Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00304 (show subtarget assignments)	1	purified	CBU_0038	29653401		3-oxoacyl-(acyl-carrier-protein) synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	29.6%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02778 (show subtarget assignments)	1	cloned	CBU_0056	29540679		outer membrane protein TolC, putative [C...	616	Conserved; Drug target functions	Phase 3: June 2008	2VDD	27.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01931 (show subtarget assignments)	1	soluble	CBU_0073	29540696		peptidase, M24 family protein [Coxiella ...	597	Conserved; Drug target functions	Phase 3: June 2008	3CTZ	40.6%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91580 (show subtarget assignments)	8	cloned	CBU_0077	29540700		hypothetical protein	263	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91581 (show subtarget assignments)	8	cloned	CBU_0080	29540703		hypothetical protein	160	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP02122 (show subtarget assignments)	1	cloned	CBU_0090	29540712	tolB	tolB protein [Coxiella burnetii RSA 493]...	437	Conserved; Drug target functions	Phase 3: June 2008	1C5K	40.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP02116 (show subtarget assignments)	1	soluble	CBU_0094	29540716	clpB	clpB protein [Coxiella burnetii RSA 493]...	859	Conserved; Drug target functions	Phase 3: June 2008	1QVR	58.2%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02607 (show subtarget assignments)	1	expressed	CBU_0101	29540723	nadB	L-aspartate oxidase [Coxiella burnetii R...	536	Conserved; Drug target functions	Phase 3: June 2008	1CHU	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02015 (show subtarget assignments)	1	expressed	CBU_0107	29540727		ABC transporter, ATP-binding protein [Co...	351	Conserved; Drug target functions	Phase 3: June 2008	3DHW	49.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02622 (show subtarget assignments)	1	cloned	CBU_0109	29540729		ABC transporter, periplasmic substrate-b...	267	Conserved; Drug target functions	Phase 3: June 2008	3TQW	88.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02514 (show subtarget assignments)	1	purified	CBU_0116	29540736	mraW	S-adenosyl-methyltransferase MraW [Coxie...	307	Conserved; Drug target functions	Phase 3: June 2008	1WG8	46.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP00305 (show subtarget assignments)	1	cloned	CBU_0118	29653476	pbpB	penicillin-binding protein 3	548	Drug Target Function	Phase 2: March 2008	3OC2	45.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02026 (show subtarget assignments)	1	purified	CBU_0123	29540743	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2...	489	Conserved; Drug target functions	Phase 3: June 2008	1E8C	41.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02731 (show subtarget assignments)	1	expressed	CBU_0124	29540744	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	446	Conserved; Drug target functions	Phase 3: June 2008	1GG4	43.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02024 (show subtarget assignments)	1	expressed	CBU_0131	29540751	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	442	Conserved; Drug target functions	Phase 3: June 2008	1E0D	43%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02037 (show subtarget assignments)	1	cloned	CBU_0135	29540755	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	358	Conserved; Drug target functions	Phase 3: June 2008	1F0K	46.6%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01935 (show subtarget assignments)	1	expressed	CBU_0136	29540756	murC	UDP-N-acetylmuramate--alanine ligase [Co...	465	Conserved; Drug target functions	Phase 3: June 2008	2F00	47.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00306 (show subtarget assignments)	1	expressed	CBU_0137	29653495	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	316	Drug Target Function	Phase 2: March 2008	3TX1	34.8%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02788 (show subtarget assignments)	1	expressed	CBU_0140	29540760	ftsA	cell division protein FtsA [Coxiella bur...	410	Conserved; Drug target functions	Phase 3: June 2008	1E4F	22.9%	Coxiella burnetii	Cellular processes	Cell division

IDP02789 (show subtarget assignments)	1	cloned	CBU_0141	29540761	ftsZ	cell division protein FtsZ [Coxiella bur...	386	Conserved; Drug target functions	Phase 3: June 2008	2VAW	63.4%	Coxiella burnetii	Cellular processes	Cell division

IDP00307 (show subtarget assignments)	1	expressed	CBU_0142	29653500	lpxC	UDP-3-0-acyl N-acetylglucosamine deacety...	303	Drug Target Function	Phase 2: March 2008	2VES	65.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02061 (show subtarget assignments)	1	cloned	CBU_0147	29540767	secA	preprotein translocase, SecA subunit [Co...	913	Conserved; Drug target functions	Phase 3: June 2008	2FSF	59.9%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP04629 (show subtarget assignments)	1	soluble	CBU_0151	29653509	queF	7-cyano-7-deazaguanine reductase [Coxiel...	278	drug target; conserved gene;	Phase 4: April 2009	3BP1	51.4%	Coxiella burnetii	Hypothetical proteins	Conserved

IDP01835 (show subtarget assignments)	1	cloned	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02608 (show subtarget assignments)	1	expressed	CBU_0178	29540794		ABC transporter, ATP-binding protein [Co...	252	Conserved; Drug target functions	Phase 3: June 2008	1V43	43.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02543 (show subtarget assignments)	1	expressed	CBU_0275	29540889	hemE	uroporphyrinogen decarboxylase [Coxiella...	361	Conserved; Drug target functions	Phase 3: June 2008	3CYV	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00308 (show subtarget assignments)	1	soluble	CBU_0288	29653640	coaD	phosphopantetheine adenylyltransferase	159	Drug Target Function	Phase 2: March 2008	3IKZ	47.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91582 (show subtarget assignments)	8	cloned	CBU_0295	29540908		hypothetical protein	489	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP00309 (show subtarget assignments)	1	expressed	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01638 (show subtarget assignments)	1	soluble	CBU_0312	29540925	folD	folD bifunctional protein [Coxiella burn...	283	Conserved; Drug target functions	Phase 3: June 2008	1B0A	59.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01777 (show subtarget assignments)	1	cloned	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91583 (show subtarget assignments)	8	expressed	CBU_0329	29540941		hypothetical protein	198	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01779 (show subtarget assignments)	1	soluble	CBU_0366	29540977	phoR	sensor histidine kinase PhoR protein, pu...	252	Conserved; Drug target functions	Phase 3: June 2008	2C2A	31.3%	Coxiella burnetii	Signal transduction	Two-component systems

IDP02823 (show subtarget assignments)	1	soluble	CBU_0382	29540992	ispB	octylprenyl diphosphate synthase-like pr...	332	Conserved; Drug target functions	Phase 3: June 2008	3MZV	44%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02063 (show subtarget assignments)	1	purified	CBU_0387	29540997	cgtA	GTP-binding protein, GTP1/Obg family [Co...	339	Conserved; Drug target functions	Phase 3: June 2008	1UDX	46.3%	Coxiella burnetii	Unknown function	General

IDP02555 (show subtarget assignments)	1	expressed	CBU_0391	29541001	ribF	riboflavin biosynthesis protein RibF [Co...	320	Conserved; Drug target functions	Phase 3: June 2008	1MRZ	33.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02073 (show subtarget assignments)	1	expressed	CBU_0418	29541027		4-amino-4-deoxychorismate lyase, putativ...	281	Conserved; Drug target functions	Phase 3: June 2008	3LUL	28.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01753 (show subtarget assignments)	1	expressed	CBU_0423	29541032	panC	pantoate--beta-alanine ligase [Coxiella ...	257	Conserved; Drug target functions	Phase 3: June 2008	3N8H	40.9%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02089 (show subtarget assignments)	1	cloned	CBU_0424	29541033	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Conserved; Drug target functions	Phase 3: June 2008	1OY0	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91584 (show subtarget assignments)	8	expressed	CBU_0425	29541034		hypothetical protein	455	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP02129 (show subtarget assignments)	1	expressed	CBU_0450	29541057	ffh	signal recognition particle protein [Cox...	461	Conserved; Drug target functions	Phase 3: June 2008	2XXA	57.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP91097 (show subtarget assignments)	8	cloned	CBU_0479	29541085	kdsB	3-deoxy-D-manno-octulosonate cytidylyltr...	253	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	3TQD	100%	Coxiella burnetii

IDP01641 (show subtarget assignments)	1	cloned	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	Phase 3: June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP02749 (show subtarget assignments)	1	soluble	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP00310 (show subtarget assignments)	1	expressed	CBU_0493	29653835	fabH	3-oxoacyl-(acyl-carrier-protein) synthas...	319	Drug Target Function	Phase 2: March 2008	1HN9	54.4%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00311 (show subtarget assignments)	1	soluble	CBU_0494	29653836	fabD	malonyl CoA-acyl carrier protein transac...	313	Drug Target Function	Phase 2: March 2008	3TQE	100%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00312 (show subtarget assignments)	1	expressed	CBU_0497	29653839	fabF	3-oxoacyl-acyl carrier protein synthase ...	414	Drug Target Function	Phase 2: March 2008	1B3N	60.1%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01786 (show subtarget assignments)	1	expressed	CBU_0502	29541107		hydrolase, putative [Coxiella burnetii R...	225	Conserved; Drug target functions	Phase 3: June 2008	2GZX	44.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02102 (show subtarget assignments)	1	cloned	CBU_0503	29541108	glnA	glutamine synthetase [Coxiella burnetii ...	359	Conserved; Drug target functions	Phase 3: June 2008	3FKY	49.9%	Coxiella burnetii	Amino acid biosynthesis	Glutamate family

IDP02483 (show subtarget assignments)	1	cloned	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02764 (show subtarget assignments)	1	expressed	CBU_0525	29541128	serC	phosphoserine aminotransferase [Coxiella...	360	Conserved; Drug target functions	Phase 3: June 2008	3QBO	53.6%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP01842 (show subtarget assignments)	1	in_pdb 3ROI 3SLH	CBU_0526	29541129	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	438	Conserved; Drug target functions	Phase 3: June 2008	3ROI	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00320 (show subtarget assignments)	1	expressed	CBU_0550	29653890	pbpA	penicillin-binding protein 2	612	Drug Target Function	Phase 2: March 2008	1MWR	25.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01960 (show subtarget assignments)	1	soluble	CBU_0565	29541166		CBS domain protein [Coxiella burnetii RS...	279	Conserved; Drug target functions	Phase 3: June 2008	3LFR	27.2%	Coxiella burnetii	Unknown function	General

IDP01962 (show subtarget assignments)	1	in_pdb 3IJ3	CBU_0572	29541173		cytosol aminopeptidase family protein [C...	458	Conserved; Drug target functions	Phase 3: June 2008	3IJ3	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02134 (show subtarget assignments)	1	soluble	CBU_0597	29541198		oxygen-independent coproporphyrinogen II...	375	Conserved; Drug target functions	Phase 3: June 2008	1OLT	20.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02027 (show subtarget assignments)	1	soluble	CBU_0599	29541200	cysQ-1	3'(2'),5'-bisphosphate nucleotidase [Cox...	271	Conserved; Drug target functions	Phase 3: June 2008	3B8B	39.5%	Coxiella burnetii	Central intermediary metabolism	Sulfur metabolism

IDP04341 (show subtarget assignments)	1	expressed	CBU_0634	215919011		putative aerobic respiration control sen...	630	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	14.8%	Coxiella burnetii	Regulatory functions	Protein interactions

IDP91585 (show subtarget assignments)	8	cloned	CBU_0635	29541236		hypothetical protein	496	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01615 (show subtarget assignments)	1	purified	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	Phase 3: June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01803 (show subtarget assignments)	1	soluble	CBU_0646	29541247	ribE	riboflavin synthase, alpha subunit [Coxi...	202	Conserved; Drug target functions	Phase 3: June 2008	1I8D	37.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00313 (show subtarget assignments)	1	expressed	CBU_0647	29653985	ribA	riboflavin biosynthesis protein RibA	406	Drug Target Function	Phase 2: March 2008	2BZ0	27.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02565 (show subtarget assignments)	1	soluble	CBU_0648	29541249	ribH	6,7-dimethyl-8-ribityllumazine synthase ...	151	Conserved; Drug target functions	Phase 3: June 2008	1VSW	47.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90357 (show subtarget assignments)	8	selected	CBU_0666	29654004	dapE	succinyl-diaminopimelate desuccinylase [...	374	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3IC1	50.5%	Coxiella burnetii

IDP01785 (show subtarget assignments)	1	expressed	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01604 (show subtarget assignments)	1	purified	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	1Z47	24.4%	Coxiella burnetii	Transport and binding proteins	Other

IDP01758 (show subtarget assignments)	1	expressed	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02141 (show subtarget assignments)	1	purified	CBU_0737	29541337	tig	trigger factor [Coxiella burnetii RSA 49...	442	Conserved; Drug target functions	Phase 3: June 2008	1W26	41%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02028 (show subtarget assignments)	1	in_pdb 3Q7H	CBU_0738	29541338	clpP	ATP-dependent Clp protease, proteolytic ...	195	Conserved; Drug target functions	Phase 3: June 2008	3Q7H	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02143 (show subtarget assignments)	1	expressed	CBU_0739	29541339	clpX	ATP-dependent Clp protease, ATP-binding ...	422	Conserved; Drug target functions	Phase 3: June 2008	3HTE	59.5%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02552 (show subtarget assignments)	1	expressed	CBU_0743	29541343	ptsH	phosphocarrier protein HPr [Coxiella bur...	89	Conserved; Drug target functions	Phase 3: June 2008	3LE1	46.1%	Coxiella burnetii	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01998 (show subtarget assignments)	1	cloned	CBU_0744	29541344		Hpr(Ser) kinase/phosphatase [Coxiella bu...	192	Conserved; Drug target functions	Phase 3: June 2008	3TQF	92.7%	Coxiella burnetii	Signal transduction	PTS

IDP01601 (show subtarget assignments)	1	expressed	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP91086 (show subtarget assignments)	8	expressed	CBU_0750	29541350		KpsF/GutQ family protein	324	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	33.3%	Coxiella burnetii	Unknown function: General

IDP00314 (show subtarget assignments)	1	expressed	CBU_0751	29654085	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Function	Phase 2: March 2008	1EJC	57.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02142 (show subtarget assignments)	1	cloned	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP01660 (show subtarget assignments)	1	expressed	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04733 (show subtarget assignments)	1	cloned	CBU_0789	215919045		two component system histidine kinase [C...	831	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10.5%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01647 (show subtarget assignments)	1	expressed	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	Phase 3: June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01649 (show subtarget assignments)	1	expressed	CBU_0796	29541390		HIT family protein [Coxiella burnetii RS...	113	Conserved; Drug target functions	Phase 3: June 2008	1AV5	49.6%	Coxiella burnetii	Unknown function	General

IDP01910 (show subtarget assignments)	1	expressed	CBU_0798	29541392		multidrug resistance protein [Coxiella b...	331	Conserved; Drug target functions	Phase 3: June 2008	3FPP	19.3%	Coxiella burnetii	Transport and binding proteins	Other

IDP01754 (show subtarget assignments)	1	expressed	CBU_0803	29541397		efflux transporter, RND family, MFP subu...	351	Conserved; Drug target functions	Phase 3: June 2008	1T5E	27.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP01984 (show subtarget assignments)	1	expressed	CBU_0831	29541425	asnB-1	asparagine synthetase B, glutamine-hydro...	632	Conserved; Drug target functions	Phase 3: June 2008	1CT9	18.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01728 (show subtarget assignments)	1	expressed	CBU_0840	29541434	asnB-2	asparagine synthetase B, glutamine-hydro...	637	Conserved; Drug target functions	Phase 3: June 2008	1Q15	13%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01972 (show subtarget assignments)	1	cloned	CBU_0841	29541435		glycosyl transferase, group 1 family pro...	377	Conserved; Drug target functions	Phase 3: June 2008	2GEJ	24.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91078 (show subtarget assignments)	8	cloned	CBU_0856	29541449		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5X	42.3%	Coxiella burnetii

IDP01676 (show subtarget assignments)	1	cloned	CBU_0869	29541462	alr	alanine racemase [Coxiella burnetii RSA ...	364	Conserved; Drug target functions	Phase 3: June 2008	2RJG	42.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00315 (show subtarget assignments)	1	purified	CBU_0874	29654200	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1R52	44.7%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02042 (show subtarget assignments)	1	cloned	CBU_0875	29541467	asd	aspartate-semialdehyde dehydrogenase [Co...	340	Conserved; Drug target functions	Phase 3: June 2008	2QZ9	61.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02153 (show subtarget assignments)	1	expressed	CBU_0884	29541475	bipA	virulence regulator BipA [Coxiella burne...	602	Conserved; Drug target functions	Phase 3: June 2008	3E3X	34.6%	Coxiella burnetii	Cellular processes	Pathogenesis

IDP02167 (show subtarget assignments)	1	expressed	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02171 (show subtarget assignments)	1	soluble	CBU_0894	29541483	folC	FolC bifunctional protein [Coxiella burn...	416	Conserved; Drug target functions	Phase 3: June 2008	1W78	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02056 (show subtarget assignments)	1	expressed	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00301 (show subtarget assignments)	1	expressed	CBU_0983				291	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 2: March 2008	3NVT	10.7%	Coxiella burnetii

IDP01858 (show subtarget assignments)	1	cloned	CBU_0993	29541575	def	peptide deformylase [Coxiella burnetii R...	170	Conserved; Drug target functions	Phase 3: June 2008	1N5N	47.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP02176 (show subtarget assignments)	1	purified	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP02629 (show subtarget assignments)	1	purified	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02046 (show subtarget assignments)	1	soluble	CBU_1007	29541589	bioB	biotin synthase [Coxiella burnetii RSA 4...	321	Conserved; Drug target functions	Phase 3: June 2008	1R30	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01797 (show subtarget assignments)	1	cloned	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02060 (show subtarget assignments)	1	expressed	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00304
(show subtarget assignments)

1

purified

CBU_0038

29653401

3-oxoacyl-(acyl-carrier-protein) synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

29.6%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02778
(show subtarget assignments)

1

cloned

CBU_0056

29540679

outer membrane protein TolC, putative [C...

616

Conserved; Drug target functions

Phase 3: June 2008

2VDD

27.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01931
(show subtarget assignments)

1

soluble

CBU_0073

29540696

peptidase, M24 family protein [Coxiella ...

597

Conserved; Drug target functions

Phase 3: June 2008

3CTZ

40.6%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91580
(show subtarget assignments)

8

cloned

CBU_0077

29540700

hypothetical protein

263

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91581
(show subtarget assignments)

8

cloned

CBU_0080

29540703

hypothetical protein

160

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP02122
(show subtarget assignments)

1

cloned

CBU_0090

29540712

tolB

tolB protein [Coxiella burnetii RSA 493]...

437

Conserved; Drug target functions

Phase 3: June 2008

1C5K

40.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP02116
(show subtarget assignments)

1

soluble

CBU_0094

29540716

clpB

clpB protein [Coxiella burnetii RSA 493]...

859

Conserved; Drug target functions

Phase 3: June 2008

1QVR

58.2%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02607
(show subtarget assignments)

1

expressed

CBU_0101

29540723

nadB

L-aspartate oxidase [Coxiella burnetii R...

536

Conserved; Drug target functions

Phase 3: June 2008

1CHU

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02015
(show subtarget assignments)

1

expressed

CBU_0107

29540727

ABC transporter, ATP-binding protein [Co...

351

Conserved; Drug target functions

Phase 3: June 2008

3DHW

49.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02622
(show subtarget assignments)

1

cloned

CBU_0109

29540729

ABC transporter, periplasmic substrate-b...

267

Conserved; Drug target functions

Phase 3: June 2008

3TQW

88.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02514
(show subtarget assignments)

1

purified

CBU_0116

29540736

mraW

S-adenosyl-methyltransferase MraW [Coxie...

307

Conserved; Drug target functions

Phase 3: June 2008

1WG8

46.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP00305
(show subtarget assignments)

1

cloned

CBU_0118

29653476

pbpB

penicillin-binding protein 3

548

Drug Target Function

Phase 2: March 2008

3OC2

45.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02026
(show subtarget assignments)

1

purified

CBU_0123

29540743

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2...

489

Conserved; Drug target functions

Phase 3: June 2008

1E8C

41.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02731
(show subtarget assignments)

1

expressed

CBU_0124

29540744

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

446

Conserved; Drug target functions

Phase 3: June 2008

1GG4

43.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02024
(show subtarget assignments)

1

expressed

CBU_0131

29540751

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

442

Conserved; Drug target functions

Phase 3: June 2008

1E0D

43%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02037
(show subtarget assignments)

1

cloned

CBU_0135

29540755

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

358

Conserved; Drug target functions

Phase 3: June 2008

1F0K

46.6%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01935
(show subtarget assignments)

1

expressed

CBU_0136

29540756

murC

UDP-N-acetylmuramate--alanine ligase [Co...

465

Conserved; Drug target functions

Phase 3: June 2008

2F00

47.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00306
(show subtarget assignments)

1

expressed

CBU_0137

29653495

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

316

Drug Target Function

Phase 2: March 2008

3TX1

34.8%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02788
(show subtarget assignments)

1

expressed

CBU_0140

29540760

ftsA

cell division protein FtsA [Coxiella bur...

410

Conserved; Drug target functions

Phase 3: June 2008

1E4F

22.9%

Coxiella burnetii

Cellular processes

Cell division

IDP02789
(show subtarget assignments)

1

cloned

CBU_0141

29540761

ftsZ

cell division protein FtsZ [Coxiella bur...

386

Conserved; Drug target functions

Phase 3: June 2008

2VAW

63.4%

Coxiella burnetii

Cellular processes

Cell division

IDP00307
(show subtarget assignments)

1

expressed

CBU_0142

29653500

lpxC

UDP-3-0-acyl N-acetylglucosamine deacety...

303

Drug Target Function

Phase 2: March 2008

2VES

65.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02061
(show subtarget assignments)

1

cloned

CBU_0147

29540767

secA

preprotein translocase, SecA subunit [Co...

913

Conserved; Drug target functions

Phase 3: June 2008

2FSF

59.9%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP04629
(show subtarget assignments)

1

soluble

CBU_0151

29653509

queF

7-cyano-7-deazaguanine reductase [Coxiel...

278

drug target; conserved gene;

Phase 4: April 2009

3BP1

51.4%

Coxiella burnetii

Hypothetical proteins

Conserved

IDP01835
(show subtarget assignments)

1

cloned

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02608
(show subtarget assignments)

1

expressed

CBU_0178

29540794

ABC transporter, ATP-binding protein [Co...

252

Conserved; Drug target functions

Phase 3: June 2008

1V43

43.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02543
(show subtarget assignments)

1

expressed

CBU_0275

29540889

hemE

uroporphyrinogen decarboxylase [Coxiella...

361

Conserved; Drug target functions

Phase 3: June 2008

3CYV

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00308
(show subtarget assignments)

1

soluble

CBU_0288

29653640

coaD

phosphopantetheine adenylyltransferase

159

Drug Target Function

Phase 2: March 2008

3IKZ

47.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91582
(show subtarget assignments)

8

cloned

CBU_0295

29540908

hypothetical protein

489

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP00309
(show subtarget assignments)

1

expressed

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01638
(show subtarget assignments)

1

soluble

CBU_0312

29540925

folD

folD bifunctional protein [Coxiella burn...

283

Conserved; Drug target functions

Phase 3: June 2008

1B0A

59.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01777
(show subtarget assignments)

1

cloned

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91583
(show subtarget assignments)

8

expressed

CBU_0329

29540941

hypothetical protein

198

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01779
(show subtarget assignments)

1

soluble

CBU_0366

29540977

phoR

sensor histidine kinase PhoR protein, pu...

252

Conserved; Drug target functions

Phase 3: June 2008

2C2A

31.3%

Coxiella burnetii

Signal transduction

Two-component systems

IDP02823
(show subtarget assignments)

1

soluble

CBU_0382

29540992

ispB

octylprenyl diphosphate synthase-like pr...

332

Conserved; Drug target functions

Phase 3: June 2008

3MZV

44%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02063
(show subtarget assignments)

1

purified

CBU_0387

29540997

cgtA

GTP-binding protein, GTP1/Obg family [Co...

339

Conserved; Drug target functions

Phase 3: June 2008

1UDX

46.3%

Coxiella burnetii

Unknown function

General

IDP02555
(show subtarget assignments)

1

expressed

CBU_0391

29541001

ribF

riboflavin biosynthesis protein RibF [Co...

320

Conserved; Drug target functions

Phase 3: June 2008

1MRZ

33.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02073
(show subtarget assignments)

1

expressed

CBU_0418

29541027

4-amino-4-deoxychorismate lyase, putativ...

281

Conserved; Drug target functions

Phase 3: June 2008

3LUL

28.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01753
(show subtarget assignments)

1

expressed

CBU_0423

29541032

panC

pantoate--beta-alanine ligase [Coxiella ...

257

Conserved; Drug target functions

Phase 3: June 2008

3N8H

40.9%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02089
(show subtarget assignments)

1

cloned

CBU_0424

29541033

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Conserved; Drug target functions

Phase 3: June 2008

1OY0

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91584
(show subtarget assignments)

8

expressed

CBU_0425

29541034

hypothetical protein

455

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP02129
(show subtarget assignments)

1

expressed

CBU_0450

29541057

ffh

signal recognition particle protein [Cox...

461

Conserved; Drug target functions

Phase 3: June 2008

2XXA

57.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP91097
(show subtarget assignments)

8

cloned

CBU_0479

29541085

kdsB

3-deoxy-D-manno-octulosonate cytidylyltr...

253

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

3TQD

100%

Coxiella burnetii

IDP01641
(show subtarget assignments)

1

cloned

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

Phase 3: June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP02749
(show subtarget assignments)

1

soluble

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP00310
(show subtarget assignments)

1

expressed

CBU_0493

29653835

fabH

3-oxoacyl-(acyl-carrier-protein) synthas...

319

Drug Target Function

Phase 2: March 2008

1HN9

54.4%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00311
(show subtarget assignments)

1

soluble

CBU_0494

29653836

fabD

malonyl CoA-acyl carrier protein transac...

313

Drug Target Function

Phase 2: March 2008

3TQE

100%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00312
(show subtarget assignments)

1

expressed

CBU_0497

29653839

fabF

3-oxoacyl-acyl carrier protein synthase ...

414

Drug Target Function

Phase 2: March 2008

1B3N

60.1%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01786
(show subtarget assignments)

1

expressed

CBU_0502

29541107

hydrolase, putative [Coxiella burnetii R...

225

Conserved; Drug target functions

Phase 3: June 2008

2GZX

44.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02102
(show subtarget assignments)

1

cloned

CBU_0503

29541108

glnA

glutamine synthetase [Coxiella burnetii ...

359

Conserved; Drug target functions

Phase 3: June 2008

3FKY

49.9%

Coxiella burnetii

Amino acid biosynthesis

Glutamate family

IDP02483
(show subtarget assignments)

1

cloned

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02764
(show subtarget assignments)

1

expressed

CBU_0525

29541128

serC

phosphoserine aminotransferase [Coxiella...

360

Conserved; Drug target functions

Phase 3: June 2008

3QBO

53.6%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP01842
(show subtarget assignments)

1

in_pdb
3ROI
3SLH

CBU_0526

29541129

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

438

Conserved; Drug target functions

Phase 3: June 2008

3ROI

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00320
(show subtarget assignments)

1

expressed

CBU_0550

29653890

pbpA

penicillin-binding protein 2

612

Drug Target Function

Phase 2: March 2008

1MWR

25.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01960
(show subtarget assignments)

1

soluble

CBU_0565

29541166

CBS domain protein [Coxiella burnetii RS...

279

Conserved; Drug target functions

Phase 3: June 2008

3LFR

27.2%

Coxiella burnetii

Unknown function

General

IDP01962
(show subtarget assignments)

1

in_pdb
3IJ3

CBU_0572

29541173

cytosol aminopeptidase family protein [C...

458

Conserved; Drug target functions

Phase 3: June 2008

3IJ3

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02134
(show subtarget assignments)

1

soluble

CBU_0597

29541198

oxygen-independent coproporphyrinogen II...

375

Conserved; Drug target functions

Phase 3: June 2008

1OLT

20.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02027
(show subtarget assignments)

1

soluble

CBU_0599

29541200

cysQ-1

3'(2'),5'-bisphosphate nucleotidase [Cox...

271

Conserved; Drug target functions

Phase 3: June 2008

3B8B

39.5%

Coxiella burnetii

Central intermediary metabolism

Sulfur metabolism

IDP04341
(show subtarget assignments)

1

expressed

CBU_0634

215919011

putative aerobic respiration control sen...

630

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

14.8%

Coxiella burnetii

Regulatory functions

Protein interactions

IDP91585
(show subtarget assignments)

8

cloned

CBU_0635

29541236

hypothetical protein

496

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01615
(show subtarget assignments)

1

purified

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

Phase 3: June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01803
(show subtarget assignments)

1

soluble

CBU_0646

29541247

ribE

riboflavin synthase, alpha subunit [Coxi...

202

Conserved; Drug target functions

Phase 3: June 2008

1I8D

37.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00313
(show subtarget assignments)

1

expressed

CBU_0647

29653985

ribA

riboflavin biosynthesis protein RibA

406

Drug Target Function

Phase 2: March 2008

2BZ0

27.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02565
(show subtarget assignments)

1

soluble

CBU_0648

29541249

ribH

6,7-dimethyl-8-ribityllumazine synthase ...

151

Conserved; Drug target functions

Phase 3: June 2008

1VSW

47.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90357
(show subtarget assignments)

8

selected

CBU_0666

29654004

dapE

succinyl-diaminopimelate desuccinylase [...

374

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3IC1

50.5%

Coxiella burnetii

IDP01785
(show subtarget assignments)

1

expressed

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01604
(show subtarget assignments)

1

purified

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

1Z47

24.4%

Coxiella burnetii

Transport and binding proteins

Other

IDP01758
(show subtarget assignments)

1

expressed

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02141
(show subtarget assignments)

1

purified

CBU_0737

29541337

tig

trigger factor [Coxiella burnetii RSA 49...

442

Conserved; Drug target functions

Phase 3: June 2008

1W26

41%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02028
(show subtarget assignments)

1

in_pdb
3Q7H

CBU_0738

29541338

clpP

ATP-dependent Clp protease, proteolytic ...

195

Conserved; Drug target functions

Phase 3: June 2008

3Q7H

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02143
(show subtarget assignments)

1

expressed

CBU_0739

29541339

clpX

ATP-dependent Clp protease, ATP-binding ...

422

Conserved; Drug target functions

Phase 3: June 2008

3HTE

59.5%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02552
(show subtarget assignments)

1

expressed

CBU_0743

29541343

ptsH

phosphocarrier protein HPr [Coxiella bur...

89

Conserved; Drug target functions

Phase 3: June 2008

3LE1

46.1%

Coxiella burnetii

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01998
(show subtarget assignments)

1

cloned

CBU_0744

29541344

Hpr(Ser) kinase/phosphatase [Coxiella bu...

192

Conserved; Drug target functions

Phase 3: June 2008

3TQF

92.7%

Coxiella burnetii

Signal transduction

PTS

IDP01601
(show subtarget assignments)

1

expressed

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP91086
(show subtarget assignments)

8

expressed

CBU_0750

29541350

KpsF/GutQ family protein

324

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

33.3%

Coxiella burnetii

Unknown function: General

IDP00314
(show subtarget assignments)

1

expressed

CBU_0751

29654085

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Function

Phase 2: March 2008

1EJC

57.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02142
(show subtarget assignments)

1

cloned

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP01660
(show subtarget assignments)

1

expressed

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04733
(show subtarget assignments)

1

cloned

CBU_0789

215919045

two component system histidine kinase [C...

831

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10.5%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01647
(show subtarget assignments)

1

expressed

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

Phase 3: June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01649
(show subtarget assignments)

1

expressed

CBU_0796

29541390

HIT family protein [Coxiella burnetii RS...

113

Conserved; Drug target functions

Phase 3: June 2008

1AV5

49.6%

Coxiella burnetii

Unknown function

General

IDP01910
(show subtarget assignments)

1

expressed

CBU_0798

29541392

multidrug resistance protein [Coxiella b...

331

Conserved; Drug target functions

Phase 3: June 2008

3FPP

19.3%

Coxiella burnetii

Transport and binding proteins

Other

IDP01754
(show subtarget assignments)

1

expressed

CBU_0803

29541397

efflux transporter, RND family, MFP subu...

351

Conserved; Drug target functions

Phase 3: June 2008

1T5E

27.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP01984
(show subtarget assignments)

1

expressed

CBU_0831

29541425

asnB-1

asparagine synthetase B, glutamine-hydro...

632

Conserved; Drug target functions

Phase 3: June 2008

1CT9

18.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01728
(show subtarget assignments)

1

expressed

CBU_0840

29541434

asnB-2

asparagine synthetase B, glutamine-hydro...

637

Conserved; Drug target functions

Phase 3: June 2008

1Q15

13%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01972
(show subtarget assignments)

1

cloned

CBU_0841

29541435

glycosyl transferase, group 1 family pro...

377

Conserved; Drug target functions

Phase 3: June 2008

2GEJ

24.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91078
(show subtarget assignments)

8

cloned

CBU_0856

29541449

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5X

42.3%

Coxiella burnetii

IDP01676
(show subtarget assignments)

1

cloned

CBU_0869

29541462

alr

alanine racemase [Coxiella burnetii RSA ...

364

Conserved; Drug target functions

Phase 3: June 2008

2RJG

42.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00315
(show subtarget assignments)

1

purified

CBU_0874

29654200

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1R52

44.7%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02042
(show subtarget assignments)

1

cloned

CBU_0875

29541467

asd

aspartate-semialdehyde dehydrogenase [Co...

340

Conserved; Drug target functions

Phase 3: June 2008

2QZ9

61.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02153
(show subtarget assignments)

1

expressed

CBU_0884

29541475

bipA

virulence regulator BipA [Coxiella burne...

602

Conserved; Drug target functions

Phase 3: June 2008

3E3X

34.6%

Coxiella burnetii

Cellular processes

Pathogenesis

IDP02167
(show subtarget assignments)

1

expressed

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02171
(show subtarget assignments)

1

soluble

CBU_0894

29541483

folC

FolC bifunctional protein [Coxiella burn...

416

Conserved; Drug target functions

Phase 3: June 2008

1W78

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02056
(show subtarget assignments)

1

expressed

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00301
(show subtarget assignments)

1

expressed

CBU_0983

291

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 2: March 2008

3NVT

10.7%

Coxiella burnetii

IDP01858
(show subtarget assignments)

1

cloned

CBU_0993

29541575

def

peptide deformylase [Coxiella burnetii R...

170

Conserved; Drug target functions

Phase 3: June 2008

1N5N

47.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP02176
(show subtarget assignments)

1

purified

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP02629
(show subtarget assignments)

1

purified

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02046
(show subtarget assignments)

1

soluble

CBU_1007

29541589

bioB

biotin synthase [Coxiella burnetii RSA 4...

321

Conserved; Drug target functions

Phase 3: June 2008

1R30

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01797
(show subtarget assignments)

1

cloned

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02060
(show subtarget assignments)

1

expressed

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

Targets