Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01108 (show subtarget assignments)	1	in_pdb	BA_3860	30258377		copper-ion-binding protein	68	Conserved Gene / Pathway	Phase 2: March 2008	2L3M	100%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01109 (show subtarget assignments)	1	soluble	GBAA_pXO1_0148	47566460		hypothetical protein GBAA_pXO1_0148	150	Virulence Associated Factor	Phase 2: March 2008	3PMD	100%	Bacillus anthracis

IDP01110 (show subtarget assignments)	1	in_pdb 3RYK	BA_1229	30255178	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase	181	Conserved Gene / Pathway	Phase 2: March 2008	3RYK	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01111 (show subtarget assignments)	1	cloned	BA_1135	49035527		Major cold shock protein cspA	67	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	73.1%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01112 (show subtarget assignments)	1	in_pdb 3G48	BA_2064	30256713	csaA	chaperone CsaA	109	Conserved Gene / Pathway	Phase 2: March 2008	3G48	99.1%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01113 (show subtarget assignments)	1	expressed	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01114 (show subtarget assignments)	1	soluble	BA_4901	38502945		Septation ring formation regulator ezrA	570	Conserved Gene / Pathway	Phase 2: March 2008			Bacillus anthracis	Cellular processes	Cell division

IDP01115 (show subtarget assignments)	1	in_pdb 3IG4	BA_1901	30256561		xaa-pro aminopeptidase, putative	427	Drug Target Function	Phase 2: March 2008	3IG4	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01116 (show subtarget assignments)	1	expressed	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01117 (show subtarget assignments)	1	purified	BA_3754	33301235		LexA repressor	206	Conserved Gene / Pathway	Phase 2: March 2008	3K2Z	38.3%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP01118 (show subtarget assignments)	1	crystallized	BA_4030	81837831		Bifunctional protein pyrR [Includes: Pyr...	180	Conserved Gene / Pathway	Phase 2: March 2008	1A3C	73.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01119 (show subtarget assignments)	1	purified	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP01120 (show subtarget assignments)	1	purified	BA_1194	30254907		oligopeptide ABC transporter, ATP-bindin...	347	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01121 (show subtarget assignments)	1	expressed	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01122 (show subtarget assignments)	1	soluble	BA_4045	30258552	ftsZ	cell division protein FtsZ	386	Conserved Gene / Pathway	Phase 2: March 2008	2VAM	78.1%	Bacillus anthracis	Cellular processes	Cell division

IDP01123 (show subtarget assignments)	1	purified	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01124 (show subtarget assignments)	1	soluble	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01125 (show subtarget assignments)	1	expressed	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01126 (show subtarget assignments)	1	cloned	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01127 (show subtarget assignments)	1	expressed	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01128 (show subtarget assignments)	1	expressed	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01129 (show subtarget assignments)	1	purified	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01130 (show subtarget assignments)	1	soluble	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01131 (show subtarget assignments)	1	in_pdb 3IHS	BA_5381	30259854	ptsH-2	phosphocarrier protein HPr	82	Conserved Gene / Pathway	Phase 2: March 2008	3IHS	100%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01132 (show subtarget assignments)	1	soluble	BA_4703	30259197	loN2	ATP-dependent protease LA	557	Drug Target Function	Phase 2: March 2008	3K1J	26.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01133 (show subtarget assignments)	1	in_pdb 3SKS	BA_1353	30255290		oligoendopeptidase F, putative	564	Drug Target Function	Phase 2: March 2008	3SKS	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01134 (show subtarget assignments)	1	purified	BA_2001	30256654		intracellular serine protease	316	Drug Target Function	Phase 2: March 2008	2WV7	52.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01135 (show subtarget assignments)	1	expressed	BA_3911	30258425		renal dipeptidase family protein	307	Drug Target Function	Phase 2: March 2008	3LU2	45.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01136 (show subtarget assignments)	1	soluble	BA_3942	30258453		zinc protease, insulinase family	413	Drug Target Function	Phase 2: March 2008	3HDI	63%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01137 (show subtarget assignments)	1	in_pdb 3TY6	BA_3968	47605672		ATP-dependent protease hslV	180	Drug Target Function	Phase 2: March 2008	3TY6	100%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01138 (show subtarget assignments)	1	purified	BA_4230	30258733		alpha-amylase	586	Drug Target Function	Phase 2: March 2008	1J0H	61%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01139 (show subtarget assignments)	1	in_pdb 3Q6D	BA_4422	30258918	pepQ-1	proline dipeptidase	353	Drug Target Function	Phase 2: March 2008	3Q6D	100%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01140 (show subtarget assignments)	1	purified	BA_4546	33301122		Germination protease precursor (Spore pr...	368	Drug Target Function	Phase 2: March 2008	1C8B	70.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01141 (show subtarget assignments)	1	crystallized	BA_5155	56404588		Probable cytosol aminopeptidase (Leucine...	494	Drug Target Function	Phase 2: March 2008	3H8E	38.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01142 (show subtarget assignments)	1	expressed	BA_1249	30255198	pabA-2	para-aminobenzoate synthase glutamine am...	195	Drug Target Function	Phase 2: March 2008	1QDL	43.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01143 (show subtarget assignments)	1	in_pdb 3R8Y	BA_4194	30258698		2,3,4,5-tetrahydropyridine-2-carboxylate...	240	Drug Target Function	Phase 2: March 2008	3R8Y	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01144 (show subtarget assignments)	1	purified	BA_5153	30259639		phosphoglucomutase/phosphomannomutase fa...	574	Drug Target Function	Phase 2: March 2008	2FUV	26.3%	Bacillus anthracis	Energy metabolism	Sugars

IDP01145 (show subtarget assignments)	1	expressed	BA_0188	30253695		oligopeptide ABC transporter, ATP-bindin...	257	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	34.6%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01146 (show subtarget assignments)	1	cloned	BA_0235	30253735		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	26.8%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01147 (show subtarget assignments)	1	expressed	BA_0639	30254242		amino acid ABC transporter, ATP-binding ...	243	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	60.5%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01148 (show subtarget assignments)	1	purified	BA_1159	30254878	katB	catalase	488	Conserved Gene / Pathway	Phase 2: March 2008	2J2M	64.8%	Bacillus anthracis	Cellular processes	Detoxification

IDP01149 (show subtarget assignments)	1	soluble	BA_1195	30254908		oligopeptide ABC transporter, ATP-bindin...	311	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	30.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01150 (show subtarget assignments)	1	expressed	BA_4493	34582388		Phosphate import ATP-binding protein pst...	271	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.8%	Bacillus anthracis	Transport and binding proteins	Anions

IDP01151 (show subtarget assignments)	0	work_stopped	BA_5433	30259901		UDP-N-acetylglucosamine 2-epimerase	371	Conserved Gene / Pathway	Phase 2: March 2008	3BEO	99.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01152 (show subtarget assignments)	1	purified	BA_5520	30259980	mbl	mbl protein	333	Conserved Gene / Pathway	Phase 2: March 2008	1JCE	50.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01153 (show subtarget assignments)	1	cloned	BA_5712	30260159		yycI protein	280	Conserved Gene / Pathway	Phase 2: March 2008	2O3O	28.2%	Bacillus anthracis	Cellular processes	Cell division

IDP01154 (show subtarget assignments)	1	expressed	BA_0139	56748760		Cobalt import ATP-binding protein cbiO 1...	280	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01155 (show subtarget assignments)	1	cloned	BA_0312	81837905		Methionine import ATP-binding protein me...	339	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	49.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01156 (show subtarget assignments)	1	expressed	BA_0798	30254389		ABC transporter, ATP-binding protein	224	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	50.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01157 (show subtarget assignments)	1	expressed	BA_3749	60390552		Phosphonates import ATP-binding protein ...	257	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	36.6%	Bacillus anthracis	Transport and binding proteins	Other

IDP01158 (show subtarget assignments)	1	expressed	BA_4669	30259165		ABC transporter, ATP-binding protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01159 (show subtarget assignments)	1	soluble	BA_4745	30259235		ABC transporter, ATP-binding protein	294	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	24.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01160 (show subtarget assignments)	1	expressed	BA_4774	30259261		bacitracin ABC transporter, ATP-binding ...	307	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	25.7%	Bacillus anthracis	Transport and binding proteins	Other

IDP01161 (show subtarget assignments)	1	purified	BA_4997	30259489		ABC transporter, ATP-binding protein	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	38.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01162 (show subtarget assignments)	1	expressed	BA_5496	30259957		ABC transporter, ATP-binding protein	226	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	54.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01163 (show subtarget assignments)	1	purified	BA_5526	30259986		ABC transporter, ATP-binding protein	280	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01164 (show subtarget assignments)	1	soluble	BA_5600	30260056		ABC transporter, ATP-binding protein	300	Conserved Gene / Pathway	Phase 2: March 2008	2YYZ	31.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01165 (show subtarget assignments)	1	expressed	BA_5650	30260099		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01166 (show subtarget assignments)	1	cloned	GBAA_pXO1_0190	47566502		hypothetical protein GBAA_pXO1_0190	410	Virulence Associated Factor	Phase 2: March 2008			Bacillus anthracis

IDP01167 (show subtarget assignments)	1	expressed	GBAA_pXO2_0060	47566729		capsule synthesis trans-acting positive ...	482	Virulence Associated Factor	Phase 2: March 2008	3SQN	22%	Bacillus anthracis

IDP01168 (show subtarget assignments)	1	expressed	GBAA_pXO2_0084	47566748		capsule synthesis trans-acting positive ...	483	Virulence Associated Factor	Phase 2: March 2008	3SQN	8.5%	Bacillus anthracis

IDP01169 (show subtarget assignments)	1	cloned	GBAA_pXO1_0146	47566458	atxA	transcriptional activator atxa, (pxo1-11...	475	Virulence Associated Factor	Phase 2: March 2008	3SQN	20.4%	Bacillus anthracis

IDP01170 (show subtarget assignments)	1	cloned	BA_0165	30253674		prolyl oligopeptidase family protein, pu...	654	Drug Target Function	Phase 2: March 2008	1Z68	11.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01171 (show subtarget assignments)	1	expressed	BA_1140	30254861	sipT	signal peptidase I	187	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01172 (show subtarget assignments)	1	purified	BA_1206	30255158	pepF-1	oligoendopeptidase F	608	Drug Target Function	Phase 2: March 2008	2QR4	51%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01173 (show subtarget assignments)	1	cloned	BA_1587	30255887		thermostable carboxypeptidase 1	505	Drug Target Function	Phase 2: March 2008	3HQ2	60.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01174 (show subtarget assignments)	1	expressed	BA_2823	30257425		hypothetical protein BA_2823	375	Drug Target Function	Phase 2: March 2008			Bacillus anthracis

IDP01175 (show subtarget assignments)	1	expressed	BA_2825	30257427		peptidase M3 family protein	548	Drug Target Function	Phase 2: March 2008	3CE2	22.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01176 (show subtarget assignments)	1	expressed	BA_2869	30257466		peptidase, putative	358	Drug Target Function	Phase 2: March 2008	3CE2	22.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01177 (show subtarget assignments)	1	cloned	BA_4515	30259020	sigA	RNA polymerase sigma-43 factor	373	Conserved Gene / Pathway	Phase 2: March 2008	1L9U	51.2%	Bacillus anthracis	Transcription	Transcription factors

IDP01178 (show subtarget assignments)	1	in_pdb 3TSB 3TSD	BA_0008	30253523	guaB	inosine-5'-monophosphate dehydrogenase	487	Conserved Gene / Pathway	Phase 2: March 2008	3TSB	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01179 (show subtarget assignments)	1	purified	BA_0048	81583548		Bifunctional protein glmU [Includes: UDP...	459	Drug Target Function	Phase 2: March 2008	1G95	51.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01180 (show subtarget assignments)	1	cloned	BA_0049	46396353		Ribose-phosphate pyrophosphokinase (RPPK...	317	Conserved Gene / Pathway	Phase 2: March 2008	1DKR	85.5%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01181 (show subtarget assignments)	1	purified	BA_0085	38372318		2-C-methyl-D-erythritol 2,4-cyclodiphosp...	158	Drug Target Function	Phase 2: March 2008	3F6M	64.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01182 (show subtarget assignments)	1	in_pdb 3HYK	BA_0250	61211622		Holo-[acyl-carrier-protein] synthase (Ho...	119	Drug Target Function	Phase 2: March 2008	3HYK	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01183 (show subtarget assignments)	1	soluble	BA_0266	60389755		10 kDa chaperonin (Protein Cpn10) (groES...	94	Conserved Gene / Pathway	Phase 2: March 2008	1WNR	66%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01184 (show subtarget assignments)	1	purified	BA_0267	41016866		60 kDa chaperonin (Protein Cpn60) (groEL...	544	Conserved Gene / Pathway	Phase 2: March 2008	1WE3	67.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01185 (show subtarget assignments)	1	cloned	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01186 (show subtarget assignments)	1	purified	BA_0298	81584380		Bifunctional purine biosynthesis protein...	511	Conserved Gene / Pathway	Phase 2: March 2008	3ZZM	44.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01187 (show subtarget assignments)	1	purified	BA_0485	30254015		prophage LambdaBa04, glycosyl hydrolase,...	265	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	71.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01188 (show subtarget assignments)	1	expressed	BA_0502	30254030		penicillin-binding protein, putative	412	Drug Target Function	Phase 2: March 2008	2QMI	21.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01189 (show subtarget assignments)	1	expressed	BA_0505	30254033		glycosyl transferase, group 2 family pro...	528	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01190 (show subtarget assignments)	1	cloned	BA_0872	30254622		N-acetylmuramoyl-L-alanine amidase, fami...	348	Drug Target Function	Phase 2: March 2008	3HMB	25.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01191 (show subtarget assignments)	1	purified	BA_0882	81837776		Protein translocase subunit secA 2	788	Conserved Gene / Pathway	Phase 2: March 2008	1M6N	48%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01192 (show subtarget assignments)	1	purified	BA_1184	34098435		3-oxoacyl-[acyl-carrier-protein] synthas...	310	Drug Target Function	Phase 2: March 2008	1ZOW	61%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01193 (show subtarget assignments)	1	purified	BA_1185	30254899	fabF	3-oxoacyl-(acyl-carrier-protein) synthas...	412	Drug Target Function	Phase 2: March 2008	3O04	67.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01194 (show subtarget assignments)	1	purified	BA_1230	30255179	rfbB	dTDP-glucose 4,6-dehydratase	322	Conserved Gene / Pathway	Phase 2: March 2008	2HUN	51.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01195 (show subtarget assignments)	1	in_pdb 3SC6	BA_1231	30255180	rfbD	dTDP-4-dehydrorhamnose reductase	284	Drug Target Function	Phase 2: March 2008	3SC6	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01196 (show subtarget assignments)	1	expressed	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01197 (show subtarget assignments)	0	work_stopped	BA_1389	81715334		D-alanine--poly(phosphoribitol) ligase s...	503	Conserved Gene / Pathway	Phase 2: March 2008	3DHV	99.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01198 (show subtarget assignments)	1	purified	BA_1518	59798071		Cytidylate kinase (CK) (Cytidine monopho...	225	Conserved Gene / Pathway	Phase 2: March 2008	1Q3T	53.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01199 (show subtarget assignments)	1	purified	BA_1537	67460530		Chorismate synthase 1 (5-enolpyruvylshik...	390	Drug Target Function	Phase 2: March 2008	1QXO	59%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01200 (show subtarget assignments)	1	cloned	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01201 (show subtarget assignments)	1	purified	BA_1826	34098434		3-oxoacyl-[acyl-carrier-protein] synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	40.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01202 (show subtarget assignments)	1	purified	BA_2079	30256728	dal-2	alanine racemase	391	Drug Target Function	Phase 2: March 2008	3E5P	41.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01203 (show subtarget assignments)	1	purified	BA_2083	30256732		glycosyltransferase, MGT family	402	Conserved Gene / Pathway	Phase 2: March 2008	3IAA	29.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01204 (show subtarget assignments)	1	crystallized	BA_2274	30256914		glycosyl transferase, group 2 family pro...	406	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01205 (show subtarget assignments)	1	in_pdb 3OS6	BA_2369	30257005	dhbC	isochorismate synthase DhbC	399	Drug Target Function	Phase 2: March 2008	3OS6	99.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01206 (show subtarget assignments)	1	purified	BA_2446	30257076		N-acetylmuramoyl-L-alanine amidase, fami...	245	Conserved Gene / Pathway	Phase 2: March 2008	1XOV	26.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01207 (show subtarget assignments)	1	in_pdb 3R5X 3R23	BA_2610	39930865		D-alanine--D-alanine ligase (D-alanylala...	304	Conserved Gene / Pathway	Phase 2: March 2008	3R23	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01108
(show subtarget assignments)

1

in_pdb

BA_3860

30258377

copper-ion-binding protein

68

Conserved Gene / Pathway

Phase 2: March 2008

2L3M

100%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01109
(show subtarget assignments)

1

soluble

GBAA_pXO1_0148

47566460

hypothetical protein GBAA_pXO1_0148

150

Virulence Associated Factor

Phase 2: March 2008

3PMD

100%

Bacillus anthracis

IDP01110
(show subtarget assignments)

1

in_pdb
3RYK

BA_1229

30255178

rfbC

dTDP-4-dehydrorhamnose 3,5-epimerase

181

Conserved Gene / Pathway

Phase 2: March 2008

3RYK

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01111
(show subtarget assignments)

1

cloned

BA_1135

49035527

Major cold shock protein cspA

67

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

73.1%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01112
(show subtarget assignments)

1

in_pdb
3G48

BA_2064

30256713

csaA

chaperone CsaA

109

Conserved Gene / Pathway

Phase 2: March 2008

3G48

99.1%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01113
(show subtarget assignments)

1

expressed

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01114
(show subtarget assignments)

1

soluble

BA_4901

38502945

Septation ring formation regulator ezrA

570

Conserved Gene / Pathway

Phase 2: March 2008

Bacillus anthracis

Cellular processes

Cell division

IDP01115
(show subtarget assignments)

1

in_pdb
3IG4

BA_1901

30256561

xaa-pro aminopeptidase, putative

427

Drug Target Function

Phase 2: March 2008

3IG4

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01116
(show subtarget assignments)

1

expressed

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01117
(show subtarget assignments)

1

purified

BA_3754

33301235

LexA repressor

206

Conserved Gene / Pathway

Phase 2: March 2008

3K2Z

38.3%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP01118
(show subtarget assignments)

1

crystallized

BA_4030

81837831

Bifunctional protein pyrR [Includes: Pyr...

180

Conserved Gene / Pathway

Phase 2: March 2008

1A3C

73.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01119
(show subtarget assignments)

1

purified

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP01120
(show subtarget assignments)

1

purified

BA_1194

30254907

oligopeptide ABC transporter, ATP-bindin...

347

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01121
(show subtarget assignments)

1

expressed

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01122
(show subtarget assignments)

1

soluble

BA_4045

30258552

ftsZ

cell division protein FtsZ

386

Conserved Gene / Pathway

Phase 2: March 2008

2VAM

78.1%

Bacillus anthracis

Cellular processes

Cell division

IDP01123
(show subtarget assignments)

1

purified

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01124
(show subtarget assignments)

1

soluble

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01125
(show subtarget assignments)

1

expressed

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01126
(show subtarget assignments)

1

cloned

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01127
(show subtarget assignments)

1

expressed

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01128
(show subtarget assignments)

1

expressed

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01129
(show subtarget assignments)

1

purified

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01130
(show subtarget assignments)

1

soluble

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01131
(show subtarget assignments)

1

in_pdb
3IHS

BA_5381

30259854

ptsH-2

phosphocarrier protein HPr

82

Conserved Gene / Pathway

Phase 2: March 2008

3IHS

100%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01132
(show subtarget assignments)

1

soluble

BA_4703

30259197

loN2

ATP-dependent protease LA

557

Drug Target Function

Phase 2: March 2008

3K1J

26.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01133
(show subtarget assignments)

1

in_pdb
3SKS

BA_1353

30255290

oligoendopeptidase F, putative

564

Drug Target Function

Phase 2: March 2008

3SKS

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01134
(show subtarget assignments)

1

purified

BA_2001

30256654

intracellular serine protease

316

Drug Target Function

Phase 2: March 2008

2WV7

52.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01135
(show subtarget assignments)

1

expressed

BA_3911

30258425

renal dipeptidase family protein

307

Drug Target Function

Phase 2: March 2008

3LU2

45.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01136
(show subtarget assignments)

1

soluble

BA_3942

30258453

zinc protease, insulinase family

413

Drug Target Function

Phase 2: March 2008

3HDI

63%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01137
(show subtarget assignments)

1

in_pdb
3TY6

BA_3968

47605672

ATP-dependent protease hslV

180

Drug Target Function

Phase 2: March 2008

3TY6

100%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01138
(show subtarget assignments)

1

purified

BA_4230

30258733

alpha-amylase

586

Drug Target Function

Phase 2: March 2008

1J0H

61%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01139
(show subtarget assignments)

1

in_pdb
3Q6D

BA_4422

30258918

pepQ-1

proline dipeptidase

353

Drug Target Function

Phase 2: March 2008

3Q6D

100%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01140
(show subtarget assignments)

1

purified

BA_4546

33301122

Germination protease precursor (Spore pr...

368

Drug Target Function

Phase 2: March 2008

1C8B

70.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01141
(show subtarget assignments)

1

crystallized

BA_5155

56404588

Probable cytosol aminopeptidase (Leucine...

494

Drug Target Function

Phase 2: March 2008

3H8E

38.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01142
(show subtarget assignments)

1

expressed

BA_1249

30255198

pabA-2

para-aminobenzoate synthase glutamine am...

195

Drug Target Function

Phase 2: March 2008

1QDL

43.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01143
(show subtarget assignments)

1

in_pdb
3R8Y

BA_4194

30258698

2,3,4,5-tetrahydropyridine-2-carboxylate...

240

Drug Target Function

Phase 2: March 2008

3R8Y

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01144
(show subtarget assignments)

1

purified

BA_5153

30259639

phosphoglucomutase/phosphomannomutase fa...

574

Drug Target Function

Phase 2: March 2008

2FUV

26.3%

Bacillus anthracis

Energy metabolism

Sugars

IDP01145
(show subtarget assignments)

1

expressed

BA_0188

30253695

oligopeptide ABC transporter, ATP-bindin...

257

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

34.6%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01146
(show subtarget assignments)

1

cloned

BA_0235

30253735

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

26.8%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01147
(show subtarget assignments)

1

expressed

BA_0639

30254242

amino acid ABC transporter, ATP-binding ...

243

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

60.5%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01148
(show subtarget assignments)

1

purified

BA_1159

30254878

katB

catalase

488

Conserved Gene / Pathway

Phase 2: March 2008

2J2M

64.8%

Bacillus anthracis

Cellular processes

Detoxification

IDP01149
(show subtarget assignments)

1

soluble

BA_1195

30254908

oligopeptide ABC transporter, ATP-bindin...

311

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

30.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01150
(show subtarget assignments)

1

expressed

BA_4493

34582388

Phosphate import ATP-binding protein pst...

271

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.8%

Bacillus anthracis

Transport and binding proteins

Anions

IDP01151
(show subtarget assignments)

0

work_stopped

BA_5433

30259901

UDP-N-acetylglucosamine 2-epimerase

371

Conserved Gene / Pathway

Phase 2: March 2008

3BEO

99.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01152
(show subtarget assignments)

1

purified

BA_5520

30259980

mbl

mbl protein

333

Conserved Gene / Pathway

Phase 2: March 2008

1JCE

50.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01153
(show subtarget assignments)

1

cloned

BA_5712

30260159

yycI protein

280

Conserved Gene / Pathway

Phase 2: March 2008

2O3O

28.2%

Bacillus anthracis

Cellular processes

Cell division

IDP01154
(show subtarget assignments)

1

expressed

BA_0139

56748760

Cobalt import ATP-binding protein cbiO 1...

280

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01155
(show subtarget assignments)

1

cloned

BA_0312

81837905

Methionine import ATP-binding protein me...

339

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

49.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01156
(show subtarget assignments)

1

expressed

BA_0798

30254389

ABC transporter, ATP-binding protein

224

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

50.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01157
(show subtarget assignments)

1

expressed

BA_3749

60390552

Phosphonates import ATP-binding protein ...

257

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

36.6%

Bacillus anthracis

Transport and binding proteins

Other

IDP01158
(show subtarget assignments)

1

expressed

BA_4669

30259165

ABC transporter, ATP-binding protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01159
(show subtarget assignments)

1

soluble

BA_4745

30259235

ABC transporter, ATP-binding protein

294

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

24.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01160
(show subtarget assignments)

1

expressed

BA_4774

30259261

bacitracin ABC transporter, ATP-binding ...

307

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

25.7%

Bacillus anthracis

Transport and binding proteins

Other

IDP01161
(show subtarget assignments)

1

purified

BA_4997

30259489

ABC transporter, ATP-binding protein

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

38.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01162
(show subtarget assignments)

1

expressed

BA_5496

30259957

ABC transporter, ATP-binding protein

226

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

54.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01163
(show subtarget assignments)

1

purified

BA_5526

30259986

ABC transporter, ATP-binding protein

280

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01164
(show subtarget assignments)

1

soluble

BA_5600

30260056

ABC transporter, ATP-binding protein

300

Conserved Gene / Pathway

Phase 2: March 2008

2YYZ

31.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01165
(show subtarget assignments)

1

expressed

BA_5650

30260099

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01166
(show subtarget assignments)

1

cloned

GBAA_pXO1_0190

47566502

hypothetical protein GBAA_pXO1_0190

410

Virulence Associated Factor

Phase 2: March 2008

Bacillus anthracis

IDP01167
(show subtarget assignments)

1

expressed

GBAA_pXO2_0060

47566729

capsule synthesis trans-acting positive ...

482

Virulence Associated Factor

Phase 2: March 2008

3SQN

22%

Bacillus anthracis

IDP01168
(show subtarget assignments)

1

expressed

GBAA_pXO2_0084

47566748

capsule synthesis trans-acting positive ...

483

Virulence Associated Factor

Phase 2: March 2008

3SQN

8.5%

Bacillus anthracis

IDP01169
(show subtarget assignments)

1

cloned

GBAA_pXO1_0146

47566458

atxA

transcriptional activator atxa, (pxo1-11...

475

Virulence Associated Factor

Phase 2: March 2008

3SQN

20.4%

Bacillus anthracis

IDP01170
(show subtarget assignments)

1

cloned

BA_0165

30253674

prolyl oligopeptidase family protein, pu...

654

Drug Target Function

Phase 2: March 2008

1Z68

11.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01171
(show subtarget assignments)

1

expressed

BA_1140

30254861

sipT

signal peptidase I

187

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01172
(show subtarget assignments)

1

purified

BA_1206

30255158

pepF-1

oligoendopeptidase F

608

Drug Target Function

Phase 2: March 2008

2QR4

51%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01173
(show subtarget assignments)

1

cloned

BA_1587

30255887

thermostable carboxypeptidase 1

505

Drug Target Function

Phase 2: March 2008

3HQ2

60.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01174
(show subtarget assignments)

1

expressed

BA_2823

30257425

hypothetical protein BA_2823

375

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

IDP01175
(show subtarget assignments)

1

expressed

BA_2825

30257427

peptidase M3 family protein

548

Drug Target Function

Phase 2: March 2008

3CE2

22.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01176
(show subtarget assignments)

1

expressed

BA_2869

30257466

peptidase, putative

358

Drug Target Function

Phase 2: March 2008

3CE2

22.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01177
(show subtarget assignments)

1

cloned

BA_4515

30259020

sigA

RNA polymerase sigma-43 factor

373

Conserved Gene / Pathway

Phase 2: March 2008

1L9U

51.2%

Bacillus anthracis

Transcription

Transcription factors

IDP01178
(show subtarget assignments)

1

in_pdb
3TSB
3TSD

BA_0008

30253523

guaB

inosine-5'-monophosphate dehydrogenase

487

Conserved Gene / Pathway

Phase 2: March 2008

3TSB

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01179
(show subtarget assignments)

1

purified

BA_0048

81583548

Bifunctional protein glmU [Includes: UDP...

459

Drug Target Function

Phase 2: March 2008

1G95

51.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01180
(show subtarget assignments)

1

cloned

BA_0049

46396353

Ribose-phosphate pyrophosphokinase (RPPK...

317

Conserved Gene / Pathway

Phase 2: March 2008

1DKR

85.5%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01181
(show subtarget assignments)

1

purified

BA_0085

38372318

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

158

Drug Target Function

Phase 2: March 2008

3F6M

64.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01182
(show subtarget assignments)

1

in_pdb
3HYK

BA_0250

61211622

Holo-[acyl-carrier-protein] synthase (Ho...

119

Drug Target Function

Phase 2: March 2008

3HYK

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01183
(show subtarget assignments)

1

soluble

BA_0266

60389755

10 kDa chaperonin (Protein Cpn10) (groES...

94

Conserved Gene / Pathway

Phase 2: March 2008

1WNR

66%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01184
(show subtarget assignments)

1

purified

BA_0267

41016866

60 kDa chaperonin (Protein Cpn60) (groEL...

544

Conserved Gene / Pathway

Phase 2: March 2008

1WE3

67.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01185
(show subtarget assignments)

1

cloned

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01186
(show subtarget assignments)

1

purified

BA_0298

81584380

Bifunctional purine biosynthesis protein...

511

Conserved Gene / Pathway

Phase 2: March 2008

3ZZM

44.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01187
(show subtarget assignments)

1

purified

BA_0485

30254015

prophage LambdaBa04, glycosyl hydrolase,...

265

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

71.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01188
(show subtarget assignments)

1

expressed

BA_0502

30254030

penicillin-binding protein, putative

412

Drug Target Function

Phase 2: March 2008

2QMI

21.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01189
(show subtarget assignments)

1

expressed

BA_0505

30254033

glycosyl transferase, group 2 family pro...

528

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01190
(show subtarget assignments)

1

cloned

BA_0872

30254622

N-acetylmuramoyl-L-alanine amidase, fami...

348

Drug Target Function

Phase 2: March 2008

3HMB

25.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01191
(show subtarget assignments)

1

purified

BA_0882

81837776

Protein translocase subunit secA 2

788

Conserved Gene / Pathway

Phase 2: March 2008

1M6N

48%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01192
(show subtarget assignments)

1

purified

BA_1184

34098435

3-oxoacyl-[acyl-carrier-protein] synthas...

310

Drug Target Function

Phase 2: March 2008

1ZOW

61%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01193
(show subtarget assignments)

1

purified

BA_1185

30254899

fabF

3-oxoacyl-(acyl-carrier-protein) synthas...

412

Drug Target Function

Phase 2: March 2008

3O04

67.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01194
(show subtarget assignments)

1

purified

BA_1230

30255179

rfbB

dTDP-glucose 4,6-dehydratase

322

Conserved Gene / Pathway

Phase 2: March 2008

2HUN

51.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01195
(show subtarget assignments)

1

in_pdb
3SC6

BA_1231

30255180

rfbD

dTDP-4-dehydrorhamnose reductase

284

Drug Target Function

Phase 2: March 2008

3SC6

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01196
(show subtarget assignments)

1

expressed

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01197
(show subtarget assignments)

0

work_stopped

BA_1389

81715334

D-alanine--poly(phosphoribitol) ligase s...

503

Conserved Gene / Pathway

Phase 2: March 2008

3DHV

99.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01198
(show subtarget assignments)

1

purified

BA_1518

59798071

Cytidylate kinase (CK) (Cytidine monopho...

225

Conserved Gene / Pathway

Phase 2: March 2008

1Q3T

53.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01199
(show subtarget assignments)

1

purified

BA_1537

67460530

Chorismate synthase 1 (5-enolpyruvylshik...

390

Drug Target Function

Phase 2: March 2008

1QXO

59%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01200
(show subtarget assignments)

1

cloned

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01201
(show subtarget assignments)

1

purified

BA_1826

34098434

3-oxoacyl-[acyl-carrier-protein] synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

40.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01202
(show subtarget assignments)

1

purified

BA_2079

30256728

dal-2

alanine racemase

391

Drug Target Function

Phase 2: March 2008

3E5P

41.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01203
(show subtarget assignments)

1

purified

BA_2083

30256732

glycosyltransferase, MGT family

402

Conserved Gene / Pathway

Phase 2: March 2008

3IAA

29.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01204
(show subtarget assignments)

1

crystallized

BA_2274

30256914

glycosyl transferase, group 2 family pro...

406

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01205
(show subtarget assignments)

1

in_pdb
3OS6

BA_2369

30257005

dhbC

isochorismate synthase DhbC

399

Drug Target Function

Phase 2: March 2008

3OS6

99.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01206
(show subtarget assignments)

1

purified

BA_2446

30257076

N-acetylmuramoyl-L-alanine amidase, fami...

245

Conserved Gene / Pathway

Phase 2: March 2008

1XOV

26.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01207
(show subtarget assignments)

1

in_pdb
3R5X
3R23

BA_2610

39930865

D-alanine--D-alanine ligase (D-alanylala...

304

Conserved Gene / Pathway

Phase 2: March 2008

3R23

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

Targets