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Targets
Filter Targets:
Selection Phase:
No Filter
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM 10
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
Clostridium difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
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cloned
crystallized
crystal_structure
diffraction
expressed
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
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CSGID ID
Priority
stage
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00001
(
show subtarget assignments
)
1
cloned
BA_4599
30259099
aldehyde-alcohol dehydrogenase
867
Drug Target Homolog
Phase 1: October 2007
3MY7
24.5%
Bacillus anthracis
Energy metabolism
Fermentation
IDP00005
(
show subtarget assignments
)
1
cloned
BA_0552
30254078
internalin, putative
1070
Virulence/Drug Target Homolog
Phase 1: October 2007
1M9S
13.5%
Bacillus anthracis
Cellular processes
Pathogenesis
IDP00019
(
show subtarget assignments
)
1
cloned
BA_4843
30259344
pykA-2
pyruvate kinase
585
Drug Target Homolog
Phase 1: October 2007
2E28
69.6%
Bacillus anthracis
Energy metabolism
Glycolysis/gluconeogenesis
IDP00022
(
show subtarget assignments
)
1
cloned
BA_5578
81714842
UDP-N-acetylglucosamine 1-carboxyvinyltr...
429
Drug Target Homolog
Phase 1: October 2007
3SG1
49.7%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00023
(
show subtarget assignments
)
1
cloned
BA_5594
30260051
papR
PapR
48
Drug Target Homolog
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Pathogenesis
IDP00033
(
show subtarget assignments
)
1
cloned
BA_1295
30255240
immune inhibitor A metalloprotease
795
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00048
(
show subtarget assignments
)
1
cloned
BA_3330
30257875
beta-lactam antibiotic acylase family pr...
796
Virulence
Phase 1: October 2007
1KEH
22.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00050
(
show subtarget assignments
)
1
cloned
BA_3443
30257983
enhancin family protein
742
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Pathogenesis
IDP00064
(
show subtarget assignments
)
1
cloned
BA_5200
30259683
transcriptional activator tipA, putative...
243
Virulence
Phase 1: October 2007
3QAO
56.2%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP00142
(
show subtarget assignments
)
1
cloned
VC1456
15641467
ctxB
cholera enterotoxin, B subunit
124
Virulence
Phase 1: October 2007
1EEI
81.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00165
(
show subtarget assignments
)
1
cloned
VC0844
15640861
acfA
accessory colonization factor AcfA
215
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00168
(
show subtarget assignments
)
1
cloned
VC2209
15642774
vibF
nonribosomal peptide synthetase VibF, au...
2413
Virulence
Phase 1: October 2007
2VSQ
10.2%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP00171
(
show subtarget assignments
)
1
cloned
YPO0452
16120781
-
putative soluble lytic murein transglyco...
639
Similar to Essential SALTY
Phase 1: October 2007
1QSA
61.8%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00173
(
show subtarget assignments
)
1
cloned
YPO2922
16123109
-
putative membrane protein
486
Virulence
Phase 1: October 2007
3K4U
14.4%
Yersinia pestis
Unknown function
General
IDP00174
(
show subtarget assignments
)
1
cloned
YPO1140
16121437
-
putative membrane protein
272
Similar to Essential SALTY
Phase 1: October 2007
Yersinia pestis
Unknown function
General
IDP00176
(
show subtarget assignments
)
1
cloned
YPO4024
16124147
-
putative iron transport permease
335
Virulence
Phase 1: October 2007
2QI9
23.9%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00179
(
show subtarget assignments
)
1
cloned
YPO0277
16120616
-
putative transmembrane transport protein...
428
Similar to Essential SALTY
Phase 1: October 2007
Yersinia pestis
Unknown function
General
IDP00183
(
show subtarget assignments
)
1
cloned
YPO0613
16120939
-
putative permease protein
293
Virulence
Phase 1: October 2007
2R6G
22.5%
Yersinia pestis
IDP00184
(
show subtarget assignments
)
1
cloned
YPO0624
16120950
-
putative membrane protein
483
Virulence
Phase 1: October 2007
Yersinia pestis
Hypothetical proteins
Conserved
IDP00185
(
show subtarget assignments
)
1
cloned
YPO0639
16120963
-
hypothetical protein
460
Virulence
Phase 1: October 2007
Yersinia pestis
Hypothetical proteins
Conserved
IDP00191
(
show subtarget assignments
)
1
cloned
YPO0932
16121236
-
conserved hypothetical protein
170
Virulence
Phase 1: October 2007
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP00192
(
show subtarget assignments
)
1
cloned
YPO0947
16121251
-
putative virulence determinant
3110
Virulence
Phase 1: October 2007
1AF0
2.9%
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP00194
(
show subtarget assignments
)
1
cloned
YPO0983
16121287
-
putative membrane protein
216
Virulence
Phase 1: October 2007
Yersinia pestis
Hypothetical proteins
Conserved
IDP00195
(
show subtarget assignments
)
1
cloned
YPO1009
16121311
-
probable peptidase
410
Similar to Essential SALTY
Phase 1: October 2007
1VIX
38%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00196
(
show subtarget assignments
)
1
cloned
YPO1051
16121351
-
putative membrane protein
451
Virulence
Phase 1: October 2007
2ZPL
13.5%
Yersinia pestis
IDP00198
(
show subtarget assignments
)
1
cloned
YPO1367
16121647
-
conserved hypothetical protein
106
Similar to Essential SALTY
Phase 1: October 2007
1MBU
84.9%
Yersinia pestis
IDP00205
(
show subtarget assignments
)
1
cloned
YPO1705
16121965
-
tail-specific protease precursor
690
Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...
Phase 1: October 2007
1FC6
15.8%
Yersinia pestis
IDP00215
(
show subtarget assignments
)
1
cloned
YPO2295
16122519
-
haloacid dehalogenase-like hydrolase fam...
224
Virulence
Phase 1: October 2007
3ED5
31.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00217
(
show subtarget assignments
)
1
cloned
YPO2319
16122543
-
putative pepetidase
278
Virulence
Phase 1: October 2007
1AGJ
24.1%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP00222
(
show subtarget assignments
)
1
cloned
YPO3049
16123226
-
putative binding protein-dependent trans...
589
Virulence
Phase 1: October 2007
3DKN
15.3%
Yersinia pestis
IDP00224
(
show subtarget assignments
)
1
cloned
YPO3058
16123235
-
putative membrane protein
288
Virulence
Phase 1: October 2007
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP00225
(
show subtarget assignments
)
1
cloned
YPO3069
16123246
-
putative exported protein
486
Virulence
Phase 1: October 2007
3C37
15%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
2'-Deoxyribonucleotide metabolism
IDP00228
(
show subtarget assignments
)
1
cloned
YPO3388
16123537
-
putative chloride channel protein
441
Virulence
Phase 1: October 2007
1KPL
76.6%
Yersinia pestis
Transcription
Transcription factors
IDP00232
(
show subtarget assignments
)
1
cloned
YPO3480
16123626
-
conserved hypothetical protein
292
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP00233
(
show subtarget assignments
)
1
cloned
YPO3676
16123819
-
putative phage-related protein
133
Virulence
Phase 1: October 2007
2VO9
25.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00251
(
show subtarget assignments
)
1
cloned
MVEVgp1
9633623
Murray Valley encephalitis Envelope prot...
407
Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...
Phase 1: October 2007
3P54
78.1%
Murray Valley
IDP00263
(
show subtarget assignments
)
1
cloned
AF180817_1-114
7329982
N/A
Capsid protein (C)
114
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.5%
Dengue virus
Unclassified
N/A
IDP00266
(
show subtarget assignments
)
1
cloned
AAX48017_114-279
61652905
N/A
Premembrane/Membrane protein (prM)
166
Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds
Phase 3: June 2008
3C5X
57.2%
Dengue virus
N/A
IDP00267
(
show subtarget assignments
)
1
cloned
AAX48017_4-113
61652905
N/A
Capsid protein (C)
111
Encapsidation of genomic RNA
Phase 3: June 2008
1R6R
60.4%
Dengue virus
Unclassified
N/A
IDP00268
(
show subtarget assignments
)
1
cloned
AAX48017_2488-3387
61652905
N/A
NS5 methyl transferase and RNA polymeras...
900
RNA-dependent RNA polymerase
Phase 3: June 2008
2J7U
54.7%
Dengue virus
Transcription
N/A
IDP00269
(
show subtarget assignments
)
1
cloned
AF180817_776-1127
7329982
N/A
NS1
352
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00270
(
show subtarget assignments
)
1
cloned
AF180817_2245-2493
7329982
N/A
NS4B
249
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00275
(
show subtarget assignments
)
1
cloned
NP_056776_776-1127
159024209
N/A
NS1
352
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00281
(
show subtarget assignments
)
1
cloned
AAX48017_776-1130
61652905
N/A
NS1
355
Secreted from infected cells; stimulates protective immune responses (reason for...
Phase 3: June 2008
Dengue virus
host defense modulator
N/A
IDP00282
(
show subtarget assignments
)
1
cloned
AAX48017_2243-2483
61652905
N/A
NS4B
241
possibly RNA replication
Phase 3: June 2008
Dengue virus
Transcription
N/A
IDP00300
(
show subtarget assignments
)
1
cloned
CBU_1153
548
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 2: March 2008
1GXB
10.4%
Coxiella burnetii
IDP00305
(
show subtarget assignments
)
1
cloned
CBU_0118
29653476
pbpB
penicillin-binding protein 3
548
Drug Target Function
Phase 2: March 2008
3OC2
45.3%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00317
(
show subtarget assignments
)
1
cloned
CBU_1887
29655172
ponA
penicillin-binding protein 1A
793
Drug Target Function
Phase 2: March 2008
3UDF
40.4%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00318
(
show subtarget assignments
)
1
cloned
CBU_1947
29655231
glmU
UDP-N-acetylglucosamine pyrophosphorylas...
455
Drug Target Function
Phase 2: March 2008
1HV9
51.4%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00324
(
show subtarget assignments
)
1
cloned
Cj1366c
15792689
glmS
D-fructose-6-phosphate amidotransferase ...
598
Drug Target Function
Phase 2: March 2008
1JXA
41.3%
Campylobacter jejuni
Unclassified
Unclassified
IDP00329
(
show subtarget assignments
)
1
cloned
Cj1724c
15793027
7-cyano-7-deazaguanine reductase
127
Drug Target Function
Phase 2: March 2008
Campylobacter jejuni
Amino acid biosynthesis
Pyruvate family
IDP00336
(
show subtarget assignments
)
1
cloned
FTT1186
56708252
smpB
SsrA-binding protein
157
Drug Target Function
Phase 2: March 2008
1P6V
48.4%
Francisella tularensis
Protein synthesis
Other
IDP00338
(
show subtarget assignments
)
1
cloned
FTT0876c
56707980
aroC
chorismate synthase
352
Drug Target Function
Phase 2: March 2008
1UM0
47.4%
Francisella tularensis
Amino acid biosynthesis
Aromatic amino acid family
IDP00341
(
show subtarget assignments
)
1
cloned
FTT1305c
56708363
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
444
Drug Target Function
Phase 2: March 2008
3SG1
32.7%
Francisella tularensis
IDP00342
(
show subtarget assignments
)
1
cloned
FTT1802c
56708788
trpE
anthranilate synthase component I
514
Drug Target Function
Phase 2: March 2008
1I1Q
51.1%
Francisella tularensis
Amino acid biosynthesis
Aromatic amino acid family
IDP00344
(
show subtarget assignments
)
1
cloned
lmo2039
16804078
pbpB
hypothetical protein lmo2039
751
Drug Target Function
Phase 2: March 2008
1RP5
34.1%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00345
(
show subtarget assignments
)
1
cloned
lmo0441
16802485
hypothetical protein lmo0441
678
Drug Target Function
Phase 2: March 2008
1MWR
35.3%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00346
(
show subtarget assignments
)
1
cloned
lmo0489
16802532
hypothetical protein lmo0489
664
Drug Target Function
Phase 2: March 2008
3K30
26.6%
Listeria monocytogenes
Energy metabolism
Electron transport
IDP00354
(
show subtarget assignments
)
1
cloned
lmo2471
16804509
hypothetical protein lmo2471
338
Drug Target Function
Phase 2: March 2008
1Z41
62.4%
Listeria monocytogenes
Fatty acid and phospholipid metabolism
Degradation
IDP00358
(
show subtarget assignments
)
1
cloned
lmo2229
16804268
hypothetical protein lmo2229
714
Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs
Phase 2: March 2008
3UDF
29.7%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00359
(
show subtarget assignments
)
1
cloned
lmo2552
16804590
murZ
UDP-N-acetylglucosamine 1-carboxyvinyltr...
423
Drug Target Function
Phase 2: March 2008
3SG1
50.6%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00401
(
show subtarget assignments
)
1
cloned
YPO2490
161486873
putative hemolysin
2531
Virulence Associated Factor
Phase 2: March 2008
1RWR
3.9%
Yersinia pestis
Viral functions
General
IDP00406
(
show subtarget assignments
)
1
cloned
YPO3410
16123559
hypothetical protein YPO3410
115
Virulence Associated Factor
Phase 2: March 2008
3UTK
26.1%
Yersinia pestis
Cell envelope
Other
IDP00408
(
show subtarget assignments
)
1
cloned
YPO2735
16122939
ccmB
heme exporter protein B
219
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP00410
(
show subtarget assignments
)
1
cloned
YPO0548
16120876
ftsL
cell division protein FtsL
105
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP00417
(
show subtarget assignments
)
1
cloned
YPO2604
16122817
pbpA
penicillin-binding protein 2
631
Drug Target Function
Phase 2: March 2008
3OC2
26.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00434
(
show subtarget assignments
)
1
cloned
YPO0796
16121108
lysA
diaminopimelate decarboxylase
420
Drug Target Function
Phase 2: March 2008
1KNW
76.9%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP00436
(
show subtarget assignments
)
1
cloned
YPO3358
16123508
surE
stationary phase survival protein SurE
254
Conserved Gene / Pathway
Phase 2: March 2008
2V4N
79.9%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP00444
(
show subtarget assignments
)
1
cloned
YPO0342
16120677
putative oxidoreductase Fe-S binding sub...
671
Drug Target Function
Phase 2: March 2008
2VDC
28.8%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP00447
(
show subtarget assignments
)
1
cloned
YPCD1.71c
16082759
yopJ
targeted effector protein
288
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP00449
(
show subtarget assignments
)
1
cloned
YPO2706
16122910
yplA
phospholipase A
320
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00450
(
show subtarget assignments
)
1
cloned
YPCD1.40
16082728
yscN
type III secretion system ATPase
439
Virulence Associated Factor
Phase 2: March 2008
2DPY
42.8%
Yersinia pestis
Energy metabolism
ATP-proton motive force interconversion
IDP00459
(
show subtarget assignments
)
1
cloned
YPO3371
16123520
cysI
sulfite reductase [NADPH] hemoprotein be...
576
Conserved Gene / Pathway
Phase 2: March 2008
1AOP
68.4%
Yersinia pestis
Central intermediary metabolism
Sulfur metabolism
IDP00465
(
show subtarget assignments
)
1
cloned
YPO1062
16121362
tilS
tRNA(Ile)-lysidine synthetase
460
Virulence Associated Factor
Phase 2: March 2008
1NI5
52.8%
Yersinia pestis
Cellular processes
Cell division
IDP00466
(
show subtarget assignments
)
1
cloned
YPO1536
16121809
putative iron-siderophore transport syst...
359
Conserved Gene / Pathway
Phase 2: March 2008
3MWF
12.3%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP00469
(
show subtarget assignments
)
1
cloned
YPO0139
16120482
hslO
Hsp33-like chaperonin
293
Conserved Gene / Pathway
Phase 2: March 2008
1I7F
71%
Yersinia pestis
Protein fate
Protein folding and stabilization
IDP00473
(
show subtarget assignments
)
1
cloned
YPO0107
16120454
ftsN
cell division protein FtsN
281
Conserved Gene / Pathway
Phase 2: March 2008
1UTA
15.3%
Yersinia pestis
Cellular processes
Cell division
IDP00484
(
show subtarget assignments
)
1
cloned
YPO1417
16121697
putative iron-sulfur binding protein
370
Conserved Gene / Pathway
Phase 2: March 2008
2PIA
7%
Yersinia pestis
Energy metabolism
Electron transport
IDP00490
(
show subtarget assignments
)
1
cloned
YPO1537
16121810
putative iron-siderophore receptor
753
Conserved Gene / Pathway
Phase 2: March 2008
3EFM
36%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP00496
(
show subtarget assignments
)
1
cloned
YPO1699
16121959
hypothetical protein YPO1699
176
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Other
IDP00498
(
show subtarget assignments
)
1
cloned
YPO0166
16120509
putative glycosyl hydrolase
437
Drug Target Function
Phase 2: March 2008
1S6Y
52.6%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP00512
(
show subtarget assignments
)
1
cloned
YPO2244
16122472
electron transport complex protein RnfC ...
620
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Unclassified
Role category not yet assigned
IDP00513
(
show subtarget assignments
)
1
cloned
YPO3674
16123817
putative insecticidal toxin
1011
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00515
(
show subtarget assignments
)
1
cloned
YPO3922
16124053
hemophore HasA
205
Virulence Associated Factor
Phase 2: March 2008
1B2V
29.8%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP00518
(
show subtarget assignments
)
1
cloned
YPO1566
16121836
putative hydrolase
280
Virulence Associated Factor
Phase 2: March 2008
3QDF
31.8%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00519
(
show subtarget assignments
)
1
cloned
YPO3446
16123594
argI
ornithine carbamoyltransferase subunit I...
335
Conserved Gene / Pathway
Phase 2: March 2008
1AKM
79.1%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP00525
(
show subtarget assignments
)
1
cloned
YPMT1.83
16082875
caf1A
putative F1 capsule anchoring protein
833
Virulence Associated Factor
Phase 2: March 2008
3RFZ
35.3%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00530
(
show subtarget assignments
)
1
cloned
YPO2736
16122940
ccmC
putative heme exporter protein C
245
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Other
IDP00531
(
show subtarget assignments
)
1
cloned
YPO2737
16122941
ccmD
putative heme exporter protein D
100
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Other
IDP00542
(
show subtarget assignments
)
1
cloned
YPO2744
16122948
fadL
long-chain fatty acid outer membrane tra...
423
Virulence Associated Factor
Phase 2: March 2008
1T16
64%
Yersinia pestis
Cell envelope
Other
IDP00545
(
show subtarget assignments
)
1
cloned
YPO2747
16122951
fadJ
multifunctional fatty acid oxidation com...
774
Conserved Gene / Pathway
Phase 2: March 2008
1WDK
34.1%
Yersinia pestis
Cellular processes
Detoxification
IDP00548
(
show subtarget assignments
)
1
cloned
YPO0549
16120877
ftsI
penicillin-binding protein 3
587
Drug Target Function
Phase 2: March 2008
3OC2
41.4%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00556
(
show subtarget assignments
)
1
cloned
YPO2686
16122891
pgm
phosphoglucomutase
547
Drug Target Function
Phase 2: March 2008
2FUV
82.4%
Yersinia pestis
Energy metabolism
Sugars
IDP00572
(
show subtarget assignments
)
1
cloned
YPO2717
16122921
lepB
lsignal peptidase I
332
Drug Target Function
Phase 2: March 2008
1T7D
54.8%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP00574
(
show subtarget assignments
)
1
cloned
YPO0531
16120860
leuC
isopropylmalate isomerase large subunit ...
476
Virulence Associated Factor
Phase 2: March 2008
1ACO
25%
Yersinia pestis
Amino acid biosynthesis
Pyruvate family
IDP00576
(
show subtarget assignments
)
1
cloned
YPO1398
16121678
cspB
cold shock-like protein
69
Virulence Associated Factor
Phase 2: March 2008
3I2Z
50.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP00579
(
show subtarget assignments
)
1
cloned
YPO1122
16121422
tolR
colicin uptake protein TolR
142
Conserved Gene / Pathway
Phase 2: March 2008
2JWK
23.9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00583
(
show subtarget assignments
)
1
cloned
YPO2752
16122956
mepA
penicillin-insensitive murein endopeptid...
275
Drug Target Function
Phase 2: March 2008
1TZP
67.6%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00587
(
show subtarget assignments
)
1
cloned
YPO1507
16121780
mglB
galactose-binding protein
335
Virulence Associated Factor
Phase 2: March 2008
1GCA
80.9%
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP00590
(
show subtarget assignments
)
1
cloned
YPO1078
16121379
mltD
predicted membrane-bound lytic murein tr...
475
Drug Target Function
Phase 2: March 2008
1E0G
7.8%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
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