Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02129 (show subtarget assignments)	1	expressed	CBU_0450	29541057	ffh	signal recognition particle protein [Cox...	461	Conserved; Drug target functions	Phase 3: June 2008	2XXA	57.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02130 (show subtarget assignments)	1	cloned	Cj1416c	15792734		putative sugar nucleotidyltransferase [C...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	25.7%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02131 (show subtarget assignments)	1	purified	Cj1419c	15792737		methyltransferase [Campylobacter jejuni ...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1VE3	18.2%	Campylobacter jejuni	Cell envelope	Other

IDP02132 (show subtarget assignments)	1	cloned	GBAA1892	47527187	dra	deoxyribose-phosphate aldolase [Bacillus...	223	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NGJ	57.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02133 (show subtarget assignments)	1	expressed	YPO0054	16120407	kdtX	lipopolysaccharide core biosynthesis gly...	260	Drug target motif; Involved in virulence; Drug target functions	Phase 3: June 2008	3E25	11.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02134 (show subtarget assignments)	1	soluble	CBU_0597	29541198		oxygen-independent coproporphyrinogen II...	375	Conserved; Drug target functions	Phase 3: June 2008	1OLT	20.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02135 (show subtarget assignments)	1	in_pdb 3S81 3S7Z	STM4510	16767754		putative aspartate racemase [Salmonella ...	244	Conserved; Drug target functions	Phase 3: June 2008	3S7Z	100%	Salmonella enterica	Unknown function	General

IDP02136 (show subtarget assignments)	1	purified	YPO0114	16120460	metJ	transcriptional repressor protein MetJ [...	105	Involved in virulence; Drug target functions	Phase 3: June 2008	1CMA	88.6%	Yersinia pestis	Regulatory functions	DNA interactions

IDP02137 (show subtarget assignments)	1	soluble	Cj0547	15791908	flaG	flagellar protein FlaG [Campylobacter je...	121	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02138 (show subtarget assignments)	1	expressed	Cj0580c	15791940		coproporphyrinogen III oxidase [Campylob...	355	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1OLT	22.5%	Campylobacter jejuni	Amino acid biosynthesis	Pyruvate family

IDP02139 (show subtarget assignments)	1	crystallized	GBAA4009	47529302	gmk	guanylate kinase [Bacillus anthracis str...	205	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TAU	63.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02140 (show subtarget assignments)	1	cloned	YPO1629	16121897		N-acetyl-D-glucosamine kinase [Yersinia ...	256	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2AP1	60.2%	Yersinia pestis	Unknown function	General

IDP02141 (show subtarget assignments)	1	purified	CBU_0737	29541337	tig	trigger factor [Coxiella burnetii RSA 49...	442	Conserved; Drug target functions	Phase 3: June 2008	1W26	41%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02142 (show subtarget assignments)	1	cloned	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP02143 (show subtarget assignments)	1	expressed	CBU_0739	29541339	clpX	ATP-dependent Clp protease, ATP-binding ...	422	Conserved; Drug target functions	Phase 3: June 2008	3HTE	59.5%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02144 (show subtarget assignments)	1	cloned	FTT1136c	56708211		hypothetical protein FTT1136c [Francisel...	111	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02145 (show subtarget assignments)	1	cloned	YPO1301	16121583	psaE	putative regulatory protein [Yersinia pe...	214	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP02146 (show subtarget assignments)	1	cloned	Cj1426c	15792744		hypothetical protein Cj1426c [Campylobac...	283	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP02147 (show subtarget assignments)	1	cloned	YPO0134	16120477		hypothetical protein YPO0134 [Yersinia p...	791	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2OCE	61.4%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02148 (show subtarget assignments)	1	cloned	GBAA0133	47525389	infA	translation initiation factor IF-1 [Baci...	72	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AH9	72.2%	Bacillus anthracis	Protein synthesis	Translation factors

IDP02149 (show subtarget assignments)	1	cloned	Cj1428c	15792746	fcl	putative fucose synthetase [Campylobacte...	346	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1BSV	38.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02150 (show subtarget assignments)	1	cloned	lmo1104	16803144		hypothetical protein lmo1104 [Listeria m...	336	Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...	Phase 3: June 2008	2EVR	15.5%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02151 (show subtarget assignments)	1	cloned	GBAA3159	47528451		hypothetical protein GBAA3159 [Bacillus ...	175	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Hypothetical proteins	Conserved

IDP02152 (show subtarget assignments)	1	soluble	FTT0955c	56708049	gor	glutathione reductase [Francisella tular...	453	Conserved; Drug target functions	Phase 3: June 2008	1GER	49.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02153 (show subtarget assignments)	1	expressed	CBU_0884	29541475	bipA	virulence regulator BipA [Coxiella burne...	602	Conserved; Drug target functions	Phase 3: June 2008	3E3X	34.6%	Coxiella burnetii	Cellular processes	Pathogenesis

IDP02154 (show subtarget assignments)	1	expressed	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02155 (show subtarget assignments)	1	purified	YPO0239	16120577	trkA	potassium transporter peripheral membran...	458	Conserved; CD; Drug target functions	Phase 3: June 2008	1LSS	12.2%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02156 (show subtarget assignments)	1	soluble	YPO0253	16120590	acs	acetyl-CoA synthetase [Yersinia pestis C...	652	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2P2F	83.9%	Yersinia pestis	Central intermediary metabolism	Other

IDP02157 (show subtarget assignments)	1	expressed	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02158 (show subtarget assignments)	1	cloned	Cj1617	15792922	chuD	putative haemin uptake system periplasmi...	268	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3GFV	27%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP02159 (show subtarget assignments)	1	cloned	CBU_1892	29542449	aroK	shikimate kinase [Coxiella burnetii RSA ...	179	Conserved; Drug target functions	Phase 3: June 2008	3TRF	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02160 (show subtarget assignments)	1	soluble	CBU_1245	29541815		GTP-binding protein [Coxiella burnetii R...	443	Conserved; Drug target functions	Phase 3: June 2008	2HJG	38.4%	Coxiella burnetii	Unknown function	General

IDP02161 (show subtarget assignments)	1	soluble	FTT0162	56707332	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	174	Drug Target	Phase 3: June 2008	1J3G	47.7%	Francisella tularensis	Cellular processes	Toxin production and resistance

IDP02162 (show subtarget assignments)	1	cloned	FTT1463c	56708504	wbtB	galactosyl transferase [Francisella tula...	205	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02163 (show subtarget assignments)	1	cloned	GBAA3914	47529205		phosphodiesterase [Bacillus anthracis st...	520	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	General

IDP02164 (show subtarget assignments)	1	in_pdb 3I3W	FTT0079	56707258	mrsA	phosphoglucosamine mutase [Francisella t...	443	Conserved; Drug target functions	Phase 3: June 2008	3I3W	100%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02165 (show subtarget assignments)	1	soluble	CBU_1993	29542548	folA	dihydrofolate reductase [Coxiella burnet...	161	Conserved; Drug target functions	Phase 3: June 2008	3TQ8	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02166 (show subtarget assignments)	1	cloned	FTT0188	56707353	ftsZ	cell division protein FtsZ [Francisella ...	381	Conserved; Drug target functions	Phase 3: June 2008	2VAW	55.9%	Francisella tularensis	Cellular processes	Cell division

IDP02167 (show subtarget assignments)	1	expressed	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02168 (show subtarget assignments)	1	expressed	CBU_1289	29541857	dnaJ	chaperone protein dnaJ [Coxiella burneti...	374	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	32.1%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02169 (show subtarget assignments)	1	soluble	FTT0306	56707459	fumC	fumarate hydratase [Francisella tularens...	463	Conserved; Drug target functions	Phase 3: June 2008	3E04	55.3%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02170 (show subtarget assignments)	1	soluble	FTT1010	56708100		helix-turn-helix family protein [Francis...	67	Drug Target	Phase 3: June 2008	3T75	29.9%	Francisella tularensis	Unknown function	General

IDP02171 (show subtarget assignments)	1	soluble	CBU_0894	29541483	folC	FolC bifunctional protein [Coxiella burn...	416	Conserved; Drug target functions	Phase 3: June 2008	1W78	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02172 (show subtarget assignments)	1	cloned	YPO0893	16121198	fldB	flavodoxin FldB [Yersinia pestis CO92]	172	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1FLV	46.5%	Yersinia pestis	Energy metabolism	Electron transport

IDP02173 (show subtarget assignments)	1	expressed	Cj1136	15792461		putative galactosyltransferase [Campylob...	390	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	20.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02174 (show subtarget assignments)	1	cloned	YPO3031	16123208		putative acetyltransferase [Yersinia pes...	141	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2PDO	78%	Yersinia pestis	Central intermediary metabolism	Other

IDP02175 (show subtarget assignments)	1	cloned	YPO3064	16123241	bcp	thioredoxin-dependent thiol peroxidase [...	157	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3DRN	36.9%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02176 (show subtarget assignments)	1	purified	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP02177 (show subtarget assignments)	1	soluble	FTT0063	56707242	atpG	F0F1 ATP synthase subunit gamma [Francis...	298	Conserved; Drug target functions	Phase 3: June 2008	3OAA	49.7%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02178 (show subtarget assignments)	1	soluble	FTT0032	56707212	nuoB	NADH dehydrogenase subunit B [Francisell...	158	Drug Target	Phase 3: June 2008	2FUG	53.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP02179 (show subtarget assignments)	1	soluble	CBU_2090	29542640	proC	pyrroline-5-carboxylate reductase [Coxie...	274	Conserved; Drug target functions	Phase 3: June 2008	3TRI	100%	Coxiella burnetii	Amino acid biosynthesis	Glutamate family

IDP02180 (show subtarget assignments)	1	cloned	Cj0299	15791667		putative periplasmic beta-lactamase [Cam...	257	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	1E3U	34.6%	Campylobacter jejuni	Transport and binding proteins	Anions

IDP02181 (show subtarget assignments)	1	cloned	YPO0256	16120593		two-component sensor/regulator [Yersinia...	939	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2C2A	8%	Yersinia pestis	Regulatory functions	Other

IDP02182 (show subtarget assignments)	1	cloned	FTT0065	56707244	atpC	F0F1 ATP synthase subunit epsilon [Franc...	145	Conserved; Drug target functions	Phase 3: June 2008	2QE7	33.1%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02183 (show subtarget assignments)	1	purified	FTT0414	56707563	pgm	phosphoglucomutase [Francisella tularens...	544	Drug Target	Phase 3: June 2008	1C47	54.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02184 (show subtarget assignments)	1	expressed	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP02185 (show subtarget assignments)	1	selected	FTT0408	56707557	gcvH	glycine cleavage system H protein [Franc...	127	Drug Target	Phase 3: June 2008	3A7A	59.8%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02186 (show subtarget assignments)	1	soluble	FTT1672	56708682	ribB	riboflavin synthase subunit alpha [Franc...	201	Conserved; Drug target functions	Phase 3: June 2008	1KZL	35.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02187 (show subtarget assignments)	1	purified	FTT0504c	56707643	sucC	succinyl-CoA synthetase subunit beta [Fr...	387	Conserved; Drug target functions	Phase 3: June 2008	1CQI	62.8%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02188 (show subtarget assignments)	1	expressed	YPO0267	16120605		type III secretion system ATPase [Yersin...	445	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008	2DPY	43.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02189 (show subtarget assignments)	1	cloned	YPO0269	16120608		type III secretion system protein [Yersi...	306	Conserved; Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02190 (show subtarget assignments)	1	expressed	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP02191 (show subtarget assignments)	1	expressed	FTT0878c	56707982	msrB	methionine sulfoxide reductase B [Franci...	170	Drug Target	Phase 3: June 2008	1XM0	47.6%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP02192 (show subtarget assignments)	1	soluble	YPO0348	16120683	aspA	aspartate ammonia-lyase [Yersinia pestis...	478	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1JSW	89.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02193 (show subtarget assignments)	1	purified	FTT0868c	56707972		arsenical restistance operon repressor [...	121	Drug Target	Phase 3: June 2008	3JTH	22.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02194 (show subtarget assignments)	1	expressed	FTT0075	56707254	sdhB	succinate dehydrogenase iron-sulfur subu...	233	Conserved; Drug target functions	Phase 3: June 2008	1NEK	66.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02195 (show subtarget assignments)	1	expressed	FTT0084c	56707262	hemN	oxygen-independent coproporphyrinogen II...	380	Conserved; Drug target functions	Phase 3: June 2008	1OLT	22.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02196 (show subtarget assignments)	1	purified	GBAA0734	47526018	thiD-1	phosphomethylpyrimidine kinase [Bacillus...	270	Conserved; Drug target functions	Phase 3: June 2008	2I5B	48.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02197 (show subtarget assignments)	1	cloned	YPO0405	16120739		putative phosphoenolpyruvate-protein pho...	852	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2KX9	24.6%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02198 (show subtarget assignments)	1	cloned	YPO1273	16121558		putative substrate-binding transport pro...	602	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1XOC	21.6%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02199 (show subtarget assignments)	1	expressed	CBU_1505	29542064	lepA	GTP-binding protein LepA [Coxiella burne...	614	Conserved; Drug target functions	Phase 3: June 2008	3CB4	69.9%	Coxiella burnetii	Unknown function	General

IDP02200 (show subtarget assignments)	1	cloned	CBU_1103	29541677		transglycosylase, Slt family [Coxiella b...	425	Conserved; Drug target functions	Phase 3: June 2008	1QSA	16.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02201 (show subtarget assignments)	1	soluble	YPO0461	16120790	thrC	threonine synthase [Yersinia pestis CO92...	429	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1VB3	82.3%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02202 (show subtarget assignments)	1	purified	FTT0774	56707886		hypothetical protein FTT0774 [Francisell...	125	Drug Target	Phase 3: June 2008	3USH	52.8%	Francisella tularensis	Unknown function	General

IDP02203 (show subtarget assignments)	1	purified	YPO0442	16120773	serB	phosphoserine phosphatase [Yersinia pest...	326	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3N28	46.3%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP02204 (show subtarget assignments)	1	cloned	Cj1462	6968880	Cj1452	putative integral membrane protein [Camp...	237	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP02205 (show subtarget assignments)	1	purified	FTT0259	56707415	hemC	hydroxymethylbilane synthase (porphobili...	300	Conserved; Drug target functions	Phase 3: June 2008	1AH5	54.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02206 (show subtarget assignments)	1	soluble	lmo0065	16802113		hypothetical protein lmo0065 [Listeria m...	110	Predicted virulence-Type III; Type IV; ESAT secretion systems	Phase 3: June 2008			Listeria monocytogenes	Cellular processes	Pathogenesis

IDP02207 (show subtarget assignments)	1	expressed	YPO0612	16120938		putative sugar binding protein [Yersinia...	414	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QUF	24.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02208 (show subtarget assignments)	1	cloned	FTT0964c	56708058	ffh	signal recognition particle protein, Ffh...	458	Conserved; Drug target functions	Phase 3: June 2008	2XXA	59%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02209 (show subtarget assignments)	1	cloned	Cj1337	15792660		hypothetical protein Cj1337 [Campylobact...	628	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02210 (show subtarget assignments)	1	cloned	FTT0980	56708072		hypothetical protein FTT0980 [Francisell...	413	Conserved; Drug target functions	Phase 3: June 2008	1FC4	26.4%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP02211 (show subtarget assignments)	1	cloned	CBU_2025	29542578	metC	cystathionine beta-lyase [Coxiella burne...	387	Conserved; Drug target functions	Phase 3: June 2008	3E6G	63%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02212 (show subtarget assignments)	1	cloned	CBU_2048	29542599	metE	5-methyltetrahydropteroyltriglutamate--h...	775	Conserved; Drug target functions	Phase 3: June 2008	1U1H	48.5%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02213 (show subtarget assignments)	1	expressed	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02214 (show subtarget assignments)	1	soluble	Cj0041	15791440		hypothetical protein Cj0041 [Campylobact...	598	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02215 (show subtarget assignments)	1	cloned	Cj0077c	15791467	cdtC	cytolethal distending toxin [Campylobact...	189	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02216 (show subtarget assignments)	1	cloned	GBAA1449	47526724		M23/37 family peptidase [Bacillus anthra...	417	Drug target motif; Conserved; Involved in sporulation; Vaccine Target; Drug targ...	Phase 3: June 2008	2HSI	15.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02217 (show subtarget assignments)	1	expressed	FTT1018c	56708107	dxs	1-deoxy-D-xylulose-5-phosphate synthase ...	615	Conserved; Drug target functions	Phase 3: June 2008	2O1S	56.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	OtherPyridoxine,Thiamine

IDP02218 (show subtarget assignments)	1	expressed	GBAA2133	47778008	narA-1	molybdenum cofactor biosynthesis protein...	337	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TV7	54.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02219 (show subtarget assignments)	1	purified	FTT1019c	56708108	guaA	bifunctional GMP synthase/glutamine amid...	516	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1GPM	61.1%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02220 (show subtarget assignments)	1	cloned	YPO2221	16122450	acnA	aconitate hydratase [Yersinia pestis CO9...	890	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	3SN2	52.2%	Yersinia pestis	Energy metabolism	TCA cycle

IDP02221 (show subtarget assignments)	1	cloned	Cj1421c	15792739		sugar transferase [Campylobacter jejuni ...	612	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02222 (show subtarget assignments)	1	crystallized	lmo0484	16802527		heme-degrading monooxygenase IsdG [Liste...	121	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1TZ0	28.9%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP02223 (show subtarget assignments)	1	expressed	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02224 (show subtarget assignments)	1	cloned	YPO0616	16120942		putative glycosyl hydrolase [Yersinia pe...	727	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	2X40	26.5%	Yersinia pestis	Energy metabolism	Sugars

IDP02225 (show subtarget assignments)	1	cloned	CBU_1338	29541903		D-alanine--D-alanine ligase [Coxiella bu...	372	Conserved; Drug target functions	Phase 3: June 2008	3TQT	100%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02226 (show subtarget assignments)	1	crystallized	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP02227 (show subtarget assignments)	1	cloned	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02228 (show subtarget assignments)	1	cloned	FTT1240c	56708302		hypothetical protein FTT1240c [Francisel...	182	Drug Target	Phase 3: June 2008	2P0T	32.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02129
(show subtarget assignments)

1

expressed

CBU_0450

29541057

ffh

signal recognition particle protein [Cox...

461

Conserved; Drug target functions

Phase 3: June 2008

2XXA

57.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02130
(show subtarget assignments)

1

cloned

Cj1416c

15792734

putative sugar nucleotidyltransferase [C...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

25.7%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02131
(show subtarget assignments)

1

purified

Cj1419c

15792737

methyltransferase [Campylobacter jejuni ...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1VE3

18.2%

Campylobacter jejuni

Cell envelope

Other

IDP02132
(show subtarget assignments)

1

cloned

GBAA1892

47527187

dra

deoxyribose-phosphate aldolase [Bacillus...

223

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NGJ

57.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02133
(show subtarget assignments)

1

expressed

YPO0054

16120407

kdtX

lipopolysaccharide core biosynthesis gly...

260

Drug target motif; Involved in virulence; Drug target functions

Phase 3: June 2008

3E25

11.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02134
(show subtarget assignments)

1

soluble

CBU_0597

29541198

oxygen-independent coproporphyrinogen II...

375

Conserved; Drug target functions

Phase 3: June 2008

1OLT

20.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02135
(show subtarget assignments)

1

in_pdb
3S81
3S7Z

STM4510

16767754

putative aspartate racemase [Salmonella ...

244

Conserved; Drug target functions

Phase 3: June 2008

3S7Z

100%

Salmonella enterica

Unknown function

General

IDP02136
(show subtarget assignments)

1

purified

YPO0114

16120460

metJ

transcriptional repressor protein MetJ [...

105

Involved in virulence; Drug target functions

Phase 3: June 2008

1CMA

88.6%

Yersinia pestis

Regulatory functions

DNA interactions

IDP02137
(show subtarget assignments)

1

soluble

Cj0547

15791908

flaG

flagellar protein FlaG [Campylobacter je...

121

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02138
(show subtarget assignments)

1

expressed

Cj0580c

15791940

coproporphyrinogen III oxidase [Campylob...

355

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1OLT

22.5%

Campylobacter jejuni

Amino acid biosynthesis

Pyruvate family

IDP02139
(show subtarget assignments)

1

crystallized

GBAA4009

47529302

gmk

guanylate kinase [Bacillus anthracis str...

205

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TAU

63.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02140
(show subtarget assignments)

1

cloned

YPO1629

16121897

N-acetyl-D-glucosamine kinase [Yersinia ...

256

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2AP1

60.2%

Yersinia pestis

Unknown function

General

IDP02141
(show subtarget assignments)

1

purified

CBU_0737

29541337

tig

trigger factor [Coxiella burnetii RSA 49...

442

Conserved; Drug target functions

Phase 3: June 2008

1W26

41%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02142
(show subtarget assignments)

1

cloned

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP02143
(show subtarget assignments)

1

expressed

CBU_0739

29541339

clpX

ATP-dependent Clp protease, ATP-binding ...

422

Conserved; Drug target functions

Phase 3: June 2008

3HTE

59.5%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02144
(show subtarget assignments)

1

cloned

FTT1136c

56708211

hypothetical protein FTT1136c [Francisel...

111

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02145
(show subtarget assignments)

1

cloned

YPO1301

16121583

psaE

putative regulatory protein [Yersinia pe...

214

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP02146
(show subtarget assignments)

1

cloned

Cj1426c

15792744

hypothetical protein Cj1426c [Campylobac...

283

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP02147
(show subtarget assignments)

1

cloned

YPO0134

16120477

hypothetical protein YPO0134 [Yersinia p...

791

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2OCE

61.4%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02148
(show subtarget assignments)

1

cloned

GBAA0133

47525389

infA

translation initiation factor IF-1 [Baci...

72

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AH9

72.2%

Bacillus anthracis

Protein synthesis

Translation factors

IDP02149
(show subtarget assignments)

1

cloned

Cj1428c

15792746

fcl

putative fucose synthetase [Campylobacte...

346

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1BSV

38.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02150
(show subtarget assignments)

1

cloned

lmo1104

16803144

hypothetical protein lmo1104 [Listeria m...

336

Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...

Phase 3: June 2008

2EVR

15.5%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP02151
(show subtarget assignments)

1

cloned

GBAA3159

47528451

hypothetical protein GBAA3159 [Bacillus ...

175

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02152
(show subtarget assignments)

1

soluble

FTT0955c

56708049

gor

glutathione reductase [Francisella tular...

453

Conserved; Drug target functions

Phase 3: June 2008

1GER

49.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02153
(show subtarget assignments)

1

expressed

CBU_0884

29541475

bipA

virulence regulator BipA [Coxiella burne...

602

Conserved; Drug target functions

Phase 3: June 2008

3E3X

34.6%

Coxiella burnetii

Cellular processes

Pathogenesis

IDP02154
(show subtarget assignments)

1

expressed

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02155
(show subtarget assignments)

1

purified

YPO0239

16120577

trkA

potassium transporter peripheral membran...

458

Conserved; CD; Drug target functions

Phase 3: June 2008

1LSS

12.2%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02156
(show subtarget assignments)

1

soluble

YPO0253

16120590

acs

acetyl-CoA synthetase [Yersinia pestis C...

652

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2P2F

83.9%

Yersinia pestis

Central intermediary metabolism

Other

IDP02157
(show subtarget assignments)

1

expressed

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02158
(show subtarget assignments)

1

cloned

Cj1617

15792922

chuD

putative haemin uptake system periplasmi...

268

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3GFV

27%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP02159
(show subtarget assignments)

1

cloned

CBU_1892

29542449

aroK

shikimate kinase [Coxiella burnetii RSA ...

179

Conserved; Drug target functions

Phase 3: June 2008

3TRF

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02160
(show subtarget assignments)

1

soluble

CBU_1245

29541815

GTP-binding protein [Coxiella burnetii R...

443

Conserved; Drug target functions

Phase 3: June 2008

2HJG

38.4%

Coxiella burnetii

Unknown function

General

IDP02161
(show subtarget assignments)

1

soluble

FTT0162

56707332

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

174

Drug Target

Phase 3: June 2008

1J3G

47.7%

Francisella tularensis

Cellular processes

Toxin production and resistance

IDP02162
(show subtarget assignments)

1

cloned

FTT1463c

56708504

wbtB

galactosyl transferase [Francisella tula...

205

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02163
(show subtarget assignments)

1

cloned

GBAA3914

47529205

phosphodiesterase [Bacillus anthracis st...

520

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

General

IDP02164
(show subtarget assignments)

1

in_pdb
3I3W

FTT0079

56707258

mrsA

phosphoglucosamine mutase [Francisella t...

443

Conserved; Drug target functions

Phase 3: June 2008

3I3W

100%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02165
(show subtarget assignments)

1

soluble

CBU_1993

29542548

folA

dihydrofolate reductase [Coxiella burnet...

161

Conserved; Drug target functions

Phase 3: June 2008

3TQ8

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02166
(show subtarget assignments)

1

cloned

FTT0188

56707353

ftsZ

cell division protein FtsZ [Francisella ...

381

Conserved; Drug target functions

Phase 3: June 2008

2VAW

55.9%

Francisella tularensis

Cellular processes

Cell division

IDP02167
(show subtarget assignments)

1

expressed

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02168
(show subtarget assignments)

1

expressed

CBU_1289

29541857

dnaJ

chaperone protein dnaJ [Coxiella burneti...

374

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

32.1%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02169
(show subtarget assignments)

1

soluble

FTT0306

56707459

fumC

fumarate hydratase [Francisella tularens...

463

Conserved; Drug target functions

Phase 3: June 2008

3E04

55.3%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02170
(show subtarget assignments)

1

soluble

FTT1010

56708100

helix-turn-helix family protein [Francis...

67

Drug Target

Phase 3: June 2008

3T75

29.9%

Francisella tularensis

Unknown function

General

IDP02171
(show subtarget assignments)

1

soluble

CBU_0894

29541483

folC

FolC bifunctional protein [Coxiella burn...

416

Conserved; Drug target functions

Phase 3: June 2008

1W78

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02172
(show subtarget assignments)

1

cloned

YPO0893

16121198

fldB

flavodoxin FldB [Yersinia pestis CO92]

172

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1FLV

46.5%

Yersinia pestis

Energy metabolism

Electron transport

IDP02173
(show subtarget assignments)

1

expressed

Cj1136

15792461

putative galactosyltransferase [Campylob...

390

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

20.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02174
(show subtarget assignments)

1

cloned

YPO3031

16123208

putative acetyltransferase [Yersinia pes...

141

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2PDO

78%

Yersinia pestis

Central intermediary metabolism

Other

IDP02175
(show subtarget assignments)

1

cloned

YPO3064

16123241

bcp

thioredoxin-dependent thiol peroxidase [...

157

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3DRN

36.9%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02176
(show subtarget assignments)

1

purified

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP02177
(show subtarget assignments)

1

soluble

FTT0063

56707242

atpG

F0F1 ATP synthase subunit gamma [Francis...

298

Conserved; Drug target functions

Phase 3: June 2008

3OAA

49.7%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02178
(show subtarget assignments)

1

soluble

FTT0032

56707212

nuoB

NADH dehydrogenase subunit B [Francisell...

158

Drug Target

Phase 3: June 2008

2FUG

53.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP02179
(show subtarget assignments)

1

soluble

CBU_2090

29542640

proC

pyrroline-5-carboxylate reductase [Coxie...

274

Conserved; Drug target functions

Phase 3: June 2008

3TRI

100%

Coxiella burnetii

Amino acid biosynthesis

Glutamate family

IDP02180
(show subtarget assignments)

1

cloned

Cj0299

15791667

putative periplasmic beta-lactamase [Cam...

257

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

1E3U

34.6%

Campylobacter jejuni

Transport and binding proteins

Anions

IDP02181
(show subtarget assignments)

1

cloned

YPO0256

16120593

two-component sensor/regulator [Yersinia...

939

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2C2A

8%

Yersinia pestis

Regulatory functions

Other

IDP02182
(show subtarget assignments)

1

cloned

FTT0065

56707244

atpC

F0F1 ATP synthase subunit epsilon [Franc...

145

Conserved; Drug target functions

Phase 3: June 2008

2QE7

33.1%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02183
(show subtarget assignments)

1

purified

FTT0414

56707563

pgm

phosphoglucomutase [Francisella tularens...

544

Drug Target

Phase 3: June 2008

1C47

54.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02184
(show subtarget assignments)

1

expressed

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP02185
(show subtarget assignments)

1

selected

FTT0408

56707557

gcvH

glycine cleavage system H protein [Franc...

127

Drug Target

Phase 3: June 2008

3A7A

59.8%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02186
(show subtarget assignments)

1

soluble

FTT1672

56708682

ribB

riboflavin synthase subunit alpha [Franc...

201

Conserved; Drug target functions

Phase 3: June 2008

1KZL

35.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02187
(show subtarget assignments)

1

purified

FTT0504c

56707643

sucC

succinyl-CoA synthetase subunit beta [Fr...

387

Conserved; Drug target functions

Phase 3: June 2008

1CQI

62.8%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02188
(show subtarget assignments)

1

expressed

YPO0267

16120605

type III secretion system ATPase [Yersin...

445

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

2DPY

43.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02189
(show subtarget assignments)

1

cloned

YPO0269

16120608

type III secretion system protein [Yersi...

306

Conserved; Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02190
(show subtarget assignments)

1

expressed

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

IDP02191
(show subtarget assignments)

1

expressed

FTT0878c

56707982

msrB

methionine sulfoxide reductase B [Franci...

170

Drug Target

Phase 3: June 2008

1XM0

47.6%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP02192
(show subtarget assignments)

1

soluble

YPO0348

16120683

aspA

aspartate ammonia-lyase [Yersinia pestis...

478

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1JSW

89.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02193
(show subtarget assignments)

1

purified

FTT0868c

56707972

arsenical restistance operon repressor [...

121

Drug Target

Phase 3: June 2008

3JTH

22.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02194
(show subtarget assignments)

1

expressed

FTT0075

56707254

sdhB

succinate dehydrogenase iron-sulfur subu...

233

Conserved; Drug target functions

Phase 3: June 2008

1NEK

66.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02195
(show subtarget assignments)

1

expressed

FTT0084c

56707262

hemN

oxygen-independent coproporphyrinogen II...

380

Conserved; Drug target functions

Phase 3: June 2008

1OLT

22.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02196
(show subtarget assignments)

1

purified

GBAA0734

47526018

thiD-1

phosphomethylpyrimidine kinase [Bacillus...

270

Conserved; Drug target functions

Phase 3: June 2008

2I5B

48.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02197
(show subtarget assignments)

1

cloned

YPO0405

16120739

putative phosphoenolpyruvate-protein pho...

852

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2KX9

24.6%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02198
(show subtarget assignments)

1

cloned

YPO1273

16121558

putative substrate-binding transport pro...

602

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1XOC

21.6%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02199
(show subtarget assignments)

1

expressed

CBU_1505

29542064

lepA

GTP-binding protein LepA [Coxiella burne...

614

Conserved; Drug target functions

Phase 3: June 2008

3CB4

69.9%

Coxiella burnetii

Unknown function

General

IDP02200
(show subtarget assignments)

1

cloned

CBU_1103

29541677

transglycosylase, Slt family [Coxiella b...

425

Conserved; Drug target functions

Phase 3: June 2008

1QSA

16.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02201
(show subtarget assignments)

1

soluble

YPO0461

16120790

thrC

threonine synthase [Yersinia pestis CO92...

429

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1VB3

82.3%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02202
(show subtarget assignments)

1

purified

FTT0774

56707886

hypothetical protein FTT0774 [Francisell...

125

Drug Target

Phase 3: June 2008

3USH

52.8%

Francisella tularensis

Unknown function

General

IDP02203
(show subtarget assignments)

1

purified

YPO0442

16120773

serB

phosphoserine phosphatase [Yersinia pest...

326

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3N28

46.3%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP02204
(show subtarget assignments)

1

cloned

Cj1462

6968880

Cj1452

putative integral membrane protein [Camp...

237

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP02205
(show subtarget assignments)

1

purified

FTT0259

56707415

hemC

hydroxymethylbilane synthase (porphobili...

300

Conserved; Drug target functions

Phase 3: June 2008

1AH5

54.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02206
(show subtarget assignments)

1

soluble

lmo0065

16802113

hypothetical protein lmo0065 [Listeria m...

110

Predicted virulence-Type III; Type IV; ESAT secretion systems

Phase 3: June 2008

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP02207
(show subtarget assignments)

1

expressed

YPO0612

16120938

putative sugar binding protein [Yersinia...

414

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QUF

24.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02208
(show subtarget assignments)

1

cloned

FTT0964c

56708058

ffh

signal recognition particle protein, Ffh...

458

Conserved; Drug target functions

Phase 3: June 2008

2XXA

59%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02209
(show subtarget assignments)

1

cloned

Cj1337

15792660

hypothetical protein Cj1337 [Campylobact...

628

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02210
(show subtarget assignments)

1

cloned

FTT0980

56708072

hypothetical protein FTT0980 [Francisell...

413

Conserved; Drug target functions

Phase 3: June 2008

1FC4

26.4%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP02211
(show subtarget assignments)

1

cloned

CBU_2025

29542578

metC

cystathionine beta-lyase [Coxiella burne...

387

Conserved; Drug target functions

Phase 3: June 2008

3E6G

63%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02212
(show subtarget assignments)

1

cloned

CBU_2048

29542599

metE

5-methyltetrahydropteroyltriglutamate--h...

775

Conserved; Drug target functions

Phase 3: June 2008

1U1H

48.5%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02213
(show subtarget assignments)

1

expressed

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02214
(show subtarget assignments)

1

soluble

Cj0041

15791440

hypothetical protein Cj0041 [Campylobact...

598

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02215
(show subtarget assignments)

1

cloned

Cj0077c

15791467

cdtC

cytolethal distending toxin [Campylobact...

189

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02216
(show subtarget assignments)

1

cloned

GBAA1449

47526724

M23/37 family peptidase [Bacillus anthra...

417

Drug target motif; Conserved; Involved in sporulation; Vaccine Target; Drug targ...

Phase 3: June 2008

2HSI

15.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02217
(show subtarget assignments)

1

expressed

FTT1018c

56708107

dxs

1-deoxy-D-xylulose-5-phosphate synthase ...

615

Conserved; Drug target functions

Phase 3: June 2008

2O1S

56.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

OtherPyridoxine,Thiamine

IDP02218
(show subtarget assignments)

1

expressed

GBAA2133

47778008

narA-1

molybdenum cofactor biosynthesis protein...

337

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TV7

54.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02219
(show subtarget assignments)

1

purified

FTT1019c

56708108

guaA

bifunctional GMP synthase/glutamine amid...

516

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1GPM

61.1%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02220
(show subtarget assignments)

1

cloned

YPO2221

16122450

acnA

aconitate hydratase [Yersinia pestis CO9...

890

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

3SN2

52.2%

Yersinia pestis

Energy metabolism

TCA cycle

IDP02221
(show subtarget assignments)

1

cloned

Cj1421c

15792739

sugar transferase [Campylobacter jejuni ...

612

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02222
(show subtarget assignments)

1

crystallized

lmo0484

16802527

heme-degrading monooxygenase IsdG [Liste...

121

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1TZ0

28.9%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP02223
(show subtarget assignments)

1

expressed

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02224
(show subtarget assignments)

1

cloned

YPO0616

16120942

putative glycosyl hydrolase [Yersinia pe...

727

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

2X40

26.5%

Yersinia pestis

Energy metabolism

Sugars

IDP02225
(show subtarget assignments)

1

cloned

CBU_1338

29541903

D-alanine--D-alanine ligase [Coxiella bu...

372

Conserved; Drug target functions

Phase 3: June 2008

3TQT

100%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02226
(show subtarget assignments)

1

crystallized

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP02227
(show subtarget assignments)

1

cloned

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02228
(show subtarget assignments)

1

cloned

FTT1240c

56708302

hypothetical protein FTT1240c [Francisel...

182

Drug Target

Phase 3: June 2008

2P0T

32.4%

Francisella tularensis

Unclassified

Role category not yet assigned

Targets