Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04611 (show subtarget assignments)	1	cloned	BAS3754	49186753		sporulation sigma factor SigG [Bacillus ...	289	Proposed to be essential proteins	Phase 4: April 2009	1L0O	37%	Bacillus anthracis

IDP91272 (show subtarget assignments)	8	selected	NT05BA3926	49180681		RNA polymerase sigma-29 factor [Bacillus...	239	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L0O	31.4%	Bacillus anthracis

IDP05359 (show subtarget assignments)	1	soluble	BA_1311	30255254		putative lipoprotein [Bacillus anthracis...	324	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1L0Q	21.6%	Bacillus anthracis	Cell envelope: Other

IDP91722 (show subtarget assignments)	8	selected	NP_112420	14043070	HNRNPA1	heterogeneous nuclear ribonucleoprotein ...	372	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1L3K	52.7%	Homo sapiens

IDP00858 (show subtarget assignments)	1	purified	STM1342	16764693	btuD	vitamin B12-transporter ATPase	249	Conserved Gene / Pathway	Phase 2: March 2008	1L7V	80.3%	Salmonella enterica	Transport and binding proteins	Other

IDP02700 (show subtarget assignments)	1	cloned	YPO3419	16123568	aceE	pyruvate dehydrogenase subunit E1 [Yersi...	887	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1L8A	89.1%	Yersinia pestis	Energy metabolism	Pyruvate dehydrogenase

IDP00092 (show subtarget assignments)	1	expressed	NT01SF0466	30040219	hemH	ferrochelatase	320	Essential	Phase 1: October 2007	1L8X	27.9%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP91278 (show subtarget assignments)	8	selected	NT05BA4419	49181159		RNA polymerase sigma-27 factor [Bacillus...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L9U	30.8%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP01177 (show subtarget assignments)	1	cloned	BA_4515	30259020	sigA	RNA polymerase sigma-43 factor	373	Conserved Gene / Pathway	Phase 2: March 2008	1L9U	51.2%	Bacillus anthracis	Transcription	Transcription factors

IDP01430 (show subtarget assignments)	1	purified	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02718 (show subtarget assignments)	1	cloned	GBAA3833	47529118	glnA	glutamine synthetase, type I [Bacillus a...	444	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1LGR	44.6%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP04700 (show subtarget assignments)	1	cloned	YPO0045	218927266	pyrE	orotate phosphoribosyltransferase [Yersi...	215	conserved gene; putative drug target function;	Phase 4: April 2009	1LH0	85.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04578 (show subtarget assignments)	1	cloned	BAS0089	49183123		cysteinyl-tRNA synthetase [Bacillus anth...	465	Proposed to be essential proteins	Phase 4: April 2009	1LI5	45.6%	Bacillus anthracis

IDP05660 (show subtarget assignments)	1	cloned	lmo0239	16802285	cysS	cysteinyl-tRNA synthetase [Listeria mono...	446	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1LI5	43.7%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90577 (show subtarget assignments)	8	soluble	VC1848	15641850	cysS	cysteinyl-tRNA synthetase [Vibrio choler...	459	Predicted Essential	Community Requests	1LI5	75.1%	Vibrio cholerae

IDP90916 (show subtarget assignments)	8	soluble	YPO3073	16123250	cysS	cysteinyl-tRNA synthetase [Yersinia pest...	461	Predicted Essential	Community Requests	1LI5	83.9%	Yersinia pestis

IDP01996 (show subtarget assignments)	1	purified	STM3136	16766436		putative D-mannonate oxidoreductase [Sal...	490	Conserved; Drug target functions	Phase 3: June 2008	1LJ8	40.6%	Salmonella enterica	Energy metabolism	Other

IDP00826 (show subtarget assignments)	0	work_stopped	SACOL2422	57285152	hlgB	gamma hemolysin, component B	325	Conserved Gene / Pathway	Phase 2: March 2008	1LKF	92%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00813 (show subtarget assignments)	1	expressed	SACOL2004	57284879		leukocidin subunit precursor, putative	290	Conserved Gene / Pathway	Phase 2: March 2008	1LKF	41.2%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04413 (show subtarget assignments)	1	cloned	VC2373	15642370		glutamate synthase, large subunit [Vibri...	1530	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1LLW	44.6%	Vibrio cholerae	Amino acid biosynthesis	Glutamate family

IDP01624 (show subtarget assignments)	1	expressed	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	Phase 3: June 2008	1LM6	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP05475 (show subtarget assignments)	1	expressed	BA_2860	30257458		hydrolase, CocE/NonD family [Bacillus an...	597	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1LNS	30.7%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP01757 (show subtarget assignments)	1	soluble	YPO3509	16123655	obgE	GTPase ObgE [Yersinia pestis CO92]	390	Conserved; CD; Drug target functions	Phase 3: June 2008	1LNZ	40.8%	Yersinia pestis	Unknown function	General

IDP04204 (show subtarget assignments)	1	soluble	CPF_2382	110799414	obgE	GTPase ObgE [Clostridium perfringens ATC...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1LNZ	44.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00679 (show subtarget assignments)	1	purified	SACOL1699	57284711	obgE	GTPase ObgE	430	Drug Target Function	Phase 2: March 2008	1LNZ	54.2%	Staphylococcus aureus	Unknown function	General

IDP04532 (show subtarget assignments)	1	cloned	STM3301_1_390	16766597	obgE	GTPase ObgE [Salmonella typhimurium LT2]...	390	Salmonella essential protein	Phase 4: April 2009	1LNZ	42.1%	Salmonella enterica

IDP01429 (show subtarget assignments)	1	purified	VC1849	15641851		peptidyl-prolyl cis-trans isomerase B	164	Conserved Gene / Pathway	Phase 2: March 2008	1LOP	64%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP04262 (show subtarget assignments)	1	cloned	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00823 (show subtarget assignments)	1	purified	SACOL2409	57285140	fmhA	fmhA protein	416	Drug Target Function	Phase 2: March 2008	1LRZ	43.3%	Staphylococcus aureus	Cell envelope	Other

IDP00822 (show subtarget assignments)	1	purified	SACOL2253	57285032	femX	femX protein	421	Conserved Gene / Pathway	Phase 2: March 2008	1LRZ	26.7%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02155 (show subtarget assignments)	1	purified	YPO0239	16120577	trkA	potassium transporter peripheral membran...	458	Conserved; CD; Drug target functions	Phase 3: June 2008	1LSS	12.2%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP91958 (show subtarget assignments)	8	selected	SpneCM_010100004562	298254871		Trk family potassium uptake protein [Str...	221	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1LSU	20.8%	Streptococcus pneumoniae

IDP91671 (show subtarget assignments)	8	selected	VK03_VACCC	0			88	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1LUZ	98.9%	Vaccinia virus

IDP90187 (show subtarget assignments)	8	cloned	AAM13490.1	20153029	CPXV043 CDS	CPXV043 protein	88	IFN resistance, K3L like	Community Requests	1LUZ	90.9%	Cowpox virus	host defense modulator	0

IDP00872 (show subtarget assignments)	1	cloned	STM0138	16763528	yacG	zinc-binding protein	63	Conserved Gene / Pathway	Phase 2: March 2008	1LV3	85.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP04722 (show subtarget assignments)	1	purified	YPO1357	115347116	ltaA	L-allo-threonine aldolase [Yersinia pest...	339	conserved gene; putative drug target function;	Phase 4: April 2009	1LW4	46.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01019 (show subtarget assignments)	0	work_stopped	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01449 (show subtarget assignments)	1	purified	VC2248	15642246		UDP-N-acetylglucosamine acyltransferase ...	262	Drug Target Function	Phase 2: March 2008	1LXA	68.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90556 (show subtarget assignments)	8	cloned	YPO1056	16121356	lpxA	UDP-N-acetylglucosamine acyltransferase	262	Predicted Essential	Community Requests	1LXA	81.7%	Yersinia pestis

IDP01633 (show subtarget assignments)	1	soluble	FTT1569c	56708595	lpxA	UDP-N-acetylglucosamine acyltransferase ...	259	Conserved; Drug target functions	Phase 3: June 2008	1LXA	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05561 (show subtarget assignments)	1	cloned	lmo2026	16804065	-	peptidoglycan binding protein [Listeria ...	626	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M0Z	11%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP05552 (show subtarget assignments)	1	cloned	lmo0849	16802890	-	amidase [Listeria monocytogenes EGD-e]	616	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M21	27.6%	Listeria monocytogenes	Central intermediary metabolism: Other

IDP05166 (show subtarget assignments)	1	cloned	BA_1921	30256579		amidase family protein [Bacillus anthrac...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M21	36%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP01059 (show subtarget assignments)	1	soluble	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00527 (show subtarget assignments)	1	purified	YPO0129	16120472	bioH	putative biotin biosynthesis protein	258	Drug Target Function	Phase 2: March 2008	1M33	63.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04178 (show subtarget assignments)	1	expressed	VC2718	15642712		bioH protein [Vibrio cholerae O1 biovar ...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1M33	49.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90578 (show subtarget assignments)	8	expressed	YPO3401	16123550	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Predicted Essential	Community Requests	1M3U	75.9%	Yersinia pestis

IDP02674 (show subtarget assignments)	1	purified	GBAA1562	47777948	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	279	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1M3U	43%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00791 (show subtarget assignments)	1	selected	SACOL1178	57284463		superantigen-like protein	238	Virulence Associated Factor	Phase 2: March 2008	1M4V	23.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01012 (show subtarget assignments)	1	purified	STM2578	16765898	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Conserved Gene / Pathway	Phase 2: March 2008	1M5W	93.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP90553 (show subtarget assignments)	8	soluble	VC2458	15642454		pyridoxal phosphate biosynthetic protein...	243	Predicted Essential	Community Requests	1M5W	70.8%	Vibrio cholerae

IDP01432 (show subtarget assignments)	1	cloned	VC1918	15641920		peptidyl-prolyl cis-trans isomerse D	619	Drug Target Function	Phase 2: March 2008	1M5Y	16%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP04442 (show subtarget assignments)	8	soluble	YPO0494	115346303	b0053	survival protein SurA precursor (peptidy...	434	virulence/pathogenesis / drug target; conserved gene; putative drug target function;	Community Requests	1M5Y	71%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP91058 (show subtarget assignments)	8	soluble	FTT_0468	56707610	surA	peptidyl-prolyl cis-trans isomerase (PPI...	473	virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...	Community Requests	1M5Y	19.5%	Francisella tularensis

IDP01191 (show subtarget assignments)	1	purified	BA_0882	81837776		Protein translocase subunit secA 2	788	Conserved Gene / Pathway	Phase 2: March 2008	1M6N	48%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP00420 (show subtarget assignments)	1	soluble	YPO1207	16121498	katA	catalase	480	Virulence Associated Factor	Phase 2: March 2008	1M85	84.2%	Yersinia pestis	Cellular processes	Detoxification

IDP01859 (show subtarget assignments)	1	cloned	lmo2558	16804596	ami	autolysin, amidase [Listeria monocytogen...	917	Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838	Phase 3: June 2008	1M9S	14.7%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP05244 (show subtarget assignments)	1	soluble	lmo2203	16804242	-	hypothetical protein lmo2203 [Listeria m...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	22.6%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05328 (show subtarget assignments)	1	cloned	lmo2591	16804629	-	GW repeat-containing surface protein [Li...	508	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	17.7%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP91680 (show subtarget assignments)	8	selected	INLB_LISMO	0			630	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1M9S	93.7%	Listeria monocytogenes

IDP00005 (show subtarget assignments)	1	cloned	BA_0552	30254078		internalin, putative	1070	Virulence/Drug Target Homolog	Phase 1: October 2007	1M9S	13.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP05076 (show subtarget assignments)	1	soluble	lmo0801	16802843	-	hypothetical protein lmo0801 [Listeria m...	646	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	22.1%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP02719 (show subtarget assignments)	1	cloned	lmo0262	16802308	inlG	internalin G [Listeria monocytogenes EGD...	490	Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815	Phase 3: June 2008	1M9S	31.6%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP05549 (show subtarget assignments)	1	cloned	lmo0549	16802592	-	hypothetical protein lmo0549 [Listeria m...	673	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	14.6%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP05510 (show subtarget assignments)	1	soluble	CD1303	126698901		NAD-dependent deacetylase [Clostridium d...	245	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MA3	40.8%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02071 (show subtarget assignments)	1	expressed	CBU_1388	29541953	map	methionine aminopeptidase, type I [Coxie...	258	Conserved; Drug target functions	Phase 3: June 2008	1MAT	65.1%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP04451 (show subtarget assignments)	1	cloned	YPO1043	218928211	ampM	methionine aminopeptidase [Yersinia pest...	263	drug target; putative drug target function;	Phase 4: April 2009	1MAT	84%	Yersinia pestis	Protein fate	Protein modification and repair

IDP01338 (show subtarget assignments)	1	purified	VC2261	15642259		methionine aminopeptidase	280	Drug Target Function	Phase 2: March 2008	1MAT	57.5%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01078 (show subtarget assignments)	1	soluble	STM4137	16767396	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	342	Essential Gene	Phase 2: March 2008	1MBB	82.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00595 (show subtarget assignments)	1	purified	YPO3760	16123897	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	345	Drug Target Function	Phase 2: March 2008	1MBB	60.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00198 (show subtarget assignments)	1	cloned	YPO1367	16121647	-	conserved hypothetical protein	106	Similar to Essential SALTY	Phase 1: October 2007	1MBU	84.9%	Yersinia pestis

IDP90675 (show subtarget assignments)	8	cloned	YPO3861	16123996	rffH	glucose-1-phosphate thymidylyltransferas...	293	Predicted Essential	Community Requests	1MC3	86.7%	Yersinia pestis

IDP91640 (show subtarget assignments)	8	cloned	NP_216900	15609521		bifunctional salicyl-AMP ligase/salicyl-...	565	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1MD9	42.1%	Mycobacterium tuberculosis

IDP04093 (show subtarget assignments)	1	purified	YPO1907	218929023	irp5	yersiniabactin siderophore biosynthetic ...	525	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1MD9	47.8%	Yersinia pestis	Cellular processes	Cell division

IDP04676 (show subtarget assignments)	1	soluble	GBAA2370	47527665	dhbE	2,3-dihydroxybenzoate-AMP ligase [Bacill...	538	putative drug target function;	Phase 4: April 2009	1MD9	71.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01400 (show subtarget assignments)	1	expressed	VC0772	15640791		vibriobactin-specific 2,3-dihydroxybenzo...	543	Conserved Gene / Pathway	Phase 2: March 2008	1MD9	51.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02085 (show subtarget assignments)	1	purified	STM3204	16766504	cca	multifunctional tRNA nucleotidyl transfe...	413	Conserved; Essential; Drug target functions	Phase 3: June 2008	1MIV	29.1%	Salmonella enterica	Transcription	Degradation of RNA

IDP90146 (show subtarget assignments)	8	soluble	MPXV_ZAI1979_005_193	68449265		ankyrin-like protein [Monkeypox virus]	789	similar to VACV-COP-B20R, MPXV-ZAI96-B17R	Community Requests	1MJ0	5.2%	Monkeypox virus

IDP00848 (show subtarget assignments)	1	purified	SACOL1753	57286190		universal stress protein family	137	Conserved Gene / Pathway	Phase 2: March 2008	1MJH	33.5%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP90635 (show subtarget assignments)	8	crystallized	VC1483	15641492		3-hydroxydecanoyl-(acyl carrier protein)...	172	Predicted Essential	Community Requests	1MKA	77.9%	Vibrio cholerae

IDP01221 (show subtarget assignments)	1	expressed	BA_3990	30258499	fabD	malonyl CoA-acyl carrier protein transac...	314	Drug Target Function	Phase 2: March 2008	1MLA	44.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04281 (show subtarget assignments)	1	cloned	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00936 (show subtarget assignments)	1	soluble	STM0793	16764156	bioA	adenosylmethionine--8-amino-7-oxononanoa...	429	Conserved Gene / Pathway	Phase 2: March 2008	1MLY	86.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90614 (show subtarget assignments)	8	purified	VC0013	15640045		DNA polymerase III subunit beta [Vibrio ...	366	Predicted Essential	Community Requests	1MMI	63.9%	Vibrio cholerae

IDP90654 (show subtarget assignments)	8	expressed	YPO0474	16120803	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Predicted Essential	Community Requests	1MRZ	32.1%	Yersinia pestis

IDP00902 (show subtarget assignments)	1	expressed	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02555 (show subtarget assignments)	1	expressed	CBU_0391	29541001	ribF	riboflavin biosynthesis protein RibF [Co...	320	Conserved; Drug target functions	Phase 3: June 2008	1MRZ	33.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05514 (show subtarget assignments)	1	purified	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01850 (show subtarget assignments)	1	cloned	FTT0916c	56708017	ribF	riboflavin biosynthesis protein RibF [Fr...	306	Drug Target	Phase 3: June 2008	1MRZ	30.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04156 (show subtarget assignments)	1	expressed	VC0681	9655120		riboflavin kinase/FMN adenylyltransferas...	322	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1MRZ	32.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91421 (show subtarget assignments)	8	soluble	VV1_0568	27364030		NTP pyrophosphohydrolase [Vibrio vulnifi...	133	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1MUT	42.9%	Vibrio vulnificus

IDP01244 (show subtarget assignments)	1	cloned	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01258 (show subtarget assignments)	1	soluble	BA_2238	30256883	pbpC	penicillin-binding protein 3	661	Drug Target Function	Phase 2: March 2008	1MWR	34.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00345 (show subtarget assignments)	1	cloned	lmo0441	16802485		hypothetical protein lmo0441	678	Drug Target Function	Phase 2: March 2008	1MWR	35.3%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00320 (show subtarget assignments)	1	expressed	CBU_0550	29653890	pbpA	penicillin-binding protein 2	612	Drug Target Function	Phase 2: March 2008	1MWR	25.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01655 (show subtarget assignments)	1	purified	FTT0721c	56707839	katG	peroxidase/catalase [Francisella tularen...	741	Drug Target	Phase 3: June 2008	1MWV	53.3%	Francisella tularensis	Cellular processes	Detoxification

IDP01075 (show subtarget assignments)	1	cloned	STM4106	16767372	katG	hydroperoxidase	726	Essential Gene	Phase 2: March 2008	1MWV	64.3%	Salmonella enterica	Cellular processes	Detoxification

IDP90110 (show subtarget assignments)	8	soluble	MPXV_ZAI1979_005_015	68449089		ankyrin-like protein [Monkeypox virus]	660	similar to CPXV-GRI-C9L,CPXV-BR-V024, MPXV-ZAI96-D7L	Community Requests	1N0Q	4.4%	Monkeypox virus

IDP90216 (show subtarget assignments)	8	expressed	MYXV_gp008	9633799	m005L	m005L, m5, M-T5	483	ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.	Community Requests	1N0R	8.5%	Myxoma virus	host range factor, host defense modulator	0

IDP90178 (show subtarget assignments)	8	purified	AAM13472.1	20153011	VHR1	VHR1 or CPXV025 protein	668	ankyrin-like protein, CP77	Community Requests	1N11	10%	Cowpox virus	host range protein	0

IDP04611
(show subtarget assignments)

1

cloned

BAS3754

49186753

sporulation sigma factor SigG [Bacillus ...

289

Proposed to be essential proteins

Phase 4: April 2009

1L0O

37%

Bacillus anthracis

IDP91272
(show subtarget assignments)

8

selected

NT05BA3926

49180681

RNA polymerase sigma-29 factor [Bacillus...

239

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L0O

31.4%

Bacillus anthracis

IDP05359
(show subtarget assignments)

1

soluble

BA_1311

30255254

putative lipoprotein [Bacillus anthracis...

324

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1L0Q

21.6%

Bacillus anthracis

Cell envelope: Other

IDP91722
(show subtarget assignments)

8

selected

NP_112420

14043070

HNRNPA1

heterogeneous nuclear ribonucleoprotein ...

372

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1L3K

52.7%

Homo sapiens

IDP00858
(show subtarget assignments)

1

purified

STM1342

16764693

btuD

vitamin B12-transporter ATPase

249

Conserved Gene / Pathway

Phase 2: March 2008

1L7V

80.3%

Salmonella enterica

Transport and binding proteins

Other

IDP02700
(show subtarget assignments)

1

cloned

YPO3419

16123568

aceE

pyruvate dehydrogenase subunit E1 [Yersi...

887

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1L8A

89.1%

Yersinia pestis

Energy metabolism

Pyruvate dehydrogenase

IDP00092
(show subtarget assignments)

1

expressed

NT01SF0466

30040219

hemH

ferrochelatase

320

Essential

Phase 1: October 2007

1L8X

27.9%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP91278
(show subtarget assignments)

8

selected

NT05BA4419

49181159

RNA polymerase sigma-27 factor [Bacillus...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L9U

30.8%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP01177
(show subtarget assignments)

1

cloned

BA_4515

30259020

sigA

RNA polymerase sigma-43 factor

373

Conserved Gene / Pathway

Phase 2: March 2008

1L9U

51.2%

Bacillus anthracis

Transcription

Transcription factors

IDP01430
(show subtarget assignments)

1

purified

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02718
(show subtarget assignments)

1

cloned

GBAA3833

47529118

glnA

glutamine synthetase, type I [Bacillus a...

444

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1LGR

44.6%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP04700
(show subtarget assignments)

1

cloned

YPO0045

218927266

pyrE

orotate phosphoribosyltransferase [Yersi...

215

conserved gene; putative drug target function;

Phase 4: April 2009

1LH0

85.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04578
(show subtarget assignments)

1

cloned

BAS0089

49183123

cysteinyl-tRNA synthetase [Bacillus anth...

465

Proposed to be essential proteins

Phase 4: April 2009

1LI5

45.6%

Bacillus anthracis

IDP05660
(show subtarget assignments)

1

cloned

lmo0239

16802285

cysS

cysteinyl-tRNA synthetase [Listeria mono...

446

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1LI5

43.7%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90577
(show subtarget assignments)

8

soluble

VC1848

15641850

cysS

cysteinyl-tRNA synthetase [Vibrio choler...

459

Predicted Essential

Community Requests

1LI5

75.1%

Vibrio cholerae

IDP90916
(show subtarget assignments)

8

soluble

YPO3073

16123250

cysS

cysteinyl-tRNA synthetase [Yersinia pest...

461

Predicted Essential

Community Requests

1LI5

83.9%

Yersinia pestis

IDP01996
(show subtarget assignments)

1

purified

STM3136

16766436

putative D-mannonate oxidoreductase [Sal...

490

Conserved; Drug target functions

Phase 3: June 2008

1LJ8

40.6%

Salmonella enterica

Energy metabolism

Other

IDP00826
(show subtarget assignments)

0

work_stopped

SACOL2422

57285152

hlgB

gamma hemolysin, component B

325

Conserved Gene / Pathway

Phase 2: March 2008

1LKF

92%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00813
(show subtarget assignments)

1

expressed

SACOL2004

57284879

leukocidin subunit precursor, putative

290

Conserved Gene / Pathway

Phase 2: March 2008

1LKF

41.2%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04413
(show subtarget assignments)

1

cloned

VC2373

15642370

glutamate synthase, large subunit [Vibri...

1530

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1LLW

44.6%

Vibrio cholerae

Amino acid biosynthesis

Glutamate family

IDP01624
(show subtarget assignments)

1

expressed

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

Phase 3: June 2008

1LM6

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP05475
(show subtarget assignments)

1

expressed

BA_2860

30257458

hydrolase, CocE/NonD family [Bacillus an...

597

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1LNS

30.7%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP01757
(show subtarget assignments)

1

soluble

YPO3509

16123655

obgE

GTPase ObgE [Yersinia pestis CO92]

390

Conserved; CD; Drug target functions

Phase 3: June 2008

1LNZ

40.8%

Yersinia pestis

Unknown function

General

IDP04204
(show subtarget assignments)

1

soluble

CPF_2382

110799414

obgE

GTPase ObgE [Clostridium perfringens ATC...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1LNZ

44.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00679
(show subtarget assignments)

1

purified

SACOL1699

57284711

obgE

GTPase ObgE

430

Drug Target Function

Phase 2: March 2008

1LNZ

54.2%

Staphylococcus aureus

Unknown function

General

IDP04532
(show subtarget assignments)

1

cloned

STM3301_1_390

16766597

obgE

GTPase ObgE [Salmonella typhimurium LT2]...

390

Salmonella essential protein

Phase 4: April 2009

1LNZ

42.1%

Salmonella enterica

IDP01429
(show subtarget assignments)

1

purified

VC1849

15641851

peptidyl-prolyl cis-trans isomerase B

164

Conserved Gene / Pathway

Phase 2: March 2008

1LOP

64%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP04262
(show subtarget assignments)

1

cloned

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00823
(show subtarget assignments)

1

purified

SACOL2409

57285140

fmhA

fmhA protein

416

Drug Target Function

Phase 2: March 2008

1LRZ

43.3%

Staphylococcus aureus

Cell envelope

Other

IDP00822
(show subtarget assignments)

1

purified

SACOL2253

57285032

femX

femX protein

421

Conserved Gene / Pathway

Phase 2: March 2008

1LRZ

26.7%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02155
(show subtarget assignments)

1

purified

YPO0239

16120577

trkA

potassium transporter peripheral membran...

458

Conserved; CD; Drug target functions

Phase 3: June 2008

1LSS

12.2%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP91958
(show subtarget assignments)

8

selected

SpneCM_010100004562

298254871

Trk family potassium uptake protein [Str...

221

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1LSU

20.8%

Streptococcus pneumoniae

IDP91671
(show subtarget assignments)

8

selected

VK03_VACCC

0

88

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1LUZ

98.9%

Vaccinia virus

IDP90187
(show subtarget assignments)

8

cloned

AAM13490.1

20153029

CPXV043 CDS

CPXV043 protein

88

IFN resistance, K3L like

Community Requests

1LUZ

90.9%

Cowpox virus

host defense modulator

0

IDP00872
(show subtarget assignments)

1

cloned

STM0138

16763528

yacG

zinc-binding protein

63

Conserved Gene / Pathway

Phase 2: March 2008

1LV3

85.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP04722
(show subtarget assignments)

1

purified

YPO1357

115347116

ltaA

L-allo-threonine aldolase [Yersinia pest...

339

conserved gene; putative drug target function;

Phase 4: April 2009

1LW4

46.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01019
(show subtarget assignments)

0

work_stopped

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01449
(show subtarget assignments)

1

purified

VC2248

15642246

UDP-N-acetylglucosamine acyltransferase ...

262

Drug Target Function

Phase 2: March 2008

1LXA

68.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90556
(show subtarget assignments)

8

cloned

YPO1056

16121356

lpxA

UDP-N-acetylglucosamine acyltransferase

262

Predicted Essential

Community Requests

1LXA

81.7%

Yersinia pestis

IDP01633
(show subtarget assignments)

1

soluble

FTT1569c

56708595

lpxA

UDP-N-acetylglucosamine acyltransferase ...

259

Conserved; Drug target functions

Phase 3: June 2008

1LXA

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05561
(show subtarget assignments)

1

cloned

lmo2026

16804065

-

peptidoglycan binding protein [Listeria ...

626

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M0Z

11%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP05552
(show subtarget assignments)

1

cloned

lmo0849

16802890

-

amidase [Listeria monocytogenes EGD-e]

616

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M21

27.6%

Listeria monocytogenes

Central intermediary metabolism: Other

IDP05166
(show subtarget assignments)

1

cloned

BA_1921

30256579

amidase family protein [Bacillus anthrac...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M21

36%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP01059
(show subtarget assignments)

1

soluble

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00527
(show subtarget assignments)

1

purified

YPO0129

16120472

bioH

putative biotin biosynthesis protein

258

Drug Target Function

Phase 2: March 2008

1M33

63.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04178
(show subtarget assignments)

1

expressed

VC2718

15642712

bioH protein [Vibrio cholerae O1 biovar ...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1M33

49.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90578
(show subtarget assignments)

8

expressed

YPO3401

16123550

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Predicted Essential

Community Requests

1M3U

75.9%

Yersinia pestis

IDP02674
(show subtarget assignments)

1

purified

GBAA1562

47777948

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

279

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1M3U

43%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00791
(show subtarget assignments)

1

selected

SACOL1178

57284463

superantigen-like protein

238

Virulence Associated Factor

Phase 2: March 2008

1M4V

23.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01012
(show subtarget assignments)

1

purified

STM2578

16765898

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Conserved Gene / Pathway

Phase 2: March 2008

1M5W

93.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP90553
(show subtarget assignments)

8

soluble

VC2458

15642454

pyridoxal phosphate biosynthetic protein...

243

Predicted Essential

Community Requests

1M5W

70.8%

Vibrio cholerae

IDP01432
(show subtarget assignments)

1

cloned

VC1918

15641920

peptidyl-prolyl cis-trans isomerse D

619

Drug Target Function

Phase 2: March 2008

1M5Y

16%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP04442
(show subtarget assignments)

8

soluble

YPO0494

115346303

b0053

survival protein SurA precursor (peptidy...

434

virulence/pathogenesis / drug target; conserved gene; putative drug target function;

Community Requests

1M5Y

71%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP91058
(show subtarget assignments)

8

soluble

FTT_0468

56707610

surA

peptidyl-prolyl cis-trans isomerase (PPI...

473

virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...

Community Requests

1M5Y

19.5%

Francisella tularensis

IDP01191
(show subtarget assignments)

1

purified

BA_0882

81837776

Protein translocase subunit secA 2

788

Conserved Gene / Pathway

Phase 2: March 2008

1M6N

48%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP00420
(show subtarget assignments)

1

soluble

YPO1207

16121498

katA

catalase

480

Virulence Associated Factor

Phase 2: March 2008

1M85

84.2%

Yersinia pestis

Cellular processes

Detoxification

IDP01859
(show subtarget assignments)

1

cloned

lmo2558

16804596

ami

autolysin, amidase [Listeria monocytogen...

917

Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838

Phase 3: June 2008

1M9S

14.7%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP05244
(show subtarget assignments)

1

soluble

lmo2203

16804242

-

hypothetical protein lmo2203 [Listeria m...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

22.6%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05328
(show subtarget assignments)

1

cloned

lmo2591

16804629

-

GW repeat-containing surface protein [Li...

508

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

17.7%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP91680
(show subtarget assignments)

8

selected

INLB_LISMO

0

630

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1M9S

93.7%

Listeria monocytogenes

IDP00005
(show subtarget assignments)

1

cloned

BA_0552

30254078

internalin, putative

1070

Virulence/Drug Target Homolog

Phase 1: October 2007

1M9S

13.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP05076
(show subtarget assignments)

1

soluble

lmo0801

16802843

-

hypothetical protein lmo0801 [Listeria m...

646

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

22.1%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP02719
(show subtarget assignments)

1

cloned

lmo0262

16802308

inlG

internalin G [Listeria monocytogenes EGD...

490

Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815

Phase 3: June 2008

1M9S

31.6%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP05549
(show subtarget assignments)

1

cloned

lmo0549

16802592

-

hypothetical protein lmo0549 [Listeria m...

673

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

14.6%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP05510
(show subtarget assignments)

1

soluble

CD1303

126698901

NAD-dependent deacetylase [Clostridium d...

245

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MA3

40.8%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02071
(show subtarget assignments)

1

expressed

CBU_1388

29541953

map

methionine aminopeptidase, type I [Coxie...

258

Conserved; Drug target functions

Phase 3: June 2008

1MAT

65.1%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP04451
(show subtarget assignments)

1

cloned

YPO1043

218928211

ampM

methionine aminopeptidase [Yersinia pest...

263

drug target; putative drug target function;

Phase 4: April 2009

1MAT

84%

Yersinia pestis

Protein fate

Protein modification and repair

IDP01338
(show subtarget assignments)

1

purified

VC2261

15642259

methionine aminopeptidase

280

Drug Target Function

Phase 2: March 2008

1MAT

57.5%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01078
(show subtarget assignments)

1

soluble

STM4137

16767396

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

342

Essential Gene

Phase 2: March 2008

1MBB

82.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00595
(show subtarget assignments)

1

purified

YPO3760

16123897

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

345

Drug Target Function

Phase 2: March 2008

1MBB

60.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00198
(show subtarget assignments)

1

cloned

YPO1367

16121647

-

conserved hypothetical protein

106

Similar to Essential SALTY

Phase 1: October 2007

1MBU

84.9%

Yersinia pestis

IDP90675
(show subtarget assignments)

8

cloned

YPO3861

16123996

rffH

glucose-1-phosphate thymidylyltransferas...

293

Predicted Essential

Community Requests

1MC3

86.7%

Yersinia pestis

IDP91640
(show subtarget assignments)

8

cloned

NP_216900

15609521

bifunctional salicyl-AMP ligase/salicyl-...

565

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1MD9

42.1%

Mycobacterium tuberculosis

IDP04093
(show subtarget assignments)

1

purified

YPO1907

218929023

irp5

yersiniabactin siderophore biosynthetic ...

525

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1MD9

47.8%

Yersinia pestis

Cellular processes

Cell division

IDP04676
(show subtarget assignments)

1

soluble

GBAA2370

47527665

dhbE

2,3-dihydroxybenzoate-AMP ligase [Bacill...

538

putative drug target function;

Phase 4: April 2009

1MD9

71.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01400
(show subtarget assignments)

1

expressed

VC0772

15640791

vibriobactin-specific 2,3-dihydroxybenzo...

543

Conserved Gene / Pathway

Phase 2: March 2008

1MD9

51.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02085
(show subtarget assignments)

1

purified

STM3204

16766504

cca

multifunctional tRNA nucleotidyl transfe...

413

Conserved; Essential; Drug target functions

Phase 3: June 2008

1MIV

29.1%

Salmonella enterica

Transcription

Degradation of RNA

IDP90146
(show subtarget assignments)

8

soluble

MPXV_ZAI1979_005_193

68449265

ankyrin-like protein [Monkeypox virus]

789

similar to VACV-COP-B20R, MPXV-ZAI96-B17R

Community Requests

1MJ0

5.2%

Monkeypox virus

IDP00848
(show subtarget assignments)

1

purified

SACOL1753

57286190

universal stress protein family

137

Conserved Gene / Pathway

Phase 2: March 2008

1MJH

33.5%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP90635
(show subtarget assignments)

8

crystallized

VC1483

15641492

3-hydroxydecanoyl-(acyl carrier protein)...

172

Predicted Essential

Community Requests

1MKA

77.9%

Vibrio cholerae

IDP01221
(show subtarget assignments)

1

expressed

BA_3990

30258499

fabD

malonyl CoA-acyl carrier protein transac...

314

Drug Target Function

Phase 2: March 2008

1MLA

44.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04281
(show subtarget assignments)

1

cloned

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00936
(show subtarget assignments)

1

soluble

STM0793

16764156

bioA

adenosylmethionine--8-amino-7-oxononanoa...

429

Conserved Gene / Pathway

Phase 2: March 2008

1MLY

86.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90614
(show subtarget assignments)

8

purified

VC0013

15640045

DNA polymerase III subunit beta [Vibrio ...

366

Predicted Essential

Community Requests

1MMI

63.9%

Vibrio cholerae

IDP90654
(show subtarget assignments)

8

expressed

YPO0474

16120803

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Predicted Essential

Community Requests

1MRZ

32.1%

Yersinia pestis

IDP00902
(show subtarget assignments)

1

expressed

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02555
(show subtarget assignments)

1

expressed

CBU_0391

29541001

ribF

riboflavin biosynthesis protein RibF [Co...

320

Conserved; Drug target functions

Phase 3: June 2008

1MRZ

33.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05514
(show subtarget assignments)

1

purified

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01850
(show subtarget assignments)

1

cloned

FTT0916c

56708017

ribF

riboflavin biosynthesis protein RibF [Fr...

306

Drug Target

Phase 3: June 2008

1MRZ

30.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04156
(show subtarget assignments)

1

expressed

VC0681

9655120

riboflavin kinase/FMN adenylyltransferas...

322

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1MRZ

32.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91421
(show subtarget assignments)

8

soluble

VV1_0568

27364030

NTP pyrophosphohydrolase [Vibrio vulnifi...

133

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1MUT

42.9%

Vibrio vulnificus

IDP01244
(show subtarget assignments)

1

cloned

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01258
(show subtarget assignments)

1

soluble

BA_2238

30256883

pbpC

penicillin-binding protein 3

661

Drug Target Function

Phase 2: March 2008

1MWR

34.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00345
(show subtarget assignments)

1

cloned

lmo0441

16802485

hypothetical protein lmo0441

678

Drug Target Function

Phase 2: March 2008

1MWR

35.3%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00320
(show subtarget assignments)

1

expressed

CBU_0550

29653890

pbpA

penicillin-binding protein 2

612

Drug Target Function

Phase 2: March 2008

1MWR

25.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01655
(show subtarget assignments)

1

purified

FTT0721c

56707839

katG

peroxidase/catalase [Francisella tularen...

741

Drug Target

Phase 3: June 2008

1MWV

53.3%

Francisella tularensis

Cellular processes

Detoxification

IDP01075
(show subtarget assignments)

1

cloned

STM4106

16767372

katG

hydroperoxidase

726

Essential Gene

Phase 2: March 2008

1MWV

64.3%

Salmonella enterica

Cellular processes

Detoxification

IDP90110
(show subtarget assignments)

8

soluble

MPXV_ZAI1979_005_015

68449089

ankyrin-like protein [Monkeypox virus]

660

Community Requests

1N0Q

4.4%

Monkeypox virus

IDP90216
(show subtarget assignments)

8

expressed

MYXV_gp008

9633799

m005L

m005L, m5, M-T5

483

ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.

Community Requests

1N0R

8.5%

Myxoma virus

host range factor, host defense modulator

0

IDP90178
(show subtarget assignments)

8

purified

AAM13472.1

20153011

VHR1

VHR1 or CPXV025 protein

668

ankyrin-like protein, CP77

Community Requests

1N11

10%

Cowpox virus

host range protein

0