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Structure of IDP90271

Crystal Structure of Swine Flu Virus NS1 Effector Domain fromH1N1 Influenza A/California/07/2009.

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CSGID target
IDP90271 
PDB Id
3M5R (NCBI MMDB) 
Authors
D.H. Fremont, Y.Y.L. Yu, C.A. Nelson, Center for Structural Genomics of Infectious Diseases. 
Responsible person
Chris Nelson 
Responsible lab
Washington University 
Deposition Date
Mar 13, 2010 
Release Date
Apr 07, 2010 

Annotation

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Description
The nonstructural protein NS1 is employed by influenza virus to evade host immune responses. Several studies have implicated the NS1 protein in conferring increased pathogenicity and virulence on emergent influenza strains. The NS1 virulence factor is believed to participate in multiple host-cell interactions regulating processes as diverse as viral replication, host innate and adaptive immunity, and cellular signaling. The NS1 protein consists of a N-terminal RNA-binding domain and a C-terminal protein-binding "effector" domain. The protein is being studied both for its potential in vaccine development and for its potential in antiviral drug design. 
Functional assignment
 
Slides:
  • Asymmetric unit
  • Biological unit
  • B-factors distribution
  • B-factors distribution on the surface
  • Homolog superposition
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    secondary structure, N to C, molecule

    Ligands

    Ligand code Name Ligand type

    Structure information

    View structure information | Edit structure information (upload a PDB file)

    Unit cell parameters

    Space Group
    P 1 21 1  
    Unit Cell

    a=73.53Å, b=70.80Å, c=96.69Å
    α=90.00, β=110.30, γ=90.00  
    Solvent content
    52.98  
    Matthews coefficient
    2.62  

    Refinement

    Data for the highest resolution shell is in parentheses.
    Resolution range
    50.00-2.01Å (2.08-2.01Å)  
    Rall(%)
    20.8  
    Rwork(%)
    20.7 (25.6)  
    Rfree(%)
    24.4 (31.2)  
    Num. observed reflections
    57329 (4659)  
    Num. Rfree reflections
    1547 (127)  
    Completeness(%)
    91.8 (0.8)  

    Model parameters

    Num Atoms
    5848  
    Num Waters
    288  
    Num Hetatoms
    288  
    Model mean isotropic B factor (Å2)
    40.530  
    RMSD bond length (Å)
    0.008  
    RMSD bond angle
    1.104°  
    RMSD dihedral angle
    14.7°
     
    Filename uploaded
    pdb_extract_coord_13282.cif (uploaded on Mar 16, 2010 4:15 PM)  
    Inserted
    Mar 16, 2010