Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01000 (show subtarget assignments)	1	expressed	STM2389	16765716	fadI	3-ketoacyl-CoA thiolase	436	Conserved Gene / Pathway	Phase 2: March 2008	1ULQ	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01001 (show subtarget assignments)	1	soluble	STM2405	16765731		indolepyruvate decarboxylase	550	Conserved Gene / Pathway	Phase 2: March 2008	1OVM	66.7%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01002 (show subtarget assignments)	1	in_pdb 3ERP	STM2406	16765732		putative oxidoreductase	332	Essential Gene	Phase 2: March 2008	3ERP	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP01003 (show subtarget assignments)	1	cloned	STM2479	16765799	aegA	putative oxidoreductase Fe-S binding sub...	653	Conserved Gene / Pathway	Phase 2: March 2008	2VDC	29.2%	Salmonella enterica	Central intermediary metabolism	Other

IDP01004 (show subtarget assignments)	1	in_pdb 3G0S	STM2489	16765809	dapA	dihydrodipicolinate synthase	292	Conserved Gene / Pathway	Phase 2: March 2008	3G0S	100%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01005 (show subtarget assignments)	1	purified	STM2511	16765831	guaB	inositol-5-monophosphate dehydrogenase	488	Conserved Gene / Pathway	Phase 2: March 2008	3TSB	55.9%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01006 (show subtarget assignments)	1	soluble	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01007 (show subtarget assignments)	1	cloned	STM2531	16765851	pbpC	penicillin-binding protein 1C	771	Drug Target Function	Phase 2: March 2008	2OLU	21.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01008 (show subtarget assignments)	1	soluble	STM2533	16765853	sseA	3-mercaptopyruvate sulfurtransferase	280	Conserved Gene / Pathway	Phase 2: March 2008	1URH	79.6%	Salmonella enterica	Cellular processes	Detoxification

IDP01009 (show subtarget assignments)	1	cloned	STM2535	16765855	sseB	enhanced serine sensitivity protein	261	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01010 (show subtarget assignments)	1	purified	STM2539	16765859	hscA	chaperone protein HscA	616	Conserved Gene / Pathway	Phase 2: March 2008	2KHO	40.9%	Salmonella enterica	Protein fate	Protein folding and stabilization

IDP01011 (show subtarget assignments)	1	in_pdb 3GBX	STM2555	16765875	glyA	serine hydroxymethyltransferase	417	Conserved Gene / Pathway	Phase 2: March 2008	3GBX	100%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP01012 (show subtarget assignments)	1	purified	STM2578	16765898	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Conserved Gene / Pathway	Phase 2: March 2008	1M5W	93.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01013 (show subtarget assignments)	1	purified	STM2670	16765985	aroF	phospho-2-dehydro-3-deoxyheptonate aldol...	356	Conserved Gene / Pathway	Phase 2: March 2008	1GG1	51.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP01014 (show subtarget assignments)	1	purified	STM2780	16766091	pipB2	secreted effector protein	350	Virulence Associated Factor	Phase 2: March 2008	2LEZ	41.4%	Salmonella enterica	Unknown function	General

IDP01015 (show subtarget assignments)	0	work_stopped	STM2791	16766102	gabD	succinate-semialdehyde dehydrogenase I	482	Conserved Gene / Pathway	Phase 2: March 2008	3JZ4	90%	Salmonella enterica	Central intermediary metabolism	Other

IDP01016 (show subtarget assignments)	1	cloned	STM2792	16766103	gabT	4-aminobutyrate aminotransferase	427	Conserved Gene / Pathway	Phase 2: March 2008	1SF2	88.3%	Salmonella enterica	Central intermediary metabolism	Other

IDP01017 (show subtarget assignments)	1	expressed	STM2854	16766160	hypA	hydrogenase nickel incorporation protein...	118	Conserved Gene / Pathway	Phase 2: March 2008	3A43	24.6%	Salmonella enterica	Protein fate	Protein modification and repair

IDP01018 (show subtarget assignments)	1	expressed	STM2894	16766200	invC	ATP synthase SpaL	431	Conserved Gene / Pathway	Phase 2: March 2008	2OBL	38.7%	Salmonella enterica	Transport and binding proteins	Other

IDP01019 (show subtarget assignments)	0	work_stopped	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01020 (show subtarget assignments)	1	expressed	STM2110	16765440	wcaF	putative colanic acid biosynthesis acety...	184	Essential Gene	Phase 2: March 2008	3SRT	26.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP01021 (show subtarget assignments)	1	cloned	STM0044	16763434	yaaY	putative cytoplasmic protein	71	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01022 (show subtarget assignments)	1	purified	STM0048	16763438	slpA	FKBP-type peptidyl-prolyl cis-trans isom...	149	Conserved Gene / Pathway	Phase 2: March 2008	3PR9	29.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01023 (show subtarget assignments)	1	purified	STM1051	16764411	sseI	secreted effector protein [Phage Gifsy-2...	322	Virulence Associated Factor	Phase 2: March 2008	3CXB	15.8%	Salmonella enterica	Unknown function	General

IDP01024 (show subtarget assignments)	1	purified	STM1172	16764528	flgM	anti-sigma28 factor FlgM	97	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Cell envelope	Surface structures

IDP01025 (show subtarget assignments)	1	cloned	STM1196	16764551	acpP	acyl carrier protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1L0H	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01026 (show subtarget assignments)	1	cloned	STM1267	16764618		putative cytoplasmic protein	82	Conserved Gene / Pathway	Phase 2: March 2008	2OXL	32.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01027 (show subtarget assignments)	1	purified	STM1346	16764697	ydiE	hypothetical protein STM1346	63	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01028 (show subtarget assignments)	1	purified	STM1707	16765051	pyrF	orotidine 5'-phosphate decarboxylase	245	Essential Gene	Phase 2: March 2008	1EIX	88.2%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01029 (show subtarget assignments)	0	work_stopped	STM1916	16765258	cheY	chemotaxis regulator transmitting signal...	129	Conserved Gene / Pathway	Phase 2: March 2008	2FKA	100%	Salmonella enterica	Cellular processes	Other

IDP01030 (show subtarget assignments)	1	cloned	STM2107	16765437	wcaH	GDP-mannose mannosyl hydrolase	167	Conserved Gene / Pathway	Phase 2: March 2008	2I8T	65.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01031 (show subtarget assignments)	0	work_stopped	STM3497	16766785	yrfH	ribosome-associated heat shock protein H...	133	Conserved Gene / Pathway	Phase 2: March 2008	1DM9	95.5%	Salmonella enterica	Protein synthesis	Other

IDP01032 (show subtarget assignments)	1	soluble	STM3507	16766795	yhgG	putative cytoplasmic protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1XN7	89.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01033 (show subtarget assignments)	1	soluble	STM3815	16767100	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01034 (show subtarget assignments)	0	work_stopped	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01035 (show subtarget assignments)	0	work_stopped	STM4146	16767400	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01036 (show subtarget assignments)	1	purified	STM2897	16766203	invE	invasion protein	372	Conserved Gene / Pathway	Phase 2: March 2008	2VJ5	26.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP01037 (show subtarget assignments)	0	work_stopped	STM2927	16766233	surE	stationary phase survival protein SurE	253	potential drug target / Conserved Gene / Pathway	Phase 2: March 2008	2V4N	100%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP01038 (show subtarget assignments)	1	in_pdb 3GHZ	STM2929	16766235	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	159	Drug Target Function	Phase 2: March 2008	3GHZ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01039 (show subtarget assignments)	1	expressed	STM2934	16766240	cysN	sulfate adenylyltransferase subunit 1	479	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	52.4%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01040 (show subtarget assignments)	1	expressed	STM2935	16766241	cysD	sulfate adenylyltransferase subunit 2	302	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	75.2%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01041 (show subtarget assignments)	1	purified	STM2971	16766276	sdaB	L-serine dehydratase/L-threonine deamina...	455	Conserved Gene / Pathway	Phase 2: March 2008	2IQQ	16%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP01042 (show subtarget assignments)	1	purified	STM2973	16766278	fucO	L-1,2-propanediol oxidoreductase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	91.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP01043 (show subtarget assignments)	1	soluble	STM2985	16766289	ygdK	putative FeS center assembly protein	147	Conserved Gene / Pathway	Phase 2: March 2008	1NI7	86.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01044 (show subtarget assignments)	1	soluble	STM3070	16766371	epd	D-erythrose 4-phosphate dehydrogenase	348	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	91.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01045 (show subtarget assignments)	1	soluble	STM3114	16766415	speC	ornithine decarboxylase isozyme	711	Conserved Gene / Pathway	Phase 2: March 2008	1ORD	53.8%	Salmonella enterica	Central intermediary metabolism	Polyamine biosynthesis

IDP01046 (show subtarget assignments)	1	expressed	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP01047 (show subtarget assignments)	1	cloned	STM3152	16766452		putative methyl-accepting chemotaxis pro...	547	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	28%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01048 (show subtarget assignments)	1	in_pdb 3R3S	STM3157	16766457	yghA	oxidoreductase	294	Conserved Gene / Pathway	Phase 2: March 2008	3R3S	100%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01049 (show subtarget assignments)	1	purified	STM3183	16766483	icc	cyclic 3',5'-adenosine monophosphate pho...	275	Conserved Gene / Pathway	Phase 2: March 2008	2HY1	25.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP01050 (show subtarget assignments)	1	cloned	STM3201	16766501	glnE	bifunctional glutamine-synthetase adenyl...	947	Conserved Gene / Pathway	Phase 2: March 2008	3K7D	47.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP01051 (show subtarget assignments)	1	expressed	STM3219	16766518	fadH	2,4-dieonyl-CoA reductase	672	Drug Target Function	Phase 2: March 2008	1PS9	85.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01052 (show subtarget assignments)	1	expressed	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01053 (show subtarget assignments)	1	cloned	STM3330	16766625	gltB	glutamate synthase subunit alpha	1486	Conserved Gene / Pathway	Phase 2: March 2008	1EA0	45.2%	Salmonella enterica	Central intermediary metabolism	Other

IDP01054 (show subtarget assignments)	1	purified	STM3363	16766658	yhcO	putative cytoplasmic protein	90	Conserved Gene / Pathway	Phase 2: March 2008	2CX6	76.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01055 (show subtarget assignments)	1	crystallized	STM3371	16766666	maf	Maf-like protein	197	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	43.7%	Salmonella enterica	Cellular processes	Cell division

IDP01056 (show subtarget assignments)	1	in_pdb 3R3R	STM3399	16766688	yrdA	putative ferripyochelin-binding protein ...	184	Conserved Gene / Pathway	Phase 2: March 2008	3R3R	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP01057 (show subtarget assignments)	0	work_stopped	STM3445	16766734	tuf	elongation factor Tu	394	Conserved Gene / Pathway	Phase 2: March 2008	1D8T	99.5%	Salmonella enterica	Protein synthesis	Translation factors

IDP01058 (show subtarget assignments)	1	purified	STM3486	16766774	aroB	3-dehydroquinate synthase	362	Conserved Gene / Pathway	Phase 2: March 2008	3OKF	62.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP01059 (show subtarget assignments)	1	soluble	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01060 (show subtarget assignments)	1	crystallized	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01061 (show subtarget assignments)	1	purified	STM3591	16766877	uspA	universal stress protein A	144	Conserved Gene / Pathway	Phase 2: March 2008	1JMV	66.7%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP01062 (show subtarget assignments)	1	cloned	STM3626	16766913	dppF	dipeptide transporter ATP-binding subuni...	337	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.6%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01063 (show subtarget assignments)	1	soluble	STM3702	16766987	grxC	glutaredoxin 3	83	Conserved Gene / Pathway	Phase 2: March 2008	1FOV	86.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP01064 (show subtarget assignments)	1	cloned	STM3719	16767004	rfaB	UDP-D-galactose:(glucosyl)lipopolysaccha...	359	Essential Gene	Phase 2: March 2008	2JJM	13.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01065 (show subtarget assignments)	1	expressed	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01066 (show subtarget assignments)	1	expressed	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01067 (show subtarget assignments)	1	expressed	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP01068 (show subtarget assignments)	0	work_stopped	STM3920	16767195	wecB	UDP-N-acetyl glucosamine-2-epimerase	376	Drug Target Function	Phase 2: March 2008	1F6D	85.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01069 (show subtarget assignments)	1	soluble	STM3938	16767209	hemC	porphobilinogen deaminase	318	Conserved Gene / Pathway	Phase 2: March 2008	1AH5	87.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01070 (show subtarget assignments)	1	expressed	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP01071 (show subtarget assignments)	1	in_pdb 3GOA	STM3982	16767252	fadA	3-ketoacyl-CoA thiolase	387	Conserved Gene / Pathway	Phase 2: March 2008	3GOA	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01072 (show subtarget assignments)	1	cloned	STM4003	16767268	yihI	hypothetical protein STM4003	171	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01073 (show subtarget assignments)	1	soluble	STM4044	16767310		putative alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	42.6%	Salmonella enterica	Energy metabolism	Fermentation

IDP01074 (show subtarget assignments)	1	in_pdb 3FPK	STM4084	16767350	fpr	ferredoxin-NADP reductase	248	Conserved Gene / Pathway	Phase 2: March 2008	3FPK	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP01075 (show subtarget assignments)	1	cloned	STM4106	16767372	katG	hydroperoxidase	726	Essential Gene	Phase 2: March 2008	1MWV	64.3%	Salmonella enterica	Cellular processes	Detoxification

IDP01076 (show subtarget assignments)	8	expressed	STM4120	16767385	argE	acetylornithine deacetylase	383	Drug Target Function	Community Requests	3CT9	25.1%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01077 (show subtarget assignments)	0	work_stopped	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01078 (show subtarget assignments)	1	soluble	STM4137	16767396	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	342	Essential Gene	Phase 2: March 2008	1MBB	82.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01079 (show subtarget assignments)	0	work_stopped	STM4167	16767421	hemE	uroporphyrinogen decarboxylase	354	Essential Gene	Phase 2: March 2008	3CYV	96%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01080 (show subtarget assignments)	0	work_stopped	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01081 (show subtarget assignments)	1	soluble	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	3LQ7	24.8%	Salmonella enterica	Cellular processes	Detoxification

IDP01082 (show subtarget assignments)	1	expressed	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP01083 (show subtarget assignments)	1	in_pdb 3OPK	STM4324	16767573	cutA	divalent-cation tolerance protein CutA	115	Conserved Gene / Pathway	Phase 2: March 2008	3OPK	100%	Salmonella enterica	Cellular processes	Detoxification

IDP01084 (show subtarget assignments)	1	purified	STM4377	161353573	aidB	putative acyl-CoA dehydrogenase	546	Conserved Gene / Pathway	Phase 2: March 2008	3DJL	84.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01085 (show subtarget assignments)	1	purified	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP01086 (show subtarget assignments)	1	purified	STM4404	16767650	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphos...	246	Conserved Gene / Pathway	Phase 2: March 2008	3B8B	48.1%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01087 (show subtarget assignments)	1	cloned	STM4465	16767710		ornithine carbamoyltransferase	334	Conserved Gene / Pathway	Phase 2: March 2008	3UPD	75.7%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01088 (show subtarget assignments)	1	expressed	STM4512	16767756	iadA	isoaspartyl dipeptidase	390	Drug Target Function	Phase 2: March 2008	1ONX	81%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01089 (show subtarget assignments)	1	soluble	STM4533	16767777	tsr	methyl-accepting chemotaxis protein I	553	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	38.9%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01090 (show subtarget assignments)	0	work_stopped	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP01091 (show subtarget assignments)	1	purified	STM4578	16767819	serB	phosphoserine phosphatase	322	Conserved Gene / Pathway	Phase 2: March 2008	3N28	47.2%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP01100 (show subtarget assignments)	1	in_pdb 3K1S	BA_5442	30259910	celC-2	PTS system, cellobiose-specific IIA comp...	107	Conserved Gene / Pathway	Phase 2: March 2008	3K1S	99.1%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01101 (show subtarget assignments)	1	expressed	GBAA_pXO1_0119	47566439		hypothetical protein GBAA_pXO1_0119	82	Virulence Associated Factor	Phase 2: March 2008	2K78	34.1%	Bacillus anthracis

IDP01102 (show subtarget assignments)	1	soluble	BA_5424	49040749		Cold shock-like protein cspC	65	Essential Gene	Phase 2: March 2008	1C9O	74.2%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01103 (show subtarget assignments)	1	cloned	BA_1387	47605671		D-alanine--poly(phosphoribitol) ligase s...	79	Drug Target Function	Phase 2: March 2008	1DV5	45.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01104 (show subtarget assignments)	1	soluble	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01105 (show subtarget assignments)	1	soluble	BA_2788	67460529		ATP-dependent Clp protease proteolytic s...	193	Drug Target Function	Phase 2: March 2008	3TT7	67.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01106 (show subtarget assignments)	1	soluble	BA_1846	30256116	msrA-1	peptide methionine sulfoxide reductase	178	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	36%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP01107 (show subtarget assignments)	1	soluble	BA_2250	30256894		heat shock protein, Hsp20 family	153	Conserved Gene / Pathway	Phase 2: March 2008	3AAB	24.2%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01000
(show subtarget assignments)

1

expressed

STM2389

16765716

fadI

3-ketoacyl-CoA thiolase

436

Conserved Gene / Pathway

Phase 2: March 2008

1ULQ

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01001
(show subtarget assignments)

1

soluble

STM2405

16765731

indolepyruvate decarboxylase

550

Conserved Gene / Pathway

Phase 2: March 2008

1OVM

66.7%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01002
(show subtarget assignments)

1

in_pdb
3ERP

STM2406

16765732

putative oxidoreductase

332

Essential Gene

Phase 2: March 2008

3ERP

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP01003
(show subtarget assignments)

1

cloned

STM2479

16765799

aegA

putative oxidoreductase Fe-S binding sub...

653

Conserved Gene / Pathway

Phase 2: March 2008

2VDC

29.2%

Salmonella enterica

Central intermediary metabolism

Other

IDP01004
(show subtarget assignments)

1

in_pdb
3G0S

STM2489

16765809

dapA

dihydrodipicolinate synthase

292

Conserved Gene / Pathway

Phase 2: March 2008

3G0S

100%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01005
(show subtarget assignments)

1

purified

STM2511

16765831

guaB

inositol-5-monophosphate dehydrogenase

488

Conserved Gene / Pathway

Phase 2: March 2008

3TSB

55.9%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01006
(show subtarget assignments)

1

soluble

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01007
(show subtarget assignments)

1

cloned

STM2531

16765851

pbpC

penicillin-binding protein 1C

771

Drug Target Function

Phase 2: March 2008

2OLU

21.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01008
(show subtarget assignments)

1

soluble

STM2533

16765853

sseA

3-mercaptopyruvate sulfurtransferase

280

Conserved Gene / Pathway

Phase 2: March 2008

1URH

79.6%

Salmonella enterica

Cellular processes

Detoxification

IDP01009
(show subtarget assignments)

1

cloned

STM2535

16765855

sseB

enhanced serine sensitivity protein

261

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01010
(show subtarget assignments)

1

purified

STM2539

16765859

hscA

chaperone protein HscA

616

Conserved Gene / Pathway

Phase 2: March 2008

2KHO

40.9%

Salmonella enterica

Protein fate

Protein folding and stabilization

IDP01011
(show subtarget assignments)

1

in_pdb
3GBX

STM2555

16765875

glyA

serine hydroxymethyltransferase

417

Conserved Gene / Pathway

Phase 2: March 2008

3GBX

100%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP01012
(show subtarget assignments)

1

purified

STM2578

16765898

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Conserved Gene / Pathway

Phase 2: March 2008

1M5W

93.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01013
(show subtarget assignments)

1

purified

STM2670

16765985

aroF

phospho-2-dehydro-3-deoxyheptonate aldol...

356

Conserved Gene / Pathway

Phase 2: March 2008

1GG1

51.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP01014
(show subtarget assignments)

1

purified

STM2780

16766091

pipB2

secreted effector protein

350

Virulence Associated Factor

Phase 2: March 2008

2LEZ

41.4%

Salmonella enterica

Unknown function

General

IDP01015
(show subtarget assignments)

0

work_stopped

STM2791

16766102

gabD

succinate-semialdehyde dehydrogenase I

482

Conserved Gene / Pathway

Phase 2: March 2008

3JZ4

90%

Salmonella enterica

Central intermediary metabolism

Other

IDP01016
(show subtarget assignments)

1

cloned

STM2792

16766103

gabT

4-aminobutyrate aminotransferase

427

Conserved Gene / Pathway

Phase 2: March 2008

1SF2

88.3%

Salmonella enterica

Central intermediary metabolism

Other

IDP01017
(show subtarget assignments)

1

expressed

STM2854

16766160

hypA

hydrogenase nickel incorporation protein...

118

Conserved Gene / Pathway

Phase 2: March 2008

3A43

24.6%

Salmonella enterica

Protein fate

Protein modification and repair

IDP01018
(show subtarget assignments)

1

expressed

STM2894

16766200

invC

ATP synthase SpaL

431

Conserved Gene / Pathway

Phase 2: March 2008

2OBL

38.7%

Salmonella enterica

Transport and binding proteins

Other

IDP01019
(show subtarget assignments)

0

work_stopped

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01020
(show subtarget assignments)

1

expressed

STM2110

16765440

wcaF

putative colanic acid biosynthesis acety...

184

Essential Gene

Phase 2: March 2008

3SRT

26.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP01021
(show subtarget assignments)

1

cloned

STM0044

16763434

yaaY

putative cytoplasmic protein

71

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01022
(show subtarget assignments)

1

purified

STM0048

16763438

slpA

FKBP-type peptidyl-prolyl cis-trans isom...

149

Conserved Gene / Pathway

Phase 2: March 2008

3PR9

29.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01023
(show subtarget assignments)

1

purified

STM1051

16764411

sseI

secreted effector protein [Phage Gifsy-2...

322

Virulence Associated Factor

Phase 2: March 2008

3CXB

15.8%

Salmonella enterica

Unknown function

General

IDP01024
(show subtarget assignments)

1

purified

STM1172

16764528

flgM

anti-sigma28 factor FlgM

97

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Cell envelope

Surface structures

IDP01025
(show subtarget assignments)

1

cloned

STM1196

16764551

acpP

acyl carrier protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1L0H

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01026
(show subtarget assignments)

1

cloned

STM1267

16764618

putative cytoplasmic protein

82

Conserved Gene / Pathway

Phase 2: March 2008

2OXL

32.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01027
(show subtarget assignments)

1

purified

STM1346

16764697

ydiE

hypothetical protein STM1346

63

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01028
(show subtarget assignments)

1

purified

STM1707

16765051

pyrF

orotidine 5'-phosphate decarboxylase

245

Essential Gene

Phase 2: March 2008

1EIX

88.2%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01029
(show subtarget assignments)

0

work_stopped

STM1916

16765258

cheY

chemotaxis regulator transmitting signal...

129

Conserved Gene / Pathway

Phase 2: March 2008

2FKA

100%

Salmonella enterica

Cellular processes

Other

IDP01030
(show subtarget assignments)

1

cloned

STM2107

16765437

wcaH

GDP-mannose mannosyl hydrolase

167

Conserved Gene / Pathway

Phase 2: March 2008

2I8T

65.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01031
(show subtarget assignments)

0

work_stopped

STM3497

16766785

yrfH

ribosome-associated heat shock protein H...

133

Conserved Gene / Pathway

Phase 2: March 2008

1DM9

95.5%

Salmonella enterica

Protein synthesis

Other

IDP01032
(show subtarget assignments)

1

soluble

STM3507

16766795

yhgG

putative cytoplasmic protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1XN7

89.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01033
(show subtarget assignments)

1

soluble

STM3815

16767100

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01034
(show subtarget assignments)

0

work_stopped

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01035
(show subtarget assignments)

0

work_stopped

STM4146

16767400

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01036
(show subtarget assignments)

1

purified

STM2897

16766203

invE

invasion protein

372

Conserved Gene / Pathway

Phase 2: March 2008

2VJ5

26.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP01037
(show subtarget assignments)

0

work_stopped

STM2927

16766233

surE

stationary phase survival protein SurE

253

potential drug target / Conserved Gene / Pathway

Phase 2: March 2008

2V4N

100%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP01038
(show subtarget assignments)

1

in_pdb
3GHZ

STM2929

16766235

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

159

Drug Target Function

Phase 2: March 2008

3GHZ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01039
(show subtarget assignments)

1

expressed

STM2934

16766240

cysN

sulfate adenylyltransferase subunit 1

479

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

52.4%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01040
(show subtarget assignments)

1

expressed

STM2935

16766241

cysD

sulfate adenylyltransferase subunit 2

302

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

75.2%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01041
(show subtarget assignments)

1

purified

STM2971

16766276

sdaB

L-serine dehydratase/L-threonine deamina...

455

Conserved Gene / Pathway

Phase 2: March 2008

2IQQ

16%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP01042
(show subtarget assignments)

1

purified

STM2973

16766278

fucO

L-1,2-propanediol oxidoreductase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

91.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP01043
(show subtarget assignments)

1

soluble

STM2985

16766289

ygdK

putative FeS center assembly protein

147

Conserved Gene / Pathway

Phase 2: March 2008

1NI7

86.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01044
(show subtarget assignments)

1

soluble

STM3070

16766371

epd

D-erythrose 4-phosphate dehydrogenase

348

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

91.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01045
(show subtarget assignments)

1

soluble

STM3114

16766415

speC

ornithine decarboxylase isozyme

711

Conserved Gene / Pathway

Phase 2: March 2008

1ORD

53.8%

Salmonella enterica

Central intermediary metabolism

Polyamine biosynthesis

IDP01046
(show subtarget assignments)

1

expressed

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP01047
(show subtarget assignments)

1

cloned

STM3152

16766452

putative methyl-accepting chemotaxis pro...

547

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

28%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01048
(show subtarget assignments)

1

in_pdb
3R3S

STM3157

16766457

yghA

oxidoreductase

294

Conserved Gene / Pathway

Phase 2: March 2008

3R3S

100%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01049
(show subtarget assignments)

1

purified

STM3183

16766483

icc

cyclic 3',5'-adenosine monophosphate pho...

275

Conserved Gene / Pathway

Phase 2: March 2008

2HY1

25.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP01050
(show subtarget assignments)

1

cloned

STM3201

16766501

glnE

bifunctional glutamine-synthetase adenyl...

947

Conserved Gene / Pathway

Phase 2: March 2008

3K7D

47.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP01051
(show subtarget assignments)

1

expressed

STM3219

16766518

fadH

2,4-dieonyl-CoA reductase

672

Drug Target Function

Phase 2: March 2008

1PS9

85.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01052
(show subtarget assignments)

1

expressed

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01053
(show subtarget assignments)

1

cloned

STM3330

16766625

gltB

glutamate synthase subunit alpha

1486

Conserved Gene / Pathway

Phase 2: March 2008

1EA0

45.2%

Salmonella enterica

Central intermediary metabolism

Other

IDP01054
(show subtarget assignments)

1

purified

STM3363

16766658

yhcO

putative cytoplasmic protein

90

Conserved Gene / Pathway

Phase 2: March 2008

2CX6

76.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01055
(show subtarget assignments)

1

crystallized

STM3371

16766666

maf

Maf-like protein

197

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

43.7%

Salmonella enterica

Cellular processes

Cell division

IDP01056
(show subtarget assignments)

1

in_pdb
3R3R

STM3399

16766688

yrdA

putative ferripyochelin-binding protein ...

184

Conserved Gene / Pathway

Phase 2: March 2008

3R3R

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP01057
(show subtarget assignments)

0

work_stopped

STM3445

16766734

tuf

elongation factor Tu

394

Conserved Gene / Pathway

Phase 2: March 2008

1D8T

99.5%

Salmonella enterica

Protein synthesis

Translation factors

IDP01058
(show subtarget assignments)

1

purified

STM3486

16766774

aroB

3-dehydroquinate synthase

362

Conserved Gene / Pathway

Phase 2: March 2008

3OKF

62.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP01059
(show subtarget assignments)

1

soluble

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01060
(show subtarget assignments)

1

crystallized

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01061
(show subtarget assignments)

1

purified

STM3591

16766877

uspA

universal stress protein A

144

Conserved Gene / Pathway

Phase 2: March 2008

1JMV

66.7%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP01062
(show subtarget assignments)

1

cloned

STM3626

16766913

dppF

dipeptide transporter ATP-binding subuni...

337

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.6%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01063
(show subtarget assignments)

1

soluble

STM3702

16766987

grxC

glutaredoxin 3

83

Conserved Gene / Pathway

Phase 2: March 2008

1FOV

86.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP01064
(show subtarget assignments)

1

cloned

STM3719

16767004

rfaB

UDP-D-galactose:(glucosyl)lipopolysaccha...

359

Essential Gene

Phase 2: March 2008

2JJM

13.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01065
(show subtarget assignments)

1

expressed

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01066
(show subtarget assignments)

1

expressed

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01067
(show subtarget assignments)

1

expressed

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP01068
(show subtarget assignments)

0

work_stopped

STM3920

16767195

wecB

UDP-N-acetyl glucosamine-2-epimerase

376

Drug Target Function

Phase 2: March 2008

1F6D

85.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01069
(show subtarget assignments)

1

soluble

STM3938

16767209

hemC

porphobilinogen deaminase

318

Conserved Gene / Pathway

Phase 2: March 2008

1AH5

87.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01070
(show subtarget assignments)

1

expressed

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP01071
(show subtarget assignments)

1

in_pdb
3GOA

STM3982

16767252

fadA

3-ketoacyl-CoA thiolase

387

Conserved Gene / Pathway

Phase 2: March 2008

3GOA

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01072
(show subtarget assignments)

1

cloned

STM4003

16767268

yihI

hypothetical protein STM4003

171

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01073
(show subtarget assignments)

1

soluble

STM4044

16767310

putative alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

42.6%

Salmonella enterica

Energy metabolism

Fermentation

IDP01074
(show subtarget assignments)

1

in_pdb
3FPK

STM4084

16767350

fpr

ferredoxin-NADP reductase

248

Conserved Gene / Pathway

Phase 2: March 2008

3FPK

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP01075
(show subtarget assignments)

1

cloned

STM4106

16767372

katG

hydroperoxidase

726

Essential Gene

Phase 2: March 2008

1MWV

64.3%

Salmonella enterica

Cellular processes

Detoxification

IDP01076
(show subtarget assignments)

8

expressed

STM4120

16767385

argE

acetylornithine deacetylase

383

Drug Target Function

Community Requests

3CT9

25.1%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01077
(show subtarget assignments)

0

work_stopped

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01078
(show subtarget assignments)

1

soluble

STM4137

16767396

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

342

Essential Gene

Phase 2: March 2008

1MBB

82.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01079
(show subtarget assignments)

0

work_stopped

STM4167

16767421

hemE

uroporphyrinogen decarboxylase

354

Essential Gene

Phase 2: March 2008

3CYV

96%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01080
(show subtarget assignments)

0

work_stopped

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01081
(show subtarget assignments)

1

soluble

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

3LQ7

24.8%

Salmonella enterica

Cellular processes

Detoxification

IDP01082
(show subtarget assignments)

1

expressed

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP01083
(show subtarget assignments)

1

in_pdb
3OPK

STM4324

16767573

cutA

divalent-cation tolerance protein CutA

115

Conserved Gene / Pathway

Phase 2: March 2008

3OPK

100%

Salmonella enterica

Cellular processes

Detoxification

IDP01084
(show subtarget assignments)

1

purified

STM4377

161353573

aidB

putative acyl-CoA dehydrogenase

546

Conserved Gene / Pathway

Phase 2: March 2008

3DJL

84.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01085
(show subtarget assignments)

1

purified

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP01086
(show subtarget assignments)

1

purified

STM4404

16767650

cysQ

PAPS (adenosine 3'-phosphate 5'-phosphos...

246

Conserved Gene / Pathway

Phase 2: March 2008

3B8B

48.1%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01087
(show subtarget assignments)

1

cloned

STM4465

16767710

ornithine carbamoyltransferase

334

Conserved Gene / Pathway

Phase 2: March 2008

3UPD

75.7%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01088
(show subtarget assignments)

1

expressed

STM4512

16767756

iadA

isoaspartyl dipeptidase

390

Drug Target Function

Phase 2: March 2008

1ONX

81%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01089
(show subtarget assignments)

1

soluble

STM4533

16767777

tsr

methyl-accepting chemotaxis protein I

553

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

38.9%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01090
(show subtarget assignments)

0

work_stopped

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP01091
(show subtarget assignments)

1

purified

STM4578

16767819

serB

phosphoserine phosphatase

322

Conserved Gene / Pathway

Phase 2: March 2008

3N28

47.2%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP01100
(show subtarget assignments)

1

in_pdb
3K1S

BA_5442

30259910

celC-2

PTS system, cellobiose-specific IIA comp...

107

Conserved Gene / Pathway

Phase 2: March 2008

3K1S

99.1%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01101
(show subtarget assignments)

1

expressed

GBAA_pXO1_0119

47566439

hypothetical protein GBAA_pXO1_0119

82

Virulence Associated Factor

Phase 2: March 2008

2K78

34.1%

Bacillus anthracis

IDP01102
(show subtarget assignments)

1

soluble

BA_5424

49040749

Cold shock-like protein cspC

65

Essential Gene

Phase 2: March 2008

1C9O

74.2%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01103
(show subtarget assignments)

1

cloned

BA_1387

47605671

D-alanine--poly(phosphoribitol) ligase s...

79

Drug Target Function

Phase 2: March 2008

1DV5

45.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01104
(show subtarget assignments)

1

soluble

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01105
(show subtarget assignments)

1

soluble

BA_2788

67460529

ATP-dependent Clp protease proteolytic s...

193

Drug Target Function

Phase 2: March 2008

3TT7

67.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01106
(show subtarget assignments)

1

soluble

BA_1846

30256116

msrA-1

peptide methionine sulfoxide reductase

178

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

36%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP01107
(show subtarget assignments)

1

soluble

BA_2250

30256894

heat shock protein, Hsp20 family

153

Conserved Gene / Pathway

Phase 2: March 2008

3AAB

24.2%

Bacillus anthracis

Protein fate

Protein folding and stabilization

Targets