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Targets
Filter Targets:
Selection Phase:
No Filter
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM 10
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
Clostridium difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
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Keyword:
Type Keyword
Stage:
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cloned
crystallized
crystal_structure
diffraction
expressed
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
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CSGID ID
Priority
stage
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90225
(
show subtarget assignments
)
8
in_pdb
3K29
CT670
3329121
Hypothetical
168
Chlamydia type III secretion associated protein CT670
Community Requests
3K29
100%
Chlamydia trachomatis
IDP90224
(
show subtarget assignments
)
8
in_pdb
3I0U
CP0010
31983551
OspF
Shigella OspF effector
239
Shigella OspF effector
Community Requests
3I0U
90.8%
Shigella flexneri
IDP90253
(
show subtarget assignments
)
8
purified
SAR1776
49483939
pyk
pyruvate kinase [Staphylococcus aureus s...
585
(From requester) Potential drug target
Community Requests
3T05
100%
Staphylococcus aureus
IDP90248
(
show subtarget assignments
)
8
purified
BAS0467
49183495
acetylornithine deacetylase [Bacillus an...
426
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3PFO
27%
Bacillus anthracis
IDP90247
(
show subtarget assignments
)
8
soluble
YPO3928
115349537
argE
acetylornithine deacetylase [Yersinia pe...
389
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3PFO
26%
Yersinia pestis
IDP90246
(
show subtarget assignments
)
8
in_pdb
3T68
3T6M
VC2152
15642151
succinyl-diaminopimelate desuccinylase [...
377
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3T68
70%
Vibrio cholerae
IDP90250
(
show subtarget assignments
)
8
expressed
Z5515
15804553
argE
acetylornithine deacetylase [Escherichia...
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
26.9%
Escherichia coli
IDP90249
(
show subtarget assignments
)
8
soluble
VC2645
15642640
acetylornithine deacetylase [Vibrio chol...
378
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2F7V
26.8%
Vibrio cholerae
IDP90251
(
show subtarget assignments
)
8
expressed
SF4034
56480493
argE
acetylornithine deacetylase [Shigella fl...
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2F7V
25.1%
Shigella flexneri
IDP90802
(
show subtarget assignments
)
8
purified
YPO3769
16123905
3-octaprenyl-4-hydroxybenzoate decarboxy...
498
Predicted Essential
Community Requests
2IDB
88.2%
Yersinia pestis
IDP90267
(
show subtarget assignments
)
8
purified
TP_0326
3322602
Treponema pallidum subsp. pallidum str. ...
853
From requestor: The structural characterization of Tp0326 will be helpful in at ...
Community Requests
3EFC
11.6%
Treponema pallidum
IDP90254
(
show subtarget assignments
)
8
selected
AAK67494
21263110
ie1
IE1 protein [Human herpesvirus 6]
1078
(From requester) The IE1 protein of HHV-6, one of the first viral proteins synth...
Community Requests
Human herpesvirus
IDP90276
(
show subtarget assignments
)
8
cloned
TGME49_032600
211965793
patatin-like phospholipase domain-contai...
664
Signature-tagged mutagenesis (STM) has identified this patatin-like phospholipas...
Community Requests
Toxoplasma gondii
IDP90332
(
show subtarget assignments
)
8
cloned
CT_421.1
3522895
hypothetical protein [Chlamydia trachoma...
53
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90271
(
show subtarget assignments
)
8
in_pdb
3M5R
3M8A
ACP44186
227977167
NS1
nonstructural protein 1 [Influenza A vir...
219
swine flu virus
Community Requests
3F5T
79.9%
Influenza A
IDP90275
(
show subtarget assignments
)
8
selected
TGME49_030450
211965620
GMP synthase, putative [Toxoplasma gondi...
569
Guanosine monophosphate synthetase is essential for the synthesis of GMP in puri...
Community Requests
1GPM
51%
Toxoplasma gondii
IDP90272
(
show subtarget assignments
)
8
cloned
TGME49_111670
211962063
hypothetical protein TGME49_111670 [Toxo...
440
Unpublished data from signature-tagged mutagenesis (STM) has identified this sur...
Community Requests
Toxoplasma gondii
IDP90273
(
show subtarget assignments
)
8
cloned
TGME49_013900
211968791
regulator of chromosome condensation, pu...
1155
Signature-tagged mutagenesis (STM) has identified the regulator of chromosome co...
Community Requests
3MVD
11.1%
Toxoplasma gondii
IDP90278
(
show subtarget assignments
)
8
crystallized
TGME49_003450
211965291
hypothetical protein, conserved [Toxopla...
227
Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...
Community Requests
2PD0
41.9%
Toxoplasma gondii
IDP90280
(
show subtarget assignments
)
8
selected
TGME49_004420
211965378
oocyst wall protein COWP, putative [Toxo...
499
Unpublished data from a differentiation mutagenesis screen indicate that the ooc...
Community Requests
1N7D
19%
Toxoplasma gondii
IDP90284
(
show subtarget assignments
)
8
expressed
TGME49_070250
211963365
dense granule protein 1 / major antigenp...
190
GRA1 is secreted from dense granule as one of the few soluble proteins that can ...
Community Requests
Toxoplasma gondii
IDP90283
(
show subtarget assignments
)
8
cloned
TGME49_075440
211969603
GRA6
granule antigen protein GRA6 [Toxoplasma...
224
GRA6 is a secreted dense granule protein that generates protective immunity, e.g...
Community Requests
Toxoplasma gondii
IDP00183
(
show subtarget assignments
)
1
cloned
YPO0613
16120939
-
putative permease protein
293
Virulence
Phase 1: October 2007
2R6G
22.5%
Yersinia pestis
IDP90286
(
show subtarget assignments
)
8
in_pdb
3UKS
TGME49_035700
211966629
sedoheptulose-1,7 bisphosphatase, putati...
330
Unpublished data indicate that the Calvin cycle enzyme sedoheptulose-1,7-bisphos...
Community Requests
3UKS
100%
Toxoplasma gondii
IDP90288
(
show subtarget assignments
)
0
work_stopped
TGME49_093690
211967835
profilin family protein [Toxoplasma gond...
163
Parasite profilin is indispensable for gliding motility, host cell invasion, act...
Community Requests
3NEC
100%
Toxoplasma gondii
IDP90287
(
show subtarget assignments
)
8
purified
TGME49_021210
211967615
18 kDa cyclophilin [Toxoplasma gondii ME...
179
Parasite cyclophilin 18 (TgC18) is an agonist of chemokine receptor CCR5 on T c...
Community Requests
1AK4
53.6%
Toxoplasma gondii
IDP90291
(
show subtarget assignments
)
8
soluble
TGME49_081900
211969063
high mobility group (HMG) box domain-con...
880
The newly described histone lysine methyl-transferase KMTox targets histones H4 ...
Community Requests
Toxoplasma gondii
IDP90295
(
show subtarget assignments
)
8
cloned
TGME49_005290
211965425
dual-specificity phosphatase laforin, pu...
523
Human Lafora disease is one of five major progressive myoclonus epilepsies that ...
Community Requests
Toxoplasma gondii
IDP90292
(
show subtarget assignments
)
8
cloned
TGGT1_004130
221483205
histone acetyltransferase GCN5, putative...
1169
The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...
Community Requests
1Z4R
8.5%
Toxoplasma gondii
IDP90293
(
show subtarget assignments
)
8
in_pdb
3OTR
TGME49_068860
211963243
enolase 1 [Toxoplasma gondii ME49]
444
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
100%
Toxoplasma gondii
IDP90296
(
show subtarget assignments
)
8
soluble
TGME49_068850
211963242
enolase 2 [Toxoplasma gondii ME49]
475
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
68.8%
Toxoplasma gondii
IDP90712
(
show subtarget assignments
)
8
cloned
Cj1638
15792943
dnaG
DNA primase [Campylobacter jejuni subsp....
605
Predicted Essential
Community Requests
2AU3
18.3%
Campylobacter jejuni
IDP90711
(
show subtarget assignments
)
8
in_pdb
3LER
3M5V
Cj0806
15792144
dapA
dihydrodipicolinate synthase [Campylobac...
298
Predicted Essential
Community Requests
3M5V
100%
Campylobacter jejuni
IDP90710
(
show subtarget assignments
)
8
purified
Cj0451
15791815
rep
ribulose-phosphate 3-epimerase [Campylob...
215
Predicted Essential
Community Requests
1RPX
48.4%
Campylobacter jejuni
IDP90302
(
show subtarget assignments
)
0
work_stopped
BB_0420
2688313
sensory transduction histidine kinase, p...
1494
Mutational studies suggest that Hk1 is required for the survival of the Lyme dis...
Community Requests
3A0R
5.6%
Borrelia burgdorferi
IDP90314
(
show subtarget assignments
)
8
soluble
CT_733
3329191
hypothetical protein [Chlamydia trachoma...
448
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90300
(
show subtarget assignments
)
8
in_pdb
3QYQ
TGME49_118750
211967477
deoxyribose-phosphate aldolase, putative...
286
The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be s...
Community Requests
3QYQ
96.5%
Toxoplasma gondii
IDP90301
(
show subtarget assignments
)
8
selected
TGME49_025290
211963866
nucleoside-triphosphatase, putative [Tox...
642
The T. gondii nucleoside triphosphate hydrolases (NTPase) are ecto ATPases with ...
Community Requests
3AGR
38.6%
Toxoplasma gondii
IDP90331
(
show subtarget assignments
)
8
selected
CT_874
3329350
pmpI
Putative Outer Membrane Protein I [Chlam...
878
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90304
(
show subtarget assignments
)
8
soluble
CT_671
3329122
hypothetical protein [Chlamydia trachoma...
283
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90306
(
show subtarget assignments
)
8
cloned
CT_694
3329148
hypothetical protein [Chlamydia trachoma...
323
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90305
(
show subtarget assignments
)
8
cloned
CT_681
3329133
ompA
Major Outer Membrane Protein [Chlamydia ...
393
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90717
(
show subtarget assignments
)
8
in_pdb
3Q3V
Cj1402c
15792720
pgk
phosphoglycerate kinase [Campylobacter j...
400
Predicted Essential
Community Requests
3Q3V
100%
Campylobacter jejuni
IDP90310
(
show subtarget assignments
)
8
expressed
CT_716
3329172
hypothetical protein [Chlamydia trachoma...
121
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90309
(
show subtarget assignments
)
8
cloned
CT_702
3329157
hypothetical protein [Chlamydia trachoma...
175
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90313
(
show subtarget assignments
)
8
cloned
CT_713
3329169
ompB
Outer Membrane Protein Analog [Chlamydia...
340
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90311
(
show subtarget assignments
)
8
cloned
CT_734
3329192
hypothetical protein [Chlamydia trachoma...
221
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90720
(
show subtarget assignments
)
8
purified
Cj0348
15791716
trpB
tryptophan synthase subunit beta [Campyl...
392
Predicted Essential
Community Requests
1V8Z
51.5%
Campylobacter jejuni
IDP90312
(
show subtarget assignments
)
8
expressed
CT_712
3329168
hypothetical protein [Chlamydia trachoma...
390
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90718
(
show subtarget assignments
)
8
in_pdb
3N4J
3N4K
YPO0071
16120422
putative methyltransferase [Yersinia pes...
162
Predicted Essential
Community Requests
3N4J
100%
Yersinia pestis
IDP90316
(
show subtarget assignments
)
8
cloned
CT_743
3329202
hctA
Histone-Like Developmental Protein [Chla...
125
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90725
(
show subtarget assignments
)
8
soluble
VC0295
15640323
acetyl-CoA carboxylase biotin carboxylas...
447
Predicted Essential
Community Requests
1BNC
85.5%
Vibrio cholerae
IDP90315
(
show subtarget assignments
)
8
cloned
CT_744
3329204
CHLTR possible phosphoprotein [Chlamydia...
821
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90921
(
show subtarget assignments
)
8
purified
YPO2984
16123165
gltX
glutamyl-tRNA synthetase [Yersinia pesti...
471
Predicted Essential
Community Requests
2CFO
38.4%
Yersinia pestis
IDP90319
(
show subtarget assignments
)
8
cloned
CT_753
3329214
hypothetical protein [Chlamydia trachoma...
74
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90320
(
show subtarget assignments
)
8
cloned
CT_779
3329243
hypothetical protein [Chlamydia trachoma...
229
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90318
(
show subtarget assignments
)
8
purified
CT_718
3329174
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90317
(
show subtarget assignments
)
8
cloned
CT_724
3329181
hypothetical protein [Chlamydia trachoma...
174
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90322
(
show subtarget assignments
)
8
expressed
CT_809
3329276
hypothetical protein [Chlamydia trachoma...
103
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90321
(
show subtarget assignments
)
8
purified
CT_795
3329261
hypothetical protein [Chlamydia trachoma...
163
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90323
(
show subtarget assignments
)
8
cloned
CT082
15604801
hypothetical protein CT082 [Chlamydia tr...
560
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90324
(
show subtarget assignments
)
8
expressed
CT088
15604807
sycE
secretion chaperone [Chlamydia trachomat...
146
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90328
(
show subtarget assignments
)
8
cloned
CT_413
3328841
pmpB
Putative outer membrane protein B [Chlam...
1751
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90723
(
show subtarget assignments
)
8
purified
Cj0821
15792159
glmU
UDP-N-acetylglucosamine pyrophosphorylas...
429
Predicted Essential
Community Requests
1HM0
40.1%
Campylobacter jejuni
IDP90329
(
show subtarget assignments
)
8
cloned
CT_548
3328987
hypothetical protein [Chlamydia trachoma...
194
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90327
(
show subtarget assignments
)
8
cloned
CT_590
3329033
hypothetical protein [Chlamydia trachoma...
954
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00003
(
show subtarget assignments
)
1
expressed
GBAA_pXO1_0158
47566470
gerXC
spore germination protein xc, (pxo1-112)...
317
Drug Target Homolog
Phase 1: October 2007
Bacillus anthracis
IDP90337
(
show subtarget assignments
)
8
expressed
CT_623
6578109
CHLPN 76kDa Homolog [Chlamydia trachomat...
432
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90359
(
show subtarget assignments
)
8
cloned
CT794.1
15605528
hypothetical protein CT794.1 [Chlamydia ...
95
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00846
(
show subtarget assignments
)
1
cloned
SACOL1177
57284462
hypothetical protein SACOL1177
43
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP00843
(
show subtarget assignments
)
1
cloned
SACOL1859
57284780
hypothetical protein SACOL1859
1016
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP00810
(
show subtarget assignments
)
1
cloned
SACOL1870
57284791
hypothetical protein SACOL1870
188
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP00616
(
show subtarget assignments
)
1
cloned
SACOL1586
57286108
hypothetical protein SACOL1586
94
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP00600
(
show subtarget assignments
)
1
cloned
SACOL0532
57285557
hypothetical protein SACOL0532
51
Drug Target Function
Phase 2: March 2008
Staphylococcus aureus
0
0
IDP00586
(
show subtarget assignments
)
1
purified
YPO3789
16123923
metR
lysR-family transcriptional regulatory p...
317
Virulence Associated Factor
Phase 2: March 2008
1AL3
23.7%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP00585
(
show subtarget assignments
)
1
expressed
YPO0116
16120461
metL
bifunctional aspartate kinase II/homoser...
811
Virulence Associated Factor
Phase 2: March 2008
1EBF
15.5%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP00584
(
show subtarget assignments
)
1
soluble
YPO0117
16120462
metF
5,10-methylenetetrahydrofolate reductase...
294
Virulence Associated Factor
Phase 2: March 2008
1ZP3
86.4%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP02783
(
show subtarget assignments
)
1
expressed
FTT0425c
56707572
asd
aspartate-semialdehyde dehydrogenase [Fr...
364
Conserved; Drug target functions
Phase 3: June 2008
1NWC
50%
Francisella tularensis
Amino acid biosynthesis
Aspartate family
IDP01913
(
show subtarget assignments
)
1
cloned
GBAA1426
47526698
hisD
histidinol dehydrogenase [Bacillus anthr...
429
Conserved; Drug target functions
Phase 3: June 2008
1K75
39.2%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
IDP00574
(
show subtarget assignments
)
1
cloned
YPO0531
16120860
leuC
isopropylmalate isomerase large subunit ...
476
Virulence Associated Factor
Phase 2: March 2008
1ACO
25%
Yersinia pestis
Amino acid biosynthesis
Pyruvate family
IDP00571
(
show subtarget assignments
)
1
in_pdb
3GOS
YPO1041
16121341
dapD
2,3,4,5-tetrahydropyridine-2-carboxylate...
274
Virulence Associated Factor
Phase 2: March 2008
3GOS
100%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP02764
(
show subtarget assignments
)
1
expressed
CBU_0525
29541128
serC
phosphoserine aminotransferase [Coxiella...
360
Conserved; Drug target functions
Phase 3: June 2008
3QBO
53.6%
Coxiella burnetii
Amino acid biosynthesis
Serine family
IDP01915
(
show subtarget assignments
)
1
cloned
GBAA1421
47777930
leuB
3-isopropylmalate dehydrogenase [Bacillu...
354
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3U1H
60.3%
Bacillus anthracis
Amino acid biosynthesis
Pyruvate family
IDP00945
(
show subtarget assignments
)
0
work_stopped
STM0977
16764337
serC
phosphoserine aminotransferase
362
Conserved Gene / Pathway
Phase 2: March 2008
3QM2
100%
Salmonella enterica
Amino acid biosynthesis
Serine family
IDP00554
(
show subtarget assignments
)
1
purified
YPO1549
16121822
hisG
ATP phosphoribosyltransferase
299
Virulence Associated Factor
Phase 2: March 2008
1H3D
88%
Yersinia pestis
Amino acid biosynthesis
Histidine family
IDP02736
(
show subtarget assignments
)
1
cloned
GBAA4352
47778283
argD
acetylornithine aminotransferase [Bacill...
386
Conserved; Essential; Drug target functions
Phase 3: June 2008
2E54
44%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP01058
(
show subtarget assignments
)
1
purified
STM3486
16766774
aroB
3-dehydroquinate synthase
362
Conserved Gene / Pathway
Phase 2: March 2008
3OKF
62.4%
Salmonella enterica
Amino acid biosynthesis
Aromatic amino acid family
IDP01731
(
show subtarget assignments
)
1
expressed
CBU_1222
29541792
dapA
dihydrodipicolinate synthase [Coxiella b...
289
Conserved; Drug target functions
Phase 3: June 2008
3QZE
55.2%
Coxiella burnetii
Amino acid biosynthesis
Aspartate family
IDP00539
(
show subtarget assignments
)
1
purified
YPO2751
16122955
aroC
chorismate synthase
361
Conserved Gene / Pathway
Phase 2: March 2008
1R52
45%
Yersinia pestis
Amino acid biosynthesis
Aromatic amino acid family
IDP00538
(
show subtarget assignments
)
1
in_pdb
3GVD
YPO0070
16120421
cysE
serine acetyltransferase
273
Drug Target Function
Phase 2: March 2008
3GVD
100%
Yersinia pestis
Amino acid biosynthesis
Serine family
IDP00537
(
show subtarget assignments
)
1
purified
YPO3924
16124055
argH
argininosuccinate lyase
457
Conserved Gene / Pathway
Phase 2: March 2008
1TJ7
88.8%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP02676
(
show subtarget assignments
)
1
crystallized
GBAA1539
47526813
hisC-1
histidinol-phosphate aminotransferase [B...
370
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3FFH
46.2%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
IDP01917
(
show subtarget assignments
)
1
soluble
GBAA1429
47526701
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosy...
239
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1VZW
36.5%
Bacillus anthracis
Amino acid biosynthesis
Histidine family
IDP00946
(
show subtarget assignments
)
1
expressed
STM0978
16764338
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
427
Conserved Gene / Pathway
Phase 2: March 2008
1G6S
89.5%
Salmonella enterica
Amino acid biosynthesis
Aromatic amino acid family
IDP02718
(
show subtarget assignments
)
1
cloned
GBAA3833
47529118
glnA
glutamine synthetase, type I [Bacillus a...
444
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1LGR
44.6%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP02667
(
show subtarget assignments
)
1
cloned
lmo0565
16802608
hisH
imidazole glycerol phosphate synthase su...
208
Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...
Phase 3: June 2008
1OX4
33.5%
Listeria monocytogenes
Amino acid biosynthesis
Histidine family
IDP02669
(
show subtarget assignments
)
1
purified
GBAA1568
50196927
aspB
aspartate aminotransferase [Bacillus ant...
395
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1J32
45.8%
Bacillus anthracis
Amino acid biosynthesis
Aspartate family
IDP00519
(
show subtarget assignments
)
1
cloned
YPO3446
16123594
argI
ornithine carbamoyltransferase subunit I...
335
Conserved Gene / Pathway
Phase 2: March 2008
1AKM
79.1%
Yersinia pestis
Amino acid biosynthesis
Glutamate family
IDP02652
(
show subtarget assignments
)
1
expressed
GBAA1422
47526694
leuC
isopropylmalate isomerase large subunit ...
464
Conserved; Drug target functions
Phase 3: June 2008
2B3X
22%
Bacillus anthracis
Amino acid biosynthesis
Pyruvate family
IDP02636
(
show subtarget assignments
)
1
expressed
YPO3722
16123860
metH
B12-dependent methionine synthase [Yersi...
1231
CD; Drug target functions
Phase 3: June 2008
1K7Y
40.1%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
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