Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02019 (show subtarget assignments)	1	cloned	CBU_1182	29541752	iscS	cysteine desulfurase [Coxiella burnetii ...	380	Conserved; Drug target functions	Phase 3: June 2008	1P3W	43.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02503 (show subtarget assignments)	1	cloned	YPO2502	16122723	gutB	putative zinc-binding dehydrogenase [Yer...	408	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	2D8A	30.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Chlorophyll and bacteriochlorphyll

IDP02017 (show subtarget assignments)	1	soluble	FTT0047	56707226	hemE	uroporphyrinogen decarboxylase [Francise...	344	Conserved; Drug target functions	Phase 3: June 2008	3CYV	47.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00128 (show subtarget assignments)	1	soluble	NT01ST3027	16765755	pdxK	mp65f07.r1 Soares_thymus_2NbMT Mus muscu...	288	Essential	Phase 1: October 2007	2DDM	65.6%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02424 (show subtarget assignments)	1	cloned	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02522 (show subtarget assignments)	1	expressed	CBU_1966	29542521	hemA	glutamyl-tRNA reductase [Coxiella burnet...	413	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	30.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04545 (show subtarget assignments)	1	purified	CPF_1198	110801283		glutathione peroxidase [Clostridium perf...	178	drug target; putative drug target function;	Phase 4: April 2009	3CMI	48.3%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP04735 (show subtarget assignments)	1	purified	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02255 (show subtarget assignments)	1	cloned	FTT1130c	56708207	cphA	cyanophycin synthetase [Francisella tula...	940	Drug Target	Phase 3: June 2008	2WTZ	13.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02241 (show subtarget assignments)	1	purified	FTT1129c	56708206		hypothetical protein FTT1129c [Francisel...	561	Drug Target	Phase 3: June 2008	1O5Z	11.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02832 (show subtarget assignments)	1	expressed	FTT1518	56708554	ogt	methylated-DNA--protein-cysteine methylt...	190	Conserved; Drug target functions	Phase 3: June 2008	1SFE	28.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy	Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP05530 (show subtarget assignments)	1	cloned	CD1534	126699138		putative gamma-glutamyltranspeptidase [C...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NLZ	54.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs

IDP91260 (show subtarget assignments)	8	selected	NT02SA2397	14248172	nasF	uroporphyrin-III C-methyl transferase [S...	325	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	28%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91226 (show subtarget assignments)	8	selected	NT04EC4239	26110396	cysG	Siroheme synthase [Escherichia coli CFT0...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	90.2%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91250 (show subtarget assignments)	8	selected	NT01LM1295	16410617	lmo1201	lmo1201 [Listeria monocytogenes]	493	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	24.9%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05747 (show subtarget assignments)	1	cloned	CD3439	126701062	cobT	nicotinate-nucleotide--dimethylbenzimida...	348	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1D0S	43.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05539 (show subtarget assignments)	1	purified	CD3426	126701049	cbiF	precorrin-4 C(11)-methyltransferase [Clo...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3NDC	41.6%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05541 (show subtarget assignments)	1	cloned	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05537 (show subtarget assignments)	1	cloned	CD3419	126701042	hemB	delta-aminolevulinic acid dehydratase [C...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1W5Q	55.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05322 (show subtarget assignments)	1	cloned	CD3430	126701053	cbiC	cobalt-precorrin-8X methylmutase [Clostr...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AFR	41.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05308 (show subtarget assignments)	1	soluble	CD3420	126701043	hemD	porphyrin biosynthesis protein [Clostrid...	499	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PJQ	25.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05271 (show subtarget assignments)	1	cloned	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05218 (show subtarget assignments)	1	cloned	CD3433	126701056	cbiB	cobalamin biosynthesis protein [Clostrid...	323	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05217 (show subtarget assignments)	1	purified	CD3421	126701044	hemC	porphobilinogen deaminase [Clostridium d...	301	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PDA	37.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05210 (show subtarget assignments)	1	cloned	CD2464	126700081	hemN	oxygen-independent coproporphyrinogen II...	380	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1OLT	20.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05062 (show subtarget assignments)	1	purified	CD1919	126699529		putative ethanolamine/propanediol utiliz...	253	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05732 (show subtarget assignments)	1	cloned	CD1205	126698801	ispA	geranyltranstransferase [Clostridium dif...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J1P	45.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP91275 (show subtarget assignments)	8	selected	NT05BA4361	49181104		gcpE protein [Bacillus anthracis str. St...	367	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3NOY	48%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP91280 (show subtarget assignments)	8	selected	NT05BA5064	49181767		conserved hypothetical protein [Bacillus...	430	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VH4	15.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP05659 (show subtarget assignments)	1	cloned	lmo0236	16802282	-	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	157	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GX1	61.8%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP05740 (show subtarget assignments)	1	cloned	CD2372	126699987	nadA	quinolinate synthetase [Clostridium diff...	304	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2QS0	42.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05741 (show subtarget assignments)	1	soluble	CD2371	126699986	nadB	L-aspartate oxidase [Clostridium diffici...	433	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1CHU	37%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05299 (show subtarget assignments)	1	soluble	CD2524	126700141	nadD	nicotinate-nucleotide adenylyltransferas...	229	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KAM	34.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05265 (show subtarget assignments)	1	purified	CD3543	126701167		putative nicotinate phosphribosyltransfe...	476	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2F7F	43.3%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05064 (show subtarget assignments)	1	cloned	CD2370	126699985	nadC	nicotinate-nucleotide pyrophosphorylase ...	270	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1X1O	46.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP91259 (show subtarget assignments)	8	selected	NT02SA1746	14247541	ribA	riboflavin biosynthesis protein [Staphyl...	393	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MGZ	24.2%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05517 (show subtarget assignments)	1	soluble	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91241 (show subtarget assignments)	8	selected	HP0802	2313933		GTP cyclohydrolase II (ribA) [Helicobact...	192	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	47.7%	Helicobacter pylori	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91239 (show subtarget assignments)	8	selected	HP0804	2313934		GTP cyclohydrolase II/3,4-dihydroxy-2-bu...	344	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1TKS	28.2%	Helicobacter pylori	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91231 (show subtarget assignments)	8	selected	NT04EC1793	26108012	ribA	GTP cyclohydrolase II [Escherichia coli ...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	99.5%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05514 (show subtarget assignments)	1	purified	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05516 (show subtarget assignments)	1	soluble	CD1697	126699303	ribH	riboflavin synthase beta chain (6,7-dime...	158	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RVV	66.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05202 (show subtarget assignments)	1	cloned	CD1700	126699306	ribD	riboflavin biosynthesis protein [Clostri...	367	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HXV	41.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05201 (show subtarget assignments)	1	cloned	CD1698	126699304	ribA	riboflavin biosynthesis protein [Clostri...	408	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MGZ	25.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05736 (show subtarget assignments)	1	soluble	CD1702A	126699309	thiS	putative thiamine biosynthesis protein [...	64	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1TYG	41.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05735 (show subtarget assignments)	1	soluble	CD1599	126699203	thiD	putative phosphomethylpyrimidine kinase ...	264	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1UB0	44.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05512 (show subtarget assignments)	1	cloned	CD1601	126699205	thiE1	thiamine-phosphate pyrophosphorylase [Cl...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XI3	41%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05519 (show subtarget assignments)	1	cloned	CD1704	126699311	thiG	thiazole synthase [Clostridium difficile...	261	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XM3	47.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05518 (show subtarget assignments)	1	cloned	CD1702	126699308	thiC	thiamine biosynthesis protein ThiC [Clos...	438	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3EPM	43.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05292 (show subtarget assignments)	1	cloned	CD1600	126699204	thiK	hydroxyethylthiazole kinase [Clostridium...	262	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3HPD	35.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05211 (show subtarget assignments)	1	cloned	CD2574	126700193		putative thiamine pyrophosphokinase [Clo...	213	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3IHK	28.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00589 (show subtarget assignments)	1	soluble	YPO0954	161486886	mltC	membrane-bound lytic murein transglycosy...	358	Drug Target Function	Phase 2: March 2008	2Y8P	19.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01881 (show subtarget assignments)	1	cloned	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01124 (show subtarget assignments)	1	soluble	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00583 (show subtarget assignments)	1	cloned	YPO2752	16122956	mepA	penicillin-insensitive murein endopeptid...	275	Drug Target Function	Phase 2: March 2008	1TZP	67.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01952 (show subtarget assignments)	1	cloned	Cj1432c	15792750		putative sugar transferase [Campylobacte...	1031	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2IV7	7.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01116 (show subtarget assignments)	1	expressed	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01110 (show subtarget assignments)	1	in_pdb 3RYK	BA_1229	30255178	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase	181	Conserved Gene / Pathway	Phase 2: March 2008	3RYK	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02244 (show subtarget assignments)	1	cloned	GBAA1818	47777969		N-acetylmuramoyl-L-alanine amidase [Baci...	459	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	12.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01103 (show subtarget assignments)	1	cloned	BA_1387	47605671		D-alanine--poly(phosphoribitol) ligase s...	79	Drug Target Function	Phase 2: March 2008	1DV5	45.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00575 (show subtarget assignments)	1	in_pdb 3V4Z	YPO0557	16120885	ddl	D-alanine--D-alanine ligase	306	Drug Target Function	Phase 2: March 2008	3V4Z	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02376 (show subtarget assignments)	1	cloned	FTT0451	56707593	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	416	Conserved; Drug target functions	Phase 3: June 2008	1E0D	31.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00124 (show subtarget assignments)	0	work_stopped	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01840 (show subtarget assignments)	1	soluble	STM2861	16766167	sitA	putative periplasmic binding protein [Sa...	305	Conserved; Drug target functions	Phase 3: June 2008	1XVL	53.4%	Salmonella enterica	Cell envelope	Other

IDP02378 (show subtarget assignments)	1	cloned	CBU_1675	29542234	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	280	Conserved; Drug target functions	Phase 3: June 2008	3T4C	62.5%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00123 (show subtarget assignments)	1	expressed	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01078 (show subtarget assignments)	1	soluble	STM4137	16767396	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	342	Essential Gene	Phase 2: March 2008	1MBB	82.2%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04151 (show subtarget assignments)	1	cloned	YPO3864	218930867	nfrC	UDP-N-acetylglucosamine 2-epimerase [Yer...	376	drug target; putative drug target function;	Phase 4: April 2009	1F6D	78.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00015 (show subtarget assignments)	1	purified	BA_4048	47605856		UDP-N-acetylenolpyruvoylglucosamine redu...	301	Drug Target Homolog	Phase 1: October 2007	1HSK	39.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01836 (show subtarget assignments)	1	cloned	Cj1659	15792963	p19	hypothetical protein Cj1659 [Campylobact...	179	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3LZL	88.3%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01068 (show subtarget assignments)	0	work_stopped	STM3920	16767195	wecB	UDP-N-acetyl glucosamine-2-epimerase	376	Drug Target Function	Phase 2: March 2008	1F6D	85.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00121 (show subtarget assignments)	1	in_pdb 3DQQ	NT01ST3629	16766223	ygbK	putative tRNA synthase	420	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DQQ	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00120 (show subtarget assignments)	1	expressed	NT01ST0780	16764019	ybeB	hypothetical protein STM0642	105	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2ID1	38.1%	Salmonella enterica	Cell envelope	Other

IDP01065 (show subtarget assignments)	1	expressed	STM3722	16767007	rfaG	glucosyltransferase I	374	Drug Target Function	Phase 2: March 2008	2IV7	86.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01064 (show subtarget assignments)	1	cloned	STM3719	16767004	rfaB	UDP-D-galactose:(glucosyl)lipopolysaccha...	359	Essential Gene	Phase 2: March 2008	2JJM	13.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02010 (show subtarget assignments)	1	soluble	lmo1829	16803869		hypothetical protein lmo1829 [Listeria m...	570	Known virulence-adherence; PMID:15228540	Phase 3: June 2008	3DOA	21.1%	Listeria monocytogenes	Cell envelope	Surface structures

IDP01487 (show subtarget assignments)	1	soluble	VCA0270	15601038		D-alanyl-D-alanine carboxypeptidase	389	Drug Target Function	Phase 2: March 2008	1NZO	44.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00558 (show subtarget assignments)	1	purified	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02373 (show subtarget assignments)	1	expressed	FTT0438	56707582	mpl	UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	456	Conserved; Drug target functions	Phase 3: June 2008	3HN7	41.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04487 (show subtarget assignments)	1	expressed	YPO3598	115349219		putative membrane protein [Yersinia pest...	255	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP02471 (show subtarget assignments)	1	cloned	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP04480 (show subtarget assignments)	1	selected	YPO3104	218930142	wbyK	putative mannosyltransferase [Yersinia p...	337	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	2BIS	25.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00548 (show subtarget assignments)	1	cloned	YPO0549	16120877	ftsI	penicillin-binding protein 3	587	Drug Target Function	Phase 2: March 2008	3OC2	41.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04091 (show subtarget assignments)	1	cloned	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP00117 (show subtarget assignments)	1	purified	NT01ST0298	16763632	yaeB	putative regulatory protein	235	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1XQB	47.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04088 (show subtarget assignments)	1	soluble	CPF_2931	110800177		putative lipoprotein [Clostridium perfri...	184	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01030 (show subtarget assignments)	1	cloned	STM2107	16765437	wcaH	GDP-mannose mannosyl hydrolase	167	Conserved Gene / Pathway	Phase 2: March 2008	2I8T	65.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00542 (show subtarget assignments)	1	cloned	YPO2744	16122948	fadL	long-chain fatty acid outer membrane tra...	423	Virulence Associated Factor	Phase 2: March 2008	1T16	64%	Yersinia pestis	Cell envelope	Other

IDP02225 (show subtarget assignments)	1	cloned	CBU_1338	29541903		D-alanine--D-alanine ligase [Coxiella bu...	372	Conserved; Drug target functions	Phase 3: June 2008	3TQT	100%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01024 (show subtarget assignments)	1	purified	STM1172	16764528	flgM	anti-sigma28 factor FlgM	97	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Cell envelope	Surface structures

IDP02468 (show subtarget assignments)	1	cloned	Cj0914c	15792243		invasion antigen B [Campylobacter jejuni...	610	Known Predicted virulence-invasion; PMID:10339609	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP01019 (show subtarget assignments)	0	work_stopped	STM0228	16763618	lpxA	UDP-N-acetylglucosamine acyltransferase ...	262	Essential Gene	Phase 2: March 2008	1LXA	93.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02223 (show subtarget assignments)	1	expressed	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01822 (show subtarget assignments)	1	cloned	FTT0317	56707470	uppS	undecaprenyl pyrophosphate synthetase [F...	257	Conserved; Drug target functions	Phase 3: June 2008	1JP3	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04063 (show subtarget assignments)	1	cloned	CPF_0514	110800714		putative lipoprotein [Clostridium perfri...	176	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01827 (show subtarget assignments)	1	expressed	Cj0526c	15791887	fliE	flagellar hook-basal body protein FliE [...	98	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP00114 (show subtarget assignments)	1	purified	GVCV52ORF0478	9654887		Vibrio cholerae O1 biovar eltor str. N16...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3JVU	65.8%	Vibrio cholerae	Cell envelope	Surface structures

IDP04460 (show subtarget assignments)	1	expressed	YPO1482	115347233		putative membrane protein [Yersinia pest...	1140	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP00535 (show subtarget assignments)	1	soluble	YPO3506	16123652	dacB	D-alanyl-D-alanine carboxypeptidase/endo...	482	Drug Target Function	Phase 2: March 2008	2EX2	77.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02469 (show subtarget assignments)	1	cloned	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02019
(show subtarget assignments)

1

cloned

CBU_1182

29541752

iscS

cysteine desulfurase [Coxiella burnetii ...

380

Conserved; Drug target functions

Phase 3: June 2008

1P3W

43.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02503
(show subtarget assignments)

1

cloned

YPO2502

16122723

gutB

putative zinc-binding dehydrogenase [Yer...

408

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

2D8A

30.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Chlorophyll and bacteriochlorphyll

IDP02017
(show subtarget assignments)

1

soluble

FTT0047

56707226

hemE

uroporphyrinogen decarboxylase [Francise...

344

Conserved; Drug target functions

Phase 3: June 2008

3CYV

47.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00128
(show subtarget assignments)

1

soluble

NT01ST3027

16765755

pdxK

mp65f07.r1 Soares_thymus_2NbMT Mus muscu...

288

Essential

Phase 1: October 2007

2DDM

65.6%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02424
(show subtarget assignments)

1

cloned

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02522
(show subtarget assignments)

1

expressed

CBU_1966

29542521

hemA

glutamyl-tRNA reductase [Coxiella burnet...

413

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

30.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04545
(show subtarget assignments)

1

purified

CPF_1198

110801283

glutathione peroxidase [Clostridium perf...

178

drug target; putative drug target function;

Phase 4: April 2009

3CMI

48.3%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP04735
(show subtarget assignments)

1

purified

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02255
(show subtarget assignments)

1

cloned

FTT1130c

56708207

cphA

cyanophycin synthetase [Francisella tula...

940

Drug Target

Phase 3: June 2008

2WTZ

13.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02241
(show subtarget assignments)

1

purified

FTT1129c

56708206

hypothetical protein FTT1129c [Francisel...

561

Drug Target

Phase 3: June 2008

1O5Z

11.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02832
(show subtarget assignments)

1

expressed

FTT1518

56708554

ogt

methylated-DNA--protein-cysteine methylt...

190

Conserved; Drug target functions

Phase 3: June 2008

1SFE

28.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy

Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP05530
(show subtarget assignments)

1

cloned

CD1534

126699138

putative gamma-glutamyltranspeptidase [C...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NLZ

54.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs

IDP91260
(show subtarget assignments)

8

selected

NT02SA2397

14248172

nasF

uroporphyrin-III C-methyl transferase [S...

325

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

28%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91226
(show subtarget assignments)

8

selected

NT04EC4239

26110396

cysG

Siroheme synthase [Escherichia coli CFT0...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

90.2%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91250
(show subtarget assignments)

8

selected

NT01LM1295

16410617

lmo1201

lmo1201 [Listeria monocytogenes]

493

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

24.9%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05747
(show subtarget assignments)

1

cloned

CD3439

126701062

cobT

nicotinate-nucleotide--dimethylbenzimida...

348

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1D0S

43.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05539
(show subtarget assignments)

1

purified

CD3426

126701049

cbiF

precorrin-4 C(11)-methyltransferase [Clo...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3NDC

41.6%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05541
(show subtarget assignments)

1

cloned

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05537
(show subtarget assignments)

1

cloned

CD3419

126701042

hemB

delta-aminolevulinic acid dehydratase [C...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1W5Q

55.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05322
(show subtarget assignments)

1

cloned

CD3430

126701053

cbiC

cobalt-precorrin-8X methylmutase [Clostr...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AFR

41.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05308
(show subtarget assignments)

1

soluble

CD3420

126701043

hemD

porphyrin biosynthesis protein [Clostrid...

499

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PJQ

25.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05271
(show subtarget assignments)

1

cloned

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05218
(show subtarget assignments)

1

cloned

CD3433

126701056

cbiB

cobalamin biosynthesis protein [Clostrid...

323

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05217
(show subtarget assignments)

1

purified

CD3421

126701044

hemC

porphobilinogen deaminase [Clostridium d...

301

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PDA

37.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05210
(show subtarget assignments)

1

cloned

CD2464

126700081

hemN

oxygen-independent coproporphyrinogen II...

380

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1OLT

20.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05062
(show subtarget assignments)

1

purified

CD1919

126699529

putative ethanolamine/propanediol utiliz...

253

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05732
(show subtarget assignments)

1

cloned

CD1205

126698801

ispA

geranyltranstransferase [Clostridium dif...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J1P

45.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone

IDP91275
(show subtarget assignments)

8

selected

NT05BA4361

49181104

gcpE protein [Bacillus anthracis str. St...

367

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3NOY

48%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP91280
(show subtarget assignments)

8

selected

NT05BA5064

49181767

conserved hypothetical protein [Bacillus...

430

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VH4

15.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP05659
(show subtarget assignments)

1

cloned

lmo0236

16802282

-

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

157

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GX1

61.8%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Other

IDP05740
(show subtarget assignments)

1

cloned

CD2372

126699987

nadA

quinolinate synthetase [Clostridium diff...

304

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2QS0

42.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05741
(show subtarget assignments)

1

soluble

CD2371

126699986

nadB

L-aspartate oxidase [Clostridium diffici...

433

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1CHU

37%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05299
(show subtarget assignments)

1

soluble

CD2524

126700141

nadD

nicotinate-nucleotide adenylyltransferas...

229

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KAM

34.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05265
(show subtarget assignments)

1

purified

CD3543

126701167

putative nicotinate phosphribosyltransfe...

476

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2F7F

43.3%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05064
(show subtarget assignments)

1

cloned

CD2370

126699985

nadC

nicotinate-nucleotide pyrophosphorylase ...

270

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1X1O

46.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP91259
(show subtarget assignments)

8

selected

NT02SA1746

14247541

ribA

riboflavin biosynthesis protein [Staphyl...

393

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MGZ

24.2%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05517
(show subtarget assignments)

1

soluble

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91241
(show subtarget assignments)

8

selected

HP0802

2313933

GTP cyclohydrolase II (ribA) [Helicobact...

192

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

47.7%

Helicobacter pylori

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91239
(show subtarget assignments)

8

selected

HP0804

2313934

GTP cyclohydrolase II/3,4-dihydroxy-2-bu...

344

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1TKS

28.2%

Helicobacter pylori

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91231
(show subtarget assignments)

8

selected

NT04EC1793

26108012

ribA

GTP cyclohydrolase II [Escherichia coli ...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

99.5%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05514
(show subtarget assignments)

1

purified

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05516
(show subtarget assignments)

1

soluble

CD1697

126699303

ribH

riboflavin synthase beta chain (6,7-dime...

158

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RVV

66.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05202
(show subtarget assignments)

1

cloned

CD1700

126699306

ribD

riboflavin biosynthesis protein [Clostri...

367

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HXV

41.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05201
(show subtarget assignments)

1

cloned

CD1698

126699304

ribA

riboflavin biosynthesis protein [Clostri...

408

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MGZ

25.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05736
(show subtarget assignments)

1

soluble

CD1702A

126699309

thiS

putative thiamine biosynthesis protein [...

64

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1TYG

41.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05735
(show subtarget assignments)

1

soluble

CD1599

126699203

thiD

putative phosphomethylpyrimidine kinase ...

264

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1UB0

44.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05512
(show subtarget assignments)

1

cloned

CD1601

126699205

thiE1

thiamine-phosphate pyrophosphorylase [Cl...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XI3

41%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05519
(show subtarget assignments)

1

cloned

CD1704

126699311

thiG

thiazole synthase [Clostridium difficile...

261

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XM3

47.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05518
(show subtarget assignments)

1

cloned

CD1702

126699308

thiC

thiamine biosynthesis protein ThiC [Clos...

438

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3EPM

43.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05292
(show subtarget assignments)

1

cloned

CD1600

126699204

thiK

hydroxyethylthiazole kinase [Clostridium...

262

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3HPD

35.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05211
(show subtarget assignments)

1

cloned

CD2574

126700193

putative thiamine pyrophosphokinase [Clo...

213

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3IHK

28.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00589
(show subtarget assignments)

1

soluble

YPO0954

161486886

mltC

membrane-bound lytic murein transglycosy...

358

Drug Target Function

Phase 2: March 2008

2Y8P

19.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01881
(show subtarget assignments)

1

cloned

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01124
(show subtarget assignments)

1

soluble

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00583
(show subtarget assignments)

1

cloned

YPO2752

16122956

mepA

penicillin-insensitive murein endopeptid...

275

Drug Target Function

Phase 2: March 2008

1TZP

67.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01952
(show subtarget assignments)

1

cloned

Cj1432c

15792750

putative sugar transferase [Campylobacte...

1031

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2IV7

7.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01116
(show subtarget assignments)

1

expressed

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01110
(show subtarget assignments)

1

in_pdb
3RYK

BA_1229

30255178

rfbC

dTDP-4-dehydrorhamnose 3,5-epimerase

181

Conserved Gene / Pathway

Phase 2: March 2008

3RYK

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02244
(show subtarget assignments)

1

cloned

GBAA1818

47777969

N-acetylmuramoyl-L-alanine amidase [Baci...

459

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

12.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01103
(show subtarget assignments)

1

cloned

BA_1387

47605671

D-alanine--poly(phosphoribitol) ligase s...

79

Drug Target Function

Phase 2: March 2008

1DV5

45.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00575
(show subtarget assignments)

1

in_pdb
3V4Z

YPO0557

16120885

ddl

D-alanine--D-alanine ligase

306

Drug Target Function

Phase 2: March 2008

3V4Z

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02376
(show subtarget assignments)

1

cloned

FTT0451

56707593

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

416

Conserved; Drug target functions

Phase 3: June 2008

1E0D

31.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00124
(show subtarget assignments)

0

work_stopped

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01840
(show subtarget assignments)

1

soluble

STM2861

16766167

sitA

putative periplasmic binding protein [Sa...

305

Conserved; Drug target functions

Phase 3: June 2008

1XVL

53.4%

Salmonella enterica

Cell envelope

Other

IDP02378
(show subtarget assignments)

1

cloned

CBU_1675

29542234

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

280

Conserved; Drug target functions

Phase 3: June 2008

3T4C

62.5%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00123
(show subtarget assignments)

1

expressed

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01078
(show subtarget assignments)

1

soluble

STM4137

16767396

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

342

Essential Gene

Phase 2: March 2008

1MBB

82.2%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04151
(show subtarget assignments)

1

cloned

YPO3864

218930867

nfrC

UDP-N-acetylglucosamine 2-epimerase [Yer...

376

drug target; putative drug target function;

Phase 4: April 2009

1F6D

78.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00015
(show subtarget assignments)

1

purified

BA_4048

47605856

UDP-N-acetylenolpyruvoylglucosamine redu...

301

Drug Target Homolog

Phase 1: October 2007

1HSK

39.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01836
(show subtarget assignments)

1

cloned

Cj1659

15792963

p19

hypothetical protein Cj1659 [Campylobact...

179

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3LZL

88.3%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01068
(show subtarget assignments)

0

work_stopped

STM3920

16767195

wecB

UDP-N-acetyl glucosamine-2-epimerase

376

Drug Target Function

Phase 2: March 2008

1F6D

85.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00121
(show subtarget assignments)

1

in_pdb
3DQQ

NT01ST3629

16766223

ygbK

putative tRNA synthase

420

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DQQ

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00120
(show subtarget assignments)

1

expressed

NT01ST0780

16764019

ybeB

hypothetical protein STM0642

105

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2ID1

38.1%

Salmonella enterica

Cell envelope

Other

IDP01065
(show subtarget assignments)

1

expressed

STM3722

16767007

rfaG

glucosyltransferase I

374

Drug Target Function

Phase 2: March 2008

2IV7

86.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01064
(show subtarget assignments)

1

cloned

STM3719

16767004

rfaB

UDP-D-galactose:(glucosyl)lipopolysaccha...

359

Essential Gene

Phase 2: March 2008

2JJM

13.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02010
(show subtarget assignments)

1

soluble

lmo1829

16803869

hypothetical protein lmo1829 [Listeria m...

570

Known virulence-adherence; PMID:15228540

Phase 3: June 2008

3DOA

21.1%

Listeria monocytogenes

Cell envelope

Surface structures

IDP01487
(show subtarget assignments)

1

soluble

VCA0270

15601038

D-alanyl-D-alanine carboxypeptidase

389

Drug Target Function

Phase 2: March 2008

1NZO

44.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00558
(show subtarget assignments)

1

purified

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02373
(show subtarget assignments)

1

expressed

FTT0438

56707582

mpl

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

456

Conserved; Drug target functions

Phase 3: June 2008

3HN7

41.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04487
(show subtarget assignments)

1

expressed

YPO3598

115349219

putative membrane protein [Yersinia pest...

255

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP02471
(show subtarget assignments)

1

cloned

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP04480
(show subtarget assignments)

1

selected

YPO3104

218930142

wbyK

putative mannosyltransferase [Yersinia p...

337

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

2BIS

25.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00548
(show subtarget assignments)

1

cloned

YPO0549

16120877

ftsI

penicillin-binding protein 3

587

Drug Target Function

Phase 2: March 2008

3OC2

41.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04091
(show subtarget assignments)

1

cloned

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP00117
(show subtarget assignments)

1

purified

NT01ST0298

16763632

yaeB

putative regulatory protein

235

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1XQB

47.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04088
(show subtarget assignments)

1

soluble

CPF_2931

110800177

putative lipoprotein [Clostridium perfri...

184

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01030
(show subtarget assignments)

1

cloned

STM2107

16765437

wcaH

GDP-mannose mannosyl hydrolase

167

Conserved Gene / Pathway

Phase 2: March 2008

2I8T

65.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00542
(show subtarget assignments)

1

cloned

YPO2744

16122948

fadL

long-chain fatty acid outer membrane tra...

423

Virulence Associated Factor

Phase 2: March 2008

1T16

64%

Yersinia pestis

Cell envelope

Other

IDP02225
(show subtarget assignments)

1

cloned

CBU_1338

29541903

D-alanine--D-alanine ligase [Coxiella bu...

372

Conserved; Drug target functions

Phase 3: June 2008

3TQT

100%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01024
(show subtarget assignments)

1

purified

STM1172

16764528

flgM

anti-sigma28 factor FlgM

97

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Cell envelope

Surface structures

IDP02468
(show subtarget assignments)

1

cloned

Cj0914c

15792243

invasion antigen B [Campylobacter jejuni...

610

Known Predicted virulence-invasion; PMID:10339609

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP01019
(show subtarget assignments)

0

work_stopped

STM0228

16763618

lpxA

UDP-N-acetylglucosamine acyltransferase ...

262

Essential Gene

Phase 2: March 2008

1LXA

93.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02223
(show subtarget assignments)

1

expressed

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01822
(show subtarget assignments)

1

cloned

FTT0317

56707470

uppS

undecaprenyl pyrophosphate synthetase [F...

257

Conserved; Drug target functions

Phase 3: June 2008

1JP3

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04063
(show subtarget assignments)

1

cloned

CPF_0514

110800714

putative lipoprotein [Clostridium perfri...

176

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01827
(show subtarget assignments)

1

expressed

Cj0526c

15791887

fliE

flagellar hook-basal body protein FliE [...

98

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP00114
(show subtarget assignments)

1

purified

GVCV52ORF0478

9654887

Vibrio cholerae O1 biovar eltor str. N16...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3JVU

65.8%

Vibrio cholerae

Cell envelope

Surface structures

IDP04460
(show subtarget assignments)

1

expressed

YPO1482

115347233

putative membrane protein [Yersinia pest...

1140

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP00535
(show subtarget assignments)

1

soluble

YPO3506

16123652

dacB

D-alanyl-D-alanine carboxypeptidase/endo...

482

Drug Target Function

Phase 2: March 2008

2EX2

77.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02469
(show subtarget assignments)

1

cloned

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan