Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04682 (show subtarget assignments)	1	cloned	GBAA3189	47528481		adhesion lipoprotein [Bacillus anthracis...	311	virulence factor; putative drug target function;	Phase 4: April 2009	3HH8	49.8%	Bacillus anthracis	Cell envelope	Other

IDP04683 (show subtarget assignments)	1	expressed	GBAA3269	47528557		iron-sulfur cluster-binding protein [Bac...	470	virulence factor; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Energy metabolism	Electron transport

IDP02473 (show subtarget assignments)	1	purified	GBAA3967	47529257	hslU	ATP-dependent protease ATP-binding subun...	463	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1E94	50.8%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01877 (show subtarget assignments)	1	crystallized	GBAA0080	47525336		negative regulator of genetic competence...	811	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PXI	80.1%	Bacillus anthracis	Cellular processes	DNA transformation

IDP04430 (show subtarget assignments)	1	purified	GBAA4921	47530215		sensor histidine kinase [Bacillus anthra...	484	putative drug target function;	Phase 4: April 2009	2C2A	16.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01876 (show subtarget assignments)	1	cloned	GBAA0095	47525349	secE	preprotein translocase subunit SecE [Bac...	59	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DIN	33.9%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02455 (show subtarget assignments)	1	expressed	GBAA3813	47529098		prophage LambdaBa01, thymidylate synthas...	252	Conserved; Drug target functions	Phase 3: June 2008	3AH5	24.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02489 (show subtarget assignments)	1	selected	GBAA3099	47528392	sipU	Signal peptidase I U [Bacillus anthracis...	183	Drug target motif; Drug target functions	Phase 3: June 2008	1T7D	27.8%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP04431 (show subtarget assignments)	1	cloned	GBAA5088	47530387		sensor histidine kinase [Bacillus anthra...	340	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	18.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01683 (show subtarget assignments)	1	expressed	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02453 (show subtarget assignments)	1	in_pdb 3IGJ 3HJJ	GBAA3402	47528687	maA	maltose O-acetyltransferase [Bacillus an...	187	Drug target motif; Conserved; Essential; Drug target functions	Phase 3: June 2008	3HJJ	100%	Bacillus anthracis	Cellular processes	Detoxification

IDP02456 (show subtarget assignments)	1	crystallized	GBAA3921	47529213	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	237	Conserved; Essential;	Phase 3: June 2008	2P68	38.1%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01875 (show subtarget assignments)	1	expressed	GBAA0069	47525323	pabA-1	para-aminobenzoate/anthranilate synthase...	195	Conserved; Essential; Drug target functions	Phase 3: June 2008	1QDL	45.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02454 (show subtarget assignments)	1	in_pdb 3HYL 3M49	GBAA3744	47529034	tkt-2	transketolase [Bacillus anthracis str. '...	666	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HYL	100%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP02830 (show subtarget assignments)	1	soluble	GBAA4861	47530155	pepQ-2	proline dipeptidase [Bacillus anthracis ...	365	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WY2	38.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04675 (show subtarget assignments)	1	soluble	GBAA2291	47527591		sensor histidine kinase [Bacillus anthra...	377	putative drug target function;	Phase 4: April 2009	3A0R	26.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01678 (show subtarget assignments)	1	cloned	GBAA5591	47530913		cardiolipin synthetase domain-containing...	397	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04352 (show subtarget assignments)	1	expressed	GBAA0584	47525859		sensor histidine kinase [Bacillus anthra...	487	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01813 (show subtarget assignments)	1	purified	GBAA1253	47526519	trpB	tryptophan synthase subunit beta [Bacill...	397	Conserved; Drug target functions	Phase 3: June 2008	1X1Q	63%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02335 (show subtarget assignments)	1	expressed	GBAA2583	47527873		hypothetical protein GBAA2583 [Bacillus ...	563	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3SKS	26.3%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01681 (show subtarget assignments)	1	cloned	GBAA4795	47530092		hypothetical protein GBAA4795 [Bacillus ...	572	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3AU2	37.1%	Bacillus anthracis	Unknown function	General

IDP02005 (show subtarget assignments)	1	cloned	GBAA0543	47525816		penicillin-binding domain-containing pro...	258	Drug target homolog; Involved in sporulation;	Phase 3: June 2008	2OQO	36%	Bacillus anthracis	Unknown function	General

IDP02831 (show subtarget assignments)	1	purified	GBAA4686	47529986	maf	Maf-like protein [Bacillus anthracis str...	191	Conserved; Drug target functions	Phase 3: June 2008	1EX2	53.4%	Bacillus anthracis	Cellular processes	Cell division

IDP01682 (show subtarget assignments)	1	cloned	GBAA5104	47530405		D-alanyl-D-alanine carboxypeptidase fami...	286	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01874 (show subtarget assignments)	1	cloned	GBAA0062	47525316		hypothetical protein GBAA0062 [Bacillus ...	476	Conserved;	Phase 3: June 2008	3A2K	46.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01712 (show subtarget assignments)	1	in_pdb 3EFE	GBAA2657	47551781		thiJ/pfpI family protein [Bacillus anthr...	210	CONSERVED	Phase 3: June 2008	3EFE	100%	Bacillus anthracis	N/A	N/A

IDP01881 (show subtarget assignments)	1	cloned	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04342 (show subtarget assignments)	1	cloned	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04676 (show subtarget assignments)	1	soluble	GBAA2370	47527665	dhbE	2,3-dihydroxybenzoate-AMP ligase [Bacill...	538	putative drug target function;	Phase 4: April 2009	1MD9	71.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01668 (show subtarget assignments)	1	soluble	GBAA0060	47525314		hypothetical protein GBAA0060 [Bacillus ...	160	Essential;	Phase 3: June 2008	2K4K	29.4%	Bacillus anthracis	Unknown function	General

IDP01670 (show subtarget assignments)	1	cloned	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	Phase 3: June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02328 (show subtarget assignments)	1	expressed	GBAA2548	47527837		acetyl-CoA carboxylase biotin carboxylas...	445	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N6R	51.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01672 (show subtarget assignments)	1	soluble	GBAA5133	47530438		hypothetical protein GBAA5133 [Bacillus ...	396	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1DJU	48.2%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01782 (show subtarget assignments)	1	expressed	GBAA0752	47526035	scrK	fructokinase [Bacillus anthracis str. 'A...	313	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3EWM	33.8%	Bacillus anthracis	Energy metabolism	Sugars

IDP02329 (show subtarget assignments)	1	in_pdb 3KQF	GBAA2551	47527840		enoyl-CoA hydratase [Bacillus anthracis ...	262	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3KQF	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04669 (show subtarget assignments)	1	expressed	GBAA1351	47526623		sensor histidine kinase KinD [Bacillus a...	498	putative drug target function;	Phase 4: April 2009	3D36	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01663 (show subtarget assignments)	1	purified	GBAA4696	47529995	hemC	porphobilinogen deaminase [Bacillus anth...	309	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02519 (show subtarget assignments)	1	cloned	GBAA1494	47526768	resA	thiol-disulfide oxidoreductase [Bacillus...	173	Conserved; Drug target functions	Phase 3: June 2008	1ST9	41.6%	Bacillus anthracis	Energy metabolism	Electron transport

IDP01868 (show subtarget assignments)	1	cloned	GBAA5583	47530904	ctrA	CTP synthetase [Bacillus anthracis str. ...	535	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1S1M	56.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02330 (show subtarget assignments)	1	cloned	GBAA1419	47526691	ilvC-1	ketol-acid reductoisomerase [Bacillus an...	336	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	55.7%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP01792 (show subtarget assignments)	1	expressed	GBAA0866	47777865	alsS	acetolactate synthase [Bacillus anthraci...	562	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1OZF	50.7%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04424 (show subtarget assignments)	1	expressed	GBAA4024	47529317	pyrK	dihydroorotate dehydrogenase electron tr...	259	putative drug target function;	Phase 4: April 2009	1EP3	48.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01666 (show subtarget assignments)	1	soluble	GBAA4704	47530003	clpX	ATP-dependent protease ATP-binding subun...	419	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HTE	52.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01673 (show subtarget assignments)	1	soluble	GBAA5206	47530513		M23/37 family peptidase [Bacillus anthra...	327	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	3SLU	25.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01796 (show subtarget assignments)	1	cloned	GBAA5258	47778380		cell wall surface anchor family protein ...	627	Drug target homolog; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Other

IDP01795 (show subtarget assignments)	1	expressed	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02822 (show subtarget assignments)	1	cloned	GBAA4819	47778330	infC	translation initiation factor IF-3 [Baci...	186	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TIG	40.9%	Bacillus anthracis	Protein synthesis	Translation factors

IDP04670 (show subtarget assignments)	1	expressed	GBAA1356	47526628	kinB-1	sporulation kinase B [Bacillus anthracis...	402	putative drug target function;	Phase 4: April 2009	3D36	25.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01800 (show subtarget assignments)	1	soluble	GBAA1129	47526399		S-layer protein, putative [Bacillus anth...	219	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.1%	Bacillus anthracis	Cell envelope	Surface structures

IDP01799 (show subtarget assignments)	1	soluble	GBAA1127	47526398		S-layer protein, putative [Bacillus anth...	223	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.6%	Bacillus anthracis	Cell envelope	Surface structures

IDP02439 (show subtarget assignments)	1	cloned	GBAA3892	47529180		serine protease [Bacillus anthracis str....	613	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2OXA	16.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02432 (show subtarget assignments)	1	soluble	GBAA3687	47528971		acetyl-CoA acetyltransferase [Bacillus a...	363	Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...	Phase 3: June 2008	4DD5	39.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP02528 (show subtarget assignments)	1	soluble	GBAA4405	47529699	folD	methylenetetrahydrofolate dehydrogenase/...	286	Essential; Drug target functions	Phase 3: June 2008	3P2O	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02524 (show subtarget assignments)	1	purified	GBAA1852	47527143	ilvC-2	ketol-acid reductoisomerase [Bacillus an...	335	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	56.1%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02815 (show subtarget assignments)	1	soluble	GBAA4880	47530173	argG	argininosuccinate synthase [Bacillus ant...	401	Conserved; Drug target functions	Phase 3: June 2008	1VL2	46.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02331 (show subtarget assignments)	1	selected	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01661 (show subtarget assignments)	1	soluble	GBAA4609	47529906		U32 family peptidase [Bacillus anthracis...	426	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02816 (show subtarget assignments)	1	soluble	GBAA4014	47529307		proline dipeptidase, putative [Bacillus ...	356	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3Q6D	56.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02818 (show subtarget assignments)	1	selected	GBAA4027	47529320	pyrC	dihydroorotase [Bacillus anthracis str. ...	428	Conserved; Drug target functions	Phase 3: June 2008	3MPG	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02319 (show subtarget assignments)	1	purified	GBAA1169	47526434	prsA	peptidylprolyl isomerase [Bacillus anthr...	285	Drug target motif; Drug target functions	Phase 3: June 2008	3RFW	29.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02320 (show subtarget assignments)	1	purified	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01870 (show subtarget assignments)	1	cloned	GBAA5710	47531047		serine protease [Bacillus anthracis str....	391	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GCN	31.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02325 (show subtarget assignments)	1	in_pdb 3IMF	GBAA4204	47778260		short chain dehydrogenase [Bacillus anth...	254	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3IMF	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02824 (show subtarget assignments)	1	purified	GBAA5152	47530456	gtaB	UTP-glucose-1-phosphate uridylyltransfer...	295	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2UX8	51.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04671 (show subtarget assignments)	1	soluble	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02315 (show subtarget assignments)	1	cloned	GBAA1132	47526402	aceA	isocitrate lyase [Bacillus anthracis str...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4E	71.4%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP01650 (show subtarget assignments)	1	in_pdb 3IFS	GBAA5130	47530435	pgi	glucose-6-phosphate isomerase [Bacillus ...	450	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IFS	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02807 (show subtarget assignments)	1	purified	GBAA4705	47530004	tig	trigger factor [Bacillus anthracis str. ...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T11	32.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02425 (show subtarget assignments)	1	soluble	GBAA2775	47528067	acoB	TPP-dependent acetoin dehydrogenase E1 b...	344	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1W85	43.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02427 (show subtarget assignments)	1	purified	GBAA3553	47528837	pepF-2	oligoendopeptidase F [Bacillus anthracis...	595	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QR4	37.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04666 (show subtarget assignments)	1	purified	GBAA1158	47526425	hemH-2	ferrochelatase [Bacillus anthracis str. ...	319	putative drug target function;	Phase 4: April 2009	2C8J	62.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02313 (show subtarget assignments)	1	cloned	GBAA3973	47529263	sucD	succinyl-CoA synthetase subunit alpha [B...	300	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JKJ	62.3%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP01653 (show subtarget assignments)	1	cloned	GBAA4538	47529835	dnaJ	chaperone protein dnaJ [Bacillus anthrac...	371	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LZ8	34%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02362 (show subtarget assignments)	1	cloned	GBAA1923	47777980	ldh	L-lactate dehydrogenase [Bacillus anthra...	314	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PQD	64.6%	Bacillus anthracis	Energy metabolism	Anaerobic

IDP02314 (show subtarget assignments)	1	cloned	GBAA0599	47525877		neutral protease [Bacillus anthracis str...	566	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1NPC	53%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01646 (show subtarget assignments)	1	soluble	GBAA5119	47530423	glgP	glycogen phosphorylase [Bacillus anthrac...	802	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AXR	46.5%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04665 (show subtarget assignments)	1	purified	GBAA1118	47526389		sensor histidine kinase [Bacillus anthra...	580	putative drug target function;	Phase 4: April 2009	2C2A	11.4%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04667 (show subtarget assignments)	1	cloned	GBAA1313	47526578		sensor histidine kinase [Bacillus anthra...	466	putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01639 (show subtarget assignments)	1	cloned	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01640 (show subtarget assignments)	1	purified	GBAA4357	47529653		short chain dehydrogenase/reductase fami...	264	Conserved; Essential;	Phase 3: June 2008	3P19	33.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02318 (show subtarget assignments)	1	purified	GBAA1251	47526517	trpC	indole-3-glycerol-phosphate synthase [Ba...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TSM	40.7%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02332 (show subtarget assignments)	1	purified	GBAA1462	47526735		UbiE/COQ5 family methlytransferase [Baci...	258	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UJD	22.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01675 (show subtarget assignments)	1	purified	GBAA5217	47530523		ABC transporter ATP-binding protein [Bac...	261	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2D2E	57.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02428 (show subtarget assignments)	1	expressed	GBAA3580	47528865		O-acetyltransferase, putative [Bacillus ...	188	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3VBI	99.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02826 (show subtarget assignments)	1	purified	GBAA4254	47529547		transaminase [Bacillus anthracis str. 'A...	392	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	2O1B	40.8%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01865 (show subtarget assignments)	1	in_pdb 3Q94	GBAA5580	47530901	fba-2	fructose-bisphosphate aldolase [Bacillus...	285	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3Q94	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01637 (show subtarget assignments)	1	crystallized	GBAA5111	47530413	menD	2-succinyl-6-hydroxy-2,4-cyclohexadiene-...	584	Conserved; Drug target functions	Phase 3: June 2008	2X7J	46.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02549 (show subtarget assignments)	1	soluble	GBAA0547	47525820		RNA methyltransferase [Bacillus anthraci...	162	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L8U	51.2%	Bacillus anthracis	Protein synthesis	tRNA and rRNA base modification

IDP02312 (show subtarget assignments)	1	expressed	GBAA2190	47778017		FtsK/SpoIIIE family protein [Bacillus an...	1342	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IUT	7.4%	Bacillus anthracis	Cellular processes	Cell division

IDP02157 (show subtarget assignments)	1	expressed	GBAA3961	47778228	uppS	undecaprenyl diphosphate synthase [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1F75	55.8%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02442 (show subtarget assignments)	1	soluble	GBAA4092	47778244		prophage LambdaBa02, Clp protease family...	251	Drug target motif; Drug target functions	Phase 3: June 2008	2F6I	21.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04664 (show subtarget assignments)	1	purified	GBAA0996	47526275		sensor histidine kinase/response regulat...	896	putative drug target function;	Phase 4: April 2009	2C2A	10.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04668 (show subtarget assignments)	1	cloned	GBAA1327	47526592		phaP protein [Bacillus anthracis str. 'A...	174	conserved gene; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04672 (show subtarget assignments)	1	expressed	GBAA1482	47526755		sensor histidine kinase [Bacillus anthra...	603	putative drug target function;	Phase 4: April 2009	3A0R	14.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02407 (show subtarget assignments)	1	cloned	GBAA3988	47529279	acpP	acyl carrier protein [Bacillus anthracis...	77	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2X2B	81.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02406 (show subtarget assignments)	1	crystallized	GBAA2768	47528059		thioredoxin reductase, putative [Bacillu...	301	Conserved; Essential; Drug target functions	Phase 3: June 2008	3FBS	32.1%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02798 (show subtarget assignments)	1	purified	GBAA5049	47530348		carbonic anhydrase [Bacillus anthracis s...	187	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1G5C	34.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02404 (show subtarget assignments)	1	cloned	GBAA2730	47528021		neutral protease [Bacillus anthracis str...	567	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	25.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02799 (show subtarget assignments)	1	cloned	GBAA4787	47778326		hypothetical protein GBAA4787 [Bacillus ...	885	Conserved;	Phase 3: June 2008	2O6P	4.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04660 (show subtarget assignments)	1	expressed	GBAA0286	47777799		sensor histidine kinase, putative [Bacil...	314	putative drug target function;	Phase 4: April 2009	2C2A	24.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP04682
(show subtarget assignments)

1

cloned

GBAA3189

47528481

adhesion lipoprotein [Bacillus anthracis...

311

virulence factor; putative drug target function;

Phase 4: April 2009

3HH8

49.8%

Bacillus anthracis

Cell envelope

Other

IDP04683
(show subtarget assignments)

1

expressed

GBAA3269

47528557

iron-sulfur cluster-binding protein [Bac...

470

virulence factor; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Energy metabolism

Electron transport

IDP02473
(show subtarget assignments)

1

purified

GBAA3967

47529257

hslU

ATP-dependent protease ATP-binding subun...

463

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1E94

50.8%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01877
(show subtarget assignments)

1

crystallized

GBAA0080

47525336

negative regulator of genetic competence...

811

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PXI

80.1%

Bacillus anthracis

Cellular processes

DNA transformation

IDP04430
(show subtarget assignments)

1

purified

GBAA4921

47530215

sensor histidine kinase [Bacillus anthra...

484

putative drug target function;

Phase 4: April 2009

2C2A

16.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01876
(show subtarget assignments)

1

cloned

GBAA0095

47525349

secE

preprotein translocase subunit SecE [Bac...

59

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DIN

33.9%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02455
(show subtarget assignments)

1

expressed

GBAA3813

47529098

prophage LambdaBa01, thymidylate synthas...

252

Conserved; Drug target functions

Phase 3: June 2008

3AH5

24.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02489
(show subtarget assignments)

1

selected

GBAA3099

47528392

sipU

Signal peptidase I U [Bacillus anthracis...

183

Drug target motif; Drug target functions

Phase 3: June 2008

1T7D

27.8%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP04431
(show subtarget assignments)

1

cloned

GBAA5088

47530387

sensor histidine kinase [Bacillus anthra...

340

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

18.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01683
(show subtarget assignments)

1

expressed

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02453
(show subtarget assignments)

1

in_pdb
3IGJ
3HJJ

GBAA3402

47528687

maA

maltose O-acetyltransferase [Bacillus an...

187

Drug target motif; Conserved; Essential; Drug target functions

Phase 3: June 2008

3HJJ

100%

Bacillus anthracis

Cellular processes

Detoxification

IDP02456
(show subtarget assignments)

1

crystallized

GBAA3921

47529213

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

237

Conserved; Essential;

Phase 3: June 2008

2P68

38.1%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01875
(show subtarget assignments)

1

expressed

GBAA0069

47525323

pabA-1

para-aminobenzoate/anthranilate synthase...

195

Conserved; Essential; Drug target functions

Phase 3: June 2008

1QDL

45.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02454
(show subtarget assignments)

1

in_pdb
3HYL
3M49

GBAA3744

47529034

tkt-2

transketolase [Bacillus anthracis str. '...

666

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HYL

100%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP02830
(show subtarget assignments)

1

soluble

GBAA4861

47530155

pepQ-2

proline dipeptidase [Bacillus anthracis ...

365

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WY2

38.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04675
(show subtarget assignments)

1

soluble

GBAA2291

47527591

sensor histidine kinase [Bacillus anthra...

377

putative drug target function;

Phase 4: April 2009

3A0R

26.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01678
(show subtarget assignments)

1

cloned

GBAA5591

47530913

cardiolipin synthetase domain-containing...

397

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04352
(show subtarget assignments)

1

expressed

GBAA0584

47525859

sensor histidine kinase [Bacillus anthra...

487

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01813
(show subtarget assignments)

1

purified

GBAA1253

47526519

trpB

tryptophan synthase subunit beta [Bacill...

397

Conserved; Drug target functions

Phase 3: June 2008

1X1Q

63%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02335
(show subtarget assignments)

1

expressed

GBAA2583

47527873

hypothetical protein GBAA2583 [Bacillus ...

563

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3SKS

26.3%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01681
(show subtarget assignments)

1

cloned

GBAA4795

47530092

hypothetical protein GBAA4795 [Bacillus ...

572

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3AU2

37.1%

Bacillus anthracis

Unknown function

General

IDP02005
(show subtarget assignments)

1

cloned

GBAA0543

47525816

penicillin-binding domain-containing pro...

258

Drug target homolog; Involved in sporulation;

Phase 3: June 2008

2OQO

36%

Bacillus anthracis

Unknown function

General

IDP02831
(show subtarget assignments)

1

purified

GBAA4686

47529986

maf

Maf-like protein [Bacillus anthracis str...

191

Conserved; Drug target functions

Phase 3: June 2008

1EX2

53.4%

Bacillus anthracis

Cellular processes

Cell division

IDP01682
(show subtarget assignments)

1

cloned

GBAA5104

47530405

D-alanyl-D-alanine carboxypeptidase fami...

286

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01874
(show subtarget assignments)

1

cloned

GBAA0062

47525316

hypothetical protein GBAA0062 [Bacillus ...

476

Conserved;

Phase 3: June 2008

3A2K

46.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01712
(show subtarget assignments)

1

in_pdb
3EFE

GBAA2657

47551781

thiJ/pfpI family protein [Bacillus anthr...

210

CONSERVED

Phase 3: June 2008

3EFE

100%

Bacillus anthracis

N/A

IDP01881
(show subtarget assignments)

1

cloned

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04342
(show subtarget assignments)

1

cloned

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04676
(show subtarget assignments)

1

soluble

GBAA2370

47527665

dhbE

2,3-dihydroxybenzoate-AMP ligase [Bacill...

538

putative drug target function;

Phase 4: April 2009

1MD9

71.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01668
(show subtarget assignments)

1

soluble

GBAA0060

47525314

hypothetical protein GBAA0060 [Bacillus ...

160

Essential;

Phase 3: June 2008

2K4K

29.4%

Bacillus anthracis

Unknown function

General

IDP01670
(show subtarget assignments)

1

cloned

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

Phase 3: June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02328
(show subtarget assignments)

1

expressed

GBAA2548

47527837

acetyl-CoA carboxylase biotin carboxylas...

445

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N6R

51.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01672
(show subtarget assignments)

1

soluble

GBAA5133

47530438

hypothetical protein GBAA5133 [Bacillus ...

396

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1DJU

48.2%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01782
(show subtarget assignments)

1

expressed

GBAA0752

47526035

scrK

fructokinase [Bacillus anthracis str. 'A...

313

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3EWM

33.8%

Bacillus anthracis

Energy metabolism

Sugars

IDP02329
(show subtarget assignments)

1

in_pdb
3KQF

GBAA2551

47527840

enoyl-CoA hydratase [Bacillus anthracis ...

262

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3KQF

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04669
(show subtarget assignments)

1

expressed

GBAA1351

47526623

sensor histidine kinase KinD [Bacillus a...

498

putative drug target function;

Phase 4: April 2009

3D36

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01663
(show subtarget assignments)

1

purified

GBAA4696

47529995

hemC

porphobilinogen deaminase [Bacillus anth...

309

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02519
(show subtarget assignments)

1

cloned

GBAA1494

47526768

resA

thiol-disulfide oxidoreductase [Bacillus...

173

Conserved; Drug target functions

Phase 3: June 2008

1ST9

41.6%

Bacillus anthracis

Energy metabolism

Electron transport

IDP01868
(show subtarget assignments)

1

cloned

GBAA5583

47530904

ctrA

CTP synthetase [Bacillus anthracis str. ...

535

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1S1M

56.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02330
(show subtarget assignments)

1

cloned

GBAA1419

47526691

ilvC-1

ketol-acid reductoisomerase [Bacillus an...

336

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

55.7%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP01792
(show subtarget assignments)

1

expressed

GBAA0866

47777865

alsS

acetolactate synthase [Bacillus anthraci...

562

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1OZF

50.7%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04424
(show subtarget assignments)

1

expressed

GBAA4024

47529317

pyrK

dihydroorotate dehydrogenase electron tr...

259

putative drug target function;

Phase 4: April 2009

1EP3

48.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01666
(show subtarget assignments)

1

soluble

GBAA4704

47530003

clpX

ATP-dependent protease ATP-binding subun...

419

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HTE

52.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01673
(show subtarget assignments)

1

soluble

GBAA5206

47530513

M23/37 family peptidase [Bacillus anthra...

327

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

3SLU

25.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01796
(show subtarget assignments)

1

cloned

GBAA5258

47778380

cell wall surface anchor family protein ...

627

Drug target homolog; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Other

IDP01795
(show subtarget assignments)

1

expressed

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02822
(show subtarget assignments)

1

cloned

GBAA4819

47778330

infC

translation initiation factor IF-3 [Baci...

186

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TIG

40.9%

Bacillus anthracis

Protein synthesis

Translation factors

IDP04670
(show subtarget assignments)

1

expressed

GBAA1356

47526628

kinB-1

sporulation kinase B [Bacillus anthracis...

402

putative drug target function;

Phase 4: April 2009

3D36

25.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01800
(show subtarget assignments)

1

soluble

GBAA1129

47526399

S-layer protein, putative [Bacillus anth...

219

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.1%

Bacillus anthracis

Cell envelope

Surface structures

IDP01799
(show subtarget assignments)

1

soluble

GBAA1127

47526398

S-layer protein, putative [Bacillus anth...

223

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.6%

Bacillus anthracis

Cell envelope

Surface structures

IDP02439
(show subtarget assignments)

1

cloned

GBAA3892

47529180

serine protease [Bacillus anthracis str....

613

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2OXA

16.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02432
(show subtarget assignments)

1

soluble

GBAA3687

47528971

acetyl-CoA acetyltransferase [Bacillus a...

363

Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...

Phase 3: June 2008

4DD5

39.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP02528
(show subtarget assignments)

1

soluble

GBAA4405

47529699

folD

methylenetetrahydrofolate dehydrogenase/...

286

Essential; Drug target functions

Phase 3: June 2008

3P2O

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02524
(show subtarget assignments)

1

purified

GBAA1852

47527143

ilvC-2

ketol-acid reductoisomerase [Bacillus an...

335

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

56.1%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02815
(show subtarget assignments)

1

soluble

GBAA4880

47530173

argG

argininosuccinate synthase [Bacillus ant...

401

Conserved; Drug target functions

Phase 3: June 2008

1VL2

46.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02331
(show subtarget assignments)

1

selected

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01661
(show subtarget assignments)

1

soluble

GBAA4609

47529906

U32 family peptidase [Bacillus anthracis...

426

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02816
(show subtarget assignments)

1

soluble

GBAA4014

47529307

proline dipeptidase, putative [Bacillus ...

356

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3Q6D

56.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02818
(show subtarget assignments)

1

selected

GBAA4027

47529320

pyrC

dihydroorotase [Bacillus anthracis str. ...

428

Conserved; Drug target functions

Phase 3: June 2008

3MPG

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02319
(show subtarget assignments)

1

purified

GBAA1169

47526434

prsA

peptidylprolyl isomerase [Bacillus anthr...

285

Drug target motif; Drug target functions

Phase 3: June 2008

3RFW

29.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02320
(show subtarget assignments)

1

purified

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01870
(show subtarget assignments)

1

cloned

GBAA5710

47531047

serine protease [Bacillus anthracis str....

391

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GCN

31.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02325
(show subtarget assignments)

1

in_pdb
3IMF

GBAA4204

47778260

short chain dehydrogenase [Bacillus anth...

254

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3IMF

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02824
(show subtarget assignments)

1

purified

GBAA5152

47530456

gtaB

UTP-glucose-1-phosphate uridylyltransfer...

295

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2UX8

51.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04671
(show subtarget assignments)

1

soluble

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02315
(show subtarget assignments)

1

cloned

GBAA1132

47526402

aceA

isocitrate lyase [Bacillus anthracis str...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4E

71.4%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP01650
(show subtarget assignments)

1

in_pdb
3IFS

GBAA5130

47530435

pgi

glucose-6-phosphate isomerase [Bacillus ...

450

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IFS

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02807
(show subtarget assignments)

1

purified

GBAA4705

47530004

tig

trigger factor [Bacillus anthracis str. ...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T11

32.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02425
(show subtarget assignments)

1

soluble

GBAA2775

47528067

acoB

TPP-dependent acetoin dehydrogenase E1 b...

344

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1W85

43.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02427
(show subtarget assignments)

1

purified

GBAA3553

47528837

pepF-2

oligoendopeptidase F [Bacillus anthracis...

595

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QR4

37.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04666
(show subtarget assignments)

1

purified

GBAA1158

47526425

hemH-2

ferrochelatase [Bacillus anthracis str. ...

319

putative drug target function;

Phase 4: April 2009

2C8J

62.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02313
(show subtarget assignments)

1

cloned

GBAA3973

47529263

sucD

succinyl-CoA synthetase subunit alpha [B...

300

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JKJ

62.3%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP01653
(show subtarget assignments)

1

cloned

GBAA4538

47529835

dnaJ

chaperone protein dnaJ [Bacillus anthrac...

371

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LZ8

34%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02362
(show subtarget assignments)

1

cloned

GBAA1923

47777980

ldh

L-lactate dehydrogenase [Bacillus anthra...

314

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PQD

64.6%

Bacillus anthracis

Energy metabolism

Anaerobic

IDP02314
(show subtarget assignments)

1

cloned

GBAA0599

47525877

neutral protease [Bacillus anthracis str...

566

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1NPC

53%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01646
(show subtarget assignments)

1

soluble

GBAA5119

47530423

glgP

glycogen phosphorylase [Bacillus anthrac...

802

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AXR

46.5%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04665
(show subtarget assignments)

1

purified

GBAA1118

47526389

sensor histidine kinase [Bacillus anthra...

580

putative drug target function;

Phase 4: April 2009

2C2A

11.4%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04667
(show subtarget assignments)

1

cloned

GBAA1313

47526578

sensor histidine kinase [Bacillus anthra...

466

putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01639
(show subtarget assignments)

1

cloned

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01640
(show subtarget assignments)

1

purified

GBAA4357

47529653

short chain dehydrogenase/reductase fami...

264

Conserved; Essential;

Phase 3: June 2008

3P19

33.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02318
(show subtarget assignments)

1

purified

GBAA1251

47526517

trpC

indole-3-glycerol-phosphate synthase [Ba...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TSM

40.7%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02332
(show subtarget assignments)

1

purified

GBAA1462

47526735

UbiE/COQ5 family methlytransferase [Baci...

258

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UJD

22.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01675
(show subtarget assignments)

1

purified

GBAA5217

47530523

ABC transporter ATP-binding protein [Bac...

261

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2D2E

57.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02428
(show subtarget assignments)

1

expressed

GBAA3580

47528865

O-acetyltransferase, putative [Bacillus ...

188

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3VBI

99.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02826
(show subtarget assignments)

1

purified

GBAA4254

47529547

transaminase [Bacillus anthracis str. 'A...

392

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

2O1B

40.8%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01865
(show subtarget assignments)

1

in_pdb
3Q94

GBAA5580

47530901

fba-2

fructose-bisphosphate aldolase [Bacillus...

285

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3Q94

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01637
(show subtarget assignments)

1

crystallized

GBAA5111

47530413

menD

2-succinyl-6-hydroxy-2,4-cyclohexadiene-...

584

Conserved; Drug target functions

Phase 3: June 2008

2X7J

46.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02549
(show subtarget assignments)

1

soluble

GBAA0547

47525820

RNA methyltransferase [Bacillus anthraci...

162

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L8U

51.2%

Bacillus anthracis

Protein synthesis

tRNA and rRNA base modification

IDP02312
(show subtarget assignments)

1

expressed

GBAA2190

47778017

FtsK/SpoIIIE family protein [Bacillus an...

1342

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IUT

7.4%

Bacillus anthracis

Cellular processes

Cell division

IDP02157
(show subtarget assignments)

1

expressed

GBAA3961

47778228

uppS

undecaprenyl diphosphate synthase [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1F75

55.8%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02442
(show subtarget assignments)

1

soluble

GBAA4092

47778244

prophage LambdaBa02, Clp protease family...

251

Drug target motif; Drug target functions

Phase 3: June 2008

2F6I

21.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04664
(show subtarget assignments)

1

purified

GBAA0996

47526275

sensor histidine kinase/response regulat...

896

putative drug target function;

Phase 4: April 2009

2C2A

10.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP04668
(show subtarget assignments)

1

cloned

GBAA1327

47526592

phaP protein [Bacillus anthracis str. 'A...

174

conserved gene; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04672
(show subtarget assignments)

1

expressed

GBAA1482

47526755

sensor histidine kinase [Bacillus anthra...

603

putative drug target function;

Phase 4: April 2009

3A0R

14.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02407
(show subtarget assignments)

1

cloned

GBAA3988

47529279

acpP

acyl carrier protein [Bacillus anthracis...

77

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2X2B

81.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02406
(show subtarget assignments)

1

crystallized

GBAA2768

47528059

thioredoxin reductase, putative [Bacillu...

301

Conserved; Essential; Drug target functions

Phase 3: June 2008

3FBS

32.1%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02798
(show subtarget assignments)

1

purified

GBAA5049

47530348

carbonic anhydrase [Bacillus anthracis s...

187

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1G5C

34.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02404
(show subtarget assignments)

1

cloned

GBAA2730

47528021

neutral protease [Bacillus anthracis str...

567

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

25.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02799
(show subtarget assignments)

1

cloned

GBAA4787

47778326

hypothetical protein GBAA4787 [Bacillus ...

885

Conserved;

Phase 3: June 2008

2O6P

4.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04660
(show subtarget assignments)

1

expressed

GBAA0286

47777799

sensor histidine kinase, putative [Bacil...

314

putative drug target function;

Phase 4: April 2009

2C2A

24.2%

Bacillus anthracis

Regulatory functions

Protein interactions

Targets