Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	Stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Project	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01607 (show subtarget assignments)	1	cloned	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01608 (show subtarget assignments)	1	cloned	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01609 (show subtarget assignments)	1	crystallized	FTT1512c	56708550	dnaJ1	heat shock protein, hsp40 [Francisella t...	308	Conserved; Drug target functions	June 2008	3LZ8	34.2%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01610 (show subtarget assignments)	1	in_pdb 3I1I	GBAA4983	47778350		homoserine O-acetyltransferase [Bacillus...	374	Conserved; Involved in sporulation; Drug target functions	June 2008	3I1I	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01611 (show subtarget assignments)	1	crystallized	lmo1827	16803867	gmk	hypothetical protein lmo1827 [Listeria m...	205	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	June 2008	2J41	60.5%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01612 (show subtarget assignments)	1	cloned	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01613 (show subtarget assignments)	1	purified	STM1927	16765269	yecG	universal stress protein UspC [Salmonell...	142	Conserved; Drug target functions	June 2008	1JMV	35.2%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP01614 (show subtarget assignments)	1	purified	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01615 (show subtarget assignments)	1	purified	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01616 (show subtarget assignments)	1	in_pdb 3EG7	VC_A0947	9658384		spermidine n1-acetyltransferase [Vibrio ...	173	CONSERVED	June 2008	3EG7	100%	Vibrio cholerae	N/A	N/A

IDP01619 (show subtarget assignments)	1	expressed	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01620 (show subtarget assignments)	1	cloned	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01621 (show subtarget assignments)	1	cloned	STM1984	16765321	yodD	putative cytoplasmic protein [Salmonella...	75	Conserved; Drug target functions	June 2008			Salmonella enterica	Unknown function	General

IDP01622 (show subtarget assignments)	1	cloned	STM4396	16767642	ytfB	putative cell envelope opacity-associate...	211	Conserved; Drug target functions	June 2008			Salmonella enterica	Unknown function	General

IDP01623 (show subtarget assignments)	1	cloned	GBAA5019	47530321	pckA	phosphoenolpyruvate carboxykinase [Bacil...	528	Conserved; Essential; Drug target functions	June 2008	1J3B	52.8%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01624 (show subtarget assignments)	1	expressed	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	June 2008	2AI7	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01625 (show subtarget assignments)	1	expressed	FTT1761	56708756		hypothetical protein FTT1761 [Francisell...	239	Drug Target	June 2008			Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP01626 (show subtarget assignments)	1	cloned	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01627 (show subtarget assignments)	1	cloned	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01628 (show subtarget assignments)	1	cloned	CBU_1909	29542466	rpoH	RNA polymerase sigma-32 factor [Coxiella...	288	Conserved; Drug target functions	June 2008	3IYD	26.4%	Coxiella burnetii	Protein synthesis	Translation factors

IDP01629 (show subtarget assignments)	1	cloned	CBU_1903	29542460	ftsY	signal recognition particle-docking prot...	324	Conserved; Drug target functions	June 2008	2QY9	56.2%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01630 (show subtarget assignments)	1	purified	CBU_1964	29542519	hemK	protein methyltransferase HemK [Coxiella...	277	Conserved; Drug target functions	June 2008	1T43	42.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01631 (show subtarget assignments)	1	soluble	CBU_2024	29542577		cystathionine beta-synthase, putative [C...	316	Conserved; Drug target functions	June 2008	1JBQ	60.9%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP01632 (show subtarget assignments)	1	cloned	FTT1571c	56708597	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	337	Drug Target	June 2008	3EH0	45.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01633 (show subtarget assignments)	1	soluble	FTT1569c	56708595	lpxA	UDP-N-acetylglucosamine acyltransferase ...	259	Conserved; Drug target functions	June 2008	1LXA	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01634 (show subtarget assignments)	1	in_pdb 3O7M	GBAA5074	47530373	hpt-2	hypoxanthine-guanine phosphoribosyltrans...	183	Conserved; Essential; Drug target functions	June 2008	3O7M	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01635 (show subtarget assignments)	1	soluble	GBAA4844	47530139	pfkA	6-phosphofructokinase [Bacillus anthraci...	319	Conserved; Involved in sporulation; Drug target functions	June 2008	6PFK	86.5%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01636 (show subtarget assignments)	1	cloned	Cj1144c	6968572	Cj1138	putative galactosyltransferase [Campylob...	197	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01637 (show subtarget assignments)	1	crystallized	GBAA5111	47530413	menD	2-succinyl-6-hydroxy-2,4-cyclohexadiene-...	584	Conserved; Drug target functions	June 2008	2X7J	46.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01638 (show subtarget assignments)	1	soluble	CBU_0312	29540925	folD	folD bifunctional protein [Coxiella burn...	283	Conserved; Drug target functions	June 2008	1B0A	59.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01639 (show subtarget assignments)	1	cloned	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01640 (show subtarget assignments)	1	purified	GBAA4357	47529653		short chain dehydrogenase/reductase fami...	264	Conserved; Essential;	June 2008	1XG5	32.6%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01641 (show subtarget assignments)	1	cloned	CBU_0481	29541087	artP	amino acid ABC transporter, ATP-binding ...	250	Conserved; Drug target functions	June 2008	2OLJ	48%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01642 (show subtarget assignments)	1	cloned	Cj1150c	6968577	neuA1	acylneuraminate cytidylyltransferase [Ca...	461	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	June 2008	2AWD	15.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01643 (show subtarget assignments)	1	crystallized	YPO2892	16123083	hscA	chaperone protein HscA [Yersinia pestis ...	650	CD; Drug target functions	June 2008	2KHO	37.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP01644 (show subtarget assignments)	1	cloned	FTT0626	56707751	lon	DNA-binding, ATP-dependent protease La [...	774	Conserved; Drug target functions; Drug target motif	June 2008	3M6A	37.7%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01645 (show subtarget assignments)	1	soluble	lmo2509	16804547	prfB	peptide chain release factor 2 [Listeria...	327	Predicted virulence-Regulation; Possible Vaccine Candidate	June 2008	2B9M	49.2%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP01646 (show subtarget assignments)	1	soluble	GBAA5119	47530423	glgP	glycogen phosphorylase [Bacillus anthrac...	802	Conserved; Involved in sporulation; Drug target functions	June 2008	1AXR	46.5%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01647 (show subtarget assignments)	1	expressed	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01648 (show subtarget assignments)	1	cloned	YPO2944	16123127		putative pili chaperone protein [Yersini...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	June 2008	1N0L	29%	Yersinia pestis	Cell envelope	Surface structures

IDP01649 (show subtarget assignments)	1	expressed	CBU_0796	29541390		HIT family protein [Coxiella burnetii RS...	113	Conserved; Drug target functions	June 2008	1AV5	49.6%	Coxiella burnetii	Unknown function	General

IDP01650 (show subtarget assignments)	1	in_pdb 3IFS	GBAA5130	47530435	pgi	glucose-6-phosphate isomerase [Bacillus ...	450	Essential; Involved in sporulation; Drug target functions	June 2008	3IFS	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01651 (show subtarget assignments)	1	cloned	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01652 (show subtarget assignments)	1	purified	FTT1695	56708704	groES	co-chaperonin GroES [Francisella tularen...	95	Conserved; Drug target functions	June 2008	1AON	56.8%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01653 (show subtarget assignments)	1	cloned	GBAA4538	47529835	dnaJ	chaperone protein dnaJ [Bacillus anthrac...	371	Conserved; Involved in sporulation; Drug target functions	June 2008	3LZ8	34%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01654 (show subtarget assignments)	1	expressed	STM1259	16764611		putative ABC-type transport system ATPas...	196	Conserved; Drug target functions	June 2008	1Z47	31.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01655 (show subtarget assignments)	1	purified	FTT0721c	56707839	katG	peroxidase/catalase [Francisella tularen...	741	Drug Target	June 2008	1MWV	53.3%	Francisella tularensis	Cellular processes	Detoxification

IDP01656 (show subtarget assignments)	1	purified	lmo2537	16804575		hypothetical protein lmo2537 [Listeria m...	379	Known Essential Genes; PMID:16952950	June 2008	3BEO	65.4%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01657 (show subtarget assignments)	1	cloned	YPO3061	16123238	dapX	lipoprotein [Yersinia pestis CO92]	352	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	June 2008			Yersinia pestis	Unclassified	Role category not yet assigned

IDP01658 (show subtarget assignments)	1	purified	Cj0059c	6967557	fliY	putative flagellar motor switch protein ...	280	Known Predicted virulence-flagella; PMID:8478066	June 2008	1O6A	15.4%	Campylobacter jejuni	Cell envelope	Other

IDP01659 (show subtarget assignments)	1	crystallized	CBU_1739	29542296		tetrapyrrole (Corrin/Porphyrin) methylas...	285	Conserved; Drug target functions	June 2008	3KWP	42.1%	Coxiella burnetii	Unknown function	General

IDP01660 (show subtarget assignments)	1	expressed	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01661 (show subtarget assignments)	1	soluble	GBAA4609	47529906		U32 family peptidase [Bacillus anthracis...	426	Drug target motif; Drug target functions	June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01662 (show subtarget assignments)	1	purified	lmo2583	16804621		hypothetical protein lmo2583 [Listeria m...	225	Predicted virulence-Iron Scavenging Mechanisms	June 2008	2OQR	39.1%	Listeria monocytogenes	Regulatory functions	Other

IDP01663 (show subtarget assignments)	1	purified	GBAA4696	47529995	hemC	porphobilinogen deaminase [Bacillus anth...	309	Conserved; Drug target functions	June 2008	1AH5	46.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01664 (show subtarget assignments)	1	purified	Cj0064c	6967562	flhF	flagellar biosynthesis protein [Campylob...	484	Known Predicted virulence-flagella; PMID:8478066	June 2008	1ZU4	17.4%	Campylobacter jejuni	Cell envelope	Surface structures

IDP01665 (show subtarget assignments)	1	soluble	YPO3001	16123182		putative pyridine nucleotide-disulphide ...	548	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	June 2008	3ICR	58%	Yersinia pestis	Cellular processes	Detoxification

IDP01666 (show subtarget assignments)	1	soluble	GBAA4704	47530003	clpX	ATP-dependent protease ATP-binding subun...	419	Drug target motif; Involved in sporulation; Drug target functions	June 2008	3HTE	52.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01667 (show subtarget assignments)	1	expressed	FTT1782c	56708774	yjjK	putative ABC transporter ATP-binding pro...	559	Conserved; Drug target functions	June 2008	1YQT	27.3%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01668 (show subtarget assignments)	1	soluble	GBAA0060	47525314		hypothetical protein GBAA0060 [Bacillus ...	160	Essential;	June 2008	2K4K	29.4%	Bacillus anthracis	Unknown function	General

IDP01669 (show subtarget assignments)	1	cloned	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01670 (show subtarget assignments)	1	cloned	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01671 (show subtarget assignments)	1	cloned	YPO3012	16123191	cysA	sulfate/thiosulfate transporter subunit ...	363	Conserved; CD; Drug target functions	June 2008	1Z47	39.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01672 (show subtarget assignments)	1	soluble	GBAA5133	47530438		hypothetical protein GBAA5133 [Bacillus ...	396	Conserved; Essential; Involved in sporulation;	June 2008	1DJU	48.2%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01673 (show subtarget assignments)	1	soluble	GBAA5206	47530513		M23/37 family peptidase [Bacillus anthra...	327	Drug target motif; Conserved; Vaccine Target; Drug target functions	June 2008	1QWY	11.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01674 (show subtarget assignments)	1	cloned	lmo2543	16804581	prfA	peptide chain release factor 1 [Listeria...	358	Predicted virulence-Regulation	June 2008	1ZBT	63.7%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP01675 (show subtarget assignments)	1	soluble	GBAA5217	47530523		ABC transporter ATP-binding protein [Bac...	261	Essential; Involved in sporulation; Drug target functions	June 2008	2D2E	57.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01676 (show subtarget assignments)	1	cloned	CBU_0869	29541462	alr	alanine racemase [Coxiella burnetii RSA ...	364	Conserved; Drug target functions	June 2008	2RJG	42.6%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01677 (show subtarget assignments)	1	soluble	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP01678 (show subtarget assignments)	1	cloned	GBAA5591	47530913		cardiolipin synthetase domain-containing...	397	Drug target motif; Involved in sporulation;	June 2008			Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01679 (show subtarget assignments)	1	cloned	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP01680 (show subtarget assignments)	0	work_stopped	VC0902	161582018	queF	7-cyano-7-deazaguanine reductase [Vibrio...	281	Conserved; Drug target homolg; Drug target functions	June 2008	3BP1	100%	Vibrio cholerae	N/A	N/A

IDP01681 (show subtarget assignments)	1	cloned	GBAA4795	47530092		hypothetical protein GBAA4795 [Bacillus ...	572	Conserved; Essential; Involved in sporulation;	June 2008	2W9M	33.6%	Bacillus anthracis	Unknown function	General

IDP01682 (show subtarget assignments)	1	cloned	GBAA5104	47530405		D-alanyl-D-alanine carboxypeptidase fami...	286	Drug target motif; Drug target functions	June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01683 (show subtarget assignments)	1	expressed	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01684 (show subtarget assignments)	1	soluble	YPO3559	16123703		hypothetical protein YPO3559 [Yersinia p...	161	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	June 2008			Yersinia pestis	Cell envelope	Other

IDP01685 (show subtarget assignments)	1	purified	FTT0757	56707872	galU	UTP--glucose-1-phosphate uridylyltransfe...	287	Conserved; Drug target functions	June 2008	2E3D	47.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01686 (show subtarget assignments)	1	cloned	Cj0804	6968245	ruvA	putative Holliday junction DNA helicase ...	352	Possible Vaccine Candidate; Predicted Essential-Modeling	June 2008	1UUM	40.3%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01687 (show subtarget assignments)	1	cloned	Cj0740	6968192	Cj0735	putative periplasmic protein [Campylobac...	54	Predicted virulence-Adhesion of Campylobacter	June 2008			Campylobacter jejuni	Transport and binding proteins	Amino acids, peptides and amines

IDP01688 (show subtarget assignments)	0	work_stopped	Cj1313	6968739	Cj1305c	hypothetical protein Cj1305c (617 family...	157	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	June 2008	3EG7	22.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01689 (show subtarget assignments)	1	soluble	CBU_1708	29542266	sodB	superoxide dismutase (fe) [Coxiella burn...	193	Conserved; Drug target functions	June 2008	3SDP	63.2%	Coxiella burnetii	Cellular processes	Detoxification

IDP01690 (show subtarget assignments)	1	soluble	CBU_1719	29542277	groES	chaperonin, 10 kDa [Coxiella burnetii RS...	96	Conserved; Drug target functions	June 2008	3NX6	58.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01691 (show subtarget assignments)	1	cloned	CBU_1575	29542135	tolR	tolR protein [Coxiella burnetii RSA 493]...	147	Conserved; Drug target functions	June 2008			Coxiella burnetii	Transport and binding proteins	Other

IDP01692 (show subtarget assignments)	1	cloned	FTT1671	56708681	ribD	riboflavin biosynthesis protein ribD [Fr...	355	Conserved; Drug target functions	June 2008	2B3Z	37.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01693 (show subtarget assignments)	1	in_pdb 3G1Z	STM4344	16767593	yjeA	lysyl-tRNA synthetase [Salmonella typhim...	325	DRUG TARGET HOMOLOG	June 2008	3G1Z	100%	Salmonella enterica	N/A	N/A

IDP01694 (show subtarget assignments)	1	purified	YPO3335	16123488	fumA	fumarate hydratase, class I [Yersinia pe...	547	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	June 2008	2ISB	10.1%	Yersinia pestis	Energy metabolism	TCA cycle

IDP01695 (show subtarget assignments)	1	expressed	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01696 (show subtarget assignments)	1	cloned	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP01697 (show subtarget assignments)	6	cloned	AAC68008	3328839	lpxB	Lipid A Disaccharide Synthase [Chlamydia...	607	LpxB is responsible for the formation of genus-specific lipolpolysaccharide epit...	June 2008			Chlamydia trachomatis	N/A	N/A

IDP01698 (show subtarget assignments)	1	purified	YPO3359	16123509	truD	tRNA pseudouridine synthase D [Yersinia ...	349	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	June 2008	1SB7	64.5%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01699 (show subtarget assignments)	1	expressed	YPO3343	16123493		extracellular solute-binding protein [Ye...	256	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	June 2008	3KBR	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01700 (show subtarget assignments)	1	expressed	CBU_1899	29542456		methyltransferase, putative [Coxiella bu...	193	Conserved; Drug target functions	June 2008	2FPO	51%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP01701 (show subtarget assignments)	1	soluble	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01702 (show subtarget assignments)	1	soluble	GBAA0261	47525520	gcP	O-sialoglycoprotein endopeptidase [Bacil...	338	Drug target motif; Conserved; Involved in sporulation; Drug target functions	June 2008	2IVN	35.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01703 (show subtarget assignments)	1	purified	Cj1317	6968743	Cj1309c	hypothetical protein Cj1309c [Campylobac...	343	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	June 2008	1XUU	35.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01704 (show subtarget assignments)	1	expressed	GBAA5215	47530521		aminotransferase, class V [Bacillus anth...	406	Conserved; Involved in sporulation; Drug target functions	June 2008	1T3I	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01705 (show subtarget assignments)	1	in_pdb 3N5M	BAS1519	49184534		aminotransferase [Bacillus anthracis str...	449	CONSERVED GENE/PATHWAY	June 2008	3N5M	99.6%	Bacillus anthracis	N/A	N/A

IDP01706 (show subtarget assignments)	1	cloned	STM1438	16764786	ydhL	putative oxidoreductase [Salmonella typh...	79	Conserved; Drug target functions	June 2008			Salmonella enterica	Unknown function	General

IDP01707 (show subtarget assignments)	1	crystallized	STM1631	16764975	sseJ	secreted effector protein [Salmonella ty...	408	VIRULENCE FACTOR	June 2008	3CXB	10%	Salmonella enterica	N/A	N/A

IDP01708 (show subtarget assignments)	1	expressed	Cj0241c	6967719	Cj0241c	putative iron-binding protein [Campyloba...	133	Predicted virulence-Iron Scavenging Mechanisms	June 2008	2AVK	26.3%	Campylobacter jejuni	Cellular processes	Other

IDP01607
(show subtarget assignments)

1

cloned

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01608
(show subtarget assignments)

1

cloned

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01609
(show subtarget assignments)

1

crystallized

FTT1512c

56708550

dnaJ1

heat shock protein, hsp40 [Francisella t...

308

Conserved; Drug target functions

June 2008

3LZ8

34.2%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01610
(show subtarget assignments)

1

in_pdb
3I1I

GBAA4983

47778350

homoserine O-acetyltransferase [Bacillus...

374

Conserved; Involved in sporulation; Drug target functions

June 2008

3I1I

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01611
(show subtarget assignments)

1

crystallized

lmo1827

16803867

gmk

hypothetical protein lmo1827 [Listeria m...

205

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

June 2008

2J41

60.5%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01612
(show subtarget assignments)

1

cloned

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01613
(show subtarget assignments)

1

purified

STM1927

16765269

yecG

universal stress protein UspC [Salmonell...

142

Conserved; Drug target functions

June 2008

1JMV

35.2%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP01614
(show subtarget assignments)

1

purified

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01615
(show subtarget assignments)

1

purified

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01616
(show subtarget assignments)

1

in_pdb
3EG7

VC_A0947

9658384

spermidine n1-acetyltransferase [Vibrio ...

173

CONSERVED

June 2008

3EG7

100%

Vibrio cholerae

N/A

IDP01619
(show subtarget assignments)

1

expressed

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01620
(show subtarget assignments)

1

cloned

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01621
(show subtarget assignments)

1

cloned

STM1984

16765321

yodD

putative cytoplasmic protein [Salmonella...

75

Conserved; Drug target functions

June 2008

Salmonella enterica

Unknown function

General

IDP01622
(show subtarget assignments)

1

cloned

STM4396

16767642

ytfB

putative cell envelope opacity-associate...

211

Conserved; Drug target functions

June 2008

Salmonella enterica

Unknown function

General

IDP01623
(show subtarget assignments)

1

cloned

GBAA5019

47530321

pckA

phosphoenolpyruvate carboxykinase [Bacil...

528

Conserved; Essential; Drug target functions

June 2008

1J3B

52.8%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01624
(show subtarget assignments)

1

expressed

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

June 2008

2AI7

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01625
(show subtarget assignments)

1

expressed

FTT1761

56708756

hypothetical protein FTT1761 [Francisell...

239

Drug Target

June 2008

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP01626
(show subtarget assignments)

1

cloned

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01627
(show subtarget assignments)

1

cloned

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP01628
(show subtarget assignments)

1

cloned

CBU_1909

29542466

rpoH

RNA polymerase sigma-32 factor [Coxiella...

288

Conserved; Drug target functions

June 2008

3IYD

26.4%

Coxiella burnetii

Protein synthesis

Translation factors

IDP01629
(show subtarget assignments)

1

cloned

CBU_1903

29542460

ftsY

signal recognition particle-docking prot...

324

Conserved; Drug target functions

June 2008

2QY9

56.2%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01630
(show subtarget assignments)

1

purified

CBU_1964

29542519

hemK

protein methyltransferase HemK [Coxiella...

277

Conserved; Drug target functions

June 2008

1T43

42.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01631
(show subtarget assignments)

1

soluble

CBU_2024

29542577

cystathionine beta-synthase, putative [C...

316

Conserved; Drug target functions

June 2008

1JBQ

60.9%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP01632
(show subtarget assignments)

1

cloned

FTT1571c

56708597

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

337

Drug Target

June 2008

3EH0

45.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01633
(show subtarget assignments)

1

soluble

FTT1569c

56708595

lpxA

UDP-N-acetylglucosamine acyltransferase ...

259

Conserved; Drug target functions

June 2008

1LXA

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01634
(show subtarget assignments)

1

in_pdb
3O7M

GBAA5074

47530373

hpt-2

hypoxanthine-guanine phosphoribosyltrans...

183

Conserved; Essential; Drug target functions

June 2008

3O7M

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01635
(show subtarget assignments)

1

soluble

GBAA4844

47530139

pfkA

6-phosphofructokinase [Bacillus anthraci...

319

Conserved; Involved in sporulation; Drug target functions

June 2008

6PFK

86.5%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01636
(show subtarget assignments)

1

cloned

Cj1144c

6968572

Cj1138

putative galactosyltransferase [Campylob...

197

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01637
(show subtarget assignments)

1

crystallized

GBAA5111

47530413

menD

2-succinyl-6-hydroxy-2,4-cyclohexadiene-...

584

Conserved; Drug target functions

June 2008

2X7J

46.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01638
(show subtarget assignments)

1

soluble

CBU_0312

29540925

folD

folD bifunctional protein [Coxiella burn...

283

Conserved; Drug target functions

June 2008

1B0A

59.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01639
(show subtarget assignments)

1

cloned

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01640
(show subtarget assignments)

1

purified

GBAA4357

47529653

short chain dehydrogenase/reductase fami...

264

Conserved; Essential;

June 2008

1XG5

32.6%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01641
(show subtarget assignments)

1

cloned

CBU_0481

29541087

artP

amino acid ABC transporter, ATP-binding ...

250

Conserved; Drug target functions

June 2008

2OLJ

48%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01642
(show subtarget assignments)

1

cloned

Cj1150c

6968577

neuA1

acylneuraminate cytidylyltransferase [Ca...

461

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

June 2008

2AWD

15.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01643
(show subtarget assignments)

1

crystallized

YPO2892

16123083

hscA

chaperone protein HscA [Yersinia pestis ...

650

CD; Drug target functions

June 2008

2KHO

37.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP01644
(show subtarget assignments)

1

cloned

FTT0626

56707751

lon

DNA-binding, ATP-dependent protease La [...

774

Conserved; Drug target functions; Drug target motif

June 2008

3M6A

37.7%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01645
(show subtarget assignments)

1

soluble

lmo2509

16804547

prfB

peptide chain release factor 2 [Listeria...

327

Predicted virulence-Regulation; Possible Vaccine Candidate

June 2008

2B9M

49.2%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP01646
(show subtarget assignments)

1

soluble

GBAA5119

47530423

glgP

glycogen phosphorylase [Bacillus anthrac...

802

Conserved; Involved in sporulation; Drug target functions

June 2008

1AXR

46.5%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01647
(show subtarget assignments)

1

expressed

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01648
(show subtarget assignments)

1

cloned

YPO2944

16123127

putative pili chaperone protein [Yersini...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

June 2008

1N0L

29%

Yersinia pestis

Cell envelope

Surface structures

IDP01649
(show subtarget assignments)

1

expressed

CBU_0796

29541390

HIT family protein [Coxiella burnetii RS...

113

Conserved; Drug target functions

June 2008

1AV5

49.6%

Coxiella burnetii

Unknown function

General

IDP01650
(show subtarget assignments)

1

in_pdb
3IFS

GBAA5130

47530435

pgi

glucose-6-phosphate isomerase [Bacillus ...

450

Essential; Involved in sporulation; Drug target functions

June 2008

3IFS

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01651
(show subtarget assignments)

1

cloned

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01652
(show subtarget assignments)

1

purified

FTT1695

56708704

groES

co-chaperonin GroES [Francisella tularen...

95

Conserved; Drug target functions

June 2008

1AON

56.8%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01653
(show subtarget assignments)

1

cloned

GBAA4538

47529835

dnaJ

chaperone protein dnaJ [Bacillus anthrac...

371

Conserved; Involved in sporulation; Drug target functions

June 2008

3LZ8

34%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01654
(show subtarget assignments)

1

expressed

STM1259

16764611

putative ABC-type transport system ATPas...

196

Conserved; Drug target functions

June 2008

1Z47

31.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01655
(show subtarget assignments)

1

purified

FTT0721c

56707839

katG

peroxidase/catalase [Francisella tularen...

741

Drug Target

June 2008

1MWV

53.3%

Francisella tularensis

Cellular processes

Detoxification

IDP01656
(show subtarget assignments)

1

purified

lmo2537

16804575

hypothetical protein lmo2537 [Listeria m...

379

Known Essential Genes; PMID:16952950

June 2008

3BEO

65.4%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01657
(show subtarget assignments)

1

cloned

YPO3061

16123238

dapX

lipoprotein [Yersinia pestis CO92]

352

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

June 2008

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01658
(show subtarget assignments)

1

purified

Cj0059c

6967557

fliY

putative flagellar motor switch protein ...

280

Known Predicted virulence-flagella; PMID:8478066

June 2008

1O6A

15.4%

Campylobacter jejuni

Cell envelope

Other

IDP01659
(show subtarget assignments)

1

crystallized

CBU_1739

29542296

tetrapyrrole (Corrin/Porphyrin) methylas...

285

Conserved; Drug target functions

June 2008

3KWP

42.1%

Coxiella burnetii

Unknown function

General

IDP01660
(show subtarget assignments)

1

expressed

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01661
(show subtarget assignments)

1

soluble

GBAA4609

47529906

U32 family peptidase [Bacillus anthracis...

426

Drug target motif; Drug target functions

June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01662
(show subtarget assignments)

1

purified

lmo2583

16804621

hypothetical protein lmo2583 [Listeria m...

225

Predicted virulence-Iron Scavenging Mechanisms

June 2008

2OQR

39.1%

Listeria monocytogenes

Regulatory functions

Other

IDP01663
(show subtarget assignments)

1

purified

GBAA4696

47529995

hemC

porphobilinogen deaminase [Bacillus anth...

309

Conserved; Drug target functions

June 2008

1AH5

46.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01664
(show subtarget assignments)

1

purified

Cj0064c

6967562

flhF

flagellar biosynthesis protein [Campylob...

484

Known Predicted virulence-flagella; PMID:8478066

June 2008

1ZU4

17.4%

Campylobacter jejuni

Cell envelope

Surface structures

IDP01665
(show subtarget assignments)

1

soluble

YPO3001

16123182

putative pyridine nucleotide-disulphide ...

548

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

June 2008

3ICR

58%

Yersinia pestis

Cellular processes

Detoxification

IDP01666
(show subtarget assignments)

1

soluble

GBAA4704

47530003

clpX

ATP-dependent protease ATP-binding subun...

419

Drug target motif; Involved in sporulation; Drug target functions

June 2008

3HTE

52.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01667
(show subtarget assignments)

1

expressed

FTT1782c

56708774

yjjK

putative ABC transporter ATP-binding pro...

559

Conserved; Drug target functions

June 2008

1YQT

27.3%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01668
(show subtarget assignments)

1

soluble

GBAA0060

47525314

hypothetical protein GBAA0060 [Bacillus ...

160

Essential;

June 2008

2K4K

29.4%

Bacillus anthracis

Unknown function

General

IDP01669
(show subtarget assignments)

1

cloned

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01670
(show subtarget assignments)

1

cloned

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01671
(show subtarget assignments)

1

cloned

YPO3012

16123191

cysA

sulfate/thiosulfate transporter subunit ...

363

Conserved; CD; Drug target functions

June 2008

1Z47

39.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01672
(show subtarget assignments)

1

soluble

GBAA5133

47530438

hypothetical protein GBAA5133 [Bacillus ...

396

Conserved; Essential; Involved in sporulation;

June 2008

1DJU

48.2%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01673
(show subtarget assignments)

1

soluble

GBAA5206

47530513

M23/37 family peptidase [Bacillus anthra...

327

Drug target motif; Conserved; Vaccine Target; Drug target functions

June 2008

1QWY

11.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01674
(show subtarget assignments)

1

cloned

lmo2543

16804581

prfA

peptide chain release factor 1 [Listeria...

358

Predicted virulence-Regulation

June 2008

1ZBT

63.7%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP01675
(show subtarget assignments)

1

soluble

GBAA5217

47530523

ABC transporter ATP-binding protein [Bac...

261

Essential; Involved in sporulation; Drug target functions

June 2008

2D2E

57.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01676
(show subtarget assignments)

1

cloned

CBU_0869

29541462

alr

alanine racemase [Coxiella burnetii RSA ...

364

Conserved; Drug target functions

June 2008

2RJG

42.6%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01677
(show subtarget assignments)

1

soluble

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP01678
(show subtarget assignments)

1

cloned

GBAA5591

47530913

cardiolipin synthetase domain-containing...

397

Drug target motif; Involved in sporulation;

June 2008

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01679
(show subtarget assignments)

1

cloned

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP01680
(show subtarget assignments)

0

work_stopped

VC0902

161582018

queF

7-cyano-7-deazaguanine reductase [Vibrio...

281

Conserved; Drug target homolg; Drug target functions

June 2008

3BP1

100%

Vibrio cholerae

N/A

IDP01681
(show subtarget assignments)

1

cloned

GBAA4795

47530092

hypothetical protein GBAA4795 [Bacillus ...

572

Conserved; Essential; Involved in sporulation;

June 2008

2W9M

33.6%

Bacillus anthracis

Unknown function

General

IDP01682
(show subtarget assignments)

1

cloned

GBAA5104

47530405

D-alanyl-D-alanine carboxypeptidase fami...

286

Drug target motif; Drug target functions

June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01683
(show subtarget assignments)

1

expressed

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01684
(show subtarget assignments)

1

soluble

YPO3559

16123703

hypothetical protein YPO3559 [Yersinia p...

161

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

June 2008

Yersinia pestis

Cell envelope

Other

IDP01685
(show subtarget assignments)

1

purified

FTT0757

56707872

galU

UTP--glucose-1-phosphate uridylyltransfe...

287

Conserved; Drug target functions

June 2008

2E3D

47.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01686
(show subtarget assignments)

1

cloned

Cj0804

6968245

ruvA

putative Holliday junction DNA helicase ...

352

Possible Vaccine Candidate; Predicted Essential-Modeling

June 2008

1UUM

40.3%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01687
(show subtarget assignments)

1

cloned

Cj0740

6968192

Cj0735

putative periplasmic protein [Campylobac...

54

Predicted virulence-Adhesion of Campylobacter

June 2008

Campylobacter jejuni

Transport and binding proteins

Amino acids, peptides and amines

IDP01688
(show subtarget assignments)

0

work_stopped

Cj1313

6968739

Cj1305c

hypothetical protein Cj1305c (617 family...

157

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

June 2008

3EG7

22.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01689
(show subtarget assignments)

1

soluble

CBU_1708

29542266

sodB

superoxide dismutase (fe) [Coxiella burn...

193

Conserved; Drug target functions

June 2008

3SDP

63.2%

Coxiella burnetii

Cellular processes

Detoxification

IDP01690
(show subtarget assignments)

1

soluble

CBU_1719

29542277

groES

chaperonin, 10 kDa [Coxiella burnetii RS...

96

Conserved; Drug target functions

June 2008

3NX6

58.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01691
(show subtarget assignments)

1

cloned

CBU_1575

29542135

tolR

tolR protein [Coxiella burnetii RSA 493]...

147

Conserved; Drug target functions

June 2008

Coxiella burnetii

Transport and binding proteins

Other

IDP01692
(show subtarget assignments)

1

cloned

FTT1671

56708681

ribD

riboflavin biosynthesis protein ribD [Fr...

355

Conserved; Drug target functions

June 2008

2B3Z

37.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01693
(show subtarget assignments)

1

in_pdb
3G1Z

STM4344

16767593

yjeA

lysyl-tRNA synthetase [Salmonella typhim...

325

DRUG TARGET HOMOLOG

June 2008

3G1Z

100%

Salmonella enterica

N/A

IDP01694
(show subtarget assignments)

1

purified

YPO3335

16123488

fumA

fumarate hydratase, class I [Yersinia pe...

547

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

June 2008

2ISB

10.1%

Yersinia pestis

Energy metabolism

TCA cycle

IDP01695
(show subtarget assignments)

1

expressed

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01696
(show subtarget assignments)

1

cloned

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP01697
(show subtarget assignments)

6

cloned

AAC68008

3328839

lpxB

Lipid A Disaccharide Synthase [Chlamydia...

607

LpxB is responsible for the formation of genus-specific lipolpolysaccharide epit...

June 2008

Chlamydia trachomatis

N/A

IDP01698
(show subtarget assignments)

1

purified

YPO3359

16123509

truD

tRNA pseudouridine synthase D [Yersinia ...

349

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

June 2008

1SB7

64.5%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01699
(show subtarget assignments)

1

expressed

YPO3343

16123493

extracellular solute-binding protein [Ye...

256

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

June 2008

3KBR

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01700
(show subtarget assignments)

1

expressed

CBU_1899

29542456

methyltransferase, putative [Coxiella bu...

193

Conserved; Drug target functions

June 2008

2FPO

51%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP01701
(show subtarget assignments)

1

soluble

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01702
(show subtarget assignments)

1

soluble

GBAA0261

47525520

gcP

O-sialoglycoprotein endopeptidase [Bacil...

338

Drug target motif; Conserved; Involved in sporulation; Drug target functions

June 2008

2IVN

35.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01703
(show subtarget assignments)

1

purified

Cj1317

6968743

Cj1309c

hypothetical protein Cj1309c [Campylobac...

343

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

June 2008

1XUU

35.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01704
(show subtarget assignments)

1

expressed

GBAA5215

47530521

aminotransferase, class V [Bacillus anth...

406

Conserved; Involved in sporulation; Drug target functions

June 2008

1T3I

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01705
(show subtarget assignments)

1

in_pdb
3N5M

BAS1519

49184534

aminotransferase [Bacillus anthracis str...

449

CONSERVED GENE/PATHWAY

June 2008

3N5M

99.6%

Bacillus anthracis

N/A

IDP01706
(show subtarget assignments)

1

cloned

STM1438

16764786

ydhL

putative oxidoreductase [Salmonella typh...

79

Conserved; Drug target functions

June 2008

Salmonella enterica

Unknown function

General

IDP01707
(show subtarget assignments)

1

crystallized

STM1631

16764975

sseJ

secreted effector protein [Salmonella ty...

408

VIRULENCE FACTOR

June 2008

3CXB

10%

Salmonella enterica

N/A

IDP01708
(show subtarget assignments)

1

expressed

Cj0241c

6967719

Cj0241c

putative iron-binding protein [Campyloba...

133

Predicted virulence-Iron Scavenging Mechanisms

June 2008

2AVK

26.3%

Campylobacter jejuni

Cellular processes

Other

Targets