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Targets
Filter Targets:
Selection Phase:
No Filter
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM 10
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
Clostridium difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
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Keyword:
Type Keyword
Stage:
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cloned
crystallized
crystal_structure
diffraction
expressed
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
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CSGID ID
Priority
stage
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91344
(
show subtarget assignments
)
8
expressed
VV2_0026
27366488
hypothetical protein VV2_0026 [Vibrio vu...
168
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00970
(
show subtarget assignments
)
1
soluble
STM1682
16765025
tpx
thiol peroxidase
168
Conserved Gene / Pathway
Phase 2: March 2008
1QXH
87.5%
Salmonella enterica
Cellular processes
Detoxification
IDP90433
(
show subtarget assignments
)
8
cloned
CT_848
3329320
hypothetical protein [Chlamydia trachoma...
168
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01482
(
show subtarget assignments
)
1
in_pdb
3QU1
VCA0150
15600920
def
peptide deformylase
168
Conserved Gene / Pathway
Phase 2: March 2008
3QU1
100%
Vibrio cholerae
Protein fate
Protein modification and repair
IDP91450
(
show subtarget assignments
)
8
expressed
VV1_0385
27363853
putative transposase [Vibrio vulnificus ...
168
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP01129
(
show subtarget assignments
)
1
purified
BA_5296
30259774
ferritin
168
Conserved Gene / Pathway
Phase 2: March 2008
2JD6
48.2%
Bacillus anthracis
Transport and binding proteins
Cations and iron carrying compounds
IDP91579
(
show subtarget assignments
)
8
cloned
BAB37987
13364039
ECs4564
hypothetical protein [Escherichia coli O...
168
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP00403
(
show subtarget assignments
)
1
soluble
YPO1125
16121425
pal
peptidoglycan-associated outer membrane ...
168
Conserved Gene / Pathway
Phase 2: March 2008
1OAP
58.3%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01725
(
show subtarget assignments
)
0
work_stopped
GBAA2534
47527824
acetyltransferase [Bacillus anthracis st...
168
CONSERVED
Phase 3: June 2008
3FBU
100%
Bacillus anthracis
N/A
N/A
IDP90225
(
show subtarget assignments
)
8
in_pdb
3K29
CT670
3329121
Hypothetical
168
Chlamydia type III secretion associated protein CT670
Community Requests
3K29
100%
Chlamydia trachomatis
IDP05386
(
show subtarget assignments
)
1
soluble
BA_2029
30256682
hypothetical protein BA_2029 [Bacillus a...
168
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP90087
(
show subtarget assignments
)
8
cloned
ZZZ_0003
168
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP91571
(
show subtarget assignments
)
8
expressed
BAB35251
13361293
ECs1828
hypothetical protein [Escherichia coli O...
169
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
25.4%
Escherichia coli
IDP01351
(
show subtarget assignments
)
1
cloned
VCA0387
15601150
toxin resistance protein
169
Conserved Gene / Pathway
Phase 2: March 2008
1YVO
31.4%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP02766
(
show subtarget assignments
)
1
cloned
GBAA3318
47528603
hypothetical protein GBAA3318 [Bacillus ...
169
Drug target motif;
Phase 3: June 2008
Bacillus anthracis
N/A
N/A
IDP00880
(
show subtarget assignments
)
0
work_stopped
STM0534
16763914
purE
phosphoribosylaminoimidazole carboxylase...
169
Conserved Gene / Pathway
Phase 2: March 2008
1QCZ
95.3%
Salmonella enterica
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
IDP02347
(
show subtarget assignments
)
1
soluble
YPO1783
16122037
ftnA
ferritin [Yersinia pestis CO92]
169
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3QZ3
68.6%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP05414
(
show subtarget assignments
)
1
expressed
BA_4233
30258736
conserved domain protein [Bacillus anthr...
169
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3OML
33.3%
Bacillus anthracis
Hypothetical proteins: Domain
IDP02352
(
show subtarget assignments
)
1
cloned
FTT1334c
56708390
hypothetical protein FTT1334c [Francisel...
169
Drug Target
Phase 3: June 2008
Francisella tularensis
Unclassified
Role category not yet assigned
IDP01357
(
show subtarget assignments
)
1
in_pdb
3FWX
VC0046
15640078
def
peptide deformylase
169
Conserved Gene / Pathway
Phase 2: March 2008
3FWX
100%
Vibrio cholerae
Protein fate
Protein modification and repair
IDP01310
(
show subtarget assignments
)
1
purified
VC2251
15642249
outer membrane protein OmpH
169
Conserved Gene / Pathway
Phase 2: March 2008
1SG2
30.2%
Vibrio cholerae
Cell envelope
Other
IDP91623
(
show subtarget assignments
)
8
expressed
BAB35652
13361695
ECs2229
hypothetical protein [Escherichia coli O...
169
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
39.1%
Escherichia coli
IDP91923
(
show subtarget assignments
)
8
selected
SpneCM_010100002081
298254388
hypothetical protein SpneCM_02081 [Strep...
170
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
1S3R
31.2%
Streptococcus pneumoniae
IDP05399
(
show subtarget assignments
)
1
expressed
BA_3541
30258076
conserved domain protein [Bacillus anthr...
170
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP00191
(
show subtarget assignments
)
1
cloned
YPO0932
16121236
-
conserved hypothetical protein
170
Virulence
Phase 1: October 2007
Yersinia pestis
Unknown function
Enzymes of unknown specificity
IDP04136
(
show subtarget assignments
)
1
purified
GBAA4258
47529551
5-methylthio-3-oxo-1-penten-1,2-diol dio...
170
putative drug target function;
Phase 4: April 2009
1ZRR
31.8%
Bacillus anthracis
Amino acid biosynthesis
Aspartate family
IDP01858
(
show subtarget assignments
)
1
cloned
CBU_0993
29541575
def
peptide deformylase [Coxiella burnetii R...
170
Conserved; Drug target functions
Phase 3: June 2008
1N5N
47.6%
Coxiella burnetii
Protein fate
Protein modification and repair
IDP02750
(
show subtarget assignments
)
1
cloned
GBAA5389
47530699
transferase hexapeptide domain-containin...
170
Conserved; Essential; Drug target functions
Phase 3: June 2008
1KHR
28.8%
Bacillus anthracis
Central intermediary metabolism
Other
IDP02191
(
show subtarget assignments
)
1
expressed
FTT0878c
56707982
msrB
methionine sulfoxide reductase B [Franci...
170
Drug Target
Phase 3: June 2008
1XM0
47.6%
Francisella tularensis
Cell envelopeProtein fate
Surface structuresProtein modification and repair
IDP01230
(
show subtarget assignments
)
1
purified
BA_4638
33300883
Adenine phosphoribosyltransferase (APRT)...
170
Drug Target Function
Phase 2: March 2008
2DY0
52.4%
Bacillus anthracis
Purines, pyrimidines, nucleosides, and nucleotides
Salvage of nucleosides and nucleotides
IDP91985
(
show subtarget assignments
)
8
selected
SpneCM_010100007069
298255345
collagen adhesion protein [Streptococcus...
171
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP01072
(
show subtarget assignments
)
1
cloned
STM4003
16767268
yihI
hypothetical protein STM4003
171
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP00259
(
show subtarget assignments
)
1
crystallized
CPXV018
30844336
CPXV229 CDS
OMCP protein Cowpox virus
171
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Cowpox virus
IDP04330
(
show subtarget assignments
)
1
soluble
CPF_2086
110799751
stage III sporulation protein SpoAB [Clo...
171
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP05272
(
show subtarget assignments
)
1
purified
lmo1649
16803689
-
hypothetical protein lmo1649 [Listeria m...
171
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP02537
(
show subtarget assignments
)
0
work_stopped
GBAA4558
47778307
nadD
nicotinic acid mononucleotide adenylyltr...
171
Conserved; Drug target functions
Phase 3: June 2008
2QTM
99.4%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Pyridine nucleotides
IDP01304
(
show subtarget assignments
)
1
in_pdb
3HHO
VC0751
15640770
hscB
co-chaperone HscB
171
Conserved Gene / Pathway
Phase 2: March 2008
3HHO
100%
Vibrio cholerae
Protein fate
Protein folding and stabilization
IDP90205
(
show subtarget assignments
)
8
expressed
AAM13465.1
20153004
CPXV018 CDS
CPXV018 protein, VO18
171
similar to MPV-Z-N3R
Community Requests
Cowpox virus
host defense modulator
0
IDP00086
(
show subtarget assignments
)
1
in_pdb
3DR8
3DR6
NT01ST1973
16420114
yncA
putative acyltransferase
171
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3DR6
100%
Salmonella enterica
Transport and binding proteins
Other
IDP02307
(
show subtarget assignments
)
1
cloned
lmo0058
16802106
hypothetical protein lmo0058 [Listeria m...
171
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
Listeria monocytogenes
No Data
No Data
IDP90378
(
show subtarget assignments
)
8
cloned
CT_303
3328719
hypothetical protein [Chlamydia trachoma...
171
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00606
(
show subtarget assignments
)
1
cloned
SACOL1933
57286280
ThiJ/PfpI family protein
171
Drug Target Function
Phase 2: March 2008
1OI4
48.8%
Staphylococcus aureus
Unknown function
General
IDP02172
(
show subtarget assignments
)
1
cloned
YPO0893
16121198
fldB
flavodoxin FldB [Yersinia pestis CO92]
172
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1FLV
46.5%
Yersinia pestis
Energy metabolism
Electron transport
IDP91283
(
show subtarget assignments
)
8
selected
NT05BA5557
49182237
single-stranded DNA-binding protein [Bac...
172
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1UE1
37.8%
Bacillus anthracis
Mobile and extrachromosomal element functions: Prophage functions
IDP01459
(
show subtarget assignments
)
1
soluble
VC2420
161581987
flavodoxin
172
Conserved Gene / Pathway
Phase 2: March 2008
1AG9
45.3%
Vibrio cholerae
Energy metabolism
Electron transport
IDP90427
(
show subtarget assignments
)
8
cloned
CT_847
3329319
hypothetical protein [Chlamydia trachoma...
172
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90635
(
show subtarget assignments
)
8
crystallized
VC1483
15641492
3-hydroxydecanoyl-(acyl carrier protein)...
172
Predicted Essential
Community Requests
1MKA
77.9%
Vibrio cholerae
IDP01330
(
show subtarget assignments
)
1
purified
VC0557
15640579
S-ribosylhomocysteinase
172
Conserved Gene / Pathway
Phase 2: March 2008
1J6W
71.5%
Vibrio cholerae
Cellular processes
Other
IDP90513
(
show subtarget assignments
)
8
in_pdb
3Q62
YPO1430
16121709
fabA
3-hydroxydecanoyl-(acyl carrier protein)...
172
Predicted Essential
Community Requests
3Q62
100%
Yersinia pestis
IDP04073
(
show subtarget assignments
)
1
purified
YPO0502
115346311
conserved hypothetical protein [Yersinia...
172
virulence factor; conserved gene;
Phase 4: April 2009
1Y12
38.4%
Yersinia pestis
Hypothetical proteins
Conserved
IDP01472
(
show subtarget assignments
)
1
cloned
VC2631
15642626
fimbrial assembly protein PilP, putative...
172
Conserved Gene / Pathway
Phase 2: March 2008
2LC4
16.3%
Vibrio cholerae
Cell envelope
Surface structures
IDP05384
(
show subtarget assignments
)
1
cloned
BA_1466
30255398
conserved domain protein [Bacillus anthr...
172
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP05577
(
show subtarget assignments
)
1
soluble
BA_0602
30254206
putative lipoprotein [Bacillus anthracis...
172
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP00629
(
show subtarget assignments
)
1
in_pdb
3QJG
SACOL1875
57284796
epiD
epidermin biosynthesis protein EpiD
172
Conserved Gene / Pathway
Phase 2: March 2008
3QJG
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP02386
(
show subtarget assignments
)
1
selected
GBAA3086
47528378
Signal peptidase I [Bacillus anthracis s...
173
Drug target motif; Drug target functions
Phase 3: June 2008
1B12
10.4%
Bacillus anthracis
Protein fate
Protein and peptide secretion and trafficking
IDP01616
(
show subtarget assignments
)
1
in_pdb
3EG7
VC_A0947
9658384
spermidine n1-acetyltransferase [Vibrio ...
173
CONSERVED
Phase 3: June 2008
3EG7
100%
Vibrio cholerae
N/A
N/A
IDP04172
(
show subtarget assignments
)
1
soluble
VC2268
9656830
riboflavin synthase, beta subunit [Vibri...
173
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3MK3
56.6%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP04294
(
show subtarget assignments
)
1
cloned
YPO3477
115349102
putative lipid carrier protein [Yersinia...
173
conserved gene; putative drug target function;
Phase 4: April 2009
1C44
13.3%
Yersinia pestis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP02519
(
show subtarget assignments
)
1
cloned
GBAA1494
47526768
resA
thiol-disulfide oxidoreductase [Bacillus...
173
Conserved; Drug target functions
Phase 3: June 2008
1ST9
41.6%
Bacillus anthracis
Energy metabolism
Electron transport
IDP01933
(
show subtarget assignments
)
1
soluble
FTT0061
56707240
atpH
F0F1 ATP synthase subunit delta [Francis...
174
Conserved; Drug target functions
Phase 3: June 2008
2WSS
28.2%
Francisella tularensis
Energy metabolism
ATP-proton motive force interconversion
IDP00568
(
show subtarget assignments
)
0
work_stopped
YPO0106
16120453
hslV
ATP-dependent protease peptidase subunit...
174
Conserved Gene / Pathway
Phase 2: March 2008
1E94
90.2%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP04177
(
show subtarget assignments
)
1
purified
VC2629
9657219
shikimate kinase [Vibrio cholerae O1 bio...
174
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1KAG
81%
Vibrio cholerae
Amino acid biosynthesis
Aromatic amino acid family
IDP90522
(
show subtarget assignments
)
8
purified
YPO0310
16120648
ubiC
chorismate pyruvate lyase [Yersinia pest...
174
Predicted Essential
Community Requests
1G1B
50.6%
Yersinia pestis
IDP02161
(
show subtarget assignments
)
1
soluble
FTT0162
56707332
ampD
N-acetyl-anhydromuranmyl-L-alanine amida...
174
Drug Target
Phase 3: June 2008
1J3G
47.7%
Francisella tularensis
Cellular processes
Toxin production and resistance
IDP05071
(
show subtarget assignments
)
1
cloned
CD3291
126700910
hypothetical protein CD3291 [Clostridium...
174
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP90318
(
show subtarget assignments
)
8
purified
CT_718
3329174
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01762
(
show subtarget assignments
)
1
soluble
FTT0557
56707687
AhpC/TSA family protein [Francisella tul...
174
Drug Target
Phase 3: June 2008
1NM3
54%
Francisella tularensis
Cellular processes
Detoxification
IDP02536
(
show subtarget assignments
)
1
in_pdb
3KUU
YPO3076
16123253
purE
phosphoribosylaminoimidazole carboxylase...
174
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
3KUU
99.4%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
IDP00845
(
show subtarget assignments
)
1
soluble
SACOL0968
57285842
spsA
signal peptidase IA, inactive
174
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
Protein fate
Protein and peptide secretion and trafficking
IDP00844
(
show subtarget assignments
)
1
diffraction
SACOL0519
57285544
acetyltransferase, GNAT family
174
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP04668
(
show subtarget assignments
)
1
cloned
GBAA1327
47526592
phaP protein [Bacillus anthracis str. 'A...
174
conserved gene; putative drug target function;
Phase 4: April 2009
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP05688
(
show subtarget assignments
)
1
soluble
lmo1601
16803641
-
hypothetical protein lmo1601 [Listeria m...
174
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Cellular processes: Adaptations to atypical conditions
IDP90317
(
show subtarget assignments
)
8
cloned
CT_724
3329181
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02562
(
show subtarget assignments
)
1
purified
STM0924
16764286
putative CuZn superoxide dismutase [Salm...
174
Conserved; Drug target functions
Phase 3: June 2008
2WN0
60.3%
Salmonella enterica
Cellular processes
Detoxification
IDP90393
(
show subtarget assignments
)
8
cloned
CT_567
3329008
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP05451
(
show subtarget assignments
)
1
soluble
BA_0580
30254186
putative lipoprotein [Bacillus anthracis...
174
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP91206
(
show subtarget assignments
)
8
in_pdb
3VAA
BT_3393
29348802
shikimate kinase [Bacteroides thetaiotao...
175
potential drug target /
Shikimate pathway enzyme
Community Requests
3VAA
100%
Bacteroides thetaiotaomicron
IDP01446
(
show subtarget assignments
)
1
purified
VC2099
15642099
flavodoxin FldA
175
Conserved Gene / Pathway
Phase 2: March 2008
1AG9
75.4%
Vibrio cholerae
Energy metabolism
Electron transport
IDP02151
(
show subtarget assignments
)
1
cloned
GBAA3159
47528451
hypothetical protein GBAA3159 [Bacillus ...
175
Drug target motif; Involved in sporulation;
Phase 3: June 2008
Bacillus anthracis
Hypothetical proteins
Conserved
IDP90309
(
show subtarget assignments
)
8
cloned
CT_702
3329157
hypothetical protein [Chlamydia trachoma...
175
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00785
(
show subtarget assignments
)
1
purified
SACOL0904
57285780
pathogenicity island protein
175
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Pathogenesis
IDP91281
(
show subtarget assignments
)
8
selected
NT05BA5437
49182125
RNA polymerase sigma-70 factor, ECF subf...
175
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1OR7
22.5%
Bacillus anthracis
Unclassified: Role category not yet assigned
IDP00637
(
show subtarget assignments
)
1
cloned
SACOL1727
57284738
infC
translation initiation factor IF-3
175
Drug Target Function
Phase 2: March 2008
1TIG
37.7%
Staphylococcus aureus
Protein synthesis
Translation factors
IDP04534
(
show subtarget assignments
)
8
selected
CAC05815
12329084
mxiK
MxiK, putative component of the Mxi-Spa ...
175
Shigella effector protein
Community Requests
Shigella flexneri
IDP04063
(
show subtarget assignments
)
1
cloned
CPF_0514
110800714
putative lipoprotein [Clostridium perfri...
176
drug target; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cell envelope
Other
IDP90150
(
show subtarget assignments
)
8
cloned
MPXV_ZAI1979_005_202
68449275
unknown [Monkeypox virus]
176
similar to CPXV-GRI-C2L, MPXV-ZAI96-N3R
Community Requests
Monkeypox virus
IDP00260
(
show subtarget assignments
)
1
purified
AF380138
17529967
N3R
N3R [Monkeypox virus]
176
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
Monkeypox virus
IDP04194
(
show subtarget assignments
)
1
cloned
CPF_2444
110799147
yyaC
putative sporulation protein YyaC [Clost...
176
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP90997
(
show subtarget assignments
)
8
soluble
y1682
22125577
ompX
outer membrane protein X [Yersinia pesti...
176
virulence/pathogenesis /
putative cell surface adhesin in various Gram-negative pathogens
Community Requests
1ORM
59.1%
Yersinia pestis
IDP00496
(
show subtarget assignments
)
1
cloned
YPO1699
16121959
hypothetical protein YPO1699
176
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Other
IDP90132
(
show subtarget assignments
)
8
expressed
MPXV_ZAI1979_005_155
68449229
unknown [Monkeypox virus]
176
similar to VACV-COP-A35R, MPXV-ZAI96-A37R
Community Requests
Monkeypox virus
IDP90115
(
show subtarget assignments
)
8
soluble
MPXV_ZAI1979_005_024
68449098
kelch-like protein [Monkeypox virus]
176
similar to MPXV-ZAI96-D18L, part of VACV-COP-C2L
Community Requests
2XN4
26.1%
Monkeypox virus
IDP05183
(
show subtarget assignments
)
1
soluble
BA_5237
30259716
putative lipoprotein [Bacillus anthracis...
176
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP02271
(
show subtarget assignments
)
1
purified
FTT1155c
56708226
aroK
shikimate kinase I [Francisella tularens...
176
Conserved; Drug target functions
Phase 3: June 2008
1KAG
58%
Francisella tularensis
Amino acid biosynthesis
Aromatic amino acid family
IDP01886
(
show subtarget assignments
)
1
purified
STM0085
16763475
yabF
glutathione-regulated potassium-efflux s...
176
Conserved; Drug target functions
Phase 3: June 2008
3EYW
87.5%
Salmonella enterica
Energy metabolism
Electron transport
IDP90118
(
show subtarget assignments
)
8
soluble
MPXV_ZAI1979_005_028
68449102
alpha-amanitin target protein [Monkeypox...
177
similar to VACV-COP-N2L, MPXV-ZAI96-P2L
Community Requests
Monkeypox virus
IDP91467
(
show subtarget assignments
)
8
expressed
VPA1367
28901222
putative type III secretion system lipop...
177
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP05275
(
show subtarget assignments
)
1
cloned
lmo2686
16804723
-
hypothetical protein lmo2686 [Listeria m...
177
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP90863
(
show subtarget assignments
)
8
cloned
YPO3761
16123898
hemG
protoporphyrinogen oxidase [Yersinia pes...
177
Predicted Essential
Community Requests
Yersinia pestis
IDP90167
(
show subtarget assignments
)
8
purified
CD1838
123066836
Shikimate kinase
177
Potential drug target. Shikimate pathway enzyme
Community Requests
2PT5
31.6%
Clostridium difficile
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