Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02503 (show subtarget assignments)	1	cloned	YPO2502	16122723	gutB	putative zinc-binding dehydrogenase [Yer...	408	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	2D8A	30.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Chlorophyll and bacteriochlorphyll

IDP02520 (show subtarget assignments)	1	soluble	FTT0833	56707942	ispH	IspH protein [Francisella tularensis sub...	318	Drug Target	Phase 3: June 2008	3F7T	51.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00091 (show subtarget assignments)	0	work_stopped	NTL01SF0342	30040153	ribD	bifunctional pyrimidine deaminase/reduct...	367	Essential	Phase 1: October 2007	2G6V	97.8%	Shigella flexneri	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00439 (show subtarget assignments)	1	in_pdb 3F4N	YPO2930	16123117	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Virulence Associated Factor	Phase 2: March 2008	3F4N	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02777 (show subtarget assignments)	1	soluble	GBAA4698	47529997	hemA	glutamyl-tRNA reductase [Bacillus anthra...	444	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	27.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00089 (show subtarget assignments)	0	work_stopped	NT01ST0526	16418927	dxs	1-deoxyxylulose-5-phosphate synthase; fl...	620	Essential	Phase 1: October 2007	2O1S	96.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02543 (show subtarget assignments)	1	expressed	CBU_0275	29540889	hemE	uroporphyrinogen decarboxylase [Coxiella...	361	Conserved; Drug target functions	Phase 3: June 2008	3CYV	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02165 (show subtarget assignments)	1	soluble	CBU_1993	29542548	folA	dihydrofolate reductase [Coxiella burnet...	161	Conserved; Drug target functions	Phase 3: June 2008	3TQ8	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01619 (show subtarget assignments)	1	expressed	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02257 (show subtarget assignments)	1	expressed	CBU_2074	29542624	hemC	porphobilinogen deaminase [Coxiella burn...	307	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02260 (show subtarget assignments)	1	purified	GBAA0072	47777774	folB	dihydroneopterin aldolase [Bacillus anth...	120	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1DHN	43.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00424 (show subtarget assignments)	1	soluble	YPO2975	16123156		aminotransferase	411	Conserved Gene / Pathway	Phase 2: March 2008	2X5D	88.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP01615 (show subtarget assignments)	1	purified	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	Phase 3: June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01999 (show subtarget assignments)	1	soluble	FTT0942c	56708039	folK	2-amino-4-hydroxy-6-hydroxymethyldihydro...	421	Conserved; Drug target functions	Phase 3: June 2008	3MCM	99.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02157 (show subtarget assignments)	1	expressed	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01993 (show subtarget assignments)	1	cloned	lmo1476	16803516	hemN	coproporphyrinogen III oxidase [Listeria...	385	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	27.4%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00412 (show subtarget assignments)	1	expressed	YPO0169	16120512	pabA	para-aminobenzoate synthase component II...	191	Drug Target Function	Phase 2: March 2008	1QDL	46.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02462 (show subtarget assignments)	1	expressed	FTT1467c	56708507	nadB	L-aspartate oxidase [Francisella tularen...	495	Conserved; Drug target functions	Phase 3: June 2008	1CHU	38.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00746 (show subtarget assignments)	1	soluble	SACOL1717	57284728	hemC	porphobilinogen deaminase	308	Drug Target Function	Phase 2: March 2008	1PDA	45.1%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00745 (show subtarget assignments)	1	purified	SACOL1715	57284726	hemB	delta-aminolevulinic acid dehydratase	324	Drug Target Function	Phase 2: March 2008	1B4E	47.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02167 (show subtarget assignments)	1	expressed	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00402 (show subtarget assignments)	1	purified	YPO3182	16123344	ribH	riboflavin synthase subunit beta	156	Conserved Gene / Pathway	Phase 2: March 2008	3MK3	82.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01789 (show subtarget assignments)	0	work_stopped	Cj1613c	15792918		hypothetical protein Cj1613c [Campylobac...	251	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3SWJ	98.8%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00400 (show subtarget assignments)	0	work_stopped	YPO2222	16122451	ribA	GTP cyclohydrolase II	196	Virulence Associated Factor	Phase 2: March 2008	2BZ0	88.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00010 (show subtarget assignments)	1	purified	BA_2144	30256791		uroporphyrin-III C-methyltransferase, pu...	474	Drug Target Homolog	Phase 1: October 2007	1PJQ	24.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02242 (show subtarget assignments)	1	cloned	Cj0320	15791688	fliH	flagellar assembly protein H [Campylobac...	276	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02423 (show subtarget assignments)	1	cloned	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02424 (show subtarget assignments)	1	cloned	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04719 (show subtarget assignments)	1	expressed	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04735 (show subtarget assignments)	1	purified	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP01953 (show subtarget assignments)	1	soluble	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01958 (show subtarget assignments)	1	expressed	FTT0937c	56708034	bioB	biotin synthase [Francisella tularensis ...	313	Drug Target	Phase 3: June 2008	1R30	49.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01948 (show subtarget assignments)	1	purified	STM1931	16765272	araH	putative intracellular protease/amidase ...	185	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3B36	30.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02416 (show subtarget assignments)	1	purified	FTT1259	56708321	nadE	NH(3)-dependent NAD(+) synthetase [Franc...	249	Conserved; Drug target functions	Phase 3: June 2008	3FIU	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP04688 (show subtarget assignments)	1	soluble	GBAA4661	47529959	nadC	nicotinate-nucleotide pyrophosphorylase ...	277	putative drug target function;	Phase 4: April 2009	1X1O	43.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02771 (show subtarget assignments)	1	in_pdb 3N8H 3QTT	FTT1390	56708439	panC	pantoate-beta-alanine ligase [Francisell...	261	Conserved; Drug target functions	Phase 3: June 2008	3N8H	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00333 (show subtarget assignments)	1	crystallized	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04676 (show subtarget assignments)	1	soluble	GBAA2370	47527665	dhbE	2,3-dihydroxybenzoate-AMP ligase [Bacill...	538	putative drug target function;	Phase 4: April 2009	1MD9	71.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04666 (show subtarget assignments)	1	purified	GBAA1158	47526425	hemH-2	ferrochelatase [Bacillus anthracis str. ...	319	putative drug target function;	Phase 4: April 2009	2C8J	62.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01985 (show subtarget assignments)	1	expressed	CBU_1882	29542439	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	435	Conserved; Drug target functions	Phase 3: June 2008	3K28	52.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00332 (show subtarget assignments)	1	purified	FTT1673	56708683	ribA	riboflavin biosynthesis protein ribA/GTP...	403	Drug Target Function	Phase 2: March 2008	1G57	27%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02137 (show subtarget assignments)	1	soluble	Cj0547	15791908	flaG	flagellar protein FlaG [Campylobacter je...	121	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00331 (show subtarget assignments)	1	in_pdb 3RE3	FTT1128	56708205	ispF	2C-methyl-D-erythritol 2,4-cyclodiphosph...	159	Drug Target Function	Phase 2: March 2008	3RE3	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04513 (show subtarget assignments)	1	purified	CPF_2363	110799064		putative thiamin biosynthesis lipoprotei...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1VRM	29.2%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04545 (show subtarget assignments)	1	purified	CPF_1198	110801283		glutathione peroxidase [Clostridium perf...	178	drug target; putative drug target function;	Phase 4: April 2009	3CMI	48.3%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP02773 (show subtarget assignments)	1	crystallized	FTT1389	56708438	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	264	Conserved; Drug target functions	Phase 3: June 2008	1O66	41.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02823 (show subtarget assignments)	1	soluble	CBU_0382	29540992	ispB	octylprenyl diphosphate synthase-like pr...	332	Conserved; Drug target functions	Phase 3: June 2008	3MZV	44%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02776 (show subtarget assignments)	1	expressed	CBU_1266	29541836	lipA	lipoic acid synthetase [Coxiella burneti...	315	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP02834 (show subtarget assignments)	1	expressed	GBAA4975	47530273	moaC	molybdenum cofactor biosynthesis protein...	161	Conserved; Drug target functions	Phase 3: June 2008	2EEY	69.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP01450 (show subtarget assignments)	1	purified	VC2269	15642267		3,4-dihydroxy-2-butanone 4-phosphate syn...	369	Drug Target Function	Phase 2: March 2008	1G57	30.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04687 (show subtarget assignments)	1	purified	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04494 (show subtarget assignments)	1	expressed	VC0591	15640612	panC	pantoate--beta-alanine ligase [Vibrio ch...	293	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3Q10	57%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04485 (show subtarget assignments)	1	purified	YPO3430	115349058		conserved hypothetical protein [Yersinia...	206	conserved gene; putative drug target function;	Phase 4: April 2009	1N3B	62.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02800 (show subtarget assignments)	1	soluble	GBAA4828	47530124	coaE	dephospho-CoA kinase [Bacillus anthracis...	200	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JJV	43.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04483 (show subtarget assignments)	1	expressed	YPO3361	115348990	b2747	4-diphosphocytidyl-2C-methyl-D-erythrito...	241	conserved gene; putative drug target function;	Phase 4: April 2009	1VGT	63.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04471 (show subtarget assignments)	1	purified	YPO2370	218929461	pdxH	pyridoxamine 5'-phosphate oxidase [Yersi...	217	conserved gene; putative drug target function;	Phase 4: April 2009	1G76	78.4%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04474 (show subtarget assignments)	1	purified	YPO2763	218929835	pdxB	putative D-isomer specific 2-hydroxyacid...	375	drug target; putative drug target function;	Phase 4: April 2009	3OET	72.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP01926 (show subtarget assignments)	1	cloned	lmo0931	16802971		hypothetical protein lmo0931 [Listeria m...	331	Known virulence-Intracellular Survival; PMID:17908209	Phase 3: June 2008	1VQZ	44.7%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP04476 (show subtarget assignments)	1	cloned	YPO2773	115348456	ubiX	probable 3-octaprenyl-4-hydroxybenzoate ...	190	conserved gene; putative drug target function;	Phase 4: April 2009	1SBZ	51.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04469 (show subtarget assignments)	1	cloned	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00643 (show subtarget assignments)	1	soluble	SACOL2638	57286542		precorrin-2 dehydrogenase	201	Conserved Gene / Pathway	Phase 2: March 2008	3DFZ	33.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01232 (show subtarget assignments)	1	purified	BA_5112	30259596	menF	menaquinone-specific isochorismate synth...	464	Drug Target Function	Phase 2: March 2008	3H9M	22.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01735 (show subtarget assignments)	1	soluble	CBU_1129	29541703	nifS	cysteine desulfurase [Coxiella burnetii ...	396	Conserved; Drug target functions	Phase 3: June 2008	1P3W	57.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04503 (show subtarget assignments)	1	cloned	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00070 (show subtarget assignments)	0	work_stopped	NT01ST1465	16419700	flgK	hook-filament junction protein 1	553	Virulence	Phase 1: October 2007	2D4Y	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01225 (show subtarget assignments)	1	purified	BA_4139	61211625		Phosphopantetheine adenylyltransferase (...	163	Drug Target Function	Phase 2: March 2008	1O6B	71.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04452 (show subtarget assignments)	1	purified	YPO1049	42560001		RecName: Full=Undecaprenyl pyrophosphate...	252	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	76.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00017 (show subtarget assignments)	1	purified	BA_4333	81581445	ribBA	Riboflavin biosynthesis protein ribBA [I...	397	Drug Target Homolog	Phase 1: October 2007	2BZ0	27%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02356 (show subtarget assignments)	1	cloned	FTT1296	56708355	ubiE	menaquinone biosynthesis methyltransfera...	250	Conserved; Drug target functions	Phase 3: June 2008	2AVN	20%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00313 (show subtarget assignments)	1	expressed	CBU_0647	29653985	ribA	riboflavin biosynthesis protein RibA	406	Drug Target Function	Phase 2: March 2008	2BZ0	27.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04402 (show subtarget assignments)	1	cloned	VC2254	15642252		1-deoxy-D-xylulose 5-phosphate reductois...	402	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K5H	60.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01205 (show subtarget assignments)	1	in_pdb 3OS6	BA_2369	30257005	dhbC	isochorismate synthase DhbC	399	Drug Target Function	Phase 2: March 2008	3OS6	99.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04426 (show subtarget assignments)	1	expressed	GBAA4339	47529636	bioF	8-amino-7-oxononanoate synthase [Bacillu...	395	putative drug target function;	Phase 4: April 2009	3A2B	33.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04048 (show subtarget assignments)	1	purified	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04384 (show subtarget assignments)	1	in_pdb 3PZS	YPO2368	218929459	pdxY	pyridoxamine kinase [Yersinia pestis CO9...	286	conserved gene; putative drug target function;	Phase 4: April 2009	3PZS	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02227 (show subtarget assignments)	1	cloned	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04504 (show subtarget assignments)	1	cloned	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04677 (show subtarget assignments)	1	soluble	GBAA2371	47527666	dhbB	isochorismatase [Bacillus anthracis str....	295	putative drug target function;	Phase 4: April 2009	2FQ1	45.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00308 (show subtarget assignments)	1	soluble	CBU_0288	29653640	coaD	phosphopantetheine adenylyltransferase	159	Drug Target Function	Phase 2: March 2008	3IKZ	47.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02134 (show subtarget assignments)	1	soluble	CBU_0597	29541198		oxygen-independent coproporphyrinogen II...	375	Conserved; Drug target functions	Phase 3: June 2008	1OLT	20.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04342 (show subtarget assignments)	1	cloned	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01753 (show subtarget assignments)	1	expressed	CBU_0423	29541032	panC	pantoate--beta-alanine ligase [Coxiella ...	257	Conserved; Drug target functions	Phase 3: June 2008	3N8H	40.9%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00067 (show subtarget assignments)	1	in_pdb 3PFI	NT01CJ1369	6968796	ruvB	holliday junction DNA helicase [Campylob...	335	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3PFI	100%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01181 (show subtarget assignments)	1	purified	BA_0085	38372318		2-C-methyl-D-erythritol 2,4-cyclodiphosp...	158	Drug Target Function	Phase 2: March 2008	3F6M	64.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02213 (show subtarget assignments)	1	expressed	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04360 (show subtarget assignments)	1	purified	YPO2018	115347740		putative protoporphyrinogen oxidase [Yer...	276	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1T43	62.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02332 (show subtarget assignments)	1	purified	GBAA1462	47526735		UbiE/COQ5 family methlytransferase [Baci...	258	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UJD	22.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02324 (show subtarget assignments)	1	purified	FTT0581	56707709	coaD	phosphopantetheine adenylyltransferase [...	162	Conserved; Drug target functions	Phase 3: June 2008	1VLH	50.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00008 (show subtarget assignments)	1	purified	BA_1445	30255378	cysG	uroporphyrin-III C-methyltransferase	258	Drug Target Homolog	Phase 1: October 2007	1PJQ	43.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01436 (show subtarget assignments)	1	crystallized	VC1976	15641978		menaquinone-specific isochorismate synth...	435	Drug Target Function	Phase 2: March 2008	3GSE	42.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02217 (show subtarget assignments)	1	expressed	FTT1018c	56708107	dxs	1-deoxy-D-xylulose-5-phosphate synthase ...	615	Conserved; Drug target functions	Phase 3: June 2008	2O1S	56.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	OtherPyridoxine,Thiamine

IDP04374 (show subtarget assignments)	1	crystallized	YPO3501	218930515	folP	dihydropteroate synthase [Yersinia pesti...	277	conserved gene; putative drug target function;	Phase 4: April 2009	1AJ0	74.7%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01415 (show subtarget assignments)	1	purified	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02106 (show subtarget assignments)	1	cloned	FTT0654	56707776	elbB	isoprenoid biosynthesis protein [Francis...	219	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OY1	47.5%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04281 (show subtarget assignments)	1	cloned	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04298 (show subtarget assignments)	1	soluble	VCA0827	15601582	phhB	pterin-4-alpha-carbinolamine dehydratase...	109	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1RU0	33%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04322 (show subtarget assignments)	1	cloned	VC1001	15641016		folylpolyglutamate synthase/dihydrofolat...	421	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3N2A	53.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04313 (show subtarget assignments)	1	purified	GBAA2368	47527663	entA	2,3-dihydroxybenzoate-2,3-dehydrogenase ...	258	virulence factor; putative drug target function;	Phase 4: April 2009	2FWM	45.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01142 (show subtarget assignments)	1	expressed	BA_1249	30255198	pabA-2	para-aminobenzoate synthase glutamine am...	195	Drug Target Function	Phase 2: March 2008	1QDL	43.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01882 (show subtarget assignments)	1	soluble	FTT0927	56708027	hemL	glutamate-1-semialdehyde-2,1-aminomutase...	431	Drug Target	Phase 3: June 2008	2GSA	53.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02503
(show subtarget assignments)

1

cloned

YPO2502

16122723

gutB

putative zinc-binding dehydrogenase [Yer...

408

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

2D8A

30.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Chlorophyll and bacteriochlorphyll

IDP02520
(show subtarget assignments)

1

soluble

FTT0833

56707942

ispH

IspH protein [Francisella tularensis sub...

318

Drug Target

Phase 3: June 2008

3F7T

51.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00091
(show subtarget assignments)

0

work_stopped

NTL01SF0342

30040153

ribD

bifunctional pyrimidine deaminase/reduct...

367

Essential

Phase 1: October 2007

2G6V

97.8%

Shigella flexneri

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00439
(show subtarget assignments)

1

in_pdb
3F4N

YPO2930

16123117

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Virulence Associated Factor

Phase 2: March 2008

3F4N

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02777
(show subtarget assignments)

1

soluble

GBAA4698

47529997

hemA

glutamyl-tRNA reductase [Bacillus anthra...

444

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

27.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00089
(show subtarget assignments)

0

work_stopped

NT01ST0526

16418927

dxs

1-deoxyxylulose-5-phosphate synthase; fl...

620

Essential

Phase 1: October 2007

2O1S

96.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02543
(show subtarget assignments)

1

expressed

CBU_0275

29540889

hemE

uroporphyrinogen decarboxylase [Coxiella...

361

Conserved; Drug target functions

Phase 3: June 2008

3CYV

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02165
(show subtarget assignments)

1

soluble

CBU_1993

29542548

folA

dihydrofolate reductase [Coxiella burnet...

161

Conserved; Drug target functions

Phase 3: June 2008

3TQ8

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01619
(show subtarget assignments)

1

expressed

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02257
(show subtarget assignments)

1

expressed

CBU_2074

29542624

hemC

porphobilinogen deaminase [Coxiella burn...

307

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02260
(show subtarget assignments)

1

purified

GBAA0072

47777774

folB

dihydroneopterin aldolase [Bacillus anth...

120

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1DHN

43.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00424
(show subtarget assignments)

1

soluble

YPO2975

16123156

aminotransferase

411

Conserved Gene / Pathway

Phase 2: March 2008

2X5D

88.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP01615
(show subtarget assignments)

1

purified

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

Phase 3: June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01999
(show subtarget assignments)

1

soluble

FTT0942c

56708039

folK

2-amino-4-hydroxy-6-hydroxymethyldihydro...

421

Conserved; Drug target functions

Phase 3: June 2008

3MCM

99.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02157
(show subtarget assignments)

1

expressed

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01993
(show subtarget assignments)

1

cloned

lmo1476

16803516

hemN

coproporphyrinogen III oxidase [Listeria...

385

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

27.4%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00412
(show subtarget assignments)

1

expressed

YPO0169

16120512

pabA

para-aminobenzoate synthase component II...

191

Drug Target Function

Phase 2: March 2008

1QDL

46.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02462
(show subtarget assignments)

1

expressed

FTT1467c

56708507

nadB

L-aspartate oxidase [Francisella tularen...

495

Conserved; Drug target functions

Phase 3: June 2008

1CHU

38.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00746
(show subtarget assignments)

1

soluble

SACOL1717

57284728

hemC

porphobilinogen deaminase

308

Drug Target Function

Phase 2: March 2008

1PDA

45.1%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00745
(show subtarget assignments)

1

purified

SACOL1715

57284726

hemB

delta-aminolevulinic acid dehydratase

324

Drug Target Function

Phase 2: March 2008

1B4E

47.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02167
(show subtarget assignments)

1

expressed

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00402
(show subtarget assignments)

1

purified

YPO3182

16123344

ribH

riboflavin synthase subunit beta

156

Conserved Gene / Pathway

Phase 2: March 2008

3MK3

82.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01789
(show subtarget assignments)

0

work_stopped

Cj1613c

15792918

hypothetical protein Cj1613c [Campylobac...

251

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3SWJ

98.8%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00400
(show subtarget assignments)

0

work_stopped

YPO2222

16122451

ribA

GTP cyclohydrolase II

196

Virulence Associated Factor

Phase 2: March 2008

2BZ0

88.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00010
(show subtarget assignments)

1

purified

BA_2144

30256791

uroporphyrin-III C-methyltransferase, pu...

474

Drug Target Homolog

Phase 1: October 2007

1PJQ

24.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02242
(show subtarget assignments)

1

cloned

Cj0320

15791688

fliH

flagellar assembly protein H [Campylobac...

276

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02423
(show subtarget assignments)

1

cloned

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02424
(show subtarget assignments)

1

cloned

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04719
(show subtarget assignments)

1

expressed

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04735
(show subtarget assignments)

1

purified

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP01953
(show subtarget assignments)

1

soluble

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01958
(show subtarget assignments)

1

expressed

FTT0937c

56708034

bioB

biotin synthase [Francisella tularensis ...

313

Drug Target

Phase 3: June 2008

1R30

49.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01948
(show subtarget assignments)

1

purified

STM1931

16765272

araH

putative intracellular protease/amidase ...

185

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3B36

30.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02416
(show subtarget assignments)

1

purified

FTT1259

56708321

nadE

NH(3)-dependent NAD(+) synthetase [Franc...

249

Conserved; Drug target functions

Phase 3: June 2008

3FIU

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP04688
(show subtarget assignments)

1

soluble

GBAA4661

47529959

nadC

nicotinate-nucleotide pyrophosphorylase ...

277

putative drug target function;

Phase 4: April 2009

1X1O

43.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02771
(show subtarget assignments)

1

in_pdb
3N8H
3QTT

FTT1390

56708439

panC

pantoate-beta-alanine ligase [Francisell...

261

Conserved; Drug target functions

Phase 3: June 2008

3N8H

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00333
(show subtarget assignments)

1

crystallized

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04676
(show subtarget assignments)

1

soluble

GBAA2370

47527665

dhbE

2,3-dihydroxybenzoate-AMP ligase [Bacill...

538

putative drug target function;

Phase 4: April 2009

1MD9

71.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04666
(show subtarget assignments)

1

purified

GBAA1158

47526425

hemH-2

ferrochelatase [Bacillus anthracis str. ...

319

putative drug target function;

Phase 4: April 2009

2C8J

62.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01985
(show subtarget assignments)

1

expressed

CBU_1882

29542439

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

435

Conserved; Drug target functions

Phase 3: June 2008

3K28

52.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00332
(show subtarget assignments)

1

purified

FTT1673

56708683

ribA

riboflavin biosynthesis protein ribA/GTP...

403

Drug Target Function

Phase 2: March 2008

1G57

27%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02137
(show subtarget assignments)

1

soluble

Cj0547

15791908

flaG

flagellar protein FlaG [Campylobacter je...

121

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00331
(show subtarget assignments)

1

in_pdb
3RE3

FTT1128

56708205

ispF

2C-methyl-D-erythritol 2,4-cyclodiphosph...

159

Drug Target Function

Phase 2: March 2008

3RE3

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04513
(show subtarget assignments)

1

purified

CPF_2363

110799064

putative thiamin biosynthesis lipoprotei...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1VRM

29.2%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04545
(show subtarget assignments)

1

purified

CPF_1198

110801283

glutathione peroxidase [Clostridium perf...

178

drug target; putative drug target function;

Phase 4: April 2009

3CMI

48.3%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP02773
(show subtarget assignments)

1

crystallized

FTT1389

56708438

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

264

Conserved; Drug target functions

Phase 3: June 2008

1O66

41.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02823
(show subtarget assignments)

1

soluble

CBU_0382

29540992

ispB

octylprenyl diphosphate synthase-like pr...

332

Conserved; Drug target functions

Phase 3: June 2008

3MZV

44%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02776
(show subtarget assignments)

1

expressed

CBU_1266

29541836

lipA

lipoic acid synthetase [Coxiella burneti...

315

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP02834
(show subtarget assignments)

1

expressed

GBAA4975

47530273

moaC

molybdenum cofactor biosynthesis protein...

161

Conserved; Drug target functions

Phase 3: June 2008

2EEY

69.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP01450
(show subtarget assignments)

1

purified

VC2269

15642267

3,4-dihydroxy-2-butanone 4-phosphate syn...

369

Drug Target Function

Phase 2: March 2008

1G57

30.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04687
(show subtarget assignments)

1

purified

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04494
(show subtarget assignments)

1

expressed

VC0591

15640612

panC

pantoate--beta-alanine ligase [Vibrio ch...

293

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3Q10

57%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04485
(show subtarget assignments)

1

purified

YPO3430

115349058

conserved hypothetical protein [Yersinia...

206

conserved gene; putative drug target function;

Phase 4: April 2009

1N3B

62.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02800
(show subtarget assignments)

1

soluble

GBAA4828

47530124

coaE

dephospho-CoA kinase [Bacillus anthracis...

200

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JJV

43.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04483
(show subtarget assignments)

1

expressed

YPO3361

115348990

b2747

4-diphosphocytidyl-2C-methyl-D-erythrito...

241

conserved gene; putative drug target function;

Phase 4: April 2009

1VGT

63.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04471
(show subtarget assignments)

1

purified

YPO2370

218929461

pdxH

pyridoxamine 5'-phosphate oxidase [Yersi...

217

conserved gene; putative drug target function;

Phase 4: April 2009

1G76

78.4%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP04474
(show subtarget assignments)

1

purified

YPO2763

218929835

pdxB

putative D-isomer specific 2-hydroxyacid...

375

drug target; putative drug target function;

Phase 4: April 2009

3OET

72.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP01926
(show subtarget assignments)

1

cloned

lmo0931

16802971

hypothetical protein lmo0931 [Listeria m...

331

Known virulence-Intracellular Survival; PMID:17908209

Phase 3: June 2008

1VQZ

44.7%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP04476
(show subtarget assignments)

1

cloned

YPO2773

115348456

ubiX

probable 3-octaprenyl-4-hydroxybenzoate ...

190

conserved gene; putative drug target function;

Phase 4: April 2009

1SBZ

51.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04469
(show subtarget assignments)

1

cloned

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00643
(show subtarget assignments)

1

soluble

SACOL2638

57286542

precorrin-2 dehydrogenase

201

Conserved Gene / Pathway

Phase 2: March 2008

3DFZ

33.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01232
(show subtarget assignments)

1

purified

BA_5112

30259596

menF

menaquinone-specific isochorismate synth...

464

Drug Target Function

Phase 2: March 2008

3H9M

22.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01735
(show subtarget assignments)

1

soluble

CBU_1129

29541703

nifS

cysteine desulfurase [Coxiella burnetii ...

396

Conserved; Drug target functions

Phase 3: June 2008

1P3W

57.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04503
(show subtarget assignments)

1

cloned

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00070
(show subtarget assignments)

0

work_stopped

NT01ST1465

16419700

flgK

hook-filament junction protein 1

553

Virulence

Phase 1: October 2007

2D4Y

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01225
(show subtarget assignments)

1

purified

BA_4139

61211625

Phosphopantetheine adenylyltransferase (...

163

Drug Target Function

Phase 2: March 2008

1O6B

71.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04452
(show subtarget assignments)

1

purified

YPO1049

42560001

RecName: Full=Undecaprenyl pyrophosphate...

252

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

76.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00017
(show subtarget assignments)

1

purified

BA_4333

81581445

ribBA

Riboflavin biosynthesis protein ribBA [I...

397

Drug Target Homolog

Phase 1: October 2007

2BZ0

27%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02356
(show subtarget assignments)

1

cloned

FTT1296

56708355

ubiE

menaquinone biosynthesis methyltransfera...

250

Conserved; Drug target functions

Phase 3: June 2008

2AVN

20%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00313
(show subtarget assignments)

1

expressed

CBU_0647

29653985

ribA

riboflavin biosynthesis protein RibA

406

Drug Target Function

Phase 2: March 2008

2BZ0

27.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04402
(show subtarget assignments)

1

cloned

VC2254

15642252

1-deoxy-D-xylulose 5-phosphate reductois...

402

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K5H

60.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01205
(show subtarget assignments)

1

in_pdb
3OS6

BA_2369

30257005

dhbC

isochorismate synthase DhbC

399

Drug Target Function

Phase 2: March 2008

3OS6

99.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04426
(show subtarget assignments)

1

expressed

GBAA4339

47529636

bioF

8-amino-7-oxononanoate synthase [Bacillu...

395

putative drug target function;

Phase 4: April 2009

3A2B

33.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04048
(show subtarget assignments)

1

purified

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04384
(show subtarget assignments)

1

in_pdb
3PZS

YPO2368

218929459

pdxY

pyridoxamine kinase [Yersinia pestis CO9...

286

conserved gene; putative drug target function;

Phase 4: April 2009

3PZS

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02227
(show subtarget assignments)

1

cloned

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04504
(show subtarget assignments)

1

cloned

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04677
(show subtarget assignments)

1

soluble

GBAA2371

47527666

dhbB

isochorismatase [Bacillus anthracis str....

295

putative drug target function;

Phase 4: April 2009

2FQ1

45.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00308
(show subtarget assignments)

1

soluble

CBU_0288

29653640

coaD

phosphopantetheine adenylyltransferase

159

Drug Target Function

Phase 2: March 2008

3IKZ

47.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02134
(show subtarget assignments)

1

soluble

CBU_0597

29541198

oxygen-independent coproporphyrinogen II...

375

Conserved; Drug target functions

Phase 3: June 2008

1OLT

20.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04342
(show subtarget assignments)

1

cloned

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01753
(show subtarget assignments)

1

expressed

CBU_0423

29541032

panC

pantoate--beta-alanine ligase [Coxiella ...

257

Conserved; Drug target functions

Phase 3: June 2008

3N8H

40.9%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00067
(show subtarget assignments)

1

in_pdb
3PFI

NT01CJ1369

6968796

ruvB

holliday junction DNA helicase [Campylob...

335

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3PFI

100%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01181
(show subtarget assignments)

1

purified

BA_0085

38372318

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

158

Drug Target Function

Phase 2: March 2008

3F6M

64.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02213
(show subtarget assignments)

1

expressed

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04360
(show subtarget assignments)

1

purified

YPO2018

115347740

putative protoporphyrinogen oxidase [Yer...

276

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1T43

62.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02332
(show subtarget assignments)

1

purified

GBAA1462

47526735

UbiE/COQ5 family methlytransferase [Baci...

258

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UJD

22.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02324
(show subtarget assignments)

1

purified

FTT0581

56707709

coaD

phosphopantetheine adenylyltransferase [...

162

Conserved; Drug target functions

Phase 3: June 2008

1VLH

50.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00008
(show subtarget assignments)

1

purified

BA_1445

30255378

cysG

uroporphyrin-III C-methyltransferase

258

Drug Target Homolog

Phase 1: October 2007

1PJQ

43.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01436
(show subtarget assignments)

1

crystallized

VC1976

15641978

menaquinone-specific isochorismate synth...

435

Drug Target Function

Phase 2: March 2008

3GSE

42.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02217
(show subtarget assignments)

1

expressed

FTT1018c

56708107

dxs

1-deoxy-D-xylulose-5-phosphate synthase ...

615

Conserved; Drug target functions

Phase 3: June 2008

2O1S

56.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

OtherPyridoxine,Thiamine

IDP04374
(show subtarget assignments)

1

crystallized

YPO3501

218930515

folP

dihydropteroate synthase [Yersinia pesti...

277

conserved gene; putative drug target function;

Phase 4: April 2009

1AJ0

74.7%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01415
(show subtarget assignments)

1

purified

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02106
(show subtarget assignments)

1

cloned

FTT0654

56707776

elbB

isoprenoid biosynthesis protein [Francis...

219

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OY1

47.5%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04281
(show subtarget assignments)

1

cloned

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04298
(show subtarget assignments)

1

soluble

VCA0827

15601582

phhB

pterin-4-alpha-carbinolamine dehydratase...

109

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1RU0

33%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04322
(show subtarget assignments)

1

cloned

VC1001

15641016

folylpolyglutamate synthase/dihydrofolat...

421

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3N2A

53.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04313
(show subtarget assignments)

1

purified

GBAA2368

47527663

entA

2,3-dihydroxybenzoate-2,3-dehydrogenase ...

258

virulence factor; putative drug target function;

Phase 4: April 2009

2FWM

45.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01142
(show subtarget assignments)

1

expressed

BA_1249

30255198

pabA-2

para-aminobenzoate synthase glutamine am...

195

Drug Target Function

Phase 2: March 2008

1QDL

43.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01882
(show subtarget assignments)

1

soluble

FTT0927

56708027

hemL

glutamate-1-semialdehyde-2,1-aminomutase...

431

Drug Target

Phase 3: June 2008

2GSA

53.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

Targets