Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04049 (show subtarget assignments)	1	soluble	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP02060 (show subtarget assignments)	1	expressed	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00749 (show subtarget assignments)	1	in_pdb 3PGY	SACOL2105	57286321	glyA	serine hydroxymethyltransferase	412	Drug Target Function	Phase 2: March 2008	3PGY	99.8%	Staphylococcus aureus	Amino acid biosynthesis	Serine family

IDP02042 (show subtarget assignments)	1	cloned	CBU_0875	29541467	asd	aspartate-semialdehyde dehydrogenase [Co...	340	Conserved; Drug target functions	Phase 3: June 2008	2QZ9	61.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02764 (show subtarget assignments)	1	expressed	CBU_0525	29541128	serC	phosphoserine aminotransferase [Coxiella...	360	Conserved; Drug target functions	Phase 3: June 2008	3QBO	53.6%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP01199 (show subtarget assignments)	1	purified	BA_1537	67460530		Chorismate synthase 1 (5-enolpyruvylshik...	390	Drug Target Function	Phase 2: March 2008	1QXO	59%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02337 (show subtarget assignments)	1	purified	GBAA1511	47526786	gdhA	glutamate dehydrogenase [Bacillus anthra...	428	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K8Z	84.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02736 (show subtarget assignments)	1	cloned	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02718 (show subtarget assignments)	1	cloned	GBAA3833	47529118	glnA	glutamine synthetase, type I [Bacillus a...	444	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1LGR	44.6%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP00350 (show subtarget assignments)	1	purified	lmo1633	16803673	trpE	anthranilate synthase component I	454	Drug Target Function	Phase 2: March 2008	1QDL	35.7%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00349 (show subtarget assignments)	1	expressed	lmo1632	16803672	trpG	hypothetical protein lmo1632	201	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1I1Q	39.3%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00348 (show subtarget assignments)	1	in_pdb 3TFC 3NVT	lmo1600	16803640	aroA	bifunctional 3-deoxy-7-phosphoheptulonat...	361	Drug Target Function	Phase 2: March 2008	3NVT	100%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP02670 (show subtarget assignments)	1	cloned	GBAA4353	47529649	argB	acetylglutamate kinase [Bacillus anthrac...	255	Conserved; Drug target functions	Phase 3: June 2008	2BTY	43.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02667 (show subtarget assignments)	1	cloned	lmo0565	16802608	hisH	imidazole glycerol phosphate synthase su...	208	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	1OX4	33.5%	Listeria monocytogenes	Amino acid biosynthesis	Histidine family

IDP02669 (show subtarget assignments)	1	purified	GBAA1568	50196927	aspB	aspartate aminotransferase [Bacillus ant...	395	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J32	45.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02676 (show subtarget assignments)	1	crystallized	GBAA1539	47526813	hisC-1	histidinol-phosphate aminotransferase [B...	370	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3FFH	46.2%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP00342 (show subtarget assignments)	1	cloned	FTT1802c	56708788	trpE	anthranilate synthase component I	514	Drug Target Function	Phase 2: March 2008	1I1Q	51.1%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02636 (show subtarget assignments)	1	expressed	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00338 (show subtarget assignments)	1	cloned	FTT0876c	56707980	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1UM0	47.4%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP01610 (show subtarget assignments)	1	in_pdb 3I1I	GBAA4983	47778350		homoserine O-acetyltransferase [Bacillus...	374	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I1I	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP00337 (show subtarget assignments)	1	expressed	FTT0946	56708043	trpG	anthranilate synthase component II	184	Drug Target Function	Phase 2: March 2008	1QDL	40.7%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02625 (show subtarget assignments)	1	cloned	GBAA4457	47529752	aroK	shikimate kinase [Bacillus anthracis str...	165	Conserved; Drug target functions	Phase 3: June 2008	1ZUH	35.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01631 (show subtarget assignments)	1	soluble	CBU_2024	29542577		cystathionine beta-synthase, putative [C...	316	Conserved; Drug target functions	Phase 3: June 2008	1JBQ	60.9%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP02649 (show subtarget assignments)	1	purified	STM1795	16765136		putative glutamic dehyrogenase-like prot...	441	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3AOE	58.5%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01627 (show subtarget assignments)	1	cloned	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01196 (show subtarget assignments)	1	expressed	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02612 (show subtarget assignments)	0	work_stopped	GBAA5170	50196964	dapF	diaminopimelate epimerase [Bacillus anth...	288	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OTN	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP00330 (show subtarget assignments)	1	soluble	Cj0345	15791713	trpE	putative anthranilate synthase component...	416	Drug Target Function	Phase 2: March 2008	1QDL	32%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP02318 (show subtarget assignments)	1	purified	GBAA1251	47526517	trpC	indole-3-glycerol-phosphate synthase [Ba...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TSM	40.7%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00329 (show subtarget assignments)	1	cloned	Cj1724c	15793027		7-cyano-7-deazaguanine reductase	127	Drug Target Function	Phase 2: March 2008			Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP02652 (show subtarget assignments)	1	expressed	GBAA1422	47526694	leuC	isopropylmalate isomerase large subunit ...	464	Conserved; Drug target functions	Phase 3: June 2008	2B3X	22%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP00009 (show subtarget assignments)	1	soluble	BA_1538	38372188		3-dehydroquinate synthase	363	Drug Target Homolog	Phase 1: October 2007	1XAG	38.3%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00326 (show subtarget assignments)	0	work_stopped	Cj1607	15792912	ispDF	bifunctional 2-C-methyl-D-erythritol 4-p...	371	Drug Target Function	Phase 2: March 2008	1W55	100%	Campylobacter jejuni	Amino acid biosynthesis	Histidine family

IDP01883 (show subtarget assignments)	1	expressed	STM0116	16763506	ilvI	acetolactate synthase 3 catalytic subuni...	553	Conserved; Drug target functions	Phase 3: June 2008	1JSC	43.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP00322 (show subtarget assignments)	1	expressed	Cj0346	15791714	trpD	anthranilate synthase component II	533	Drug Target Function	Phase 2: March 2008	1VQU	20.6%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP00319 (show subtarget assignments)	1	expressed	CBU_2070	29655348		chorismate mutase, putative	136	Drug Target Function	Phase 2: March 2008			Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01512 (show subtarget assignments)	1	soluble	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP00316 (show subtarget assignments)	1	purified	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00315 (show subtarget assignments)	1	purified	CBU_0874	29654200	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1R52	44.7%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02604 (show subtarget assignments)	1	expressed	CBU_1893	29542450	aroB	3-dehydroquinate synthase [Coxiella burn...	360	Conserved; Drug target functions	Phase 3: June 2008	3OKF	48.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02541 (show subtarget assignments)	1	expressed	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00068 (show subtarget assignments)	0	work_stopped	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP02524 (show subtarget assignments)	1	purified	GBAA1852	47527143	ilvC-2	ketol-acid reductoisomerase [Bacillus an...	335	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	56.1%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02525 (show subtarget assignments)	1	crystallized	GBAA4351	47529646	argF	ornithine carbamoyltransferase [Bacillus...	316	Conserved; Drug target functions	Phase 3: June 2008	1A1S	55.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01984 (show subtarget assignments)	1	expressed	CBU_0831	29541425	asnB-1	asparagine synthetase B, glutamine-hydro...	632	Conserved; Drug target functions	Phase 3: June 2008	1CT9	18.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02497 (show subtarget assignments)	1	cloned	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	1FCJ	31.3%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP01813 (show subtarget assignments)	1	purified	GBAA1253	47526519	trpB	tryptophan synthase subunit beta [Bacill...	397	Conserved; Drug target functions	Phase 3: June 2008	1X1Q	63%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00302 (show subtarget assignments)	1	expressed	CBU_1155	29654460	trpBF	N-(5'phosphoribosyl)anthranilate isomera...	600	Drug Target Function	Phase 2: March 2008	1V8Z	38%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02501 (show subtarget assignments)	1	cloned	GBAA1250	47526516	trpD	anthranilate phosphoribosyltransferase [...	341	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VQU	39.6%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02483 (show subtarget assignments)	1	cloned	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02487 (show subtarget assignments)	1	cloned	GBAA4218	47529511	metE	5-methyltetrahydropteroyltriglutamate--h...	762	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2NQ5	51.3%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02467 (show subtarget assignments)	1	soluble	GBAA3937	47529228	asd-2	aspartate-semialdehyde dehydrogenase [Ba...	348	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GYY	60.6%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01866 (show subtarget assignments)	1	crystallized	FTT1772c	56708766	trpA	tryptophan synthase subunit alpha [Franc...	269	Drug Target	Phase 3: June 2008	3NAV	61%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02488 (show subtarget assignments)	1	purified	GBAA1425	47526697	hisG	ATP phosphoribosyltransferase catalytic ...	211	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1Z7M	49.8%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02320 (show subtarget assignments)	1	purified	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02492 (show subtarget assignments)	1	crystallized	FTT1559c	56708586	proC	pyrroline-5-carboxylate reductase [Franc...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	37.6%	Francisella tularensis	Amino acid biosynthesis	Glutamate family

IDP02535 (show subtarget assignments)	1	expressed	GBAA0088	47525343	cysE	serine O-acetyltransferase [Bacillus ant...	221	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GVD	36.2%	Bacillus anthracis	Amino acid biosynthesis	Serine family

IDP91230 (show subtarget assignments)	8	selected	NT04EC2956	26109123	aroC	Chorismate synthase [Escherichia coli CF...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	46.5%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91228 (show subtarget assignments)	8	selected	NT04EC3200	26109368	pheA	P-protein [Escherichia coli CFT073]	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	28.2%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91227 (show subtarget assignments)	8	selected	NT04EC3201	26109369	tyrA	T-protein [Escherichia coli CFT073]	373	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2PV7	45.3%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91258 (show subtarget assignments)	8	selected	NT02SA1455	14247237	aroC	chorismate synthase [Staphylococcus aure...	388	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1QXO	56.7%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP91251 (show subtarget assignments)	8	selected	NT01LM1754	16411067	trpD	trpD [Listeria monocytogenes]	339	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	41.2%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP91244 (show subtarget assignments)	8	selected	HP0663	0			365	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1UM0	100%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP91257 (show subtarget assignments)	8	selected	NT02SA1359	14247140	trpD	anthranilate phosphoribosyltransferase [...	332	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	33.8%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP91233 (show subtarget assignments)	8	selected	NT04EC1775	26107994	trpD	Anthranilate synthase component II [Esch...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP05722 (show subtarget assignments)	1	purified	BA_2954	30257545	tyrA	prephenate dehydrogenase [Bacillus anthr...	378	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DZB	32%	Bacillus anthracis	Amino acid biosynthesis: Aromatic amino acid family

IDP91238 (show subtarget assignments)	8	selected	HP1282	2314448		anthranilate synthase component I (trpE)...	500	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	46.8%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP91240 (show subtarget assignments)	8	selected	HP1280	0			335	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	39.4%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP91232 (show subtarget assignments)	8	selected	NT04EC1776	26107995	trpE	Anthranilate synthase component I [Esche...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.6%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP05341 (show subtarget assignments)	1	cloned	lmo1928	16803967	aroF	chorismate synthase [Listeria monocytoge...	388	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1QXO	63.1%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP02437 (show subtarget assignments)	1	expressed	FTT1226c	56708288	iscS	cysteine desulfarase [Francisella tulare...	391	Drug Target	Phase 3: June 2008	1P3W	41.9%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Pyruvate familyOther

IDP01849 (show subtarget assignments)	1	in_pdb 3L07	FTT0892	56707993	folD	methylenetetrahydrofolate dehydrogenase/...	282	Conserved; Drug target functions	Phase 3: June 2008	3L07	100%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Aspartate familyFolic acid

IDP02434 (show subtarget assignments)	1	soluble	FTT1241	56708303	glyA	serine hydroxymethyltransferase [Francis...	417	Drug Target	Phase 3: June 2008	3GBX	67.1%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin	Serine familyFolic acid,Purine ribonucleotide biosynthesis

IDP02323 (show subtarget assignments)	1	soluble	FTT0560c	56707690	serC	phosphoserine aminotransferase [Francise...	350	Drug Target	Phase 3: June 2008	3QBO	41.1%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism	Aspartate familyOther

IDP02232 (show subtarget assignments)	1	expressed	FTT1050c	56708136	cysN	sulfate adenylate transferase subunit 1 ...	470	Drug Target	Phase 3: June 2008	1ZUN	56%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo	Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP01871 (show subtarget assignments)	1	cloned	FTT1795c	56708783	trpC	bifunctional indole-3-glycerol phosphate...	453	Conserved; Drug target functions	Phase 3: June 2008	1PII	56.1%	Francisella tularensis	Amino acid biosynthesisFatty acid and phospholipid metabolism	Aromatic amino acid familyHistidine family,Biosynthesis

IDP02405 (show subtarget assignments)	1	purified	FTT1803c	56708789	trpR	trp operon repressor [Francisella tulare...	95	Drug Target	Phase 3: June 2008	1CO0	30.5%	Francisella tularensis	Amino acid biosynthesisRegulatory functions	Aromatic amino acid familyDNA interactions

IDP05497 (show subtarget assignments)	1	cloned	CD0241	126697812		phosphoserine phosphatase [Clostridium d...	205	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5S	32.1%	Clostridium difficile	Amino acid biosynthesis: Serine family

IDP00582 (show subtarget assignments)	1	in_pdb 3GSE	YPO2528	16122747	menF	menaquinone-specific isochorismate synth...	455	Conserved Gene / Pathway	Phase 2: March 2008	3GSE	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00580 (show subtarget assignments)	1	soluble	YPO0059	16120412	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	403	Conserved Gene / Pathway	Phase 2: March 2008	1FC4	82.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01850 (show subtarget assignments)	1	cloned	FTT0916c	56708017	ribF	riboflavin biosynthesis protein RibF [Fr...	306	Drug Target	Phase 3: June 2008	1MRZ	30.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01079 (show subtarget assignments)	0	work_stopped	STM4167	16767421	hemE	uroporphyrinogen decarboxylase	354	Essential Gene	Phase 2: March 2008	3CYV	96%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01436 (show subtarget assignments)	1	crystallized	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02227 (show subtarget assignments)	1	cloned	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02242 (show subtarget assignments)	1	cloned	Cj0320	15791688	fliH	flagellar assembly protein H [Campylobac...	276	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01069 (show subtarget assignments)	1	soluble	STM3938	16767209	hemC	porphobilinogen deaminase	318	Conserved Gene / Pathway	Phase 2: March 2008	1AH5	87.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01958 (show subtarget assignments)	1	expressed	FTT0937c	56708034	bioB	biotin synthase [Francisella tularensis ...	313	Drug Target	Phase 3: June 2008	1R30	49.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01063 (show subtarget assignments)	1	soluble	STM3702	16766987	grxC	glutaredoxin 3	83	Conserved Gene / Pathway	Phase 2: March 2008	1FOV	86.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP00559 (show subtarget assignments)	1	purified	YPO3032	16123209	hemF	coproporphyrinogen III oxidase	309	Conserved Gene / Pathway	Phase 2: March 2008	3E8J	59.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01059 (show subtarget assignments)	1	soluble	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02257 (show subtarget assignments)	1	expressed	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02217 (show subtarget assignments)	1	expressed	FTT1018c	56708107	dxs	1-deoxy-D-xylulose-5-phosphate synthase ...	615	Conserved; Drug target functions	Phase 3: June 2008	2O1S	56.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	OtherPyridoxine,Thiamine

IDP02423 (show subtarget assignments)	1	cloned	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02213 (show subtarget assignments)	1	expressed	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00555 (show subtarget assignments)	1	purified	YPO3424	16123573	nadC	quinolinate phosphoribosyltransferase	302	Conserved Gene / Pathway	Phase 2: March 2008	1QAP	72.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01753 (show subtarget assignments)	1	expressed	CBU_0423	29541032	panC	pantoate--beta-alanine ligase [Coxiella ...	257	Conserved; Drug target functions	Phase 3: June 2008	3N8H	40.9%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02218 (show subtarget assignments)	1	expressed	GBAA2133	47778008	narA-1	molybdenum cofactor biosynthesis protein...	337	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TV7	54.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02416 (show subtarget assignments)	1	purified	FTT1259	56708321	nadE	NH(3)-dependent NAD(+) synthetase [Franc...	249	Conserved; Drug target functions	Phase 3: June 2008	3FIU	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02424 (show subtarget assignments)	1	cloned	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01044 (show subtarget assignments)	1	soluble	STM3070	16766371	epd	D-erythrose 4-phosphate dehydrogenase	348	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	91.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04049
(show subtarget assignments)

1

soluble

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP02060
(show subtarget assignments)

1

expressed

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP00749
(show subtarget assignments)

1

in_pdb
3PGY

SACOL2105

57286321

glyA

serine hydroxymethyltransferase

412

Drug Target Function

Phase 2: March 2008

3PGY

99.8%

Staphylococcus aureus

Amino acid biosynthesis

Serine family

IDP02042
(show subtarget assignments)

1

cloned

CBU_0875

29541467

asd

aspartate-semialdehyde dehydrogenase [Co...

340

Conserved; Drug target functions

Phase 3: June 2008

2QZ9

61.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02764
(show subtarget assignments)

1

expressed

CBU_0525

29541128

serC

phosphoserine aminotransferase [Coxiella...

360

Conserved; Drug target functions

Phase 3: June 2008

3QBO

53.6%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP01199
(show subtarget assignments)

1

purified

BA_1537

67460530

Chorismate synthase 1 (5-enolpyruvylshik...

390

Drug Target Function

Phase 2: March 2008

1QXO

59%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02337
(show subtarget assignments)

1

purified

GBAA1511

47526786

gdhA

glutamate dehydrogenase [Bacillus anthra...

428

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K8Z

84.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02736
(show subtarget assignments)

1

cloned

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02718
(show subtarget assignments)

1

cloned

GBAA3833

47529118

glnA

glutamine synthetase, type I [Bacillus a...

444

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1LGR

44.6%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP00350
(show subtarget assignments)

1

purified

lmo1633

16803673

trpE

anthranilate synthase component I

454

Drug Target Function

Phase 2: March 2008

1QDL

35.7%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00349
(show subtarget assignments)

1

expressed

lmo1632

16803672

trpG

hypothetical protein lmo1632

201

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1I1Q

39.3%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00348
(show subtarget assignments)

1

in_pdb
3TFC
3NVT

lmo1600

16803640

aroA

bifunctional 3-deoxy-7-phosphoheptulonat...

361

Drug Target Function

Phase 2: March 2008

3NVT

100%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP02670
(show subtarget assignments)

1

cloned

GBAA4353

47529649

argB

acetylglutamate kinase [Bacillus anthrac...

255

Conserved; Drug target functions

Phase 3: June 2008

2BTY

43.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02667
(show subtarget assignments)

1

cloned

lmo0565

16802608

hisH

imidazole glycerol phosphate synthase su...

208

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

1OX4

33.5%

Listeria monocytogenes

Amino acid biosynthesis

Histidine family

IDP02669
(show subtarget assignments)

1

purified

GBAA1568

50196927

aspB

aspartate aminotransferase [Bacillus ant...

395

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J32

45.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02676
(show subtarget assignments)

1

crystallized

GBAA1539

47526813

hisC-1

histidinol-phosphate aminotransferase [B...

370

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3FFH

46.2%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP00342
(show subtarget assignments)

1

cloned

FTT1802c

56708788

trpE

anthranilate synthase component I

514

Drug Target Function

Phase 2: March 2008

1I1Q

51.1%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02636
(show subtarget assignments)

1

expressed

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00338
(show subtarget assignments)

1

cloned

FTT0876c

56707980

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1UM0

47.4%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP01610
(show subtarget assignments)

1

in_pdb
3I1I

GBAA4983

47778350

homoserine O-acetyltransferase [Bacillus...

374

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I1I

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP00337
(show subtarget assignments)

1

expressed

FTT0946

56708043

trpG

anthranilate synthase component II

184

Drug Target Function

Phase 2: March 2008

1QDL

40.7%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02625
(show subtarget assignments)

1

cloned

GBAA4457

47529752

aroK

shikimate kinase [Bacillus anthracis str...

165

Conserved; Drug target functions

Phase 3: June 2008

1ZUH

35.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01631
(show subtarget assignments)

1

soluble

CBU_2024

29542577

cystathionine beta-synthase, putative [C...

316

Conserved; Drug target functions

Phase 3: June 2008

1JBQ

60.9%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP02649
(show subtarget assignments)

1

purified

STM1795

16765136

putative glutamic dehyrogenase-like prot...

441

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3AOE

58.5%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01627
(show subtarget assignments)

1

cloned

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP01196
(show subtarget assignments)

1

expressed

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02612
(show subtarget assignments)

0

work_stopped

GBAA5170

50196964

dapF

diaminopimelate epimerase [Bacillus anth...

288

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OTN

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP00330
(show subtarget assignments)

1

soluble

Cj0345

15791713

trpE

putative anthranilate synthase component...

416

Drug Target Function

Phase 2: March 2008

1QDL

32%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP02318
(show subtarget assignments)

1

purified

GBAA1251

47526517

trpC

indole-3-glycerol-phosphate synthase [Ba...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TSM

40.7%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00329
(show subtarget assignments)

1

cloned

Cj1724c

15793027

7-cyano-7-deazaguanine reductase

127

Drug Target Function

Phase 2: March 2008

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP02652
(show subtarget assignments)

1

expressed

GBAA1422

47526694

leuC

isopropylmalate isomerase large subunit ...

464

Conserved; Drug target functions

Phase 3: June 2008

2B3X

22%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP00009
(show subtarget assignments)

1

soluble

BA_1538

38372188

3-dehydroquinate synthase

363

Drug Target Homolog

Phase 1: October 2007

1XAG

38.3%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00326
(show subtarget assignments)

0

work_stopped

Cj1607

15792912

ispDF

bifunctional 2-C-methyl-D-erythritol 4-p...

371

Drug Target Function

Phase 2: March 2008

1W55

100%

Campylobacter jejuni

Amino acid biosynthesis

Histidine family

IDP01883
(show subtarget assignments)

1

expressed

STM0116

16763506

ilvI

acetolactate synthase 3 catalytic subuni...

553

Conserved; Drug target functions

Phase 3: June 2008

1JSC

43.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP00322
(show subtarget assignments)

1

expressed

Cj0346

15791714

trpD

anthranilate synthase component II

533

Drug Target Function

Phase 2: March 2008

1VQU

20.6%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP00319
(show subtarget assignments)

1

expressed

CBU_2070

29655348

chorismate mutase, putative

136

Drug Target Function

Phase 2: March 2008

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01512
(show subtarget assignments)

1

soluble

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP00316
(show subtarget assignments)

1

purified

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00315
(show subtarget assignments)

1

purified

CBU_0874

29654200

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1R52

44.7%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02604
(show subtarget assignments)

1

expressed

CBU_1893

29542450

aroB

3-dehydroquinate synthase [Coxiella burn...

360

Conserved; Drug target functions

Phase 3: June 2008

3OKF

48.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02541
(show subtarget assignments)

1

expressed

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP00068
(show subtarget assignments)

0

work_stopped

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP02524
(show subtarget assignments)

1

purified

GBAA1852

47527143

ilvC-2

ketol-acid reductoisomerase [Bacillus an...

335

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

56.1%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02525
(show subtarget assignments)

1

crystallized

GBAA4351

47529646

argF

ornithine carbamoyltransferase [Bacillus...

316

Conserved; Drug target functions

Phase 3: June 2008

1A1S

55.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP01984
(show subtarget assignments)

1

expressed

CBU_0831

29541425

asnB-1

asparagine synthetase B, glutamine-hydro...

632

Conserved; Drug target functions

Phase 3: June 2008

1CT9

18.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02497
(show subtarget assignments)

1

cloned

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

1FCJ

31.3%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP01813
(show subtarget assignments)

1

purified

GBAA1253

47526519

trpB

tryptophan synthase subunit beta [Bacill...

397

Conserved; Drug target functions

Phase 3: June 2008

1X1Q

63%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00302
(show subtarget assignments)

1

expressed

CBU_1155

29654460

trpBF

N-(5'phosphoribosyl)anthranilate isomera...

600

Drug Target Function

Phase 2: March 2008

1V8Z

38%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02501
(show subtarget assignments)

1

cloned

GBAA1250

47526516

trpD

anthranilate phosphoribosyltransferase [...

341

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VQU

39.6%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02483
(show subtarget assignments)

1

cloned

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02487
(show subtarget assignments)

1

cloned

GBAA4218

47529511

metE

5-methyltetrahydropteroyltriglutamate--h...

762

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2NQ5

51.3%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02467
(show subtarget assignments)

1

soluble

GBAA3937

47529228

asd-2

aspartate-semialdehyde dehydrogenase [Ba...

348

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GYY

60.6%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01866
(show subtarget assignments)

1

crystallized

FTT1772c

56708766

trpA

tryptophan synthase subunit alpha [Franc...

269

Drug Target

Phase 3: June 2008

3NAV

61%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02488
(show subtarget assignments)

1

purified

GBAA1425

47526697

hisG

ATP phosphoribosyltransferase catalytic ...

211

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1Z7M

49.8%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02320
(show subtarget assignments)

1

purified

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02492
(show subtarget assignments)

1

crystallized

FTT1559c

56708586

proC

pyrroline-5-carboxylate reductase [Franc...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

37.6%

Francisella tularensis

Amino acid biosynthesis

Glutamate family

IDP02535
(show subtarget assignments)

1

expressed

GBAA0088

47525343

cysE

serine O-acetyltransferase [Bacillus ant...

221

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GVD

36.2%

Bacillus anthracis

Amino acid biosynthesis

Serine family

IDP91230
(show subtarget assignments)

8

selected

NT04EC2956

26109123

aroC

Chorismate synthase [Escherichia coli CF...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

46.5%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91228
(show subtarget assignments)

8

selected

NT04EC3200

26109368

pheA

P-protein [Escherichia coli CFT073]

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

28.2%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91227
(show subtarget assignments)

8

selected

NT04EC3201

26109369

tyrA

T-protein [Escherichia coli CFT073]

373

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2PV7

45.3%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91258
(show subtarget assignments)

8

selected

NT02SA1455

14247237

aroC

chorismate synthase [Staphylococcus aure...

388

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1QXO

56.7%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP91251
(show subtarget assignments)

8

selected

NT01LM1754

16411067

trpD

trpD [Listeria monocytogenes]

339

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

41.2%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP91244
(show subtarget assignments)

8

selected

HP0663

0

365

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1UM0

100%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP91257
(show subtarget assignments)

8

selected

NT02SA1359

14247140

trpD

anthranilate phosphoribosyltransferase [...

332

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

33.8%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP91233
(show subtarget assignments)

8

selected

NT04EC1775

26107994

trpD

Anthranilate synthase component II [Esch...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP05722
(show subtarget assignments)

1

purified

BA_2954

30257545

tyrA

prephenate dehydrogenase [Bacillus anthr...

378

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DZB

32%

Bacillus anthracis

Amino acid biosynthesis: Aromatic amino acid family

IDP91238
(show subtarget assignments)

8

selected

HP1282

2314448

anthranilate synthase component I (trpE)...

500

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

46.8%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP91240
(show subtarget assignments)

8

selected

HP1280

0

335

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

39.4%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP91232
(show subtarget assignments)

8

selected

NT04EC1776

26107995

trpE

Anthranilate synthase component I [Esche...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.6%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP05341
(show subtarget assignments)

1

cloned

lmo1928

16803967

aroF

chorismate synthase [Listeria monocytoge...

388

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1QXO

63.1%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP02437
(show subtarget assignments)

1

expressed

FTT1226c

56708288

iscS

cysteine desulfarase [Francisella tulare...

391

Drug Target

Phase 3: June 2008

1P3W

41.9%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Pyruvate familyOther

IDP01849
(show subtarget assignments)

1

in_pdb
3L07

FTT0892

56707993

folD

methylenetetrahydrofolate dehydrogenase/...

282

Conserved; Drug target functions

Phase 3: June 2008

3L07

100%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Aspartate familyFolic acid

IDP02434
(show subtarget assignments)

1

soluble

FTT1241

56708303

glyA

serine hydroxymethyltransferase [Francis...

417

Drug Target

Phase 3: June 2008

3GBX

67.1%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin

Serine familyFolic acid,Purine ribonucleotide biosynthesis

IDP02323
(show subtarget assignments)

1

soluble

FTT0560c

56707690

serC

phosphoserine aminotransferase [Francise...

350

Drug Target

Phase 3: June 2008

3QBO

41.1%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism

Aspartate familyOther

IDP02232
(show subtarget assignments)

1

expressed

FTT1050c

56708136

cysN

sulfate adenylate transferase subunit 1 ...

470

Drug Target

Phase 3: June 2008

1ZUN

56%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo

Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP01871
(show subtarget assignments)

1

cloned

FTT1795c

56708783

trpC

bifunctional indole-3-glycerol phosphate...

453

Conserved; Drug target functions

Phase 3: June 2008

1PII

56.1%

Francisella tularensis

Amino acid biosynthesisFatty acid and phospholipid metabolism

Aromatic amino acid familyHistidine family,Biosynthesis

IDP02405
(show subtarget assignments)

1

purified

FTT1803c

56708789

trpR

trp operon repressor [Francisella tulare...

95

Drug Target

Phase 3: June 2008

1CO0

30.5%

Francisella tularensis

Amino acid biosynthesisRegulatory functions

Aromatic amino acid familyDNA interactions

IDP05497
(show subtarget assignments)

1

cloned

CD0241

126697812

phosphoserine phosphatase [Clostridium d...

205

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5S

32.1%

Clostridium difficile

Amino acid biosynthesis: Serine family

IDP00582
(show subtarget assignments)

1

in_pdb
3GSE

YPO2528

16122747

menF

menaquinone-specific isochorismate synth...

455

Conserved Gene / Pathway

Phase 2: March 2008

3GSE

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00580
(show subtarget assignments)

1

soluble

YPO0059

16120412

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

403

Conserved Gene / Pathway

Phase 2: March 2008

1FC4

82.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01850
(show subtarget assignments)

1

cloned

FTT0916c

56708017

ribF

riboflavin biosynthesis protein RibF [Fr...

306

Drug Target

Phase 3: June 2008

1MRZ

30.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01079
(show subtarget assignments)

0

work_stopped

STM4167

16767421

hemE

uroporphyrinogen decarboxylase

354

Essential Gene

Phase 2: March 2008

3CYV

96%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01436
(show subtarget assignments)

1

crystallized

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02227
(show subtarget assignments)

1

cloned

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02242
(show subtarget assignments)

1

cloned

Cj0320

15791688

fliH

flagellar assembly protein H [Campylobac...

276

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01069
(show subtarget assignments)

1

soluble

STM3938

16767209

hemC

porphobilinogen deaminase

318

Conserved Gene / Pathway

Phase 2: March 2008

1AH5

87.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01958
(show subtarget assignments)

1

expressed

FTT0937c

56708034

bioB

biotin synthase [Francisella tularensis ...

313

Drug Target

Phase 3: June 2008

1R30

49.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01063
(show subtarget assignments)

1

soluble

STM3702

16766987

grxC

glutaredoxin 3

83

Conserved Gene / Pathway

Phase 2: March 2008

1FOV

86.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP00559
(show subtarget assignments)

1

purified

YPO3032

16123209

hemF

coproporphyrinogen III oxidase

309

Conserved Gene / Pathway

Phase 2: March 2008

3E8J

59.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01059
(show subtarget assignments)

1

soluble

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02257
(show subtarget assignments)

1

expressed

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02217
(show subtarget assignments)

1

expressed

FTT1018c

56708107

dxs

1-deoxy-D-xylulose-5-phosphate synthase ...

615

Conserved; Drug target functions

Phase 3: June 2008

2O1S

56.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

OtherPyridoxine,Thiamine

IDP02423
(show subtarget assignments)

1

cloned

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02213
(show subtarget assignments)

1

expressed

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00555
(show subtarget assignments)

1

purified

YPO3424

16123573

nadC

quinolinate phosphoribosyltransferase

302

Conserved Gene / Pathway

Phase 2: March 2008

1QAP

72.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01753
(show subtarget assignments)

1

expressed

CBU_0423

29541032

panC

pantoate--beta-alanine ligase [Coxiella ...

257

Conserved; Drug target functions

Phase 3: June 2008

3N8H

40.9%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02218
(show subtarget assignments)

1

expressed

GBAA2133

47778008

narA-1

molybdenum cofactor biosynthesis protein...

337

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TV7

54.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02416
(show subtarget assignments)

1

purified

FTT1259

56708321

nadE

NH(3)-dependent NAD(+) synthetase [Franc...

249

Conserved; Drug target functions

Phase 3: June 2008

3FIU

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02424
(show subtarget assignments)

1

cloned

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01044
(show subtarget assignments)

1

soluble

STM3070

16766371

epd

D-erythrose 4-phosphate dehydrogenase

348

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

91.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine