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Targets
Filter Targets:
Selection Phase:
No Filter
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM 10
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
Clostridium difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
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1
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8
Keyword:
Type Keyword
Stage:
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cloned
crystallized
crystal_structure
diffraction
expressed
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
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CSGID ID
Priority
stage
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90541
(
show subtarget assignments
)
8
purified
VC0297
15640325
3-dehydroquinate dehydratase [Vibrio cho...
150
Predicted Essential
Community Requests
3LWZ
70.7%
Vibrio cholerae
IDP01109
(
show subtarget assignments
)
1
soluble
GBAA_pXO1_0148
47566460
hypothetical protein GBAA_pXO1_0148
150
Virulence Associated Factor
Phase 2: March 2008
3PMD
100%
Bacillus anthracis
IDP91708
(
show subtarget assignments
)
8
selected
NP_005615
22538796
CCL25
C-C motif chemokine 25 isoform 1 precurs...
150
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2L4N
18.7%
Homo sapiens
IDP01116
(
show subtarget assignments
)
1
expressed
BA_1693
30255984
glycosyl transferase, group 2 family pro...
150
Drug Target Function
Phase 2: March 2008
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90771
(
show subtarget assignments
)
8
in_pdb
3LWZ
YPO3660
16123803
aroQ
3-dehydroquinate dehydratase [Yersinia p...
150
Predicted Essential
Community Requests
3LWZ
100%
Yersinia pestis
IDP91595
(
show subtarget assignments
)
8
selected
AAC64366
3661463
arr-2
ribosylating transferase ARR-2 [Pseudomo...
150
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2HW2
51.3%
Pseudomonas aeruginosa
IDP90991
(
show subtarget assignments
)
8
cloned
y1282
22125182
formate acetyltransferase [Yersinia pest...
150
other biological interest /
stress-response protein replacind PflA in PflA/PflB complex
Community Requests
1CM5
40%
Yersinia pestis
IDP00158
(
show subtarget assignments
)
1
soluble
VC0830
15640847
tcpQ
toxin co-regulated pilus biosynthesis pr...
150
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP00156
(
show subtarget assignments
)
1
soluble
VC0407
15640434
mshF
MSHA biogenesis protein MshF
150
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP91372
(
show subtarget assignments
)
8
cloned
VV1_2222
27365548
hypothetical protein VV1_2222 [Vibrio vu...
150
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00321
(
show subtarget assignments
)
1
purified
Cj1105
15792430
smpB
SsrA-binding protein
150
Drug Target Function
Phase 2: March 2008
1P6V
47.3%
Campylobacter jejuni
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP90355
(
show subtarget assignments
)
8
in_pdb
3N08
CT736
15605469
ybcL
hypothetical protein CT736 [Chlamydia tr...
150
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3N08
100%
Chlamydia trachomatis
IDP02565
(
show subtarget assignments
)
1
soluble
CBU_0648
29541249
ribH
6,7-dimethyl-8-ribityllumazine synthase ...
151
Conserved; Drug target functions
Phase 3: June 2008
1VSW
47.7%
Coxiella burnetii
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP05576
(
show subtarget assignments
)
1
cloned
BA_0536
30254062
bcP
bacterioferritin comigratory protein [Ba...
151
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3DRN
41.7%
Bacillus anthracis
Cellular processes: Detoxification
IDP04226
(
show subtarget assignments
)
1
cloned
CPF_0171
110799571
luxS
S-ribosylhomocysteinase [Clostridium per...
151
conserved gene; putative drug target function;
Phase 4: April 2009
1J6W
51%
Clostridium perfringens
Cellular processes
Other
IDP91376
(
show subtarget assignments
)
8
soluble
VV1_1694
27365055
hypothetical protein VV1_1694 [Vibrio vu...
151
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1IB8
29.8%
Vibrio vulnificus
IDP90217
(
show subtarget assignments
)
8
soluble
MYXV_gp004
9633795
m003.1L
m003.1L, m3.1
151
similar to VACV-Cop:B22R, member of Poxvirus A4/B15 family. This is a family of ...
Community Requests
2VVY
29.8%
Myxoma virus
unknown
0
IDP01826
(
show subtarget assignments
)
1
in_pdb
3LAY
STM4172
16767426
zraP
zinc resistance protein [Salmonella typh...
151
Conserved; Drug target functions
Phase 3: June 2008
3LAY
100%
Salmonella enterica
Unknown function
General
IDP90751
(
show subtarget assignments
)
8
cloned
Cj1291c
15792614
accB
acetyl-CoA carboxylase biotin carboxyl c...
151
Predicted Essential
Community Requests
1A6X
27.2%
Campylobacter jejuni
IDP05402
(
show subtarget assignments
)
1
cloned
BA_4463
30258957
comGD
comG operon protein 4 [Bacillus anthraci...
151
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cellular processes: DNA transformation
IDP01817
(
show subtarget assignments
)
1
cloned
STM1143
16764499
csgB
curlin minor subunit [Salmonella typhimu...
151
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Pathogenesis
IDP01778
(
show subtarget assignments
)
1
cloned
YPO3689
16123828
putative ribonuclease [Yersinia pestis C...
152
Conserved; CD; Drug target functions
Phase 3: June 2008
1BNE
42.1%
Yersinia pestis
Transcription
Degradation of RNA
IDP91976
(
show subtarget assignments
)
8
selected
HMPREF0837_10616
298502118
hypothetical protein HMPREF0837_10616 [S...
152
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP00883
(
show subtarget assignments
)
1
expressed
STM1755
16765099
ychJ
hypothetical protein STM1755
152
Conserved Gene / Pathway
Phase 2: March 2008
2JQ5
30.9%
Salmonella enterica
Protein synthesis
tRNA aminoacylation
IDP04696
(
show subtarget assignments
)
1
cloned
YPCD1.15c
5832437
YPCD1.15c
hypothetical protein YPCD1.15c [Yersinia...
152
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP00160
(
show subtarget assignments
)
1
soluble
VC0834
15640851
tcpS
toxin co-regulated pilus biosynthesis pr...
152
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP05417
(
show subtarget assignments
)
1
purified
BA_4788
30259274
conserved domain protein [Bacillus anthr...
152
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2K78
24.3%
Bacillus anthracis
Hypothetical proteins: Domain
IDP91505
(
show subtarget assignments
)
8
soluble
VP1669
28898443
putative type III secretion protein YscO...
153
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP05658
(
show subtarget assignments
)
1
cloned
lmo0207
16802253
-
hypothetical protein lmo0207 [Listeria m...
153
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2JOE
34%
Listeria monocytogenes
Viral functions: General
IDP01107
(
show subtarget assignments
)
1
soluble
BA_2250
30256894
heat shock protein, Hsp20 family
153
Conserved Gene / Pathway
Phase 2: March 2008
3AAB
24.2%
Bacillus anthracis
Protein fate
Protein folding and stabilization
IDP05460
(
show subtarget assignments
)
1
cloned
BA_0985
30254723
putative lipoprotein [Bacillus anthracis...
153
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP90365
(
show subtarget assignments
)
8
cloned
CT_102
3328499
hypothetical protein [Chlamydia trachoma...
153
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90374
(
show subtarget assignments
)
8
expressed
CT_338
3328758
hypothetical protein [Chlamydia trachoma...
153
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP00166
(
show subtarget assignments
)
1
expressed
VC1450
15641461
rtxC
RTX toxin activating protein
153
Virulence
Phase 1: October 2007
Vibrio cholerae
Cellular processes
Pathogenesis
IDP02735
(
show subtarget assignments
)
1
soluble
GBAA4334
47529631
ribH
riboflavin synthase subunit beta [Bacill...
153
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1VSW
100%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP90112
(
show subtarget assignments
)
8
soluble
MPXV_ZAI1979_005_019
68449093
unknown [Monkeypox virus]
153
similar to VACV-COP-C6L, MPXV-ZAI96-D11L
Community Requests
Monkeypox virus
IDP91225
(
show subtarget assignments
)
8
selected
NT04EC4200
26110357
pshM
Putative general secretion pathway prote...
153
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
Protein fate: Protein and peptide secretion and trafficking
IDP04435
(
show subtarget assignments
)
1
expressed
YPCD1.91n
40548798
hypothetical protein YPCD1.91n [Yersinia...
154
virulence factor;
Phase 4: April 2009
Yersinia pestis
IDP90778
(
show subtarget assignments
)
8
soluble
Cj0575
15791935
ilvH
acetolactate synthase 3 regulatory subun...
154
Predicted Essential
Community Requests
2F1F
40.3%
Campylobacter jejuni
IDP91420
(
show subtarget assignments
)
8
cloned
VV1_0667
27364124
hypothetical protein VV1_0667 [Vibrio vu...
154
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05362
(
show subtarget assignments
)
1
expressed
BA_1821
30256093
conserved domain protein [Bacillus anthr...
154
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP91236
(
show subtarget assignments
)
8
selected
NT04EC1226
26107467
Conserved hypothetical protein [Escheric...
154
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
Hypothetical proteins: Conserved
IDP04411
(
show subtarget assignments
)
1
soluble
YPO3589
218930599
pyrI
aspartate carbamoyltransferase regulator...
154
conserved gene; putative drug target function;
Phase 4: April 2009
1D09
77.3%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP00747
(
show subtarget assignments
)
0
work_stopped
SACOL1768
57286203
GAF domain protein
154
Drug Target Function
Phase 2: March 2008
3KSF
98.7%
Staphylococcus aureus
Unknown function
General
IDP90519
(
show subtarget assignments
)
8
purified
Cj0383c
15791750
ribH
riboflavin synthase subunit beta [Campyl...
154
Predicted Essential
Community Requests
1HQK
51.9%
Campylobacter jejuni
IDP05520
(
show subtarget assignments
)
1
soluble
CD1822
126699430
bcp
putative thiol peroxidase (bacterioferri...
154
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3DRN
42.6%
Clostridium difficile
Cellular processes: Detoxification
IDP01473
(
show subtarget assignments
)
1
soluble
VC2653
15642648
preprotein translocase subunit SecB
154
Conserved Gene / Pathway
Phase 2: March 2008
1QYN
66.2%
Vibrio cholerae
Protein fate
Protein and peptide secretion and trafficking
IDP04009
(
show subtarget assignments
)
1
cloned
VC2277
15642275
xanthine-guanine phosphoribosyltransfera...
154
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1A95
68.8%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Salvage of nucleosides and nucleotides
IDP90375
(
show subtarget assignments
)
8
purified
CT_296
3328711
hypothetical protein [Chlamydia trachoma...
155
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3QH6
98.1%
Chlamydia trachomatis
IDP05096
(
show subtarget assignments
)
1
cloned
CD0015
126697581
putative cytosine/adenosine deaminase [C...
155
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1WWR
48.1%
Clostridium difficile
Transport and binding proteins: Unknown substrate
IDP92074
(
show subtarget assignments
)
8
selected
TGME49_095350
237844373
nucleoside diphosphate kinase, putative ...
155
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
IDP90092
(
show subtarget assignments
)
8
purified
ZZZ_0008
155
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP05454
(
show subtarget assignments
)
1
purified
BA_0190
30253697
putative lipoprotein [Bacillus anthracis...
155
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05486
(
show subtarget assignments
)
1
soluble
BA_4573
30259076
putative lipoprotein [Bacillus anthracis...
155
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP01956
(
show subtarget assignments
)
1
cloned
STM2061
16765391
sbmC
DNA gyrase inhibitor [Salmonella typhimu...
155
Conserved; Drug target homolg; Drug target functions
Phase 3: June 2008
1JYH
71%
Salmonella enterica
Unknown function
General
IDP04175
(
show subtarget assignments
)
1
purified
VC2511
9657094
aspartate carbamoyltransferase, regulato...
155
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1D09
63.2%
Vibrio cholerae
Purines, pyrimidines, nucleosides, and nucleotides
Pyrimidine ribonucleotide biosynthesis
IDP01914
(
show subtarget assignments
)
1
purified
FTT0160
56707330
nudH
dinucleoside polyphosphate hydrolase [Fr...
155
Drug Target
Phase 3: June 2008
2KDV
54.2%
Francisella tularensis
Purines, pyrimidines, nucleosides, and nucleotides
Salvage of nucleosides and nucleotides
IDP04091
(
show subtarget assignments
)
1
cloned
CPF_1278
110799680
putative lipoprotein [Clostridium perfri...
155
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cell envelope
Other
IDP02621
(
show subtarget assignments
)
1
cloned
FTT0913
56708014
hypothetical protein FTT0913 [Francisell...
155
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP05410
(
show subtarget assignments
)
1
soluble
BA_2500
30257128
hypothetical protein BA_2500 [Bacillus a...
156
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91324
(
show subtarget assignments
)
8
cloned
VV2_0293
27366739
methyl-accepting chemotaxis protein [Vib...
156
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91417
(
show subtarget assignments
)
8
in_pdb
3V4G
VV1_0674
27364131
arginine repressor [Vibrio vulnificus CM...
156
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3V4G
100%
Vibrio vulnificus
IDP01508
(
show subtarget assignments
)
1
expressed
VCA0127
15600898
ribose ABC transporter protein
156
Conserved Gene / Pathway
Phase 2: March 2008
3DSA
48.1%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01318
(
show subtarget assignments
)
1
in_pdb
3IQ1
VC0139
15640170
DPS family protein
156
Conserved Gene / Pathway
Phase 2: March 2008
3IQ1
100%
Vibrio cholerae
Cellular processes
Adaptations to atypical conditions
IDP00402
(
show subtarget assignments
)
1
purified
YPO3182
16123344
ribH
riboflavin synthase subunit beta
156
Conserved Gene / Pathway
Phase 2: March 2008
3MK3
82.1%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP02784
(
show subtarget assignments
)
1
expressed
PSLT072
17233503
putative transglycosylase [Salmonella ty...
156
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP05394
(
show subtarget assignments
)
1
cloned
BA_3228
30257791
putative lipoprotein [Bacillus anthracis...
156
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP00920
(
show subtarget assignments
)
1
purified
STM0417
16763797
ribH
riboflavin synthase subunit beta
156
Conserved Gene / Pathway
Phase 2: March 2008
3MK3
100%
Salmonella enterica
Biosynthesis of cofactors, prosthetic groups, and carriers
Riboflavin, FMN, and FAD
IDP05753
(
show subtarget assignments
)
1
cloned
lmo0461
16802505
-
hypothetical protein lmo0461 [Listeria m...
157
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP01688
(
show subtarget assignments
)
0
work_stopped
Cj1313
15792636
GNAT family acetyltransferase [Campyloba...
157
Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950
Phase 3: June 2008
3EG7
22.9%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP91714
(
show subtarget assignments
)
8
selected
NP_006734
5803137
RBM3
putative RNA-binding protein 3 [Homo sap...
157
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1X5S
41.4%
Homo sapiens
IDP02513
(
show subtarget assignments
)
1
soluble
GBAA0258
47525517
hypothetical protein GBAA0258 [Bacillus ...
157
Conserved;
Phase 3: June 2008
1FL9
30.6%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP02175
(
show subtarget assignments
)
1
cloned
YPO3064
16123241
bcp
thioredoxin-dependent thiol peroxidase [...
157
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3DRN
36.9%
Yersinia pestis
Transport and binding proteins
Cations and iron carrying compounds
IDP02109
(
show subtarget assignments
)
1
purified
YPO1186
16121481
hypothetical protein YPO1186 [Yersinia p...
157
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Hypothetical proteins
Conserved
IDP00336
(
show subtarget assignments
)
1
cloned
FTT1186
56708252
smpB
SsrA-binding protein
157
Drug Target Function
Phase 2: March 2008
1P6V
48.4%
Francisella tularensis
Protein synthesis
Other
IDP04552
(
show subtarget assignments
)
1
cloned
CPF_2913
110799629
msrA
methionine sulfoxide reductase A [Clostr...
157
conserved gene; putative drug target function;
Phase 4: April 2009
3BQE
52.2%
Clostridium perfringens
Cellular processes
Adaptations to atypical conditions
IDP05659
(
show subtarget assignments
)
1
cloned
lmo0236
16802282
-
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
157
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1GX1
61.8%
Listeria monocytogenes
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
IDP05757
(
show subtarget assignments
)
1
cloned
lmo0881
16802922
-
hypothetical protein lmo0881 [Listeria m...
159
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP05516
(
show subtarget assignments
)
1
soluble
CD1697
126699303
ribH
riboflavin synthase beta chain (6,7-dime...
158
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1RVV
66.5%
Clostridium difficile
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
IDP90535
(
show subtarget assignments
)
8
soluble
VC2695
15642690
rRNA methylase [Vibrio cholerae O1 biova...
158
Predicted Essential
Community Requests
3N4J
58.5%
Vibrio cholerae
IDP91905
(
show subtarget assignments
)
8
selected
SpneCM_010100005473
298255048
hypothetical protein SpneCM_05473 [Strep...
158
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP01381
(
show subtarget assignments
)
1
soluble
VC0529
15640551
ispF
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
158
Drug Target Function
Phase 2: March 2008
1GX1
74.7%
Vibrio cholerae
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP90508
(
show subtarget assignments
)
8
purified
Cj0767c
15792105
coaD
phosphopantetheine adenylyltransferase [...
158
Predicted Essential
Community Requests
3NV7
53.8%
Campylobacter jejuni
IDP90979
(
show subtarget assignments
)
8
cloned
y0636
22124550
hypothetical protein y0636 [Yersinia pes...
158
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
2Y75
24.1%
Yersinia pestis
IDP05492
(
show subtarget assignments
)
1
cloned
BA_3540
30258075
conserved hypothetical protein [Bacillus...
158
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP90363
(
show subtarget assignments
)
8
cloned
CT_066
3328460
hypothetical protein [Chlamydia trachoma...
158
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02265
(
show subtarget assignments
)
1
cloned
YPO1303
16121585
psaA
pH 6 antigen precursor (antigen 4) (adhe...
158
Involved in virulence; Vaccine TargetDrug target functions
Phase 3: June 2008
Yersinia pestis
Cell envelope
Other
IDP01181
(
show subtarget assignments
)
1
purified
BA_0085
38372318
2-C-methyl-D-erythritol 2,4-cyclodiphosp...
158
Drug Target Function
Phase 2: March 2008
3F6M
64.6%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02178
(
show subtarget assignments
)
1
soluble
FTT0032
56707212
nuoB
NADH dehydrogenase subunit B [Francisell...
158
Drug Target
Phase 3: June 2008
2FUG
53.2%
Francisella tularensis
Energy metabolism
Electron transport
IDP90085
(
show subtarget assignments
)
8
purified
ZZZ_0001
158
This protein is a component of a type VI secretion system of enteroaggregative E...
Community Requests
Escherichia coli
IDP02053
(
show subtarget assignments
)
1
soluble
YPO3699
16123838
hypothetical protein YPO3699 [Yersinia p...
158
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3OD9
32.9%
Yersinia pestis
Cell envelope
Other
IDP90549
(
show subtarget assignments
)
8
in_pdb
3L92
3L93
YPO0053
16120406
coaD
phosphopantetheine adenylyltransferase [...
159
Predicted Essential
Community Requests
3L92
100%
Yersinia pestis
IDP05465
(
show subtarget assignments
)
1
cloned
BA_1580
30255880
conserved hypothetical protein [Bacillus...
159
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP00993
(
show subtarget assignments
)
0
work_stopped
STM2250
16765578
ccmE
cytochrome c-type biogenesis protein Ccm...
159
Conserved Gene / Pathway
Phase 2: March 2008
1SR3
68.6%
Salmonella enterica
Transport and binding proteins
Amino acids, peptides and amines
IDP91915
(
show subtarget assignments
)
8
selected
SpneCM_010100007341
298255399
histidine triad protein PhtA/B [Streptoc...
159
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91549
(
show subtarget assignments
)
8
cloned
CPF_1846
110800166
hypothetical protein CPF_1846 [Clostridi...
159
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Clostridium perfringens
IDP91463
(
show subtarget assignments
)
8
expressed
VV1_0079
27363564
bacteriophage phi gp55-like protein [Vib...
159
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05167
(
show subtarget assignments
)
1
purified
lmo1333
16803373
-
hypothetical protein lmo1333 [Listeria m...
153
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP90428
(
show subtarget assignments
)
8
cloned
CT_849
3329321
hypothetical protein [Chlamydia trachoma...
159
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP04300
(
show subtarget assignments
)
1
purified
CPF_0672
110798984
purE
phosphoribosylaminoimidazole carboxylase...
159
conserved gene; putative drug target function;
Phase 4: April 2009
1O4V
51.6%
Clostridium perfringens
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
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