Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01034 (show subtarget assignments)	0	work_stopped	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02782 (show subtarget assignments)	0	work_stopped	GBAA4874	161611196	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	252	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4F	94.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00783 (show subtarget assignments)	0	work_stopped	SACOL0885	57284344		pathogenicity island protein, integrase ...	406	Conserved Gene / Pathway	Phase 2: March 2008	3NKH	54.2%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP01031 (show subtarget assignments)	0	work_stopped	STM3497	16766785	yrfH	ribosome-associated heat shock protein H...	133	Conserved Gene / Pathway	Phase 2: March 2008	1DM9	95.5%	Salmonella enterica	Protein synthesis	Other

IDP01688 (show subtarget assignments)	0	work_stopped	Cj1313	15792636		GNAT family acetyltransferase [Campyloba...	157	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3EG7	22.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02688 (show subtarget assignments)	0	work_stopped	YPO0921	16121226	pgk	phosphoglycerate kinase [Yersinia pestis...	387	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1ZMR	88.6%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00400 (show subtarget assignments)	0	work_stopped	YPO2222	16122451	ribA	GTP cyclohydrolase II	196	Virulence Associated Factor	Phase 2: March 2008	2BZ0	88.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00769 (show subtarget assignments)	0	work_stopped	SACOL0472	57285499		superantigen-like protein	308	Virulence Associated Factor	Phase 2: March 2008	3URY	60.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00906 (show subtarget assignments)	0	work_stopped	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01029 (show subtarget assignments)	0	work_stopped	STM1916	16765258	cheY	chemotaxis regulator transmitting signal...	129	Conserved Gene / Pathway	Phase 2: March 2008	2FKA	100%	Salmonella enterica	Cellular processes	Other

IDP01151 (show subtarget assignments)	0	work_stopped	BA_5433	30259901		UDP-N-acetylglucosamine 2-epimerase	371	Conserved Gene / Pathway	Phase 2: March 2008	3BEO	99.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01680 (show subtarget assignments)	0	work_stopped	VC0902	161582018	queF	7-cyano-7-deazaguanine reductase [Vibrio...	281	Conserved; Drug target homolg; Drug target functions	Phase 3: June 2008	3BP1	100%	Vibrio cholerae	N/A	N/A

IDP01980 (show subtarget assignments)	0	work_stopped	STM3054	16766355	gcvH	glycine cleavage system protein H [Salmo...	129	Conserved; Drug target functions	Phase 3: June 2008	3A8I	98.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP02612 (show subtarget assignments)	0	work_stopped	GBAA5170	50196964	dapF	diaminopimelate epimerase [Bacillus anth...	288	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OTN	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP00131 (show subtarget assignments)	0	work_stopped	NT01ST2113	16765046	rnb	exoribonuclease II	644	Essential	Phase 1: October 2007	2ID0	90.7%	Salmonella enterica	Transcription	Degradation of RNA

IDP00327 (show subtarget assignments)	0	work_stopped	Cj1634c	15792939	aroC	chorismate synthase	362	Drug Target Function	Phase 2: March 2008	1SQ1	100%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00568 (show subtarget assignments)	0	work_stopped	YPO0106	16120453	hslV	ATP-dependent protease peptidase subunit...	174	Conserved Gene / Pathway	Phase 2: March 2008	1E94	90.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00768 (show subtarget assignments)	0	work_stopped	SACOL0470	57285497		superantigen-like protein	352	Virulence Associated Factor	Phase 2: March 2008	3URY	40.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00871 (show subtarget assignments)	0	work_stopped	STM1444	161353603	slyA	transcriptional regulator SlyA	144	Drug Target Function	Phase 2: March 2008	3Q5F	98.6%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00905 (show subtarget assignments)	0	work_stopped	STM0126	16763516	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	438	Essential Gene	Phase 2: March 2008	1E0D	92.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00945 (show subtarget assignments)	0	work_stopped	STM0977	16764337	serC	phosphoserine aminotransferase	362	Conserved Gene / Pathway	Phase 2: March 2008	3QM2	100%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP01019 (show subtarget assignments)	0	work_stopped	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01077 (show subtarget assignments)	0	work_stopped	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01090 (show subtarget assignments)	0	work_stopped	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP01234 (show subtarget assignments)	0	work_stopped	BA_5509	30259969		UDP-N-acetylglucosamine 2-epimerase	371	Drug Target Function	Phase 2: March 2008	3BEO	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01348 (show subtarget assignments)	0	work_stopped	VCA0219	15600988		haemolysin	741	Conserved Gene / Pathway	Phase 2: March 2008	1XEZ	94.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01751 (show subtarget assignments)	0	work_stopped	Cj1312	15792635		flagellar protein [Campylobacter jejuni ...	274	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3HBM	99.6%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01949 (show subtarget assignments)	0	work_stopped	STM1822	16765163	yoaB	putative translation initiation inhibito...	114	Conserved; Drug target functions	Phase 3: June 2008	3GTZ	99.1%	Salmonella enterica	Unknown function	General

IDP02047 (show subtarget assignments)	0	work_stopped	STM3041c	39546356	prfB	peptide chain release factor 2 [Salmonel...	358	Essential; Drug target functions	Phase 3: June 2008	1GQE	91.9%	Salmonella enterica	N/A	N/A

IDP02589 (show subtarget assignments)	0	work_stopped	AAW36394	57284300	gapA1	glyceraldehyde 3-phosphate dehydrogenase...	336	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), gapC, catalyzes the oxidative ...	Phase 3: June 2008	3K73	100%	Staphylococcus aureus	N/A	N/A

IDP00116 (show subtarget assignments)	0	work_stopped	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00129 (show subtarget assignments)	0	work_stopped	NT01ST3985	16766479	mdaB	NADPH-specific quinone oxidoreductase	193	Virulence	Phase 1: October 2007	2AMJ	91.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00100 (show subtarget assignments)	0	work_stopped	NT01SF2345	30041591	cheW	positive regulator of CheA protein activ...	167		Phase 1: October 2007	2HO9	100%	Shigella flexneri	Cellular processes	Chemotaxis and motility

IDP00326 (show subtarget assignments)	0	work_stopped	Cj1607	15792912	ispDF	bifunctional 2-C-methyl-D-erythritol 4-p...	371	Drug Target Function	Phase 2: March 2008	1W55	100%	Campylobacter jejuni	Amino acid biosynthesis	Histidine family

IDP00567 (show subtarget assignments)	0	work_stopped	YPO1113	16121413	kgd	alpha-ketoglutarate decarboxylase	935	Virulence Associated Factor	Phase 2: March 2008	2JGD	87.8%	Yersinia pestis	Energy metabolism	TCA cycle

IDP00037 (show subtarget assignments)	0	work_stopped	BA_1887	30256548		enterotoxin	386	Virulence	Phase 1: October 2007			Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00658 (show subtarget assignments)	0	work_stopped	SACOL0801	57285762	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	307	Drug Target Function	Phase 2: March 2008	1HSK	99.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00754 (show subtarget assignments)	0	work_stopped	SACOL0095	57286644	spa	immunoglobulin G binding protein A precu...	508	Conserved Gene / Pathway	Phase 2: March 2008	1BDC	11.6%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP00826 (show subtarget assignments)	0	work_stopped	SACOL2422	57285152	hlgB	gamma hemolysin, component B	325	Conserved Gene / Pathway	Phase 2: March 2008	1LKF	92%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00857 (show subtarget assignments)	0	work_stopped	STM1177	16764533	flgE	flagellar hook protein FlgE	403	Conserved Gene / Pathway	Phase 2: March 2008	3A69	99.8%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00892 (show subtarget assignments)	0	work_stopped	STM3881	16767165	rbsD	high-affinity D-ribose transport protein...	139	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00904 (show subtarget assignments)	0	work_stopped	STM0124	16763514	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	87.6%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00913 (show subtarget assignments)	0	work_stopped	STM0219	16763609	frr	ribosome recycling factor	185	Conserved Gene / Pathway	Phase 2: March 2008	1EK8	94.1%	Salmonella enterica	Protein synthesis	Translation factors

IDP00934 (show subtarget assignments)	0	work_stopped	STM0779	16764143	modE	DNA-binding transcriptional dual regulat...	262	Conserved Gene / Pathway	Phase 2: March 2008	1B9M	89.3%	Salmonella enterica	Transport and binding proteins	Anions

IDP00990 (show subtarget assignments)	0	work_stopped	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01015 (show subtarget assignments)	0	work_stopped	STM2791	16766102	gabD	succinate-semialdehyde dehydrogenase I	482	Conserved Gene / Pathway	Phase 2: March 2008	3JZ4	90%	Salmonella enterica	Central intermediary metabolism	Other

IDP01057 (show subtarget assignments)	0	work_stopped	STM3445	16766734	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01068 (show subtarget assignments)	0	work_stopped	STM3920	16767195	wecB	UDP-N-acetyl glucosamine-2-epimerase	376	Drug Target Function	Phase 2: March 2008	1F6D	85.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01079 (show subtarget assignments)	0	work_stopped	STM4167	16767421	hemE	uroporphyrinogen decarboxylase	354	Essential Gene	Phase 2: March 2008	3CYV	96%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01080 (show subtarget assignments)	0	work_stopped	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01197 (show subtarget assignments)	0	work_stopped	BA_1389	81715334		D-alanine--poly(phosphoribitol) ligase s...	503	Conserved Gene / Pathway	Phase 2: March 2008	3DHV	99.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01226 (show subtarget assignments)	0	work_stopped	BA_4187	39931064		Peptide deformylase 2 (PDF 2) (Polypepti...	184	Drug Target Function	Phase 2: March 2008	2OKL	96.2%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP01256 (show subtarget assignments)	0	work_stopped	BA_1232	30255181	fabI	enoyl-(acyl-carrier-protein) reductase	256	Drug Target Function	Phase 2: March 2008	2QIO	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00055 (show subtarget assignments)	0	work_stopped	BA_3696	30258217		blasticidin S deaminase, putative	142	Virulence	Phase 1: October 2007	3B8F	99.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00007 (show subtarget assignments)	0	work_stopped	BA_0847	30254435	racE-1	glutamate racemase	276	Drug Target Homolog	Phase 1: October 2007	2DWU	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01725 (show subtarget assignments)	0	work_stopped	GBAA2534	47527824		acetyltransferase [Bacillus anthracis st...	168	CONSERVED	Phase 3: June 2008	3FBU	100%	Bacillus anthracis	N/A	N/A

IDP01789 (show subtarget assignments)	0	work_stopped	Cj1613c	15792918		hypothetical protein Cj1613c [Campylobac...	251	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3SWJ	98.8%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01937 (show subtarget assignments)	0	work_stopped	Cj0727	15792076		putative periplasmic solute-binding prot...	348	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1Y4T	19.5%	Campylobacter jejuni	Cell envelope	Other

IDP01983 (show subtarget assignments)	0	work_stopped	Cj1437c	15792755		putative aminotransferase [Campylobacter...	367	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3GET	28.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01990 (show subtarget assignments)	0	work_stopped	Cj1435c	15792753		hypothetical protein Cj1435c [Campylobac...	211	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3FVV	26.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02537 (show subtarget assignments)	0	work_stopped	GBAA4558	47778307	nadD	nicotinic acid mononucleotide adenylyltr...	171	Conserved; Drug target functions	Phase 3: June 2008	2QTM	99.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02547 (show subtarget assignments)	0	work_stopped	Cj1316c	15792639		flagellin modification protein, PseA [Ca...	378	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00106 (show subtarget assignments)	0	work_stopped	NT01SF3707	30042635	mdaB	modulator of drug activity B	193	Virulence	Phase 1: October 2007	2AMJ	97.9%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP00113 (show subtarget assignments)	0	work_stopped	NT01SAA0015	16119212	blaI	PENICILLINASE REPRESSOR	126	Virulence	Phase 1: October 2007	1SD4	100%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00124 (show subtarget assignments)	0	work_stopped	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00125 (show subtarget assignments)	0	work_stopped	NT01ST1183	16764320	lrp	leucine-responsive transcriptional regul...	164		Phase 1: October 2007	2GQQ	98.8%	Salmonella enterica	Central intermediary metabolism	Other

IDP00068 (show subtarget assignments)	0	work_stopped	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00163 (show subtarget assignments)	0	work_stopped	VC0838	15640855	tcpN/toxT	TCP pilus virulence regulatory protein	276	Virulence	Phase 1: October 2007	3GBG	100%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00070 (show subtarget assignments)	0	work_stopped	NT01ST1465	16419700	flgK	hook-filament junction protein 1	553	Virulence	Phase 1: October 2007	2D4Y	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00071 (show subtarget assignments)	0	work_stopped	NT01ST2260	16420352	yeaZ	putative molecular chaperone	231	Essential	Phase 1: October 2007	2GEL	100%	Salmonella enterica	Unknown function	General

IDP00018 (show subtarget assignments)	0	work_stopped	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00561 (show subtarget assignments)	0	work_stopped	YPO1046	16121346	pyrH	uridylate kinase	241	Conserved Gene / Pathway	Phase 2: March 2008	2BNE	90.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00074 (show subtarget assignments)	0	work_stopped	NT01ST3685	16421504	pyrG	CTP synthetase	545	Essential	Phase 1: October 2007	1S1M	95%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00075 (show subtarget assignments)	0	work_stopped	NTL01ST3174	16421824	yraO	putative phosphoheptose isomerase	196		Phase 1: October 2007	2YVA	98%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00594 (show subtarget assignments)	0	work_stopped	YPO3569	16123713	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	420	Conserved Gene / Pathway	Phase 2: March 2008	1NAW	91.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00077 (show subtarget assignments)	0	work_stopped	NTL01ST3489	16422154	yhiQ	putative SAM-dependent methyltransferase...	252		Phase 1: October 2007	2PKW	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00078 (show subtarget assignments)	0	work_stopped	NTL01ST3606	16422278	rfaF	ADP-heptose; LPS heptosyltransferase 1	348		Phase 1: October 2007	1PSW	91.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00747 (show subtarget assignments)	0	work_stopped	SACOL1768	57286203		GAF domain protein	154	Drug Target Function	Phase 2: March 2008	3KSF	98.7%	Staphylococcus aureus	Unknown function	General

IDP00787 (show subtarget assignments)	0	work_stopped	SACOL1016	57284388	fabI	enoyl-(acyl carrier protein) reductase	256	Drug Target Function	Phase 2: March 2008	3GNS	100%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00796 (show subtarget assignments)	0	work_stopped	SACOL1244	57285984	fabD	malonyl CoA-acyl carrier protein transac...	308	Drug Target Function	Phase 2: March 2008	3IM9	98.7%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00082 (show subtarget assignments)	0	work_stopped	NTL01ST4427	16423142	lplA	lipoate-protein ligase A	338		Phase 1: October 2007	1X2G	93.2%	Salmonella enterica	Cell envelope	Other

IDP00831 (show subtarget assignments)	0	work_stopped	SACOL2545	57285227	sdaAB	L-serine dehydratase, iron-sulfur-depend...	226	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP00880 (show subtarget assignments)	0	work_stopped	STM0534	16763914	purE	phosphoribosylaminoimidazole carboxylase...	169	Conserved Gene / Pathway	Phase 2: March 2008	1QCZ	95.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00891 (show subtarget assignments)	0	work_stopped	STM3816	16767101	ccmD	heme exporter protein C	70	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Energy metabolism	Electron transport

IDP00900 (show subtarget assignments)	0	work_stopped	STM4247	16767497	alr	alanine racemase	359	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	91.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00903 (show subtarget assignments)	0	work_stopped	STM0123	16763513	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	495	Essential Gene	Phase 2: March 2008	1E8C	91.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00909 (show subtarget assignments)	0	work_stopped	STM0171	16763561	yadF	carbonic anhydrase	220	Conserved Gene / Pathway	Phase 2: March 2008	3QY1	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP00089 (show subtarget assignments)	0	work_stopped	NT01ST0526	16418927	dxs	1-deoxyxylulose-5-phosphate synthase; fl...	620	Essential	Phase 1: October 2007	2O1S	96.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00916 (show subtarget assignments)	0	work_stopped	STM0247	16763636	metN	DL-methionine transporter ATP-binding su...	343	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	95.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00091 (show subtarget assignments)	0	work_stopped	NTL01SF0342	30040153	ribD	bifunctional pyrimidine deaminase/reduct...	367	Essential	Phase 1: October 2007	2G6V	97.8%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00957 (show subtarget assignments)	0	work_stopped	STM1202	16764557	ycfH	predicted metallodependent hydrolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1YIX	92.8%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP00964 (show subtarget assignments)	0	work_stopped	STM1439	16764787	ydhF	putative aldo/keto reductase	298	Conserved Gene / Pathway	Phase 2: March 2008	1OG6	88.9%	Salmonella enterica	Unknown function	General

IDP00094 (show subtarget assignments)	0	work_stopped	NT01SF0993	30040622	lrp	regulator for leucine (or lrp) regulon a...	164		Phase 1: October 2007	2GQQ	99.4%	Shigella flexneri	Central intermediary metabolism	Other

IDP00993 (show subtarget assignments)	0	work_stopped	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01035 (show subtarget assignments)	0	work_stopped	STM4146	16767400	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01037 (show subtarget assignments)	0	work_stopped	STM2927	16766233	surE	stationary phase survival protein SurE	253	potential drug target / Conserved Gene / Pathway	Phase 2: March 2008	2V4N	100%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP00049 (show subtarget assignments)	0	work_stopped	BA_3355	30257898		thiol-activated cytolysin	512	Virulence	Phase 1: October 2007	3CQF	93.6%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00099 (show subtarget assignments)	0	work_stopped	NT02SF1983	30041448	ynhD	putative ATP-binding component of a tran...	248	Conserved; CD; Drug target functions	Phase 1: October 2007	2D3W	99.6%	Shigella flexneri	Transport and binding proteins	Unknown substrate

IDP90227 (show subtarget assignments)	0	work_stopped	BAS1428	49184445	-	Histidinol-phosphate aminotransferase (E...	370	Histidinol phosphate aminotransferase (EC 2.6.1.9) is a key enzyme on the histid...	January 2009	3FFH	46.2%	Bacillus anthracis

IDP90185 (show subtarget assignments)	0	work_stopped	AAM13488.1	20153027	CPXV041 CDS	CPXV041 protein	284	K1L like Host range protein	Community Requests	3KEA	95.1%	Cowpox virus	host defense modulator	0

IDP01034
(show subtarget assignments)

0

work_stopped

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02782
(show subtarget assignments)

0

work_stopped

GBAA4874

161611196

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

252

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4F

94.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00783
(show subtarget assignments)

0

work_stopped

SACOL0885

57284344

pathogenicity island protein, integrase ...

406

Conserved Gene / Pathway

Phase 2: March 2008

3NKH

54.2%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP01031
(show subtarget assignments)

0

work_stopped

STM3497

16766785

yrfH

ribosome-associated heat shock protein H...

133

Conserved Gene / Pathway

Phase 2: March 2008

1DM9

95.5%

Salmonella enterica

Protein synthesis

Other

IDP01688
(show subtarget assignments)

0

work_stopped

Cj1313

15792636

GNAT family acetyltransferase [Campyloba...

157

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3EG7

22.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02688
(show subtarget assignments)

0

work_stopped

YPO0921

16121226

pgk

phosphoglycerate kinase [Yersinia pestis...

387

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1ZMR

88.6%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00400
(show subtarget assignments)

0

work_stopped

YPO2222

16122451

ribA

GTP cyclohydrolase II

196

Virulence Associated Factor

Phase 2: March 2008

2BZ0

88.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00769
(show subtarget assignments)

0

work_stopped

SACOL0472

57285499

superantigen-like protein

308

Virulence Associated Factor

Phase 2: March 2008

3URY

60.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00906
(show subtarget assignments)

0

work_stopped

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01029
(show subtarget assignments)

0

work_stopped

STM1916

16765258

cheY

chemotaxis regulator transmitting signal...

129

Conserved Gene / Pathway

Phase 2: March 2008

2FKA

100%

Salmonella enterica

Cellular processes

Other

IDP01151
(show subtarget assignments)

0

work_stopped

BA_5433

30259901

UDP-N-acetylglucosamine 2-epimerase

371

Conserved Gene / Pathway

Phase 2: March 2008

3BEO

99.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01680
(show subtarget assignments)

0

work_stopped

VC0902

161582018

queF

7-cyano-7-deazaguanine reductase [Vibrio...

281

Conserved; Drug target homolg; Drug target functions

Phase 3: June 2008

3BP1

100%

Vibrio cholerae

N/A

IDP01980
(show subtarget assignments)

0

work_stopped

STM3054

16766355

gcvH

glycine cleavage system protein H [Salmo...

129

Conserved; Drug target functions

Phase 3: June 2008

3A8I

98.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP02612
(show subtarget assignments)

0

work_stopped

GBAA5170

50196964

dapF

diaminopimelate epimerase [Bacillus anth...

288

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OTN

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP00131
(show subtarget assignments)

0

work_stopped

NT01ST2113

16765046

rnb

exoribonuclease II

644

Essential

Phase 1: October 2007

2ID0

90.7%

Salmonella enterica

Transcription

Degradation of RNA

IDP00327
(show subtarget assignments)

0

work_stopped

Cj1634c

15792939

aroC

chorismate synthase

362

Drug Target Function

Phase 2: March 2008

1SQ1

100%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00568
(show subtarget assignments)

0

work_stopped

YPO0106

16120453

hslV

ATP-dependent protease peptidase subunit...

174

Conserved Gene / Pathway

Phase 2: March 2008

1E94

90.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00768
(show subtarget assignments)

0

work_stopped

SACOL0470

57285497

superantigen-like protein

352

Virulence Associated Factor

Phase 2: March 2008

3URY

40.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00871
(show subtarget assignments)

0

work_stopped

STM1444

161353603

slyA

transcriptional regulator SlyA

144

Drug Target Function

Phase 2: March 2008

3Q5F

98.6%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00905
(show subtarget assignments)

0

work_stopped

STM0126

16763516

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

438

Essential Gene

Phase 2: March 2008

1E0D

92.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00945
(show subtarget assignments)

0

work_stopped

STM0977

16764337

serC

phosphoserine aminotransferase

362

Conserved Gene / Pathway

Phase 2: March 2008

3QM2

100%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP01019
(show subtarget assignments)

0

work_stopped

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01077
(show subtarget assignments)

0

work_stopped

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01090
(show subtarget assignments)

0

work_stopped

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP01234
(show subtarget assignments)

0

work_stopped

BA_5509

30259969

UDP-N-acetylglucosamine 2-epimerase

371

Drug Target Function

Phase 2: March 2008

3BEO

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01348
(show subtarget assignments)

0

work_stopped

VCA0219

15600988

haemolysin

741

Conserved Gene / Pathway

Phase 2: March 2008

1XEZ

94.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01751
(show subtarget assignments)

0

work_stopped

Cj1312

15792635

flagellar protein [Campylobacter jejuni ...

274

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3HBM

99.6%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01949
(show subtarget assignments)

0

work_stopped

STM1822

16765163

yoaB

putative translation initiation inhibito...

114

Conserved; Drug target functions

Phase 3: June 2008

3GTZ

99.1%

Salmonella enterica

Unknown function

General

IDP02047
(show subtarget assignments)

0

work_stopped

STM3041c

39546356

prfB

peptide chain release factor 2 [Salmonel...

358

Essential; Drug target functions

Phase 3: June 2008

1GQE

91.9%

Salmonella enterica

N/A

IDP02589
(show subtarget assignments)

0

work_stopped

AAW36394

57284300

gapA1

glyceraldehyde 3-phosphate dehydrogenase...

336

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), gapC, catalyzes the oxidative ...

Phase 3: June 2008

3K73

100%

Staphylococcus aureus

N/A

IDP00116
(show subtarget assignments)

0

work_stopped

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00129
(show subtarget assignments)

0

work_stopped

NT01ST3985

16766479

mdaB

NADPH-specific quinone oxidoreductase

193

Virulence

Phase 1: October 2007

2AMJ

91.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00100
(show subtarget assignments)

0

work_stopped

NT01SF2345

30041591

cheW

positive regulator of CheA protein activ...

167

Phase 1: October 2007

2HO9

100%

Shigella flexneri

Cellular processes

Chemotaxis and motility

IDP00326
(show subtarget assignments)

0

work_stopped

Cj1607

15792912

ispDF

bifunctional 2-C-methyl-D-erythritol 4-p...

371

Drug Target Function

Phase 2: March 2008

1W55

100%

Campylobacter jejuni

Amino acid biosynthesis

Histidine family

IDP00567
(show subtarget assignments)

0

work_stopped

YPO1113

16121413

kgd

alpha-ketoglutarate decarboxylase

935

Virulence Associated Factor

Phase 2: March 2008

2JGD

87.8%

Yersinia pestis

Energy metabolism

TCA cycle

IDP00037
(show subtarget assignments)

0

work_stopped

BA_1887

30256548

enterotoxin

386

Virulence

Phase 1: October 2007

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00658
(show subtarget assignments)

0

work_stopped

SACOL0801

57285762

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

307

Drug Target Function

Phase 2: March 2008

1HSK

99.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00754
(show subtarget assignments)

0

work_stopped

SACOL0095

57286644

spa

immunoglobulin G binding protein A precu...

508

Conserved Gene / Pathway

Phase 2: March 2008

1BDC

11.6%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP00826
(show subtarget assignments)

0

work_stopped

SACOL2422

57285152

hlgB

gamma hemolysin, component B

325

Conserved Gene / Pathway

Phase 2: March 2008

1LKF

92%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00857
(show subtarget assignments)

0

work_stopped

STM1177

16764533

flgE

flagellar hook protein FlgE

403

Conserved Gene / Pathway

Phase 2: March 2008

3A69

99.8%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00892
(show subtarget assignments)

0

work_stopped

STM3881

16767165

rbsD

high-affinity D-ribose transport protein...

139

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00904
(show subtarget assignments)

0

work_stopped

STM0124

16763514

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

87.6%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00913
(show subtarget assignments)

0

work_stopped

STM0219

16763609

frr

ribosome recycling factor

185

Conserved Gene / Pathway

Phase 2: March 2008

1EK8

94.1%

Salmonella enterica

Protein synthesis

Translation factors

IDP00934
(show subtarget assignments)

0

work_stopped

STM0779

16764143

modE

DNA-binding transcriptional dual regulat...

262

Conserved Gene / Pathway

Phase 2: March 2008

1B9M

89.3%

Salmonella enterica

Transport and binding proteins

Anions

IDP00990
(show subtarget assignments)

0

work_stopped

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01015
(show subtarget assignments)

0

work_stopped

STM2791

16766102

gabD

succinate-semialdehyde dehydrogenase I

482

Conserved Gene / Pathway

Phase 2: March 2008

3JZ4

90%

Salmonella enterica

Central intermediary metabolism

Other

IDP01057
(show subtarget assignments)

0

work_stopped

STM3445

16766734

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01068
(show subtarget assignments)

0

work_stopped

STM3920

16767195

wecB

UDP-N-acetyl glucosamine-2-epimerase

376

Drug Target Function

Phase 2: March 2008

1F6D

85.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01079
(show subtarget assignments)

0

work_stopped

STM4167

16767421

hemE

uroporphyrinogen decarboxylase

354

Essential Gene

Phase 2: March 2008

3CYV

96%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01080
(show subtarget assignments)

0

work_stopped

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01197
(show subtarget assignments)

0

work_stopped

BA_1389

81715334

D-alanine--poly(phosphoribitol) ligase s...

503

Conserved Gene / Pathway

Phase 2: March 2008

3DHV

99.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01226
(show subtarget assignments)

0

work_stopped

BA_4187

39931064

Peptide deformylase 2 (PDF 2) (Polypepti...

184

Drug Target Function

Phase 2: March 2008

2OKL

96.2%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP01256
(show subtarget assignments)

0

work_stopped

BA_1232

30255181

fabI

enoyl-(acyl-carrier-protein) reductase

256

Drug Target Function

Phase 2: March 2008

2QIO

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00055
(show subtarget assignments)

0

work_stopped

BA_3696

30258217

blasticidin S deaminase, putative

142

Virulence

Phase 1: October 2007

3B8F

99.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00007
(show subtarget assignments)

0

work_stopped

BA_0847

30254435

racE-1

glutamate racemase

276

Drug Target Homolog

Phase 1: October 2007

2DWU

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01725
(show subtarget assignments)

0

work_stopped

GBAA2534

47527824

acetyltransferase [Bacillus anthracis st...

168

CONSERVED

Phase 3: June 2008

3FBU

100%

Bacillus anthracis

N/A

IDP01789
(show subtarget assignments)

0

work_stopped

Cj1613c

15792918

hypothetical protein Cj1613c [Campylobac...

251

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3SWJ

98.8%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01937
(show subtarget assignments)

0

work_stopped

Cj0727

15792076

putative periplasmic solute-binding prot...

348

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1Y4T

19.5%

Campylobacter jejuni

Cell envelope

Other

IDP01983
(show subtarget assignments)

0

work_stopped

Cj1437c

15792755

putative aminotransferase [Campylobacter...

367

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3GET

28.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01990
(show subtarget assignments)

0

work_stopped

Cj1435c

15792753

hypothetical protein Cj1435c [Campylobac...

211

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3FVV

26.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02537
(show subtarget assignments)

0

work_stopped

GBAA4558

47778307

nadD

nicotinic acid mononucleotide adenylyltr...

171

Conserved; Drug target functions

Phase 3: June 2008

2QTM

99.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02547
(show subtarget assignments)

0

work_stopped

Cj1316c

15792639

flagellin modification protein, PseA [Ca...

378

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00106
(show subtarget assignments)

0

work_stopped

NT01SF3707

30042635

mdaB

modulator of drug activity B

193

Virulence

Phase 1: October 2007

2AMJ

97.9%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP00113
(show subtarget assignments)

0

work_stopped

NT01SAA0015

16119212

blaI

PENICILLINASE REPRESSOR

126

Virulence

Phase 1: October 2007

1SD4

100%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00124
(show subtarget assignments)

0

work_stopped

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00125
(show subtarget assignments)

0

work_stopped

NT01ST1183

16764320

lrp

leucine-responsive transcriptional regul...

164

Phase 1: October 2007

2GQQ

98.8%

Salmonella enterica

Central intermediary metabolism

Other

IDP00068
(show subtarget assignments)

0

work_stopped

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00163
(show subtarget assignments)

0

work_stopped

VC0838

15640855

tcpN/toxT

TCP pilus virulence regulatory protein

276

Virulence

Phase 1: October 2007

3GBG

100%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00070
(show subtarget assignments)

0

work_stopped

NT01ST1465

16419700

flgK

hook-filament junction protein 1

553

Virulence

Phase 1: October 2007

2D4Y

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00071
(show subtarget assignments)

0

work_stopped

NT01ST2260

16420352

yeaZ

putative molecular chaperone

231

Essential

Phase 1: October 2007

2GEL

100%

Salmonella enterica

Unknown function

General

IDP00018
(show subtarget assignments)

0

work_stopped

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00561
(show subtarget assignments)

0

work_stopped

YPO1046

16121346

pyrH

uridylate kinase

241

Conserved Gene / Pathway

Phase 2: March 2008

2BNE

90.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00074
(show subtarget assignments)

0

work_stopped

NT01ST3685

16421504

pyrG

CTP synthetase

545

Essential

Phase 1: October 2007

1S1M

95%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00075
(show subtarget assignments)

0

work_stopped

NTL01ST3174

16421824

yraO

putative phosphoheptose isomerase

196

Phase 1: October 2007

2YVA

98%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00594
(show subtarget assignments)

0

work_stopped

YPO3569

16123713

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

420

Conserved Gene / Pathway

Phase 2: March 2008

1NAW

91.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00077
(show subtarget assignments)

0

work_stopped

NTL01ST3489

16422154

yhiQ

putative SAM-dependent methyltransferase...

252

Phase 1: October 2007

2PKW

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00078
(show subtarget assignments)

0

work_stopped

NTL01ST3606

16422278

rfaF

ADP-heptose; LPS heptosyltransferase 1

348

Phase 1: October 2007

1PSW

91.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00747
(show subtarget assignments)

0

work_stopped

SACOL1768

57286203

GAF domain protein

154

Drug Target Function

Phase 2: March 2008

3KSF

98.7%

Staphylococcus aureus

Unknown function

General

IDP00787
(show subtarget assignments)

0

work_stopped

SACOL1016

57284388

fabI

enoyl-(acyl carrier protein) reductase

256

Drug Target Function

Phase 2: March 2008

3GNS

100%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00796
(show subtarget assignments)

0

work_stopped

SACOL1244

57285984

fabD

malonyl CoA-acyl carrier protein transac...

308

Drug Target Function

Phase 2: March 2008

3IM9

98.7%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00082
(show subtarget assignments)

0

work_stopped

NTL01ST4427

16423142

lplA

lipoate-protein ligase A

338

Phase 1: October 2007

1X2G

93.2%

Salmonella enterica

Cell envelope

Other

IDP00831
(show subtarget assignments)

0

work_stopped

SACOL2545

57285227

sdaAB

L-serine dehydratase, iron-sulfur-depend...

226

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP00880
(show subtarget assignments)

0

work_stopped

STM0534

16763914

purE

phosphoribosylaminoimidazole carboxylase...

169

Conserved Gene / Pathway

Phase 2: March 2008

1QCZ

95.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00891
(show subtarget assignments)

0

work_stopped

STM3816

16767101

ccmD

heme exporter protein C

70

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Energy metabolism

Electron transport

IDP00900
(show subtarget assignments)

0

work_stopped

STM4247

16767497

alr

alanine racemase

359

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

91.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00903
(show subtarget assignments)

0

work_stopped

STM0123

16763513

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

495

Essential Gene

Phase 2: March 2008

1E8C

91.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00909
(show subtarget assignments)

0

work_stopped

STM0171

16763561

yadF

carbonic anhydrase

220

Conserved Gene / Pathway

Phase 2: March 2008

3QY1

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP00089
(show subtarget assignments)

0

work_stopped

NT01ST0526

16418927

dxs

1-deoxyxylulose-5-phosphate synthase; fl...

620

Essential

Phase 1: October 2007

2O1S

96.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00916
(show subtarget assignments)

0

work_stopped

STM0247

16763636

metN

DL-methionine transporter ATP-binding su...

343

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

95.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00091
(show subtarget assignments)

0

work_stopped

NTL01SF0342

30040153

ribD

bifunctional pyrimidine deaminase/reduct...

367

Essential

Phase 1: October 2007

2G6V

97.8%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00957
(show subtarget assignments)

0

work_stopped

STM1202

16764557

ycfH

predicted metallodependent hydrolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1YIX

92.8%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP00964
(show subtarget assignments)

0

work_stopped

STM1439

16764787

ydhF

putative aldo/keto reductase

298

Conserved Gene / Pathway

Phase 2: March 2008

1OG6

88.9%

Salmonella enterica

Unknown function

General

IDP00094
(show subtarget assignments)

0

work_stopped

NT01SF0993

30040622

lrp

regulator for leucine (or lrp) regulon a...

164

Phase 1: October 2007

2GQQ

99.4%

Shigella flexneri

Central intermediary metabolism

Other

IDP00993
(show subtarget assignments)

0

work_stopped

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01035
(show subtarget assignments)

0

work_stopped

STM4146

16767400

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01037
(show subtarget assignments)

0

work_stopped

STM2927

16766233

surE

stationary phase survival protein SurE

253

potential drug target / Conserved Gene / Pathway

Phase 2: March 2008

2V4N

100%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP00049
(show subtarget assignments)

0

work_stopped

BA_3355

30257898

thiol-activated cytolysin

512

Virulence

Phase 1: October 2007

3CQF

93.6%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00099
(show subtarget assignments)

0

work_stopped

NT02SF1983

30041448

ynhD

putative ATP-binding component of a tran...

248

Conserved; CD; Drug target functions

Phase 1: October 2007

2D3W

99.6%

Shigella flexneri

Transport and binding proteins

Unknown substrate

IDP90227
(show subtarget assignments)

0

work_stopped

BAS1428

49184445

-

Histidinol-phosphate aminotransferase (E...

370

Histidinol phosphate aminotransferase (EC 2.6.1.9) is a key enzyme on the histid...

January 2009

3FFH

46.2%

Bacillus anthracis

IDP90185
(show subtarget assignments)

0

work_stopped

AAM13488.1

20153027

CPXV041 CDS

CPXV041 protein

284

K1L like Host range protein

Community Requests

3KEA

95.1%

Cowpox virus

host defense modulator

0

Targets