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Targets
Filter Targets:
Selection Phase:
No Filter
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM 10
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
Clostridium difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
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Keyword:
Type Keyword
Stage:
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cloned
crystallized
crystal_structure
diffraction
expressed
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
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CSGID ID
Priority
stage
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04273
(
show subtarget assignments
)
1
cloned
YPCD1.23
5832444
YPCD1.23
hypothetical protein YPCD1.23 [Yersinia ...
139
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP91782
(
show subtarget assignments
)
8
purified
CAA38136
46982
fosB
fosB [Staphylococcus epidermidis]
139
drug resistance /
Fosfomycin resistance
Community Requests
3UH9
59.7%
Staphylococcus epidermidis
IDP01511
(
show subtarget assignments
)
1
expressed
VC0794
15640812
hypothetical protein VC0794
139
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP90175
(
show subtarget assignments
)
8
expressed
AAM13468.1
20153007
VGF
CPXV021 protein or CPXV VGF protein
139
similar to viral growth factor C11R vaccinia virus
Community Requests
1K36
15.8%
Cowpox virus
host range protein
0
IDP00849
(
show subtarget assignments
)
1
cloned
SACOL2326
57285061
fosB
fosfomycin resistance protein FosB
139
Conserved Gene / Pathway
Phase 2: March 2008
3UH9
64.7%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP00079
(
show subtarget assignments
)
1
in_pdb
3DSA
3E7N
NT01ST4845
16422456
rbsD
D-ribose high-affinity transport system ...
139
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3DSA
100%
Salmonella enterica
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP02772
(
show subtarget assignments
)
1
purified
STM2649
16765969
trxC
thioredoxin 2 [Salmonella typhimurium LT...
139
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3P2A
76.3%
Salmonella enterica
Energy metabolism
Electron transport
IDP00892
(
show subtarget assignments
)
0
work_stopped
STM3881
16767165
rbsD
high-affinity D-ribose transport protein...
139
Conserved Gene / Pathway
Phase 2: March 2008
3DSA
100%
Salmonella enterica
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05011
(
show subtarget assignments
)
1
soluble
BA_4970
30259463
hypothetical protein BA_4970 [Bacillus a...
139
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP90377
(
show subtarget assignments
)
8
purified
CT_274
3328687
hypothetical protein [Chlamydia trachoma...
139
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3KD7
15.1%
Chlamydia trachomatis
IDP00840
(
show subtarget assignments
)
1
purified
SACOL1894
57284813
HIT family protein
140
Drug Target Function
Phase 2: March 2008
1Y23
52.1%
Staphylococcus aureus
Unknown function
General
IDP91207
(
show subtarget assignments
)
8
soluble
BT_2842
29348251
3-dehydroquinate dehydratase [Bacteroide...
140
potential drug target /
Shikimate pathway enzyme
Community Requests
2C4W
49%
Bacteroides thetaiotaomicron
IDP00186
(
show subtarget assignments
)
1
soluble
YPO0695
16121016
-
putative membrane protein
140
Virulence
Phase 1: October 2007
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP90088
(
show subtarget assignments
)
8
soluble
ZZZ_0004
140
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP91612
(
show subtarget assignments
)
8
purified
BAB36911
13362959
ECs3488
hypothetical protein [Escherichia coli O...
140
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2KKX
27.1%
Escherichia coli
IDP04706
(
show subtarget assignments
)
1
expressed
BAS0105
49183139
30S ribosomal protein S12 [Bacillus anth...
140
Proposed to be essential proteins
Phase 4: April 2009
2F4V
71.4%
Bacillus anthracis
IDP01880
(
show subtarget assignments
)
1
in_pdb
3N77
3OGA
STM2295
16765622
yfaO
putative NTP pyrophosphohydrolase [Salmo...
141
Conserved; Drug target functions
Phase 3: June 2008
3OGA
100%
Salmonella enterica
Unknown function
General
IDP00468
(
show subtarget assignments
)
1
soluble
YPO0337
16120673
hypothetical protein YPO0337
141
Virulence Associated Factor
Phase 2: March 2008
3DWA
50.4%
Yersinia pestis
Cell envelope
Other
IDP05485
(
show subtarget assignments
)
1
cloned
BA_3234
30257796
putative lipoprotein [Bacillus anthracis...
141
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90391
(
show subtarget assignments
)
8
purified
CT_550
3328989
hypothetical protein [Chlamydia trachoma...
141
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02174
(
show subtarget assignments
)
1
cloned
YPO3031
16123208
putative acetyltransferase [Yersinia pes...
141
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
2PDO
78%
Yersinia pestis
Central intermediary metabolism
Other
IDP00603
(
show subtarget assignments
)
1
cloned
SACOL0726
57285695
sarX
staphylococcal accessory protein X
141
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP00579
(
show subtarget assignments
)
1
cloned
YPO1122
16121422
tolR
colicin uptake protein TolR
142
Conserved Gene / Pathway
Phase 2: March 2008
2JWK
23.9%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP00055
(
show subtarget assignments
)
0
work_stopped
BA_3696
30258217
blasticidin S deaminase, putative
142
Virulence
Phase 1: October 2007
3B8F
99.3%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP04321
(
show subtarget assignments
)
1
cloned
VC0756
15640775
ndk
nucleoside diphosphate kinase [Vibrio ch...
142
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2HUR
64.8%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Nucleotide and nucleoside interconversions
IDP01613
(
show subtarget assignments
)
1
purified
STM1927
16765269
yecG
universal stress protein UspC [Salmonell...
142
Conserved; Drug target functions
Phase 3: June 2008
1JMV
35.2%
Salmonella enterica
Cellular processes
Adaptations to atypical conditions
IDP05137
(
show subtarget assignments
)
1
soluble
CD0227
126697798
hypothetical protein CD0227 [Clostridium...
142
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2QUP
26.4%
Clostridium difficile
Hypothetical proteins: Conserved
IDP05001
(
show subtarget assignments
)
1
purified
BA_1090
30254820
putative lipoprotein [Bacillus anthracis...
142
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90106
(
show subtarget assignments
)
8
cloned
MPXV_ZAI1979_005_011
68449085
secreted epidermal growth factor-like pr...
142
similar to VACV-COP-C11R, MPXV-ZAI96-D3R
Community Requests
1K36
16.2%
Monkeypox virus
IDP91487
(
show subtarget assignments
)
8
soluble
VP1697
28898471
putative type III export apparatus prote...
142
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1XKP
20.4%
Vibrio parahaemolyticus
IDP04353
(
show subtarget assignments
)
1
expressed
YPCD1.96c
5832511
YPCD1.96c
putative transposase [Yersinia pestis CO...
143
drug target; virulence factor; conserved gene; putative drug target function;...
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP01714
(
show subtarget assignments
)
1
cloned
Cj0528c
15791889
flgB
flagellar basal body rod protein FlgB [C...
143
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Cell envelope
Other
IDP05508
(
show subtarget assignments
)
1
cloned
BA_5398
30259871
putative lipoprotein [Bacillus anthracis...
143
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP01305
(
show subtarget assignments
)
1
soluble
VC1064
15641077
lipoprotein-related protein
143
Conserved Gene / Pathway
Phase 2: March 2008
Vibrio cholerae
Cell envelope
Other
IDP05175
(
show subtarget assignments
)
1
cloned
lmo1656
16803696
-
hypothetical protein lmo1656 [Listeria m...
143
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP02451
(
show subtarget assignments
)
1
in_pdb
3IMI
GBAA1047
47526323
HIT family protein [Bacillus anthracis s...
144
Drug target motif; Involved in sporulation;
Phase 3: June 2008
3IMI
100%
Bacillus anthracis
Unknown function
General
IDP91401
(
show subtarget assignments
)
8
soluble
VV1_0994
27364429
16 kDa heat shock protein A [Vibrio vuln...
144
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP01061
(
show subtarget assignments
)
1
purified
STM3591
16766877
uspA
universal stress protein A
144
Conserved Gene / Pathway
Phase 2: March 2008
1JMV
66.7%
Salmonella enterica
Cellular processes
Adaptations to atypical conditions
IDP05647
(
show subtarget assignments
)
1
cloned
CD3457
126701080
hypothetical protein CD3457 [Clostridium...
144
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP00739
(
show subtarget assignments
)
1
purified
SACOL1063
57284433
acetyltransferase, GNAT family
144
Drug Target Function
Phase 2: March 2008
1Q2Y
40.3%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP00871
(
show subtarget assignments
)
0
work_stopped
STM1444
161353603
slyA
transcriptional regulator SlyA
144
Drug Target Function
Phase 2: March 2008
3Q5F
98.6%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP05010
(
show subtarget assignments
)
1
soluble
BA_4934
30259430
putative lipoprotein [Bacillus anthracis...
144
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP91064
(
show subtarget assignments
)
1
cloned
y2422
21959284
144
other biological interest /
Identified in a mutant screen
Community Requests
Yersinia pestis
IDP05704
(
show subtarget assignments
)
1
cloned
lmo2639
16804677
-
hypothetical protein lmo2639 [Listeria m...
138
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KPP
33.3%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP05481
(
show subtarget assignments
)
1
cloned
BA_3883
30258397
conserved hypothetical protein [Bacillus...
144
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP01393
(
show subtarget assignments
)
1
purified
VC0684
15640703
peptidyl-prolyl cis-trans isomerase, FKB...
144
Conserved Gene / Pathway
Phase 2: March 2008
2K8I
33.3%
Vibrio cholerae
Protein fate
Protein folding and stabilization
IDP04586
(
show subtarget assignments
)
1
cloned
BAS0117
49183151
50S ribosomal protein L16 [Bacillus anth...
144
Proposed to be essential proteins
Phase 4: April 2009
1VSA
60.4%
Bacillus anthracis
IDP90402
(
show subtarget assignments
)
8
purified
CT_635
3329083
hypothetical protein [Chlamydia trachoma...
144
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00818
(
show subtarget assignments
)
1
purified
SACOL2148
57286362
PTS system, mannitol-specific IIA compon...
144
Drug Target Function
Phase 2: March 2008
1A3A
34.7%
Staphylococcus aureus
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP05040
(
show subtarget assignments
)
1
expressed
BA_2262
30256905
heat shock protein, Hsp20 family [Bacill...
145
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1GME
30.3%
Bacillus anthracis
Cellular processes: Adaptations to atypical conditions
IDP04592
(
show subtarget assignments
)
1
expressed
BAS0143
49183177
50S ribosomal protein L13 [Bacillus anth...
145
Proposed to be essential proteins
Phase 4: April 2009
1P85
56.6%
Bacillus anthracis
IDP91606
(
show subtarget assignments
)
8
expressed
CBU_1532
29542091
hypothetical protein
145
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Coxiella burnetii
IDP91868
(
show subtarget assignments
)
8
selected
AAA21889
455437
aac(6')-Ig
aminoglycoside 6'-N-acetyltransferase [A...
145
drug resistance /
confers resistance to aminoglycoside antibiotics by acetylation
Community Requests
1S3Z
40%
Acinetobacter haemolyticus
IDP91920
(
show subtarget assignments
)
8
selected
SpneCM_010100000782
298254135
Spn1 transposase, partial [Streptococcus...
145
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP05019
(
show subtarget assignments
)
1
cloned
CD0267
126697839
hypothetical protein CD0267 [Clostridium...
145
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP04715
(
show subtarget assignments
)
1
expressed
YPO0813
115346604
general secretion pathway protein G [Yer...
145
drug target; putative drug target function;
Phase 4: April 2009
3G20
51%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP02182
(
show subtarget assignments
)
1
cloned
FTT0065
56707244
atpC
F0F1 ATP synthase subunit epsilon [Franc...
145
Conserved; Drug target functions
Phase 3: June 2008
2QE7
33.1%
Francisella tularensis
Energy metabolism
ATP-proton motive force interconversion
IDP01228
(
show subtarget assignments
)
1
purified
BA_4283
30258785
peptidyl-prolyl cis-trans isomerase, cyc...
145
Conserved Gene / Pathway
Phase 2: March 2008
1AK4
42.1%
Bacillus anthracis
Protein fate
Protein folding and stabilization
IDP04482
(
show subtarget assignments
)
1
in_pdb
3P2A
YPO3270
218930295
trxC
thioredoxin 2 [Yersinia pestis CO92]
145
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3P2A
100%
Yersinia pestis
Energy metabolism
Electron transport
IDP01325
(
show subtarget assignments
)
1
in_pdb
3EER
3I07
3LUS
VCA1006
15601759
organic hydroperoxide resistance protein...
145
Conserved Gene / Pathway
Phase 2: March 2008
3EER
100%
Vibrio cholerae
Cellular processes
Detoxification
IDP02679
(
show subtarget assignments
)
1
cloned
FTT0889c
56707990
Type IV pili fiber building block protei...
146
Drug Target
Phase 3: June 2008
3SOJ
76.7%
Francisella tularensis
Cell envelopeCellular processes
Surface structuresPathogenesis
IDP05276
(
show subtarget assignments
)
1
cloned
BA_4236
30258739
putative lipoprotein [Bacillus anthracis...
146
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP00098
(
show subtarget assignments
)
1
soluble
NT01SF2011
30041408
slyA
transcriptional regulator
146
Virulence
Phase 1: October 2007
3DEU
88.4%
Shigella flexneri
Cellular processes
Toxin production and resistance
IDP04071
(
show subtarget assignments
)
1
cloned
BAS0129
49183163
50S ribosomal protein L15 [Bacillus anth...
146
Proposed to be essential proteins
Phase 4: April 2009
1VSA
51.4%
Bacillus anthracis
IDP90324
(
show subtarget assignments
)
8
expressed
CT088
15604807
sycE
secretion chaperone [Chlamydia trachomat...
146
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91869
(
show subtarget assignments
)
8
selected
AAC41391
547387
aac(6')-Ih
aac(6')-Ih [Acinetobacter baumannii]
146
drug resistance /
confers resistance to aminoglycoside antibiotics by acetylation
Community Requests
1S3Z
43.8%
Acinetobacter baumannii
IDP02836
(
show subtarget assignments
)
1
purified
GBAA4423
47529716
aroQ
3-dehydroquinate dehydratase [Bacillus a...
146
Conserved; Drug target functions
Phase 3: June 2008
1GQO
57.5%
Bacillus anthracis
Amino acid biosynthesis
Aromatic amino acid family
IDP04018
(
show subtarget assignments
)
1
cloned
CPF_1860
110799668
msrB
methionine sulfoxide reductase B [Clostr...
147
conserved gene; putative drug target function;
Phase 4: April 2009
1XM0
64.6%
Clostridium perfringens
Cellular processes
Adaptations to atypical conditions
IDP04316
(
show subtarget assignments
)
1
expressed
YPO0503
115346312
conserved hypothetical protein [Yersinia...
147
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP01845
(
show subtarget assignments
)
1
cloned
STM0017
16763407
hypothetical protein STM0017 [Salmonella...
147
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unclassified
Role category not yet assigned
IDP01691
(
show subtarget assignments
)
1
cloned
CBU_1575
29542135
tolR
tolR protein [Coxiella burnetii RSA 493]...
147
Conserved; Drug target functions
Phase 3: June 2008
Coxiella burnetii
Transport and binding proteins
Other
IDP01043
(
show subtarget assignments
)
1
soluble
STM2985
16766289
ygdK
putative FeS center assembly protein
147
Conserved Gene / Pathway
Phase 2: March 2008
1NI7
86.4%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02530
(
show subtarget assignments
)
1
soluble
FTT1674
56708684
ribH
riboflavin synthase beta subunit (6,7-di...
147
Conserved; Drug target functions
Phase 3: June 2008
1RVV
45.6%
Francisella tularensis
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP01719
(
show subtarget assignments
)
1
purified
GBAA5560
47530880
ribose-5-phosphate isomerase B [Bacillus...
147
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3HE8
55.1%
Bacillus anthracis
Energy metabolism
Sugars
IDP02609
(
show subtarget assignments
)
1
in_pdb
3LQN
GBAA4196
47529491
CBS domain-containing protein [Bacillus ...
147
Drug target motif;
Phase 3: June 2008
3LQN
100%
Bacillus anthracis
Unknown function
General
IDP04293
(
show subtarget assignments
)
1
in_pdb
3OXP
YPO2569
218929655
phosphotransferase enzyme II, A componen...
147
conserved gene; putative drug target function;
Phase 4: April 2009
3OXP
100%
Yersinia pestis
Amino acid biosynthesis
Aromatic amino acid family
IDP05466
(
show subtarget assignments
)
1
soluble
BA_1948
30256606
putative lipoprotein [Bacillus anthracis...
148
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP91202
(
show subtarget assignments
)
8
in_pdb
3U80
BLD_0610
189439473
aroQ
3-dehydroquinate dehydratase [Bifidobact...
148
potential drug target /
Shikimate pathway enzyme
Community Requests
3U80
100%
Bifidobacterium longum
IDP90362
(
show subtarget assignments
)
8
soluble
CT_053
3328445
hypothetical protein [Chlamydia trachoma...
148
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90351
(
show subtarget assignments
)
8
cloned
CT165
15604884
hypothetical protein CT165 [Chlamydia tr...
148
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91484
(
show subtarget assignments
)
8
purified
VP1701
28898475
putative exoenzyme S synthesis protein C...
148
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3KXY
30.4%
Vibrio parahaemolyticus
IDP04628
(
show subtarget assignments
)
1
soluble
BAS5322
49188306
50S ribosomal protein L9 [Bacillus anthr...
148
Proposed to be essential proteins
Phase 4: April 2009
1DIV
75%
Bacillus anthracis
IDP05363
(
show subtarget assignments
)
1
soluble
BA_2032
30256684
hypothetical protein BA_2032 [Bacillus a...
148
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP00725
(
show subtarget assignments
)
1
cloned
SACOL1919
57284837
transcriptional regulator, Fur family
148
Conserved Gene / Pathway
Phase 2: March 2008
2FE3
63.5%
Staphylococcus aureus
Transport and binding proteins
Cations and iron carrying compounds
IDP05288
(
show subtarget assignments
)
1
expressed
CD0252
126697823
fliJ
flagellar protein [Clostridium difficile...
148
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP00642
(
show subtarget assignments
)
1
soluble
SACOL2384
57285116
sarZ
staphylococcal accessory protein Z
148
Conserved Gene / Pathway
Phase 2: March 2008
3HRM
91.9%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP05012
(
show subtarget assignments
)
1
cloned
BA_5070
30259559
cell wall surface anchor family protein ...
148
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90084
(
show subtarget assignments
)
8
soluble
ZP_01795673
145640079
hypothetical protein CGSHiII_00674 [Haem...
148
The protein we would like structure analyzed is from Haemophilus influenzae. Pri...
Community Requests
2XM6
28.4%
Haemophilus influenzae
IDP91026
(
show subtarget assignments
)
8
cloned
y3142
22127018
flavodoxin [Yersinia pestis KIM 10]
149
other biological interest /
oxidative stress response protein
Community Requests
2HNA
33.6%
Yersinia pestis
IDP90569
(
show subtarget assignments
)
8
soluble
VC0369
15640396
rplI
50S ribosomal protein L9 [Vibrio cholera...
149
Predicted Essential
Community Requests
1P85
76.5%
Vibrio cholerae
IDP05621
(
show subtarget assignments
)
1
cloned
CD0867
126698444
hypothetical protein CD0867 [Clostridium...
149
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP90123
(
show subtarget assignments
)
8
purified
MPXV_ZAI1979_005_035
68449109
B15R-like protein [Monkeypox virus]
149
similar to VACV-COP-K7R, MPXV-ZAI96-C6R
Community Requests
2K36
94%
Monkeypox virus
IDP92036
(
show subtarget assignments
)
8
selected
TGME49_033720
237837845
RNA polymerase, putative [Toxoplasma gon...
149
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
IDP00861
(
show subtarget assignments
)
1
soluble
STM2117
16765447
wzb
tyrosine phosphatase
149
Conserved Gene / Pathway
Phase 2: March 2008
2FEK
81.9%
Salmonella enterica
Central intermediary metabolism
Other
IDP01022
(
show subtarget assignments
)
1
purified
STM0048
16763438
slpA
FKBP-type peptidyl-prolyl cis-trans isom...
149
Conserved Gene / Pathway
Phase 2: March 2008
3PR9
29.5%
Salmonella enterica
Protein synthesis
Translation factors
IDP90409
(
show subtarget assignments
)
8
purified
CT_667
3329118
hypothetical protein [Chlamydia trachoma...
149
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP04314
(
show subtarget assignments
)
1
purified
YPCD1.73c
5832493
YPCD1.73c
hypothetical protein YPCD1.73c [Yersinia...
149
virulence factor; conserved gene;
Phase 4: April 2009
1JSC
40.7%
Yersinia pestis
IDP01964
(
show subtarget assignments
)
1
in_pdb
3KWO
Cj1534c
15792842
bacterioferritin [Campylobacter jejuni s...
149
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
3KWO
100%
Campylobacter jejuni
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP90142
(
show subtarget assignments
)
8
soluble
MPXV_ZAI1979_005_188
68449259
unknown [Monkeypox virus]
149
similar to VACV-COP-B15R, MPXV-ZAI96-B13R
Community Requests
2VVY
93.3%
Monkeypox virus
IDP05589
(
show subtarget assignments
)
1
soluble
BA_2931
30257523
putative lipoprotein [Bacillus anthracis...
149
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
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