Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00440 (show subtarget assignments)	1	purified	YPO2208	16122436	trpE	anthranilate synthase component I	521	Conserved Gene / Pathway	Phase 2: March 2008	1I7Q	79.7%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP91738 (show subtarget assignments)	8	selected	Q5YB85_STRSG	0			598	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I84	15.1%	Streptococcus sp.

IDP00013 (show subtarget assignments)	1	soluble	BA_3254	30257811		LPXTG-motif cell wall anchor domain prot...	372	Drug Target Homolog	Phase 1: October 2007	1I84	18.3%	Bacillus anthracis	Cell envelope	Other

IDP00476 (show subtarget assignments)	1	soluble	YPO0063	161486895		hypothetical protein YPO0063	456	Virulence Associated Factor	Phase 2: March 2008	1I84	13.4%	Yersinia pestis	Cell envelope	Other

IDP05358 (show subtarget assignments)	1	cloned	BA_0685	30254284		conserved hypothetical protein [Bacillus...	420	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1I84	12.1%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP91741 (show subtarget assignments)	8	selected	Q6V4L4_STRPY	0			397	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I84	22.4%	Streptococcus pyogenes

IDP91672 (show subtarget assignments)	8	selected	ARP4_STRPY	0			386	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1I84	19.7%	Streptococcus pyogenes

IDP01803 (show subtarget assignments)	1	soluble	CBU_0646	29541247	ribE	riboflavin synthase, alpha subunit [Coxi...	202	Conserved; Drug target functions	Phase 3: June 2008	1I8D	37.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04105 (show subtarget assignments)	1	purified	YPO2391	115348093	ribC	riboflavin synthase alpha chain [Yersini...	218	conserved gene; putative drug target function;	Phase 4: April 2009	1I8D	74.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00918 (show subtarget assignments)	1	soluble	STM0372	16763752	hemB	delta-aminolevulinic acid dehydratase	324	Conserved Gene / Pathway	Phase 2: March 2008	1I8J	93.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01966 (show subtarget assignments)	1	expressed	Cj1439c	15792757	glf	UDP-galactopyranose mutase [Campylobacte...	368	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1I8T	59.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91376 (show subtarget assignments)	8	soluble	VV1_1694	27365055		hypothetical protein VV1_1694 [Vibrio vu...	151	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1IB8	29.8%	Vibrio vulnificus

IDP02394 (show subtarget assignments)	1	cloned	YPO1633	16121901	phoQ	sensor protein PhoQ [Yersinia pestis CO9...	484	Conserved; CD; Drug target functions	Phase 3: June 2008	1ID0	20.9%	Yersinia pestis	Regulatory functions	Other

IDP05142 (show subtarget assignments)	1	cloned	BAS2027	49185038	-	isoleucyl-tRNA synthetase [Bacillus anth...	1033	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ILE	38.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP91434 (show subtarget assignments)	8	soluble	VV1_0486	27363950		ribosome-associated protein Y [Vibrio vu...	107	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1IMU	50.5%	Vibrio vulnificus

IDP02236 (show subtarget assignments)	1	cloned	FTT1108	56708186		rRNA methyltransferase [Francisella tula...	250	Drug Target	Phase 3: June 2008	1IPA	29.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP04340 (show subtarget assignments)	1	cloned	BAS0122	49183156		50S ribosomal protein L5 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1IQ4	85.5%	Bacillus anthracis

IDP02110 (show subtarget assignments)	1	expressed	STM3820	16767105		putative cytochrome c peroxidase [Salmon...	466	Conserved; Drug target functions	Phase 3: June 2008	1IQC	29.4%	Salmonella enterica	Cellular processes	Detoxification

IDP91700 (show subtarget assignments)	8	selected	NP_002791	4506205	PSMB9	proteasome subunit beta type-9 proprotei...	219	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1IRU	55.7%	Homo sapiens

IDP04731 (show subtarget assignments)	1	purified	BAS3675	49186674		ribosome recycling factor [Bacillus anth...	185	Proposed to be essential proteins	Phase 4: April 2009	1IS1	50.8%	Bacillus anthracis

IDP91008 (show subtarget assignments)	8	soluble	y1951	22125843	sodB	superoxide dismutase [Yersinia pestis KI...	206	other biological interest / iron-regulated oxidative stress enzyme	Community Requests	1ISA	75.2%	Yersinia pestis

IDP04654 (show subtarget assignments)	1	purified	FTT1526c	56708560	idh	isocitrate dehydrogenase [Francisella tu...	747	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ITW	62.7%	Francisella tularensis

IDP05654 (show subtarget assignments)	1	soluble	lmo0105	16802153	-	hypothetical protein lmo0105 [Listeria m...	756	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1ITX	19.4%	Listeria monocytogenes	Energy metabolism: ATP-proton motive force interconversion

IDP01934 (show subtarget assignments)	1	soluble	GBAA0385	47525656		chitinase B [Bacillus anthracis str. 'Am...	674	Drug target motif; Drug target functions	Phase 3: June 2008	1ITX	37.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP05198 (show subtarget assignments)	1	cloned	CD1433	126699037		putative bifunctional protein: peroxired...	709	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1ITX	17.3%	Clostridium difficile	Cellular processes: Detoxification

IDP02600 (show subtarget assignments)	1	expressed	STM2279	16765606	yfaE	2Fe-2S ferredoxin YfaE [Salmonella typhi...	84	Conserved; Drug target functions	Phase 3: June 2008	1IUE	37.2%	Salmonella enterica	Unknown function	General

IDP00455 (show subtarget assignments)	1	soluble	YPO3080	16123257	tesA	multifunctional acyl-CoA thioesterase I ...	212	Conserved Gene / Pathway	Phase 2: March 2008	1IVN	60.4%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02351 (show subtarget assignments)	1	cloned	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP04208 (show subtarget assignments)	1	purified	CPF_2958	110799195	purA	adenylosuccinate synthetase [Clostridium...	428	conserved gene; putative drug target function;	Phase 4: April 2009	1IWE	47.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04529 (show subtarget assignments)	1	soluble	STM2481_1_1037	16765801	acrD	aminoglycoside/multidrug efflux system [...	1037	Salmonella essential protein	Phase 4: April 2009	1IWG	66.2%	Salmonella enterica

IDP02066 (show subtarget assignments)	1	cloned	YPO1377	16121657	lolA	outer-membrane lipoprotein carrier prote...	202	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1IWL	66.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP01447 (show subtarget assignments)	1	purified	VC2181	15642180	lolB	outer membrane lipoprotein LolB	211	Conserved Gene / Pathway	Phase 2: March 2008	1IWM	30.3%	Vibrio cholerae	Cell envelope	Other

IDP00500 (show subtarget assignments)	1	purified	YPO1784	16122038		putative copper resistance protein	128	Conserved Gene / Pathway	Phase 2: March 2008	1IX2	31.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP05236 (show subtarget assignments)	1	purified	lmo1533	16803573	ruvA	hypothetical protein lmo1533 [Listeria m...	201	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	34.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05336 (show subtarget assignments)	1	soluble	Cj0799c	6968240	ruvA	hypothetical protein Cj0794 [Campylobact...	183	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	32.5%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP02814 (show subtarget assignments)	1	cloned	FTT0709	56707828	eno	enolase (2-phosphoglycerate dehydratase)...	456	Conserved; Drug target functions	Phase 3: June 2008	1IYX	60.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP05136 (show subtarget assignments)	1	purified	CD0886	126698463		putative alpha-amylase [Clostridium diff...	621	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1IZJ	30%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00774 (show subtarget assignments)	1	cloned	SACOL0597	57285613		chaperone protein HchA	292	Drug Target Function	Phase 2: March 2008	1IZY	54.1%	Staphylococcus aureus	Hypothetical proteins	Conserved

IDP00979 (show subtarget assignments)	1	purified	STM1953	16765291	yedO	D-cysteine desulfhydrase	328	Conserved Gene / Pathway	Phase 2: March 2008	1J0A	38.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP05063 (show subtarget assignments)	1	purified	CD2190	126699806		cyclomaltodextrinase (maltogenic alpha-a...	627	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1J0H	47.4%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01138 (show subtarget assignments)	1	purified	BA_4230	30258733		alpha-amylase	586	Drug Target Function	Phase 2: March 2008	1J0H	61%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP90768 (show subtarget assignments)	8	purified	Cj0665c	15792020	argG	argininosuccinate synthase [Campylobacte...	406	Predicted Essential	Community Requests	1J1Z	57.9%	Campylobacter jejuni

IDP02669 (show subtarget assignments)	1	purified	GBAA1568	50196927	aspB	aspartate aminotransferase [Bacillus ant...	395	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J32	45.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP90661 (show subtarget assignments)	8	purified	Q9KSL9	33301117		RecName: Full=Nicotinate-nucleotide--dim...	341	Predicted Essential	Community Requests	1J33	45.2%	Vibrio cholerae

IDP01623 (show subtarget assignments)	1	cloned	GBAA5019	47530321	pckA	phosphoenolpyruvate carboxykinase [Bacil...	528	Conserved; Essential; Drug target functions	Phase 3: June 2008	1J3B	52.8%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00522 (show subtarget assignments)	1	soluble	YPO3423	16123572	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	183	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	62.3%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00855 (show subtarget assignments)	1	purified	STM0146	16763536	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	187	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	89.8%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP01347 (show subtarget assignments)	1	purified	VC2421	15642418		N-acetyl-anhydromuranmyl-L-alanine amida...	181	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	63%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP02161 (show subtarget assignments)	1	soluble	FTT0162	56707332	ampD	N-acetyl-anhydromuranmyl-L-alanine amida...	174	Drug Target	Phase 3: June 2008	1J3G	47.7%	Francisella tularensis	Cellular processes	Toxin production and resistance

IDP90856 (show subtarget assignments)	8	crystallized	Cj0442	15791809	fabF	3-oxoacyl-(acyl carrier protein) synthas...	404	Predicted Essential	Community Requests	1J3N	52.7%	Campylobacter jejuni

IDP00485 (show subtarget assignments)	1	purified	YPO1455	16121730		putative beta-ketoacyl-[acyl-carrier-pro...	427	Drug Target Function	Phase 2: March 2008	1J3N	32.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP05344 (show subtarget assignments)	1	purified	Z1549	12514420		putative beta-ketoacyl-[acyl carrier pro...	852	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1J3N	18.2%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP91247 (show subtarget assignments)	8	selected	HP0558	2313676		beta ketoacyl-acyl carrier protein synth...	412	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1J3N	49.4%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP02640 (show subtarget assignments)	1	purified	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP00189 (show subtarget assignments)	1	purified	YPO0845	16121153	-	ThiJ/PfpI-family thiamine biogenesis pro...	192	Virulence	Phase 1: October 2007	1J42	29.2%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP91723 (show subtarget assignments)	8	selected	NP_112552	14165435	HNRNPK	heterogeneous nuclear ribonucleoprotein ...	463	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1J5K	18.6%	Homo sapiens

IDP05557 (show subtarget assignments)	1	expressed	lmo1459	16803499	glyQ	glycyl-tRNA synthetase subunit alpha [Li...	263	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1J5W	54.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP01124 (show subtarget assignments)	1	soluble	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01330 (show subtarget assignments)	1	purified	VC0557	15640579		S-ribosylhomocysteinase	172	Conserved Gene / Pathway	Phase 2: March 2008	1J6W	71.5%	Vibrio cholerae	Cellular processes	Other

IDP04226 (show subtarget assignments)	1	cloned	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP91795 (show subtarget assignments)	8	purified	CAA24789	47034		unnamed protein product [Enterococcus fa...	264	other biological interest / Kinase	Community Requests	1J7I	100%	Enterococcus faecalis

IDP04096 (show subtarget assignments)	1	purified	YPO2010	115347732	ychF	conserved hypothetical protein [Yersinia...	363	drug target; virulence factor; conserved gene;	Phase 4: April 2009	1JAL	79.6%	Yersinia pestis	Unknown function	General

IDP02675 (show subtarget assignments)	1	expressed	CBU_1842	29542398		GTP-binding protein YchF [Coxiella burne...	363	Conserved; Drug target functions	Phase 3: June 2008	1JAL	65.3%	Coxiella burnetii	Unknown function	General

IDP01631 (show subtarget assignments)	1	soluble	CBU_2024	29542577		cystathionine beta-synthase, putative [C...	316	Conserved; Drug target functions	Phase 3: June 2008	1JBQ	60.9%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP01231 (show subtarget assignments)	1	purified	BA_4684	30259179	mreB	rod shape-determining protein MreB	339	Drug Target Function	Phase 2: March 2008	1JCE	52.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01152 (show subtarget assignments)	1	purified	BA_5520	30259980	mbl	mbl protein	333	Conserved Gene / Pathway	Phase 2: March 2008	1JCE	50.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04193 (show subtarget assignments)	1	cloned	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP05022 (show subtarget assignments)	1	cloned	CD1145	126698740	mreB2	rod shape-determining protein MreB [Clos...	353	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JCE	54.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05051 (show subtarget assignments)	1	cloned	CD0127	126697699	mreB1	rod shape-determining protein Mbl [Clost...	339	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JCE	52.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01090 (show subtarget assignments)	0	work_stopped	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02118 (show subtarget assignments)	1	cloned	STM4388	16767634	sgaE	L-ribulose-5-phosphate 4-epimerase [Salm...	228	Conserved; Drug target functions	Phase 3: June 2008	1JDI	60%	Salmonella enterica	Energy metabolism	Sugars

IDP01052 (show subtarget assignments)	1	expressed	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90815 (show subtarget assignments)	8	selected	S2169	30063443	cobT	nicotinate-nucleotide--dimethylbenzimida...	359	Predicted Essential	Community Requests	1JH8	76%	Shigella flexneri

IDP00210 (show subtarget assignments)	1	crystallized	YPO0314	16120652	lexA	LexA repressor	202	Virulence	Phase 1: October 2007	1JHF	91.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02112 (show subtarget assignments)	1	cloned	FTT1024c	56708113	yhbG	ABC transporter, ATP-binding protein [Fr...	243	Conserved; Drug target functions	Phase 3: June 2008	1JI0	34.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01465 (show subtarget assignments)	1	soluble	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01365 (show subtarget assignments)	1	soluble	VC0201	15640231		iron(III) ABC transporter, ATP-binding p...	285	Conserved Gene / Pathway	Phase 2: March 2008	1JJ7	28.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01835 (show subtarget assignments)	1	cloned	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00333 (show subtarget assignments)	1	crystallized	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02800 (show subtarget assignments)	1	soluble	GBAA4828	47530124	coaE	dephospho-CoA kinase [Bacillus anthracis...	200	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JJV	43.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90715 (show subtarget assignments)	8	expressed	Cj0534	15791895	sucD	succinyl-CoA synthase, alpha subunit [Ca...	289	Predicted Essential	Community Requests	1JKJ	58.1%	Campylobacter jejuni

IDP02313 (show subtarget assignments)	1	cloned	GBAA3973	47529263	sucD	succinyl-CoA synthetase subunit alpha [B...	300	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JKJ	62.3%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04040 (show subtarget assignments)	1	cloned	CPF_1068	110800949	cotJC	spore coat protein CotJC [Clostridium pe...	188	conserved gene; putative drug target function;	Phase 4: April 2009	1JKU	34.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05274 (show subtarget assignments)	1	soluble	lmo1880	16803919	-	hypothetical protein lmo1880 [Listeria m...	133	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JL2	33.8%	Listeria monocytogenes	Transcription: Degradation of RNA

IDP01613 (show subtarget assignments)	1	purified	STM1927	16765269	yecG	universal stress protein UspC [Salmonell...	142	Conserved; Drug target functions	Phase 3: June 2008	1JMV	35.2%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP01061 (show subtarget assignments)	1	purified	STM3591	16766877	uspA	universal stress protein A	144	Conserved Gene / Pathway	Phase 2: March 2008	1JMV	66.7%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP91059 (show subtarget assignments)	8	soluble	FTT_1472c	56708512	ppiC	peptidyl-prolyl cis-trans isomerase [Fra...	92	virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...	Community Requests	1JNS	47.8%	Francisella tularensis

IDP01326 (show subtarget assignments)	1	soluble	VCA0953	15601706		peptidyl-prolyl cis-trans isomerase C	92	Conserved Gene / Pathway	Phase 2: March 2008	1JNS	65.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP90511 (show subtarget assignments)	8	purified	Q9KPV6	42560015		RecName: Full=Undecaprenyl pyrophosphate...	250	Predicted Essential	Community Requests	1JP3	56%	Vibrio cholerae

IDP04086 (show subtarget assignments)	1	expressed	VC2256	15642254		undecaprenyl diphosphate synthase [Vibri...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	54.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01815 (show subtarget assignments)	1	soluble	CBU_1382	29541947	uppS	undecaprenyl diphosphate synthase [Coxie...	237	Conserved; Drug target functions	Phase 3: June 2008	1JP3	49.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04452 (show subtarget assignments)	1	purified	YPO1049	42560001		RecName: Full=Undecaprenyl pyrophosphate...	252	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1JP3	76.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01822 (show subtarget assignments)	1	cloned	FTT0317	56707470	uppS	undecaprenyl pyrophosphate synthetase [F...	257	Conserved; Drug target functions	Phase 3: June 2008	1JP3	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01895 (show subtarget assignments)	1	soluble	STM1681	16765024	ycjG	putative chloromuconate cycloisomerase [...	321	Conserved; Drug target functions	Phase 3: June 2008	1JPD	85.4%	Salmonella enterica	Energy metabolism	Other

IDP91277 (show subtarget assignments)	8	selected	NT05BA4403	49181145		conserved hypothetical protein [Bacillus...	336	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1JQJ	17.3%	Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP90919 (show subtarget assignments)	8	expressed	YPO2608	16122821	holA	DNA polymerase III subunit delta [Yersin...	344	Predicted Essential	Community Requests	1JQJ	71.5%	Yersinia pestis

IDP90848 (show subtarget assignments)	8	cloned	VC0953	15640969	holA	DNA polymerase III subunit delta [Vibrio...	342	Predicted Essential	Community Requests	1JQJ	49.1%	Vibrio cholerae

IDP04212 (show subtarget assignments)	1	cloned	STM0646_1_343	16764023	holA	DNA polymerase III subunit delta [Salmon...	343	Salmonella essential protein	Phase 4: April 2009	1JQJ	89.8%	Salmonella enterica

IDP90616 (show subtarget assignments)	8	selected	VC1054	15641067		DNA polymerase III subunits gamma and ta...	692	Predicted Essential	Community Requests	1JR3	34.5%	Vibrio cholerae

IDP90891 (show subtarget assignments)	8	cloned	YPO3122	16123287	dnaX	DNA polymerase III subunits gamma and ta...	658	Predicted Essential	Community Requests	1JR3	46.7%	Yersinia pestis

IDP00440
(show subtarget assignments)

1

purified

YPO2208

16122436

trpE

anthranilate synthase component I

521

Conserved Gene / Pathway

Phase 2: March 2008

1I7Q

79.7%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP91738
(show subtarget assignments)

8

selected

Q5YB85_STRSG

0

598

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I84

15.1%

Streptococcus sp.

IDP00013
(show subtarget assignments)

1

soluble

BA_3254

30257811

LPXTG-motif cell wall anchor domain prot...

372

Drug Target Homolog

Phase 1: October 2007

1I84

18.3%

Bacillus anthracis

Cell envelope

Other

IDP00476
(show subtarget assignments)

1

soluble

YPO0063

161486895

hypothetical protein YPO0063

456

Virulence Associated Factor

Phase 2: March 2008

1I84

13.4%

Yersinia pestis

Cell envelope

Other

IDP05358
(show subtarget assignments)

1

cloned

BA_0685

30254284

conserved hypothetical protein [Bacillus...

420

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1I84

12.1%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP91741
(show subtarget assignments)

8

selected

Q6V4L4_STRPY

0

397

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I84

22.4%

Streptococcus pyogenes

IDP91672
(show subtarget assignments)

8

selected

ARP4_STRPY

0

386

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1I84

19.7%

Streptococcus pyogenes

IDP01803
(show subtarget assignments)

1

soluble

CBU_0646

29541247

ribE

riboflavin synthase, alpha subunit [Coxi...

202

Conserved; Drug target functions

Phase 3: June 2008

1I8D

37.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04105
(show subtarget assignments)

1

purified

YPO2391

115348093

ribC

riboflavin synthase alpha chain [Yersini...

218

conserved gene; putative drug target function;

Phase 4: April 2009

1I8D

74.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00918
(show subtarget assignments)

1

soluble

STM0372

16763752

hemB

delta-aminolevulinic acid dehydratase

324

Conserved Gene / Pathway

Phase 2: March 2008

1I8J

93.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01966
(show subtarget assignments)

1

expressed

Cj1439c

15792757

glf

UDP-galactopyranose mutase [Campylobacte...

368

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1I8T

59.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91376
(show subtarget assignments)

8

soluble

VV1_1694

27365055

hypothetical protein VV1_1694 [Vibrio vu...

151

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1IB8

29.8%

Vibrio vulnificus

IDP02394
(show subtarget assignments)

1

cloned

YPO1633

16121901

phoQ

sensor protein PhoQ [Yersinia pestis CO9...

484

Conserved; CD; Drug target functions

Phase 3: June 2008

1ID0

20.9%

Yersinia pestis

Regulatory functions

Other

IDP05142
(show subtarget assignments)

1

cloned

BAS2027

49185038

-

isoleucyl-tRNA synthetase [Bacillus anth...

1033

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ILE

38.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP91434
(show subtarget assignments)

8

soluble

VV1_0486

27363950

ribosome-associated protein Y [Vibrio vu...

107

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1IMU

50.5%

Vibrio vulnificus

IDP02236
(show subtarget assignments)

1

cloned

FTT1108

56708186

rRNA methyltransferase [Francisella tula...

250

Drug Target

Phase 3: June 2008

1IPA

29.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04340
(show subtarget assignments)

1

cloned

BAS0122

49183156

50S ribosomal protein L5 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1IQ4

85.5%

Bacillus anthracis

IDP02110
(show subtarget assignments)

1

expressed

STM3820

16767105

putative cytochrome c peroxidase [Salmon...

466

Conserved; Drug target functions

Phase 3: June 2008

1IQC

29.4%

Salmonella enterica

Cellular processes

Detoxification

IDP91700
(show subtarget assignments)

8

selected

NP_002791

4506205

PSMB9

proteasome subunit beta type-9 proprotei...

219

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1IRU

55.7%

Homo sapiens

IDP04731
(show subtarget assignments)

1

purified

BAS3675

49186674

ribosome recycling factor [Bacillus anth...

185

Proposed to be essential proteins

Phase 4: April 2009

1IS1

50.8%

Bacillus anthracis

IDP91008
(show subtarget assignments)

8

soluble

y1951

22125843

sodB

superoxide dismutase [Yersinia pestis KI...

206

other biological interest / iron-regulated oxidative stress enzyme

Community Requests

1ISA

75.2%

Yersinia pestis

IDP04654
(show subtarget assignments)

1

purified

FTT1526c

56708560

idh

isocitrate dehydrogenase [Francisella tu...

747

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ITW

62.7%

Francisella tularensis

IDP05654
(show subtarget assignments)

1

soluble

lmo0105

16802153

-

hypothetical protein lmo0105 [Listeria m...

756

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1ITX

19.4%

Listeria monocytogenes

Energy metabolism: ATP-proton motive force interconversion

IDP01934
(show subtarget assignments)

1

soluble

GBAA0385

47525656

chitinase B [Bacillus anthracis str. 'Am...

674

Drug target motif; Drug target functions

Phase 3: June 2008

1ITX

37.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP05198
(show subtarget assignments)

1

cloned

CD1433

126699037

putative bifunctional protein: peroxired...

709

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1ITX

17.3%

Clostridium difficile

Cellular processes: Detoxification

IDP02600
(show subtarget assignments)

1

expressed

STM2279

16765606

yfaE

2Fe-2S ferredoxin YfaE [Salmonella typhi...

84

Conserved; Drug target functions

Phase 3: June 2008

1IUE

37.2%

Salmonella enterica

Unknown function

General

IDP00455
(show subtarget assignments)

1

soluble

YPO3080

16123257

tesA

multifunctional acyl-CoA thioesterase I ...

212

Conserved Gene / Pathway

Phase 2: March 2008

1IVN

60.4%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02351
(show subtarget assignments)

1

cloned

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP04208
(show subtarget assignments)

1

purified

CPF_2958

110799195

purA

adenylosuccinate synthetase [Clostridium...

428

conserved gene; putative drug target function;

Phase 4: April 2009

1IWE

47.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04529
(show subtarget assignments)

1

soluble

STM2481_1_1037

16765801

acrD

aminoglycoside/multidrug efflux system [...

1037

Salmonella essential protein

Phase 4: April 2009

1IWG

66.2%

Salmonella enterica

IDP02066
(show subtarget assignments)

1

cloned

YPO1377

16121657

lolA

outer-membrane lipoprotein carrier prote...

202

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1IWL

66.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP01447
(show subtarget assignments)

1

purified

VC2181

15642180

lolB

outer membrane lipoprotein LolB

211

Conserved Gene / Pathway

Phase 2: March 2008

1IWM

30.3%

Vibrio cholerae

Cell envelope

Other

IDP00500
(show subtarget assignments)

1

purified

YPO1784

16122038

putative copper resistance protein

128

Conserved Gene / Pathway

Phase 2: March 2008

1IX2

31.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP05236
(show subtarget assignments)

1

purified

lmo1533

16803573

ruvA

hypothetical protein lmo1533 [Listeria m...

201

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

34.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05336
(show subtarget assignments)

1

soluble

Cj0799c

6968240

ruvA

hypothetical protein Cj0794 [Campylobact...

183

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

32.5%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP02814
(show subtarget assignments)

1

cloned

FTT0709

56707828

eno

enolase (2-phosphoglycerate dehydratase)...

456

Conserved; Drug target functions

Phase 3: June 2008

1IYX

60.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP05136
(show subtarget assignments)

1

purified

CD0886

126698463

putative alpha-amylase [Clostridium diff...

621

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1IZJ

30%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00774
(show subtarget assignments)

1

cloned

SACOL0597

57285613

chaperone protein HchA

292

Drug Target Function

Phase 2: March 2008

1IZY

54.1%

Staphylococcus aureus

Hypothetical proteins

Conserved

IDP00979
(show subtarget assignments)

1

purified

STM1953

16765291

yedO

D-cysteine desulfhydrase

328

Conserved Gene / Pathway

Phase 2: March 2008

1J0A

38.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP05063
(show subtarget assignments)

1

purified

CD2190

126699806

cyclomaltodextrinase (maltogenic alpha-a...

627

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1J0H

47.4%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01138
(show subtarget assignments)

1

purified

BA_4230

30258733

alpha-amylase

586

Drug Target Function

Phase 2: March 2008

1J0H

61%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP90768
(show subtarget assignments)

8

purified

Cj0665c

15792020

argG

argininosuccinate synthase [Campylobacte...

406

Predicted Essential

Community Requests

1J1Z

57.9%

Campylobacter jejuni

IDP02669
(show subtarget assignments)

1

purified

GBAA1568

50196927

aspB

aspartate aminotransferase [Bacillus ant...

395

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J32

45.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP90661
(show subtarget assignments)

8

purified

Q9KSL9

33301117

RecName: Full=Nicotinate-nucleotide--dim...

341

Predicted Essential

Community Requests

1J33

45.2%

Vibrio cholerae

IDP01623
(show subtarget assignments)

1

cloned

GBAA5019

47530321

pckA

phosphoenolpyruvate carboxykinase [Bacil...

528

Conserved; Essential; Drug target functions

Phase 3: June 2008

1J3B

52.8%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00522
(show subtarget assignments)

1

soluble

YPO3423

16123572

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

183

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

62.3%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00855
(show subtarget assignments)

1

purified

STM0146

16763536

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

187

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

89.8%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP01347
(show subtarget assignments)

1

purified

VC2421

15642418

N-acetyl-anhydromuranmyl-L-alanine amida...

181

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

63%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP02161
(show subtarget assignments)

1

soluble

FTT0162

56707332

ampD

N-acetyl-anhydromuranmyl-L-alanine amida...

174

Drug Target

Phase 3: June 2008

1J3G

47.7%

Francisella tularensis

Cellular processes

Toxin production and resistance

IDP90856
(show subtarget assignments)

8

crystallized

Cj0442

15791809

fabF

3-oxoacyl-(acyl carrier protein) synthas...

404

Predicted Essential

Community Requests

1J3N

52.7%

Campylobacter jejuni

IDP00485
(show subtarget assignments)

1

purified

YPO1455

16121730

putative beta-ketoacyl-[acyl-carrier-pro...

427

Drug Target Function

Phase 2: March 2008

1J3N

32.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP05344
(show subtarget assignments)

1

purified

Z1549

12514420

putative beta-ketoacyl-[acyl carrier pro...

852

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1J3N

18.2%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP91247
(show subtarget assignments)

8

selected

HP0558

2313676

beta ketoacyl-acyl carrier protein synth...

412

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1J3N

49.4%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP02640
(show subtarget assignments)

1

purified

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP00189
(show subtarget assignments)

1

purified

YPO0845

16121153

-

ThiJ/PfpI-family thiamine biogenesis pro...

192

Virulence

Phase 1: October 2007

1J42

29.2%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP91723
(show subtarget assignments)

8

selected

NP_112552

14165435

HNRNPK

heterogeneous nuclear ribonucleoprotein ...

463

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1J5K

18.6%

Homo sapiens

IDP05557
(show subtarget assignments)

1

expressed

lmo1459

16803499

glyQ

glycyl-tRNA synthetase subunit alpha [Li...

263

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1J5W

54.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP01124
(show subtarget assignments)

1

soluble

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01330
(show subtarget assignments)

1

purified

VC0557

15640579

S-ribosylhomocysteinase

172

Conserved Gene / Pathway

Phase 2: March 2008

1J6W

71.5%

Vibrio cholerae

Cellular processes

Other

IDP04226
(show subtarget assignments)

1

cloned

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

IDP91795
(show subtarget assignments)

8

purified

CAA24789

47034

unnamed protein product [Enterococcus fa...

264

other biological interest / Kinase

Community Requests

1J7I

100%

Enterococcus faecalis

IDP04096
(show subtarget assignments)

1

purified

YPO2010

115347732

ychF

conserved hypothetical protein [Yersinia...

363

drug target; virulence factor; conserved gene;

Phase 4: April 2009

1JAL

79.6%

Yersinia pestis

Unknown function

General

IDP02675
(show subtarget assignments)

1

expressed

CBU_1842

29542398

GTP-binding protein YchF [Coxiella burne...

363

Conserved; Drug target functions

Phase 3: June 2008

1JAL

65.3%

Coxiella burnetii

Unknown function

General

IDP01631
(show subtarget assignments)

1

soluble

CBU_2024

29542577

cystathionine beta-synthase, putative [C...

316

Conserved; Drug target functions

Phase 3: June 2008

1JBQ

60.9%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP01231
(show subtarget assignments)

1

purified

BA_4684

30259179

mreB

rod shape-determining protein MreB

339

Drug Target Function

Phase 2: March 2008

1JCE

52.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01152
(show subtarget assignments)

1

purified

BA_5520

30259980

mbl

mbl protein

333

Conserved Gene / Pathway

Phase 2: March 2008

1JCE

50.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04193
(show subtarget assignments)

1

cloned

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP05022
(show subtarget assignments)

1

cloned

CD1145

126698740

mreB2

rod shape-determining protein MreB [Clos...

353

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JCE

54.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05051
(show subtarget assignments)

1

cloned

CD0127

126697699

mreB1

rod shape-determining protein Mbl [Clost...

339

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JCE

52.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01090
(show subtarget assignments)

0

work_stopped

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02118
(show subtarget assignments)

1

cloned

STM4388

16767634

sgaE

L-ribulose-5-phosphate 4-epimerase [Salm...

228

Conserved; Drug target functions

Phase 3: June 2008

1JDI

60%

Salmonella enterica

Energy metabolism

Sugars

IDP01052
(show subtarget assignments)

1

expressed

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90815
(show subtarget assignments)

8

selected

S2169

30063443

cobT

nicotinate-nucleotide--dimethylbenzimida...

359

Predicted Essential

Community Requests

1JH8

76%

Shigella flexneri

IDP00210
(show subtarget assignments)

1

crystallized

YPO0314

16120652

lexA

LexA repressor

202

Virulence

Phase 1: October 2007

1JHF

91.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02112
(show subtarget assignments)

1

cloned

FTT1024c

56708113

yhbG

ABC transporter, ATP-binding protein [Fr...

243

Conserved; Drug target functions

Phase 3: June 2008

1JI0

34.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01465
(show subtarget assignments)

1

soluble

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01365
(show subtarget assignments)

1

soluble

VC0201

15640231

iron(III) ABC transporter, ATP-binding p...

285

Conserved Gene / Pathway

Phase 2: March 2008

1JJ7

28.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01835
(show subtarget assignments)

1

cloned

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00333
(show subtarget assignments)

1

crystallized

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02800
(show subtarget assignments)

1

soluble

GBAA4828

47530124

coaE

dephospho-CoA kinase [Bacillus anthracis...

200

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JJV

43.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90715
(show subtarget assignments)

8

expressed

Cj0534

15791895

sucD

succinyl-CoA synthase, alpha subunit [Ca...

289

Predicted Essential

Community Requests

1JKJ

58.1%

Campylobacter jejuni

IDP02313
(show subtarget assignments)

1

cloned

GBAA3973

47529263

sucD

succinyl-CoA synthetase subunit alpha [B...

300

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JKJ

62.3%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04040
(show subtarget assignments)

1

cloned

CPF_1068

110800949

cotJC

spore coat protein CotJC [Clostridium pe...

188

conserved gene; putative drug target function;

Phase 4: April 2009

1JKU

34.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05274
(show subtarget assignments)

1

soluble

lmo1880

16803919

-

hypothetical protein lmo1880 [Listeria m...

133

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JL2

33.8%

Listeria monocytogenes

Transcription: Degradation of RNA

IDP01613
(show subtarget assignments)

1

purified

STM1927

16765269

yecG

universal stress protein UspC [Salmonell...

142

Conserved; Drug target functions

Phase 3: June 2008

1JMV

35.2%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP01061
(show subtarget assignments)

1

purified

STM3591

16766877

uspA

universal stress protein A

144

Conserved Gene / Pathway

Phase 2: March 2008

1JMV

66.7%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP91059
(show subtarget assignments)

8

soluble

FTT_1472c

56708512

ppiC

peptidyl-prolyl cis-trans isomerase [Fra...

92

virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...

Community Requests

1JNS

47.8%

Francisella tularensis

IDP01326
(show subtarget assignments)

1

soluble

VCA0953

15601706

peptidyl-prolyl cis-trans isomerase C

92

Conserved Gene / Pathway

Phase 2: March 2008

1JNS

65.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP90511
(show subtarget assignments)

8

purified

Q9KPV6

42560015

RecName: Full=Undecaprenyl pyrophosphate...

250

Predicted Essential

Community Requests

1JP3

56%

Vibrio cholerae

IDP04086
(show subtarget assignments)

1

expressed

VC2256

15642254

undecaprenyl diphosphate synthase [Vibri...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

54.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01815
(show subtarget assignments)

1

soluble

CBU_1382

29541947

uppS

undecaprenyl diphosphate synthase [Coxie...

237

Conserved; Drug target functions

Phase 3: June 2008

1JP3

49.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04452
(show subtarget assignments)

1

purified

YPO1049

42560001

RecName: Full=Undecaprenyl pyrophosphate...

252

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1JP3

76.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01822
(show subtarget assignments)

1

cloned

FTT0317

56707470

uppS

undecaprenyl pyrophosphate synthetase [F...

257

Conserved; Drug target functions

Phase 3: June 2008

1JP3

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01895
(show subtarget assignments)

1

soluble

STM1681

16765024

ycjG

putative chloromuconate cycloisomerase [...

321

Conserved; Drug target functions

Phase 3: June 2008

1JPD

85.4%

Salmonella enterica

Energy metabolism

Other

IDP91277
(show subtarget assignments)

8

selected

NT05BA4403

49181145

conserved hypothetical protein [Bacillus...

336

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1JQJ

17.3%

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP90919
(show subtarget assignments)

8

expressed

YPO2608

16122821

holA

DNA polymerase III subunit delta [Yersin...

344

Predicted Essential

Community Requests

1JQJ

71.5%

Yersinia pestis

IDP90848
(show subtarget assignments)

8

cloned

VC0953

15640969

holA

DNA polymerase III subunit delta [Vibrio...

342

Predicted Essential

Community Requests

1JQJ

49.1%

Vibrio cholerae

IDP04212
(show subtarget assignments)

1

cloned

STM0646_1_343

16764023

holA

DNA polymerase III subunit delta [Salmon...

343

Salmonella essential protein

Phase 4: April 2009

1JQJ

89.8%

Salmonella enterica

IDP90616
(show subtarget assignments)

8

selected

VC1054

15641067

DNA polymerase III subunits gamma and ta...

692

Predicted Essential

Community Requests

1JR3

34.5%

Vibrio cholerae

IDP90891
(show subtarget assignments)

8

cloned

YPO3122

16123287

dnaX

DNA polymerase III subunits gamma and ta...

658

Predicted Essential

Community Requests

1JR3

46.7%

Yersinia pestis