Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91267 (show subtarget assignments)	8	selected	NT05BA2321	49179114		protein export protein prsA [Bacillus an...	283	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3RFW	25.4%	Bacillus anthracis	Protein fate: Protein folding and stabilization

IDP91940 (show subtarget assignments)	8	selected	SpneCM_010100006879	298255307		ABC transporter, ATP-binding protein [St...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	25.4%	Streptococcus pneumoniae

IDP05268 (show subtarget assignments)	1	cloned	lmo0366	16802411	-	hypothetical protein lmo0366 [Listeria m...	386	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3AT7	25.4%	Listeria monocytogenes	Cell envelope: Other

IDP91090 (show subtarget assignments)	8	cloned	aq_1546	15606685	kpsF	polysialic acid capsule expression prote...	322	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	25.5%	Aquifex aeolicus

IDP01215 (show subtarget assignments)	1	expressed	BA_3506	30258044		penicillin-binding protein, putative	345	Drug Target Function	Phase 2: March 2008	2QMI	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05264 (show subtarget assignments)	1	cloned	CD3257	126700876		putative polysaccharide deacetylase [Clo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1W17	25.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00860 (show subtarget assignments)	1	cloned	STM1910	16765252		putative penicillin-binding protein	623	Drug Target Function	Phase 2: March 2008	3PBN	25.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90242 (show subtarget assignments)	8	expressed	SA1814	15927582		succinyl-diaminopimelate desuccinylase [...	407	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3TX8	25.5%	Staphylococcus aureus

IDP04253 (show subtarget assignments)	1	purified	CPF_1800	110800480	prs	phosphoribosylpyrophosphate synthetase [...	364	conserved gene; putative drug target function;	Phase 4: April 2009	2C4K	25.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91959 (show subtarget assignments)	8	selected	SpneCM_010100000757	298254130		thioredoxin family protein [Streptococcu...	188	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3GL3	25.5%	Streptococcus pneumoniae

IDP01251 (show subtarget assignments)	1	cloned	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01900 (show subtarget assignments)	1	purified	STM0570	16763947	apeE	outer membrane esterase [Salmonella typh...	656	Drug target functions	Phase 3: June 2008	3KVN	25.5%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP90353 (show subtarget assignments)	8	expressed	CT198	15604918	oppA_3	oligopeptide binding protein [Chlamydia ...	518	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1UIU	25.5%	Chlamydia trachomatis

IDP00233 (show subtarget assignments)	1	cloned	YPO3676	16123819	-	putative phage-related protein	133	Virulence	Phase 1: October 2007	2VO9	25.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00532 (show subtarget assignments)	1	soluble	YPO2390	16122613	cfa	cyclopropane fatty acyl phospholipid syn...	383	Virulence Associated Factor	Phase 2: March 2008	1TPY	25.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02266 (show subtarget assignments)	1	purified	Cj0043	15791442	flgE	flagellar hook protein [Campylobacter je...	545	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	3A69	25.6%	Campylobacter jejuni	Cell envelope	Surface structures

IDP91962 (show subtarget assignments)	8	selected	SpneCM_010100007760	298255480		amino acid ABC transporter, amino acid-b...	266	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2YLN	25.6%	Streptococcus pneumoniae

IDP02388 (show subtarget assignments)	1	soluble	YPO1407	16121687		hypothetical protein YPO1407 [Yersinia p...	618	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1A9U	25.6%	Yersinia pestis	Cell envelope	Other

IDP02045 (show subtarget assignments)	1	cloned	FTT0749c	56707864		hypothetical protein FTT0749c [Francisel...	328	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AIM	25.6%	Francisella tularensis	Central intermediary metabolism	Other

IDP01799 (show subtarget assignments)	1	soluble	GBAA1127	47526398		S-layer protein, putative [Bacillus anth...	223	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.6%	Bacillus anthracis	Cell envelope	Surface structures

IDP90693 (show subtarget assignments)	8	purified	Cj1599	15792904	hisB	imidazole glycerol-phosphate dehydratase...	352	Predicted Essential	Community Requests	1RHY	25.6%	Campylobacter jejuni

IDP00674 (show subtarget assignments)	1	crystallized	SACOL1453	57286104	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	25.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02404 (show subtarget assignments)	1	cloned	GBAA2730	47528021		neutral protease [Bacillus anthracis str...	567	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	25.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05489 (show subtarget assignments)	1	cloned	CD0106	126697677	cwlD	germination-specific N-acetylmuramoyl-L-...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JWQ	25.6%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP01783 (show subtarget assignments)	1	expressed	FTT0824	56707935	arsC1	arsenate reductase [Francisella tularens...	117	Drug Target	Phase 3: June 2008	3GKX	25.6%	Francisella tularensis	Unknown function	General

IDP01903 (show subtarget assignments)	1	purified	STM0750	16764120	ybgF	hypothetical protein STM0750 [Salmonella...	262	Conserved; Drug target functions	Phase 3: June 2008	2WZ7	25.6%	Salmonella enterica	Unknown function	General

IDP02419 (show subtarget assignments)	1	purified	FTT1447c	56708489	manB	phosphomannomutase [Francisella tularens...	494	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2F7L	25.7%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP00972 (show subtarget assignments)	1	expressed	STM1743	16765087	oppD	oligopeptide transporter ATP-binding com...	335	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	25.7%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP91910 (show subtarget assignments)	8	selected	SpneCM_010100003565	298254678		surface protein PspC, partial [Streptoco...	187	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2GRX	25.7%	Streptococcus pneumoniae

IDP01160 (show subtarget assignments)	1	expressed	BA_4774	30259261		bacitracin ABC transporter, ATP-binding ...	307	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	25.7%	Bacillus anthracis	Transport and binding proteins	Other

IDP91528 (show subtarget assignments)	8	purified	lpg1841	52629179	com1	27 kDa outer membrane protein [Legionell...	261	virulence/pathogenesis / Lpg1841 is most closely related to the major antigen of Coxiella burnetti, and o...	Community Requests	3GYK	25.7%	Legionella pneumophila

IDP02130 (show subtarget assignments)	1	cloned	Cj1416c	15792734		putative sugar nucleotidyltransferase [C...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	25.7%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01890 (show subtarget assignments)	1	cloned	Cj0063c	15791455		ATPase, ParA family [Campylobacter jejun...	288	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1HYQ	25.7%	Campylobacter jejuni	Cell envelope	Other

IDP91988 (show subtarget assignments)	8	selected	SpneCM_010100007640	298255458		phosphate-binding protein PstS 1 (PBP 1)...	292	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1TWY	25.7%	Streptococcus pneumoniae

IDP90642 (show subtarget assignments)	8	purified	Cj0585	15791945	folP	dihydropteroate synthase [Campylobacter ...	380	Predicted Essential	Community Requests	1AJ0	25.8%	Campylobacter jejuni

IDP02683 (show subtarget assignments)	1	cloned	GBAA2008	47527306		ribosome-associated GTPase [Bacillus ant...	364	Conserved; Essential;	Phase 3: June 2008	1T9H	25.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP05691 (show subtarget assignments)	1	cloned	lmo1800	16803840	-	hypothetical protein lmo1800 [Listeria m...	298	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YWF	25.8%	Listeria monocytogenes	Energy metabolism: Sugars

IDP05525 (show subtarget assignments)	1	soluble	CD2550	126700167		putative sugar transporter, substrate-bi...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	25.8%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP01370 (show subtarget assignments)	1	soluble	VC0247	15640277		lipopolysaccharide/O-antigen transport p...	271	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	25.8%	Vibrio cholerae	Transport and binding proteins	Other

IDP05327 (show subtarget assignments)	1	cloned	lmo1504	16803544	alaS	alanyl-tRNA synthetase [Listeria monocyt...	879	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RIQ	25.8%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP91544 (show subtarget assignments)	8	selected	BAE54319	83627318	ereB	erythromycin esterase type II [Escherich...	419	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2QGM	25.8%	Escherichia coli

IDP02794 (show subtarget assignments)	1	purified	FTT0477c	56707619	birA	transcription repressor BirA [Francisell...	260	Conserved; Drug target functions	Phase 3: June 2008	1BIA	25.8%	Francisella tularensis	Protein fate	Protein modification and repair

IDP04133 (show subtarget assignments)	1	cloned	CPF_1195	110798868	hpkA	sensor histidine kinase [Clostridium per...	287	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	25.8%	Clostridium perfringens	Regulatory functions	Other

IDP91342 (show subtarget assignments)	8	expressed	VV2_0079	27366538		DNA repair exonuclease [Vibrio vulnificu...	377	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3QG5	25.8%	Vibrio vulnificus

IDP05345 (show subtarget assignments)	1	soluble	Z3383	12516442	pbpG	penicillin-binding protein 7 [Escherichi...	313	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1XP4	25.9%	Escherichia coli	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00483 (show subtarget assignments)	1	expressed	YPO1316	16121598		putative iron/ascorbate oxidoreductase f...	355	Virulence Associated Factor	Phase 2: March 2008	3OOX	25.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP05710 (show subtarget assignments)	1	cloned	SACOL1673	57650500	alaS	alanyl-tRNA synthetase [Staphylococcus a...	876	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RIQ	25.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05357 (show subtarget assignments)	1	soluble	BA_0382	30253917		putative ABC transporter, substrate-bind...	332	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	25.9%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP91512 (show subtarget assignments)	8	cloned	VV2_0404	27366843		cytolysin [Vibrio vulnificus CMCP6]	468	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XEZ	25.9%	Vibrio vulnificus

IDP02245 (show subtarget assignments)	1	cloned	GBAA1751	47527043	asnO-2	asparagine synthetase, glutamine-hydroly...	607	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CT9	25.9%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP90247 (show subtarget assignments)	8	soluble	YPO3928	115349537	argE	acetylornithine deacetylase [Yersinia pe...	389	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3PFO	26%	Yersinia pestis

IDP05133 (show subtarget assignments)	1	cloned	CD0264	126697836	flhF	flagellar biosynthesis regulator FlhF [C...	338	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J37	26%	Clostridium difficile	Protein fate: Protein and peptide secretion and trafficking

IDP91203 (show subtarget assignments)	8	cloned	BLD_0429	189439292	aroE	Shikimate 5-dehydrogenase [Bifidobacteri...	323	potential drug target / Shikimate pathway enzyme	Community Requests	1WXD	26%	Bifidobacterium longum

IDP02812 (show subtarget assignments)	1	cloned	FTT1484c	56708523	aceF	dihydrolipoamide acetyltransferase [Fran...	631	Conserved; Drug target functions	Phase 3: June 2008	3DUF	26%	Francisella tularensis	Energy metabolism	Pyruvate dehydrogenase

IDP01451 (show subtarget assignments)	1	soluble	VC2305	15642303		outer membrane protein OmpK	296	Conserved Gene / Pathway	Phase 2: March 2008	1TLW	26%	Vibrio cholerae	Transport and binding proteins	Nucleosides, purines and pyrimidines

IDP04267 (show subtarget assignments)	1	cloned	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01036 (show subtarget assignments)	1	purified	STM2897	16766203	invE	invasion protein	372	Conserved Gene / Pathway	Phase 2: March 2008	2VJ5	26.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP01517 (show subtarget assignments)	1	expressed	VC1254	15641267		iron-sulfur cluster-binding protein, put...	92	Conserved Gene / Pathway	Phase 2: March 2008	1AWD	26.1%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01020 (show subtarget assignments)	1	expressed	STM2110	16765440	wcaF	putative colanic acid biosynthesis acety...	184	Essential Gene	Phase 2: March 2008	3SRT	26.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00214 (show subtarget assignments)	1	expressed	YPO2252	16122476	-	putative toxin transport protein	712	Virulence	Phase 1: October 2007	2YL4	26.1%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01990 (show subtarget assignments)	0	work_stopped	Cj1435c	15792753		hypothetical protein Cj1435c [Campylobac...	211	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3FVV	26.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90758 (show subtarget assignments)	8	cloned	VC1149	15641162		glutamate decarboxylase, putative [Vibri...	548	Predicted Essential	Community Requests	2OKJ	26.1%	Vibrio cholerae

IDP00778 (show subtarget assignments)	1	cloned	SACOL0668	57284264		hydrolase, alpha/beta hydrolase fold fam...	266	Drug Target Function	Phase 2: March 2008	1VA4	26.1%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP02597 (show subtarget assignments)	1	expressed	YPO3472	16123618		putative sugar binding protein [Yersinia...	437	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1EU8	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90115 (show subtarget assignments)	8	soluble	MPXV_ZAI1979_005_024	68449098		kelch-like protein [Monkeypox virus]	176	similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L	Community Requests	2XN4	26.1%	Monkeypox virus

IDP00417 (show subtarget assignments)	1	cloned	YPO2604	16122817	pbpA	penicillin-binding protein 2	631	Drug Target Function	Phase 2: March 2008	3OC2	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00406 (show subtarget assignments)	1	cloned	YPO3410	16123559		hypothetical protein YPO3410	115	Virulence Associated Factor	Phase 2: March 2008	3UTK	26.1%	Yersinia pestis	Cell envelope	Other

IDP04470 (show subtarget assignments)	1	cloned	YPO2306	218929398		putative amino acid antiporter [Yersinia...	463	putative drug target function;	Phase 4: April 2009	3HQK	26.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP05698 (show subtarget assignments)	1	cloned	lmo2186	16804225	-	hypothetical protein lmo2186 [Listeria m...	207	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O6P	26.1%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP92004 (show subtarget assignments)	8	selected	SpneCM_010100007049	298255341		sortase, SrtB family protein [Streptococ...	332	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1RZ2	26.2%	Streptococcus pneumoniae

IDP91498 (show subtarget assignments)	8	expressed	VP1675	28898449		translocation protein in type III secret...	351	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2JLH	26.2%	Vibrio parahaemolyticus

IDP01239 (show subtarget assignments)	1	cloned	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02470 (show subtarget assignments)	1	purified	lmo0865	16802906		hypothetical protein lmo0865 [Listeria m...	557	Predicted involvement in glycosyl group metabolism; DNA binding Motifs	Phase 3: June 2008	1TUO	26.2%	Listeria monocytogenes	Energy metabolism	Sugars

IDP04639 (show subtarget assignments)	1	purified	FTT0556c	56707686	oxyR	oxidative stress transcriptional regulat...	289	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2H98	26.2%	Francisella tularensis	Regulatory functions	DNA interactions

IDP01208 (show subtarget assignments)	1	expressed	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90812 (show subtarget assignments)	8	soluble	YPO3117	16123282	hemH	ferrochelatase [Yersinia pestis CO92]	320	Predicted Essential	Community Requests	2QD2	26.2%	Yersinia pestis

IDP04070 (show subtarget assignments)	1	cloned	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP01132 (show subtarget assignments)	1	soluble	BA_4703	30259197	loN2	ATP-dependent protease LA	557	Drug Target Function	Phase 2: March 2008	3K1J	26.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05156 (show subtarget assignments)	1	expressed	BA_1093	30254823		putative S-layer protein [Bacillus anthr...	344	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	26.2%	Bacillus anthracis	Cell envelope: Surface structures

IDP02472 (show subtarget assignments)	1	purified	YPO3785	16123919		hypothetical protein YPO3785 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1YWF	26.2%	Yersinia pestis	Energy metabolism	Sugars

IDP91987 (show subtarget assignments)	8	selected	SpneCM_010100008765	298255669		ABC transporter substrate-binding protei...	335	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3IX1	26.3%	Streptococcus pneumoniae

IDP04730 (show subtarget assignments)	1	cloned	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP01503 (show subtarget assignments)	1	soluble	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP04506 (show subtarget assignments)	1	cloned	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP02057 (show subtarget assignments)	1	soluble	Cj1311	15792634	neuA2	acylneuraminate cytidylyltransferase [Ca...	232	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1QWJ	26.3%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04537 (show subtarget assignments)	8	selected	CAC05780	12329049	virF	VirF, member of the AraC family of trans...	262	Shigella effector protein	Community Requests	3GBG	26.3%	Shigella flexneri

IDP01708 (show subtarget assignments)	1	expressed	Cj0241c	15791613		putative iron-binding protein [Campyloba...	133	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2AVK	26.3%	Campylobacter jejuni	Cellular processes	Other

IDP01144 (show subtarget assignments)	1	purified	BA_5153	30259639		phosphoglucomutase/phosphomannomutase fa...	574	Drug Target Function	Phase 2: March 2008	2FUV	26.3%	Bacillus anthracis	Energy metabolism	Sugars

IDP02335 (show subtarget assignments)	1	expressed	GBAA2583	47527873		hypothetical protein GBAA2583 [Bacillus ...	563	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3SKS	26.3%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02399 (show subtarget assignments)	1	cloned	GBAA2559	47527848		D-alanyl-D-alanine carboxypeptidase fami...	338	Drug target motif; Drug target functions	Phase 3: June 2008	1XP4	26.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05595 (show subtarget assignments)	1	cloned	BA_3346	30257889		putative 6-aminohexanoate-dimer hydrolas...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WYB	26.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP02426 (show subtarget assignments)	1	cloned	CBU_1952	29542507		ABC transporter, ATP-binding protein [Co...	532	Conserved; Drug target functions	Phase 3: June 2008	2IW3	26.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04140 (show subtarget assignments)	1	cloned	YPO3116	115348760	ascD	cdp-6-deoxy-delta-3,4-glucoseen reductas...	329	virulence factor; putative drug target function;	Phase 4: April 2009	1KRH	26.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01628 (show subtarget assignments)	1	cloned	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	Phase 3: June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP05631 (show subtarget assignments)	1	soluble	CD1979	126699588		ABC transporter, substrate-binding prote...	337	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	26.4%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP01224 (show subtarget assignments)	1	cloned	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02210 (show subtarget assignments)	1	cloned	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP05050 (show subtarget assignments)	1	purified	BA_5330	30259806		iron compound ABC transporter, iron comp...	333	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GFV	26.4%	Bacillus anthracis	Transport and binding proteins: Cations and iron carrying compounds

IDP04110 (show subtarget assignments)	1	expressed	YPO2440	218929529	yfeB	ATP-binding transport protein [Yersinia ...	296	virulence factor; conserved gene;	Phase 4: April 2009	3GFO	26.4%	Yersinia pestis	Unknown function	General

IDP05444 (show subtarget assignments)	1	soluble	lmo0768	16802810	-	hypothetical protein lmo0768 [Listeria m...	417	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	26.4%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP91267
(show subtarget assignments)

8

selected

NT05BA2321

49179114

protein export protein prsA [Bacillus an...

283

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3RFW

25.4%

Bacillus anthracis

Protein fate: Protein folding and stabilization

IDP91940
(show subtarget assignments)

8

selected

SpneCM_010100006879

298255307

ABC transporter, ATP-binding protein [St...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

25.4%

Streptococcus pneumoniae

IDP05268
(show subtarget assignments)

1

cloned

lmo0366

16802411

-

hypothetical protein lmo0366 [Listeria m...

386

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3AT7

25.4%

Listeria monocytogenes

Cell envelope: Other

IDP91090
(show subtarget assignments)

8

cloned

aq_1546

15606685

kpsF

polysialic acid capsule expression prote...

322

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

25.5%

Aquifex aeolicus

IDP01215
(show subtarget assignments)

1

expressed

BA_3506

30258044

penicillin-binding protein, putative

345

Drug Target Function

Phase 2: March 2008

2QMI

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05264
(show subtarget assignments)

1

cloned

CD3257

126700876

putative polysaccharide deacetylase [Clo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1W17

25.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00860
(show subtarget assignments)

1

cloned

STM1910

16765252

putative penicillin-binding protein

623

Drug Target Function

Phase 2: March 2008

3PBN

25.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90242
(show subtarget assignments)

8

expressed

SA1814

15927582

succinyl-diaminopimelate desuccinylase [...

407

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3TX8

25.5%

Staphylococcus aureus

IDP04253
(show subtarget assignments)

1

purified

CPF_1800

110800480

prs

phosphoribosylpyrophosphate synthetase [...

364

conserved gene; putative drug target function;

Phase 4: April 2009

2C4K

25.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91959
(show subtarget assignments)

8

selected

SpneCM_010100000757

298254130

thioredoxin family protein [Streptococcu...

188

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3GL3

25.5%

Streptococcus pneumoniae

IDP01251
(show subtarget assignments)

1

cloned

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01900
(show subtarget assignments)

1

purified

STM0570

16763947

apeE

outer membrane esterase [Salmonella typh...

656

Drug target functions

Phase 3: June 2008

3KVN

25.5%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP90353
(show subtarget assignments)

8

expressed

CT198

15604918

oppA_3

oligopeptide binding protein [Chlamydia ...

518

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1UIU

25.5%

Chlamydia trachomatis

IDP00233
(show subtarget assignments)

1

cloned

YPO3676

16123819

-

putative phage-related protein

133

Virulence

Phase 1: October 2007

2VO9

25.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00532
(show subtarget assignments)

1

soluble

YPO2390

16122613

cfa

cyclopropane fatty acyl phospholipid syn...

383

Virulence Associated Factor

Phase 2: March 2008

1TPY

25.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02266
(show subtarget assignments)

1

purified

Cj0043

15791442

flgE

flagellar hook protein [Campylobacter je...

545

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

3A69

25.6%

Campylobacter jejuni

Cell envelope

Surface structures

IDP91962
(show subtarget assignments)

8

selected

SpneCM_010100007760

298255480

amino acid ABC transporter, amino acid-b...

266

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2YLN

25.6%

Streptococcus pneumoniae

IDP02388
(show subtarget assignments)

1

soluble

YPO1407

16121687

hypothetical protein YPO1407 [Yersinia p...

618

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1A9U

25.6%

Yersinia pestis

Cell envelope

Other

IDP02045
(show subtarget assignments)

1

cloned

FTT0749c

56707864

hypothetical protein FTT0749c [Francisel...

328

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AIM

25.6%

Francisella tularensis

Central intermediary metabolism

Other

IDP01799
(show subtarget assignments)

1

soluble

GBAA1127

47526398

S-layer protein, putative [Bacillus anth...

223

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.6%

Bacillus anthracis

Cell envelope

Surface structures

IDP90693
(show subtarget assignments)

8

purified

Cj1599

15792904

hisB

imidazole glycerol-phosphate dehydratase...

352

Predicted Essential

Community Requests

1RHY

25.6%

Campylobacter jejuni

IDP00674
(show subtarget assignments)

1

crystallized

SACOL1453

57286104

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

25.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02404
(show subtarget assignments)

1

cloned

GBAA2730

47528021

neutral protease [Bacillus anthracis str...

567

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

25.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05489
(show subtarget assignments)

1

cloned

CD0106

126697677

cwlD

germination-specific N-acetylmuramoyl-L-...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JWQ

25.6%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP01783
(show subtarget assignments)

1

expressed

FTT0824

56707935

arsC1

arsenate reductase [Francisella tularens...

117

Drug Target

Phase 3: June 2008

3GKX

25.6%

Francisella tularensis

Unknown function

General

IDP01903
(show subtarget assignments)

1

purified

STM0750

16764120

ybgF

hypothetical protein STM0750 [Salmonella...

262

Conserved; Drug target functions

Phase 3: June 2008

2WZ7

25.6%

Salmonella enterica

Unknown function

General

IDP02419
(show subtarget assignments)

1

purified

FTT1447c

56708489

manB

phosphomannomutase [Francisella tularens...

494

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2F7L

25.7%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00972
(show subtarget assignments)

1

expressed

STM1743

16765087

oppD

oligopeptide transporter ATP-binding com...

335

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

25.7%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP91910
(show subtarget assignments)

8

selected

SpneCM_010100003565

298254678

surface protein PspC, partial [Streptoco...

187

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2GRX

25.7%

Streptococcus pneumoniae

IDP01160
(show subtarget assignments)

1

expressed

BA_4774

30259261

bacitracin ABC transporter, ATP-binding ...

307

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

25.7%

Bacillus anthracis

Transport and binding proteins

Other

IDP91528
(show subtarget assignments)

8

purified

lpg1841

52629179

com1

27 kDa outer membrane protein [Legionell...

261

virulence/pathogenesis / Lpg1841 is most closely related to the major antigen of Coxiella burnetti, and o...

Community Requests

3GYK

25.7%

Legionella pneumophila

IDP02130
(show subtarget assignments)

1

cloned

Cj1416c

15792734

putative sugar nucleotidyltransferase [C...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

25.7%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01890
(show subtarget assignments)

1

cloned

Cj0063c

15791455

ATPase, ParA family [Campylobacter jejun...

288

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1HYQ

25.7%

Campylobacter jejuni

Cell envelope

Other

IDP91988
(show subtarget assignments)

8

selected

SpneCM_010100007640

298255458

phosphate-binding protein PstS 1 (PBP 1)...

292

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1TWY

25.7%

Streptococcus pneumoniae

IDP90642
(show subtarget assignments)

8

purified

Cj0585

15791945

folP

dihydropteroate synthase [Campylobacter ...

380

Predicted Essential

Community Requests

1AJ0

25.8%

Campylobacter jejuni

IDP02683
(show subtarget assignments)

1

cloned

GBAA2008

47527306

ribosome-associated GTPase [Bacillus ant...

364

Conserved; Essential;

Phase 3: June 2008

1T9H

25.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP05691
(show subtarget assignments)

1

cloned

lmo1800

16803840

-

hypothetical protein lmo1800 [Listeria m...

298

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YWF

25.8%

Listeria monocytogenes

Energy metabolism: Sugars

IDP05525
(show subtarget assignments)

1

soluble

CD2550

126700167

putative sugar transporter, substrate-bi...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

25.8%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP01370
(show subtarget assignments)

1

soluble

VC0247

15640277

lipopolysaccharide/O-antigen transport p...

271

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

25.8%

Vibrio cholerae

Transport and binding proteins

Other

IDP05327
(show subtarget assignments)

1

cloned

lmo1504

16803544

alaS

alanyl-tRNA synthetase [Listeria monocyt...

879

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RIQ

25.8%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP91544
(show subtarget assignments)

8

selected

BAE54319

83627318

ereB

erythromycin esterase type II [Escherich...

419

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2QGM

25.8%

Escherichia coli

IDP02794
(show subtarget assignments)

1

purified

FTT0477c

56707619

birA

transcription repressor BirA [Francisell...

260

Conserved; Drug target functions

Phase 3: June 2008

1BIA

25.8%

Francisella tularensis

Protein fate

Protein modification and repair

IDP04133
(show subtarget assignments)

1

cloned

CPF_1195

110798868

hpkA

sensor histidine kinase [Clostridium per...

287

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

25.8%

Clostridium perfringens

Regulatory functions

Other

IDP91342
(show subtarget assignments)

8

expressed

VV2_0079

27366538

DNA repair exonuclease [Vibrio vulnificu...

377

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3QG5

25.8%

Vibrio vulnificus

IDP05345
(show subtarget assignments)

1

soluble

Z3383

12516442

pbpG

penicillin-binding protein 7 [Escherichi...

313

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1XP4

25.9%

Escherichia coli

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00483
(show subtarget assignments)

1

expressed

YPO1316

16121598

putative iron/ascorbate oxidoreductase f...

355

Virulence Associated Factor

Phase 2: March 2008

3OOX

25.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP05710
(show subtarget assignments)

1

cloned

SACOL1673

57650500

alaS

alanyl-tRNA synthetase [Staphylococcus a...

876

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RIQ

25.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05357
(show subtarget assignments)

1

soluble

BA_0382

30253917

putative ABC transporter, substrate-bind...

332

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

25.9%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP91512
(show subtarget assignments)

8

cloned

VV2_0404

27366843

cytolysin [Vibrio vulnificus CMCP6]

468

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XEZ

25.9%

Vibrio vulnificus

IDP02245
(show subtarget assignments)

1

cloned

GBAA1751

47527043

asnO-2

asparagine synthetase, glutamine-hydroly...

607

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CT9

25.9%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP90247
(show subtarget assignments)

8

soluble

YPO3928

115349537

argE

acetylornithine deacetylase [Yersinia pe...

389

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3PFO

26%

Yersinia pestis

IDP05133
(show subtarget assignments)

1

cloned

CD0264

126697836

flhF

flagellar biosynthesis regulator FlhF [C...

338

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J37

26%

Clostridium difficile

Protein fate: Protein and peptide secretion and trafficking

IDP91203
(show subtarget assignments)

8

cloned

BLD_0429

189439292

aroE

Shikimate 5-dehydrogenase [Bifidobacteri...

323

potential drug target / Shikimate pathway enzyme

Community Requests

1WXD

26%

Bifidobacterium longum

IDP02812
(show subtarget assignments)

1

cloned

FTT1484c

56708523

aceF

dihydrolipoamide acetyltransferase [Fran...

631

Conserved; Drug target functions

Phase 3: June 2008

3DUF

26%

Francisella tularensis

Energy metabolism

Pyruvate dehydrogenase

IDP01451
(show subtarget assignments)

1

soluble

VC2305

15642303

outer membrane protein OmpK

296

Conserved Gene / Pathway

Phase 2: March 2008

1TLW

26%

Vibrio cholerae

Transport and binding proteins

Nucleosides, purines and pyrimidines

IDP04267
(show subtarget assignments)

1

cloned

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01036
(show subtarget assignments)

1

purified

STM2897

16766203

invE

invasion protein

372

Conserved Gene / Pathway

Phase 2: March 2008

2VJ5

26.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP01517
(show subtarget assignments)

1

expressed

VC1254

15641267

iron-sulfur cluster-binding protein, put...

92

Conserved Gene / Pathway

Phase 2: March 2008

1AWD

26.1%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01020
(show subtarget assignments)

1

expressed

STM2110

16765440

wcaF

putative colanic acid biosynthesis acety...

184

Essential Gene

Phase 2: March 2008

3SRT

26.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00214
(show subtarget assignments)

1

expressed

YPO2252

16122476

-

putative toxin transport protein

712

Virulence

Phase 1: October 2007

2YL4

26.1%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01990
(show subtarget assignments)

0

work_stopped

Cj1435c

15792753

hypothetical protein Cj1435c [Campylobac...

211

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3FVV

26.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90758
(show subtarget assignments)

8

cloned

VC1149

15641162

glutamate decarboxylase, putative [Vibri...

548

Predicted Essential

Community Requests

2OKJ

26.1%

Vibrio cholerae

IDP00778
(show subtarget assignments)

1

cloned

SACOL0668

57284264

hydrolase, alpha/beta hydrolase fold fam...

266

Drug Target Function

Phase 2: March 2008

1VA4

26.1%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP02597
(show subtarget assignments)

1

expressed

YPO3472

16123618

putative sugar binding protein [Yersinia...

437

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1EU8

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90115
(show subtarget assignments)

8

soluble

MPXV_ZAI1979_005_024

68449098

kelch-like protein [Monkeypox virus]

176

similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L

Community Requests

2XN4

26.1%

Monkeypox virus

IDP00417
(show subtarget assignments)

1

cloned

YPO2604

16122817

pbpA

penicillin-binding protein 2

631

Drug Target Function

Phase 2: March 2008

3OC2

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00406
(show subtarget assignments)

1

cloned

YPO3410

16123559

hypothetical protein YPO3410

115

Virulence Associated Factor

Phase 2: March 2008

3UTK

26.1%

Yersinia pestis

Cell envelope

Other

IDP04470
(show subtarget assignments)

1

cloned

YPO2306

218929398

putative amino acid antiporter [Yersinia...

463

putative drug target function;

Phase 4: April 2009

3HQK

26.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP05698
(show subtarget assignments)

1

cloned

lmo2186

16804225

-

hypothetical protein lmo2186 [Listeria m...

207

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O6P

26.1%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP92004
(show subtarget assignments)

8

selected

SpneCM_010100007049

298255341

sortase, SrtB family protein [Streptococ...

332

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1RZ2

26.2%

Streptococcus pneumoniae

IDP91498
(show subtarget assignments)

8

expressed

VP1675

28898449

translocation protein in type III secret...

351

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2JLH

26.2%

Vibrio parahaemolyticus

IDP01239
(show subtarget assignments)

1

cloned

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02470
(show subtarget assignments)

1

purified

lmo0865

16802906

hypothetical protein lmo0865 [Listeria m...

557

Predicted involvement in glycosyl group metabolism; DNA binding Motifs

Phase 3: June 2008

1TUO

26.2%

Listeria monocytogenes

Energy metabolism

Sugars

IDP04639
(show subtarget assignments)

1

purified

FTT0556c

56707686

oxyR

oxidative stress transcriptional regulat...

289

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2H98

26.2%

Francisella tularensis

Regulatory functions

DNA interactions

IDP01208
(show subtarget assignments)

1

expressed

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90812
(show subtarget assignments)

8

soluble

YPO3117

16123282

hemH

ferrochelatase [Yersinia pestis CO92]

320

Predicted Essential

Community Requests

2QD2

26.2%

Yersinia pestis

IDP04070
(show subtarget assignments)

1

cloned

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP01132
(show subtarget assignments)

1

soluble

BA_4703

30259197

loN2

ATP-dependent protease LA

557

Drug Target Function

Phase 2: March 2008

3K1J

26.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05156
(show subtarget assignments)

1

expressed

BA_1093

30254823

putative S-layer protein [Bacillus anthr...

344

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

26.2%

Bacillus anthracis

Cell envelope: Surface structures

IDP02472
(show subtarget assignments)

1

purified

YPO3785

16123919

hypothetical protein YPO3785 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1YWF

26.2%

Yersinia pestis

Energy metabolism

Sugars

IDP91987
(show subtarget assignments)

8

selected

SpneCM_010100008765

298255669

ABC transporter substrate-binding protei...

335

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3IX1

26.3%

Streptococcus pneumoniae

IDP04730
(show subtarget assignments)

1

cloned

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

IDP01503
(show subtarget assignments)

1

soluble

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP04506
(show subtarget assignments)

1

cloned

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP02057
(show subtarget assignments)

1

soluble

Cj1311

15792634

neuA2

acylneuraminate cytidylyltransferase [Ca...

232

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1QWJ

26.3%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04537
(show subtarget assignments)

8

selected

CAC05780

12329049

virF

VirF, member of the AraC family of trans...

262

Shigella effector protein

Community Requests

3GBG

26.3%

Shigella flexneri

IDP01708
(show subtarget assignments)

1

expressed

Cj0241c

15791613

putative iron-binding protein [Campyloba...

133

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2AVK

26.3%

Campylobacter jejuni

Cellular processes

Other

IDP01144
(show subtarget assignments)

1

purified

BA_5153

30259639

phosphoglucomutase/phosphomannomutase fa...

574

Drug Target Function

Phase 2: March 2008

2FUV

26.3%

Bacillus anthracis

Energy metabolism

Sugars

IDP02335
(show subtarget assignments)

1

expressed

GBAA2583

47527873

hypothetical protein GBAA2583 [Bacillus ...

563

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3SKS

26.3%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02399
(show subtarget assignments)

1

cloned

GBAA2559

47527848

D-alanyl-D-alanine carboxypeptidase fami...

338

Drug target motif; Drug target functions

Phase 3: June 2008

1XP4

26.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05595
(show subtarget assignments)

1

cloned

BA_3346

30257889

putative 6-aminohexanoate-dimer hydrolas...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WYB

26.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP02426
(show subtarget assignments)

1

cloned

CBU_1952

29542507

ABC transporter, ATP-binding protein [Co...

532

Conserved; Drug target functions

Phase 3: June 2008

2IW3

26.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04140
(show subtarget assignments)

1

cloned

YPO3116

115348760

ascD

cdp-6-deoxy-delta-3,4-glucoseen reductas...

329

virulence factor; putative drug target function;

Phase 4: April 2009

1KRH

26.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01628
(show subtarget assignments)

1

cloned

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

Phase 3: June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP05631
(show subtarget assignments)

1

soluble

CD1979

126699588

ABC transporter, substrate-binding prote...

337

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

26.4%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP01224
(show subtarget assignments)

1

cloned

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02210
(show subtarget assignments)

1

cloned

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP05050
(show subtarget assignments)

1

purified

BA_5330

30259806

iron compound ABC transporter, iron comp...

333

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GFV

26.4%

Bacillus anthracis

Transport and binding proteins: Cations and iron carrying compounds

IDP04110
(show subtarget assignments)

1

expressed

YPO2440

218929529

yfeB

ATP-binding transport protein [Yersinia ...

296

virulence factor; conserved gene;

Phase 4: April 2009

3GFO

26.4%

Yersinia pestis

Unknown function

General

IDP05444
(show subtarget assignments)

1

soluble

lmo0768

16802810

-

hypothetical protein lmo0768 [Listeria m...

417

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

26.4%

Listeria monocytogenes

Unclassified: Role category not yet assigned