Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01664 (show subtarget assignments)	1	purified	Cj0064c	15791456	flhF	flagellar biosynthesis regulator FlhF [C...	484	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1ZU4	17.4%	Campylobacter jejuni	Cell envelope	Surface structures

IDP04487 (show subtarget assignments)	1	expressed	YPO3598	115349219		putative membrane protein [Yersinia pest...	255	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP02469 (show subtarget assignments)	1	cloned	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02471 (show subtarget assignments)	1	cloned	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP04566 (show subtarget assignments)	1	expressed	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01658 (show subtarget assignments)	1	purified	Cj0059c	15791451	fliY	flagellar motor switch protein FliY [Cam...	280	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1O6A	15.4%	Campylobacter jejuni	Cell envelope	Other

IDP01656 (show subtarget assignments)	1	in_pdb 3OT5	lmo2537	16804575		hypothetical protein lmo2537 [Listeria m...	379	Known Essential Genes; PMID:16952950	Phase 3: June 2008	3OT5	100%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02009 (show subtarget assignments)	1	soluble	STM2925	16766231	nlpD	lipoprotein NlpD [Salmonella typhimurium...	377	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1QWY	23.3%	Salmonella enterica	Cell envelope	Other

IDP02464 (show subtarget assignments)	1	cloned	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP02468 (show subtarget assignments)	1	cloned	Cj0914c	15792243		invasion antigen B [Campylobacter jejuni...	610	Known Predicted virulence-invasion; PMID:10339609	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP02780 (show subtarget assignments)	1	soluble	GBAA0507	47525777		NAD-dependent epimerase/dehydratase fami...	321	Conserved; Drug target functions	Phase 3: June 2008	2B69	35.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01648 (show subtarget assignments)	1	cloned	YPO2944	16123127		putative pili chaperone protein [Yersini...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.8%	Yersinia pestis	Cell envelope	Surface structures

IDP02225 (show subtarget assignments)	1	cloned	CBU_1338	29541903		D-alanine--D-alanine ligase [Coxiella bu...	372	Conserved; Drug target functions	Phase 3: June 2008	3TQT	100%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00178 (show subtarget assignments)	1	soluble	YPO3405	16123554	-	putative ABC transporter, integral membr...	256	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02154 (show subtarget assignments)	1	expressed	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00802 (show subtarget assignments)	1	cloned	SACOL1704	57284716	mreC	rod shape-determining protein MreC	280	Conserved Gene / Pathway	Phase 2: March 2008	2J5U	29.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04480 (show subtarget assignments)	1	selected	YPO3104	218930142	wbyK	putative mannosyltransferase [Yersinia p...	337	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	2BIS	25.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01642 (show subtarget assignments)	1	cloned	Cj1150c	15792474	waaE	D,D-heptose 1-phosphate adenosyltransfer...	461	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	2AWD	15.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00022 (show subtarget assignments)	1	cloned	BA_5578	81714842		UDP-N-acetylglucosamine 1-carboxyvinyltr...	429	Drug Target Homolog	Phase 1: October 2007	3SG1	49.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02586 (show subtarget assignments)	1	cloned	Cj1478c	15792793	cadF	fibronectin-binding protein [Campylobact...	319	Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...	Phase 3: June 2008	3NB3	24.5%	Campylobacter jejuni	Cell envelope	Other

IDP01633 (show subtarget assignments)	1	soluble	FTT1569c	56708595	lpxA	UDP-N-acetylglucosamine acyltransferase ...	259	Conserved; Drug target functions	Phase 3: June 2008	1LXA	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01632 (show subtarget assignments)	1	cloned	FTT1571c	56708597	lpxD	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	337	Drug Target	Phase 3: June 2008	3EH0	45.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04460 (show subtarget assignments)	1	expressed	YPO1482	115347233		putative membrane protein [Yersinia pest...	1140	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP00794 (show subtarget assignments)	1	cloned	SACOL1194	57284479	pbp1	penicillin-binding protein 1	744	Drug Target Function	Phase 2: March 2008	1PYY	30.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00177 (show subtarget assignments)	1	purified	YPO3007	16123186	-	putative membrane protein	509	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02444 (show subtarget assignments)	1	cloned	YPO2224	16122453		hypothetical protein YPO2224 [Yersinia p...	103	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP00427 (show subtarget assignments)	1	in_pdb 3FWW	YPO4119	16124227	glmU	bifunctional N-acetylglucosamine-1-phosp...	456	Drug Target Function	Phase 2: March 2008	3FWW	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04447 (show subtarget assignments)	1	expressed	YPO0690	218927881		putative type II secretion protein [Yers...	428	putative drug target function;	Phase 4: April 2009	2OAP	26.6%	Yersinia pestis	Cell envelope	Surface structures

IDP00788 (show subtarget assignments)	1	purified	SACOL1043	57284414		glycosyl transferase, group 1 family pro...	493	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	16.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00425 (show subtarget assignments)	1	purified	YPO3863	16123998	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	420	Conserved Gene / Pathway	Phase 2: March 2008	3OJL	42.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02441 (show subtarget assignments)	1	purified	FTT1478c	56708518	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	Drug Target	Phase 3: June 2008	3TQD	51.2%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04441 (show subtarget assignments)	1	purified	YPO0321	115346137	alr	alanine racemase (biosynthetic) [Yersini...	359	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2RJG	71.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00780 (show subtarget assignments)	1	expressed	SACOL0694	57285664		tagH protein, teichoic acid ABC transpor...	264	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	23.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00777 (show subtarget assignments)	1	purified	SACOL0665	57284261		iron compound ABC transporter, iron comp...	295	Conserved Gene / Pathway	Phase 2: March 2008	3EIW	27.5%	Staphylococcus aureus	Cell envelope	Other

IDP00776 (show subtarget assignments)	1	crystallized	SACOL0612	57285627		glycosyl transferase, group 1 family pro...	496	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	11.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00775 (show subtarget assignments)	1	soluble	SACOL0611	57285626		glycosyl transferase, group 1 family pro...	490	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	14.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04412 (show subtarget assignments)	1	cloned	CPF_0435	110799959		putative lipoprotein [Clostridium perfri...	431	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01990 (show subtarget assignments)	0	work_stopped	Cj1435c	15792753		hypothetical protein Cj1435c [Campylobac...	211	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3FVV	26.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01513 (show subtarget assignments)	1	purified	VC1312	161582006	alr	alanine racemase	407	Conserved Gene / Pathway	Phase 2: March 2008	1BD0	25.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01994 (show subtarget assignments)	1	cloned	lmo1290	16803330		hypothetical protein lmo1290 [Listeria m...	598	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3BZ5	16.4%	Listeria monocytogenes	Cell envelope	Other

IDP04712 (show subtarget assignments)	1	cloned	YPO0514	115346324		putative OmpA-family membrane protein [Y...	536	virulence factor; putative drug target function;	Phase 4: April 2009	2L26	9%	Yersinia pestis	Cell envelope	Other

IDP00417 (show subtarget assignments)	1	cloned	YPO2604	16122817	pbpA	penicillin-binding protein 2	631	Drug Target Function	Phase 2: March 2008	3OC2	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04392 (show subtarget assignments)	1	cloned	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01982 (show subtarget assignments)	1	purified	FTT0975	56708067		hypothetical protein FTT0975 [Francisell...	229	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP00820 (show subtarget assignments)	1	purified	SACOL2167	57286380		iron compound ABC transporter, iron comp...	327	Conserved Gene / Pathway	Phase 2: March 2008	3EIW	89%	Staphylococcus aureus	Cell envelope	Other

IDP02010 (show subtarget assignments)	1	soluble	lmo1829	16803869		hypothetical protein lmo1829 [Listeria m...	570	Known virulence-adherence; PMID:15228540	Phase 3: June 2008	3DOA	21.1%	Listeria monocytogenes	Cell envelope	Surface structures

IDP01983 (show subtarget assignments)	0	work_stopped	Cj1437c	15792755		putative aminotransferase [Campylobacter...	367	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3GET	28.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01499 (show subtarget assignments)	1	cloned	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00758 (show subtarget assignments)	1	soluble	SACOL0140	57285343	cap5E	capsular polysaccharide biosynthesis pro...	342	Conserved Gene / Pathway	Phase 2: March 2008	2GN4	38%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02428 (show subtarget assignments)	1	expressed	GBAA3580	47528865		O-acetyltransferase, putative [Bacillus ...	188	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3VBI	99.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00756 (show subtarget assignments)	1	soluble	SACOL0115	57286664		glycosyl transferase, group 1 family pro...	388	Conserved Gene / Pathway	Phase 2: March 2008	3C48	21.8%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01494 (show subtarget assignments)	1	soluble	VCA0780	15601535		UDP-glucose 6-dehydrogenase	388	Conserved Gene / Pathway	Phase 2: March 2008	3PHL	71.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00822 (show subtarget assignments)	1	purified	SACOL2253	57285032	femX	femX protein	421	Conserved Gene / Pathway	Phase 2: March 2008	1LRZ	26.7%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01682 (show subtarget assignments)	1	cloned	GBAA5104	47530405		D-alanyl-D-alanine carboxypeptidase fami...	286	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02633 (show subtarget assignments)	1	cloned	Cj1431c	15792749		hypothetical protein Cj1431c [Campylobac...	582	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00021 (show subtarget assignments)	1	in_pdb 3SG1	BA_5529	81714862		UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Homolog	Phase 1: October 2007	3SG1	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00755 (show subtarget assignments)	1	cloned	SACOL0099	57286648	sirA	iron compound ABC transporter, iron comp...	330	Conserved Gene / Pathway	Phase 2: March 2008	3MWF	89.1%	Staphylococcus aureus	Cell envelope	Other

IDP00828 (show subtarget assignments)	1	expressed	SACOL2508	57285193	galU	UTP-glucose-1-phosphate uridylyltransfer...	288	Conserved Gene / Pathway	Phase 2: March 2008	2UX8	51.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01972 (show subtarget assignments)	1	cloned	CBU_0841	29541435		glycosyl transferase, group 1 family pro...	377	Conserved; Drug target functions	Phase 3: June 2008	2GEJ	24.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00413 (show subtarget assignments)	1	soluble	YPCD1.60	16082748	yscK	type III secretion apparatus component	209	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00753 (show subtarget assignments)	1	cloned	SACOL0052	57286607		glycosyl transferase, group 1 family pro...	503	Conserved Gene / Pathway	Phase 2: March 2008	2F9F	9.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01488 (show subtarget assignments)	1	purified	VCA0572	15601331	ddl	D-alanyl-alanine synthetase A	334	Conserved Gene / Pathway	Phase 2: March 2008	2FB9	34.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04356 (show subtarget assignments)	1	cloned	YPO0509	115346318		hypothetical protein [Yersinia pestis CO...	540	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2XT4	9.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01487 (show subtarget assignments)	1	soluble	VCA0270	15601038		D-alanyl-D-alanine carboxypeptidase	389	Drug Target Function	Phase 2: March 2008	1NZO	44.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04354 (show subtarget assignments)	1	expressed	YPCD1.44	5832464	YPCD1.44	putative Yop secretion membrane protein ...	217	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Surface structures

IDP01969 (show subtarget assignments)	1	cloned	Cj1441c	15792759	kfiD	putative UDP-glucose 6-dehydrogenase [Ca...	393	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3PHL	49.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02149 (show subtarget assignments)	1	cloned	Cj1428c	15792746	fcl	putative fucose synthetase [Campylobacte...	346	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1BSV	38.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01744 (show subtarget assignments)	1	expressed	STM2516	16765836	sinI	putative outer membrane protein [Salmone...	319	Essential; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cell envelope	Other

IDP01966 (show subtarget assignments)	1	expressed	Cj1439c	15792757	glf	UDP-galactopyranose mutase [Campylobacte...	368	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1I8T	59.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04549 (show subtarget assignments)	1	cloned	CPF_0346	110800626		putative lioprotein [Clostridium perfrin...	184	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01477 (show subtarget assignments)	1	purified	VC2762	15642755	glmU	bifunctional N-acetylglucosamine-1-phosp...	453	Drug Target Function	Phase 2: March 2008	1HV9	67.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00020 (show subtarget assignments)	1	purified	BA_5315	47605857		UDP-N-acetylenolpyruvoylglucosamine redu...	305	Drug Target Homolog	Phase 1: October 2007	1HSK	59.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02411 (show subtarget assignments)	1	expressed	YPO3640	16123782		hypothetical protein YPO3640 [Yersinia p...	448	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP04332 (show subtarget assignments)	1	cloned	YPO2723	218929795		putative OmpA family protein [Yersinia p...	261	virulence factor; putative drug target function;	Phase 4: April 2009	2ZOV	18%	Yersinia pestis	Cell envelope	Other

IDP01472 (show subtarget assignments)	1	cloned	VC2631	15642626		fimbrial assembly protein PilP, putative...	172	Conserved Gene / Pathway	Phase 2: March 2008	2LC4	16.3%	Vibrio cholerae	Cell envelope	Surface structures

IDP04329 (show subtarget assignments)	1	expressed	CPF_1466	110801108		putative lipoprotein [Clostridium perfri...	483	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02410 (show subtarget assignments)	1	purified	Cj1328	15792651	neuC2	putative N-acetylglucosamine-6-phosphate...	384	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3BEO	20.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01466 (show subtarget assignments)	1	purified	VC2542	15642537		UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	451	Conserved Gene / Pathway	Phase 2: March 2008	3HN7	51%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00082 (show subtarget assignments)	0	work_stopped	NTL01ST4427	16423142	lplA	lipoate-protein ligase A	338		Phase 1: October 2007	1X2G	93.2%	Salmonella enterica	Cell envelope	Other

IDP01463 (show subtarget assignments)	1	purified	VC2514	15642510		UDP-N-acetylglucosamine 1-carboxyvinyltr...	419	Drug Target Function	Phase 2: March 2008	1NAW	80.9%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02767 (show subtarget assignments)	1	cloned	GBAA4750	47530050		D-alanyl-D-alanine carboxypeptidase fami...	259	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00406 (show subtarget assignments)	1	cloned	YPO3410	16123559		hypothetical protein YPO3410	115	Virulence Associated Factor	Phase 2: March 2008	3UTK	26.1%	Yersinia pestis	Cell envelope	Other

IDP01460 (show subtarget assignments)	1	cloned	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP01457 (show subtarget assignments)	1	cloned	VC2407	15642404		penicillin-binding protein 3	580	Drug Target Function	Phase 2: March 2008	3OC2	41.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456 (show subtarget assignments)	1	purified	VC2406	15642403	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	512	Conserved Gene / Pathway	Phase 2: March 2008	1E8C	50.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04317 (show subtarget assignments)	1	cloned	YPO0512	218927711		putative lipoprotein [Yersinia pestis CO...	163	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP01455 (show subtarget assignments)	1	purified	VC2405	15642402		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	453	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	52.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01454 (show subtarget assignments)	1	purified	VC2403	161581989	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	444	Conserved Gene / Pathway	Phase 2: March 2008	1E0D	51.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453 (show subtarget assignments)	1	cloned	VC2401	15642398	murG	N-acetylglucosaminyl transferase	354	Conserved Gene / Pathway	Phase 2: March 2008	1F0K	63.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01452 (show subtarget assignments)	1	soluble	VC2400	15642397	murC	UDP-N-acetylmuramate--L-alanine ligase	506	Conserved Gene / Pathway	Phase 2: March 2008	2F00	69.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01449 (show subtarget assignments)	1	purified	VC2248	15642246		UDP-N-acetylglucosamine acyltransferase ...	262	Drug Target Function	Phase 2: March 2008	1LXA	68.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01448 (show subtarget assignments)	1	cloned	VC2213	15642211		outer membrane protein OmpA	321	Conserved Gene / Pathway	Phase 2: March 2008	3NB3	34.7%	Vibrio cholerae	Cell envelope	Other

IDP00403 (show subtarget assignments)	1	soluble	YPO1125	16121425	pal	peptidoglycan-associated outer membrane ...	168	Conserved Gene / Pathway	Phase 2: March 2008	1OAP	58.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02035 (show subtarget assignments)	1	cloned	Cj1141	15792466	neuB1	N-acetylneuraminic acid synthetase [Camp...	343	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1XUU	59%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01447 (show subtarget assignments)	1	purified	VC2181	15642180	lolB	outer membrane lipoprotein LolB	211	Conserved Gene / Pathway	Phase 2: March 2008	1IWM	30.3%	Vibrio cholerae	Cell envelope	Other

IDP00080 (show subtarget assignments)	1	expressed	NT01ST5073	16422645	yneC	putative inner membrane protein	109	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3QMQ	70.6%	Salmonella enterica	Cell envelope	Other

IDP01952 (show subtarget assignments)	1	cloned	Cj1432c	15792750		putative sugar transferase [Campylobacte...	1031	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2IV7	7.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02627 (show subtarget assignments)	1	soluble	Cj1729c	15793032	flgE	flagellar hook protein FlgE [Campylobact...	865	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	13.4%	Campylobacter jejuni	Cell envelope	Other

IDP01442 (show subtarget assignments)	1	expressed	VC2048	15642050		vacJ lipoprotein	254	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP02590 (show subtarget assignments)	1	soluble	FTT0831c	56707940		OmpA family protein [Francisella tularen...	417	Drug Target	Phase 3: June 2008	2K1S	11%	Francisella tularensis	Cell envelope	Other

IDP01664
(show subtarget assignments)

1

purified

Cj0064c

15791456

flhF

flagellar biosynthesis regulator FlhF [C...

484

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1ZU4

17.4%

Campylobacter jejuni

Cell envelope

Surface structures

IDP04487
(show subtarget assignments)

1

expressed

YPO3598

115349219

putative membrane protein [Yersinia pest...

255

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP02469
(show subtarget assignments)

1

cloned

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02471
(show subtarget assignments)

1

cloned

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP04566
(show subtarget assignments)

1

expressed

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01658
(show subtarget assignments)

1

purified

Cj0059c

15791451

fliY

flagellar motor switch protein FliY [Cam...

280

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1O6A

15.4%

Campylobacter jejuni

Cell envelope

Other

IDP01656
(show subtarget assignments)

1

in_pdb
3OT5

lmo2537

16804575

hypothetical protein lmo2537 [Listeria m...

379

Known Essential Genes; PMID:16952950

Phase 3: June 2008

3OT5

100%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02009
(show subtarget assignments)

1

soluble

STM2925

16766231

nlpD

lipoprotein NlpD [Salmonella typhimurium...

377

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1QWY

23.3%

Salmonella enterica

Cell envelope

Other

IDP02464
(show subtarget assignments)

1

cloned

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP02468
(show subtarget assignments)

1

cloned

Cj0914c

15792243

invasion antigen B [Campylobacter jejuni...

610

Known Predicted virulence-invasion; PMID:10339609

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP02780
(show subtarget assignments)

1

soluble

GBAA0507

47525777

NAD-dependent epimerase/dehydratase fami...

321

Conserved; Drug target functions

Phase 3: June 2008

2B69

35.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01648
(show subtarget assignments)

1

cloned

YPO2944

16123127

putative pili chaperone protein [Yersini...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.8%

Yersinia pestis

Cell envelope

Surface structures

IDP02225
(show subtarget assignments)

1

cloned

CBU_1338

29541903

D-alanine--D-alanine ligase [Coxiella bu...

372

Conserved; Drug target functions

Phase 3: June 2008

3TQT

100%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00178
(show subtarget assignments)

1

soluble

YPO3405

16123554

-

putative ABC transporter, integral membr...

256

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02154
(show subtarget assignments)

1

expressed

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00802
(show subtarget assignments)

1

cloned

SACOL1704

57284716

mreC

rod shape-determining protein MreC

280

Conserved Gene / Pathway

Phase 2: March 2008

2J5U

29.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04480
(show subtarget assignments)

1

selected

YPO3104

218930142

wbyK

putative mannosyltransferase [Yersinia p...

337

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

2BIS

25.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01642
(show subtarget assignments)

1

cloned

Cj1150c

15792474

waaE

D,D-heptose 1-phosphate adenosyltransfer...

461

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

2AWD

15.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00022
(show subtarget assignments)

1

cloned

BA_5578

81714842

UDP-N-acetylglucosamine 1-carboxyvinyltr...

429

Drug Target Homolog

Phase 1: October 2007

3SG1

49.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02586
(show subtarget assignments)

1

cloned

Cj1478c

15792793

cadF

fibronectin-binding protein [Campylobact...

319

Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...

Phase 3: June 2008

3NB3

24.5%

Campylobacter jejuni

Cell envelope

Other

IDP01633
(show subtarget assignments)

1

soluble

FTT1569c

56708595

lpxA

UDP-N-acetylglucosamine acyltransferase ...

259

Conserved; Drug target functions

Phase 3: June 2008

1LXA

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01632
(show subtarget assignments)

1

cloned

FTT1571c

56708597

lpxD

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

337

Drug Target

Phase 3: June 2008

3EH0

45.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04460
(show subtarget assignments)

1

expressed

YPO1482

115347233

putative membrane protein [Yersinia pest...

1140

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP00794
(show subtarget assignments)

1

cloned

SACOL1194

57284479

pbp1

penicillin-binding protein 1

744

Drug Target Function

Phase 2: March 2008

1PYY

30.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00177
(show subtarget assignments)

1

purified

YPO3007

16123186

-

putative membrane protein

509

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02444
(show subtarget assignments)

1

cloned

YPO2224

16122453

hypothetical protein YPO2224 [Yersinia p...

103

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP00427
(show subtarget assignments)

1

in_pdb
3FWW

YPO4119

16124227

glmU

bifunctional N-acetylglucosamine-1-phosp...

456

Drug Target Function

Phase 2: March 2008

3FWW

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04447
(show subtarget assignments)

1

expressed

YPO0690

218927881

putative type II secretion protein [Yers...

428

putative drug target function;

Phase 4: April 2009

2OAP

26.6%

Yersinia pestis

Cell envelope

Surface structures

IDP00788
(show subtarget assignments)

1

purified

SACOL1043

57284414

glycosyl transferase, group 1 family pro...

493

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

16.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00425
(show subtarget assignments)

1

purified

YPO3863

16123998

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

420

Conserved Gene / Pathway

Phase 2: March 2008

3OJL

42.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02441
(show subtarget assignments)

1

purified

FTT1478c

56708518

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

Drug Target

Phase 3: June 2008

3TQD

51.2%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04441
(show subtarget assignments)

1

purified

YPO0321

115346137

alr

alanine racemase (biosynthetic) [Yersini...

359

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2RJG

71.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00780
(show subtarget assignments)

1

expressed

SACOL0694

57285664

tagH protein, teichoic acid ABC transpor...

264

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

23.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00777
(show subtarget assignments)

1

purified

SACOL0665

57284261

iron compound ABC transporter, iron comp...

295

Conserved Gene / Pathway

Phase 2: March 2008

3EIW

27.5%

Staphylococcus aureus

Cell envelope

Other

IDP00776
(show subtarget assignments)

1

crystallized

SACOL0612

57285627

glycosyl transferase, group 1 family pro...

496

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

11.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00775
(show subtarget assignments)

1

soluble

SACOL0611

57285626

glycosyl transferase, group 1 family pro...

490

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

14.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04412
(show subtarget assignments)

1

cloned

CPF_0435

110799959

putative lipoprotein [Clostridium perfri...

431

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01990
(show subtarget assignments)

0

work_stopped

Cj1435c

15792753

hypothetical protein Cj1435c [Campylobac...

211

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3FVV

26.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01513
(show subtarget assignments)

1

purified

VC1312

161582006

alr

alanine racemase

407

Conserved Gene / Pathway

Phase 2: March 2008

1BD0

25.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01994
(show subtarget assignments)

1

cloned

lmo1290

16803330

hypothetical protein lmo1290 [Listeria m...

598

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3BZ5

16.4%

Listeria monocytogenes

Cell envelope

Other

IDP04712
(show subtarget assignments)

1

cloned

YPO0514

115346324

putative OmpA-family membrane protein [Y...

536

virulence factor; putative drug target function;

Phase 4: April 2009

2L26

9%

Yersinia pestis

Cell envelope

Other

IDP00417
(show subtarget assignments)

1

cloned

YPO2604

16122817

pbpA

penicillin-binding protein 2

631

Drug Target Function

Phase 2: March 2008

3OC2

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04392
(show subtarget assignments)

1

cloned

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01982
(show subtarget assignments)

1

purified

FTT0975

56708067

hypothetical protein FTT0975 [Francisell...

229

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP00820
(show subtarget assignments)

1

purified

SACOL2167

57286380

iron compound ABC transporter, iron comp...

327

Conserved Gene / Pathway

Phase 2: March 2008

3EIW

89%

Staphylococcus aureus

Cell envelope

Other

IDP02010
(show subtarget assignments)

1

soluble

lmo1829

16803869

hypothetical protein lmo1829 [Listeria m...

570

Known virulence-adherence; PMID:15228540

Phase 3: June 2008

3DOA

21.1%

Listeria monocytogenes

Cell envelope

Surface structures

IDP01983
(show subtarget assignments)

0

work_stopped

Cj1437c

15792755

putative aminotransferase [Campylobacter...

367

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3GET

28.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01499
(show subtarget assignments)

1

cloned

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00758
(show subtarget assignments)

1

soluble

SACOL0140

57285343

cap5E

capsular polysaccharide biosynthesis pro...

342

Conserved Gene / Pathway

Phase 2: March 2008

2GN4

38%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02428
(show subtarget assignments)

1

expressed

GBAA3580

47528865

O-acetyltransferase, putative [Bacillus ...

188

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3VBI

99.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00756
(show subtarget assignments)

1

soluble

SACOL0115

57286664

glycosyl transferase, group 1 family pro...

388

Conserved Gene / Pathway

Phase 2: March 2008

3C48

21.8%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01494
(show subtarget assignments)

1

soluble

VCA0780

15601535

UDP-glucose 6-dehydrogenase

388

Conserved Gene / Pathway

Phase 2: March 2008

3PHL

71.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00822
(show subtarget assignments)

1

purified

SACOL2253

57285032

femX

femX protein

421

Conserved Gene / Pathway

Phase 2: March 2008

1LRZ

26.7%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01682
(show subtarget assignments)

1

cloned

GBAA5104

47530405

D-alanyl-D-alanine carboxypeptidase fami...

286

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02633
(show subtarget assignments)

1

cloned

Cj1431c

15792749

hypothetical protein Cj1431c [Campylobac...

582

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00021
(show subtarget assignments)

1

in_pdb
3SG1

BA_5529

81714862

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Homolog

Phase 1: October 2007

3SG1

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00755
(show subtarget assignments)

1

cloned

SACOL0099

57286648

sirA

iron compound ABC transporter, iron comp...

330

Conserved Gene / Pathway

Phase 2: March 2008

3MWF

89.1%

Staphylococcus aureus

Cell envelope

Other

IDP00828
(show subtarget assignments)

1

expressed

SACOL2508

57285193

galU

UTP-glucose-1-phosphate uridylyltransfer...

288

Conserved Gene / Pathway

Phase 2: March 2008

2UX8

51.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01972
(show subtarget assignments)

1

cloned

CBU_0841

29541435

glycosyl transferase, group 1 family pro...

377

Conserved; Drug target functions

Phase 3: June 2008

2GEJ

24.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00413
(show subtarget assignments)

1

soluble

YPCD1.60

16082748

yscK

type III secretion apparatus component

209

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00753
(show subtarget assignments)

1

cloned

SACOL0052

57286607

glycosyl transferase, group 1 family pro...

503

Conserved Gene / Pathway

Phase 2: March 2008

2F9F

9.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01488
(show subtarget assignments)

1

purified

VCA0572

15601331

ddl

D-alanyl-alanine synthetase A

334

Conserved Gene / Pathway

Phase 2: March 2008

2FB9

34.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04356
(show subtarget assignments)

1

cloned

YPO0509

115346318

hypothetical protein [Yersinia pestis CO...

540

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2XT4

9.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01487
(show subtarget assignments)

1

soluble

VCA0270

15601038

D-alanyl-D-alanine carboxypeptidase

389

Drug Target Function

Phase 2: March 2008

1NZO

44.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04354
(show subtarget assignments)

1

expressed

YPCD1.44

5832464

YPCD1.44

putative Yop secretion membrane protein ...

217

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Surface structures

IDP01969
(show subtarget assignments)

1

cloned

Cj1441c

15792759

kfiD

putative UDP-glucose 6-dehydrogenase [Ca...

393

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3PHL

49.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02149
(show subtarget assignments)

1

cloned

Cj1428c

15792746

fcl

putative fucose synthetase [Campylobacte...

346

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1BSV

38.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01744
(show subtarget assignments)

1

expressed

STM2516

16765836

sinI

putative outer membrane protein [Salmone...

319

Essential; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cell envelope

Other

IDP01966
(show subtarget assignments)

1

expressed

Cj1439c

15792757

glf

UDP-galactopyranose mutase [Campylobacte...

368

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1I8T

59.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04549
(show subtarget assignments)

1

cloned

CPF_0346

110800626

putative lioprotein [Clostridium perfrin...

184

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01477
(show subtarget assignments)

1

purified

VC2762

15642755

glmU

bifunctional N-acetylglucosamine-1-phosp...

453

Drug Target Function

Phase 2: March 2008

1HV9

67.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00020
(show subtarget assignments)

1

purified

BA_5315

47605857

UDP-N-acetylenolpyruvoylglucosamine redu...

305

Drug Target Homolog

Phase 1: October 2007

1HSK

59.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02411
(show subtarget assignments)

1

expressed

YPO3640

16123782

hypothetical protein YPO3640 [Yersinia p...

448

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP04332
(show subtarget assignments)

1

cloned

YPO2723

218929795

putative OmpA family protein [Yersinia p...

261

virulence factor; putative drug target function;

Phase 4: April 2009

2ZOV

18%

Yersinia pestis

Cell envelope

Other

IDP01472
(show subtarget assignments)

1

cloned

VC2631

15642626

fimbrial assembly protein PilP, putative...

172

Conserved Gene / Pathway

Phase 2: March 2008

2LC4

16.3%

Vibrio cholerae

Cell envelope

Surface structures

IDP04329
(show subtarget assignments)

1

expressed

CPF_1466

110801108

putative lipoprotein [Clostridium perfri...

483

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02410
(show subtarget assignments)

1

purified

Cj1328

15792651

neuC2

putative N-acetylglucosamine-6-phosphate...

384

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3BEO

20.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01466
(show subtarget assignments)

1

purified

VC2542

15642537

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

451

Conserved Gene / Pathway

Phase 2: March 2008

3HN7

51%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00082
(show subtarget assignments)

0

work_stopped

NTL01ST4427

16423142

lplA

lipoate-protein ligase A

338

Phase 1: October 2007

1X2G

93.2%

Salmonella enterica

Cell envelope

Other

IDP01463
(show subtarget assignments)

1

purified

VC2514

15642510

UDP-N-acetylglucosamine 1-carboxyvinyltr...

419

Drug Target Function

Phase 2: March 2008

1NAW

80.9%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02767
(show subtarget assignments)

1

cloned

GBAA4750

47530050

D-alanyl-D-alanine carboxypeptidase fami...

259

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00406
(show subtarget assignments)

1

cloned

YPO3410

16123559

hypothetical protein YPO3410

115

Virulence Associated Factor

Phase 2: March 2008

3UTK

26.1%

Yersinia pestis

Cell envelope

Other

IDP01460
(show subtarget assignments)

1

cloned

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP01457
(show subtarget assignments)

1

cloned

VC2407

15642404

penicillin-binding protein 3

580

Drug Target Function

Phase 2: March 2008

3OC2

41.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456
(show subtarget assignments)

1

purified

VC2406

15642403

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

512

Conserved Gene / Pathway

Phase 2: March 2008

1E8C

50.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04317
(show subtarget assignments)

1

cloned

YPO0512

218927711

putative lipoprotein [Yersinia pestis CO...

163

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP01455
(show subtarget assignments)

1

purified

VC2405

15642402

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

453

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

52.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01454
(show subtarget assignments)

1

purified

VC2403

161581989

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

444

Conserved Gene / Pathway

Phase 2: March 2008

1E0D

51.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453
(show subtarget assignments)

1

cloned

VC2401

15642398

murG

N-acetylglucosaminyl transferase

354

Conserved Gene / Pathway

Phase 2: March 2008

1F0K

63.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01452
(show subtarget assignments)

1

soluble

VC2400

15642397

murC

UDP-N-acetylmuramate--L-alanine ligase

506

Conserved Gene / Pathway

Phase 2: March 2008

2F00

69.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01449
(show subtarget assignments)

1

purified

VC2248

15642246

UDP-N-acetylglucosamine acyltransferase ...

262

Drug Target Function

Phase 2: March 2008

1LXA

68.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01448
(show subtarget assignments)

1

cloned

VC2213

15642211

outer membrane protein OmpA

321

Conserved Gene / Pathway

Phase 2: March 2008

3NB3

34.7%

Vibrio cholerae

Cell envelope

Other

IDP00403
(show subtarget assignments)

1

soluble

YPO1125

16121425

pal

peptidoglycan-associated outer membrane ...

168

Conserved Gene / Pathway

Phase 2: March 2008

1OAP

58.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02035
(show subtarget assignments)

1

cloned

Cj1141

15792466

neuB1

N-acetylneuraminic acid synthetase [Camp...

343

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1XUU

59%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01447
(show subtarget assignments)

1

purified

VC2181

15642180

lolB

outer membrane lipoprotein LolB

211

Conserved Gene / Pathway

Phase 2: March 2008

1IWM

30.3%

Vibrio cholerae

Cell envelope

Other

IDP00080
(show subtarget assignments)

1

expressed

NT01ST5073

16422645

yneC

putative inner membrane protein

109

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3QMQ

70.6%

Salmonella enterica

Cell envelope

Other

IDP01952
(show subtarget assignments)

1

cloned

Cj1432c

15792750

putative sugar transferase [Campylobacte...

1031

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2IV7

7.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02627
(show subtarget assignments)

1

soluble

Cj1729c

15793032

flgE

flagellar hook protein FlgE [Campylobact...

865

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

13.4%

Campylobacter jejuni

Cell envelope

Other

IDP01442
(show subtarget assignments)

1

expressed

VC2048

15642050

vacJ lipoprotein

254

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP02590
(show subtarget assignments)

1

soluble

FTT0831c

56707940

OmpA family protein [Francisella tularen...

417

Drug Target

Phase 3: June 2008

2K1S

11%

Francisella tularensis

Cell envelope

Other

Targets