Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01349 (show subtarget assignments)	1	purified	VCA0253	15601021		antibiotic acetyltransferase	232	Drug Target Function	Phase 2: March 2008	3EEV	37.1%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01510 (show subtarget assignments)	1	purified	VC0731	15640750		antioxidant, AhpC/Tsa family	207	Conserved Gene / Pathway	Phase 2: March 2008	1ZOF	55.1%	Vibrio cholerae	Cellular processes	Detoxification

IDP01024 (show subtarget assignments)	1	purified	STM1172	16764528	flgM	anti-sigma28 factor FlgM	97	Conserved Gene / Pathway	Phase 2: March 2008			Salmonella enterica	Cell envelope	Surface structures

IDP04053 (show subtarget assignments)	1	cloned	CPF_2307	110801393	spoIIAA	anti-sigma F factor antagonist [Clostrid...	111	conserved gene; putative drug target function;	Phase 4: April 2009	1TH8	45%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP91189 (show subtarget assignments)	1	in_pdb 3R80 3R81	AAW59417	57918602	aph(2'')-Id	APH(2'')-Id [Enterococcus faecium]	301	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LZH	100%	Enterococcus faecium

IDP92066 (show subtarget assignments)	8	selected	ABO93620	144228223	GAPDH2	apicoplast glyceraldehyde-3-phosphate de...	995	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP91091 (show subtarget assignments)	8	cloned	APL_0387	126096663	kpsF	arabinose-5-phosphate isomerase [Actinob...	311	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	27%	Actinobacillus pleuropneumoniae

IDP00526 (show subtarget assignments)	1	purified	YPO1351	16121631	artI	arginine-binding periplasmic protein 1 p...	243	Conserved Gene / Pathway	Phase 2: March 2008	2Y7I	52.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP91383 (show subtarget assignments)	8	soluble	VV1_1467	27364851		arginine deiminase [Vibrio vulnificus CM...	406	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1RXX	45.3%	Vibrio vulnificus

IDP90289 (show subtarget assignments)	8	purified	TGME49_094270	211967870		arginine methyltransferase protein, puta...	660	Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...	Community Requests	2Y1W	24.5%	Toxoplasma gondii

IDP90290 (show subtarget assignments)	8	purified	TGME49_019520	211968370		arginine N-methyltransferase 1 [Toxoplas...	392	The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...	Community Requests	1OR8	44.9%	Toxoplasma gondii

IDP91417 (show subtarget assignments)	8	in_pdb 3V4G	VV1_0674	27364131		arginine repressor [Vibrio vulnificus CM...	156	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3V4G	100%	Vibrio vulnificus

IDP00944 (show subtarget assignments)	1	crystallized	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01901 (show subtarget assignments)	1	purified	STM0890	16764251	artI	arginine transport system [Salmonella ty...	243	Conserved; Drug target functions	Phase 3: June 2008	2Y7I	51.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00537 (show subtarget assignments)	1	purified	YPO3924	16124055	argH	argininosuccinate lyase	457	Conserved Gene / Pathway	Phase 2: March 2008	1TJ7	88.8%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP02396 (show subtarget assignments)	1	purified	GBAA3604	47528890	argH-1	argininosuccinate lyase [Bacillus anthra...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E9F	27.5%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP04429 (show subtarget assignments)	1	purified	GBAA4879	47530172	argH-2	argininosuccinate lyase [Bacillus anthra...	462	conserved gene; putative drug target function;	Phase 4: April 2009	2E9F	48.3%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP90621 (show subtarget assignments)	8	soluble	Cj0931c	15792260	argH	argininosuccinate lyase [Campylobacter j...	460	Predicted Essential	Community Requests	1AUW	44.8%	Campylobacter jejuni

IDP02815 (show subtarget assignments)	1	soluble	GBAA4880	47530173	argG	argininosuccinate synthase [Bacillus ant...	401	Conserved; Drug target functions	Phase 3: June 2008	1VL2	46.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP90768 (show subtarget assignments)	8	purified	Cj0665c	15792020	argG	argininosuccinate synthase [Campylobacte...	406	Predicted Essential	Community Requests	1J1Z	57.9%	Campylobacter jejuni

IDP05453 (show subtarget assignments)	1	purified	BAS5213	49188199	-	arginyl-tRNA synthetase [Bacillus anthra...	556	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.8%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05141 (show subtarget assignments)	1	cloned	BAS2021	49185032	argS	arginyl-tRNA synthetase [Bacillus anthra...	562	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1BS2	36.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP92024 (show subtarget assignments)	8	selected	TGME49_010840	237843883		arginyl-tRNA synthetase, putative [Toxop...	607	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP05255 (show subtarget assignments)	1	purified	SACOL0663	57650073	argS	arginyl-tRNA synthetase [Staphylococcus ...	553	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90894 (show subtarget assignments)	8	expressed	YPO2046	16122285	argS	arginyl-tRNA synthetase [Yersinia pestis...	576	Predicted Essential	Community Requests	1BS2	31.1%	Yersinia pestis

IDP04704 (show subtarget assignments)	1	cloned	YPO0322	115346138	tyrB	aromatic-amino-acid aminotransferase [Ye...	397	conserved gene; putative drug target function;	Phase 4: April 2009	3TAT	75.6%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01300 (show subtarget assignments)	1	in_pdb 3F0I	VC2165	15642164		arsenate reductase	116	Conserved Gene / Pathway	Phase 2: March 2008	3F0I	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP04016 (show subtarget assignments)	1	purified	CPF_0834	110798754	arsC	arsenate reductase ArsC [Clostridium per...	132	conserved gene; putative drug target function;	Phase 4: April 2009	2L17	40.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP01783 (show subtarget assignments)	1	expressed	FTT0824	56707935	arsC1	arsenate reductase [Francisella tularens...	117	Drug Target	Phase 3: June 2008	3GKX	25.6%	Francisella tularensis	Unknown function	General

IDP00841 (show subtarget assignments)	1	purified	SACOL0876	57284336		arsenate reductase, putative	118	Conserved Gene / Pathway	Phase 2: March 2008	3FZ4	41.5%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00724 (show subtarget assignments)	1	purified	SACOL1822	57286255	arsR	arsenical resistance operon repressor	104	Conserved Gene / Pathway	Phase 2: March 2008	1R1T	31.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP02193 (show subtarget assignments)	1	purified	FTT0868c	56707972		arsenical restistance operon repressor [...	121	Drug Target	Phase 3: June 2008	3JTH	22.3%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP91336 (show subtarget assignments)	8	expressed	VV2_0152	27366608		arylsulfatase regulator [Vibrio vulnific...	434	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP04523 (show subtarget assignments)	1	cloned	STM0884_1_447	16764245	ulaA	ascorbate-specific PTS system enzyme IIC...	447	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP01728 (show subtarget assignments)	1	expressed	CBU_0840	29541434	asnB-2	asparagine synthetase B, glutamine-hydro...	637	Conserved; Drug target functions	Phase 3: June 2008	1Q15	13%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01984 (show subtarget assignments)	1	expressed	CBU_0831	29541425	asnB-1	asparagine synthetase B, glutamine-hydro...	632	Conserved; Drug target functions	Phase 3: June 2008	1CT9	18.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04501 (show subtarget assignments)	1	cloned	VC0991	9655452		asparagine synthetase B, glutamine-hydro...	554	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CT9	75.3%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP02245 (show subtarget assignments)	1	cloned	GBAA1751	47527043	asnO-2	asparagine synthetase, glutamine-hydroly...	607	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CT9	25.9%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP05569 (show subtarget assignments)	1	soluble	BAS4454	49187449	-	asparaginyl-tRNA synthetase [Bacillus an...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	35.9%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05239 (show subtarget assignments)	1	cloned	lmo1896	16803935	ansB	asparaginyl-tRNA synthetase [Listeria mo...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.3%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05209 (show subtarget assignments)	1	purified	SACOL1494	57650409	asnC	asparaginyl-tRNA synthetase [Staphylococ...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.8%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90728 (show subtarget assignments)	8	cloned	YPO1412	16121692	asnC	asparaginyl-tRNA synthetase [Yersinia pe...	466	Predicted Essential	Community Requests	1X54	34.3%	Yersinia pestis

IDP04342 (show subtarget assignments)	1	cloned	GBAA1564	47526837	panD	aspartate alpha-decarboxylase [Bacillus ...	127	conserved gene; putative drug target function;	Phase 4: April 2009	2C45	52.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90506 (show subtarget assignments)	8	in_pdb 3PLX	Cj0296c	15791664	panD	aspartate alpha-decarboxylase [Campyloba...	126	Predicted Essential	Community Requests	3PLX	80.2%	Campylobacter jejuni

IDP02730 (show subtarget assignments)	1	in_pdb 3OUG	FTT1391	56708440	panD	aspartate alpha-decarboxylase [Francisel...	111	Drug Target	Phase 3: June 2008	3OUG	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90634 (show subtarget assignments)	8	purified	YPO3403	16123552	panD	aspartate alpha-decarboxylase [Yersinia ...	126	Predicted Essential	Community Requests	1PPY	78.6%	Yersinia pestis

IDP02669 (show subtarget assignments)	1	purified	GBAA1568	50196927	aspB	aspartate aminotransferase [Bacillus ant...	395	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J32	45.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02483 (show subtarget assignments)	1	cloned	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04167 (show subtarget assignments)	1	cloned	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP02640 (show subtarget assignments)	1	purified	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02192 (show subtarget assignments)	1	soluble	YPO0348	16120683	aspA	aspartate ammonia-lyase [Yersinia pestis...	478	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1JSW	89.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP90587 (show subtarget assignments)	8	in_pdb 3LXM	YPO3588	16123730	pyrB	aspartate carbamoyltransferase catalytic...	311	Predicted Essential	Community Requests	3LXM	100%	Yersinia pestis

IDP00670 (show subtarget assignments)	1	soluble	SACOL1212	57285955	pyrB	aspartate carbamoyltransferase catalytic...	293	Drug Target Function	Phase 2: March 2008	2AT2	55.6%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02775 (show subtarget assignments)	1	purified	GBAA4028	47529321	pyrB	aspartate carbamoyltransferase catalytic...	304	Conserved; Drug target functions	Phase 3: June 2008	3R7D	61.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90752 (show subtarget assignments)	8	soluble	Cj1098	15792423	pyrB	aspartate carbamoyltransferase catalytic...	295	Predicted Essential	Community Requests	2AT2	38.5%	Campylobacter jejuni

IDP91385 (show subtarget assignments)	8	soluble	VV1_1465	27364849	pyrB	aspartate carbamoyltransferase catalytic...	309	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2BE7	76.4%	Vibrio vulnificus

IDP04175 (show subtarget assignments)	1	purified	VC2511	9657094		aspartate carbamoyltransferase, regulato...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1D09	63.2%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04411 (show subtarget assignments)	1	soluble	YPO3589	218930599	pyrI	aspartate carbamoyltransferase regulator...	154	conserved gene; putative drug target function;	Phase 4: April 2009	1D09	77.3%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP92107 (show subtarget assignments)	8	selected	TGME49_091640	237838437		aspartate carbamoyltransferase [Toxoplas...	423	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP90746 (show subtarget assignments)	8	purified	Cj0582	15791942	lysC	aspartate kinase [Campylobacter jejuni s...	400	Predicted Essential	Community Requests	3AB4	48.9%	Campylobacter jejuni

IDP02060 (show subtarget assignments)	1	expressed	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01080 (show subtarget assignments)	0	work_stopped	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP90223 (show subtarget assignments)	1	expressed	SA1226	15926974	Asd	Aspartate semialdehyde dehydrogenase Asd...	329	This enzyme participates in glycine, serine and threonine metabolism and lysine ...	January 2009	2YV3	43.4%	Staphylococcus aureus

IDP02467 (show subtarget assignments)	1	soluble	GBAA3937	47529228	asd-2	aspartate-semialdehyde dehydrogenase [Ba...	348	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GYY	60.6%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04599 (show subtarget assignments)	1	cloned	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP90732 (show subtarget assignments)	8	soluble	Cj1023c	15792350	asd	aspartate-semialdehyde dehydrogenase [Ca...	343	Predicted Essential	Community Requests	2QZ9	45.8%	Campylobacter jejuni

IDP02042 (show subtarget assignments)	1	cloned	CBU_0875	29541467	asd	aspartate-semialdehyde dehydrogenase [Co...	340	Conserved; Drug target functions	Phase 3: June 2008	2QZ9	61.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02783 (show subtarget assignments)	1	expressed	FTT0425c	56707572	asd	aspartate-semialdehyde dehydrogenase [Fr...	364	Conserved; Drug target functions	Phase 3: June 2008	1NWC	50%	Francisella tularensis	Amino acid biosynthesis	Aspartate family

IDP90899 (show subtarget assignments)	8	soluble	YPO3949	16124077	asd	aspartate-semialdehyde dehydrogenase [Ye...	367	Predicted Essential	Community Requests	1BRM	83.4%	Yersinia pestis

IDP04155 (show subtarget assignments)	1	cloned	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP92103 (show subtarget assignments)	8	selected	TGME49_097970	237843837		aspartyl aminopeptidase, putative [Toxop...	506	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP90744 (show subtarget assignments)	8	expressed	Cj1059c	15792386	gatA	aspartyl/glutamyl-tRNA amidotransferase ...	453	Predicted Essential	Community Requests	3H0L	47.9%	Campylobacter jejuni

IDP90774 (show subtarget assignments)	8	purified	Cj1197c	15792521	gatB	aspartyl/glutamyl-tRNA amidotransferase ...	472	Predicted Essential	Community Requests	3H0L	49.2%	Campylobacter jejuni

IDP05333 (show subtarget assignments)	1	cloned	BAS2031	49185042	-	aspartyl-tRNA synthetase [Bacillus anthr...	432	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1N9W	49.5%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP04615 (show subtarget assignments)	1	cloned	BAS4297	49187293		aspartyl-tRNA synthetase [Bacillus anthr...	591	Proposed to be essential proteins	Phase 4: April 2009	1EQR	52.7%	Bacillus anthracis

IDP90630 (show subtarget assignments)	8	soluble	Cj0640c	15792000	aspS	aspartyl-tRNA synthetase [Campylobacter ...	583	Predicted Essential	Community Requests	1C0A	51.8%	Campylobacter jejuni

IDP05234 (show subtarget assignments)	1	cloned	lmo1519	16803559	aspS	aspartyl-tRNA synthetase [Listeria monoc...	591	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1EQR	52.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05303 (show subtarget assignments)	1	cloned	SACOL1685	57650511	aspS	aspartyl-tRNA synthetase [Staphylococcus...	588	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1C0A	54.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90878 (show subtarget assignments)	8	purified	VC1166	15641179	aspS	aspartyl-tRNA synthetase [Vibrio cholera...	591	Predicted Essential	Community Requests	1C0A	74.8%	Vibrio cholerae

IDP90838 (show subtarget assignments)	8	cloned	YPO2053	16122292	aspS	aspartyl-tRNA synthetase [Yersinia pesti...	598	Predicted Essential	Community Requests	1EQR	80.8%	Yersinia pestis

IDP01890 (show subtarget assignments)	1	cloned	Cj0063c	15791455		ATPase, ParA family [Campylobacter jejun...	288	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1HYQ	25.7%	Campylobacter jejuni	Cell envelope	Other

IDP91005 (show subtarget assignments)	8	soluble	y1936	22125828		ATP-binding component of a transport sys...	257	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	2ZU0	80.9%	Yersinia pestis

IDP04110 (show subtarget assignments)	1	expressed	YPO2440	218929529	yfeB	ATP-binding transport protein [Yersinia ...	296	virulence factor; conserved gene;	Phase 4: April 2009	3GFO	26.4%	Yersinia pestis	Unknown function	General

IDP01335 (show subtarget assignments)	1	soluble	VC1144	15641157	clpA	ATP-dependent Clp protease ATP-binding s...	756	Drug Target Function	Phase 2: March 2008	1KSF	77.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00663 (show subtarget assignments)	1	purified	SACOL0979	57285852	clpB	ATP-dependent Clp protease, ATP-binding ...	869	Drug Target Function	Phase 2: March 2008	1QVR	54.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02143 (show subtarget assignments)	1	expressed	CBU_0739	29541339	clpX	ATP-dependent Clp protease, ATP-binding ...	422	Conserved; Drug target functions	Phase 3: June 2008	3HTE	59.5%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01433 (show subtarget assignments)	1	soluble	VC1922	15641924	clpP	ATP-dependent Clp protease proteolytic s...	200	Drug Target Function	Phase 2: March 2008	1TYF	76%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01105 (show subtarget assignments)	1	soluble	BA_2788	67460529		ATP-dependent Clp protease proteolytic s...	193	Drug Target Function	Phase 2: March 2008	3TT7	67.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01711 (show subtarget assignments)	1	expressed	GBAA5380	47530690	clpP	ATP-dependent Clp protease proteolytic s...	193	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TT7	89.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00838 (show subtarget assignments)	1	soluble	SACOL0833	57284295	clpP	ATP-dependent Clp protease, proteolytic ...	195	Drug Target Function	Phase 2: March 2008	3QWD	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02028 (show subtarget assignments)	1	in_pdb 3Q7H	CBU_0738	29541338	clpP	ATP-dependent Clp protease, proteolytic ...	195	Conserved; Drug target functions	Phase 3: June 2008	3Q7H	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01974 (show subtarget assignments)	1	soluble	lmo2468	16804506	clpP	ATP-dependent Clp protease proteolytic s...	198	Known virulence-Protease; PMID:11447171; Presence of Protease Motifs	Phase 3: June 2008	3QWD	76.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP92089 (show subtarget assignments)	8	selected	TGME49_118320	237840947		ATP-dependent Clp protease proteolytic s...	310	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP00697 (show subtarget assignments)	1	soluble	SACOL2563	57285245		ATP-dependent Clp protease, putative	701	Drug Target Function	Phase 2: March 2008	1QVR	43.1%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02821 (show subtarget assignments)	1	in_pdb 3P2L	FTT0624	56707749	clpP	ATP-dependent Clp protease subunit P [Fr...	201	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3P2L	98.5%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05759 (show subtarget assignments)	1	cloned	lmo1759	16803799	pcrA	ATP-dependent DNA helicase [Listeria mon...	733	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	65.1%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP91395 (show subtarget assignments)	8	cloned	VV1_1082	27364505		ATP-dependent DNA helicase Rep [Vibrio v...	528	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1UAA	71%	Vibrio vulnificus

IDP91451 (show subtarget assignments)	8	expressed	VV1_0382	27363851		ATP-dependent endonuclease [Vibrio vulni...	530	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02738 (show subtarget assignments)	1	cloned	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP02184 (show subtarget assignments)	1	expressed	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP01349
(show subtarget assignments)

1

purified

VCA0253

15601021

antibiotic acetyltransferase

232

Drug Target Function

Phase 2: March 2008

3EEV

37.1%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01510
(show subtarget assignments)

1

purified

VC0731

15640750

antioxidant, AhpC/Tsa family

207

Conserved Gene / Pathway

Phase 2: March 2008

1ZOF

55.1%

Vibrio cholerae

Cellular processes

Detoxification

IDP01024
(show subtarget assignments)

1

purified

STM1172

16764528

flgM

anti-sigma28 factor FlgM

97

Conserved Gene / Pathway

Phase 2: March 2008

Salmonella enterica

Cell envelope

Surface structures

IDP04053
(show subtarget assignments)

1

cloned

CPF_2307

110801393

spoIIAA

anti-sigma F factor antagonist [Clostrid...

111

conserved gene; putative drug target function;

Phase 4: April 2009

1TH8

45%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP91189
(show subtarget assignments)

1

in_pdb
3R80
3R81

AAW59417

57918602

aph(2'')-Id

APH(2'')-Id [Enterococcus faecium]

301

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LZH

100%

Enterococcus faecium

IDP92066
(show subtarget assignments)

8

selected

ABO93620

144228223

GAPDH2

apicoplast glyceraldehyde-3-phosphate de...

995

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP91091
(show subtarget assignments)

8

cloned

APL_0387

126096663

kpsF

arabinose-5-phosphate isomerase [Actinob...

311

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

27%

Actinobacillus pleuropneumoniae

IDP00526
(show subtarget assignments)

1

purified

YPO1351

16121631

artI

arginine-binding periplasmic protein 1 p...

243

Conserved Gene / Pathway

Phase 2: March 2008

2Y7I

52.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP91383
(show subtarget assignments)

8

soluble

VV1_1467

27364851

arginine deiminase [Vibrio vulnificus CM...

406

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1RXX

45.3%

Vibrio vulnificus

IDP90289
(show subtarget assignments)

8

purified

TGME49_094270

211967870

arginine methyltransferase protein, puta...

660

Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...

Community Requests

2Y1W

24.5%

Toxoplasma gondii

IDP90290
(show subtarget assignments)

8

purified

TGME49_019520

211968370

arginine N-methyltransferase 1 [Toxoplas...

392

The histone arginine methyl-transferase TgPRMT1 methylates histone 4 (R3). Whe...

Community Requests

1OR8

44.9%

Toxoplasma gondii

IDP91417
(show subtarget assignments)

8

in_pdb
3V4G

VV1_0674

27364131

arginine repressor [Vibrio vulnificus CM...

156

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3V4G

100%

Vibrio vulnificus

IDP00944
(show subtarget assignments)

1

crystallized

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01901
(show subtarget assignments)

1

purified

STM0890

16764251

artI

arginine transport system [Salmonella ty...

243

Conserved; Drug target functions

Phase 3: June 2008

2Y7I

51.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00537
(show subtarget assignments)

1

purified

YPO3924

16124055

argH

argininosuccinate lyase

457

Conserved Gene / Pathway

Phase 2: March 2008

1TJ7

88.8%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP02396
(show subtarget assignments)

1

purified

GBAA3604

47528890

argH-1

argininosuccinate lyase [Bacillus anthra...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E9F

27.5%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP04429
(show subtarget assignments)

1

purified

GBAA4879

47530172

argH-2

argininosuccinate lyase [Bacillus anthra...

462

conserved gene; putative drug target function;

Phase 4: April 2009

2E9F

48.3%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP90621
(show subtarget assignments)

8

soluble

Cj0931c

15792260

argH

argininosuccinate lyase [Campylobacter j...

460

Predicted Essential

Community Requests

1AUW

44.8%

Campylobacter jejuni

IDP02815
(show subtarget assignments)

1

soluble

GBAA4880

47530173

argG

argininosuccinate synthase [Bacillus ant...

401

Conserved; Drug target functions

Phase 3: June 2008

1VL2

46.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP90768
(show subtarget assignments)

8

purified

Cj0665c

15792020

argG

argininosuccinate synthase [Campylobacte...

406

Predicted Essential

Community Requests

1J1Z

57.9%

Campylobacter jejuni

IDP05453
(show subtarget assignments)

1

purified

BAS5213

49188199

-

arginyl-tRNA synthetase [Bacillus anthra...

556

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.8%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05141
(show subtarget assignments)

1

cloned

BAS2021

49185032

argS

arginyl-tRNA synthetase [Bacillus anthra...

562

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1BS2

36.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP92024
(show subtarget assignments)

8

selected

TGME49_010840

237843883

arginyl-tRNA synthetase, putative [Toxop...

607

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP05255
(show subtarget assignments)

1

purified

SACOL0663

57650073

argS

arginyl-tRNA synthetase [Staphylococcus ...

553

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90894
(show subtarget assignments)

8

expressed

YPO2046

16122285

argS

arginyl-tRNA synthetase [Yersinia pestis...

576

Predicted Essential

Community Requests

1BS2

31.1%

Yersinia pestis

IDP04704
(show subtarget assignments)

1

cloned

YPO0322

115346138

tyrB

aromatic-amino-acid aminotransferase [Ye...

397

conserved gene; putative drug target function;

Phase 4: April 2009

3TAT

75.6%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01300
(show subtarget assignments)

1

in_pdb
3F0I

VC2165

15642164

arsenate reductase

116

Conserved Gene / Pathway

Phase 2: March 2008

3F0I

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP04016
(show subtarget assignments)

1

purified

CPF_0834

110798754

arsC

arsenate reductase ArsC [Clostridium per...

132

conserved gene; putative drug target function;

Phase 4: April 2009

2L17

40.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP01783
(show subtarget assignments)

1

expressed

FTT0824

56707935

arsC1

arsenate reductase [Francisella tularens...

117

Drug Target

Phase 3: June 2008

3GKX

25.6%

Francisella tularensis

Unknown function

General

IDP00841
(show subtarget assignments)

1

purified

SACOL0876

57284336

arsenate reductase, putative

118

Conserved Gene / Pathway

Phase 2: March 2008

3FZ4

41.5%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00724
(show subtarget assignments)

1

purified

SACOL1822

57286255

arsR

arsenical resistance operon repressor

104

Conserved Gene / Pathway

Phase 2: March 2008

1R1T

31.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP02193
(show subtarget assignments)

1

purified

FTT0868c

56707972

arsenical restistance operon repressor [...

121

Drug Target

Phase 3: June 2008

3JTH

22.3%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP91336
(show subtarget assignments)

8

expressed

VV2_0152

27366608

arylsulfatase regulator [Vibrio vulnific...

434

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP04523
(show subtarget assignments)

1

cloned

STM0884_1_447

16764245

ulaA

ascorbate-specific PTS system enzyme IIC...

447

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP01728
(show subtarget assignments)

1

expressed

CBU_0840

29541434

asnB-2

asparagine synthetase B, glutamine-hydro...

637

Conserved; Drug target functions

Phase 3: June 2008

1Q15

13%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01984
(show subtarget assignments)

1

expressed

CBU_0831

29541425

asnB-1

asparagine synthetase B, glutamine-hydro...

632

Conserved; Drug target functions

Phase 3: June 2008

1CT9

18.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04501
(show subtarget assignments)

1

cloned

VC0991

9655452

asparagine synthetase B, glutamine-hydro...

554

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CT9

75.3%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP02245
(show subtarget assignments)

1

cloned

GBAA1751

47527043

asnO-2

asparagine synthetase, glutamine-hydroly...

607

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CT9

25.9%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP05569
(show subtarget assignments)

1

soluble

BAS4454

49187449

-

asparaginyl-tRNA synthetase [Bacillus an...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

35.9%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05239
(show subtarget assignments)

1

cloned

lmo1896

16803935

ansB

asparaginyl-tRNA synthetase [Listeria mo...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.3%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05209
(show subtarget assignments)

1

purified

SACOL1494

57650409

asnC

asparaginyl-tRNA synthetase [Staphylococ...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.8%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90728
(show subtarget assignments)

8

cloned

YPO1412

16121692

asnC

asparaginyl-tRNA synthetase [Yersinia pe...

466

Predicted Essential

Community Requests

1X54

34.3%

Yersinia pestis

IDP04342
(show subtarget assignments)

1

cloned

GBAA1564

47526837

panD

aspartate alpha-decarboxylase [Bacillus ...

127

conserved gene; putative drug target function;

Phase 4: April 2009

2C45

52.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90506
(show subtarget assignments)

8

in_pdb
3PLX

Cj0296c

15791664

panD

aspartate alpha-decarboxylase [Campyloba...

126

Predicted Essential

Community Requests

3PLX

80.2%

Campylobacter jejuni

IDP02730
(show subtarget assignments)

1

in_pdb
3OUG

FTT1391

56708440

panD

aspartate alpha-decarboxylase [Francisel...

111

Drug Target

Phase 3: June 2008

3OUG

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90634
(show subtarget assignments)

8

purified

YPO3403

16123552

panD

aspartate alpha-decarboxylase [Yersinia ...

126

Predicted Essential

Community Requests

1PPY

78.6%

Yersinia pestis

IDP02669
(show subtarget assignments)

1

purified

GBAA1568

50196927

aspB

aspartate aminotransferase [Bacillus ant...

395

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J32

45.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02483
(show subtarget assignments)

1

cloned

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04167
(show subtarget assignments)

1

cloned

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP02640
(show subtarget assignments)

1

purified

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02192
(show subtarget assignments)

1

soluble

YPO0348

16120683

aspA

aspartate ammonia-lyase [Yersinia pestis...

478

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1JSW

89.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP90587
(show subtarget assignments)

8

in_pdb
3LXM

YPO3588

16123730

pyrB

aspartate carbamoyltransferase catalytic...

311

Predicted Essential

Community Requests

3LXM

100%

Yersinia pestis

IDP00670
(show subtarget assignments)

1

soluble

SACOL1212

57285955

pyrB

aspartate carbamoyltransferase catalytic...

293

Drug Target Function

Phase 2: March 2008

2AT2

55.6%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02775
(show subtarget assignments)

1

purified

GBAA4028

47529321

pyrB

aspartate carbamoyltransferase catalytic...

304

Conserved; Drug target functions

Phase 3: June 2008

3R7D

61.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90752
(show subtarget assignments)

8

soluble

Cj1098

15792423

pyrB

aspartate carbamoyltransferase catalytic...

295

Predicted Essential

Community Requests

2AT2

38.5%

Campylobacter jejuni

IDP91385
(show subtarget assignments)

8

soluble

VV1_1465

27364849

pyrB

aspartate carbamoyltransferase catalytic...

309

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2BE7

76.4%

Vibrio vulnificus

IDP04175
(show subtarget assignments)

1

purified

VC2511

9657094

aspartate carbamoyltransferase, regulato...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1D09

63.2%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04411
(show subtarget assignments)

1

soluble

YPO3589

218930599

pyrI

aspartate carbamoyltransferase regulator...

154

conserved gene; putative drug target function;

Phase 4: April 2009

1D09

77.3%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP92107
(show subtarget assignments)

8

selected

TGME49_091640

237838437

aspartate carbamoyltransferase [Toxoplas...

423

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP90746
(show subtarget assignments)

8

purified

Cj0582

15791942

lysC

aspartate kinase [Campylobacter jejuni s...

400

Predicted Essential

Community Requests

3AB4

48.9%

Campylobacter jejuni

IDP02060
(show subtarget assignments)

1

expressed

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01080
(show subtarget assignments)

0

work_stopped

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP90223
(show subtarget assignments)

1

expressed

SA1226

15926974

Asd

Aspartate semialdehyde dehydrogenase Asd...

329

This enzyme participates in glycine, serine and threonine metabolism and lysine ...

January 2009

2YV3

43.4%

Staphylococcus aureus

IDP02467
(show subtarget assignments)

1

soluble

GBAA3937

47529228

asd-2

aspartate-semialdehyde dehydrogenase [Ba...

348

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GYY

60.6%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04599
(show subtarget assignments)

1

cloned

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP90732
(show subtarget assignments)

8

soluble

Cj1023c

15792350

asd

aspartate-semialdehyde dehydrogenase [Ca...

343

Predicted Essential

Community Requests

2QZ9

45.8%

Campylobacter jejuni

IDP02042
(show subtarget assignments)

1

cloned

CBU_0875

29541467

asd

aspartate-semialdehyde dehydrogenase [Co...

340

Conserved; Drug target functions

Phase 3: June 2008

2QZ9

61.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02783
(show subtarget assignments)

1

expressed

FTT0425c

56707572

asd

aspartate-semialdehyde dehydrogenase [Fr...

364

Conserved; Drug target functions

Phase 3: June 2008

1NWC

50%

Francisella tularensis

Amino acid biosynthesis

Aspartate family

IDP90899
(show subtarget assignments)

8

soluble

YPO3949

16124077

asd

aspartate-semialdehyde dehydrogenase [Ye...

367

Predicted Essential

Community Requests

1BRM

83.4%

Yersinia pestis

IDP04155
(show subtarget assignments)

1

cloned

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP92103
(show subtarget assignments)

8

selected

TGME49_097970

237843837

aspartyl aminopeptidase, putative [Toxop...

506

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP90744
(show subtarget assignments)

8

expressed

Cj1059c

15792386

gatA

aspartyl/glutamyl-tRNA amidotransferase ...

453

Predicted Essential

Community Requests

3H0L

47.9%

Campylobacter jejuni

IDP90774
(show subtarget assignments)

8

purified

Cj1197c

15792521

gatB

aspartyl/glutamyl-tRNA amidotransferase ...

472

Predicted Essential

Community Requests

3H0L

49.2%

Campylobacter jejuni

IDP05333
(show subtarget assignments)

1

cloned

BAS2031

49185042

-

aspartyl-tRNA synthetase [Bacillus anthr...

432

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1N9W

49.5%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP04615
(show subtarget assignments)

1

cloned

BAS4297

49187293

aspartyl-tRNA synthetase [Bacillus anthr...

591

Proposed to be essential proteins

Phase 4: April 2009

1EQR

52.7%

Bacillus anthracis

IDP90630
(show subtarget assignments)

8

soluble

Cj0640c

15792000

aspS

aspartyl-tRNA synthetase [Campylobacter ...

583

Predicted Essential

Community Requests

1C0A

51.8%

Campylobacter jejuni

IDP05234
(show subtarget assignments)

1

cloned

lmo1519

16803559

aspS

aspartyl-tRNA synthetase [Listeria monoc...

591

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1EQR

52.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05303
(show subtarget assignments)

1

cloned

SACOL1685

57650511

aspS

aspartyl-tRNA synthetase [Staphylococcus...

588

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1C0A

54.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90878
(show subtarget assignments)

8

purified

VC1166

15641179

aspS

aspartyl-tRNA synthetase [Vibrio cholera...

591

Predicted Essential

Community Requests

1C0A

74.8%

Vibrio cholerae

IDP90838
(show subtarget assignments)

8

cloned

YPO2053

16122292

aspS

aspartyl-tRNA synthetase [Yersinia pesti...

598

Predicted Essential

Community Requests

1EQR

80.8%

Yersinia pestis

IDP01890
(show subtarget assignments)

1

cloned

Cj0063c

15791455

ATPase, ParA family [Campylobacter jejun...

288

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1HYQ

25.7%

Campylobacter jejuni

Cell envelope

Other

IDP91005
(show subtarget assignments)

8

soluble

y1936

22125828

ATP-binding component of a transport sys...

257

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

2ZU0

80.9%

Yersinia pestis

IDP04110
(show subtarget assignments)

1

expressed

YPO2440

218929529

yfeB

ATP-binding transport protein [Yersinia ...

296

virulence factor; conserved gene;

Phase 4: April 2009

3GFO

26.4%

Yersinia pestis

Unknown function

General

IDP01335
(show subtarget assignments)

1

soluble

VC1144

15641157

clpA

ATP-dependent Clp protease ATP-binding s...

756

Drug Target Function

Phase 2: March 2008

1KSF

77.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00663
(show subtarget assignments)

1

purified

SACOL0979

57285852

clpB

ATP-dependent Clp protease, ATP-binding ...

869

Drug Target Function

Phase 2: March 2008

1QVR

54.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02143
(show subtarget assignments)

1

expressed

CBU_0739

29541339

clpX

ATP-dependent Clp protease, ATP-binding ...

422

Conserved; Drug target functions

Phase 3: June 2008

3HTE

59.5%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01433
(show subtarget assignments)

1

soluble

VC1922

15641924

clpP

ATP-dependent Clp protease proteolytic s...

200

Drug Target Function

Phase 2: March 2008

1TYF

76%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01105
(show subtarget assignments)

1

soluble

BA_2788

67460529

ATP-dependent Clp protease proteolytic s...

193

Drug Target Function

Phase 2: March 2008

3TT7

67.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01711
(show subtarget assignments)

1

expressed

GBAA5380

47530690

clpP

ATP-dependent Clp protease proteolytic s...

193

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TT7

89.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00838
(show subtarget assignments)

1

soluble

SACOL0833

57284295

clpP

ATP-dependent Clp protease, proteolytic ...

195

Drug Target Function

Phase 2: March 2008

3QWD

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02028
(show subtarget assignments)

1

in_pdb
3Q7H

CBU_0738

29541338

clpP

ATP-dependent Clp protease, proteolytic ...

195

Conserved; Drug target functions

Phase 3: June 2008

3Q7H

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01974
(show subtarget assignments)

1

soluble

lmo2468

16804506

clpP

ATP-dependent Clp protease proteolytic s...

198

Known virulence-Protease; PMID:11447171; Presence of Protease Motifs

Phase 3: June 2008

3QWD

76.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP92089
(show subtarget assignments)

8

selected

TGME49_118320

237840947

ATP-dependent Clp protease proteolytic s...

310

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP00697
(show subtarget assignments)

1

soluble

SACOL2563

57285245

ATP-dependent Clp protease, putative

701

Drug Target Function

Phase 2: March 2008

1QVR

43.1%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02821
(show subtarget assignments)

1

in_pdb
3P2L

FTT0624

56707749

clpP

ATP-dependent Clp protease subunit P [Fr...

201

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3P2L

98.5%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05759
(show subtarget assignments)

1

cloned

lmo1759

16803799

pcrA

ATP-dependent DNA helicase [Listeria mon...

733

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

65.1%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP91395
(show subtarget assignments)

8

cloned

VV1_1082

27364505

ATP-dependent DNA helicase Rep [Vibrio v...

528

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1UAA

71%

Vibrio vulnificus

IDP91451
(show subtarget assignments)

8

expressed

VV1_0382

27363851

ATP-dependent endonuclease [Vibrio vulni...

530

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP02738
(show subtarget assignments)

1

cloned

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP02184
(show subtarget assignments)

1

expressed

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division