Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02814 (show subtarget assignments)	1	cloned	FTT0709	56707828	eno	enolase (2-phosphoglycerate dehydratase)...	456	Conserved; Drug target functions	Phase 3: June 2008	1IYX	60.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02817 (show subtarget assignments)	1	cloned	lmo2185	16804224		hypothetical protein lmo2185 [Listeria m...	569	Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...	Phase 3: June 2008	2O6P	8.4%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02822 (show subtarget assignments)	1	cloned	GBAA4819	47778330	infC	translation initiation factor IF-3 [Baci...	186	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TIG	40.9%	Bacillus anthracis	Protein synthesis	Translation factors

IDP02827 (show subtarget assignments)	1	cloned	FTT1508c	56708546	relA	GTP pyrophosphokinase [Francisella tular...	647	Drug Target	Phase 3: June 2008	1VJ7	20.1%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02828 (show subtarget assignments)	1	cloned	GBAA4243	47529536		hypothetical protein GBAA4243 [Bacillus ...	205	Drug target motif;	Phase 3: June 2008			Bacillus anthracis	N/A	N/A

IDP02829 (show subtarget assignments)	1	cloned	GBAA4382	47529677	bfmbB	branched-chain alpha-keto acid dehydroge...	439	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.4%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02833 (show subtarget assignments)	1	cloned	GBAA4561	47529857	aroE	shikimate 5-dehydrogenase [Bacillus anth...	308	Conserved; Drug target functions	Phase 3: June 2008	2EGG	49.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP04003 (show subtarget assignments)	1	cloned	BAS0126	49183160		50S ribosomal protein L18 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1OVY	75.8%	Bacillus anthracis

IDP04004 (show subtarget assignments)	1	cloned	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP04006 (show subtarget assignments)	1	cloned	CPF_1351	110800739		putative lipoprotein [Clostridium perfri...	264	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04008 (show subtarget assignments)	1	cloned	YPO0906	218928079	gcsH	glycine cleavage system protein H [Yersi...	128	conserved gene; putative drug target function;	Phase 4: April 2009	3A7A	75%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04009 (show subtarget assignments)	1	cloned	VC2277	15642275		xanthine-guanine phosphoribosyltransfera...	154	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A95	68.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP04010 (show subtarget assignments)	1	cloned	CPF_2393	110798628	minD	septum site-determining protein MinD [Cl...	265	conserved gene; putative drug target function;	Phase 4: April 2009	3Q9L	43.4%	Clostridium perfringens	Cellular processes	Cell division

IDP04011 (show subtarget assignments)	1	cloned	CPF_2475	110800353		stage II sporulation protein R [Clostrid...	209	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04012 (show subtarget assignments)	1	cloned	CPF_2355	110800506	virJ	sensor histidine kinase [Clostridium per...	482	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	15.4%	Clostridium perfringens	Cellular processes	Pathogenesis

IDP04013 (show subtarget assignments)	1	cloned	STM2913_1_498	16766219		putative permease [Salmonella typhimuriu...	498	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04017 (show subtarget assignments)	1	cloned	CPF_1035	110799411		putative lipoprotein [Clostridium perfri...	309	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04018 (show subtarget assignments)	1	cloned	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04019 (show subtarget assignments)	1	cloned	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04020 (show subtarget assignments)	1	cloned	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04022 (show subtarget assignments)	1	cloned	BAS0095	49183129		preprotein translocase subunit SecE [Bac...	59	Proposed to be essential proteins	Phase 4: April 2009	3DIN	33.9%	Bacillus anthracis

IDP04023 (show subtarget assignments)	1	cloned	YPO0511a	115346321		hypothetical protein [Yersinia pestis CO...	121	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04024 (show subtarget assignments)	1	cloned	BAS5319	49188303		DNA-binding response regulator YycF [Bac...	235	Proposed to be essential proteins	Phase 4: April 2009	2OQR	47.7%	Bacillus anthracis

IDP04027 (show subtarget assignments)	1	cloned	BAS4637	49187628		leucyl-tRNA synthetase [Bacillus anthrac...	802	Proposed to be essential proteins	Phase 4: April 2009	1H3N	45.9%	Bacillus anthracis

IDP04030 (show subtarget assignments)	1	cloned	YPO2532	115348229		hypothetical protein [Yersinia pestis CO...	70	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04031 (show subtarget assignments)	1	cloned	CBU_A0011	29648123		hypothetical protein CBUA0011 [Coxiella ...	56	drug target;	Phase 4: April 2009			Coxiella burnetii	Hypothetical proteins	Domain

IDP04032 (show subtarget assignments)	1	cloned	CPF_2081	110798910		stage III sporulation protein AG [Clostr...	201	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04036 (show subtarget assignments)	1	cloned	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04039 (show subtarget assignments)	1	cloned	CPF_2446	110800060	spoIIID	stage III sporulation protein D [Clostri...	83	conserved gene; putative drug target function;	Phase 4: April 2009	2L0K	60.2%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04040 (show subtarget assignments)	1	cloned	CPF_1068	110800949	cotJC	spore coat protein CotJC [Clostridium pe...	188	conserved gene; putative drug target function;	Phase 4: April 2009	1JKU	34.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04041 (show subtarget assignments)	1	cloned	YPCD1.16c	5832438	YPCD1.16c	hypothetical protein YPCD1.16c [Yersinia...	107	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Mobile and extrachromosomal element functions	Transposon functions

IDP04042 (show subtarget assignments)	1	cloned	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP04046 (show subtarget assignments)	1	cloned	YPCD1.78c	16082765	tap	repA translation protein [Yersinia pesti...	24	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04047 (show subtarget assignments)	1	cloned	YPCD1.92	5832507	YPCD1.92	hypothetical protein YPCD1.92 [Yersinia ...	109	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04052 (show subtarget assignments)	1	cloned	CPF_0049	110799596		putative lipoprotein [Clostridium perfri...	167	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04053 (show subtarget assignments)	1	cloned	CPF_2307	110801393	spoIIAA	anti-sigma F factor antagonist [Clostrid...	111	conserved gene; putative drug target function;	Phase 4: April 2009	1TH8	45%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04055 (show subtarget assignments)	1	cloned	STM0301_1_836	16763684	safC	putative fimbrial usher [Salmonella typh...	836	Salmonella essential protein	Phase 4: April 2009	3RFZ	37%	Salmonella enterica

IDP04061 (show subtarget assignments)	1	cloned	YPCD1.07	5832430	YPCD1.07	hypothetical protein YPCD1.07 [Yersinia ...	98	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04063 (show subtarget assignments)	1	cloned	CPF_0514	110800714		putative lipoprotein [Clostridium perfri...	176	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04065 (show subtarget assignments)	1	cloned	CPF_2985	110800289	yyaC	putative sporulation protein YyaC [Clost...	196	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04070 (show subtarget assignments)	1	cloned	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP04071 (show subtarget assignments)	1	cloned	BAS0129	49183163		50S ribosomal protein L15 [Bacillus anth...	146	Proposed to be essential proteins	Phase 4: April 2009	1VSA	51.4%	Bacillus anthracis

IDP04074 (show subtarget assignments)	1	cloned	BAS4469	49187464		50S ribosomal protein L20 [Bacillus anth...	118	Proposed to be essential proteins	Phase 4: April 2009	1VS6	55.1%	Bacillus anthracis

IDP04080 (show subtarget assignments)	1	cloned	BAS0123	49183157		30S ribosomal protein S14 [Bacillus anth...	61	Proposed to be essential proteins	Phase 4: April 2009	1FJG	73.8%	Bacillus anthracis

IDP04082 (show subtarget assignments)	1	cloned	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04083 (show subtarget assignments)	1	cloned	YPO1631	218928767	pepT	peptidase T [Yersinia pestis CO92]	411	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FNO	76.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04084 (show subtarget assignments)	1	cloned	VC2561	15642556		uroporphyrin-III C-methyltransferase [Vi...	299	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1PJQ	50.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04087 (show subtarget assignments)	1	cloned	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04091 (show subtarget assignments)	1	cloned	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04092 (show subtarget assignments)	1	cloned	CPF_1925	110801017	spoVS	stage V sporulation protein S [Clostridi...	86	conserved gene; putative drug target function;	Phase 4: April 2009	2EH1	57%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04097 (show subtarget assignments)	1	cloned	CPF_2217	110801384	yunB	sporulation protein YunB [Clostridium pe...	229	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04098 (show subtarget assignments)	1	cloned	YPCD1.50	5832470	YPCD1.50	hypothetical protein YPCD1.50 [Yersinia ...	32	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04100 (show subtarget assignments)	1	cloned	YPCD1.45	16082733	yscS	needle complex export protein [Yersinia ...	88	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04102 (show subtarget assignments)	1	cloned	YPO2227	218929324	pyrF	orotidine 5'-phosphate decarboxylase [Ye...	245	conserved gene; putative drug target function;	Phase 4: April 2009	1EIX	72.2%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP04103 (show subtarget assignments)	1	cloned	YPO2280	218929372		putative phage-related secreted protein ...	414	putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04106 (show subtarget assignments)	1	cloned	BAS0124	49183158		30S ribosomal protein S8 [Bacillus anthr...	132	Proposed to be essential proteins	Phase 4: April 2009	1SEI	85.6%	Bacillus anthracis

IDP04111 (show subtarget assignments)	1	cloned	YPO2524	115348222	menC	putative O-succinylbenzoate-CoA synthase...	323	conserved gene; putative drug target function;	Phase 4: April 2009	3GC2	66.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04112 (show subtarget assignments)	1	cloned	YPO2626	115348318	nagA	putative N-acetylglucosamine-6-phosphate...	381	drug target; putative drug target function;	Phase 4: April 2009	1YMY	75.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP04118 (show subtarget assignments)	1	cloned	YPCD1.22c	5832443	YPCD1.22c	hypothetical protein YPCD1.22c [Yersinia...	129	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04121 (show subtarget assignments)	1	cloned	YPO2725	115348408		conserved hypothetical protein [Yersinia...	921	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	12.6%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04125 (show subtarget assignments)	1	cloned	YPO2847	115348521	yegM	putitive HlyD family secretion protein [...	444	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	21.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04126 (show subtarget assignments)	1	cloned	YPO2871	115348542	guaB	inosine-5'-monophosphate dehydrogenase [...	487	conserved gene; putative drug target function;	Phase 4: April 2009	1ZFJ	56.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04130 (show subtarget assignments)	1	cloned	YPO2938	115348602		conserved hypothetical protein [Yersinia...	500	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04131 (show subtarget assignments)	1	cloned	YPO2947	115348609		conserved hypothetical protein [Yersinia...	626	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04132 (show subtarget assignments)	1	cloned	YPO2997	218930046		putative two-component system sensor kin...	449	putative drug target function;	Phase 4: April 2009	3JZ3	15.4%	Yersinia pestis	Regulatory functions	Other

IDP04133 (show subtarget assignments)	1	cloned	CPF_1195	110798868	hpkA	sensor histidine kinase [Clostridium per...	287	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	25.8%	Clostridium perfringens	Regulatory functions	Other

IDP04135 (show subtarget assignments)	1	cloned	BAS4470	49187465		50S ribosomal protein L35 [Bacillus anth...	66	Proposed to be essential proteins	Phase 4: April 2009	1VS6	48.5%	Bacillus anthracis

IDP04140 (show subtarget assignments)	1	cloned	YPO3116	115348760	ascD	cdp-6-deoxy-delta-3,4-glucoseen reductas...	329	virulence factor; putative drug target function;	Phase 4: April 2009	1KRH	26.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04151 (show subtarget assignments)	1	cloned	YPO3864	218930867	nfrC	UDP-N-acetylglucosamine 2-epimerase [Yer...	376	drug target; putative drug target function;	Phase 4: April 2009	1F6D	78.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04152 (show subtarget assignments)	1	cloned	YPO3919	218930919		HlyD family secretion protein [Yersinia ...	442	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04153 (show subtarget assignments)	1	cloned	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04154 (show subtarget assignments)	1	cloned	YPO4017	218931008	hutU	urocanate hydratase [Yersinia pestis CO9...	563	conserved gene; putative drug target function;	Phase 4: April 2009	1UWL	86.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04155 (show subtarget assignments)	1	cloned	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04159 (show subtarget assignments)	1	cloned	VC1134	15641147		histidinol-phosphate aminotransferase [V...	346	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1FG3	59.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP04161 (show subtarget assignments)	1	cloned	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP04164 (show subtarget assignments)	1	cloned	VC1445	15641456		sensor histidine kinase/response regulat...	572	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.5%	Vibrio cholerae	Regulatory functions	Other

IDP04166 (show subtarget assignments)	1	cloned	VC1653	15641658		sensory box sensor histidine kinase/resp...	1146	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	6.6%	Vibrio cholerae	Regulatory functions	Other

IDP04167 (show subtarget assignments)	1	cloned	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04170 (show subtarget assignments)	1	cloned	VC2183	15642182		ribose-phosphate pyrophosphokinase [Vibr...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3DAH	63.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04171 (show subtarget assignments)	1	cloned	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04179 (show subtarget assignments)	1	cloned	VCA0068	15600839		methyl-accepting chemotaxis protein [Vib...	547	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1QU7	14.4%	Vibrio cholerae	Cellular processes	Chemotaxis and motility

IDP04182 (show subtarget assignments)	1	cloned	VCA0238	15601006		sensor histidine kinase [Vibrio cholerae...	549	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	12%	Vibrio cholerae	Regulatory functions	Other

IDP04186 (show subtarget assignments)	1	cloned	VCA0709	9658128		sensor protein TorS [Vibrio cholerae O1 ...	1020	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3I9Y	17.1%	Vibrio cholerae	Regulatory functions	Other

IDP04190 (show subtarget assignments)	1	cloned	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04192 (show subtarget assignments)	1	cloned	CPF_0671	110799768		phosphoribosylformylglycinamidine syntha...	1266	conserved gene; putative drug target function;	Phase 4: April 2009	3AC6	15.2%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04193 (show subtarget assignments)	1	cloned	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04194 (show subtarget assignments)	1	cloned	CPF_2444	110799147	yyaC	putative sporulation protein YyaC [Clost...	176	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04195 (show subtarget assignments)	1	cloned	CPF_2448	110798809	spoIID	stage II sporulation protein D [Clostrid...	340	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04196 (show subtarget assignments)	1	cloned	CPF_2502	110800817		putative lipoprotein [Clostridium perfri...	507	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04199 (show subtarget assignments)	1	cloned	CPF_2557	110800712	guaA	bifunctional GMP synthase/glutamine amid...	509	conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	52.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04202 (show subtarget assignments)	1	cloned	CPF_2277	110798838		putative stage IV sporulation protein [C...	378	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04206 (show subtarget assignments)	1	cloned	CPF_2812	110799133	prsA	ribose-phosphate pyrophosphokinase [Clos...	319	conserved gene; putative drug target function;	Phase 4: April 2009	1DKR	63%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04212 (show subtarget assignments)	1	cloned	STM0646_1_343	16764023	holA	DNA polymerase III subunit delta [Salmon...	343	Salmonella essential protein	Phase 4: April 2009	1JQJ	89.8%	Salmonella enterica

IDP04213 (show subtarget assignments)	1	cloned	STM1003_1_478	16764363		putative transcriptional regulator [Salm...	478	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04215 (show subtarget assignments)	1	cloned	STM1574_1_495	16764918	smvA	methyl viologen resistance [Salmonella t...	495	Salmonella essential protein	Phase 4: April 2009	2GFP	17%	Salmonella enterica

IDP04216 (show subtarget assignments)	1	cloned	STM1894_1_336	16765236	ruvB	Holliday junction DNA helicase B [Salmon...	336	Salmonella essential protein	Phase 4: April 2009	1HQC	53%	Salmonella enterica

IDP04217 (show subtarget assignments)	1	cloned	STM2619_1_203	16765939		hypothetical protein STM2619 [Salmonella...	203	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04219 (show subtarget assignments)	1	cloned	STM3148_1_392	16766448	hybB	putative hydrogenase 2 b cytochrome subu...	392	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04225 (show subtarget assignments)	8	cloned	CAC05803	12329072	ipaB	IpaB, secreted by the Mxi-Spa secretion ...	580	Shigella effector protein	Community Requests	3GZ2	9.8%	Shigella flexneri

IDP04226 (show subtarget assignments)	1	cloned	CPF_0171	110799571	luxS	S-ribosylhomocysteinase [Clostridium per...	151	conserved gene; putative drug target function;	Phase 4: April 2009	1J6W	51%	Clostridium perfringens	Cellular processes	Other

IDP02814
(show subtarget assignments)

1

cloned

FTT0709

56707828

eno

enolase (2-phosphoglycerate dehydratase)...

456

Conserved; Drug target functions

Phase 3: June 2008

1IYX

60.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02817
(show subtarget assignments)

1

cloned

lmo2185

16804224

hypothetical protein lmo2185 [Listeria m...

569

Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...

Phase 3: June 2008

2O6P

8.4%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP02822
(show subtarget assignments)

1

cloned

GBAA4819

47778330

infC

translation initiation factor IF-3 [Baci...

186

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TIG

40.9%

Bacillus anthracis

Protein synthesis

Translation factors

IDP02827
(show subtarget assignments)

1

cloned

FTT1508c

56708546

relA

GTP pyrophosphokinase [Francisella tular...

647

Drug Target

Phase 3: June 2008

1VJ7

20.1%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02828
(show subtarget assignments)

1

cloned

GBAA4243

47529536

hypothetical protein GBAA4243 [Bacillus ...

205

Drug target motif;

Phase 3: June 2008

Bacillus anthracis

N/A

IDP02829
(show subtarget assignments)

1

cloned

GBAA4382

47529677

bfmbB

branched-chain alpha-keto acid dehydroge...

439

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.4%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02833
(show subtarget assignments)

1

cloned

GBAA4561

47529857

aroE

shikimate 5-dehydrogenase [Bacillus anth...

308

Conserved; Drug target functions

Phase 3: June 2008

2EGG

49.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP04003
(show subtarget assignments)

1

cloned

BAS0126

49183160

50S ribosomal protein L18 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1OVY

75.8%

Bacillus anthracis

IDP04004
(show subtarget assignments)

1

cloned

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP04006
(show subtarget assignments)

1

cloned

CPF_1351

110800739

putative lipoprotein [Clostridium perfri...

264

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04008
(show subtarget assignments)

1

cloned

YPO0906

218928079

gcsH

glycine cleavage system protein H [Yersi...

128

conserved gene; putative drug target function;

Phase 4: April 2009

3A7A

75%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04009
(show subtarget assignments)

1

cloned

VC2277

15642275

xanthine-guanine phosphoribosyltransfera...

154

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A95

68.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP04010
(show subtarget assignments)

1

cloned

CPF_2393

110798628

minD

septum site-determining protein MinD [Cl...

265

conserved gene; putative drug target function;

Phase 4: April 2009

3Q9L

43.4%

Clostridium perfringens

Cellular processes

Cell division

IDP04011
(show subtarget assignments)

1

cloned

CPF_2475

110800353

stage II sporulation protein R [Clostrid...

209

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04012
(show subtarget assignments)

1

cloned

CPF_2355

110800506

virJ

sensor histidine kinase [Clostridium per...

482

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

15.4%

Clostridium perfringens

Cellular processes

Pathogenesis

IDP04013
(show subtarget assignments)

1

cloned

STM2913_1_498

16766219

putative permease [Salmonella typhimuriu...

498

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04017
(show subtarget assignments)

1

cloned

CPF_1035

110799411

putative lipoprotein [Clostridium perfri...

309

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04018
(show subtarget assignments)

1

cloned

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04019
(show subtarget assignments)

1

cloned

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04020
(show subtarget assignments)

1

cloned

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04022
(show subtarget assignments)

1

cloned

BAS0095

49183129

preprotein translocase subunit SecE [Bac...

59

Proposed to be essential proteins

Phase 4: April 2009

3DIN

33.9%

Bacillus anthracis

IDP04023
(show subtarget assignments)

1

cloned

YPO0511a

115346321

hypothetical protein [Yersinia pestis CO...

121

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04024
(show subtarget assignments)

1

cloned

BAS5319

49188303

DNA-binding response regulator YycF [Bac...

235

Proposed to be essential proteins

Phase 4: April 2009

2OQR

47.7%

Bacillus anthracis

IDP04027
(show subtarget assignments)

1

cloned

BAS4637

49187628

leucyl-tRNA synthetase [Bacillus anthrac...

802

Proposed to be essential proteins

Phase 4: April 2009

1H3N

45.9%

Bacillus anthracis

IDP04030
(show subtarget assignments)

1

cloned

YPO2532

115348229

hypothetical protein [Yersinia pestis CO...

70

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04031
(show subtarget assignments)

1

cloned

CBU_A0011

29648123

hypothetical protein CBUA0011 [Coxiella ...

56

drug target;

Phase 4: April 2009

Coxiella burnetii

Hypothetical proteins

Domain

IDP04032
(show subtarget assignments)

1

cloned

CPF_2081

110798910

stage III sporulation protein AG [Clostr...

201

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04036
(show subtarget assignments)

1

cloned

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04039
(show subtarget assignments)

1

cloned

CPF_2446

110800060

spoIIID

stage III sporulation protein D [Clostri...

83

conserved gene; putative drug target function;

Phase 4: April 2009

2L0K

60.2%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04040
(show subtarget assignments)

1

cloned

CPF_1068

110800949

cotJC

spore coat protein CotJC [Clostridium pe...

188

conserved gene; putative drug target function;

Phase 4: April 2009

1JKU

34.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04041
(show subtarget assignments)

1

cloned

YPCD1.16c

5832438

YPCD1.16c

hypothetical protein YPCD1.16c [Yersinia...

107

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Mobile and extrachromosomal element functions

Transposon functions

IDP04042
(show subtarget assignments)

1

cloned

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP04046
(show subtarget assignments)

1

cloned

YPCD1.78c

16082765

tap

repA translation protein [Yersinia pesti...

24

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04047
(show subtarget assignments)

1

cloned

YPCD1.92

5832507

YPCD1.92

hypothetical protein YPCD1.92 [Yersinia ...

109

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04052
(show subtarget assignments)

1

cloned

CPF_0049

110799596

putative lipoprotein [Clostridium perfri...

167

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04053
(show subtarget assignments)

1

cloned

CPF_2307

110801393

spoIIAA

anti-sigma F factor antagonist [Clostrid...

111

conserved gene; putative drug target function;

Phase 4: April 2009

1TH8

45%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04055
(show subtarget assignments)

1

cloned

STM0301_1_836

16763684

safC

putative fimbrial usher [Salmonella typh...

836

Salmonella essential protein

Phase 4: April 2009

3RFZ

37%

Salmonella enterica

IDP04061
(show subtarget assignments)

1

cloned

YPCD1.07

5832430

YPCD1.07

hypothetical protein YPCD1.07 [Yersinia ...

98

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04063
(show subtarget assignments)

1

cloned

CPF_0514

110800714

putative lipoprotein [Clostridium perfri...

176

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04065
(show subtarget assignments)

1

cloned

CPF_2985

110800289

yyaC

putative sporulation protein YyaC [Clost...

196

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04070
(show subtarget assignments)

1

cloned

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP04071
(show subtarget assignments)

1

cloned

BAS0129

49183163

50S ribosomal protein L15 [Bacillus anth...

146

Proposed to be essential proteins

Phase 4: April 2009

1VSA

51.4%

Bacillus anthracis

IDP04074
(show subtarget assignments)

1

cloned

BAS4469

49187464

50S ribosomal protein L20 [Bacillus anth...

118

Proposed to be essential proteins

Phase 4: April 2009

1VS6

55.1%

Bacillus anthracis

IDP04080
(show subtarget assignments)

1

cloned

BAS0123

49183157

30S ribosomal protein S14 [Bacillus anth...

61

Proposed to be essential proteins

Phase 4: April 2009

1FJG

73.8%

Bacillus anthracis

IDP04082
(show subtarget assignments)

1

cloned

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04083
(show subtarget assignments)

1

cloned

YPO1631

218928767

pepT

peptidase T [Yersinia pestis CO92]

411

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FNO

76.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04084
(show subtarget assignments)

1

cloned

VC2561

15642556

uroporphyrin-III C-methyltransferase [Vi...

299

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1PJQ

50.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04087
(show subtarget assignments)

1

cloned

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04091
(show subtarget assignments)

1

cloned

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04092
(show subtarget assignments)

1

cloned

CPF_1925

110801017

spoVS

stage V sporulation protein S [Clostridi...

86

conserved gene; putative drug target function;

Phase 4: April 2009

2EH1

57%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04097
(show subtarget assignments)

1

cloned

CPF_2217

110801384

yunB

sporulation protein YunB [Clostridium pe...

229

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04098
(show subtarget assignments)

1

cloned

YPCD1.50

5832470

YPCD1.50

hypothetical protein YPCD1.50 [Yersinia ...

32

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04100
(show subtarget assignments)

1

cloned

YPCD1.45

16082733

yscS

needle complex export protein [Yersinia ...

88

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04102
(show subtarget assignments)

1

cloned

YPO2227

218929324

pyrF

orotidine 5'-phosphate decarboxylase [Ye...

245

conserved gene; putative drug target function;

Phase 4: April 2009

1EIX

72.2%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP04103
(show subtarget assignments)

1

cloned

YPO2280

218929372

putative phage-related secreted protein ...

414

putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04106
(show subtarget assignments)

1

cloned

BAS0124

49183158

30S ribosomal protein S8 [Bacillus anthr...

132

Proposed to be essential proteins

Phase 4: April 2009

1SEI

85.6%

Bacillus anthracis

IDP04111
(show subtarget assignments)

1

cloned

YPO2524

115348222

menC

putative O-succinylbenzoate-CoA synthase...

323

conserved gene; putative drug target function;

Phase 4: April 2009

3GC2

66.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04112
(show subtarget assignments)

1

cloned

YPO2626

115348318

nagA

putative N-acetylglucosamine-6-phosphate...

381

drug target; putative drug target function;

Phase 4: April 2009

1YMY

75.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP04118
(show subtarget assignments)

1

cloned

YPCD1.22c

5832443

YPCD1.22c

hypothetical protein YPCD1.22c [Yersinia...

129

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04121
(show subtarget assignments)

1

cloned

YPO2725

115348408

conserved hypothetical protein [Yersinia...

921

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

12.6%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04125
(show subtarget assignments)

1

cloned

YPO2847

115348521

yegM

putitive HlyD family secretion protein [...

444

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

21.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04126
(show subtarget assignments)

1

cloned

YPO2871

115348542

guaB

inosine-5'-monophosphate dehydrogenase [...

487

conserved gene; putative drug target function;

Phase 4: April 2009

1ZFJ

56.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04130
(show subtarget assignments)

1

cloned

YPO2938

115348602

conserved hypothetical protein [Yersinia...

500

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04131
(show subtarget assignments)

1

cloned

YPO2947

115348609

conserved hypothetical protein [Yersinia...

626

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04132
(show subtarget assignments)

1

cloned

YPO2997

218930046

putative two-component system sensor kin...

449

putative drug target function;

Phase 4: April 2009

3JZ3

15.4%

Yersinia pestis

Regulatory functions

Other

IDP04133
(show subtarget assignments)

1

cloned

CPF_1195

110798868

hpkA

sensor histidine kinase [Clostridium per...

287

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

25.8%

Clostridium perfringens

Regulatory functions

Other

IDP04135
(show subtarget assignments)

1

cloned

BAS4470

49187465

50S ribosomal protein L35 [Bacillus anth...

66

Proposed to be essential proteins

Phase 4: April 2009

1VS6

48.5%

Bacillus anthracis

IDP04140
(show subtarget assignments)

1

cloned

YPO3116

115348760

ascD

cdp-6-deoxy-delta-3,4-glucoseen reductas...

329

virulence factor; putative drug target function;

Phase 4: April 2009

1KRH

26.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04151
(show subtarget assignments)

1

cloned

YPO3864

218930867

nfrC

UDP-N-acetylglucosamine 2-epimerase [Yer...

376

drug target; putative drug target function;

Phase 4: April 2009

1F6D

78.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04152
(show subtarget assignments)

1

cloned

YPO3919

218930919

HlyD family secretion protein [Yersinia ...

442

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04153
(show subtarget assignments)

1

cloned

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04154
(show subtarget assignments)

1

cloned

YPO4017

218931008

hutU

urocanate hydratase [Yersinia pestis CO9...

563

conserved gene; putative drug target function;

Phase 4: April 2009

1UWL

86.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04155
(show subtarget assignments)

1

cloned

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04159
(show subtarget assignments)

1

cloned

VC1134

15641147

histidinol-phosphate aminotransferase [V...

346

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1FG3

59.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP04161
(show subtarget assignments)

1

cloned

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP04164
(show subtarget assignments)

1

cloned

VC1445

15641456

sensor histidine kinase/response regulat...

572

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.5%

Vibrio cholerae

Regulatory functions

Other

IDP04166
(show subtarget assignments)

1

cloned

VC1653

15641658

sensory box sensor histidine kinase/resp...

1146

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

6.6%

Vibrio cholerae

Regulatory functions

Other

IDP04167
(show subtarget assignments)

1

cloned

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04170
(show subtarget assignments)

1

cloned

VC2183

15642182

ribose-phosphate pyrophosphokinase [Vibr...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3DAH

63.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04171
(show subtarget assignments)

1

cloned

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04179
(show subtarget assignments)

1

cloned

VCA0068

15600839

methyl-accepting chemotaxis protein [Vib...

547

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1QU7

14.4%

Vibrio cholerae

Cellular processes

Chemotaxis and motility

IDP04182
(show subtarget assignments)

1

cloned

VCA0238

15601006

sensor histidine kinase [Vibrio cholerae...

549

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

12%

Vibrio cholerae

Regulatory functions

Other

IDP04186
(show subtarget assignments)

1

cloned

VCA0709

9658128

sensor protein TorS [Vibrio cholerae O1 ...

1020

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3I9Y

17.1%

Vibrio cholerae

Regulatory functions

Other

IDP04190
(show subtarget assignments)

1

cloned

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04192
(show subtarget assignments)

1

cloned

CPF_0671

110799768

phosphoribosylformylglycinamidine syntha...

1266

conserved gene; putative drug target function;

Phase 4: April 2009

3AC6

15.2%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04193
(show subtarget assignments)

1

cloned

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04194
(show subtarget assignments)

1

cloned

CPF_2444

110799147

yyaC

putative sporulation protein YyaC [Clost...

176

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04195
(show subtarget assignments)

1

cloned

CPF_2448

110798809

spoIID

stage II sporulation protein D [Clostrid...

340

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04196
(show subtarget assignments)

1

cloned

CPF_2502

110800817

putative lipoprotein [Clostridium perfri...

507

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04199
(show subtarget assignments)

1

cloned

CPF_2557

110800712

guaA

bifunctional GMP synthase/glutamine amid...

509

conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

52.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04202
(show subtarget assignments)

1

cloned

CPF_2277

110798838

putative stage IV sporulation protein [C...

378

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04206
(show subtarget assignments)

1

cloned

CPF_2812

110799133

prsA

ribose-phosphate pyrophosphokinase [Clos...

319

conserved gene; putative drug target function;

Phase 4: April 2009

1DKR

63%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04212
(show subtarget assignments)

1

cloned

STM0646_1_343

16764023

holA

DNA polymerase III subunit delta [Salmon...

343

Salmonella essential protein

Phase 4: April 2009

1JQJ

89.8%

Salmonella enterica

IDP04213
(show subtarget assignments)

1

cloned

STM1003_1_478

16764363

putative transcriptional regulator [Salm...

478

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04215
(show subtarget assignments)

1

cloned

STM1574_1_495

16764918

smvA

methyl viologen resistance [Salmonella t...

495

Salmonella essential protein

Phase 4: April 2009

2GFP

17%

Salmonella enterica

IDP04216
(show subtarget assignments)

1

cloned

STM1894_1_336

16765236

ruvB

Holliday junction DNA helicase B [Salmon...

336

Salmonella essential protein

Phase 4: April 2009

1HQC

53%

Salmonella enterica

IDP04217
(show subtarget assignments)

1

cloned

STM2619_1_203

16765939

hypothetical protein STM2619 [Salmonella...

203

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04219
(show subtarget assignments)

1

cloned

STM3148_1_392

16766448

hybB

putative hydrogenase 2 b cytochrome subu...

392

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04225
(show subtarget assignments)

8

cloned

CAC05803

12329072

ipaB

IpaB, secreted by the Mxi-Spa secretion ...

580

Shigella effector protein

Community Requests

3GZ2

9.8%

Shigella flexneri

IDP04226
(show subtarget assignments)

1

cloned

CPF_0171

110799571

luxS

S-ribosylhomocysteinase [Clostridium per...

151

conserved gene; putative drug target function;

Phase 4: April 2009

1J6W

51%

Clostridium perfringens

Cellular processes

Other

Targets