Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00479 (show subtarget assignments)	1	in_pdb 3H07	YPO0658	16120983	ribB	3,4-dihydroxy-2-butanone 4-phosphate syn...	217	Conserved Gene / Pathway	Phase 2: March 2008	3H07	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00480 (show subtarget assignments)	1	soluble	YPO3118	16123283	adk	adenylate kinase	214	Conserved Gene / Pathway	Phase 2: March 2008	1AKE	87.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00481 (show subtarget assignments)	1	expressed	YPO3558	16123702	gltD	glutamate synthase subunit beta	472	Virulence Associated Factor	Phase 2: March 2008	2VDC	43.2%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00482 (show subtarget assignments)	1	purified	YPO1758	16122014	manX	PTS system, mannose-specific IIAB compon...	324	Virulence Associated Factor	Phase 2: March 2008	2JZH	45.4%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00483 (show subtarget assignments)	1	expressed	YPO1316	16121598		putative iron/ascorbate oxidoreductase f...	355	Virulence Associated Factor	Phase 2: March 2008	3OOX	25.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00484 (show subtarget assignments)	1	cloned	YPO1417	16121697		putative iron-sulfur binding protein	370	Conserved Gene / Pathway	Phase 2: March 2008	2PIA	7%	Yersinia pestis	Energy metabolism	Electron transport

IDP00485 (show subtarget assignments)	1	purified	YPO1455	16121730		putative beta-ketoacyl-[acyl-carrier-pro...	427	Drug Target Function	Phase 2: March 2008	1J3N	32.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00486 (show subtarget assignments)	1	expressed	YPO1463	16121738		putative acyl transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3RGI	47.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00487 (show subtarget assignments)	1	soluble	YPO1491	16121764		ABC transporter ATP-binding protein	531	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	24.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00488 (show subtarget assignments)	1	expressed	YPO1496	16121769		putative heme-binding protein	436	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Central intermediary metabolism	Sulfur metabolism

IDP00489 (show subtarget assignments)	1	soluble	YPO1533	16121806		putative iron-siderophore transport syst...	282	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.4%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00490 (show subtarget assignments)	1	cloned	YPO1537	16121810		putative iron-siderophore receptor	753	Conserved Gene / Pathway	Phase 2: March 2008	3EFM	36%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00491 (show subtarget assignments)	1	purified	YPO1107	16121407		heat shock protein GrpE	192	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	59.4%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP00492 (show subtarget assignments)	1	selected	YPO1559	16121830		hypothetical protein YPO1559	379	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00493 (show subtarget assignments)	1	expressed	YPO1124	16121424	tolB	translocation protein TolB	430	Conserved Gene / Pathway	Phase 2: March 2008	1C5K	84.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00494 (show subtarget assignments)	1	soluble	YPO0099	16120446		hypothetical protein YPO0099	411	Drug Target Function	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00495 (show subtarget assignments)	1	expressed	YPO1698	16121958		hypothetical protein YPO1698	185	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP00496 (show subtarget assignments)	1	cloned	YPO1699	16121959		hypothetical protein YPO1699	176	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP00497 (show subtarget assignments)	1	expressed	YPO1700	16121960		hypothetical protein YPO1700	184	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP00498 (show subtarget assignments)	1	cloned	YPO0166	16120509		putative glycosyl hydrolase	437	Drug Target Function	Phase 2: March 2008	1S6Y	52.6%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00499 (show subtarget assignments)	1	in_pdb 3IIE	YPO1048	16121348	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	398	Conserved Gene / Pathway	Phase 2: March 2008	3IIE	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00500 (show subtarget assignments)	1	purified	YPO1784	16122038		putative copper resistance protein	128	Conserved Gene / Pathway	Phase 2: March 2008	1IX2	31.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00501 (show subtarget assignments)	1	purified	YPO0922	16121227	epd	D-erythrose 4-phosphate dehydrogenase	338	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	82.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00502 (show subtarget assignments)	1	selected	YPO2045	16122284		putative hemolysin	1576	Conserved Gene / Pathway	Phase 2: March 2008	3FY3	5.6%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00503 (show subtarget assignments)	1	soluble	YPO3766	16123902	fadB	multifunctional fatty acid oxidation com...	729	Virulence Associated Factor	Phase 2: March 2008	1WDK	55.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00504 (show subtarget assignments)	1	expressed	YPO1015	16121316		hypothetical protein YPO1015	202	Drug Target Function	Phase 2: March 2008			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00505 (show subtarget assignments)	1	purified	YPO1298	16121580	fruB	fructose-specific PTS IIA/HPr components...	377	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00506 (show subtarget assignments)	1	expressed	YPO2491	16122712		putative hemolysin activator protein	562	Conserved Gene / Pathway	Phase 2: March 2008	2QDZ	21.9%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00507 (show subtarget assignments)	1	purified	YPO2511	16122732		hypothetical protein YPO2511	375	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Other

IDP00508 (show subtarget assignments)	1	expressed	YPO1315	16121597		putative hydrolase	216	Conserved Gene / Pathway	Phase 2: March 2008	3FVV	35.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00509 (show subtarget assignments)	1	in_pdb 3RY3	YPO2660	16122866		putative solute-binding protein	525	Conserved Gene / Pathway	Phase 2: March 2008	3RY3	100%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00510 (show subtarget assignments)	1	purified	YPO3572	16123716		hypothetical protein YPO3572	207	Virulence Associated Factor	Phase 2: March 2008	2QGU	30%	Yersinia pestis	Cell envelope	Other

IDP00511 (show subtarget assignments)	1	in_pdb 3RPE	YPO0670	16120995	mdaB	putative modulator of drug activity	194	Conserved Gene / Pathway	Phase 2: March 2008	3RPE	100%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00512 (show subtarget assignments)	1	cloned	YPO2244	16122472		electron transport complex protein RnfC ...	620	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Unclassified	Role category not yet assigned

IDP00513 (show subtarget assignments)	1	cloned	YPO3674	16123817		putative insecticidal toxin	1011	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00514 (show subtarget assignments)	1	selected	YPO3721	16123859		hemolysin	1635	Conserved Gene / Pathway	Phase 2: March 2008	3FY3	9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00515 (show subtarget assignments)	1	cloned	YPO3922	16124053		hemophore HasA	205	Virulence Associated Factor	Phase 2: March 2008	1B2V	29.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00516 (show subtarget assignments)	1	soluble	YPO4022	16124145		putative iron transport protein	317	Conserved Gene / Pathway	Phase 2: March 2008	3GFV	34.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00517 (show subtarget assignments)	1	soluble	YPMT1.71	16082863		hypothetical protein YPMT1.71	328	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Cell division

IDP00518 (show subtarget assignments)	1	cloned	YPO1566	16121836		putative hydrolase	280	Virulence Associated Factor	Phase 2: March 2008	3QDF	31.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00519 (show subtarget assignments)	1	cloned	YPO3446	16123594	argI	ornithine carbamoyltransferase subunit I...	335	Conserved Gene / Pathway	Phase 2: March 2008	1AKM	79.1%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00520 (show subtarget assignments)	1	in_pdb 3F6M 3FPI	YPO3360	16123510	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	162	Conserved Gene / Pathway	Phase 2: March 2008	3F6M	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00521 (show subtarget assignments)	1	purified	YPO3180	16123342	thiL	thiamine monophosphate kinase	329	Conserved Gene / Pathway	Phase 2: March 2008	3MCQ	41.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP00522 (show subtarget assignments)	1	soluble	YPO3423	16123572	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	183	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	62.3%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00523 (show subtarget assignments)	1	in_pdb 3OZH 3RJU	YPO1224	16121513	ampH	beta-lactamase/D-alanine carboxypeptidas...	388	Conserved Gene / Pathway	Phase 2: March 2008	3OZH	89.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00524 (show subtarget assignments)	1	purified	YPO0490	16120820	apaH	diadenosine tetraphosphatase	289	Conserved Gene / Pathway	Phase 2: March 2008	2DFJ	73.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00525 (show subtarget assignments)	1	cloned	YPMT1.83	16082875	caf1A	putative F1 capsule anchoring protein	833	Virulence Associated Factor	Phase 2: March 2008	3RFZ	35.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00526 (show subtarget assignments)	1	purified	YPO1351	16121631	artI	arginine-binding periplasmic protein 1 p...	243	Conserved Gene / Pathway	Phase 2: March 2008	2Y7I	52.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00527 (show subtarget assignments)	1	purified	YPO0129	16120472	bioH	putative biotin biosynthesis protein	258	Drug Target Function	Phase 2: March 2008	1M33	63.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00528 (show subtarget assignments)	1	expressed	YPO0481	16120811	carA	carbamoyl phosphate synthase small subun...	391	Drug Target Function	Phase 2: March 2008	1BXR	84.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00529 (show subtarget assignments)	1	expressed	YPO2734	16122938	ccmA	putative heme exporter protein A	218	Virulence Associated Factor	Phase 2: March 2008	1B0U	27.5%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00530 (show subtarget assignments)	1	cloned	YPO2736	16122940	ccmC	putative heme exporter protein C	245	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cellular processes	Other

IDP00531 (show subtarget assignments)	1	cloned	YPO2737	16122941	ccmD	putative heme exporter protein D	100	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cellular processes	Other

IDP00532 (show subtarget assignments)	1	soluble	YPO2390	16122613	cfa	cyclopropane fatty acyl phospholipid syn...	383	Virulence Associated Factor	Phase 2: March 2008	1TPY	25.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00533 (show subtarget assignments)	1	purified	YPO0158	16120501	cysG	siroheme synthase	470	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	70.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00534 (show subtarget assignments)	1	purified	YPO3367	16123517	cysG	siroheme synthase	472	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	52.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00535 (show subtarget assignments)	1	soluble	YPO3506	16123652	dacB	D-alanyl-D-alanine carboxypeptidase/endo...	482	Drug Target Function	Phase 2: March 2008	2EX2	77.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00536 (show subtarget assignments)	1	soluble	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00537 (show subtarget assignments)	1	purified	YPO3924	16124055	argH	argininosuccinate lyase	457	Conserved Gene / Pathway	Phase 2: March 2008	1TJ7	88.8%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP00538 (show subtarget assignments)	1	in_pdb 3GVD	YPO0070	16120421	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	3GVD	100%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP00539 (show subtarget assignments)	1	purified	YPO2751	16122955	aroC	chorismate synthase	361	Conserved Gene / Pathway	Phase 2: March 2008	1R52	45%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00540 (show subtarget assignments)	1	purified	YPO2719	16122923	era	GTP-binding protein Era	303	Conserved Gene / Pathway	Phase 2: March 2008	1EGA	83.8%	Yersinia pestis	Cellular processes	Cell division

IDP00541 (show subtarget assignments)	1	soluble	YPO1597	16121865	fabH	3-oxoacyl-(acyl carrier protein) synthas...	316	Conserved Gene / Pathway	Phase 2: March 2008	1HN9	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00542 (show subtarget assignments)	1	cloned	YPO2744	16122948	fadL	long-chain fatty acid outer membrane tra...	423	Virulence Associated Factor	Phase 2: March 2008	1T16	64%	Yersinia pestis	Cell envelope	Other

IDP00543 (show subtarget assignments)	1	soluble	YPO4057	16124173	fdoH	formate dehydrogenase-O, iron-sulfur sub...	323	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	70.9%	Yersinia pestis	Energy metabolism	Anaerobic

IDP00544 (show subtarget assignments)	1	soluble	YPO2746	16122950	fadI	3-ketoacyl-CoA thiolase	436	Virulence Associated Factor	Phase 2: March 2008	1ULQ	37.4%	Yersinia pestis	Cellular processes	Detoxification

IDP00545 (show subtarget assignments)	1	cloned	YPO2747	16122951	fadJ	multifunctional fatty acid oxidation com...	774	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	34.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00546 (show subtarget assignments)	1	expressed	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP00547 (show subtarget assignments)	1	expressed	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP00548 (show subtarget assignments)	1	cloned	YPO0549	16120877	ftsI	penicillin-binding protein 3	587	Drug Target Function	Phase 2: March 2008	3OC2	41.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00549 (show subtarget assignments)	1	soluble	YPO3814	16123948	ftsY	cell division protein	541	Conserved Gene / Pathway	Phase 2: March 2008	2YHS	63.7%	Yersinia pestis	Cellular processes	Cell division

IDP00550 (show subtarget assignments)	1	soluble	YPO3488	16123634	deaD	ATP-dependent RNA helicase DeaD	664	Virulence Associated Factor	Phase 2: March 2008	1HV8	23.3%	Yersinia pestis	Transcription	Other

IDP00551 (show subtarget assignments)	1	soluble	YPO0589	16120918	fadH	2,4-dienoyl-CoA reductase	673	Virulence Associated Factor	Phase 2: March 2008	1PS9	72.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP00552 (show subtarget assignments)	1	soluble	YPO0282	16120621	hmuS	hemin transport protein	345	Conserved Gene / Pathway	Phase 2: March 2008	2J0R	89.6%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00553 (show subtarget assignments)	1	expressed	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00554 (show subtarget assignments)	1	purified	YPO1549	16121822	hisG	ATP phosphoribosyltransferase	299	Virulence Associated Factor	Phase 2: March 2008	1H3D	88%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP00555 (show subtarget assignments)	1	purified	YPO3424	16123573	nadC	quinolinate phosphoribosyltransferase	302	Conserved Gene / Pathway	Phase 2: March 2008	1QAP	72.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00556 (show subtarget assignments)	1	cloned	YPO2686	16122891	pgm	phosphoglucomutase	547	Drug Target Function	Phase 2: March 2008	2FUV	82.4%	Yersinia pestis	Energy metabolism	Sugars

IDP00557 (show subtarget assignments)	1	purified	YPO3382	16123531	gsrA	serine endoprotease	481	Virulence Associated Factor	Phase 2: March 2008	2ZLE	71.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00558 (show subtarget assignments)	1	purified	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00559 (show subtarget assignments)	1	purified	YPO3032	16123209	hemF	coproporphyrinogen III oxidase	309	Conserved Gene / Pathway	Phase 2: March 2008	3E8J	59.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00560 (show subtarget assignments)	1	soluble	YPO3852	16123987	hemY	putative protoheme IX biogenesis protein...	406	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Unknown function	General

IDP00561 (show subtarget assignments)	0	work_stopped	YPO1046	16121346	pyrH	uridylate kinase	241	Conserved Gene / Pathway	Phase 2: March 2008	2BNE	90.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00562 (show subtarget assignments)	1	soluble	YPO2908	16123099	hmp	nitric oxide dioxygenase	396	Virulence Associated Factor	Phase 2: March 2008	1GVH	63.1%	Yersinia pestis	Energy metabolism	Electron transport

IDP00563 (show subtarget assignments)	1	soluble	YPO0283	16120622	hmuR	hemin receptor precursor	676	Conserved Gene / Pathway	Phase 2: March 2008	3FHH	66.3%	Yersinia pestis	Transport and binding proteins	Other

IDP00564 (show subtarget assignments)	1	selected	YPO1403	16121683	mukF	condesin subunit F	440	Conserved Gene / Pathway	Phase 2: March 2008	3EUH	84.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00565 (show subtarget assignments)	1	purified	YPO0281	16120620	hmuT	hemin-binding periplasmic protein	279	Conserved Gene / Pathway	Phase 2: March 2008	3MD9	91%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00566 (show subtarget assignments)	1	soluble	YPO0279	16120618	hmuV	hemin transport system ATP-binding prote...	266	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	30.5%	Yersinia pestis	Transport and binding proteins	Other

IDP00567 (show subtarget assignments)	0	work_stopped	YPO1113	16121413	kgd	alpha-ketoglutarate decarboxylase	935	Virulence Associated Factor	Phase 2: March 2008	2JGD	87.8%	Yersinia pestis	Energy metabolism	TCA cycle

IDP00568 (show subtarget assignments)	0	work_stopped	YPO0106	16120453	hslV	ATP-dependent protease peptidase subunit...	174	Conserved Gene / Pathway	Phase 2: March 2008	1E94	90.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00569 (show subtarget assignments)	1	soluble	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00570 (show subtarget assignments)	1	expressed	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP00571 (show subtarget assignments)	1	in_pdb 3GOS	YPO1041	16121341	dapD	2,3,4,5-tetrahydropyridine-2-carboxylate...	274	Virulence Associated Factor	Phase 2: March 2008	3GOS	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00572 (show subtarget assignments)	1	cloned	YPO2717	16122921	lepB	lsignal peptidase I	332	Drug Target Function	Phase 2: March 2008	1T7D	54.8%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00573 (show subtarget assignments)	1	in_pdb 3GO9	YPO3991	16124118		putative insulinase family protease	499	Drug Target Function	Phase 2: March 2008	3GO9	98.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00574 (show subtarget assignments)	1	cloned	YPO0531	16120860	leuC	isopropylmalate isomerase large subunit ...	476	Virulence Associated Factor	Phase 2: March 2008	1ACO	25%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP00575 (show subtarget assignments)	1	in_pdb 3V4Z	YPO0557	16120885	ddl	D-alanine--D-alanine ligase	306	Drug Target Function	Phase 2: March 2008	3V4Z	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00576 (show subtarget assignments)	1	cloned	YPO1398	16121678	cspB	cold shock-like protein	69	Virulence Associated Factor	Phase 2: March 2008	3I2Z	50.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP00577 (show subtarget assignments)	1	in_pdb 3OYT	YPO2757	16122961	fabB	3-oxoacyl-(acyl carrier protein) synthas...	407	Virulence Associated Factor	Phase 2: March 2008	3OYT	100%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00578 (show subtarget assignments)	1	purified	YPO3553	16123697	elbB	isoprenoid biosynthesis protein with ami...	217	Drug Target Function	Phase 2: March 2008	1OY1	63.6%	Yersinia pestis	Unknown function	General

IDP00479
(show subtarget assignments)

1

in_pdb
3H07

YPO0658

16120983

ribB

3,4-dihydroxy-2-butanone 4-phosphate syn...

217

Conserved Gene / Pathway

Phase 2: March 2008

3H07

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00480
(show subtarget assignments)

1

soluble

YPO3118

16123283

adk

adenylate kinase

214

Conserved Gene / Pathway

Phase 2: March 2008

1AKE

87.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00481
(show subtarget assignments)

1

expressed

YPO3558

16123702

gltD

glutamate synthase subunit beta

472

Virulence Associated Factor

Phase 2: March 2008

2VDC

43.2%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00482
(show subtarget assignments)

1

purified

YPO1758

16122014

manX

PTS system, mannose-specific IIAB compon...

324

Virulence Associated Factor

Phase 2: March 2008

2JZH

45.4%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00483
(show subtarget assignments)

1

expressed

YPO1316

16121598

putative iron/ascorbate oxidoreductase f...

355

Virulence Associated Factor

Phase 2: March 2008

3OOX

25.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00484
(show subtarget assignments)

1

cloned

YPO1417

16121697

putative iron-sulfur binding protein

370

Conserved Gene / Pathway

Phase 2: March 2008

2PIA

7%

Yersinia pestis

Energy metabolism

Electron transport

IDP00485
(show subtarget assignments)

1

purified

YPO1455

16121730

putative beta-ketoacyl-[acyl-carrier-pro...

427

Drug Target Function

Phase 2: March 2008

1J3N

32.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00486
(show subtarget assignments)

1

expressed

YPO1463

16121738

putative acyl transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3RGI

47.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00487
(show subtarget assignments)

1

soluble

YPO1491

16121764

ABC transporter ATP-binding protein

531

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

24.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00488
(show subtarget assignments)

1

expressed

YPO1496

16121769

putative heme-binding protein

436

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Central intermediary metabolism

Sulfur metabolism

IDP00489
(show subtarget assignments)

1

soluble

YPO1533

16121806

putative iron-siderophore transport syst...

282

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.4%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00490
(show subtarget assignments)

1

cloned

YPO1537

16121810

putative iron-siderophore receptor

753

Conserved Gene / Pathway

Phase 2: March 2008

3EFM

36%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00491
(show subtarget assignments)

1

purified

YPO1107

16121407

heat shock protein GrpE

192

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

59.4%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP00492
(show subtarget assignments)

1

selected

YPO1559

16121830

hypothetical protein YPO1559

379

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00493
(show subtarget assignments)

1

expressed

YPO1124

16121424

tolB

translocation protein TolB

430

Conserved Gene / Pathway

Phase 2: March 2008

1C5K

84.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00494
(show subtarget assignments)

1

soluble

YPO0099

16120446

hypothetical protein YPO0099

411

Drug Target Function

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00495
(show subtarget assignments)

1

expressed

YPO1698

16121958

hypothetical protein YPO1698

185

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

IDP00496
(show subtarget assignments)

1

cloned

YPO1699

16121959

hypothetical protein YPO1699

176

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

IDP00497
(show subtarget assignments)

1

expressed

YPO1700

16121960

hypothetical protein YPO1700

184

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

IDP00498
(show subtarget assignments)

1

cloned

YPO0166

16120509

putative glycosyl hydrolase

437

Drug Target Function

Phase 2: March 2008

1S6Y

52.6%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00499
(show subtarget assignments)

1

in_pdb
3IIE

YPO1048

16121348

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

398

Conserved Gene / Pathway

Phase 2: March 2008

3IIE

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00500
(show subtarget assignments)

1

purified

YPO1784

16122038

putative copper resistance protein

128

Conserved Gene / Pathway

Phase 2: March 2008

1IX2

31.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00501
(show subtarget assignments)

1

purified

YPO0922

16121227

epd

D-erythrose 4-phosphate dehydrogenase

338

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

82.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00502
(show subtarget assignments)

1

selected

YPO2045

16122284

putative hemolysin

1576

Conserved Gene / Pathway

Phase 2: March 2008

3FY3

5.6%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00503
(show subtarget assignments)

1

soluble

YPO3766

16123902

fadB

multifunctional fatty acid oxidation com...

729

Virulence Associated Factor

Phase 2: March 2008

1WDK

55.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00504
(show subtarget assignments)

1

expressed

YPO1015

16121316

hypothetical protein YPO1015

202

Drug Target Function

Phase 2: March 2008

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00505
(show subtarget assignments)

1

purified

YPO1298

16121580

fruB

fructose-specific PTS IIA/HPr components...

377

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00506
(show subtarget assignments)

1

expressed

YPO2491

16122712

putative hemolysin activator protein

562

Conserved Gene / Pathway

Phase 2: March 2008

2QDZ

21.9%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00507
(show subtarget assignments)

1

purified

YPO2511

16122732

hypothetical protein YPO2511

375

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Other

IDP00508
(show subtarget assignments)

1

expressed

YPO1315

16121597

putative hydrolase

216

Conserved Gene / Pathway

Phase 2: March 2008

3FVV

35.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00509
(show subtarget assignments)

1

in_pdb
3RY3

YPO2660

16122866

putative solute-binding protein

525

Conserved Gene / Pathway

Phase 2: March 2008

3RY3

100%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00510
(show subtarget assignments)

1

purified

YPO3572

16123716

hypothetical protein YPO3572

207

Virulence Associated Factor

Phase 2: March 2008

2QGU

30%

Yersinia pestis

Cell envelope

Other

IDP00511
(show subtarget assignments)

1

in_pdb
3RPE

YPO0670

16120995

mdaB

putative modulator of drug activity

194

Conserved Gene / Pathway

Phase 2: March 2008

3RPE

100%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00512
(show subtarget assignments)

1

cloned

YPO2244

16122472

electron transport complex protein RnfC ...

620

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00513
(show subtarget assignments)

1

cloned

YPO3674

16123817

putative insecticidal toxin

1011

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00514
(show subtarget assignments)

1

selected

YPO3721

16123859

hemolysin

1635

Conserved Gene / Pathway

Phase 2: March 2008

3FY3

9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00515
(show subtarget assignments)

1

cloned

YPO3922

16124053

hemophore HasA

205

Virulence Associated Factor

Phase 2: March 2008

1B2V

29.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00516
(show subtarget assignments)

1

soluble

YPO4022

16124145

putative iron transport protein

317

Conserved Gene / Pathway

Phase 2: March 2008

3GFV

34.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00517
(show subtarget assignments)

1

soluble

YPMT1.71

16082863

hypothetical protein YPMT1.71

328

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Cell division

IDP00518
(show subtarget assignments)

1

cloned

YPO1566

16121836

putative hydrolase

280

Virulence Associated Factor

Phase 2: March 2008

3QDF

31.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00519
(show subtarget assignments)

1

cloned

YPO3446

16123594

argI

ornithine carbamoyltransferase subunit I...

335

Conserved Gene / Pathway

Phase 2: March 2008

1AKM

79.1%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00520
(show subtarget assignments)

1

in_pdb
3F6M
3FPI

YPO3360

16123510

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

162

Conserved Gene / Pathway

Phase 2: March 2008

3F6M

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00521
(show subtarget assignments)

1

purified

YPO3180

16123342

thiL

thiamine monophosphate kinase

329

Conserved Gene / Pathway

Phase 2: March 2008

3MCQ

41.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP00522
(show subtarget assignments)

1

soluble

YPO3423

16123572

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

183

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

62.3%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00523
(show subtarget assignments)

1

in_pdb
3OZH
3RJU

YPO1224

16121513

ampH

beta-lactamase/D-alanine carboxypeptidas...

388

Conserved Gene / Pathway

Phase 2: March 2008

3OZH

89.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00524
(show subtarget assignments)

1

purified

YPO0490

16120820

apaH

diadenosine tetraphosphatase

289

Conserved Gene / Pathway

Phase 2: March 2008

2DFJ

73.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00525
(show subtarget assignments)

1

cloned

YPMT1.83

16082875

caf1A

putative F1 capsule anchoring protein

833

Virulence Associated Factor

Phase 2: March 2008

3RFZ

35.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00526
(show subtarget assignments)

1

purified

YPO1351

16121631

artI

arginine-binding periplasmic protein 1 p...

243

Conserved Gene / Pathway

Phase 2: March 2008

2Y7I

52.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00527
(show subtarget assignments)

1

purified

YPO0129

16120472

bioH

putative biotin biosynthesis protein

258

Drug Target Function

Phase 2: March 2008

1M33

63.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00528
(show subtarget assignments)

1

expressed

YPO0481

16120811

carA

carbamoyl phosphate synthase small subun...

391

Drug Target Function

Phase 2: March 2008

1BXR

84.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00529
(show subtarget assignments)

1

expressed

YPO2734

16122938

ccmA

putative heme exporter protein A

218

Virulence Associated Factor

Phase 2: March 2008

1B0U

27.5%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00530
(show subtarget assignments)

1

cloned

YPO2736

16122940

ccmC

putative heme exporter protein C

245

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cellular processes

Other

IDP00531
(show subtarget assignments)

1

cloned

YPO2737

16122941

ccmD

putative heme exporter protein D

100

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cellular processes

Other

IDP00532
(show subtarget assignments)

1

soluble

YPO2390

16122613

cfa

cyclopropane fatty acyl phospholipid syn...

383

Virulence Associated Factor

Phase 2: March 2008

1TPY

25.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00533
(show subtarget assignments)

1

purified

YPO0158

16120501

cysG

siroheme synthase

470

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

70.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00534
(show subtarget assignments)

1

purified

YPO3367

16123517

cysG

siroheme synthase

472

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

52.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00535
(show subtarget assignments)

1

soluble

YPO3506

16123652

dacB

D-alanyl-D-alanine carboxypeptidase/endo...

482

Drug Target Function

Phase 2: March 2008

2EX2

77.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00536
(show subtarget assignments)

1

soluble

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00537
(show subtarget assignments)

1

purified

YPO3924

16124055

argH

argininosuccinate lyase

457

Conserved Gene / Pathway

Phase 2: March 2008

1TJ7

88.8%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP00538
(show subtarget assignments)

1

in_pdb
3GVD

YPO0070

16120421

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

3GVD

100%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP00539
(show subtarget assignments)

1

purified

YPO2751

16122955

aroC

chorismate synthase

361

Conserved Gene / Pathway

Phase 2: March 2008

1R52

45%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00540
(show subtarget assignments)

1

purified

YPO2719

16122923

era

GTP-binding protein Era

303

Conserved Gene / Pathway

Phase 2: March 2008

1EGA

83.8%

Yersinia pestis

Cellular processes

Cell division

IDP00541
(show subtarget assignments)

1

soluble

YPO1597

16121865

fabH

3-oxoacyl-(acyl carrier protein) synthas...

316

Conserved Gene / Pathway

Phase 2: March 2008

1HN9

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00542
(show subtarget assignments)

1

cloned

YPO2744

16122948

fadL

long-chain fatty acid outer membrane tra...

423

Virulence Associated Factor

Phase 2: March 2008

1T16

64%

Yersinia pestis

Cell envelope

Other

IDP00543
(show subtarget assignments)

1

soluble

YPO4057

16124173

fdoH

formate dehydrogenase-O, iron-sulfur sub...

323

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

70.9%

Yersinia pestis

Energy metabolism

Anaerobic

IDP00544
(show subtarget assignments)

1

soluble

YPO2746

16122950

fadI

3-ketoacyl-CoA thiolase

436

Virulence Associated Factor

Phase 2: March 2008

1ULQ

37.4%

Yersinia pestis

Cellular processes

Detoxification

IDP00545
(show subtarget assignments)

1

cloned

YPO2747

16122951

fadJ

multifunctional fatty acid oxidation com...

774

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

34.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00546
(show subtarget assignments)

1

expressed

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP00547
(show subtarget assignments)

1

expressed

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP00548
(show subtarget assignments)

1

cloned

YPO0549

16120877

ftsI

penicillin-binding protein 3

587

Drug Target Function

Phase 2: March 2008

3OC2

41.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00549
(show subtarget assignments)

1

soluble

YPO3814

16123948

ftsY

cell division protein

541

Conserved Gene / Pathway

Phase 2: March 2008

2YHS

63.7%

Yersinia pestis

Cellular processes

Cell division

IDP00550
(show subtarget assignments)

1

soluble

YPO3488

16123634

deaD

ATP-dependent RNA helicase DeaD

664

Virulence Associated Factor

Phase 2: March 2008

1HV8

23.3%

Yersinia pestis

Transcription

Other

IDP00551
(show subtarget assignments)

1

soluble

YPO0589

16120918

fadH

2,4-dienoyl-CoA reductase

673

Virulence Associated Factor

Phase 2: March 2008

1PS9

72.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP00552
(show subtarget assignments)

1

soluble

YPO0282

16120621

hmuS

hemin transport protein

345

Conserved Gene / Pathway

Phase 2: March 2008

2J0R

89.6%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00553
(show subtarget assignments)

1

expressed

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00554
(show subtarget assignments)

1

purified

YPO1549

16121822

hisG

ATP phosphoribosyltransferase

299

Virulence Associated Factor

Phase 2: March 2008

1H3D

88%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP00555
(show subtarget assignments)

1

purified

YPO3424

16123573

nadC

quinolinate phosphoribosyltransferase

302

Conserved Gene / Pathway

Phase 2: March 2008

1QAP

72.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00556
(show subtarget assignments)

1

cloned

YPO2686

16122891

pgm

phosphoglucomutase

547

Drug Target Function

Phase 2: March 2008

2FUV

82.4%

Yersinia pestis

Energy metabolism

Sugars

IDP00557
(show subtarget assignments)

1

purified

YPO3382

16123531

gsrA

serine endoprotease

481

Virulence Associated Factor

Phase 2: March 2008

2ZLE

71.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00558
(show subtarget assignments)

1

purified

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00559
(show subtarget assignments)

1

purified

YPO3032

16123209

hemF

coproporphyrinogen III oxidase

309

Conserved Gene / Pathway

Phase 2: March 2008

3E8J

59.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00560
(show subtarget assignments)

1

soluble

YPO3852

16123987

hemY

putative protoheme IX biogenesis protein...

406

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Unknown function

General

IDP00561
(show subtarget assignments)

0

work_stopped

YPO1046

16121346

pyrH

uridylate kinase

241

Conserved Gene / Pathway

Phase 2: March 2008

2BNE

90.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00562
(show subtarget assignments)

1

soluble

YPO2908

16123099

hmp

nitric oxide dioxygenase

396

Virulence Associated Factor

Phase 2: March 2008

1GVH

63.1%

Yersinia pestis

Energy metabolism

Electron transport

IDP00563
(show subtarget assignments)

1

soluble

YPO0283

16120622

hmuR

hemin receptor precursor

676

Conserved Gene / Pathway

Phase 2: March 2008

3FHH

66.3%

Yersinia pestis

Transport and binding proteins

Other

IDP00564
(show subtarget assignments)

1

selected

YPO1403

16121683

mukF

condesin subunit F

440

Conserved Gene / Pathway

Phase 2: March 2008

3EUH

84.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00565
(show subtarget assignments)

1

purified

YPO0281

16120620

hmuT

hemin-binding periplasmic protein

279

Conserved Gene / Pathway

Phase 2: March 2008

3MD9

91%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00566
(show subtarget assignments)

1

soluble

YPO0279

16120618

hmuV

hemin transport system ATP-binding prote...

266

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

30.5%

Yersinia pestis

Transport and binding proteins

Other

IDP00567
(show subtarget assignments)

0

work_stopped

YPO1113

16121413

kgd

alpha-ketoglutarate decarboxylase

935

Virulence Associated Factor

Phase 2: March 2008

2JGD

87.8%

Yersinia pestis

Energy metabolism

TCA cycle

IDP00568
(show subtarget assignments)

0

work_stopped

YPO0106

16120453

hslV

ATP-dependent protease peptidase subunit...

174

Conserved Gene / Pathway

Phase 2: March 2008

1E94

90.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00569
(show subtarget assignments)

1

soluble

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00570
(show subtarget assignments)

1

expressed

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP00571
(show subtarget assignments)

1

in_pdb
3GOS

YPO1041

16121341

dapD

2,3,4,5-tetrahydropyridine-2-carboxylate...

274

Virulence Associated Factor

Phase 2: March 2008

3GOS

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00572
(show subtarget assignments)

1

cloned

YPO2717

16122921

lepB

lsignal peptidase I

332

Drug Target Function

Phase 2: March 2008

1T7D

54.8%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00573
(show subtarget assignments)

1

in_pdb
3GO9

YPO3991

16124118

putative insulinase family protease

499

Drug Target Function

Phase 2: March 2008

3GO9

98.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00574
(show subtarget assignments)

1

cloned

YPO0531

16120860

leuC

isopropylmalate isomerase large subunit ...

476

Virulence Associated Factor

Phase 2: March 2008

1ACO

25%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP00575
(show subtarget assignments)

1

in_pdb
3V4Z

YPO0557

16120885

ddl

D-alanine--D-alanine ligase

306

Drug Target Function

Phase 2: March 2008

3V4Z

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00576
(show subtarget assignments)

1

cloned

YPO1398

16121678

cspB

cold shock-like protein

69

Virulence Associated Factor

Phase 2: March 2008

3I2Z

50.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP00577
(show subtarget assignments)

1

in_pdb
3OYT

YPO2757

16122961

fabB

3-oxoacyl-(acyl carrier protein) synthas...

407

Virulence Associated Factor

Phase 2: March 2008

3OYT

100%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00578
(show subtarget assignments)

1

purified

YPO3553

16123697

elbB

isoprenoid biosynthesis protein with ami...

217

Drug Target Function

Phase 2: March 2008

1OY1

63.6%

Yersinia pestis

Unknown function

General

Targets