Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00836 (show subtarget assignments)	1	in_pdb 3GIU	SACOL2714	57285268	pcp	pyrrolidone-carboxylate peptidase	212	Drug Target Function	Phase 2: March 2008	3GIU	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01467 (show subtarget assignments)	1	purified	VC2549	15642544		methionine sulfoxide reductase A	212	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	56.1%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP04477 (show subtarget assignments)	1	soluble	YPO2829	115348505	purN	putative phosphoribosylglycinamide formy...	212	conserved gene; putative drug target function;	Phase 4: April 2009	2GAR	71.7%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90794 (show subtarget assignments)	8	soluble	Cj0763c	15792101	cysE	serine acetyltransferase [Campylobacter ...	212	Predicted Essential	Community Requests	3P1B	34.9%	Campylobacter jejuni

IDP00932 (show subtarget assignments)	1	purified	STM0645	16764022	nadD	nicotinic acid mononucleotide adenyltran...	213	Conserved Gene / Pathway	Phase 2: March 2008	1K4K	85.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP91573 (show subtarget assignments)	8	soluble	BAB35577	13361620	ECs2154	hypothetical protein [Escherichia coli O...	213	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	19.7%	Escherichia coli

IDP91572 (show subtarget assignments)	8	soluble	BAB35419	13361461	ECs1996	hypothetical protein [Escherichia coli O...	213	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	20.2%	Escherichia coli

IDP05211 (show subtarget assignments)	1	cloned	CD2574	126700193		putative thiamine pyrophosphokinase [Clo...	213	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3IHK	28.8%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00716 (show subtarget assignments)	1	purified	SACOL1420	57286071		phosphate transport system protein PhoU,...	213	Conserved Gene / Pathway	Phase 2: March 2008	1T72	31%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP00036 (show subtarget assignments)	1	purified	BA_1840	30256110		fibronectin-binding protein, putative	213	Virulence	Phase 1: October 2007	2YB5	32.9%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP05440 (show subtarget assignments)	1	soluble	BA_3272	30257827		hypothetical protein BA_3272 [Bacillus a...	213	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP02032 (show subtarget assignments)	1	expressed	YPO0013	16120366	mobA	molybdopterin-guanine dinucleotide biosy...	213	Involved in virulence; Drug target functions	Phase 3: June 2008	1E5K	39.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP05534 (show subtarget assignments)	1	purified	CD3106	126700723		putative phopho-sugar aldolase [Clostrid...	213	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WX0	33.3%	Clostridium difficile	Unknown function: General

IDP90420 (show subtarget assignments)	8	cloned	CT_465	3328899		hypothetical protein [Chlamydia trachoma...	213	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04500 (show subtarget assignments)	1	purified	VC0986	15641001	adk	adenylate kinase [Vibrio cholerae O1 bio...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AKE	73.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP91820 (show subtarget assignments)	8	selected	b0474	1786680	adk	adenylate kinase [Escherichia coli str. ...	214	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1AKE	100%	Escherichia coli

IDP02752 (show subtarget assignments)	1	crystallized	FTT0650c	56707772	grxB	glutaredoxin 2 [Francisella tularensis s...	214	Drug Target	Phase 3: June 2008	3IR4	30.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP05053 (show subtarget assignments)	1	expressed	CD0242	126697813		hypothetical protein CD0242 [Clostridium...	214	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3D5N	18.7%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP90221 (show subtarget assignments)	8	cloned	MYXV_gp157	9633790	m154L	m154L, gp120-like	214	NFkB inhibitor, similar to VACV-Cop:M2L	Community Requests			Myxoma virus	host defense modulator	0

IDP00480 (show subtarget assignments)	1	soluble	YPO3118	16123283	adk	adenylate kinase	214	Conserved Gene / Pathway	Phase 2: March 2008	1AKE	87.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04642 (show subtarget assignments)	1	expressed	FTT0716	56707835	upp	uracil phosphoribosyltransferase [Franci...	214	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2EHJ	69.2%	Francisella tularensis

IDP00779 (show subtarget assignments)	1	soluble	SACOL0691	57285661	sirR	iron-dependent repressor	214	Conserved Gene / Pathway	Phase 2: March 2008	3HRS	37.4%	Staphylococcus aureus	Regulatory functions	DNA interactions

IDP01847 (show subtarget assignments)	1	soluble	GBAA5416	47530729	ftsE	cell division ABC transporter, ATP-bindi...	214	Conserved; Drug target functions	Phase 3: June 2008	3DHW	41.1%	Bacillus anthracis	Cellular processes	Cell division

IDP90785 (show subtarget assignments)	8	in_pdb 3N2L	VC0211	15640241	pyrE	orotate phosphoribosyltransferase [Vibri...	214	Predicted Essential	Community Requests	3N2L	100%	Vibrio cholerae

IDP02145 (show subtarget assignments)	1	cloned	YPO1301	16121583	psaE	putative regulatory protein [Yersinia pe...	214	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP05588 (show subtarget assignments)	1	cloned	BA_2883	30257480		putative lipoprotein [Bacillus anthracis...	214	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP90372 (show subtarget assignments)	8	expressed	CT_253	3328664		hypothetical protein [Chlamydia trachoma...	215	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02531 (show subtarget assignments)	1	in_pdb 3LAC	GBAA3090	50196941	pcP	pyrrolidone-carboxylate peptidase [Bacil...	215	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LAC	99.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04287 (show subtarget assignments)	1	cloned	YPO2703	115348386	pcp	putative pyrrolidone-carboxylate peptida...	215	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3LAC	54%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04700 (show subtarget assignments)	1	cloned	YPO0045	218927266	pyrE	orotate phosphoribosyltransferase [Yersi...	215	conserved gene; putative drug target function;	Phase 4: April 2009	1LH0	85.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90212 (show subtarget assignments)	8	cloned	MYXV_gp067	9633699	m063R	m063R, m63R	215	CD47-like	Community Requests			Myxoma virus	host range factor, host defense modulator	0

IDP05727 (show subtarget assignments)	1	cloned	BA_4605	30259105		conserved hypothetical protein [Bacillus...	215	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP00895 (show subtarget assignments)	1	in_pdb 3IR4	STM1165	16764521	grxB	glutaredoxin 2	215	Conserved Gene / Pathway	Phase 2: March 2008	3IR4	100%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP00887 (show subtarget assignments)	1	expressed	STM2349	16765676	yfcG	putative glutathione S-transferase	215	Conserved Gene / Pathway	Phase 2: March 2008	3GX0	80.5%	Salmonella enterica	Cellular processes	Detoxification

IDP01486 (show subtarget assignments)	1	in_pdb 3IEB 3JR2	VCA0242	15601010	ulaD	3-keto-L-gulonate-6-phosphate decarboxyl...	215	Conserved Gene / Pathway	Phase 2: March 2008	3IEB	100%	Vibrio cholerae	Energy metabolism	Sugars

IDP02052 (show subtarget assignments)	1	cloned	YPO2924	16123111		hypothetical protein YPO2924 [Yersinia p...	215	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP90710 (show subtarget assignments)	8	purified	Cj0451	15791815	rep	ribulose-phosphate 3-epimerase [Campylob...	215	Predicted Essential	Community Requests	1RPX	48.4%	Campylobacter jejuni

IDP00165 (show subtarget assignments)	1	cloned	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP91570 (show subtarget assignments)	8	expressed	BAB35247	13361289	ECs1824	hypothetical protein [Escherichia coli O...	215	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	17.7%	Escherichia coli

IDP00618 (show subtarget assignments)	1	soluble	SACOL2348	57285082		drug transporter, putative	215	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04119 (show subtarget assignments)	1	purified	BAS0131	49183165		adenylate kinase [Bacillus anthracis str...	216	Proposed to be essential proteins	Phase 4: April 2009	1ZIN	74.1%	Bacillus anthracis

IDP02448 (show subtarget assignments)	1	in_pdb 3KD3	FTT0568	56707697		hypothetical protein FTT0568 [Francisell...	216	Drug Target	Phase 3: June 2008	3KD3	100%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP04417 (show subtarget assignments)	1	purified	FTT0033	56707213	nuoC	NADH dehydrogenase I [Francisella tulare...	216	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2FUG	21.8%	Francisella tularensis

IDP05295 (show subtarget assignments)	1	cloned	CD1816	126699424	cmk	cytidylate kinase [Clostridium difficile...	216	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Q3T	44.4%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05316 (show subtarget assignments)	1	in_pdb 3SD7	CD3605	126701232		putative phosphatase [Clostridium diffic...	216	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3SD7	100%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions

IDP00508 (show subtarget assignments)	1	expressed	YPO1315	16121597		putative hydrolase	216	Conserved Gene / Pathway	Phase 2: March 2008	3FVV	35.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP04701 (show subtarget assignments)	1	expressed	YPO0270	115346088		putative type III secretion apparatus pr...	216	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cellular processes	Pathogenesis

IDP00194 (show subtarget assignments)	1	cloned	YPO0983	16121287	-	putative membrane protein	216	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP90853 (show subtarget assignments)	8	cloned	YPO0647	16120972		putative glycerol-3-phosphate acyltransf...	216	Predicted Essential	Community Requests			Yersinia pestis

IDP00041 (show subtarget assignments)	1	purified	BA_2409	30257040		chloramphenicol acetyltransferase	216	Virulence	Phase 1: October 2007	1QCA	41.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02630 (show subtarget assignments)	1	expressed	STM2899	16766205	invF	invasion regulatory protein [Salmonella ...	216	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP91502 (show subtarget assignments)	8	expressed	VP1672	28898446		type III secretion system protein [Vibri...	216	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP01376 (show subtarget assignments)	1	soluble	VC0400	15640427		MSHA biogenesis protein MshJ	216	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP91614 (show subtarget assignments)	8	purified	BAB36909	13362957	ECs3486	hypothetical protein [Escherichia coli O...	216	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	14.4%	Escherichia coli

IDP91817 (show subtarget assignments)	8	selected	b2217	1788546	rcsB	DNA-binding response regulator in two-co...	216	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1P4W	36.6%	Escherichia coli

IDP05429 (show subtarget assignments)	1	cloned	lmo0791	16802833	-	hypothetical protein lmo0791 [Listeria m...	216	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP90641 (show subtarget assignments)	8	purified	Cj0099	15791487	birA	biotin--protein ligase [Campylobacter je...	217	Predicted Essential	Community Requests	2EAY	27.2%	Campylobacter jejuni

IDP00578 (show subtarget assignments)	1	purified	YPO3553	16123697	elbB	isoprenoid biosynthesis protein with ami...	217	Drug Target Function	Phase 2: March 2008	1OY1	63.6%	Yersinia pestis	Unknown function	General

IDP04471 (show subtarget assignments)	1	purified	YPO2370	218929461	pdxH	pyridoxamine 5'-phosphate oxidase [Yersi...	217	conserved gene; putative drug target function;	Phase 4: April 2009	1G76	78.4%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02371 (show subtarget assignments)	1	expressed	CBU_1904	29542461	ftsE	cell division ABC transporter, ATP-bindi...	217	Conserved; Drug target functions	Phase 3: June 2008	1F3O	38.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02616 (show subtarget assignments)	1	in_pdb 3LHQ	STM0477	16763857	acrR	DNA-binding transcriptional repressor Ac...	217	Conserved; Drug target functions	Phase 3: June 2008	3LHQ	100%	Salmonella enterica	Transport and binding proteins	Other

IDP04062 (show subtarget assignments)	1	purified	VCA0637	9658051		oxygen-insensitive NAD(P)H nitroreductas...	217	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HZN	59.4%	Vibrio cholerae	Central intermediary metabolism	Other

IDP00923 (show subtarget assignments)	1	in_pdb 3HZN	STM0578	16763955	nfnB	dihydropteridine reductase	217	Conserved Gene / Pathway	Phase 2: March 2008	3HZN	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP01748 (show subtarget assignments)	1	soluble	PSLT011	17233476	srgA	putative thiol-disulfide isomerase or th...	217	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3L9V	85.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP00479 (show subtarget assignments)	1	in_pdb 3H07	YPO0658	16120983	ribB	3,4-dihydroxy-2-butanone 4-phosphate syn...	217	Conserved Gene / Pathway	Phase 2: March 2008	3H07	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90588 (show subtarget assignments)	8	cloned	Q9KLX5	23821639		RecName: Full=GTP cyclohydrolase 1; AltN...	217	Predicted Essential	Community Requests	1FBX	70.5%	Vibrio cholerae

IDP91802 (show subtarget assignments)	8	crystallized	lpg0123	52840378	dsbA	thiol:disulfide interchange protein DsbA...	217	virulence/pathogenesis / Legionella pneumophila is most closely related to Coxiella burnetti, the causati...	Community Requests	3L9S	27.6%	Legionella pneumophila

IDP04354 (show subtarget assignments)	1	expressed	YPCD1.44	5832464	YPCD1.44	putative Yop secretion membrane protein ...	217	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Surface structures

IDP90507 (show subtarget assignments)	8	soluble	VC2270	15642268		riboflavin synthase subunit alpha [Vibri...	217	Predicted Essential	Community Requests	1KZL	35.5%	Vibrio cholerae

IDP02769 (show subtarget assignments)	1	cloned	FTT0304c	56707457	nfnB	dihydropteridine reductase [Francisella ...	217	Drug Target	Phase 3: June 2008	3HZN	45.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP00850 (show subtarget assignments)	1	soluble	SACOL2389	57285120		transcriptional regulatory protein DegU,...	217	Conserved Gene / Pathway	Phase 2: March 2008	1A04	31.3%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP91409 (show subtarget assignments)	8	cloned	VV1_0717	27364172		hypothetical protein VV1_0717 [Vibrio vu...	217	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91615 (show subtarget assignments)	8	purified	BAB36137	13362182	ECs2714	hypothetical protein [Escherichia coli O...	217	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP91270 (show subtarget assignments)	8	selected	NT05BA3459	49180224		acetyltransf2, N-acetyltransferase [Baci...	217	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LNB	47.9%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP04037 (show subtarget assignments)	1	in_pdb 3S52	YPO2082	115347800		putative fumarylacetoacetate hydrolase f...	218	putative drug target function;	Phase 4: April 2009	3S52	100%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00529 (show subtarget assignments)	1	expressed	YPO2734	16122938	ccmA	putative heme exporter protein A	218	Virulence Associated Factor	Phase 2: March 2008	1B0U	27.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90938 (show subtarget assignments)	8	cloned	NMPDR 243277.1.peg.3917				218	Predicted Essential	Community Requests	2JGV	22.5%	Vibrio cholerae

IDP05582 (show subtarget assignments)	1	cloned	BA_1978	30256633		putative lipoprotein [Bacillus anthracis...	218	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP01798 (show subtarget assignments)	1	cloned	GBAA1130	47526400		S-layer protein, putative [Bacillus anth...	218	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.2%	Bacillus anthracis	Cell envelope	Surface structures

IDP04105 (show subtarget assignments)	1	purified	YPO2391	115348093	ribC	riboflavin synthase alpha chain [Yersini...	218	conserved gene; putative drug target function;	Phase 4: April 2009	1I8D	74.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02287 (show subtarget assignments)	1	soluble	FTT1161	56708232	adk	adenylate kinase [Francisella tularensis...	218	Drug Target	Phase 3: June 2008	1AKE	56.4%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01125 (show subtarget assignments)	1	expressed	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP91602 (show subtarget assignments)	8	expressed	CBU_2056	29542607		hypothetical protein	219	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP90005 (show subtarget assignments)	8	soluble	Z4377	12517595	qseB	quorum sensing Escherichia coli regulato...	219	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3Q9S	41.1%	Escherichia coli

IDP91700 (show subtarget assignments)	8	selected	NP_002791	4506205	PSMB9	proteasome subunit beta type-9 proprotei...	219	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1IRU	55.7%	Homo sapiens

IDP91587 (show subtarget assignments)	8	expressed	CBU_1108	29541682		hypothetical protein	219	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP91546 (show subtarget assignments)	8	selected	AAA26683	398085	vat	acetyltransferase [Staphylococcus aureus...	219	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KHR	57.5%	Staphylococcus aureus

IDP91743 (show subtarget assignments)	8	selected	Q76ZN6_VACCW	0			219	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2VGA	90.9%	Vaccinia virus

IDP91359 (show subtarget assignments)	8	purified	VV1_2847	27366129		response regulator [Vibrio vulnificus CM...	219	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1KGS	41.1%	Vibrio vulnificus

IDP02106 (show subtarget assignments)	1	cloned	FTT0654	56707776	elbB	isoprenoid biosynthesis protein [Francis...	219	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1OY1	47.5%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02811 (show subtarget assignments)	1	soluble	STM1880	16765222	yebE	putative inner membrane protein [Salmone...	219	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01800 (show subtarget assignments)	1	soluble	GBAA1129	47526399		S-layer protein, putative [Bacillus anth...	219	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.1%	Bacillus anthracis	Cell envelope	Surface structures

IDP04585 (show subtarget assignments)	1	purified	BAS0116	49183150		30S ribosomal protein S3 [Bacillus anthr...	219	Proposed to be essential proteins	Phase 4: April 2009	1VS5	54.3%	Bacillus anthracis

IDP00408 (show subtarget assignments)	1	cloned	YPO2735	16122939	ccmB	heme exporter protein B	219	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90124 (show subtarget assignments)	8	cloned	MPXV_ZAI1979_005_036	68449110		unknown [Monkeypox virus]	219	mitochondrial-associated inhibitor of apoptosis, similar to VACV-COP-F1L, MPXV-Z...	Community Requests	2VTY	69.4%	Monkeypox virus

IDP00704 (show subtarget assignments)	1	expressed	SACOL0264	57286724		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	32%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00676 (show subtarget assignments)	1	expressed	SACOL1492	57284593	nth	endonuclease III	219	Drug Target Function	Phase 2: March 2008	1ORN	62.1%	Staphylococcus aureus	DNA metabolism	DNA replication, recombination, and repair

IDP91363 (show subtarget assignments)	8	expressed	VV1_2834	27366116		secreted hydrolase [Vibrio vulnificus CM...	219	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2ICH	28.6%	Vibrio vulnificus

IDP90083 (show subtarget assignments)	8	cloned	ZP_01795671	145640077		hypothetical protein CGSHiII_00664 [Haem...	219	The protein we would like structure analyzed is from Haemophilus influenzae. Pri...	Community Requests	2XM6	35.6%	Haemophilus influenzae

IDP90271 (show subtarget assignments)	8	in_pdb 3M5R 3M8A	ACP44186	227977167	NS1	nonstructural protein 1 [Influenza A vir...	219	swine flu virus	Community Requests	3F5T	79.9%	Influenza A

IDP00836
(show subtarget assignments)

1

in_pdb
3GIU

SACOL2714

57285268

pcp

pyrrolidone-carboxylate peptidase

212

Drug Target Function

Phase 2: March 2008

3GIU

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01467
(show subtarget assignments)

1

purified

VC2549

15642544

methionine sulfoxide reductase A

212

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

56.1%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP04477
(show subtarget assignments)

1

soluble

YPO2829

115348505

purN

putative phosphoribosylglycinamide formy...

212

conserved gene; putative drug target function;

Phase 4: April 2009

2GAR

71.7%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90794
(show subtarget assignments)

8

soluble

Cj0763c

15792101

cysE

serine acetyltransferase [Campylobacter ...

212

Predicted Essential

Community Requests

3P1B

34.9%

Campylobacter jejuni

IDP00932
(show subtarget assignments)

1

purified

STM0645

16764022

nadD

nicotinic acid mononucleotide adenyltran...

213

Conserved Gene / Pathway

Phase 2: March 2008

1K4K

85.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP91573
(show subtarget assignments)

8

soluble

BAB35577

13361620

ECs2154

hypothetical protein [Escherichia coli O...

213

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

19.7%

Escherichia coli

IDP91572
(show subtarget assignments)

8

soluble

BAB35419

13361461

ECs1996

hypothetical protein [Escherichia coli O...

213

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

20.2%

Escherichia coli

IDP05211
(show subtarget assignments)

1

cloned

CD2574

126700193

putative thiamine pyrophosphokinase [Clo...

213

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3IHK

28.8%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP00716
(show subtarget assignments)

1

purified

SACOL1420

57286071

phosphate transport system protein PhoU,...

213

Conserved Gene / Pathway

Phase 2: March 2008

1T72

31%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP00036
(show subtarget assignments)

1

purified

BA_1840

30256110

fibronectin-binding protein, putative

213

Virulence

Phase 1: October 2007

2YB5

32.9%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP05440
(show subtarget assignments)

1

soluble

BA_3272

30257827

hypothetical protein BA_3272 [Bacillus a...

213

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP02032
(show subtarget assignments)

1

expressed

YPO0013

16120366

mobA

molybdopterin-guanine dinucleotide biosy...

213

Involved in virulence; Drug target functions

Phase 3: June 2008

1E5K

39.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP05534
(show subtarget assignments)

1

purified

CD3106

126700723

putative phopho-sugar aldolase [Clostrid...

213

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WX0

33.3%

Clostridium difficile

Unknown function: General

IDP90420
(show subtarget assignments)

8

cloned

CT_465

3328899

hypothetical protein [Chlamydia trachoma...

213

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04500
(show subtarget assignments)

1

purified

VC0986

15641001

adk

adenylate kinase [Vibrio cholerae O1 bio...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AKE

73.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP91820
(show subtarget assignments)

8

selected

b0474

1786680

adk

adenylate kinase [Escherichia coli str. ...

214

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1AKE

100%

Escherichia coli

IDP02752
(show subtarget assignments)

1

crystallized

FTT0650c

56707772

grxB

glutaredoxin 2 [Francisella tularensis s...

214

Drug Target

Phase 3: June 2008

3IR4

30.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP05053
(show subtarget assignments)

1

expressed

CD0242

126697813

hypothetical protein CD0242 [Clostridium...

214

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3D5N

18.7%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP90221
(show subtarget assignments)

8

cloned

MYXV_gp157

9633790

m154L

m154L, gp120-like

214

NFkB inhibitor, similar to VACV-Cop:M2L

Community Requests

Myxoma virus

host defense modulator

0

IDP00480
(show subtarget assignments)

1

soluble

YPO3118

16123283

adk

adenylate kinase

214

Conserved Gene / Pathway

Phase 2: March 2008

1AKE

87.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04642
(show subtarget assignments)

1

expressed

FTT0716

56707835

upp

uracil phosphoribosyltransferase [Franci...

214

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2EHJ

69.2%

Francisella tularensis

IDP00779
(show subtarget assignments)

1

soluble

SACOL0691

57285661

sirR

iron-dependent repressor

214

Conserved Gene / Pathway

Phase 2: March 2008

3HRS

37.4%

Staphylococcus aureus

Regulatory functions

DNA interactions

IDP01847
(show subtarget assignments)

1

soluble

GBAA5416

47530729

ftsE

cell division ABC transporter, ATP-bindi...

214

Conserved; Drug target functions

Phase 3: June 2008

3DHW

41.1%

Bacillus anthracis

Cellular processes

Cell division

IDP90785
(show subtarget assignments)

8

in_pdb
3N2L

VC0211

15640241

pyrE

orotate phosphoribosyltransferase [Vibri...

214

Predicted Essential

Community Requests

3N2L

100%

Vibrio cholerae

IDP02145
(show subtarget assignments)

1

cloned

YPO1301

16121583

psaE

putative regulatory protein [Yersinia pe...

214

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP05588
(show subtarget assignments)

1

cloned

BA_2883

30257480

putative lipoprotein [Bacillus anthracis...

214

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP90372
(show subtarget assignments)

8

expressed

CT_253

3328664

hypothetical protein [Chlamydia trachoma...

215

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02531
(show subtarget assignments)

1

in_pdb
3LAC

GBAA3090

50196941

pcP

pyrrolidone-carboxylate peptidase [Bacil...

215

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LAC

99.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04287
(show subtarget assignments)

1

cloned

YPO2703

115348386

pcp

putative pyrrolidone-carboxylate peptida...

215

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3LAC

54%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04700
(show subtarget assignments)

1

cloned

YPO0045

218927266

pyrE

orotate phosphoribosyltransferase [Yersi...

215

conserved gene; putative drug target function;

Phase 4: April 2009

1LH0

85.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90212
(show subtarget assignments)

8

cloned

MYXV_gp067

9633699

m063R

m063R, m63R

215

CD47-like

Community Requests

Myxoma virus

host range factor, host defense modulator

0

IDP05727
(show subtarget assignments)

1

cloned

BA_4605

30259105

conserved hypothetical protein [Bacillus...

215

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP00895
(show subtarget assignments)

1

in_pdb
3IR4

STM1165

16764521

grxB

glutaredoxin 2

215

Conserved Gene / Pathway

Phase 2: March 2008

3IR4

100%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP00887
(show subtarget assignments)

1

expressed

STM2349

16765676

yfcG

putative glutathione S-transferase

215

Conserved Gene / Pathway

Phase 2: March 2008

3GX0

80.5%

Salmonella enterica

Cellular processes

Detoxification

IDP01486
(show subtarget assignments)

1

in_pdb
3IEB
3JR2

VCA0242

15601010

ulaD

3-keto-L-gulonate-6-phosphate decarboxyl...

215

Conserved Gene / Pathway

Phase 2: March 2008

3IEB

100%

Vibrio cholerae

Energy metabolism

Sugars

IDP02052
(show subtarget assignments)

1

cloned

YPO2924

16123111

hypothetical protein YPO2924 [Yersinia p...

215

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP90710
(show subtarget assignments)

8

purified

Cj0451

15791815

rep

ribulose-phosphate 3-epimerase [Campylob...

215

Predicted Essential

Community Requests

1RPX

48.4%

Campylobacter jejuni

IDP00165
(show subtarget assignments)

1

cloned

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91570
(show subtarget assignments)

8

expressed

BAB35247

13361289

ECs1824

hypothetical protein [Escherichia coli O...

215

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

17.7%

Escherichia coli

IDP00618
(show subtarget assignments)

1

soluble

SACOL2348

57285082

drug transporter, putative

215

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04119
(show subtarget assignments)

1

purified

BAS0131

49183165

adenylate kinase [Bacillus anthracis str...

216

Proposed to be essential proteins

Phase 4: April 2009

1ZIN

74.1%

Bacillus anthracis

IDP02448
(show subtarget assignments)

1

in_pdb
3KD3

FTT0568

56707697

hypothetical protein FTT0568 [Francisell...

216

Drug Target

Phase 3: June 2008

3KD3

100%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP04417
(show subtarget assignments)

1

purified

FTT0033

56707213

nuoC

NADH dehydrogenase I [Francisella tulare...

216

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2FUG

21.8%

Francisella tularensis

IDP05295
(show subtarget assignments)

1

cloned

CD1816

126699424

cmk

cytidylate kinase [Clostridium difficile...

216

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Q3T

44.4%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05316
(show subtarget assignments)

1

in_pdb
3SD7

CD3605

126701232

putative phosphatase [Clostridium diffic...

216

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3SD7

100%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions

IDP00508
(show subtarget assignments)

1

expressed

YPO1315

16121597

putative hydrolase

216

Conserved Gene / Pathway

Phase 2: March 2008

3FVV

35.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP04701
(show subtarget assignments)

1

expressed

YPO0270

115346088

putative type III secretion apparatus pr...

216

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cellular processes

Pathogenesis

IDP00194
(show subtarget assignments)

1

cloned

YPO0983

16121287

-

putative membrane protein

216

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP90853
(show subtarget assignments)

8

cloned

YPO0647

16120972

putative glycerol-3-phosphate acyltransf...

216

Predicted Essential

Community Requests

Yersinia pestis

IDP00041
(show subtarget assignments)

1

purified

BA_2409

30257040

chloramphenicol acetyltransferase

216

Virulence

Phase 1: October 2007

1QCA

41.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02630
(show subtarget assignments)

1

expressed

STM2899

16766205

invF

invasion regulatory protein [Salmonella ...

216

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP91502
(show subtarget assignments)

8

expressed

VP1672

28898446

type III secretion system protein [Vibri...

216

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP01376
(show subtarget assignments)

1

soluble

VC0400

15640427

MSHA biogenesis protein MshJ

216

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91614
(show subtarget assignments)

8

purified

BAB36909

13362957

ECs3486

hypothetical protein [Escherichia coli O...

216

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

14.4%

Escherichia coli

IDP91817
(show subtarget assignments)

8

selected

b2217

1788546

rcsB

DNA-binding response regulator in two-co...

216

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1P4W

36.6%

Escherichia coli

IDP05429
(show subtarget assignments)

1

cloned

lmo0791

16802833

-

hypothetical protein lmo0791 [Listeria m...

216

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP90641
(show subtarget assignments)

8

purified

Cj0099

15791487

birA

biotin--protein ligase [Campylobacter je...

217

Predicted Essential

Community Requests

2EAY

27.2%

Campylobacter jejuni

IDP00578
(show subtarget assignments)

1

purified

YPO3553

16123697

elbB

isoprenoid biosynthesis protein with ami...

217

Drug Target Function

Phase 2: March 2008

1OY1

63.6%

Yersinia pestis

Unknown function

General

IDP04471
(show subtarget assignments)

1

purified

YPO2370

218929461

pdxH

pyridoxamine 5'-phosphate oxidase [Yersi...

217

conserved gene; putative drug target function;

Phase 4: April 2009

1G76

78.4%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02371
(show subtarget assignments)

1

expressed

CBU_1904

29542461

ftsE

cell division ABC transporter, ATP-bindi...

217

Conserved; Drug target functions

Phase 3: June 2008

1F3O

38.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02616
(show subtarget assignments)

1

in_pdb
3LHQ

STM0477

16763857

acrR

DNA-binding transcriptional repressor Ac...

217

Conserved; Drug target functions

Phase 3: June 2008

3LHQ

100%

Salmonella enterica

Transport and binding proteins

Other

IDP04062
(show subtarget assignments)

1

purified

VCA0637

9658051

oxygen-insensitive NAD(P)H nitroreductas...

217

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HZN

59.4%

Vibrio cholerae

Central intermediary metabolism

Other

IDP00923
(show subtarget assignments)

1

in_pdb
3HZN

STM0578

16763955

nfnB

dihydropteridine reductase

217

Conserved Gene / Pathway

Phase 2: March 2008

3HZN

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP01748
(show subtarget assignments)

1

soluble

PSLT011

17233476

srgA

putative thiol-disulfide isomerase or th...

217

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3L9V

85.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00479
(show subtarget assignments)

1

in_pdb
3H07

YPO0658

16120983

ribB

3,4-dihydroxy-2-butanone 4-phosphate syn...

217

Conserved Gene / Pathway

Phase 2: March 2008

3H07

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90588
(show subtarget assignments)

8

cloned

Q9KLX5

23821639

RecName: Full=GTP cyclohydrolase 1; AltN...

217

Predicted Essential

Community Requests

1FBX

70.5%

Vibrio cholerae

IDP91802
(show subtarget assignments)

8

crystallized

lpg0123

52840378

dsbA

thiol:disulfide interchange protein DsbA...

217

virulence/pathogenesis / Legionella pneumophila is most closely related to Coxiella burnetti, the causati...

Community Requests

3L9S

27.6%

Legionella pneumophila

IDP04354
(show subtarget assignments)

1

expressed

YPCD1.44

5832464

YPCD1.44

putative Yop secretion membrane protein ...

217

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Surface structures

IDP90507
(show subtarget assignments)

8

soluble

VC2270

15642268

riboflavin synthase subunit alpha [Vibri...

217

Predicted Essential

Community Requests

1KZL

35.5%

Vibrio cholerae

IDP02769
(show subtarget assignments)

1

cloned

FTT0304c

56707457

nfnB

dihydropteridine reductase [Francisella ...

217

Drug Target

Phase 3: June 2008

3HZN

45.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP00850
(show subtarget assignments)

1

soluble

SACOL2389

57285120

transcriptional regulatory protein DegU,...

217

Conserved Gene / Pathway

Phase 2: March 2008

1A04

31.3%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP91409
(show subtarget assignments)

8

cloned

VV1_0717

27364172

hypothetical protein VV1_0717 [Vibrio vu...

217

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91615
(show subtarget assignments)

8

purified

BAB36137

13362182

ECs2714

hypothetical protein [Escherichia coli O...

217

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP91270
(show subtarget assignments)

8

selected

NT05BA3459

49180224

acetyltransf2, N-acetyltransferase [Baci...

217

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LNB

47.9%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP04037
(show subtarget assignments)

1

in_pdb
3S52

YPO2082

115347800

putative fumarylacetoacetate hydrolase f...

218

putative drug target function;

Phase 4: April 2009

3S52

100%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00529
(show subtarget assignments)

1

expressed

YPO2734

16122938

ccmA

putative heme exporter protein A

218

Virulence Associated Factor

Phase 2: March 2008

1B0U

27.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90938
(show subtarget assignments)

8

cloned

NMPDR 243277.1.peg.3917

218

Predicted Essential

Community Requests

2JGV

22.5%

Vibrio cholerae

IDP05582
(show subtarget assignments)

1

cloned

BA_1978

30256633

putative lipoprotein [Bacillus anthracis...

218

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP01798
(show subtarget assignments)

1

cloned

GBAA1130

47526400

S-layer protein, putative [Bacillus anth...

218

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.2%

Bacillus anthracis

Cell envelope

Surface structures

IDP04105
(show subtarget assignments)

1

purified

YPO2391

115348093

ribC

riboflavin synthase alpha chain [Yersini...

218

conserved gene; putative drug target function;

Phase 4: April 2009

1I8D

74.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02287
(show subtarget assignments)

1

soluble

FTT1161

56708232

adk

adenylate kinase [Francisella tularensis...

218

Drug Target

Phase 3: June 2008

1AKE

56.4%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01125
(show subtarget assignments)

1

expressed

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP91602
(show subtarget assignments)

8

expressed

CBU_2056

29542607

hypothetical protein

219

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP90005
(show subtarget assignments)

8

soluble

Z4377

12517595

qseB

quorum sensing Escherichia coli regulato...

219

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3Q9S

41.1%

Escherichia coli

IDP91700
(show subtarget assignments)

8

selected

NP_002791

4506205

PSMB9

proteasome subunit beta type-9 proprotei...

219

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1IRU

55.7%

Homo sapiens

IDP91587
(show subtarget assignments)

8

expressed

CBU_1108

29541682

hypothetical protein

219

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP91546
(show subtarget assignments)

8

selected

AAA26683

398085

vat

acetyltransferase [Staphylococcus aureus...

219

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KHR

57.5%

Staphylococcus aureus

IDP91743
(show subtarget assignments)

8

selected

Q76ZN6_VACCW

0

219

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2VGA

90.9%

Vaccinia virus

IDP91359
(show subtarget assignments)

8

purified

VV1_2847

27366129

response regulator [Vibrio vulnificus CM...

219

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1KGS

41.1%

Vibrio vulnificus

IDP02106
(show subtarget assignments)

1

cloned

FTT0654

56707776

elbB

isoprenoid biosynthesis protein [Francis...

219

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1OY1

47.5%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02811
(show subtarget assignments)

1

soluble

STM1880

16765222

yebE

putative inner membrane protein [Salmone...

219

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01800
(show subtarget assignments)

1

soluble

GBAA1129

47526399

S-layer protein, putative [Bacillus anth...

219

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.1%

Bacillus anthracis

Cell envelope

Surface structures

IDP04585
(show subtarget assignments)

1

purified

BAS0116

49183150

30S ribosomal protein S3 [Bacillus anthr...

219

Proposed to be essential proteins

Phase 4: April 2009

1VS5

54.3%

Bacillus anthracis

IDP00408
(show subtarget assignments)

1

cloned

YPO2735

16122939

ccmB

heme exporter protein B

219

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90124
(show subtarget assignments)

8

cloned

MPXV_ZAI1979_005_036

68449110

unknown [Monkeypox virus]

219

mitochondrial-associated inhibitor of apoptosis, similar to VACV-COP-F1L, MPXV-Z...

Community Requests

2VTY

69.4%

Monkeypox virus

IDP00704
(show subtarget assignments)

1

expressed

SACOL0264

57286724

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

32%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00676
(show subtarget assignments)

1

expressed

SACOL1492

57284593

nth

endonuclease III

219

Drug Target Function

Phase 2: March 2008

1ORN

62.1%

Staphylococcus aureus

DNA metabolism

DNA replication, recombination, and repair

IDP91363
(show subtarget assignments)

8

expressed

VV1_2834

27366116

secreted hydrolase [Vibrio vulnificus CM...

219

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2ICH

28.6%

Vibrio vulnificus

IDP90083
(show subtarget assignments)

8

cloned

ZP_01795671

145640077

hypothetical protein CGSHiII_00664 [Haem...

219

The protein we would like structure analyzed is from Haemophilus influenzae. Pri...

Community Requests

2XM6

35.6%

Haemophilus influenzae

IDP90271
(show subtarget assignments)

8

in_pdb
3M5R
3M8A

ACP44186

227977167

NS1

nonstructural protein 1 [Influenza A vir...

219

swine flu virus

Community Requests

3F5T

79.9%

Influenza A