Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05199 (show subtarget assignments)	1	cloned	CD1556	126699160		putative polysaccharide deacetylase [Clo...	277	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	22.7%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00773 (show subtarget assignments)	1	purified	SACOL0569	57285587		ATP:guanido phosphotransferase	335	Drug Target Function	Phase 2: March 2008	3L2D	22.7%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP05093 (show subtarget assignments)	1	cloned	lmo0193	16802239	-	hypothetical protein lmo0193 [Listeria m...	225	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FPP	22.7%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02422 (show subtarget assignments)	1	cloned	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP05488 (show subtarget assignments)	1	cloned	BA_4789	30259275		putative LPXTG-motif cell wall anchor do...	237	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K78	22.8%	Bacillus anthracis	Unknown function: General

IDP91020 (show subtarget assignments)	8	purified	y2842	22126718		hypothetical protein y2842 [Yersinia pes...	378	other biological interest / putative periplasmic iron-binding protein	Community Requests	2ETV	22.8%	Yersinia pestis

IDP02115 (show subtarget assignments)	1	purified	FTT0900	56708001		hypothetical protein FTT0900 [Francisell...	123	Drug Target	Community Requests	2GM2	22.8%	Francisella tularensis	Cell envelope	Other

IDP91730 (show subtarget assignments)	8	selected	NP_683513	22538811	CCL28	C-C motif chemokine 28 precursor [Homo s...	127	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2KUM	22.8%	Homo sapiens

IDP91307 (show subtarget assignments)	8	expressed	VP1663	28898437		putative YscY [Vibrio parahaemolyticus R...	114	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2FO7	22.8%	Vibrio parahaemolyticus

IDP02835 (show subtarget assignments)	1	expressed	FTT0631	56707756	hflX	protease, GTP-binding subunit [Francisel...	435	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2QTF	22.8%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01688 (show subtarget assignments)	0	work_stopped	Cj1313	15792636		GNAT family acetyltransferase [Campyloba...	157	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3EG7	22.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01176 (show subtarget assignments)	1	expressed	BA_2869	30257466		peptidase, putative	358	Drug Target Function	Phase 2: March 2008	3CE2	22.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02788 (show subtarget assignments)	1	expressed	CBU_0140	29540760	ftsA	cell division protein FtsA [Coxiella bur...	410	Conserved; Drug target functions	Phase 3: June 2008	1E4F	22.9%	Coxiella burnetii	Cellular processes	Cell division

IDP04242 (show subtarget assignments)	1	cloned	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02486 (show subtarget assignments)	1	purified	GBAA4209	47529502		Ppx/GppA phosphatase family protein [Bac...	512	Conserved; Drug target functions	Phase 3: June 2008	3HI0	23%	Bacillus anthracis	Central intermediary metabolism	Phosphorus compounds

IDP91636 (show subtarget assignments)	8	cloned	NP_217464	15610085		acyl-CoA synthetase [Mycobacterium tuber...	705	virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...	Community Requests	2V7B	23%	Mycobacterium tuberculosis

IDP02167 (show subtarget assignments)	1	expressed	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91432 (show subtarget assignments)	8	cloned	VV1_0487	27363951		prephenate dehydratase [Vibrio vulnificu...	392	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2QMX	23%	Vibrio vulnificus

IDP05382 (show subtarget assignments)	1	purified	BA_0925	30254668		putative lipoprotein [Bacillus anthracis...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2QPQ	23.1%	Bacillus anthracis	Cell envelope: Other

IDP05282 (show subtarget assignments)	1	soluble	CD0228	126697799	fliN	flagellar motor switch protein [Clostrid...	104	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1O6A	23.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02806 (show subtarget assignments)	1	cloned	Cj1133	15792458	waaC	lipopolysaccharide heptosyltransferase I...	342	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2GT1	23.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91316 (show subtarget assignments)	8	soluble	VV2_1515	27367862		toxin secretion ATP-binding protein [Vib...	717	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3G5U	23.1%	Vibrio vulnificus

IDP04674 (show subtarget assignments)	1	expressed	GBAA1956	47527252		sensor histidine kinase [Bacillus anthra...	351	putative drug target function;	Phase 4: April 2009	3A0R	23.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05271 (show subtarget assignments)	1	cloned	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02431 (show subtarget assignments)	1	crystallized	CBU_1770	29542327		ABC transporter, ATP-binding protein [Co...	432	Conserved; Drug target functions	Phase 3: June 2008	2YYZ	23.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01248 (show subtarget assignments)	1	soluble	BA_3554	30258085		penicillin-binding protein, putative	377	Drug Target Function	Phase 2: March 2008	3TG9	23.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04148 (show subtarget assignments)	1	expressed	YPO3508	115349133	basS	two-component system sensor protein [Yer...	355	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	23.1%	Yersinia pestis	Regulatory functions	Other

IDP05081 (show subtarget assignments)	1	cloned	lmo2027	16804066	-	putative cell surface protein, internali...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Y5Q	23.2%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP90285 (show subtarget assignments)	8	selected	TGME49_083850	211966798		peptidyl-prolyl isomerase, putative [Tox...	521	The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...	Community Requests	1KT0	23.2%	Toxoplasma gondii

IDP05173 (show subtarget assignments)	1	expressed	BA_2528	30257152		N-acetylmuramoyl-L-alanine amidase, fami...	410	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	23.2%	Bacillus anthracis	Cell envelope: Surface structures

IDP02721 (show subtarget assignments)	1	soluble	GBAA4007	47529300	coaBC	bifunctional phosphopantothenoylcysteine...	401	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02076 (show subtarget assignments)	1	soluble	STM3216	16766515		putative methyl-accepting chemotaxis pro...	521	Conserved; Drug target functions	Phase 3: June 2008	1QU7	23.2%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP02235 (show subtarget assignments)	1	purified	FTT1105c	56708184	msrA1	bifunctional methionine sulfoxide reduct...	284	Drug Target	Phase 3: June 2008	2GT3	23.2%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP91274 (show subtarget assignments)	8	selected	NT05BA4272	49181014		acetyl-CoA carboxylase, biotin carboxyl ...	164	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A6X	23.2%	Bacillus anthracis	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00550 (show subtarget assignments)	1	soluble	YPO3488	16123634	deaD	ATP-dependent RNA helicase DeaD	664	Virulence Associated Factor	Phase 2: March 2008	1HV8	23.3%	Yersinia pestis	Transcription	Other

IDP91400 (show subtarget assignments)	8	cloned	VV1_1002	27364436		ABC-type amino acid transport system, pe...	223	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DHW	23.3%	Vibrio vulnificus

IDP02626 (show subtarget assignments)	1	cloned	Cj1614	15792919	chuA	TonB-dependent heme receptor [Campylobac...	709	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3FHH	23.3%	Campylobacter jejuni	Regulatory functions	Other

IDP02009 (show subtarget assignments)	1	soluble	STM2925	16766231	nlpD	lipoprotein NlpD [Salmonella typhimurium...	377	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1QWY	23.3%	Salmonella enterica	Cell envelope	Other

IDP91952 (show subtarget assignments)	8	selected	SpneCM_010100008682	298255656		AmiA protein [Streptococcus pneumoniae s...	659	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B05	23.4%	Streptococcus pneumoniae

IDP02240 (show subtarget assignments)	1	cloned	FTT1572c	56708598	ompH	outer membrane protein OmpH [Francisella...	167	Drug Target	Phase 3: June 2008	1SG2	23.4%	Francisella tularensis	Cell envelopeMobile and extrachromosomal element functions	OtherProphage functions

IDP04335 (show subtarget assignments)	1	cloned	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP91407 (show subtarget assignments)	8	purified	VV1_0729	27364183		cAMP-binding proteins - catabolite gene ...	187	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3DN7	23.4%	Vibrio vulnificus

IDP05119 (show subtarget assignments)	1	soluble	CD2989	126700610		ABC transporter, substrate-binding prote...	319	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X7P	23.5%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP05164 (show subtarget assignments)	1	purified	BA_1735	30256021		putative ABC transporter, substrate-bind...	341	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2XD2	23.5%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05439 (show subtarget assignments)	1	soluble	lmo2499	16804537	-	hypothetical protein lmo2499 [Listeria m...	302	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1TWY	23.5%	Listeria monocytogenes	Transport and binding proteins: Anions

IDP04304 (show subtarget assignments)	1	cloned	CPF_2640	110798722		sensor histidine kinase [Clostridium per...	310	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	23.5%	Clostridium perfringens	Signal transduction	Two-component systems

IDP00161 (show subtarget assignments)	1	soluble	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP05541 (show subtarget assignments)	1	cloned	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02036 (show subtarget assignments)	1	cloned	GBAA1500	47526774		M23/37 family peptidase [Bacillus anthra...	204	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	3SLU	23.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05553 (show subtarget assignments)	1	cloned	lmo1136	16803176	-	hypothetical protein lmo1136 [Listeria m...	539	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.6%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP91017 (show subtarget assignments)	8	expressed	y2556	22126437	fcuA	ferrichrome receptor, TonB dependent [Ye...	776	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	3QLB	23.6%	Yersinia pestis

IDP05261 (show subtarget assignments)	1	cloned	CD2772	126700388	tuaG	putative teichuronic acid biosynthesis g...	212	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3BCV	23.6%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02477 (show subtarget assignments)	1	cloned	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP00190 (show subtarget assignments)	1	soluble	YPO0927	16121232	-	putative lipoprotein	250	Similar to Essential SALTY	Phase 1: October 2007	3C37	23.6%	Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP91641 (show subtarget assignments)	8	cloned	NP_216899	15609520		phenyloxazoline synthase MBTB (phenyloxa...	1414	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	2VSQ	23.6%	Mycobacterium tuberculosis

IDP90102 (show subtarget assignments)	8	expressed	MPXV_ZAI1979_005_002	68449079		TNF-alpha-receptor-like protein [Monkeyp...	348	similar to VACV-COP-C22L/B28R, MPXV-ZAI96-J2L/J2R	Community Requests	3ON9	23.6%	Monkeypox virus

IDP04014 (show subtarget assignments)	1	purified	YPO3173	115348814	thiI	thiamine biosynthesis protein [Yersinia ...	483	conserved gene; putative drug target function;	Phase 4: April 2009	2C5S	23.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01244 (show subtarget assignments)	1	cloned	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02695 (show subtarget assignments)	1	soluble	Cj0698	15792047	flgG	flagellar basal body rod protein FlgG [C...	263	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3A69	23.6%	Campylobacter jejuni	Unknown function	Enzymes of unknown specificity

IDP01729 (show subtarget assignments)	1	cloned	FTT0808	56707919	spoT	guanosine-3',5'-bis(diphosphate) 3'-pyro...	707	Conserved; Drug target functions	Phase 3: June 2008	1VJ7	23.6%	Francisella tularensis	Regulatory functionsAmino acid biosynthesis	OtherHistidine family

IDP02662 (show subtarget assignments)	1	purified	lmo1676	16803716	menF	menaquinone-specific isochorismate synth...	462	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3HWO	23.6%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP05607 (show subtarget assignments)	1	cloned	BA_4862	30259361		putative lipoprotein [Bacillus anthracis...	123	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2JQO	23.6%	Bacillus anthracis	Cell envelope: Other

IDP05315 (show subtarget assignments)	1	cloned	BAS0383	49183411	-	cell wall anchor domain-containing prote...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	23.6%	Bacillus anthracis	Cell envelope: Other

IDP00586 (show subtarget assignments)	1	purified	YPO3789	16123923	metR	lysR-family transcriptional regulatory p...	317	Virulence Associated Factor	Phase 2: March 2008	1AL3	23.7%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02796 (show subtarget assignments)	1	cloned	Cj1127c	15792452	wlaE	general glycosylation pathway protein [C...	365	Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...	Phase 3: June 2008	2JJM	23.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00207 (show subtarget assignments)	1	soluble	YPO1950	16122196	-	putative peptidase	405	Virulence	Phase 1: October 2007	1WN1	23.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01811 (show subtarget assignments)	1	expressed	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP00404 (show subtarget assignments)	1	soluble	YPCD1.48	16082736	virG	needle complex outer membrane lipoprotei...	131	Virulence Associated Factor	Phase 2: March 2008	2YJL	23.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP02252 (show subtarget assignments)	1	soluble	YPO1229	16121516	tsr2	putative methyl-accepting chemotaxis pro...	595	Conserved; Drug target functions	Phase 3: June 2008	1QU7	23.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP02269 (show subtarget assignments)	1	cloned	Cj0608	15791968		outer membrane efflux protein [Campyloba...	456	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	3PIK	23.7%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP05674 (show subtarget assignments)	1	soluble	lmo0859	16802900	-	hypothetical protein lmo0859 [Listeria m...	439	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QUF	23.7%	Listeria monocytogenes	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01502 (show subtarget assignments)	1	expressed	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP04115 (show subtarget assignments)	1	expressed	STM2352_1_235	16765679	hisM	histidine/lysine/arginine/ornithine tran...	235	Salmonella essential protein	Phase 4: April 2009	3DHW	23.8%	Salmonella enterica

IDP01470 (show subtarget assignments)	1	soluble	VC2608	15642603		ABC transporter, ATP-binding protein	664	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	23.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91493 (show subtarget assignments)	8	cloned	VP1690	28898464		putative type III secretion lipoprotein ...	248	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YJ7	23.8%	Vibrio parahaemolyticus

IDP91015 (show subtarget assignments)	8	selected	y2404	22126288	psn	pesticin/yersiniabactin outer membrane r...	673	TonB-dependent outer membrane receptor (yersiniabactin-binding)	Community Requests	1NQF	23.8%	Yersinia pestis

IDP00800 (show subtarget assignments)	1	soluble	SACOL1419	57286070		oligoendopeptidase F, putative	604	Drug Target Function	Phase 2: March 2008	2QR4	23.8%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05548 (show subtarget assignments)	1	cloned	lmo0409	16802454	-	hypothetical protein lmo0409 [Listeria m...	821	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1O6S	23.8%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP91364 (show subtarget assignments)	8	expressed	VV1_2716	27366006		Outer membrane protein [Vibrio vulnificu...	421	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1EK9	23.8%	Vibrio vulnificus

IDP00579 (show subtarget assignments)	1	cloned	YPO1122	16121422	tolR	colicin uptake protein TolR	142	Conserved Gene / Pathway	Phase 2: March 2008	2JWK	23.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP05291 (show subtarget assignments)	1	purified	CD1211	126698807		putative acetyltransferase [Clostridium ...	163	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	1YX0	23.9%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP91448 (show subtarget assignments)	8	expressed	VV1_0391	27363859		nucleotidyltransferase/DNA polymerase in...	418	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3QZ7	23.9%	Vibrio vulnificus

IDP05258 (show subtarget assignments)	1	cloned	CD2761	126700377		putative N-acetylmuramoyl-L-alanine amid...	301	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JWQ	23.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00791 (show subtarget assignments)	1	selected	SACOL1178	57284463		superantigen-like protein	238	Virulence Associated Factor	Phase 2: March 2008	1M4V	23.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00176 (show subtarget assignments)	1	cloned	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00780 (show subtarget assignments)	1	expressed	SACOL0694	57285664		tagH protein, teichoic acid ABC transpor...	264	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	23.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01734 (show subtarget assignments)	1	cloned	CBU_1094	29541668		efflux transporter, RND family, MFP subu...	380	Conserved; Drug target functions	Phase 3: June 2008	3FPP	23.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP00631 (show subtarget assignments)	1	purified	SACOL1537	57284636	scpB	segregation and condensation protein B	180	Conserved Gene / Pathway	Phase 2: March 2008	1T6S	23.9%	Staphylococcus aureus	Cellular processes	Cell division

IDP91872 (show subtarget assignments)	8	selected	ACM47285	222159812	vanYD	D,D-carboxypeptidase VanYD [Enterococcus...	363	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests	1ES4	24%	Enterococcus faecium

IDP02098 (show subtarget assignments)	1	purified	FTT0187	56707352	ftsA	cell division protein FtsA [Francisella ...	420	Conserved; Drug target functions	Phase 3: June 2008	1E4F	24%	Francisella tularensis	Cellular processes	Cell division

IDP01382 (show subtarget assignments)	1	cloned	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP02484 (show subtarget assignments)	1	expressed	GBAA3922	47529214		zinc protease [Bacillus anthracis str. '...	428	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HDI	24.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00217 (show subtarget assignments)	1	cloned	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP91960 (show subtarget assignments)	8	selected	SpneCM_010100008232	298255567		carbamate kinase [Streptococcus pneumoni...	423	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1B7B	24.1%	Streptococcus pneumoniae

IDP02481 (show subtarget assignments)	1	cloned	Cj1139c	15792464		putative galactosyltransferase [Campylob...	303	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3BCV	24.1%	Campylobacter jejuni	DNA metabolism	DNA replication, recombination, and repair

IDP91529 (show subtarget assignments)	8	soluble	VC_1312	9655801		alanine racemase, putative [Vibrio chole...	428	other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...	Community Requests	1BD0	24.1%	Vibrio cholerae

IDP90979 (show subtarget assignments)	8	cloned	y0636	22124550		hypothetical protein y0636 [Yersinia pes...	158	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	2Y75	24.1%	Yersinia pestis

IDP00010 (show subtarget assignments)	1	purified	BA_2144	30256791		uroporphyrin-III C-methyltransferase, pu...	474	Drug Target Homolog	Phase 1: October 2007	1PJQ	24.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00727 (show subtarget assignments)	1	cloned	SACOL2036	57284905		ABC transporter, ATP-binding protein	642	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	24.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP04408 (show subtarget assignments)	1	soluble	CPF_1426	110798602		iron(III) ABC transporter, iron(III)-bin...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GFV	24.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP05199
(show subtarget assignments)

1

cloned

CD1556

126699160

putative polysaccharide deacetylase [Clo...

277

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

22.7%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00773
(show subtarget assignments)

1

purified

SACOL0569

57285587

ATP:guanido phosphotransferase

335

Drug Target Function

Phase 2: March 2008

3L2D

22.7%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP05093
(show subtarget assignments)

1

cloned

lmo0193

16802239

-

hypothetical protein lmo0193 [Listeria m...

225

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FPP

22.7%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02422
(show subtarget assignments)

1

cloned

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP05488
(show subtarget assignments)

1

cloned

BA_4789

30259275

putative LPXTG-motif cell wall anchor do...

237

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K78

22.8%

Bacillus anthracis

Unknown function: General

IDP91020
(show subtarget assignments)

8

purified

y2842

22126718

hypothetical protein y2842 [Yersinia pes...

378

other biological interest / putative periplasmic iron-binding protein

Community Requests

2ETV

22.8%

Yersinia pestis

IDP02115
(show subtarget assignments)

1

purified

FTT0900

56708001

hypothetical protein FTT0900 [Francisell...

123

Drug Target

Community Requests

2GM2

22.8%

Francisella tularensis

Cell envelope

Other

IDP91730
(show subtarget assignments)

8

selected

NP_683513

22538811

CCL28

C-C motif chemokine 28 precursor [Homo s...

127

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2KUM

22.8%

Homo sapiens

IDP91307
(show subtarget assignments)

8

expressed

VP1663

28898437

putative YscY [Vibrio parahaemolyticus R...

114

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2FO7

22.8%

Vibrio parahaemolyticus

IDP02835
(show subtarget assignments)

1

expressed

FTT0631

56707756

hflX

protease, GTP-binding subunit [Francisel...

435

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2QTF

22.8%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01688
(show subtarget assignments)

0

work_stopped

Cj1313

15792636

GNAT family acetyltransferase [Campyloba...

157

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3EG7

22.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01176
(show subtarget assignments)

1

expressed

BA_2869

30257466

peptidase, putative

358

Drug Target Function

Phase 2: March 2008

3CE2

22.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02788
(show subtarget assignments)

1

expressed

CBU_0140

29540760

ftsA

cell division protein FtsA [Coxiella bur...

410

Conserved; Drug target functions

Phase 3: June 2008

1E4F

22.9%

Coxiella burnetii

Cellular processes

Cell division

IDP04242
(show subtarget assignments)

1

cloned

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02486
(show subtarget assignments)

1

purified

GBAA4209

47529502

Ppx/GppA phosphatase family protein [Bac...

512

Conserved; Drug target functions

Phase 3: June 2008

3HI0

23%

Bacillus anthracis

Central intermediary metabolism

Phosphorus compounds

IDP91636
(show subtarget assignments)

8

cloned

NP_217464

15610085

acyl-CoA synthetase [Mycobacterium tuber...

705

virulence/pathogenesis / Required for the synthesis of the phthiocerol dimycocerosates and related compou...

Community Requests

2V7B

23%

Mycobacterium tuberculosis

IDP02167
(show subtarget assignments)

1

expressed

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91432
(show subtarget assignments)

8

cloned

VV1_0487

27363951

prephenate dehydratase [Vibrio vulnificu...

392

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2QMX

23%

Vibrio vulnificus

IDP05382
(show subtarget assignments)

1

purified

BA_0925

30254668

putative lipoprotein [Bacillus anthracis...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2QPQ

23.1%

Bacillus anthracis

Cell envelope: Other

IDP05282
(show subtarget assignments)

1

soluble

CD0228

126697799

fliN

flagellar motor switch protein [Clostrid...

104

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1O6A

23.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02806
(show subtarget assignments)

1

cloned

Cj1133

15792458

waaC

lipopolysaccharide heptosyltransferase I...

342

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2GT1

23.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91316
(show subtarget assignments)

8

soluble

VV2_1515

27367862

toxin secretion ATP-binding protein [Vib...

717

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3G5U

23.1%

Vibrio vulnificus

IDP04674
(show subtarget assignments)

1

expressed

GBAA1956

47527252

sensor histidine kinase [Bacillus anthra...

351

putative drug target function;

Phase 4: April 2009

3A0R

23.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05271
(show subtarget assignments)

1

cloned

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02431
(show subtarget assignments)

1

crystallized

CBU_1770

29542327

ABC transporter, ATP-binding protein [Co...

432

Conserved; Drug target functions

Phase 3: June 2008

2YYZ

23.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01248
(show subtarget assignments)

1

soluble

BA_3554

30258085

penicillin-binding protein, putative

377

Drug Target Function

Phase 2: March 2008

3TG9

23.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04148
(show subtarget assignments)

1

expressed

YPO3508

115349133

basS

two-component system sensor protein [Yer...

355

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

23.1%

Yersinia pestis

Regulatory functions

Other

IDP05081
(show subtarget assignments)

1

cloned

lmo2027

16804066

-

putative cell surface protein, internali...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Y5Q

23.2%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP90285
(show subtarget assignments)

8

selected

TGME49_083850

211966798

peptidyl-prolyl isomerase, putative [Tox...

521

The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...

Community Requests

1KT0

23.2%

Toxoplasma gondii

IDP05173
(show subtarget assignments)

1

expressed

BA_2528

30257152

N-acetylmuramoyl-L-alanine amidase, fami...

410

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

23.2%

Bacillus anthracis

Cell envelope: Surface structures

IDP02721
(show subtarget assignments)

1

soluble

GBAA4007

47529300

coaBC

bifunctional phosphopantothenoylcysteine...

401

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02076
(show subtarget assignments)

1

soluble

STM3216

16766515

putative methyl-accepting chemotaxis pro...

521

Conserved; Drug target functions

Phase 3: June 2008

1QU7

23.2%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP02235
(show subtarget assignments)

1

purified

FTT1105c

56708184

msrA1

bifunctional methionine sulfoxide reduct...

284

Drug Target

Phase 3: June 2008

2GT3

23.2%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP91274
(show subtarget assignments)

8

selected

NT05BA4272

49181014

acetyl-CoA carboxylase, biotin carboxyl ...

164

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A6X

23.2%

Bacillus anthracis

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00550
(show subtarget assignments)

1

soluble

YPO3488

16123634

deaD

ATP-dependent RNA helicase DeaD

664

Virulence Associated Factor

Phase 2: March 2008

1HV8

23.3%

Yersinia pestis

Transcription

Other

IDP91400
(show subtarget assignments)

8

cloned

VV1_1002

27364436

ABC-type amino acid transport system, pe...

223

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DHW

23.3%

Vibrio vulnificus

IDP02626
(show subtarget assignments)

1

cloned

Cj1614

15792919

chuA

TonB-dependent heme receptor [Campylobac...

709

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3FHH

23.3%

Campylobacter jejuni

Regulatory functions

Other

IDP02009
(show subtarget assignments)

1

soluble

STM2925

16766231

nlpD

lipoprotein NlpD [Salmonella typhimurium...

377

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1QWY

23.3%

Salmonella enterica

Cell envelope

Other

IDP91952
(show subtarget assignments)

8

selected

SpneCM_010100008682

298255656

AmiA protein [Streptococcus pneumoniae s...

659

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B05

23.4%

Streptococcus pneumoniae

IDP02240
(show subtarget assignments)

1

cloned

FTT1572c

56708598

ompH

outer membrane protein OmpH [Francisella...

167

Drug Target

Phase 3: June 2008

1SG2

23.4%

Francisella tularensis

Cell envelopeMobile and extrachromosomal element functions

OtherProphage functions

IDP04335
(show subtarget assignments)

1

cloned

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP91407
(show subtarget assignments)

8

purified

VV1_0729

27364183

cAMP-binding proteins - catabolite gene ...

187

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3DN7

23.4%

Vibrio vulnificus

IDP05119
(show subtarget assignments)

1

soluble

CD2989

126700610

ABC transporter, substrate-binding prote...

319

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X7P

23.5%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP05164
(show subtarget assignments)

1

purified

BA_1735

30256021

putative ABC transporter, substrate-bind...

341

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2XD2

23.5%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05439
(show subtarget assignments)

1

soluble

lmo2499

16804537

-

hypothetical protein lmo2499 [Listeria m...

302

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1TWY

23.5%

Listeria monocytogenes

Transport and binding proteins: Anions

IDP04304
(show subtarget assignments)

1

cloned

CPF_2640

110798722

sensor histidine kinase [Clostridium per...

310

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

23.5%

Clostridium perfringens

Signal transduction

Two-component systems

IDP00161
(show subtarget assignments)

1

soluble

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05541
(show subtarget assignments)

1

cloned

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02036
(show subtarget assignments)

1

cloned

GBAA1500

47526774

M23/37 family peptidase [Bacillus anthra...

204

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

3SLU

23.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05553
(show subtarget assignments)

1

cloned

lmo1136

16803176

-

hypothetical protein lmo1136 [Listeria m...

539

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.6%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP91017
(show subtarget assignments)

8

expressed

y2556

22126437

fcuA

ferrichrome receptor, TonB dependent [Ye...

776

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

3QLB

23.6%

Yersinia pestis

IDP05261
(show subtarget assignments)

1

cloned

CD2772

126700388

tuaG

putative teichuronic acid biosynthesis g...

212

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3BCV

23.6%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02477
(show subtarget assignments)

1

cloned

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP00190
(show subtarget assignments)

1

soluble

YPO0927

16121232

-

putative lipoprotein

250

Similar to Essential SALTY

Phase 1: October 2007

3C37

23.6%

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP91641
(show subtarget assignments)

8

cloned

NP_216899

15609520

phenyloxazoline synthase MBTB (phenyloxa...

1414

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

2VSQ

23.6%

Mycobacterium tuberculosis

IDP90102
(show subtarget assignments)

8

expressed

MPXV_ZAI1979_005_002

68449079

TNF-alpha-receptor-like protein [Monkeyp...

348

Community Requests

3ON9

23.6%

Monkeypox virus

IDP04014
(show subtarget assignments)

1

purified

YPO3173

115348814

thiI

thiamine biosynthesis protein [Yersinia ...

483

conserved gene; putative drug target function;

Phase 4: April 2009

2C5S

23.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01244
(show subtarget assignments)

1

cloned

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02695
(show subtarget assignments)

1

soluble

Cj0698

15792047

flgG

flagellar basal body rod protein FlgG [C...

263

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3A69

23.6%

Campylobacter jejuni

Unknown function

Enzymes of unknown specificity

IDP01729
(show subtarget assignments)

1

cloned

FTT0808

56707919

spoT

guanosine-3',5'-bis(diphosphate) 3'-pyro...

707

Conserved; Drug target functions

Phase 3: June 2008

1VJ7

23.6%

Francisella tularensis

Regulatory functionsAmino acid biosynthesis

OtherHistidine family

IDP02662
(show subtarget assignments)

1

purified

lmo1676

16803716

menF

menaquinone-specific isochorismate synth...

462

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3HWO

23.6%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP05607
(show subtarget assignments)

1

cloned

BA_4862

30259361

putative lipoprotein [Bacillus anthracis...

123

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2JQO

23.6%

Bacillus anthracis

Cell envelope: Other

IDP05315
(show subtarget assignments)

1

cloned

BAS0383

49183411

-

cell wall anchor domain-containing prote...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

23.6%

Bacillus anthracis

Cell envelope: Other

IDP00586
(show subtarget assignments)

1

purified

YPO3789

16123923

metR

lysR-family transcriptional regulatory p...

317

Virulence Associated Factor

Phase 2: March 2008

1AL3

23.7%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02796
(show subtarget assignments)

1

cloned

Cj1127c

15792452

wlaE

general glycosylation pathway protein [C...

365

Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...

Phase 3: June 2008

2JJM

23.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00207
(show subtarget assignments)

1

soluble

YPO1950

16122196

-

putative peptidase

405

Virulence

Phase 1: October 2007

1WN1

23.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01811
(show subtarget assignments)

1

expressed

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP00404
(show subtarget assignments)

1

soluble

YPCD1.48

16082736

virG

needle complex outer membrane lipoprotei...

131

Virulence Associated Factor

Phase 2: March 2008

2YJL

23.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP02252
(show subtarget assignments)

1

soluble

YPO1229

16121516

tsr2

putative methyl-accepting chemotaxis pro...

595

Conserved; Drug target functions

Phase 3: June 2008

1QU7

23.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP02269
(show subtarget assignments)

1

cloned

Cj0608

15791968

outer membrane efflux protein [Campyloba...

456

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

3PIK

23.7%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP05674
(show subtarget assignments)

1

soluble

lmo0859

16802900

-

hypothetical protein lmo0859 [Listeria m...

439

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QUF

23.7%

Listeria monocytogenes

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP01502
(show subtarget assignments)

1

expressed

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP04115
(show subtarget assignments)

1

expressed

STM2352_1_235

16765679

hisM

histidine/lysine/arginine/ornithine tran...

235

Salmonella essential protein

Phase 4: April 2009

3DHW

23.8%

Salmonella enterica

IDP01470
(show subtarget assignments)

1

soluble

VC2608

15642603

ABC transporter, ATP-binding protein

664

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

23.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91493
(show subtarget assignments)

8

cloned

VP1690

28898464

putative type III secretion lipoprotein ...

248

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YJ7

23.8%

Vibrio parahaemolyticus

IDP91015
(show subtarget assignments)

8

selected

y2404

22126288

psn

pesticin/yersiniabactin outer membrane r...

673

TonB-dependent outer membrane receptor (yersiniabactin-binding)

Community Requests

1NQF

23.8%

Yersinia pestis

IDP00800
(show subtarget assignments)

1

soluble

SACOL1419

57286070

oligoendopeptidase F, putative

604

Drug Target Function

Phase 2: March 2008

2QR4

23.8%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05548
(show subtarget assignments)

1

cloned

lmo0409

16802454

-

hypothetical protein lmo0409 [Listeria m...

821

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1O6S

23.8%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP91364
(show subtarget assignments)

8

expressed

VV1_2716

27366006

Outer membrane protein [Vibrio vulnificu...

421

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1EK9

23.8%

Vibrio vulnificus

IDP00579
(show subtarget assignments)

1

cloned

YPO1122

16121422

tolR

colicin uptake protein TolR

142

Conserved Gene / Pathway

Phase 2: March 2008

2JWK

23.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP05291
(show subtarget assignments)

1

purified

CD1211

126698807

putative acetyltransferase [Clostridium ...

163

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

1YX0

23.9%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP91448
(show subtarget assignments)

8

expressed

VV1_0391

27363859

nucleotidyltransferase/DNA polymerase in...

418

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3QZ7

23.9%

Vibrio vulnificus

IDP05258
(show subtarget assignments)

1

cloned

CD2761

126700377

putative N-acetylmuramoyl-L-alanine amid...

301

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JWQ

23.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00791
(show subtarget assignments)

1

selected

SACOL1178

57284463

superantigen-like protein

238

Virulence Associated Factor

Phase 2: March 2008

1M4V

23.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00176
(show subtarget assignments)

1

cloned

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00780
(show subtarget assignments)

1

expressed

SACOL0694

57285664

tagH protein, teichoic acid ABC transpor...

264

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

23.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01734
(show subtarget assignments)

1

cloned

CBU_1094

29541668

efflux transporter, RND family, MFP subu...

380

Conserved; Drug target functions

Phase 3: June 2008

3FPP

23.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP00631
(show subtarget assignments)

1

purified

SACOL1537

57284636

scpB

segregation and condensation protein B

180

Conserved Gene / Pathway

Phase 2: March 2008

1T6S

23.9%

Staphylococcus aureus

Cellular processes

Cell division

IDP91872
(show subtarget assignments)

8

selected

ACM47285

222159812

vanYD

D,D-carboxypeptidase VanYD [Enterococcus...

363

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

1ES4

24%

Enterococcus faecium

IDP02098
(show subtarget assignments)

1

purified

FTT0187

56707352

ftsA

cell division protein FtsA [Francisella ...

420

Conserved; Drug target functions

Phase 3: June 2008

1E4F

24%

Francisella tularensis

Cellular processes

Cell division

IDP01382
(show subtarget assignments)

1

cloned

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP02484
(show subtarget assignments)

1

expressed

GBAA3922

47529214

zinc protease [Bacillus anthracis str. '...

428

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HDI

24.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00217
(show subtarget assignments)

1

cloned

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP91960
(show subtarget assignments)

8

selected

SpneCM_010100008232

298255567

carbamate kinase [Streptococcus pneumoni...

423

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1B7B

24.1%

Streptococcus pneumoniae

IDP02481
(show subtarget assignments)

1

cloned

Cj1139c

15792464

putative galactosyltransferase [Campylob...

303

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3BCV

24.1%

Campylobacter jejuni

DNA metabolism

DNA replication, recombination, and repair

IDP91529
(show subtarget assignments)

8

soluble

VC_1312

9655801

alanine racemase, putative [Vibrio chole...

428

other biological interest / The protein we are submitting is a broad spectrum amino acid racemase (Lam et al...

Community Requests

1BD0

24.1%

Vibrio cholerae

IDP90979
(show subtarget assignments)

8

cloned

y0636

22124550

hypothetical protein y0636 [Yersinia pes...

158

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

2Y75

24.1%

Yersinia pestis

IDP00010
(show subtarget assignments)

1

purified

BA_2144

30256791

uroporphyrin-III C-methyltransferase, pu...

474

Drug Target Homolog

Phase 1: October 2007

1PJQ

24.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00727
(show subtarget assignments)

1

cloned

SACOL2036

57284905

ABC transporter, ATP-binding protein

642

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

24.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP04408
(show subtarget assignments)

1

soluble

CPF_1426

110798602

iron(III) ABC transporter, iron(III)-bin...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GFV

24.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds