Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00764 (show subtarget assignments)	1	expressed	SACOL0447	57286820		phosphoglycerate mutase family protein	193	Drug Target Function	Phase 2: March 2008	1C7Z	31.1%	Staphylococcus aureus	Unknown function	General

IDP91356 (show subtarget assignments)	8	cloned	VV1_2923	27366200		DNA-binding protein H-NS [Vibrio vulnifi...	135	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1OV9	31.1%	Vibrio vulnificus

IDP02618 (show subtarget assignments)	1	cloned	STM2205	16765535	fruK	1-phosphofructokinase [Salmonella typhim...	312	Conserved; Drug target functions	Phase 3: June 2008	3CQD	31.1%	Salmonella enterica	Energy metabolism	Glycolysis/gluconeogenesis

IDP91074 (show subtarget assignments)	8	cloned	MSMEG_5659	118469658		ABC transporter, ATP-binding protein [My...	610	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	31.1%	Mycobacterium smegmatis

IDP01752 (show subtarget assignments)	1	selected	GBAA5282	47778383	nprB	neutral protease B [Bacillus anthracis s...	547	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1KEI	31.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05542 (show subtarget assignments)	1	cloned	Cj0508	6967973	pbpA	hypothetical protein Cj0504c [Campylobac...	643	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FWL	31.1%	Campylobacter jejuni	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00069 (show subtarget assignments)	1	purified	NTL01ST0342	16418853	STM0352	putative cation efflux pump	408	Virulence	Phase 1: October 2007	1T5E	31.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP05713 (show subtarget assignments)	1	cloned	BA_0189	30253696		oligopeptide ABC transporter, oligopepti...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP91402 (show subtarget assignments)	8	soluble	VV1_1001	27364435		ABC-type amino acid transport, signal tr...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GGG	31.2%	Vibrio vulnificus

IDP05742 (show subtarget assignments)	1	cloned	CD2655	126700269	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	457	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1GG4	31.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00053 (show subtarget assignments)	1	soluble	BA_3536	30258071		phenazine biosynthesis protein, PhzF fam...	285	Virulence	Phase 1: October 2007	1QY9	31.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00500 (show subtarget assignments)	1	purified	YPO1784	16122038		putative copper resistance protein	128	Conserved Gene / Pathway	Phase 2: March 2008	1IX2	31.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP02739 (show subtarget assignments)	1	soluble	FTT1321	56708378		peptidase M16 family protein [Francisell...	417	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AMI	31.2%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01870 (show subtarget assignments)	1	cloned	GBAA5710	47531047		serine protease [Bacillus anthracis str....	391	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GCN	31.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91923 (show subtarget assignments)	8	selected	SpneCM_010100002081	298254388		hypothetical protein SpneCM_02081 [Strep...	170	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1S3R	31.2%	Streptococcus pneumoniae

IDP02040 (show subtarget assignments)	1	expressed	GBAA4637	47529935	relA	GTP pyrophosphokinase [Bacillus anthraci...	727	CONSERVED. Additional information: It is responsible for a down-regulation of RN...	Phase 3: June 2008	1VJ7	31.2%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions	N/A

IDP00837 (show subtarget assignments)	1	soluble	SACOL2735	57285289		chromosome partioning protein, ParB fami...	279	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	31.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP01404 (show subtarget assignments)	1	soluble	VC0856	15640872		dnaJ protein	381	Conserved Gene / Pathway	Phase 2: March 2008	3LZ8	31.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP02391 (show subtarget assignments)	1	cloned	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP04546 (show subtarget assignments)	1	cloned	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP02117 (show subtarget assignments)	1	purified	STM4356	16767602	yjeF	hypothetical protein STM4356 [Salmonella...	515	Conserved; Drug target functions	Phase 3: June 2008	2AX3	31.3%	Salmonella enterica	Unknown function	General

IDP00405 (show subtarget assignments)	1	soluble	YPO4025	16124148		putative iron ABC transporter, ATP-bindi...	252	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.3%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP02497 (show subtarget assignments)	1	cloned	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	1FCJ	31.3%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP05730 (show subtarget assignments)	1	soluble	CD0675	126698254		putative acetyltransferase [Clostridium ...	166	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2GE3	31.3%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP01779 (show subtarget assignments)	1	soluble	CBU_0366	29540977	phoR	sensor histidine kinase PhoR protein, pu...	252	Conserved; Drug target functions	Phase 3: June 2008	2C2A	31.3%	Coxiella burnetii	Signal transduction	Two-component systems

IDP05387 (show subtarget assignments)	1	soluble	BA_2041	30256692		putative oligopeptide ABC transporter, o...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP00850 (show subtarget assignments)	1	soluble	SACOL2389	57285120		transcriptional regulatory protein DegU,...	217	Conserved Gene / Pathway	Phase 2: March 2008	1A04	31.3%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP01164 (show subtarget assignments)	1	soluble	BA_5600	30260056		ABC transporter, ATP-binding protein	300	Conserved Gene / Pathway	Phase 2: March 2008	2YYZ	31.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00967 (show subtarget assignments)	1	purified	STM1559	16764903		putative glycosyl hydrolase	842	Essential Gene	Phase 2: March 2008	3HJE	31.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91075 (show subtarget assignments)	8	cloned	jhp0343	15611411	msbA	multi-drug resistance protein [Helicobac...	551	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	31.4%	Helicobacter pylori

IDP90147 (show subtarget assignments)	8	cloned	MPXV_ZAI1979_005_194	68449266		kelch-like protein [Monkeypox virus]	70	similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R	Community Requests	2Q81	31.4%	Monkeypox virus

IDP00954 (show subtarget assignments)	1	purified	STM1189	16764544	maf	Maf-like protein	194	Essential Gene	Phase 2: March 2008	1EX2	31.4%	Salmonella enterica	Cellular processes	Cell division

IDP91272 (show subtarget assignments)	8	selected	NT05BA3926	49180681		RNA polymerase sigma-29 factor [Bacillus...	239	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L0O	31.4%	Bacillus anthracis

IDP02566 (show subtarget assignments)	1	purified	GBAA3033	50196939	adP-2	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	31.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00170 (show subtarget assignments)	1	soluble	VCA0865	15601620	hap	hemagglutinin/protease	609	Virulence	Phase 1: October 2007	1EZM	31.4%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP90509 (show subtarget assignments)	8	purified	Cj0347	15791715	trpF	N-(5'phosphoribosyl)anthranilate isomera...	199	Predicted Essential	Community Requests	1DL3	31.4%	Campylobacter jejuni

IDP01781 (show subtarget assignments)	1	expressed	Cj1616	15792921	chuC	hemin ABC transporter, ATP-binding prote...	258	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	31.4%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01351 (show subtarget assignments)	1	cloned	VCA0387	15601150		toxin resistance protein	169	Conserved Gene / Pathway	Phase 2: March 2008	1YVO	31.4%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP00333 (show subtarget assignments)	1	crystallized	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91540 (show subtarget assignments)	8	selected	FTN_0549	118423054	sspA	stringent starvation protein A [Francise...	210	virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.	Community Requests	3LYK	31.4%	Francisella novicida

IDP02606 (show subtarget assignments)	1	purified	lmo0006	16802054	gyrB	DNA gyrase subunit B [Listeria monocytog...	646	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	1EI1	31.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP91217 (show subtarget assignments)	1	expressed	FTT_0458	56707600	sspA	stringent starvation protein A, regulato...	210	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LYK	31.4%	Francisella tularensis

IDP01929 (show subtarget assignments)	1	cloned	lmo1076	16803116		hypothetical protein lmo1076 [Listeria m...	572	Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888	Phase 3: June 2008	3FI7	31.5%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91644 (show subtarget assignments)	8	purified	NP_215861	15608485		long-chain-fatty-acid--[acyl-carrier-pro...	521	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	3PBK	31.5%	Mycobacterium tuberculosis

IDP01853 (show subtarget assignments)	1	cloned	CBU_1669	29542228	rpoS	RNA polymerase sigma factor RpoS [Coxiel...	352	Conserved; Drug target functions	Phase 3: June 2008	3IYD	31.5%	Coxiella burnetii	Transcription	Transcription factors

IDP91969 (show subtarget assignments)	8	selected	SpneCM_010100009453	298255801		peptidyl-prolyl cis-trans isomerase, cyc...	267	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2A2N	31.5%	Streptococcus pneumoniae

IDP90688 (show subtarget assignments)	8	purified	Cj1595	15792900	rpoA	DNA-directed RNA polymerase subunit alph...	337	Predicted Essential	Community Requests	3IYD	31.5%	Campylobacter jejuni

IDP01356 (show subtarget assignments)	1	soluble	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01060 (show subtarget assignments)	1	crystallized	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01006 (show subtarget assignments)	1	soluble	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP05255 (show subtarget assignments)	1	purified	SACOL0663	57650073	argS	arginyl-tRNA synthetase [Staphylococcus ...	553	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP00215 (show subtarget assignments)	1	cloned	YPO2295	16122519	-	haloacid dehalogenase-like hydrolase fam...	224	Virulence	Phase 1: October 2007	3ED5	31.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP91080 (show subtarget assignments)	8	cloned	Cj0803	6968244	msbA	lipid export ABC transport protein	580	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	31.6%	Campylobacter jejuni

IDP05228 (show subtarget assignments)	1	soluble	lmo0971	16803011	dltD	DltD protein for D-alanine esterificatio...	380	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BMA	31.6%	Listeria monocytogenes	Cell envelope: Other

IDP01654 (show subtarget assignments)	1	expressed	STM1259	16764611		putative ABC-type transport system ATPas...	196	Conserved; Drug target functions	Phase 3: June 2008	1Z47	31.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP90167 (show subtarget assignments)	8	purified	CD1838	123066836		Shikimate kinase	177	Potential drug target. Shikimate pathway enzyme	Community Requests	2PT5	31.6%	Clostridium difficile

IDP02719 (show subtarget assignments)	1	cloned	lmo0262	16802308	inlG	internalin G [Listeria monocytogenes EGD...	490	Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815	Phase 3: June 2008	1M9S	31.6%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP02452 (show subtarget assignments)	1	purified	GBAA3312	47528597		diaminobutyrate--2-oxoglutarate aminotra...	424	Conserved; Essential; Drug target functions	Phase 3: June 2008	2EH6	31.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP00709 (show subtarget assignments)	1	soluble	SACOL0798	57285759		iron compound ABC transporter, ATP-bindi...	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	31.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP90946 (show subtarget assignments)	8	cloned	BP1878	33592926	bvgA	virulence factors transcription regulato...	209	BvgA is the transcriptional activator for all known virulence genes in the human...	Community Requests	3C3W	31.6%	Bordetella pertussis

IDP01245 (show subtarget assignments)	1	cloned	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222 (show subtarget assignments)	1	purified	BA_4049	33301352		UDP-N-acetylglucosamine--N-acetylmuramyl...	364	Drug Target Function	Phase 2: March 2008	1F0K	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00634 (show subtarget assignments)	1	purified	SACOL1722	57284733	tig	trigger factor	433	Drug Target Function	Phase 2: March 2008	1W26	31.6%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP05766 (show subtarget assignments)	1	expressed	S0723	30040469		putative helicase [Shigella flexneri 2a ...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2R6A	31.7%	Shigella flexneri	DNA metabolism: DNA replication, recombination, and repair

IDP90529 (show subtarget assignments)	8	soluble	YPO1127	16121427	nicA	quinolinate synthetase	353	Predicted Essential	Community Requests	2QS0	31.7%	Yersinia pestis

IDP02469 (show subtarget assignments)	1	cloned	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00732 (show subtarget assignments)	1	purified	SACOL2473	57286467		peptide ABC transporter, ATP-binding pro...	271	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	31.7%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00724 (show subtarget assignments)	1	purified	SACOL1822	57286255	arsR	arsenical resistance operon repressor	104	Conserved Gene / Pathway	Phase 2: March 2008	1R1T	31.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00155 (show subtarget assignments)	1	purified	VC0405	15640432	mshE	MSHA biogenesis protein MshE	575	Virulence	Phase 1: October 2007	1P9R	31.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00518 (show subtarget assignments)	1	cloned	YPO1566	16121836		putative hydrolase	280	Virulence Associated Factor	Phase 2: March 2008	3QDF	31.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP02376 (show subtarget assignments)	1	cloned	FTT0451	56707593	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	416	Conserved; Drug target functions	Phase 3: June 2008	1E0D	31.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05453 (show subtarget assignments)	1	purified	BAS5213	49188199	-	arginyl-tRNA synthetase [Bacillus anthra...	556	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.8%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP04136 (show subtarget assignments)	1	purified	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP00721 (show subtarget assignments)	1	expressed	SACOL1613	57286135		ABC transporter, ATP-binding protein	261	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	31.8%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP90839 (show subtarget assignments)	8	purified	Cj0641	15792001		ATP-NAD kinase, putative [Campylobacter ...	286	Predicted Essential	Community Requests	2AN1	31.9%	Campylobacter jejuni

IDP04681 (show subtarget assignments)	1	soluble	GBAA3131	47528422	adhB	alcohol dehydrogenase, zinc-containing [...	377	virulence factor; putative drug target function;	Phase 4: April 2009	1KOL	31.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP01879 (show subtarget assignments)	1	cloned	FTT1804c	56708790	rng	ribonuclease G [Francisella tularensis s...	498	Conserved; Drug target functions	Phase 3: June 2008	2BX2	31.9%	Francisella tularensis	Cellular processesTranscription	Cell divisionRNA processing

IDP91941 (show subtarget assignments)	8	selected	SpneCM_010100000177	298254016		ABC transporter, ATP-binding/permease pr...	588	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3B5X	31.9%	Streptococcus pneumoniae

IDP04262 (show subtarget assignments)	1	cloned	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05504 (show subtarget assignments)	1	soluble	CD0869	126698446	modA	putative molybdenum ABC transporter,subs...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	31.9%	Clostridium difficile	Transport and binding proteins: Anions

IDP91089 (show subtarget assignments)	8	cloned	NT06FT0892	0			323	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	31.9%	Francisella tularensis	Energy metabolism: Sugars

IDP91185 (show subtarget assignments)	8	cloned	AAC46367	2352978			477	virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...	Community Requests	1NY5	31.9%	Vibrio cholerae

IDP05085 (show subtarget assignments)	1	soluble	Z4863	12518151		putative 3-oxoacyl-[ACP] synthase [Esche...	389	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3KZU	31.9%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05765 (show subtarget assignments)	1	soluble	lmo2812	16804849	-	hypothetical protein lmo2812 [Listeria m...	272	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IT9	32%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05722 (show subtarget assignments)	1	purified	BA_2954	30257545	tyrA	prephenate dehydrogenase [Bacillus anthr...	378	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DZB	32%	Bacillus anthracis	Amino acid biosynthesis: Aromatic amino acid family

IDP91070 (show subtarget assignments)	8	cloned	RP205	15604078		multidrug resistance transporter ATM1 [R...	609	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	32%	Rickettsia prowazekii

IDP00942 (show subtarget assignments)	1	purified	STM0857	16764219		putative acyl-CoA dehydrogenase	387	Essential Gene	Phase 2: March 2008	3MPI	32%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP91279 (show subtarget assignments)	8	selected	NT05BA4913	49181643		DNA-binding response regulator [Bacillus...	231	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2OQR	32%	Bacillus anthracis

IDP90352 (show subtarget assignments)	8	expressed	CT262	15604983		hypothetical protein CT262 [Chlamydia tr...	256	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2CZL	32%	Chlamydia trachomatis

IDP00704 (show subtarget assignments)	1	expressed	SACOL0264	57286724		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	32%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00330 (show subtarget assignments)	1	soluble	Cj0345	15791713	trpE	putative anthranilate synthase component...	416	Drug Target Function	Phase 2: March 2008	1QDL	32%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP01953 (show subtarget assignments)	1	soluble	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00614 (show subtarget assignments)	1	purified	SACOL2109	57286325		modification methylase, HemK family	278	Drug Target Function	Phase 2: March 2008	1T43	32%	Staphylococcus aureus	Unknown function	General

IDP00119 (show subtarget assignments)	1	soluble	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP04235 (show subtarget assignments)	1	cloned	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP05497 (show subtarget assignments)	1	cloned	CD0241	126697812		phosphoserine phosphatase [Clostridium d...	205	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5S	32.1%	Clostridium difficile	Amino acid biosynthesis: Serine family

IDP02168 (show subtarget assignments)	1	expressed	CBU_1289	29541857	dnaJ	chaperone protein dnaJ [Coxiella burneti...	374	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	32.1%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP90197 (show subtarget assignments)	8	soluble	AAM13645.1	20153184	CPXV206 CDS	CPXV206 protein	285	serine-threonine kinase	Community Requests	2KTY	32.1%	Cowpox virus	Unknown function	0

IDP90654 (show subtarget assignments)	8	expressed	YPO0474	16120803	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Predicted Essential	Community Requests	1MRZ	32.1%	Yersinia pestis

IDP02011 (show subtarget assignments)	1	cloned	STM2340	16765667		putative transketolase [Salmonella typhi...	317	Conserved; Drug target functions	Phase 3: June 2008	3MOS	32.1%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP00764
(show subtarget assignments)

1

expressed

SACOL0447

57286820

phosphoglycerate mutase family protein

193

Drug Target Function

Phase 2: March 2008

1C7Z

31.1%

Staphylococcus aureus

Unknown function

General

IDP91356
(show subtarget assignments)

8

cloned

VV1_2923

27366200

DNA-binding protein H-NS [Vibrio vulnifi...

135

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1OV9

31.1%

Vibrio vulnificus

IDP02618
(show subtarget assignments)

1

cloned

STM2205

16765535

fruK

1-phosphofructokinase [Salmonella typhim...

312

Conserved; Drug target functions

Phase 3: June 2008

3CQD

31.1%

Salmonella enterica

Energy metabolism

Glycolysis/gluconeogenesis

IDP91074
(show subtarget assignments)

8

cloned

MSMEG_5659

118469658

ABC transporter, ATP-binding protein [My...

610

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

31.1%

Mycobacterium smegmatis

IDP01752
(show subtarget assignments)

1

selected

GBAA5282

47778383

nprB

neutral protease B [Bacillus anthracis s...

547

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1KEI

31.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05542
(show subtarget assignments)

1

cloned

Cj0508

6967973

pbpA

hypothetical protein Cj0504c [Campylobac...

643

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FWL

31.1%

Campylobacter jejuni

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00069
(show subtarget assignments)

1

purified

NTL01ST0342

16418853

STM0352

putative cation efflux pump

408

Virulence

Phase 1: October 2007

1T5E

31.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP05713
(show subtarget assignments)

1

cloned

BA_0189

30253696

oligopeptide ABC transporter, oligopepti...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP91402
(show subtarget assignments)

8

soluble

VV1_1001

27364435

ABC-type amino acid transport, signal tr...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GGG

31.2%

Vibrio vulnificus

IDP05742
(show subtarget assignments)

1

cloned

CD2655

126700269

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

457

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1GG4

31.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00053
(show subtarget assignments)

1

soluble

BA_3536

30258071

phenazine biosynthesis protein, PhzF fam...

285

Virulence

Phase 1: October 2007

1QY9

31.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00500
(show subtarget assignments)

1

purified

YPO1784

16122038

putative copper resistance protein

128

Conserved Gene / Pathway

Phase 2: March 2008

1IX2

31.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP02739
(show subtarget assignments)

1

soluble

FTT1321

56708378

peptidase M16 family protein [Francisell...

417

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AMI

31.2%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01870
(show subtarget assignments)

1

cloned

GBAA5710

47531047

serine protease [Bacillus anthracis str....

391

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GCN

31.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91923
(show subtarget assignments)

8

selected

SpneCM_010100002081

298254388

hypothetical protein SpneCM_02081 [Strep...

170

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1S3R

31.2%

Streptococcus pneumoniae

IDP02040
(show subtarget assignments)

1

expressed

GBAA4637

47529935

relA

GTP pyrophosphokinase [Bacillus anthraci...

727

CONSERVED. Additional information: It is responsible for a down-regulation of RN...

Phase 3: June 2008

1VJ7

31.2%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

N/A

IDP00837
(show subtarget assignments)

1

soluble

SACOL2735

57285289

chromosome partioning protein, ParB fami...

279

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

31.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP01404
(show subtarget assignments)

1

soluble

VC0856

15640872

dnaJ protein

381

Conserved Gene / Pathway

Phase 2: March 2008

3LZ8

31.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP02391
(show subtarget assignments)

1

cloned

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP04546
(show subtarget assignments)

1

cloned

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP02117
(show subtarget assignments)

1

purified

STM4356

16767602

yjeF

hypothetical protein STM4356 [Salmonella...

515

Conserved; Drug target functions

Phase 3: June 2008

2AX3

31.3%

Salmonella enterica

Unknown function

General

IDP00405
(show subtarget assignments)

1

soluble

YPO4025

16124148

putative iron ABC transporter, ATP-bindi...

252

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.3%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP02497
(show subtarget assignments)

1

cloned

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

1FCJ

31.3%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP05730
(show subtarget assignments)

1

soluble

CD0675

126698254

putative acetyltransferase [Clostridium ...

166

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2GE3

31.3%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP01779
(show subtarget assignments)

1

soluble

CBU_0366

29540977

phoR

sensor histidine kinase PhoR protein, pu...

252

Conserved; Drug target functions

Phase 3: June 2008

2C2A

31.3%

Coxiella burnetii

Signal transduction

Two-component systems

IDP05387
(show subtarget assignments)

1

soluble

BA_2041

30256692

putative oligopeptide ABC transporter, o...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP00850
(show subtarget assignments)

1

soluble

SACOL2389

57285120

transcriptional regulatory protein DegU,...

217

Conserved Gene / Pathway

Phase 2: March 2008

1A04

31.3%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP01164
(show subtarget assignments)

1

soluble

BA_5600

30260056

ABC transporter, ATP-binding protein

300

Conserved Gene / Pathway

Phase 2: March 2008

2YYZ

31.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00967
(show subtarget assignments)

1

purified

STM1559

16764903

putative glycosyl hydrolase

842

Essential Gene

Phase 2: March 2008

3HJE

31.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91075
(show subtarget assignments)

8

cloned

jhp0343

15611411

msbA

multi-drug resistance protein [Helicobac...

551

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

31.4%

Helicobacter pylori

IDP90147
(show subtarget assignments)

8

cloned

MPXV_ZAI1979_005_194

68449266

kelch-like protein [Monkeypox virus]

70

similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R

Community Requests

2Q81

31.4%

Monkeypox virus

IDP00954
(show subtarget assignments)

1

purified

STM1189

16764544

maf

Maf-like protein

194

Essential Gene

Phase 2: March 2008

1EX2

31.4%

Salmonella enterica

Cellular processes

Cell division

IDP91272
(show subtarget assignments)

8

selected

NT05BA3926

49180681

RNA polymerase sigma-29 factor [Bacillus...

239

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L0O

31.4%

Bacillus anthracis

IDP02566
(show subtarget assignments)

1

purified

GBAA3033

50196939

adP-2

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

31.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00170
(show subtarget assignments)

1

soluble

VCA0865

15601620

hap

hemagglutinin/protease

609

Virulence

Phase 1: October 2007

1EZM

31.4%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP90509
(show subtarget assignments)

8

purified

Cj0347

15791715

trpF

N-(5'phosphoribosyl)anthranilate isomera...

199

Predicted Essential

Community Requests

1DL3

31.4%

Campylobacter jejuni

IDP01781
(show subtarget assignments)

1

expressed

Cj1616

15792921

chuC

hemin ABC transporter, ATP-binding prote...

258

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

31.4%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01351
(show subtarget assignments)

1

cloned

VCA0387

15601150

toxin resistance protein

169

Conserved Gene / Pathway

Phase 2: March 2008

1YVO

31.4%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP00333
(show subtarget assignments)

1

crystallized

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91540
(show subtarget assignments)

8

selected

FTN_0549

118423054

sspA

stringent starvation protein A [Francise...

210

virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.

Community Requests

3LYK

31.4%

Francisella novicida

IDP02606
(show subtarget assignments)

1

purified

lmo0006

16802054

gyrB

DNA gyrase subunit B [Listeria monocytog...

646

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

1EI1

31.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP91217
(show subtarget assignments)

1

expressed

FTT_0458

56707600

sspA

stringent starvation protein A, regulato...

210

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LYK

31.4%

Francisella tularensis

IDP01929
(show subtarget assignments)

1

cloned

lmo1076

16803116

hypothetical protein lmo1076 [Listeria m...

572

Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888

Phase 3: June 2008

3FI7

31.5%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91644
(show subtarget assignments)

8

purified

NP_215861

15608485

long-chain-fatty-acid--[acyl-carrier-pro...

521

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

3PBK

31.5%

Mycobacterium tuberculosis

IDP01853
(show subtarget assignments)

1

cloned

CBU_1669

29542228

rpoS

RNA polymerase sigma factor RpoS [Coxiel...

352

Conserved; Drug target functions

Phase 3: June 2008

3IYD

31.5%

Coxiella burnetii

Transcription

Transcription factors

IDP91969
(show subtarget assignments)

8

selected

SpneCM_010100009453

298255801

peptidyl-prolyl cis-trans isomerase, cyc...

267

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2A2N

31.5%

Streptococcus pneumoniae

IDP90688
(show subtarget assignments)

8

purified

Cj1595

15792900

rpoA

DNA-directed RNA polymerase subunit alph...

337

Predicted Essential

Community Requests

3IYD

31.5%

Campylobacter jejuni

IDP01356
(show subtarget assignments)

1

soluble

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01060
(show subtarget assignments)

1

crystallized

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01006
(show subtarget assignments)

1

soluble

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP05255
(show subtarget assignments)

1

purified

SACOL0663

57650073

argS

arginyl-tRNA synthetase [Staphylococcus ...

553

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP00215
(show subtarget assignments)

1

cloned

YPO2295

16122519

-

haloacid dehalogenase-like hydrolase fam...

224

Virulence

Phase 1: October 2007

3ED5

31.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP91080
(show subtarget assignments)

8

cloned

Cj0803

6968244

msbA

lipid export ABC transport protein

580

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

31.6%

Campylobacter jejuni

IDP05228
(show subtarget assignments)

1

soluble

lmo0971

16803011

dltD

DltD protein for D-alanine esterificatio...

380

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BMA

31.6%

Listeria monocytogenes

Cell envelope: Other

IDP01654
(show subtarget assignments)

1

expressed

STM1259

16764611

putative ABC-type transport system ATPas...

196

Conserved; Drug target functions

Phase 3: June 2008

1Z47

31.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP90167
(show subtarget assignments)

8

purified

CD1838

123066836

Shikimate kinase

177

Potential drug target. Shikimate pathway enzyme

Community Requests

2PT5

31.6%

Clostridium difficile

IDP02719
(show subtarget assignments)

1

cloned

lmo0262

16802308

inlG

internalin G [Listeria monocytogenes EGD...

490

Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815

Phase 3: June 2008

1M9S

31.6%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP02452
(show subtarget assignments)

1

purified

GBAA3312

47528597

diaminobutyrate--2-oxoglutarate aminotra...

424

Conserved; Essential; Drug target functions

Phase 3: June 2008

2EH6

31.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP00709
(show subtarget assignments)

1

soluble

SACOL0798

57285759

iron compound ABC transporter, ATP-bindi...

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

31.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP90946
(show subtarget assignments)

8

cloned

BP1878

33592926

bvgA

virulence factors transcription regulato...

209

BvgA is the transcriptional activator for all known virulence genes in the human...

Community Requests

3C3W

31.6%

Bordetella pertussis

IDP01245
(show subtarget assignments)

1

cloned

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222
(show subtarget assignments)

1

purified

BA_4049

33301352

UDP-N-acetylglucosamine--N-acetylmuramyl...

364

Drug Target Function

Phase 2: March 2008

1F0K

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00634
(show subtarget assignments)

1

purified

SACOL1722

57284733

tig

trigger factor

433

Drug Target Function

Phase 2: March 2008

1W26

31.6%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP05766
(show subtarget assignments)

1

expressed

S0723

30040469

putative helicase [Shigella flexneri 2a ...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2R6A

31.7%

Shigella flexneri

DNA metabolism: DNA replication, recombination, and repair

IDP90529
(show subtarget assignments)

8

soluble

YPO1127

16121427

nicA

quinolinate synthetase

353

Predicted Essential

Community Requests

2QS0

31.7%

Yersinia pestis

IDP02469
(show subtarget assignments)

1

cloned

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00732
(show subtarget assignments)

1

purified

SACOL2473

57286467

peptide ABC transporter, ATP-binding pro...

271

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

31.7%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00724
(show subtarget assignments)

1

purified

SACOL1822

57286255

arsR

arsenical resistance operon repressor

104

Conserved Gene / Pathway

Phase 2: March 2008

1R1T

31.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00155
(show subtarget assignments)

1

purified

VC0405

15640432

mshE

MSHA biogenesis protein MshE

575

Virulence

Phase 1: October 2007

1P9R

31.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00518
(show subtarget assignments)

1

cloned

YPO1566

16121836

putative hydrolase

280

Virulence Associated Factor

Phase 2: March 2008

3QDF

31.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP02376
(show subtarget assignments)

1

cloned

FTT0451

56707593

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

416

Conserved; Drug target functions

Phase 3: June 2008

1E0D

31.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05453
(show subtarget assignments)

1

purified

BAS5213

49188199

-

arginyl-tRNA synthetase [Bacillus anthra...

556

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.8%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP04136
(show subtarget assignments)

1

purified

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP00721
(show subtarget assignments)

1

expressed

SACOL1613

57286135

ABC transporter, ATP-binding protein

261

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

31.8%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP90839
(show subtarget assignments)

8

purified

Cj0641

15792001

ATP-NAD kinase, putative [Campylobacter ...

286

Predicted Essential

Community Requests

2AN1

31.9%

Campylobacter jejuni

IDP04681
(show subtarget assignments)

1

soluble

GBAA3131

47528422

adhB

alcohol dehydrogenase, zinc-containing [...

377

virulence factor; putative drug target function;

Phase 4: April 2009

1KOL

31.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP01879
(show subtarget assignments)

1

cloned

FTT1804c

56708790

rng

ribonuclease G [Francisella tularensis s...

498

Conserved; Drug target functions

Phase 3: June 2008

2BX2

31.9%

Francisella tularensis

Cellular processesTranscription

Cell divisionRNA processing

IDP91941
(show subtarget assignments)

8

selected

SpneCM_010100000177

298254016

ABC transporter, ATP-binding/permease pr...

588

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3B5X

31.9%

Streptococcus pneumoniae

IDP04262
(show subtarget assignments)

1

cloned

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05504
(show subtarget assignments)

1

soluble

CD0869

126698446

modA

putative molybdenum ABC transporter,subs...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

31.9%

Clostridium difficile

Transport and binding proteins: Anions

IDP91089
(show subtarget assignments)

8

cloned

NT06FT0892

0

323

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

31.9%

Francisella tularensis

Energy metabolism: Sugars

IDP91185
(show subtarget assignments)

8

cloned

AAC46367

2352978

477

virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...

Community Requests

1NY5

31.9%

Vibrio cholerae

IDP05085
(show subtarget assignments)

1

soluble

Z4863

12518151

putative 3-oxoacyl-[ACP] synthase [Esche...

389

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3KZU

31.9%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05765
(show subtarget assignments)

1

soluble

lmo2812

16804849

-

hypothetical protein lmo2812 [Listeria m...

272

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IT9

32%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05722
(show subtarget assignments)

1

purified

BA_2954

30257545

tyrA

prephenate dehydrogenase [Bacillus anthr...

378

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DZB

32%

Bacillus anthracis

Amino acid biosynthesis: Aromatic amino acid family

IDP91070
(show subtarget assignments)

8

cloned

RP205

15604078

multidrug resistance transporter ATM1 [R...

609

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

32%

Rickettsia prowazekii

IDP00942
(show subtarget assignments)

1

purified

STM0857

16764219

putative acyl-CoA dehydrogenase

387

Essential Gene

Phase 2: March 2008

3MPI

32%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP91279
(show subtarget assignments)

8

selected

NT05BA4913

49181643

DNA-binding response regulator [Bacillus...

231

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2OQR

32%

Bacillus anthracis

IDP90352
(show subtarget assignments)

8

expressed

CT262

15604983

hypothetical protein CT262 [Chlamydia tr...

256

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2CZL

32%

Chlamydia trachomatis

IDP00704
(show subtarget assignments)

1

expressed

SACOL0264

57286724

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

32%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00330
(show subtarget assignments)

1

soluble

Cj0345

15791713

trpE

putative anthranilate synthase component...

416

Drug Target Function

Phase 2: March 2008

1QDL

32%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP01953
(show subtarget assignments)

1

soluble

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00614
(show subtarget assignments)

1

purified

SACOL2109

57286325

modification methylase, HemK family

278

Drug Target Function

Phase 2: March 2008

1T43

32%

Staphylococcus aureus

Unknown function

General

IDP00119
(show subtarget assignments)

1

soluble

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP04235
(show subtarget assignments)

1

cloned

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP05497
(show subtarget assignments)

1

cloned

CD0241

126697812

phosphoserine phosphatase [Clostridium d...

205

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5S

32.1%

Clostridium difficile

Amino acid biosynthesis: Serine family

IDP02168
(show subtarget assignments)

1

expressed

CBU_1289

29541857

dnaJ

chaperone protein dnaJ [Coxiella burneti...

374

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

32.1%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP90197
(show subtarget assignments)

8

soluble

AAM13645.1

20153184

CPXV206 CDS

CPXV206 protein

285

serine-threonine kinase

Community Requests

2KTY

32.1%

Cowpox virus

Unknown function

0

IDP90654
(show subtarget assignments)

8

expressed

YPO0474

16120803

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Predicted Essential

Community Requests

1MRZ

32.1%

Yersinia pestis

IDP02011
(show subtarget assignments)

1

cloned

STM2340

16765667

putative transketolase [Salmonella typhi...

317

Conserved; Drug target functions

Phase 3: June 2008

3MOS

32.1%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway