Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01044 (show subtarget assignments)	1	soluble	STM3070	16766371	epd	D-erythrose 4-phosphate dehydrogenase	348	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	91.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01043 (show subtarget assignments)	1	soluble	STM2985	16766289	ygdK	putative FeS center assembly protein	147	Conserved Gene / Pathway	Phase 2: March 2008	1NI7	86.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01038 (show subtarget assignments)	1	in_pdb 3GHZ	STM2929	16766235	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	159	Drug Target Function	Phase 2: March 2008	3GHZ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01034 (show subtarget assignments)	0	work_stopped	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02662 (show subtarget assignments)	1	purified	lmo1676	16803716	menF	menaquinone-specific isochorismate synth...	462	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3HWO	23.6%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00230 (show subtarget assignments)	1	purified	YPO3444	16123592	-	putative acetyltransferase	167	Virulence	Phase 1: October 2007	2GE3	18%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01012 (show subtarget assignments)	1	purified	STM2578	16765898	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Conserved Gene / Pathway	Phase 2: March 2008	1M5W	93.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00534 (show subtarget assignments)	1	purified	YPO3367	16123517	cysG	siroheme synthase	472	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	52.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00533 (show subtarget assignments)	1	purified	YPO0158	16120501	cysG	siroheme synthase	470	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	70.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02022 (show subtarget assignments)	1	expressed	CBU_1351	29541916	folP	dihydropteroate synthase [Coxiella burne...	297	Conserved; Drug target functions	Phase 3: June 2008	3TR9	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00527 (show subtarget assignments)	1	purified	YPO0129	16120472	bioH	putative biotin biosynthesis protein	258	Drug Target Function	Phase 2: March 2008	1M33	63.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02735 (show subtarget assignments)	1	soluble	GBAA4334	47529631	ribH	riboflavin synthase subunit beta [Bacill...	153	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VSW	100%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00995 (show subtarget assignments)	1	in_pdb 3H02	STM2307	16765634	menB	naphthoate synthase	285	Conserved Gene / Pathway	Phase 2: March 2008	3H02	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00994 (show subtarget assignments)	1	in_pdb 3GC2	STM2306	16765633	menC	O-succinylbenzoate synthase	320	Conserved Gene / Pathway	Phase 2: March 2008	3GC2	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02423 (show subtarget assignments)	1	cloned	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00991 (show subtarget assignments)	1	purified	STM2212	16765541	yeiR	putative cobalamin biosynthetic protein ...	328	Conserved Gene / Pathway	Phase 2: March 2008	1NIJ	18.9%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02424 (show subtarget assignments)	1	cloned	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00990 (show subtarget assignments)	0	work_stopped	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01647 (show subtarget assignments)	1	expressed	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	Phase 3: June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00987 (show subtarget assignments)	1	soluble	STM2147	16765476	thiM	hydroxyethylthiazole kinase	265	Conserved Gene / Pathway	Phase 2: March 2008	1C3Q	36.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00521 (show subtarget assignments)	1	purified	YPO3180	16123342	thiL	thiamine monophosphate kinase	329	Conserved Gene / Pathway	Phase 2: March 2008	3MCQ	41.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02416 (show subtarget assignments)	1	purified	FTT1259	56708321	nadE	NH(3)-dependent NAD(+) synthetase [Franc...	249	Conserved; Drug target functions	Phase 3: June 2008	3FIU	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00520 (show subtarget assignments)	1	in_pdb 3F6M 3FPI	YPO3360	16123510	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	162	Conserved Gene / Pathway	Phase 2: March 2008	3F6M	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02629 (show subtarget assignments)	1	purified	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00979 (show subtarget assignments)	1	purified	STM1953	16765291	yedO	D-cysteine desulfhydrase	328	Conserved Gene / Pathway	Phase 2: March 2008	1J0A	38.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00974 (show subtarget assignments)	1	purified	STM1775	16765116	hemK	N5-glutamine S-adenosyl-L-methionine-dep...	277	Essential Gene	Phase 2: March 2008	1T43	76.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02017 (show subtarget assignments)	1	soluble	FTT0047	56707226	hemE	uroporphyrinogen decarboxylase [Francise...	344	Conserved; Drug target functions	Phase 3: June 2008	3CYV	47.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00969 (show subtarget assignments)	1	purified	STM1597	161353598	ydcW	putative aldehyde dehydrogenase	474	Conserved Gene / Pathway	Phase 2: March 2008	1WNB	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00960 (show subtarget assignments)	1	in_pdb 3HMQ	STM1310	16764661	nadE	NAD synthetase	275	Drug Target Function	Phase 2: March 2008	3HMQ	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01450 (show subtarget assignments)	1	purified	VC2269	15642267		3,4-dihydroxy-2-butanone 4-phosphate syn...	369	Drug Target Function	Phase 2: March 2008	1G57	30.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01704 (show subtarget assignments)	1	expressed	GBAA5215	47530521		aminotransferase, class V [Bacillus anth...	406	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T3I	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00501 (show subtarget assignments)	1	purified	YPO0922	16121227	epd	D-erythrose 4-phosphate dehydrogenase	338	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	82.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00499 (show subtarget assignments)	1	in_pdb 3IIE	YPO1048	16121348	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	398	Conserved Gene / Pathway	Phase 2: March 2008	3IIE	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00941 (show subtarget assignments)	1	purified	STM0846	16764208	moeA	molybdopterin biosynthesis protein MoeA ...	413	Conserved Gene / Pathway	Phase 2: March 2008	1FC5	87.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP00940 (show subtarget assignments)	1	soluble	STM0845	16764207	moeB	molybdopterin biosynthesis protein MoeB ...	249	Conserved Gene / Pathway	Phase 2: March 2008	1JW9	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP00937 (show subtarget assignments)	1	cloned	STM0795	16764158	bioF	8-amino-7-oxononanoate synthase	385	Conserved Gene / Pathway	Phase 2: March 2008	1BS0	80%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00936 (show subtarget assignments)	1	soluble	STM0793	16764156	bioA	adenosylmethionine--8-amino-7-oxononanoa...	429	Conserved Gene / Pathway	Phase 2: March 2008	1MLY	86.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02624 (show subtarget assignments)	1	soluble	FTT1562	56708589	ispA	geranyltranstransferase [Francisella tul...	293	Conserved; Drug target functions	Phase 3: June 2008	2FOR	40.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02099 (show subtarget assignments)	1	cloned	FTT0972	56708065		ABC transporter, ATP-binding protein [Fr...	249	Conserved; Drug target functions	Phase 3: June 2008	2D3W	57.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00932 (show subtarget assignments)	1	purified	STM0645	16764022	nadD	nicotinic acid mononucleotide adenyltran...	213	Conserved Gene / Pathway	Phase 2: March 2008	1K4K	85.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00927 (show subtarget assignments)	1	soluble	STM0598	16763975	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2FWM	89.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00926 (show subtarget assignments)	1	soluble	STM0597	16763974	entB	2,3-dihydro-2,3-dihydroxybenzoate synthe...	285	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	88.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00925 (show subtarget assignments)	1	crystallized	STM0595	16763972	entC	isochorismate synthase	391	Drug Target Function	Phase 2: March 2008	3HWO	84.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01882 (show subtarget assignments)	1	soluble	FTT0927	56708027	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	431	Drug Target	Phase 3: June 2008	2GSA	53.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01436 (show subtarget assignments)	1	crystallized	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00920 (show subtarget assignments)	1	purified	STM0417	16763797	ribH	riboflavin synthase subunit beta	156	Conserved Gene / Pathway	Phase 2: March 2008	3MK3	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00918 (show subtarget assignments)	1	soluble	STM0372	16763752	hemB	delta-aminolevulinic acid dehydratase	324	Conserved Gene / Pathway	Phase 2: March 2008	1I8J	93.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01953 (show subtarget assignments)	1	soluble	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02089 (show subtarget assignments)	1	cloned	CBU_0424	29541033	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	266	Conserved; Drug target functions	Phase 3: June 2008	1OY0	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00914 (show subtarget assignments)	1	soluble	STM0220	16763610	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	398	Conserved Gene / Pathway	Phase 2: March 2008	1K5H	88.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02012 (show subtarget assignments)	1	soluble	STM4233	16767483	ubiC	chorismate pyruvate lyase [Salmonella ty...	165	Conserved; Drug target functions	Phase 3: June 2008	1G1B	86.1%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00907 (show subtarget assignments)	1	purified	STM0140	16763530	coaE	dephospho-CoA kinase	206	Conserved Gene / Pathway	Phase 2: March 2008	1N3B	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00902 (show subtarget assignments)	1	expressed	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00479 (show subtarget assignments)	1	in_pdb 3H07	YPO0658	16120983	ribB	3,4-dihydroxy-2-butanone 4-phosphate syn...	217	Conserved Gene / Pathway	Phase 2: March 2008	3H07	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01875 (show subtarget assignments)	1	expressed	GBAA0069	47525323	pabA-1	para-aminobenzoate/anthranilate synthase...	195	Conserved; Essential; Drug target functions	Phase 3: June 2008	1QDL	45.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00895 (show subtarget assignments)	1	in_pdb 3IR4	STM1165	16764521	grxB	glutaredoxin 2	215	Conserved Gene / Pathway	Phase 2: March 2008	3IR4	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP01415 (show subtarget assignments)	1	purified	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02356 (show subtarget assignments)	1	cloned	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01692 (show subtarget assignments)	1	cloned	FTT1671	56708681	ribD	riboflavin biosynthesis protein ribD [Fr...	355	Conserved; Drug target functions	Phase 3: June 2008	2B3Z	37.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02019 (show subtarget assignments)	1	cloned	CBU_1182	29541752	iscS	cysteine desulfurase [Coxiella burnetii ...	380	Conserved; Drug target functions	Phase 3: June 2008	1P3W	43.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00875 (show subtarget assignments)	1	in_pdb 3G0M	STM1374	16764724	ynhA	cysteine desufuration protein SufE	138	Conserved Gene / Pathway	Phase 2: March 2008	3G0M	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01663 (show subtarget assignments)	1	purified	GBAA4696	47529995	hemC	porphobilinogen deaminase [Bacillus anth...	309	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02106 (show subtarget assignments)	1	cloned	FTT0654	56707776	elbB	isoprenoid biosynthesis protein [Francis...	219	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OY1	47.5%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00867 (show subtarget assignments)	1	purified	STM3730	161353581	dfp	phosphopantothenoylcysteine synthase/dec...	406	Essential Gene	Phase 2: March 2008	1U7U	50.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01850 (show subtarget assignments)	1	cloned	FTT0916c	56708017	ribF	riboflavin biosynthesis protein RibF [Fr...	306	Drug Target	Phase 3: June 2008	1MRZ	30.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02324 (show subtarget assignments)	1	purified	FTT0581	56707709	coaD	phosphopantetheine adenylyltransferase [...	162	Conserved; Drug target functions	Phase 3: June 2008	1VLH	50.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01232 (show subtarget assignments)	1	purified	BA_5112	30259596	menF	menaquinone-specific isochorismate synth...	464	Drug Target Function	Phase 2: March 2008	3H9M	22.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02537 (show subtarget assignments)	0	work_stopped	GBAA4558	47778307	nadD	nicotinic acid mononucleotide adenylyltr...	171	Conserved; Drug target functions	Phase 3: June 2008	2QTM	99.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00092 (show subtarget assignments)	1	expressed	NT01SF0466	30040219	hemH	ferrochelatase	320	Essential	Phase 1: October 2007	1L8X	27.9%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02291 (show subtarget assignments)	1	cloned	FTT0167	56707337	hemA	glutamyl-tRNA reductase [Francisella tul...	416	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	26.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01839 (show subtarget assignments)	1	purified	GBAA1563	47526836	panC	pantoate--beta-alanine ligase [Bacillus ...	282	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2X3F	53.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02289 (show subtarget assignments)	1	in_pdb 3OF5	FTT0934c	56708031	bioD	dethiobiotin synthetase [Francisella tul...	225	Conserved; Drug target functions	Phase 3: June 2008	3OF5	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02530 (show subtarget assignments)	1	soluble	FTT1674	56708684	ribH	riboflavin synthase beta subunit (6,7-di...	147	Conserved; Drug target functions	Phase 3: June 2008	1RVV	45.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00091 (show subtarget assignments)	0	work_stopped	NTL01SF0342	30040153	ribD	bifunctional pyrimidine deaminase/reduct...	367	Essential	Phase 1: October 2007	2G6V	97.8%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00439 (show subtarget assignments)	1	in_pdb 3F4N	YPO2930	16123117	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Virulence Associated Factor	Phase 2: March 2008	3F4N	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02280 (show subtarget assignments)	1	in_pdb 3L44	GBAA0531	47525801	hemL-1	glutamate-1-semialdehyde aminotransferas...	434	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L44	99.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04719 (show subtarget assignments)	1	expressed	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04735 (show subtarget assignments)	1	purified	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP00089 (show subtarget assignments)	0	work_stopped	NT01ST0526	16418927	dxs	1-deoxyxylulose-5-phosphate synthase; fl...	620	Essential	Phase 1: October 2007	2O1S	96.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04687 (show subtarget assignments)	1	purified	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04688 (show subtarget assignments)	1	soluble	GBAA4661	47529959	nadC	nicotinate-nucleotide pyrophosphorylase ...	277	putative drug target function;	Phase 4: April 2009	1X1O	43.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02607 (show subtarget assignments)	1	expressed	CBU_0101	29540723	nadB	L-aspartate oxidase [Coxiella burnetii R...	536	Conserved; Drug target functions	Phase 3: June 2008	1CHU	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP04676 (show subtarget assignments)	1	soluble	GBAA2370	47527665	dhbE	2,3-dihydroxybenzoate-AMP ligase [Bacill...	538	putative drug target function;	Phase 4: April 2009	1MD9	71.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02332 (show subtarget assignments)	1	purified	GBAA1462	47526735		UbiE/COQ5 family methlytransferase [Baci...	258	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UJD	22.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01835 (show subtarget assignments)	1	cloned	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02083 (show subtarget assignments)	1	cloned	FTT1044c	56708131	ispB	octaprenyl-diphosphate synthase [Francis...	325	Drug Target	Phase 3: June 2008	3OYR	43.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04677 (show subtarget assignments)	1	soluble	GBAA2371	47527666	dhbB	isochorismatase [Bacillus anthracis str....	295	putative drug target function;	Phase 4: April 2009	2FQ1	45.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02073 (show subtarget assignments)	1	expressed	CBU_0418	29541027		4-amino-4-deoxychorismate lyase, putativ...	281	Conserved; Drug target functions	Phase 3: June 2008	3LUL	28.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02260 (show subtarget assignments)	1	purified	GBAA0072	47777774	folB	dihydroneopterin aldolase [Bacillus anth...	120	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1DHN	43.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04545 (show subtarget assignments)	1	purified	CPF_1198	110801283		glutathione peroxidase [Clostridium perf...	178	drug target; putative drug target function;	Phase 4: April 2009	3CMI	48.3%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP00424 (show subtarget assignments)	1	soluble	YPO2975	16123156		aminotransferase	411	Conserved Gene / Pathway	Phase 2: March 2008	2X5D	88.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04513 (show subtarget assignments)	1	purified	CPF_2363	110799064		putative thiamin biosynthesis lipoprotei...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1VRM	29.2%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02257 (show subtarget assignments)	1	expressed	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01225 (show subtarget assignments)	1	purified	BA_4139	61211625		Phosphopantetheine adenylyltransferase (...	163	Drug Target Function	Phase 2: March 2008	1O6B	71.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01820 (show subtarget assignments)	1	cloned	GBAA5463	47530777	thiC	thiamine biosynthesis protein ThiC [Baci...	586	Conserved; Drug target functions	Phase 3: June 2008	3EPM	66.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04503 (show subtarget assignments)	1	cloned	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04494 (show subtarget assignments)	1	expressed	VC0591	15640612	panC	pantoate--beta-alanine ligase [Vibrio ch...	293	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3Q10	57%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04504 (show subtarget assignments)	1	cloned	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04485 (show subtarget assignments)	1	purified	YPO3430	115349058		conserved hypothetical protein [Yersinia...	206	conserved gene; putative drug target function;	Phase 4: April 2009	1N3B	62.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01828 (show subtarget assignments)	1	in_pdb 3NZT	FTT0367c	56707518	gshA	glutamate--cysteine ligase [Francisella ...	501	Drug Target	Phase 3: June 2008	3NZT	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP01044
(show subtarget assignments)

1

soluble

STM3070

16766371

epd

D-erythrose 4-phosphate dehydrogenase

348

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

91.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01043
(show subtarget assignments)

1

soluble

STM2985

16766289

ygdK

putative FeS center assembly protein

147

Conserved Gene / Pathway

Phase 2: March 2008

1NI7

86.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01038
(show subtarget assignments)

1

in_pdb
3GHZ

STM2929

16766235

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

159

Drug Target Function

Phase 2: March 2008

3GHZ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01034
(show subtarget assignments)

0

work_stopped

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02662
(show subtarget assignments)

1

purified

lmo1676

16803716

menF

menaquinone-specific isochorismate synth...

462

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3HWO

23.6%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00230
(show subtarget assignments)

1

purified

YPO3444

16123592

-

putative acetyltransferase

167

Virulence

Phase 1: October 2007

2GE3

18%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01012
(show subtarget assignments)

1

purified

STM2578

16765898

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Conserved Gene / Pathway

Phase 2: March 2008

1M5W

93.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00534
(show subtarget assignments)

1

purified

YPO3367

16123517

cysG

siroheme synthase

472

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

52.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00533
(show subtarget assignments)

1

purified

YPO0158

16120501

cysG

siroheme synthase

470

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

70.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02022
(show subtarget assignments)

1

expressed

CBU_1351

29541916

folP

dihydropteroate synthase [Coxiella burne...

297

Conserved; Drug target functions

Phase 3: June 2008

3TR9

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00527
(show subtarget assignments)

1

purified

YPO0129

16120472

bioH

putative biotin biosynthesis protein

258

Drug Target Function

Phase 2: March 2008

1M33

63.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02735
(show subtarget assignments)

1

soluble

GBAA4334

47529631

ribH

riboflavin synthase subunit beta [Bacill...

153

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VSW

100%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00995
(show subtarget assignments)

1

in_pdb
3H02

STM2307

16765634

menB

naphthoate synthase

285

Conserved Gene / Pathway

Phase 2: March 2008

3H02

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00994
(show subtarget assignments)

1

in_pdb
3GC2

STM2306

16765633

menC

O-succinylbenzoate synthase

320

Conserved Gene / Pathway

Phase 2: March 2008

3GC2

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02423
(show subtarget assignments)

1

cloned

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00991
(show subtarget assignments)

1

purified

STM2212

16765541

yeiR

putative cobalamin biosynthetic protein ...

328

Conserved Gene / Pathway

Phase 2: March 2008

1NIJ

18.9%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02424
(show subtarget assignments)

1

cloned

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00990
(show subtarget assignments)

0

work_stopped

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01647
(show subtarget assignments)

1

expressed

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

Phase 3: June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00987
(show subtarget assignments)

1

soluble

STM2147

16765476

thiM

hydroxyethylthiazole kinase

265

Conserved Gene / Pathway

Phase 2: March 2008

1C3Q

36.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00521
(show subtarget assignments)

1

purified

YPO3180

16123342

thiL

thiamine monophosphate kinase

329

Conserved Gene / Pathway

Phase 2: March 2008

3MCQ

41.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02416
(show subtarget assignments)

1

purified

FTT1259

56708321

nadE

NH(3)-dependent NAD(+) synthetase [Franc...

249

Conserved; Drug target functions

Phase 3: June 2008

3FIU

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00520
(show subtarget assignments)

1

in_pdb
3F6M
3FPI

YPO3360

16123510

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

162

Conserved Gene / Pathway

Phase 2: March 2008

3F6M

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02629
(show subtarget assignments)

1

purified

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00979
(show subtarget assignments)

1

purified

STM1953

16765291

yedO

D-cysteine desulfhydrase

328

Conserved Gene / Pathway

Phase 2: March 2008

1J0A

38.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00974
(show subtarget assignments)

1

purified

STM1775

16765116

hemK

N5-glutamine S-adenosyl-L-methionine-dep...

277

Essential Gene

Phase 2: March 2008

1T43

76.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02017
(show subtarget assignments)

1

soluble

FTT0047

56707226

hemE

uroporphyrinogen decarboxylase [Francise...

344

Conserved; Drug target functions

Phase 3: June 2008

3CYV

47.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00969
(show subtarget assignments)

1

purified

STM1597

161353598

ydcW

putative aldehyde dehydrogenase

474

Conserved Gene / Pathway

Phase 2: March 2008

1WNB

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00960
(show subtarget assignments)

1

in_pdb
3HMQ

STM1310

16764661

nadE

NAD synthetase

275

Drug Target Function

Phase 2: March 2008

3HMQ

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01450
(show subtarget assignments)

1

purified

VC2269

15642267

3,4-dihydroxy-2-butanone 4-phosphate syn...

369

Drug Target Function

Phase 2: March 2008

1G57

30.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01704
(show subtarget assignments)

1

expressed

GBAA5215

47530521

aminotransferase, class V [Bacillus anth...

406

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T3I

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00501
(show subtarget assignments)

1

purified

YPO0922

16121227

epd

D-erythrose 4-phosphate dehydrogenase

338

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

82.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00499
(show subtarget assignments)

1

in_pdb
3IIE

YPO1048

16121348

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

398

Conserved Gene / Pathway

Phase 2: March 2008

3IIE

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00941
(show subtarget assignments)

1

purified

STM0846

16764208

moeA

molybdopterin biosynthesis protein MoeA ...

413

Conserved Gene / Pathway

Phase 2: March 2008

1FC5

87.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP00940
(show subtarget assignments)

1

soluble

STM0845

16764207

moeB

molybdopterin biosynthesis protein MoeB ...

249

Conserved Gene / Pathway

Phase 2: March 2008

1JW9

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP00937
(show subtarget assignments)

1

cloned

STM0795

16764158

bioF

8-amino-7-oxononanoate synthase

385

Conserved Gene / Pathway

Phase 2: March 2008

1BS0

80%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00936
(show subtarget assignments)

1

soluble

STM0793

16764156

bioA

adenosylmethionine--8-amino-7-oxononanoa...

429

Conserved Gene / Pathway

Phase 2: March 2008

1MLY

86.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02624
(show subtarget assignments)

1

soluble

FTT1562

56708589

ispA

geranyltranstransferase [Francisella tul...

293

Conserved; Drug target functions

Phase 3: June 2008

2FOR

40.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02099
(show subtarget assignments)

1

cloned

FTT0972

56708065

ABC transporter, ATP-binding protein [Fr...

249

Conserved; Drug target functions

Phase 3: June 2008

2D3W

57.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00932
(show subtarget assignments)

1

purified

STM0645

16764022

nadD

nicotinic acid mononucleotide adenyltran...

213

Conserved Gene / Pathway

Phase 2: March 2008

1K4K

85.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00927
(show subtarget assignments)

1

soluble

STM0598

16763975

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2FWM

89.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00926
(show subtarget assignments)

1

soluble

STM0597

16763974

entB

2,3-dihydro-2,3-dihydroxybenzoate synthe...

285

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

88.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00925
(show subtarget assignments)

1

crystallized

STM0595

16763972

entC

isochorismate synthase

391

Drug Target Function

Phase 2: March 2008

3HWO

84.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01882
(show subtarget assignments)

1

soluble

FTT0927

56708027

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

431

Drug Target

Phase 3: June 2008

2GSA

53.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01436
(show subtarget assignments)

1

crystallized

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00920
(show subtarget assignments)

1

purified

STM0417

16763797

ribH

riboflavin synthase subunit beta

156

Conserved Gene / Pathway

Phase 2: March 2008

3MK3

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00918
(show subtarget assignments)

1

soluble

STM0372

16763752

hemB

delta-aminolevulinic acid dehydratase

324

Conserved Gene / Pathway

Phase 2: March 2008

1I8J

93.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01953
(show subtarget assignments)

1

soluble

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02089
(show subtarget assignments)

1

cloned

CBU_0424

29541033

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

266

Conserved; Drug target functions

Phase 3: June 2008

1OY0

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00914
(show subtarget assignments)

1

soluble

STM0220

16763610

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

398

Conserved Gene / Pathway

Phase 2: March 2008

1K5H

88.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02012
(show subtarget assignments)

1

soluble

STM4233

16767483

ubiC

chorismate pyruvate lyase [Salmonella ty...

165

Conserved; Drug target functions

Phase 3: June 2008

1G1B

86.1%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00907
(show subtarget assignments)

1

purified

STM0140

16763530

coaE

dephospho-CoA kinase

206

Conserved Gene / Pathway

Phase 2: March 2008

1N3B

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00902
(show subtarget assignments)

1

expressed

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00479
(show subtarget assignments)

1

in_pdb
3H07

YPO0658

16120983

ribB

3,4-dihydroxy-2-butanone 4-phosphate syn...

217

Conserved Gene / Pathway

Phase 2: March 2008

3H07

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01875
(show subtarget assignments)

1

expressed

GBAA0069

47525323

pabA-1

para-aminobenzoate/anthranilate synthase...

195

Conserved; Essential; Drug target functions

Phase 3: June 2008

1QDL

45.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00895
(show subtarget assignments)

1

in_pdb
3IR4

STM1165

16764521

grxB

glutaredoxin 2

215

Conserved Gene / Pathway

Phase 2: March 2008

3IR4

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP01415
(show subtarget assignments)

1

purified

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02356
(show subtarget assignments)

1

cloned

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01692
(show subtarget assignments)

1

cloned

FTT1671

56708681

ribD

riboflavin biosynthesis protein ribD [Fr...

355

Conserved; Drug target functions

Phase 3: June 2008

2B3Z

37.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02019
(show subtarget assignments)

1

cloned

CBU_1182

29541752

iscS

cysteine desulfurase [Coxiella burnetii ...

380

Conserved; Drug target functions

Phase 3: June 2008

1P3W

43.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00875
(show subtarget assignments)

1

in_pdb
3G0M

STM1374

16764724

ynhA

cysteine desufuration protein SufE

138

Conserved Gene / Pathway

Phase 2: March 2008

3G0M

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01663
(show subtarget assignments)

1

purified

GBAA4696

47529995

hemC

porphobilinogen deaminase [Bacillus anth...

309

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02106
(show subtarget assignments)

1

cloned

FTT0654

56707776

elbB

isoprenoid biosynthesis protein [Francis...

219

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OY1

47.5%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00867
(show subtarget assignments)

1

purified

STM3730

161353581

dfp

phosphopantothenoylcysteine synthase/dec...

406

Essential Gene

Phase 2: March 2008

1U7U

50.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01850
(show subtarget assignments)

1

cloned

FTT0916c

56708017

ribF

riboflavin biosynthesis protein RibF [Fr...

306

Drug Target

Phase 3: June 2008

1MRZ

30.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02324
(show subtarget assignments)

1

purified

FTT0581

56707709

coaD

phosphopantetheine adenylyltransferase [...

162

Conserved; Drug target functions

Phase 3: June 2008

1VLH

50.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01232
(show subtarget assignments)

1

purified

BA_5112

30259596

menF

menaquinone-specific isochorismate synth...

464

Drug Target Function

Phase 2: March 2008

3H9M

22.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02537
(show subtarget assignments)

0

work_stopped

GBAA4558

47778307

nadD

nicotinic acid mononucleotide adenylyltr...

171

Conserved; Drug target functions

Phase 3: June 2008

2QTM

99.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00092
(show subtarget assignments)

1

expressed

NT01SF0466

30040219

hemH

ferrochelatase

320

Essential

Phase 1: October 2007

1L8X

27.9%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02291
(show subtarget assignments)

1

cloned

FTT0167

56707337

hemA

glutamyl-tRNA reductase [Francisella tul...

416

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

26.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01839
(show subtarget assignments)

1

purified

GBAA1563

47526836

panC

pantoate--beta-alanine ligase [Bacillus ...

282

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2X3F

53.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02289
(show subtarget assignments)

1

in_pdb
3OF5

FTT0934c

56708031

bioD

dethiobiotin synthetase [Francisella tul...

225

Conserved; Drug target functions

Phase 3: June 2008

3OF5

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02530
(show subtarget assignments)

1

soluble

FTT1674

56708684

ribH

riboflavin synthase beta subunit (6,7-di...

147

Conserved; Drug target functions

Phase 3: June 2008

1RVV

45.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00091
(show subtarget assignments)

0

work_stopped

NTL01SF0342

30040153

ribD

bifunctional pyrimidine deaminase/reduct...

367

Essential

Phase 1: October 2007

2G6V

97.8%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00439
(show subtarget assignments)

1

in_pdb
3F4N

YPO2930

16123117

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Virulence Associated Factor

Phase 2: March 2008

3F4N

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02280
(show subtarget assignments)

1

in_pdb
3L44

GBAA0531

47525801

hemL-1

glutamate-1-semialdehyde aminotransferas...

434

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L44

99.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04719
(show subtarget assignments)

1

expressed

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04735
(show subtarget assignments)

1

purified

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP00089
(show subtarget assignments)

0

work_stopped

NT01ST0526

16418927

dxs

1-deoxyxylulose-5-phosphate synthase; fl...

620

Essential

Phase 1: October 2007

2O1S

96.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04687
(show subtarget assignments)

1

purified

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04688
(show subtarget assignments)

1

soluble

GBAA4661

47529959

nadC

nicotinate-nucleotide pyrophosphorylase ...

277

putative drug target function;

Phase 4: April 2009

1X1O

43.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02607
(show subtarget assignments)

1

expressed

CBU_0101

29540723

nadB

L-aspartate oxidase [Coxiella burnetii R...

536

Conserved; Drug target functions

Phase 3: June 2008

1CHU

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP04676
(show subtarget assignments)

1

soluble

GBAA2370

47527665

dhbE

2,3-dihydroxybenzoate-AMP ligase [Bacill...

538

putative drug target function;

Phase 4: April 2009

1MD9

71.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02332
(show subtarget assignments)

1

purified

GBAA1462

47526735

UbiE/COQ5 family methlytransferase [Baci...

258

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UJD

22.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01835
(show subtarget assignments)

1

cloned

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02083
(show subtarget assignments)

1

cloned

FTT1044c

56708131

ispB

octaprenyl-diphosphate synthase [Francis...

325

Drug Target

Phase 3: June 2008

3OYR

43.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04677
(show subtarget assignments)

1

soluble

GBAA2371

47527666

dhbB

isochorismatase [Bacillus anthracis str....

295

putative drug target function;

Phase 4: April 2009

2FQ1

45.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02073
(show subtarget assignments)

1

expressed

CBU_0418

29541027

4-amino-4-deoxychorismate lyase, putativ...

281

Conserved; Drug target functions

Phase 3: June 2008

3LUL

28.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02260
(show subtarget assignments)

1

purified

GBAA0072

47777774

folB

dihydroneopterin aldolase [Bacillus anth...

120

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1DHN

43.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04545
(show subtarget assignments)

1

purified

CPF_1198

110801283

glutathione peroxidase [Clostridium perf...

178

drug target; putative drug target function;

Phase 4: April 2009

3CMI

48.3%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP00424
(show subtarget assignments)

1

soluble

YPO2975

16123156

aminotransferase

411

Conserved Gene / Pathway

Phase 2: March 2008

2X5D

88.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04513
(show subtarget assignments)

1

purified

CPF_2363

110799064

putative thiamin biosynthesis lipoprotei...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1VRM

29.2%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02257
(show subtarget assignments)

1

expressed

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01225
(show subtarget assignments)

1

purified

BA_4139

61211625

Phosphopantetheine adenylyltransferase (...

163

Drug Target Function

Phase 2: March 2008

1O6B

71.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01820
(show subtarget assignments)

1

cloned

GBAA5463

47530777

thiC

thiamine biosynthesis protein ThiC [Baci...

586

Conserved; Drug target functions

Phase 3: June 2008

3EPM

66.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04503
(show subtarget assignments)

1

cloned

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04494
(show subtarget assignments)

1

expressed

VC0591

15640612

panC

pantoate--beta-alanine ligase [Vibrio ch...

293

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3Q10

57%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04504
(show subtarget assignments)

1

cloned

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04485
(show subtarget assignments)

1

purified

YPO3430

115349058

conserved hypothetical protein [Yersinia...

206

conserved gene; putative drug target function;

Phase 4: April 2009

1N3B

62.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01828
(show subtarget assignments)

1

in_pdb
3NZT

FTT0367c

56707518

gshA

glutamate--cysteine ligase [Francisella ...

501

Drug Target

Phase 3: June 2008

3NZT

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

Targets