NS1 Effector Domain from H1N1 Influenza A/California/07/2009.
Authors: D.H. Fremont, Y.Y.L. Yu, C.A. Nelson, Center for Structural Genomics of Infectious Diseases.





Target IDP90271    community request
Title: Crystal Structure of Swine Flu Virus NS1 Deposition Title N-Terminal RNA Binding Domain from H1N1 Influenza A/Californi /07/2009
Authors: Brunzelle, J.S. Wawrzak, Z. Skarina, T. Onopriyenko, O. Savchenko, A. Anderson, W.F. CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES (CSGID)





Target IDP90355    community request
Title: 1.25 ANGSTROM CRYSTAL STRUCTURE OF A PUTATIVE PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN (PEBP) HOMOLOG CT736 FROM CHLAMYDIA TRACHOMATIS D/UW-3/CX
Authors: J.S.BRUNZELLE, Z.WAWRZAK, O.ONOPRIYENKO, A.SAVCHENKO, W.F.ANDERSON, CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES (CSGID)





Target IDP90525    community request
Title: 1.77 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase from Vibrio cholerae O1 biovar eltor str. N16961
Authors: Halavaty, A.S. Shuvalova, L. Minasov, G. Dubrovska, I. Winsor, J. Glass, E.M. Peterson, S.N. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90549    community request
Title: Phosphopantetheine adenylyltransferase from Yersinia pestis complexed with coenzyme A.
Authors: Osipiuk, J., Maltseva, N., Makowska-Grzyska, M., Kwon, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90549    community request
Title: Phosphopantetheine adenylyltransferase from Yersinia pestis.
Authors: Osipiuk, J., Maltseva, N., Makowska-Grzyska, M., Kwon, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90555    community request
Title: Crystal Structure of Tryptophanyl-tRNA Synthetase from Campylobacter jejuni
Authors: Kim, Y., Zhou, M., Hasseman, J., Anderson, W.F., Joachimiak, A., CSGID.





Target IDP90557    community request
Title: Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from Vibrio cholerae O1 biovar eltor str. N16961 in complex with NADP+
Authors: Hou, J., Chruszcz, M., Onopriyenko, O., Grimshaw, S., Porebski, P., Zheng, H., Savchenko, A., Anderson, W.,Minor, W.





Target IDP90564    community request
Title: Crystal structure of transketolase from Campylobacter jejuni subsp. jejuni NCTC 11168
Authors: Nocek B., Makowska-Grzyska M., Maltseva N., Grimshaw S., Anderson,W., Joachimiak, A.





Target IDP90564    community request
Title: Crystal structure of transketolase in complex with thiamin diphosphate and calcium ion
Authors: Nocek, B.,Makowska-Grzyska, M., Maltseva, N., Grimshaw, S., Joachimiak, A, Anderson, W., CSGID, NIAID,





Target IDP90564    community request
Title: Crystal structure of transketolase in complex with thiamine diposphate, ribose-5-phosphate and calcium ion
Authors: Nocek, B., Makowska-Grzyska, M., Maltseva, N., Grimshaw, S., Anderson, W., Joachimiak, A., CSGID





Target IDP90564    community request
Title: Crystal structure of transketolase in complex with thiamine diposphate, ribose-5-phosphate (pyranose form) and magnesium ion
Authors: Nocek, B., Makowska-Grzyska, M., Maltseva, N., Grimshaw, S., Anderson, W., Joachimiak, A., CSGID





Target IDP90574    community request
Title: Crystal structure of acetylornithine aminotransferase (argD) from Campylobacter jejuni
Authors: Anderson, S.M., Wawrzak, Z., Onopriyenko, O., Skarina, T., Anderson, W.F., Savchenko, A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90587    community request
Title: 2.00 Angstrom resolution crystal structure of a catalytic subunit of an aspartate carbamoyltransferase (pyrB) from Yersinia pestis CO92
Authors: Halavaty, A.S. Minasov, G. Dubrovska, I. Winsor, J. Shuvalova, L. Peterson, S. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90591    community request
Title: Crystal structure of tryptophanyl-tRNA synthetase from Yersinia pestis CO92
Authors: Nocek,B., Maltseva, N., Papazisi, L., Joachimiak, A. Anderson, W., CSGID,NIAID





Target IDP90611    community request
Title: 1.8 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with TMP, thymidine-5'-diphosphate and ADP
Authors: Halavaty, A.S. Minasov, G. Dubrovska, I. Winsor, J. Shuvalova, L. Kwon, K. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90611    community request
Title: 2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine
Authors: Halavaty, A.S., Minasov, G., Shuvalova, L., Winsor, J., Dubrovska, I., Peterson, S., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90626    community request
Title: 1.02 Angstrom resolution crystal structure of 3-phosphoshikimate 1- carboxyvinyltransferase from Vibrio cholerae in complex with shikimate-3-phosphate (partially photolyzed) and glyphosate.
Authors: G.Minasov, S.H.Light, A.Halavaty, G.Shuvalova, L.Papazisi, W.F.Anderson, Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90646    community request
Title: Crystal Structure of Probable Cytoplasmic L-asparaginase from Campylobacter jejuni
Authors: Kim, Y., Makowska-Grzyska, M., Maltseva, N., Papazisi, L., Anderson, W.F., Joachimiak, A., CSGID





Target IDP90671    community request
Title: Pyridoxal phosphate biosynthetic protein PdxJ from Campylobacter jejuni.
Authors: Osipiuk, J., Zhou, M., Kwon, K., Anderson, W., Joachimiak, A.





Target IDP90671    community request
Title: Pyridoxal phosphate biosynthetic protein PdxJ from Campylobacter jejuni in complex with pyridoxine-5'-phosphate.
Authors: Osipiuk, J., Zhou, M., Kwon, K., Anderson, W., Joachimiak, A.





Target IDP90682    community request
Title: Crystal structure of serine hydroxymethyltransferase from Campylobacter jejuni
Authors: Anderson, S.M., Wawrzak, Z., Onopriyenko, O., Hasseman, J., Anderson, W.F., Savchenko, A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90711    community request
Title: Crystal Structure of Dihydrodipicolinate Synthase Campylobacter jejuni subsp. jejuni NCTC 11168
Authors: Kim, Y., Zhou, M., Hasseman, J., Anderson, W.F., Joachimiak, A. CSGID





Target IDP90711    community request
Title: Crystal Structure of Dihydrodipicolinate Synthase from Campylobacter jejuni
Authors: Kim, Y., Zhou, M., Kwon, K., Anderson, W.F., Joachimiak, A., CSGID





Target IDP90718    community request
Title: Putative RNA methyltransferase from Yersinia pestis.
Authors: Osipiuk, J., Maltseva, N., Peterson, S., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90718    community request
Title: Putative RNA methyltransferase from Yersinia pestis in complex with S-adenosyl-L-homocysteine.
Authors: Osipiuk, J., Maltseva, N., Peterson, S., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90771    community request
Title: 1.65 Angstrom Resolution Crystal Structure of Type II 3-Dehydroquinate Dehydratase (aroQ) from Yersinia pestis.
Authors: Minasov, G. Light, S.H. Shuvalova, L. Dubrovska, I. Winsor, J. Papazisi, L. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID).





Target IDP90784    community request


Target IDP90784    community request
Title: CRYSTAL STRUCTURE OF LIGAND-FREE BIFUNCTIONAL FOLYLPOLYGLUTAMATE SYNTHASE/DIHYDROFOLATE SYNTHASE FROM YERSINIA PESTIS C092
Authors: B NOCEK,N.MALTSEVA,M.MAKOWSKA-GRZYSKA, L.PAPAZISI,W.ANDERSON,A.JOACHIMIAK,NIAID





Target IDP90785    community request
Title: 2.1 Angstrom resolution crystal structure of an orotate phosphoribosyltransferase (pyrE) from Vibrio cholerae O1 biovar eltor str. N16961
Authors: Halavaty, A.S. Minasov, G. Shuvalova, L. Dubrovska, I. Winsor, J. Kwon, K. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90792    community request
Title: 1.45 Angstrom Resolution Crystal Structure of Shikimate 5-Dehydrogenase (aroE) from Vibrio cholerae.
Authors: G.Minasov, S.H.Light, L.Shuvalova, L.Papazisi, W.F.Anderson, Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90797    community request
Title: Crystal Structure of Pantoate-beta-Alanine Ligase from Salmonella typhimurium
Authors: Kim, Y., Makowska-Grzyska, M., Maltseva, N., Kwon, K., Anderson, W.F., Joachimiak, A., CSGID





Target IDP90800    community request
Title: Crystal Structure of Pantoate-Beta-alanine Ligase from Campylobacter jejuni
Authors: Kim, Y., Zhou, M., Papazisi, L., Anderson, W.F., Joachimiak, A., CSGID





Target IDP90820    community request
Title: D-Erythronate-4-Phosphate Dehydrogenase complexed with NAD
Authors: E.V.Filippova,Z.Wawrzak, O.Onopriyenko, A.Savchenko, A.Edwards, W.F.Anderson, Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90849    community request
Title: Crystal Structure of Phosphoserine Aminotransferase from Campylobacter jejuni
Authors: Kim, Y., Gu, M., Papazisi, L., Anderson, W.F., Joachimiak, A., CSGID





Target IDP90862    community request
Title: 2.2 Angstrom Resolution Crystal Structure of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni.
Authors: G.Minasov, A.Halavaty, L.Shuvalova, I.Dubrovska, J.Winsor, L.Papazisi, W.F.Anderson, Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90862    community request
Title: Structural Flexibility in Region Involved in Dimer Formation of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni.
Authors: Minasov, G., Halavaty, A., Shuvalova, L., Dubrovska, I., Winsor, J., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90886    community request
Title: 1.8 Angstrom Resolution Crystal Structure of Diaminopimelate Decarboxylase (lysA) from Vibrio cholerae.
Authors: Minasov, G., Halavaty, A., Shuvalova, L., Dubrovska, I., Winsor, J., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90895    community request
Title: Crystal Structure of Nicotinate Phosphoribosyltransferasefrom Yersinia pestis
Authors: Maltseva, N., Kim, Y., Gu, M., Anderson, W.F., Joachimiak, A., CSGID





Target IDP90915    community request
Title: Crystal structure of 4-hydroxythreonine-4-phosphate dehydrogenase from Yersinia pestis CO92
Authors: B. Nocek, N. Maltseva, K. Kwon, A. Joachimiak, W. Anderson.





Target IDP90922    community request
Title: 1.85 Angstrom Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2.
Authors: Minasov, G., Light, S.H., Shuvalova, L., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90922    community request
Title: Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 with Citrate Bound to the Active Site.
Authors: Minasov, G. Light, S.H. Shuvalova, L. Papazisi, L. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90922    community request
Title: Crystal Structure of Type I 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 in Covalent Complex with Dehydroquinate.
Authors: Minasov, G. Light, S.H. Shuvalova, L. Papazisi, L. Anderson, W.F. Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90922    community request
Title: Crystal Structure of K170M Mutant of Type I 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2 in Non-Covalent Complex with Dehydroquinate.
Authors: G.Minasov, S.H.Light, L.Shuvalova, L.Papazisi, W.F.Anderson, Center for Structural Genomics of Infectious Diseases (CSGID)





Target IDP90922    community request
Title: 1.03 Angstrom Crystal Structure of Q236A Mutant Type I Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium
Authors: Light, S.H., Minasov, G., Shuvalova, L., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)





This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200700058C.