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Targets
Filter Targets:
Selection Phase:
No Filter
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM 10
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
Clostridium difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
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cloned
crystallized
crystal_structure
diffraction
expressed
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
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CSGID ID
Priority
stage
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP01470
(
show subtarget assignments
)
1
soluble
VC2608
15642603
ABC transporter, ATP-binding protein
664
Conserved Gene / Pathway
Phase 2: March 2008
2IW3
23.8%
Vibrio cholerae
Transport and binding proteins
Unknown substrate
IDP01471
(
show subtarget assignments
)
1
soluble
VC2613
15642608
phosphoribulokinase
289
Conserved Gene / Pathway
Phase 2: March 2008
1A7J
51.6%
Vibrio cholerae
Energy metabolism
Sugars
IDP90665
(
show subtarget assignments
)
8
purified
VC2618
15642613
argD
bifunctional N-succinyldiaminopimelate-a...
403
Predicted Essential
Community Requests
2PB0
58.1%
Vibrio cholerae
IDP04176
(
show subtarget assignments
)
1
in_pdb
3OKF
VC2628
15642623
aroB
3-dehydroquinate synthase [Vibrio choler...
366
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3OKF
100%
Vibrio cholerae
Amino acid biosynthesis
Aromatic amino acid family
IDP01472
(
show subtarget assignments
)
1
cloned
VC2631
15642626
fimbrial assembly protein PilP, putative...
172
Conserved Gene / Pathway
Phase 2: March 2008
2LC4
16.3%
Vibrio cholerae
Cell envelope
Surface structures
IDP01323
(
show subtarget assignments
)
1
cloned
VC2633
15642628
fimbrial assembly protein PilN, putative...
196
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Cell envelope
Surface structures
IDP90691
(
show subtarget assignments
)
8
soluble
VC2643
15642638
acetylglutamate kinase [Vibrio cholerae ...
262
Predicted Essential
Community Requests
3T7B
59.5%
Vibrio cholerae
IDP90249
(
show subtarget assignments
)
8
soluble
VC2645
15642640
acetylornithine deacetylase [Vibrio chol...
378
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2F7V
26.8%
Vibrio cholerae
IDP01343
(
show subtarget assignments
)
1
cloned
VC2649
15642644
cysE
serine acetyltransferase
273
Drug Target Function
Phase 2: March 2008
1T3D
72.2%
Vibrio cholerae
Amino acid biosynthesis
Serine family
IDP01473
(
show subtarget assignments
)
1
soluble
VC2653
15642648
preprotein translocase subunit SecB
154
Conserved Gene / Pathway
Phase 2: March 2008
1QYN
66.2%
Vibrio cholerae
Protein fate
Protein and peptide secretion and trafficking
IDP01474
(
show subtarget assignments
)
1
expressed
VC2657
15642652
fumarate reductase iron-sulfur subunit
252
Conserved Gene / Pathway
Phase 2: March 2008
1KF6
69%
Vibrio cholerae
Energy metabolism
Anaerobic
IDP01475
(
show subtarget assignments
)
1
purified
VC2675
15642670
ATP-dependent protease peptidase subunit...
185
Conserved Gene / Pathway
Phase 2: March 2008
1E94
78.4%
Vibrio cholerae
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP90647
(
show subtarget assignments
)
8
cloned
VC2685
15642680
metF
5,10-methylenetetrahydrofolate reductase...
304
Predicted Essential
Community Requests
1ZP3
75.3%
Vibrio cholerae
IDP01476
(
show subtarget assignments
)
1
soluble
VC2694
15642689
superoxide dismutase, Mn
222
Conserved Gene / Pathway
Phase 2: March 2008
2RCV
48.2%
Vibrio cholerae
Cellular processes
Detoxification
IDP90535
(
show subtarget assignments
)
8
soluble
VC2695
15642690
rRNA methylase [Vibrio cholerae O1 biova...
158
Predicted Essential
Community Requests
3N4J
58.5%
Vibrio cholerae
IDP90539
(
show subtarget assignments
)
8
purified
VC2708
15642702
gmk
guanylate kinase [Vibrio cholerae O1 bio...
229
Predicted Essential
Community Requests
1S96
59.8%
Vibrio cholerae
IDP04178
(
show subtarget assignments
)
1
expressed
VC2718
15642712
bioH protein [Vibrio cholerae O1 biovar ...
268
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1M33
49.3%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP04388
(
show subtarget assignments
)
1
soluble
VC2751
15642744
adenosine deaminase [Vibrio cholerae O1 ...
334
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1A4L
32.7%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Other
IDP01477
(
show subtarget assignments
)
1
purified
VC2762
15642755
glmU
bifunctional N-acetylglucosamine-1-phosp...
453
Drug Target Function
Phase 2: March 2008
1HV9
67.5%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01478
(
show subtarget assignments
)
1
purified
VC2772
15642765
ParB family protein
293
Conserved Gene / Pathway
Phase 2: March 2008
1VZ0
33.8%
Vibrio cholerae
Cellular processes
Cell division
IDP90503
(
show subtarget assignments
)
8
purified
NP_230169
15642769
DNA primase [Vibrio cholerae O1 biovar e...
587
Predicted Essential
Community Requests
1DD9
30.8%
Vibrio cholerae
IDP00168
(
show subtarget assignments
)
1
cloned
VC2209
15642774
vibF
nonribosomal peptide synthetase VibF, au...
2413
Virulence
Phase 1: October 2007
2VSQ
10.2%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP91866
(
show subtarget assignments
)
8
selected
SPy_0037
15674279
hypothetical protein SPy_0037 [Streptoco...
303
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus pyogenes
IDP91866
(
show subtarget assignments
)
8
selected
SPy_0037
15674279
hypothetical protein SPy_0037 [Streptoco...
303
Proteins of the ComR family of Rgg regulators are important for horiz...
Community Requests
Streptococcus pyogenes
IDP90747
(
show subtarget assignments
)
8
soluble
Cj0001
15791400
dnaA
chromosomal replication initiation prote...
440
Predicted Essential
Community Requests
2Z4R
34.3%
Campylobacter jejuni
IDP02529
(
show subtarget assignments
)
1
cloned
Cj0003
15791402
gyrB
DNA gyrase subunit B [Campylobacter jeju...
769
Predicted virulence-Resistance to antibiotics and toxic compounds
Phase 3: June 2008
1EI1
27.2%
Campylobacter jejuni
Cell envelope
Other
IDP90664
(
show subtarget assignments
)
8
cloned
Cj0024
15791423
nrdA
ribonucleotide-diphosphate reductase sub...
789
Predicted Essential
Community Requests
3HNC
33.7%
Campylobacter jejuni
IDP90646
(
show subtarget assignments
)
8
in_pdb
3NXK
Cj0029
15791428
ansA
L-asparaginase [Campylobacter jejuni sub...
331
Predicted Essential
Community Requests
3NXK
100%
Campylobacter jejuni
IDP02214
(
show subtarget assignments
)
1
soluble
Cj0041
15791440
hypothetical protein Cj0041 [Campylobact...
598
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01884
(
show subtarget assignments
)
1
soluble
Cj0042
15791441
flgD
flagellar basal body rod modification pr...
294
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02266
(
show subtarget assignments
)
1
purified
Cj0043
15791442
flgE
flagellar hook protein [Campylobacter je...
545
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
3A69
25.6%
Campylobacter jejuni
Cell envelope
Surface structures
IDP02278
(
show subtarget assignments
)
1
expressed
Cj0045c
15791444
putative iron-binding protein [Campyloba...
240
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2AWC
13.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01658
(
show subtarget assignments
)
1
purified
Cj0059c
15791451
fliY
flagellar motor switch protein FliY [Cam...
280
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1O6A
15.4%
Campylobacter jejuni
Cell envelope
Other
IDP02075
(
show subtarget assignments
)
1
cloned
Cj0060c
15791452
fliM
flagellar motor switch protein FliM [Cam...
359
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
3SOH
17%
Campylobacter jejuni
Cell envelope
Surface structures
IDP02557
(
show subtarget assignments
)
1
purified
Cj0061c
15791453
fliA
flagellar biosynthesis sigma factor [Cam...
238
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1RP3
35.3%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP01890
(
show subtarget assignments
)
1
cloned
Cj0063c
15791455
ATPase, ParA family [Campylobacter jejun...
288
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1HYQ
25.7%
Campylobacter jejuni
Cell envelope
Other
IDP01664
(
show subtarget assignments
)
1
purified
Cj0064c
15791456
flhF
flagellar biosynthesis regulator FlhF [C...
484
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1ZU4
17.4%
Campylobacter jejuni
Cell envelope
Surface structures
IDP02215
(
show subtarget assignments
)
1
cloned
Cj0077c
15791467
cdtC
cytolethal distending toxin [Campylobact...
189
Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...
Phase 3: June 2008
Campylobacter jejuni
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP02292
(
show subtarget assignments
)
1
expressed
Cj0078c
15791468
cdtB
cytolethal distending toxin [Campylobact...
265
Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...
Phase 3: June 2008
1SR4
50.9%
Campylobacter jejuni
Cellular processes
Pathogenesis
IDP02306
(
show subtarget assignments
)
1
cloned
Cj0079c
15791469
cdtA
cytolethal distending toxin [Campylobact...
268
Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...
Phase 3: June 2008
1SR4
24.3%
Campylobacter jejuni
Cellular processes
Pathogenesis
IDP90697
(
show subtarget assignments
)
8
cloned
Cj0098
15791486
fmt
methionyl-tRNA formyltransferase [Campyl...
305
Predicted Essential
Community Requests
3R8X
38%
Campylobacter jejuni
IDP90641
(
show subtarget assignments
)
8
purified
Cj0099
15791487
birA
biotin--protein ligase [Campylobacter je...
217
Predicted Essential
Community Requests
2EAY
27.2%
Campylobacter jejuni
IDP90738
(
show subtarget assignments
)
8
soluble
Cj0116
15791504
fabD
malonyl CoA-acyl carrier protein transac...
306
Predicted Essential
Community Requests
2H1Y
49.3%
Campylobacter jejuni
IDP90702
(
show subtarget assignments
)
8
expressed
Cj0134
15791522
thrB
homoserine kinase [Campylobacter jejuni ...
292
Predicted Essential
Community Requests
3HUL
30.2%
Campylobacter jejuni
IDP90832
(
show subtarget assignments
)
8
in_pdb
3R9U
Cj0146c
15791534
trxB
thioredoxin-disulfide reductase [Campylo...
312
Predicted Essential
Community Requests
3R9U
100%
Campylobacter jejuni
IDP02079
(
show subtarget assignments
)
1
expressed
Cj0173c
15791560
iron ABC transporter, ATP binding subuni...
302
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2D62
35.4%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02461
(
show subtarget assignments
)
1
cloned
Cj0176c
15791563
putative lipoprotein [Campylobacter jeju...
43
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
Campylobacter jejuni
Transport and binding proteins
Cations and iron carrying compounds
IDP02258
(
show subtarget assignments
)
1
cloned
Cj0178
15791565
putative outer membrane siderophore rece...
755
Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate
Phase 3: June 2008
3CSL
24.9%
Campylobacter jejuni
Cell envelope
Other
IDP90536
(
show subtarget assignments
)
8
purified
Cj0187c
15791574
purN
phosphoribosylglycinamide formyltransfer...
188
Predicted Essential
Community Requests
1C2T
38.6%
Campylobacter jejuni
IDP02097
(
show subtarget assignments
)
1
cloned
Cj0195
15791582
fliI
flagellum-specific ATP synthase [Campylo...
461
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
2DPY
40.3%
Campylobacter jejuni
Protein fate
Protein folding and stabilization
IDP90700
(
show subtarget assignments
)
8
soluble
Cj0196c
15791583
purF
amidophosphoribosyltransferase [Campylob...
445
Predicted Essential
Community Requests
1AO0
46.3%
Campylobacter jejuni
IDP90668
(
show subtarget assignments
)
8
purified
Cj0206
15791593
thrS
threonyl-tRNA synthetase [Campylobacter ...
602
Predicted Essential
Community Requests
1QF6
43%
Campylobacter jejuni
IDP90574
(
show subtarget assignments
)
8
in_pdb
3NX3
Cj0227
15791599
argD
acetylornithine aminotransferase [Campyl...
395
Predicted Essential
Community Requests
3NX3
100%
Campylobacter jejuni
IDP90707
(
show subtarget assignments
)
8
purified
Cj0233c
15791605
pyrE
orotate phosphoribosyltransferase [Campy...
202
Predicted Essential
Community Requests
2YZK
22.3%
Campylobacter jejuni
IDP01708
(
show subtarget assignments
)
1
expressed
Cj0241c
15791613
putative iron-binding protein [Campyloba...
133
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2AVK
26.3%
Campylobacter jejuni
Cellular processes
Other
IDP90750
(
show subtarget assignments
)
8
in_pdb
3PNU
Cj0259
15791630
pyrC
dihydroorotase [Campylobacter jejuni sub...
335
Predicted Essential
Community Requests
3PNU
99.7%
Campylobacter jejuni
IDP90704
(
show subtarget assignments
)
8
purified
Cj0269c
15791640
ilvE
branched-chain amino acid aminotransfera...
304
Predicted Essential
Community Requests
3U0G
55.6%
Campylobacter jejuni
IDP90748
(
show subtarget assignments
)
8
in_pdb
3R0S
Cj0274
15791645
lpxA
UDP-N-acetylglucosamine acyltransferase ...
263
Predicted Essential
Community Requests
3R0S
100%
Campylobacter jejuni
IDP90807
(
show subtarget assignments
)
8
cloned
Cj0279
15791649
carB
carbamoyl phosphate synthase large subun...
1089
Predicted Essential
Community Requests
1BXR
55.3%
Campylobacter jejuni
IDP90506
(
show subtarget assignments
)
8
in_pdb
3PLX
Cj0296c
15791664
panD
aspartate alpha-decarboxylase [Campyloba...
126
Predicted Essential
Community Requests
3PLX
80.2%
Campylobacter jejuni
IDP90800
(
show subtarget assignments
)
8
in_pdb
3MXT
3UY4
Cj0297c
15791665
panC
pantoate--beta-alanine ligase [Campyloba...
282
Predicted Essential
Community Requests
3MXT
100%
Campylobacter jejuni
IDP02180
(
show subtarget assignments
)
1
cloned
Cj0299
15791667
putative periplasmic beta-lactamase [Cam...
257
Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...
Phase 3: June 2008
1E3U
34.6%
Campylobacter jejuni
Transport and binding proteins
Anions
IDP90618
(
show subtarget assignments
)
8
purified
Cj0314
15791682
lysA
diaminopimelate decarboxylase [Campyloba...
402
Predicted Essential
Community Requests
2QGH
60.2%
Campylobacter jejuni
IDP90772
(
show subtarget assignments
)
8
soluble
Cj0316
15791684
pheA
chorismate mutase/prephenate dehydratase...
357
Predicted Essential
Community Requests
3MWB
27.5%
Campylobacter jejuni
IDP02359
(
show subtarget assignments
)
1
purified
Cj0319
15791687
fliG
flagellar motor switch protein G [Campyl...
342
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
3PKR
49.1%
Campylobacter jejuni
Cell envelope
Surface structures
IDP02242
(
show subtarget assignments
)
1
cloned
Cj0320
15791688
fliH
flagellar assembly protein H [Campylobac...
276
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02786
(
show subtarget assignments
)
1
purified
Cj0322
15791690
perR
FUR family transcriptional regulator [Ca...
136
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2FE3
32.4%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP90849
(
show subtarget assignments
)
8
in_pdb
3M5U
Cj0326
15791694
serC
phosphoserine aminotransferase [Campylob...
358
Predicted Essential
Community Requests
3M5U
100%
Campylobacter jejuni
IDP90814
(
show subtarget assignments
)
8
soluble
Cj0329c
15791697
plsX
putative glycerol-3-phosphate acyltransf...
328
Predicted Essential
Community Requests
1VI1
38.4%
Campylobacter jejuni
IDP90542
(
show subtarget assignments
)
8
in_pdb
3PJ9
Cj0332c
15791700
ndk
nucleoside diphosphate kinase [Campyloba...
137
Predicted Essential
Community Requests
3PJ9
100%
Campylobacter jejuni
IDP00330
(
show subtarget assignments
)
1
soluble
Cj0345
15791713
trpE
putative anthranilate synthase component...
416
Drug Target Function
Phase 2: March 2008
1QDL
32%
Campylobacter jejuni
Amino acid biosynthesis
Aromatic amino acid family
IDP00322
(
show subtarget assignments
)
1
expressed
Cj0346
15791714
trpD
anthranilate synthase component II
533
Drug Target Function
Phase 2: March 2008
1VQU
20.6%
Campylobacter jejuni
Amino acid biosynthesis
Aromatic amino acid family
IDP90509
(
show subtarget assignments
)
8
purified
Cj0347
15791715
trpF
N-(5'phosphoribosyl)anthranilate isomera...
199
Predicted Essential
Community Requests
1DL3
31.4%
Campylobacter jejuni
IDP90720
(
show subtarget assignments
)
8
purified
Cj0348
15791716
trpB
tryptophan synthase subunit beta [Campyl...
392
Predicted Essential
Community Requests
1V8Z
51.5%
Campylobacter jejuni
IDP90540
(
show subtarget assignments
)
8
in_pdb
3THA
Cj0349
15791717
trpA
tryptophan synthase subunit alpha [Campy...
249
Predicted Essential
Community Requests
3THA
100%
Campylobacter jejuni
IDP01715
(
show subtarget assignments
)
1
expressed
Cj0351
15791719
fliN
flagellar motor switch protein [Campylob...
102
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1O6A
29.4%
Campylobacter jejuni
Cell envelope
Other
IDP02364
(
show subtarget assignments
)
1
cloned
Cj0365c
15791732
putative outer membrane channel protein ...
492
Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...
Phase 3: June 2008
3PIK
24.8%
Campylobacter jejuni
Cellular processes
Toxin production and resistance
IDP02813
(
show subtarget assignments
)
1
cloned
Cj0367c
15791734
RND efflux system, membrane fusion prote...
367
Predicted virulence-Resistance to antibiotics and toxic compounds
Phase 3: June 2008
1T5E
29.2%
Campylobacter jejuni
Regulatory functions
Other
IDP90546
(
show subtarget assignments
)
8
in_pdb
3RU6
Cj0381c
15791748
pyrF
orotidine 5'-phosphate decarboxylase [Ca...
279
Predicted Essential
Community Requests
3RU6
100%
Campylobacter jejuni
IDP90519
(
show subtarget assignments
)
8
purified
Cj0383c
15791750
ribH
riboflavin synthase subunit beta [Campyl...
154
Predicted Essential
Community Requests
1HQK
51.9%
Campylobacter jejuni
IDP90656
(
show subtarget assignments
)
8
purified
Cj0384c
15791751
kdsA
2-dehydro-3-deoxyphosphooctonate aldolas...
271
Predicted Essential
Community Requests
1FWN
55.7%
Campylobacter jejuni
IDP90555
(
show subtarget assignments
)
8
in_pdb
3M5W
3TZL
Cj0388
15791755
trpS
tryptophanyl-tRNA synthetase [Campylobac...
319
Predicted Essential
Community Requests
3M5W
100%
Campylobacter jejuni
IDP90689
(
show subtarget assignments
)
8
soluble
Cj0389
15791756
serS
seryl-tRNA synthetase [Campylobacter jej...
411
Predicted Essential
Community Requests
2DQ3
48.4%
Campylobacter jejuni
IDP90685
(
show subtarget assignments
)
8
purified
Cj0401
15791768
lysS
lysyl-tRNA synthetase [Campylobacter jej...
501
Predicted Essential
Community Requests
1BBU
48.1%
Campylobacter jejuni
IDP90682
(
show subtarget assignments
)
8
in_pdb
3N0L
Cj0402
15791769
glyA
serine hydroxymethyltransferase [Campylo...
414
Predicted Essential
Community Requests
3N0L
100%
Campylobacter jejuni
IDP90864
(
show subtarget assignments
)
8
expressed
Cj0405
15791772
aroE
shikimate 5-dehydrogenase [Campylobacter...
262
Predicted Essential
Community Requests
3PHG
38.5%
Campylobacter jejuni
IDP90636
(
show subtarget assignments
)
8
purified
Cj0432c
15791799
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
402
Predicted Essential
Community Requests
1E0D
27.6%
Campylobacter jejuni
IDP90562
(
show subtarget assignments
)
8
purified
Cj0434
15791801
pgm
phosphoglyceromutase [Campylobacter jeju...
492
Predicted Essential
Community Requests
1EJJ
44%
Campylobacter jejuni
IDP90856
(
show subtarget assignments
)
8
crystallized
Cj0442
15791809
fabF
3-oxoacyl-(acyl carrier protein) synthas...
404
Predicted Essential
Community Requests
1J3N
52.7%
Campylobacter jejuni
IDP90710
(
show subtarget assignments
)
8
purified
Cj0451
15791815
rep
ribulose-phosphate 3-epimerase [Campylob...
215
Predicted Essential
Community Requests
1RPX
48.4%
Campylobacter jejuni
IDP90599
(
show subtarget assignments
)
8
purified
Cj0460
15791824
nusA
transcription elongation factor NusA [Ca...
362
Predicted Essential
Community Requests
1HH2
33.4%
Campylobacter jejuni
IDP90699
(
show subtarget assignments
)
8
cloned
Cj0478
15791842
rpoB
DNA-directed RNA polymerase subunit beta...
1378
Predicted Essential
Community Requests
3IYD
47.9%
Campylobacter jejuni
IDP90573
(
show subtarget assignments
)
8
cloned
Cj0479
15791843
rpoC
DNA-directed RNA polymerase beta' chain ...
1517
Predicted Essential
Community Requests
3IYD
46.1%
Campylobacter jejuni
IDP90754
(
show subtarget assignments
)
8
purified
Cj0498
15791862
trpC
indole-3-glycerol phosphate synthase [Ca...
258
Predicted Essential
Community Requests
3TSM
39%
Campylobacter jejuni
IDP90719
(
show subtarget assignments
)
8
soluble
Cj0503c
15791865
hemH
ferrochelatase [Campylobacter jejuni sub...
303
Predicted Essential
Community Requests
2PO7
31%
Campylobacter jejuni
IDP90679
(
show subtarget assignments
)
8
cloned
Cj0506
15791868
alaS
alanyl-tRNA synthetase [Campylobacter je...
842
Predicted Essential
Community Requests
3HXU
28.5%
Campylobacter jejuni
IDP90788
(
show subtarget assignments
)
8
purified
Cj0512
15791874
purC
phosphoribosylaminoimidazole-succinocarb...
236
Predicted Essential
Community Requests
3NUA
50.8%
Campylobacter jejuni
IDP90514
(
show subtarget assignments
)
8
crystallized
Cj0513
15791875
phosphoribosylformylglycinamidine syntha...
81
Predicted Essential
Community Requests
1T4A
46.9%
Campylobacter jejuni
IDP90827
(
show subtarget assignments
)
8
expressed
Cj0514
15791876
purQ
phosphoribosylformylglycinamidine syntha...
223
Predicted Essential
Community Requests
3D54
40.4%
Campylobacter jejuni
IDP01827
(
show subtarget assignments
)
1
expressed
Cj0526c
15791887
fliE
flagellar hook-basal body protein FliE [...
98
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Cell envelope
Other
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