Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04585 (show subtarget assignments)	1	purified	BAS0116	49183150		30S ribosomal protein S3 [Bacillus anthr...	219	Proposed to be essential proteins	Phase 4: April 2009	1VS5	54.3%	Bacillus anthracis

IDP00057 (show subtarget assignments)	1	soluble	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP90120 (show subtarget assignments)	8	cloned	MPXV_ZAI1979_005_030	68449104		unknown [Monkeypox virus]	220	similar to VACV-COP-M2L, MPXV-ZAI96-O2L	Community Requests			Monkeypox virus

IDP00909 (show subtarget assignments)	0	work_stopped	STM0171	16763561	yadF	carbonic anhydrase	220	Conserved Gene / Pathway	Phase 2: March 2008	3QY1	100%	Salmonella enterica	Central intermediary metabolism	Other

IDP91195 (show subtarget assignments)	8	cloned	BAS4091	49187089	-	Stage III sporulation protein AG	220	essential/virulence/pathogenesis / Essential proteins	Community Requests			Bacillus anthracis

IDP90767 (show subtarget assignments)	8	soluble	YPO2607	16122820	nadD	nicotinic acid mononucleotide adenylyltr...	220	Predicted Essential	Community Requests	1K4K	56.4%	Yersinia pestis

IDP01770 (show subtarget assignments)	1	expressed	Cj1447c	15792764	kpsT	capsular polysaccharide ABC transporter,...	220	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2BBS	26.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02263 (show subtarget assignments)	1	in_pdb 3U7I	GBAA0966	47526249		hypothetical protein GBAA0966 [Bacillus ...	220	Conserved; Essential;	Phase 3: June 2008	3U7I	100%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP90846 (show subtarget assignments)	8	crystallized	YPO1505	16121778	folE	GTP cyclohydrolase I [Yersinia pestis CO...	220	Predicted Essential	Community Requests	1FBX	89.5%	Yersinia pestis

IDP01713 (show subtarget assignments)	1	soluble	YPO3407	16123556		putative carbonic anhydrase [Yersinia pe...	220	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1I6O	70.5%	Yersinia pestis	Central intermediary metabolism	Other

IDP00172 (show subtarget assignments)	1	purified	YPO2438	16122659	-	putative membrane-bound lytic murein tra...	220	Virulence	Phase 1: October 2007	2Y8P	42.7%	Yersinia pestis	Mobile and extrachromosomal element functions	Prophage functions

IDP02504 (show subtarget assignments)	1	purified	FTT1578c	56708604	ung	uracil-DNA glycosylase [Francisella tula...	220	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1EUG	58.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00731 (show subtarget assignments)	1	soluble	SACOL2462	57286457		ABC transporter, ATP-binding protein	220	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP00666 (show subtarget assignments)	1	purified	SACOL1096	57285882		TrkA potassium uptake family protein	220	Drug Target Function	Phase 2: March 2008	2HMS	36.4%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP91446 (show subtarget assignments)	8	expressed	VV1_0392	27363860		HD superfamily hydrolase [Vibrio vulnifi...	220	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP05445 (show subtarget assignments)	1	cloned	lmo0821	16802863	-	hypothetical protein lmo0821 [Listeria m...	220	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP04640 (show subtarget assignments)	1	purified	FTT0559c	56707689	cmk	cytidylate kinase [Francisella tularensi...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CKE	47.1%	Francisella tularensis

IDP05129 (show subtarget assignments)	1	cloned	CD0091	126697661	adk	adenylate kinase [Clostridium difficile ...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FB4	57.9%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01104 (show subtarget assignments)	1	soluble	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP90311 (show subtarget assignments)	8	cloned	CT_734	3329192		hypothetical protein [Chlamydia trachoma...	221	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05131 (show subtarget assignments)	1	cloned	CD0260	126697832	fliP	flagellar biosynthesis protein FliP [Clo...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04566 (show subtarget assignments)	1	expressed	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP05430 (show subtarget assignments)	1	cloned	lmo1265	16803305	-	hypothetical protein lmo1265 [Listeria m...	221	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02535 (show subtarget assignments)	1	expressed	GBAA0088	47525343	cysE	serine O-acetyltransferase [Bacillus ant...	221	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GVD	36.2%	Bacillus anthracis	Amino acid biosynthesis	Serine family

IDP92031 (show subtarget assignments)	8	selected	TGME49_019760	237842861		N-terminal acetyltransferase complex sub...	221	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP05517 (show subtarget assignments)	1	soluble	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP90140 (show subtarget assignments)	8	expressed	MPXV_ZAI1979_005_184	68449255		6kDa intracellular viral protein [Monkey...	221	similar to VACV-COP-B9R, MPXV-ZAI96-B10R	Community Requests			Monkeypox virus

IDP00729 (show subtarget assignments)	1	soluble	SACOL2356	57285089		ABC transporter, ATP-binding protein	221	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP02070 (show subtarget assignments)	1	expressed	CBU_1809	29542365		ABC transporter, ATP-binding protein [Co...	221	Conserved; Drug target functions	Phase 3: June 2008	1F3O	49.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01938 (show subtarget assignments)	1	soluble	Cj1423c	15792741		putative sugar-phosphate nucleotidyltran...	221	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	33.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91958 (show subtarget assignments)	8	selected	SpneCM_010100004562	298254871		Trk family potassium uptake protein [Str...	221	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1LSU	20.8%	Streptococcus pneumoniae

IDP01081 (show subtarget assignments)	1	soluble	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	3LQ7	24.8%	Salmonella enterica	Cellular processes	Detoxification

IDP02687 (show subtarget assignments)	1	cloned	lmo2580	16804618		hypothetical protein lmo2580 [Listeria m...	222	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	46.8%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP00547 (show subtarget assignments)	1	expressed	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP00990 (show subtarget assignments)	0	work_stopped	STM2193	16765523	folE	GTP cyclohydrolase I	222	Conserved Gene / Pathway	Phase 2: March 2008	1FBX	95.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP05097 (show subtarget assignments)	1	cloned	CD0226	126697797		putative transglycosylase [Clostridium d...	222	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91624 (show subtarget assignments)	8	expressed	BAB35497	13361540	ECs2074	hypothetical protein [Escherichia coli O...	222	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP01809 (show subtarget assignments)	1	purified	FTT0258	56707414		carboxylesterase/phospholipase family pr...	222	Drug Target	Phase 3: June 2008	1FJ2	39.6%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP00865 (show subtarget assignments)	1	expressed	STM3570	16766856	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	41.9%	Salmonella enterica	Cellular processes	Cell division

IDP91921 (show subtarget assignments)	8	selected	SpneCM_010100000547	298254088		choline binding protein PcpA, partial [S...	222	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V04	44.6%	Streptococcus pneumoniae

IDP02542 (show subtarget assignments)	1	in_pdb 3INP	FTT0789	56707900	rpe	D-ribulose-phosphate 3-epimerase [Franci...	222	Drug Target	Phase 3: June 2008	3INP	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP01476 (show subtarget assignments)	1	soluble	VC2694	15642689		superoxide dismutase, Mn	222	Conserved Gene / Pathway	Phase 2: March 2008	2RCV	48.2%	Vibrio cholerae	Cellular processes	Detoxification

IDP05428 (show subtarget assignments)	1	cloned	lmo0717	16802759	-	hypothetical protein lmo0717 [Listeria m...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Viral functions: General

IDP90517 (show subtarget assignments)	8	in_pdb 3UGS	Cj0824	15792162	uppS	undecaprenyl diphosphate synthase [Campy...	222	Predicted Essential	Community Requests	3UGS	100%	Campylobacter jejuni

IDP04089 (show subtarget assignments)	1	expressed	STM1952_1_222	16765290	yecS	putative ABC-type amino acid transporter...	222	Salmonella essential protein	Phase 4: April 2009	2R6G	24.3%	Salmonella enterica

IDP05330 (show subtarget assignments)	1	soluble	BA_2605	30257222		putative lipoprotein [Bacillus anthracis...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05086 (show subtarget assignments)	1	soluble	BA_0014	30253529		deoxynucleoside kinase family protein [B...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2A2Z	29.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP02132 (show subtarget assignments)	1	cloned	GBAA1892	47527187	dra	deoxyribose-phosphate aldolase [Bacillus...	223	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NGJ	57.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP01082 (show subtarget assignments)	1	expressed	STM4279	16767529	nrfC	putative formate-dependent nitrite reduc...	223	Essential Gene	Phase 2: March 2008	2VPW	35.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP01816 (show subtarget assignments)	1	purified	STM3193	16766493		putative disulfide bond formation protei...	223	Conserved; Drug target functions	Phase 3: June 2008	3L9U	89.2%	Salmonella enterica	Protein synthesis	Translation factors

IDP01810 (show subtarget assignments)	1	cloned	STM3187	16766487	ygiB	hypothetical protein STM3187 [Salmonella...	223	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01799 (show subtarget assignments)	1	soluble	GBAA1127	47526398		S-layer protein, putative [Bacillus anth...	223	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.6%	Bacillus anthracis	Cell envelope	Surface structures

IDP05572 (show subtarget assignments)	1	cloned	BAS4090	49187088	-	stage III sporulation protein AH [Bacill...	223	essential/virulence/pathogenesis / associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP90680 (show subtarget assignments)	8	purified	Cj1401c	15792719	tpiA	triosephosphate isomerase [Campylobacter...	223	Predicted Essential	Community Requests	2JGQ	48.2%	Campylobacter jejuni

IDP90421 (show subtarget assignments)	8	expressed	CT_433	3328864		hypothetical protein [Chlamydia trachoma...	223	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90406 (show subtarget assignments)	8	soluble	CT_668	3329119		hypothetical protein [Chlamydia trachoma...	223	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90827 (show subtarget assignments)	8	expressed	Cj0514	15791876	purQ	phosphoribosylformylglycinamidine syntha...	223	Predicted Essential	Community Requests	3D54	40.4%	Campylobacter jejuni

IDP91194 (show subtarget assignments)	8	cloned	BAS4090	49187088	-	Stage III sporulation protein AH	223	essential/virulence/pathogenesis / Essential proteins	Community Requests			Bacillus anthracis

IDP05309 (show subtarget assignments)	1	purified	CD3128	126700746	pgmB	beta-phosphoglucomutase [Clostridium dif...	223	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3NAS	47.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91559 (show subtarget assignments)	8	expressed	BAB38077	13364129	ECs4654	hypothetical protein [Escherichia coli O...	223	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP91400 (show subtarget assignments)	8	cloned	VV1_1002	27364436		ABC-type amino acid transport system, pe...	223	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DHW	23.3%	Vibrio vulnificus

IDP91576 (show subtarget assignments)	8	purified	BAB37281	13363330	ECs3858	hypothetical protein [Escherichia coli O...	224	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP02119 (show subtarget assignments)	1	in_pdb 3KWM	FTT1208	56708271	rpiA	ribose-5-phosphate isomerase A [Francise...	224	Conserved; Drug target functions	Phase 3: June 2008	3KWM	100%	Francisella tularensis	Energy metabolism	Pentose phosphate pathway

IDP00215 (show subtarget assignments)	1	cloned	YPO2295	16122519	-	haloacid dehalogenase-like hydrolase fam...	224	Virulence	Phase 1: October 2007	3ED5	31.6%	Yersinia pestis	Hypothetical proteins	Conserved

IDP92083 (show subtarget assignments)	8	selected	TGME49_109210	237829785		peroxidoxin 2 [Toxoplasma gondii ME49]	224	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP02282 (show subtarget assignments)	1	cloned	FTT0491c	56707633	gph	phosphoglycolate phosphatase [Francisell...	224	Drug Target	Phase 3: June 2008	2HSZ	32.6%	Francisella tularensis	Energy metabolism	Sugars

IDP90283 (show subtarget assignments)	8	cloned	TGME49_075440	211969603	GRA6	granule antigen protein GRA6 [Toxoplasma...	224	GRA6 is a secreted dense granule protein that generates protective immunity, e.g...	Community Requests			Toxoplasma gondii

IDP90862 (show subtarget assignments)	8	in_pdb 3O2R 3N3W	Cj1635c	15792940	rnc	ribonuclease III [Campylobacter jejuni s...	224	Predicted Essential	Community Requests	3N3W	100%	Campylobacter jejuni

IDP02572 (show subtarget assignments)	1	soluble	lmo1939	16803978	cmk	hypothetical protein lmo1939 [Listeria m...	224	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	1Q3T	59.4%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP04456 (show subtarget assignments)	1	soluble	YPO1382	115347141		hypothetical protein [Yersinia pestis CO...	224	drug target; virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP01156 (show subtarget assignments)	1	expressed	BA_0798	30254389		ABC transporter, ATP-binding protein	224	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	50.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01942 (show subtarget assignments)	1	purified	lmo1745	16803785		hypothetical protein lmo1745 [Listeria m...	225	Known virulence-Regulation; PMID:16102006	Phase 3: June 2008	2OQR	34.2%	Listeria monocytogenes	Regulatory functions	Other

IDP01987 (show subtarget assignments)	1	soluble	YPO0155	16120498	rpe	ribulose-phosphate 3-epimerase [Yersinia...	225	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3INP	63.1%	Yersinia pestis	Energy metabolism	Pentose phosphate pathway

IDP00223 (show subtarget assignments)	1	purified	YPO3054	16123231	-	putative carboxypeptidase	225	Virulence	Phase 1: October 2007			Yersinia pestis

IDP04539 (show subtarget assignments)	8	purified	CAC05775	12329044	ospD1	OspD1, secreted by the Mxi-Spa secretion...	225	Shigella effector protein	Community Requests			Shigella flexneri

IDP05162 (show subtarget assignments)	1	soluble	BA_1701	30255991		hypothetical protein BA_1701 [Bacillus a...	225	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04109 (show subtarget assignments)	1	crystallized	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01786 (show subtarget assignments)	1	expressed	CBU_0502	29541107		hydrolase, putative [Coxiella burnetii R...	225	Conserved; Drug target functions	Phase 3: June 2008	2GZX	44.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02289 (show subtarget assignments)	1	in_pdb 3OF5	FTT0934c	56708031	bioD	dethiobiotin synthetase [Francisella tul...	225	Conserved; Drug target functions	Phase 3: June 2008	3OF5	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01662 (show subtarget assignments)	1	purified	lmo2583	16804621		hypothetical protein lmo2583 [Listeria m...	225	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	39.1%	Listeria monocytogenes	Regulatory functions	Other

IDP90855 (show subtarget assignments)	8	cloned	VC2461	15642457	rnc	ribonuclease III [Vibrio cholerae O1 bio...	225	Predicted Essential	Community Requests	2A11	43.3%	Vibrio cholerae

IDP01520 (show subtarget assignments)	1	expressed	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00705 (show subtarget assignments)	1	cloned	SACOL0306	57285419		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	39%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP90888 (show subtarget assignments)	8	purified	Q9KQT2	22001682		RecName: Full=Cytidylate kinase; Short=C...	225	Predicted Essential	Community Requests	1CKE	70.2%	Vibrio cholerae

IDP05093 (show subtarget assignments)	1	cloned	lmo0193	16802239	-	hypothetical protein lmo0193 [Listeria m...	225	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FPP	22.7%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP90195 (show subtarget assignments)	8	soluble	AAM13642.1	20153181	CPXV203 CDS	CPXV203 protein	225	ER-localized, MHC-I inhibitor	Community Requests			Cowpox virus	host defense modulator	0

IDP01198 (show subtarget assignments)	1	purified	BA_1518	59798071		Cytidylate kinase (CK) (Cytidine monopho...	225	Conserved Gene / Pathway	Phase 2: March 2008	1Q3T	53.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP05763 (show subtarget assignments)	1	cloned	lmo2331	16804370	-	hypothetical protein lmo2331 [Listeria m...	226	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05298 (show subtarget assignments)	1	purified	CD2189	126699805	pgmB	beta-phosphoglucomutase [Clostridium dif...	226	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3NAS	46.9%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91880 (show subtarget assignments)	8	selected	NP_464280	16802795		hypothetical protein lmo0753 [Listeria m...	226	essential/virulence/pathogenesis / lmo0753 (681-nt, 226-aa) is one of the few Crp/Fnr family transcription factors ...	Community Requests	3D0S	21.2%	Listeria monocytogenes

IDP91757 (show subtarget assignments)	8	selected	VF01_VACCW	0			226	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2VTY	73%	Vaccinia virus

IDP02231 (show subtarget assignments)	1	purified	lmo1377	16803417	lisR	two-component response regulator [Lister...	226	Known virulence-Regulation; Predicted virulence-Resistance to antibiotics and to...	Phase 3: June 2008	1KGS	41.4%	Listeria monocytogenes	Regulatory functions	Other

IDP05645 (show subtarget assignments)	1	cloned	CD3297	126700916		hypothetical protein CD3297 [Clostridium...	226	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP00831 (show subtarget assignments)	0	work_stopped	SACOL2545	57285227	sdaAB	L-serine dehydratase, iron-sulfur-depend...	226	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP02631 (show subtarget assignments)	1	expressed	GBAA1440	47526715	cysH	phosphoadenosine phosphosulfate reductas...	226	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GOY	37.6%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP02564 (show subtarget assignments)	1	purified	GBAA0084	47525340	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	226	Conserved; Drug target functions	Phase 3: June 2008	1W77	36.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01162 (show subtarget assignments)	1	expressed	BA_5496	30259957		ABC transporter, ATP-binding protein	226	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	54.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP04524 (show subtarget assignments)	1	in_pdb 3Q58	STM1129_1_226	16764486		N-acetylmannosamine-6-phosphate 2-epimer...	226	Salmonella essential protein	Phase 4: April 2009	3Q58	100%	Salmonella enterica

IDP02025 (show subtarget assignments)	1	cloned	lmo0394	16802439		hypothetical protein lmo0394 [Listeria m...	227	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2XIV	19.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP92025 (show subtarget assignments)	8	selected	TGME49_016130	237843251		ubiquitin-conjugating enzyme E2, putativ...	227	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP04585
(show subtarget assignments)

1

purified

BAS0116

49183150

30S ribosomal protein S3 [Bacillus anthr...

219

Proposed to be essential proteins

Phase 4: April 2009

1VS5

54.3%

Bacillus anthracis

IDP00057
(show subtarget assignments)

1

soluble

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP90120
(show subtarget assignments)

8

cloned

MPXV_ZAI1979_005_030

68449104

unknown [Monkeypox virus]

220

similar to VACV-COP-M2L, MPXV-ZAI96-O2L

Community Requests

Monkeypox virus

IDP00909
(show subtarget assignments)

0

work_stopped

STM0171

16763561

yadF

carbonic anhydrase

220

Conserved Gene / Pathway

Phase 2: March 2008

3QY1

100%

Salmonella enterica

Central intermediary metabolism

Other

IDP91195
(show subtarget assignments)

8

cloned

BAS4091

49187089

-

Stage III sporulation protein AG

220

essential/virulence/pathogenesis / Essential proteins

Community Requests

Bacillus anthracis

IDP90767
(show subtarget assignments)

8

soluble

YPO2607

16122820

nadD

nicotinic acid mononucleotide adenylyltr...

220

Predicted Essential

Community Requests

1K4K

56.4%

Yersinia pestis

IDP01770
(show subtarget assignments)

1

expressed

Cj1447c

15792764

kpsT

capsular polysaccharide ABC transporter,...

220

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2BBS

26.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02263
(show subtarget assignments)

1

in_pdb
3U7I

GBAA0966

47526249

hypothetical protein GBAA0966 [Bacillus ...

220

Conserved; Essential;

Phase 3: June 2008

3U7I

100%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP90846
(show subtarget assignments)

8

crystallized

YPO1505

16121778

folE

GTP cyclohydrolase I [Yersinia pestis CO...

220

Predicted Essential

Community Requests

1FBX

89.5%

Yersinia pestis

IDP01713
(show subtarget assignments)

1

soluble

YPO3407

16123556

putative carbonic anhydrase [Yersinia pe...

220

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1I6O

70.5%

Yersinia pestis

Central intermediary metabolism

Other

IDP00172
(show subtarget assignments)

1

purified

YPO2438

16122659

-

putative membrane-bound lytic murein tra...

220

Virulence

Phase 1: October 2007

2Y8P

42.7%

Yersinia pestis

Mobile and extrachromosomal element functions

Prophage functions

IDP02504
(show subtarget assignments)

1

purified

FTT1578c

56708604

ung

uracil-DNA glycosylase [Francisella tula...

220

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1EUG

58.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00731
(show subtarget assignments)

1

soluble

SACOL2462

57286457

ABC transporter, ATP-binding protein

220

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP00666
(show subtarget assignments)

1

purified

SACOL1096

57285882

TrkA potassium uptake family protein

220

Drug Target Function

Phase 2: March 2008

2HMS

36.4%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP91446
(show subtarget assignments)

8

expressed

VV1_0392

27363860

HD superfamily hydrolase [Vibrio vulnifi...

220

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP05445
(show subtarget assignments)

1

cloned

lmo0821

16802863

-

hypothetical protein lmo0821 [Listeria m...

220

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP04640
(show subtarget assignments)

1

purified

FTT0559c

56707689

cmk

cytidylate kinase [Francisella tularensi...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CKE

47.1%

Francisella tularensis

IDP05129
(show subtarget assignments)

1

cloned

CD0091

126697661

adk

adenylate kinase [Clostridium difficile ...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FB4

57.9%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01104
(show subtarget assignments)

1

soluble

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP90311
(show subtarget assignments)

8

cloned

CT_734

3329192

hypothetical protein [Chlamydia trachoma...

221

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05131
(show subtarget assignments)

1

cloned

CD0260

126697832

fliP

flagellar biosynthesis protein FliP [Clo...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04566
(show subtarget assignments)

1

expressed

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP05430
(show subtarget assignments)

1

cloned

lmo1265

16803305

-

hypothetical protein lmo1265 [Listeria m...

221

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02535
(show subtarget assignments)

1

expressed

GBAA0088

47525343

cysE

serine O-acetyltransferase [Bacillus ant...

221

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GVD

36.2%

Bacillus anthracis

Amino acid biosynthesis

Serine family

IDP92031
(show subtarget assignments)

8

selected

TGME49_019760

237842861

N-terminal acetyltransferase complex sub...

221

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP05517
(show subtarget assignments)

1

soluble

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP90140
(show subtarget assignments)

8

expressed

MPXV_ZAI1979_005_184

68449255

6kDa intracellular viral protein [Monkey...

221

similar to VACV-COP-B9R, MPXV-ZAI96-B10R

Community Requests

Monkeypox virus

IDP00729
(show subtarget assignments)

1

soluble

SACOL2356

57285089

ABC transporter, ATP-binding protein

221

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP02070
(show subtarget assignments)

1

expressed

CBU_1809

29542365

ABC transporter, ATP-binding protein [Co...

221

Conserved; Drug target functions

Phase 3: June 2008

1F3O

49.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01938
(show subtarget assignments)

1

soluble

Cj1423c

15792741

putative sugar-phosphate nucleotidyltran...

221

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

33.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91958
(show subtarget assignments)

8

selected

SpneCM_010100004562

298254871

Trk family potassium uptake protein [Str...

221

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1LSU

20.8%

Streptococcus pneumoniae

IDP01081
(show subtarget assignments)

1

soluble

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

3LQ7

24.8%

Salmonella enterica

Cellular processes

Detoxification

IDP02687
(show subtarget assignments)

1

cloned

lmo2580

16804618

hypothetical protein lmo2580 [Listeria m...

222

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

46.8%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP00547
(show subtarget assignments)

1

expressed

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP00990
(show subtarget assignments)

0

work_stopped

STM2193

16765523

folE

GTP cyclohydrolase I

222

Conserved Gene / Pathway

Phase 2: March 2008

1FBX

95.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP05097
(show subtarget assignments)

1

cloned

CD0226

126697797

putative transglycosylase [Clostridium d...

222

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91624
(show subtarget assignments)

8

expressed

BAB35497

13361540

ECs2074

hypothetical protein [Escherichia coli O...

222

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP01809
(show subtarget assignments)

1

purified

FTT0258

56707414

carboxylesterase/phospholipase family pr...

222

Drug Target

Phase 3: June 2008

1FJ2

39.6%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP00865
(show subtarget assignments)

1

expressed

STM3570

16766856

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

41.9%

Salmonella enterica

Cellular processes

Cell division

IDP91921
(show subtarget assignments)

8

selected

SpneCM_010100000547

298254088

choline binding protein PcpA, partial [S...

222

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V04

44.6%

Streptococcus pneumoniae

IDP02542
(show subtarget assignments)

1

in_pdb
3INP

FTT0789

56707900

rpe

D-ribulose-phosphate 3-epimerase [Franci...

222

Drug Target

Phase 3: June 2008

3INP

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP01476
(show subtarget assignments)

1

soluble

VC2694

15642689

superoxide dismutase, Mn

222

Conserved Gene / Pathway

Phase 2: March 2008

2RCV

48.2%

Vibrio cholerae

Cellular processes

Detoxification

IDP05428
(show subtarget assignments)

1

cloned

lmo0717

16802759

-

hypothetical protein lmo0717 [Listeria m...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Viral functions: General

IDP90517
(show subtarget assignments)

8

in_pdb
3UGS

Cj0824

15792162

uppS

undecaprenyl diphosphate synthase [Campy...

222

Predicted Essential

Community Requests

3UGS

100%

Campylobacter jejuni

IDP04089
(show subtarget assignments)

1

expressed

STM1952_1_222

16765290

yecS

putative ABC-type amino acid transporter...

222

Salmonella essential protein

Phase 4: April 2009

2R6G

24.3%

Salmonella enterica

IDP05330
(show subtarget assignments)

1

soluble

BA_2605

30257222

putative lipoprotein [Bacillus anthracis...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05086
(show subtarget assignments)

1

soluble

BA_0014

30253529

deoxynucleoside kinase family protein [B...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2A2Z

29.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP02132
(show subtarget assignments)

1

cloned

GBAA1892

47527187

dra

deoxyribose-phosphate aldolase [Bacillus...

223

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NGJ

57.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP01082
(show subtarget assignments)

1

expressed

STM4279

16767529

nrfC

putative formate-dependent nitrite reduc...

223

Essential Gene

Phase 2: March 2008

2VPW

35.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP01816
(show subtarget assignments)

1

purified

STM3193

16766493

putative disulfide bond formation protei...

223

Conserved; Drug target functions

Phase 3: June 2008

3L9U

89.2%

Salmonella enterica

Protein synthesis

Translation factors

IDP01810
(show subtarget assignments)

1

cloned

STM3187

16766487

ygiB

hypothetical protein STM3187 [Salmonella...

223

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01799
(show subtarget assignments)

1

soluble

GBAA1127

47526398

S-layer protein, putative [Bacillus anth...

223

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.6%

Bacillus anthracis

Cell envelope

Surface structures

IDP05572
(show subtarget assignments)

1

cloned

BAS4090

49187088

-

stage III sporulation protein AH [Bacill...

223

essential/virulence/pathogenesis / associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP90680
(show subtarget assignments)

8

purified

Cj1401c

15792719

tpiA

triosephosphate isomerase [Campylobacter...

223

Predicted Essential

Community Requests

2JGQ

48.2%

Campylobacter jejuni

IDP90421
(show subtarget assignments)

8

expressed

CT_433

3328864

hypothetical protein [Chlamydia trachoma...

223

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90406
(show subtarget assignments)

8

soluble

CT_668

3329119

hypothetical protein [Chlamydia trachoma...

223

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90827
(show subtarget assignments)

8

expressed

Cj0514

15791876

purQ

phosphoribosylformylglycinamidine syntha...

223

Predicted Essential

Community Requests

3D54

40.4%

Campylobacter jejuni

IDP91194
(show subtarget assignments)

8

cloned

BAS4090

49187088

-

Stage III sporulation protein AH

223

essential/virulence/pathogenesis / Essential proteins

Community Requests

Bacillus anthracis

IDP05309
(show subtarget assignments)

1

purified

CD3128

126700746

pgmB

beta-phosphoglucomutase [Clostridium dif...

223

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3NAS

47.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91559
(show subtarget assignments)

8

expressed

BAB38077

13364129

ECs4654

hypothetical protein [Escherichia coli O...

223

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP91400
(show subtarget assignments)

8

cloned

VV1_1002

27364436

ABC-type amino acid transport system, pe...

223

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DHW

23.3%

Vibrio vulnificus

IDP91576
(show subtarget assignments)

8

purified

BAB37281

13363330

ECs3858

hypothetical protein [Escherichia coli O...

224

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP02119
(show subtarget assignments)

1

in_pdb
3KWM

FTT1208

56708271

rpiA

ribose-5-phosphate isomerase A [Francise...

224

Conserved; Drug target functions

Phase 3: June 2008

3KWM

100%

Francisella tularensis

Energy metabolism

Pentose phosphate pathway

IDP00215
(show subtarget assignments)

1

cloned

YPO2295

16122519

-

haloacid dehalogenase-like hydrolase fam...

224

Virulence

Phase 1: October 2007

3ED5

31.6%

Yersinia pestis

Hypothetical proteins

Conserved

IDP92083
(show subtarget assignments)

8

selected

TGME49_109210

237829785

peroxidoxin 2 [Toxoplasma gondii ME49]

224

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP02282
(show subtarget assignments)

1

cloned

FTT0491c

56707633

gph

phosphoglycolate phosphatase [Francisell...

224

Drug Target

Phase 3: June 2008

2HSZ

32.6%

Francisella tularensis

Energy metabolism

Sugars

IDP90283
(show subtarget assignments)

8

cloned

TGME49_075440

211969603

GRA6

granule antigen protein GRA6 [Toxoplasma...

224

GRA6 is a secreted dense granule protein that generates protective immunity, e.g...

Community Requests

Toxoplasma gondii

IDP90862
(show subtarget assignments)

8

in_pdb
3O2R
3N3W

Cj1635c

15792940

rnc

ribonuclease III [Campylobacter jejuni s...

224

Predicted Essential

Community Requests

3N3W

100%

Campylobacter jejuni

IDP02572
(show subtarget assignments)

1

soluble

lmo1939

16803978

cmk

hypothetical protein lmo1939 [Listeria m...

224

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

1Q3T

59.4%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP04456
(show subtarget assignments)

1

soluble

YPO1382

115347141

hypothetical protein [Yersinia pestis CO...

224

drug target; virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP01156
(show subtarget assignments)

1

expressed

BA_0798

30254389

ABC transporter, ATP-binding protein

224

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

50.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01942
(show subtarget assignments)

1

purified

lmo1745

16803785

hypothetical protein lmo1745 [Listeria m...

225

Known virulence-Regulation; PMID:16102006

Phase 3: June 2008

2OQR

34.2%

Listeria monocytogenes

Regulatory functions

Other

IDP01987
(show subtarget assignments)

1

soluble

YPO0155

16120498

rpe

ribulose-phosphate 3-epimerase [Yersinia...

225

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3INP

63.1%

Yersinia pestis

Energy metabolism

Pentose phosphate pathway

IDP00223
(show subtarget assignments)

1

purified

YPO3054

16123231

-

putative carboxypeptidase

225

Virulence

Phase 1: October 2007

Yersinia pestis

IDP04539
(show subtarget assignments)

8

purified

CAC05775

12329044

ospD1

OspD1, secreted by the Mxi-Spa secretion...

225

Shigella effector protein

Community Requests

Shigella flexneri

IDP05162
(show subtarget assignments)

1

soluble

BA_1701

30255991

hypothetical protein BA_1701 [Bacillus a...

225

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04109
(show subtarget assignments)

1

crystallized

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01786
(show subtarget assignments)

1

expressed

CBU_0502

29541107

hydrolase, putative [Coxiella burnetii R...

225

Conserved; Drug target functions

Phase 3: June 2008

2GZX

44.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02289
(show subtarget assignments)

1

in_pdb
3OF5

FTT0934c

56708031

bioD

dethiobiotin synthetase [Francisella tul...

225

Conserved; Drug target functions

Phase 3: June 2008

3OF5

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01662
(show subtarget assignments)

1

purified

lmo2583

16804621

hypothetical protein lmo2583 [Listeria m...

225

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

39.1%

Listeria monocytogenes

Regulatory functions

Other

IDP90855
(show subtarget assignments)

8

cloned

VC2461

15642457

rnc

ribonuclease III [Vibrio cholerae O1 bio...

225

Predicted Essential

Community Requests

2A11

43.3%

Vibrio cholerae

IDP01520
(show subtarget assignments)

1

expressed

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00705
(show subtarget assignments)

1

cloned

SACOL0306

57285419

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

39%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP90888
(show subtarget assignments)

8

purified

Q9KQT2

22001682

RecName: Full=Cytidylate kinase; Short=C...

225

Predicted Essential

Community Requests

1CKE

70.2%

Vibrio cholerae

IDP05093
(show subtarget assignments)

1

cloned

lmo0193

16802239

-

hypothetical protein lmo0193 [Listeria m...

225

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FPP

22.7%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP90195
(show subtarget assignments)

8

soluble

AAM13642.1

20153181

CPXV203 CDS

CPXV203 protein

225

ER-localized, MHC-I inhibitor

Community Requests

Cowpox virus

host defense modulator

0

IDP01198
(show subtarget assignments)

1

purified

BA_1518

59798071

Cytidylate kinase (CK) (Cytidine monopho...

225

Conserved Gene / Pathway

Phase 2: March 2008

1Q3T

53.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP05763
(show subtarget assignments)

1

cloned

lmo2331

16804370

-

hypothetical protein lmo2331 [Listeria m...

226

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05298
(show subtarget assignments)

1

purified

CD2189

126699805

pgmB

beta-phosphoglucomutase [Clostridium dif...

226

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3NAS

46.9%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91880
(show subtarget assignments)

8

selected

NP_464280

16802795

hypothetical protein lmo0753 [Listeria m...

226

essential/virulence/pathogenesis / lmo0753 (681-nt, 226-aa) is one of the few Crp/Fnr family transcription factors ...

Community Requests

3D0S

21.2%

Listeria monocytogenes

IDP91757
(show subtarget assignments)

8

selected

VF01_VACCW

0

226

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2VTY

73%

Vaccinia virus

IDP02231
(show subtarget assignments)

1

purified

lmo1377

16803417

lisR

two-component response regulator [Lister...

226

Known virulence-Regulation; Predicted virulence-Resistance to antibiotics and to...

Phase 3: June 2008

1KGS

41.4%

Listeria monocytogenes

Regulatory functions

Other

IDP05645
(show subtarget assignments)

1

cloned

CD3297

126700916

hypothetical protein CD3297 [Clostridium...

226

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP00831
(show subtarget assignments)

0

work_stopped

SACOL2545

57285227

sdaAB

L-serine dehydratase, iron-sulfur-depend...

226

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP02631
(show subtarget assignments)

1

expressed

GBAA1440

47526715

cysH

phosphoadenosine phosphosulfate reductas...

226

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GOY

37.6%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP02564
(show subtarget assignments)

1

purified

GBAA0084

47525340

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

226

Conserved; Drug target functions

Phase 3: June 2008

1W77

36.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01162
(show subtarget assignments)

1

expressed

BA_5496

30259957

ABC transporter, ATP-binding protein

226

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

54.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP04524
(show subtarget assignments)

1

in_pdb
3Q58

STM1129_1_226

16764486

N-acetylmannosamine-6-phosphate 2-epimer...

226

Salmonella essential protein

Phase 4: April 2009

3Q58

100%

Salmonella enterica

IDP02025
(show subtarget assignments)

1

cloned

lmo0394

16802439

hypothetical protein lmo0394 [Listeria m...

227

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2XIV

19.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP92025
(show subtarget assignments)

8

selected

TGME49_016130

237843251

ubiquitin-conjugating enzyme E2, putativ...

227

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii