Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01761 (show subtarget assignments)	1	cloned	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02439 (show subtarget assignments)	1	cloned	GBAA3892	47529180		serine protease [Bacillus anthracis str....	613	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2OXA	16.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02558 (show subtarget assignments)	1	cloned	GBAA4584	47529880	vpR	minor extracellular protease VpR [Bacill...	917	Drug target motif; Drug target functions	Phase 3: June 2008	3EIF	22.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02432 (show subtarget assignments)	1	soluble	GBAA3687	47528971		acetyl-CoA acetyltransferase [Bacillus a...	363	Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...	Phase 3: June 2008	4DD5	39.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP02574 (show subtarget assignments)	1	cloned	GBAA1995	47527292		protease, putative [Bacillus anthracis s...	386	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02746 (show subtarget assignments)	1	soluble	GBAA0157	47525415	glmM	phosphoglucosamine mutase [Bacillus anth...	448	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PDK	100%	Bacillus anthracis	Cell envelope	N/A

IDP02560 (show subtarget assignments)	1	cloned	GBAA0268	47777798	guaA	bifunctional GMP synthase/glutamine amid...	512	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPM	52.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01610 (show subtarget assignments)	1	in_pdb 3I1I	GBAA4983	47778350		homoserine O-acetyltransferase [Bacillus...	374	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I1I	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02534 (show subtarget assignments)	1	cloned	GBAA4614	47529912		Holliday junction resolvase-like protein...	137	Conserved;	Phase 3: June 2008	1VHX	70.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01752 (show subtarget assignments)	1	selected	GBAA5282	47778383	nprB	neutral protease B [Bacillus anthracis s...	547	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1KEI	31.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02535 (show subtarget assignments)	1	expressed	GBAA0088	47525343	cysE	serine O-acetyltransferase [Bacillus ant...	221	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GVD	36.2%	Bacillus anthracis	Amino acid biosynthesis	Serine family

IDP02537 (show subtarget assignments)	0	work_stopped	GBAA4558	47778307	nadD	nicotinic acid mononucleotide adenylyltr...	171	Conserved; Drug target functions	Phase 3: June 2008	2QTM	99.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP02533 (show subtarget assignments)	1	expressed	GBAA4184	47529480	pdhA	pyruvate dehydrogenase complex E1 compon...	371	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	80.9%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP02758 (show subtarget assignments)	1	cloned	GBAA_pXO2_0073	47566739		signal peptidase i, (pxo2-59) [Bacillus ...	183	Drug target motif;	Phase 3: June 2008	1B12	8.7%	Bacillus anthracis	N/A	N/A

IDP01736 (show subtarget assignments)	1	expressed	GBAA5503	47530821		sensor histidine kinase [Bacillus anthra...	476	Conserved; Drug target functions	Phase 3: June 2008	2C2A	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02549 (show subtarget assignments)	1	soluble	GBAA0547	47525820		RNA methyltransferase [Bacillus anthraci...	162	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L8U	51.2%	Bacillus anthracis	Protein synthesis	tRNA and rRNA base modification

IDP02525 (show subtarget assignments)	1	crystallized	GBAA4351	47529646	argF	ornithine carbamoyltransferase [Bacillus...	316	Conserved; Drug target functions	Phase 3: June 2008	1A1S	55.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02528 (show subtarget assignments)	1	soluble	GBAA4405	47529699	folD	methylenetetrahydrofolate dehydrogenase/...	286	Essential; Drug target functions	Phase 3: June 2008	3P2O	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02523 (show subtarget assignments)	1	cloned	GBAA4297	47529591	dacF	D-alanyl-D-alanine carboxypeptidase [Bac...	396	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IT9	32.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01794 (show subtarget assignments)	1	purified	GBAA1026	47526305	glpK	glycerol kinase [Bacillus anthracis str....	496	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3G25	75%	Bacillus anthracis	Energy metabolism	Other

IDP02524 (show subtarget assignments)	1	purified	GBAA1852	47527143	ilvC-2	ketol-acid reductoisomerase [Bacillus an...	335	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	56.1%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02763 (show subtarget assignments)	1	cloned	GBAA2547	47527836		acyl-CoA dehydrogenase [Bacillus anthrac...	381	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VIG	50.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP01726 (show subtarget assignments)	1	cloned	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01606 (show subtarget assignments)	1	cloned	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP02531 (show subtarget assignments)	1	in_pdb 3LAC	GBAA3090	50196941	pcP	pyrrolidone-carboxylate peptidase [Bacil...	215	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LAC	99.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02767 (show subtarget assignments)	1	cloned	GBAA4750	47530050		D-alanyl-D-alanine carboxypeptidase fami...	259	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01723 (show subtarget assignments)	1	in_pdb 3KAX	GBAA5138	47530443		aminotransferase, classes I and II [Baci...	383	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3KAX	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01724 (show subtarget assignments)	1	expressed	GBAA5248	47530553		acetyl-CoA acetyltransferase [Bacillus a...	390	Conserved; Essential; Drug target functions	Phase 3: June 2008	2C7Y	47.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP02575 (show subtarget assignments)	1	cloned	GBAA5123	47778366	glgB	glycogen branching enzyme [Bacillus anth...	645	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K1D	43.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02312 (show subtarget assignments)	1	expressed	GBAA2190	47778017		FtsK/SpoIIIE family protein [Bacillus an...	1342	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IUT	7.4%	Bacillus anthracis	Cellular processes	Cell division

IDP01725 (show subtarget assignments)	0	work_stopped	GBAA2534	47527824		acetyltransferase [Bacillus anthracis st...	168	CONSERVED	Phase 3: June 2008	3FBU	100%	Bacillus anthracis	N/A	N/A

IDP02532 (show subtarget assignments)	1	cloned	GBAA1879	47527172		M23/37 family peptidase [Bacillus anthra...	262	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01712 (show subtarget assignments)	1	in_pdb 3EFE	GBAA2657	47551781		thiJ/pfpI family protein [Bacillus anthr...	210	CONSERVED	Phase 3: June 2008	3EFE	100%	Bacillus anthracis	N/A	N/A

IDP01540 (show subtarget assignments)	1	in_pdb 3EC6	GBAA0418	47525694		general stress protein 26 [Bacillus anth...	138	CONSERVED	Phase 3: June 2008	3EC6	100%	Bacillus anthracis

IDP01711 (show subtarget assignments)	1	expressed	GBAA5380	47530690	clpP	ATP-dependent Clp protease proteolytic s...	193	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TT7	89.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01710 (show subtarget assignments)	1	purified	GBAA0371	47525642		glycosyl hydrolase family protein [Bacil...	554	Conserved; Drug target functions	Phase 3: June 2008	2ZE0	67%	Bacillus anthracis	Energy metabolism	Sugars

IDP00002 (show subtarget assignments)	1	expressed	GBAA_pXO1_0079	47566400	-	surface layer protein, (pxo1-54)	404	Drug Target Homolog	Phase 1: October 2007	3PYW	14.4%	Bacillus anthracis

IDP02320 (show subtarget assignments)	1	purified	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01704 (show subtarget assignments)	1	expressed	GBAA5215	47530521		aminotransferase, class V [Bacillus anth...	406	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T3I	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01640 (show subtarget assignments)	1	purified	GBAA4357	47529653		short chain dehydrogenase/reductase fami...	264	Conserved; Essential;	Phase 3: June 2008	3P19	33.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01702 (show subtarget assignments)	1	soluble	GBAA0261	47525520	gcP	O-sialoglycoprotein endopeptidase [Bacil...	338	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IVN	35.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02325 (show subtarget assignments)	1	in_pdb 3IMF	GBAA4204	47778260		short chain dehydrogenase [Bacillus anth...	254	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3IMF	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01639 (show subtarget assignments)	1	cloned	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01719 (show subtarget assignments)	1	purified	GBAA5560	47530880		ribose-5-phosphate isomerase B [Bacillus...	147	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HE8	55.1%	Bacillus anthracis	Energy metabolism	Sugars

IDP01695 (show subtarget assignments)	1	expressed	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	Phase 3: June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02329 (show subtarget assignments)	1	in_pdb 3KQF	GBAA2551	47527840		enoyl-CoA hydratase [Bacillus anthracis ...	262	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3KQF	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04136 (show subtarget assignments)	1	purified	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02427 (show subtarget assignments)	1	purified	GBAA3553	47528837	pepF-2	oligoendopeptidase F [Bacillus anthracis...	595	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QR4	37.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01683 (show subtarget assignments)	1	expressed	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02335 (show subtarget assignments)	1	expressed	GBAA2583	47527873		hypothetical protein GBAA2583 [Bacillus ...	563	Drug target motif; Involved in sporulation;	Phase 3: June 2008	3SKS	26.3%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01682 (show subtarget assignments)	1	cloned	GBAA5104	47530405		D-alanyl-D-alanine carboxypeptidase fami...	286	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04109 (show subtarget assignments)	1	crystallized	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02518 (show subtarget assignments)	1	purified	GBAA5557	47530877	upp	uracil phosphoribosyltransferase [Bacill...	209	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1I5E	84.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02338 (show subtarget assignments)	1	cloned	GBAA1456	47526731		sensor histidine kinase [Bacillus anthra...	351	Conserved; Drug target functions	Phase 3: June 2008	3EHH	14.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01681 (show subtarget assignments)	1	cloned	GBAA4795	47530092		hypothetical protein GBAA4795 [Bacillus ...	572	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3AU2	37.1%	Bacillus anthracis	Unknown function	General

IDP02519 (show subtarget assignments)	1	cloned	GBAA1494	47526768	resA	thiol-disulfide oxidoreductase [Bacillus...	173	Conserved; Drug target functions	Phase 3: June 2008	1ST9	41.6%	Bacillus anthracis	Energy metabolism	Electron transport

IDP01675 (show subtarget assignments)	1	purified	GBAA5217	47530523		ABC transporter ATP-binding protein [Bac...	261	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2D2E	57.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02346 (show subtarget assignments)	1	cloned	GBAA2832	47528125	dapA-1	dihydrodipicolinate synthase [Bacillus a...	298	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NA8	34.2%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01673 (show subtarget assignments)	1	soluble	GBAA5206	47530513		M23/37 family peptidase [Bacillus anthra...	327	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	3SLU	25.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01668 (show subtarget assignments)	1	soluble	GBAA0060	47525314		hypothetical protein GBAA0060 [Bacillus ...	160	Essential;	Phase 3: June 2008	2K4K	29.4%	Bacillus anthracis	Unknown function	General

IDP01670 (show subtarget assignments)	1	cloned	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	Phase 3: June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02795 (show subtarget assignments)	1	in_pdb 3LNO	GBAA5281	47530589		hypothetical protein GBAA5281 [Bacillus ...	105	Conserved; Involved in sporulation;	Phase 3: June 2008	3LNO	100%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02513 (show subtarget assignments)	1	soluble	GBAA0258	47525517		hypothetical protein GBAA0258 [Bacillus ...	157	Conserved;	Phase 3: June 2008	1FL9	30.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01672 (show subtarget assignments)	1	soluble	GBAA5133	47530438		hypothetical protein GBAA5133 [Bacillus ...	396	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1DJU	48.2%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01677 (show subtarget assignments)	1	soluble	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP01663 (show subtarget assignments)	1	purified	GBAA4696	47529995	hemC	porphobilinogen deaminase [Bacillus anth...	309	Conserved; Drug target functions	Phase 3: June 2008	1AH5	46.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01666 (show subtarget assignments)	1	soluble	GBAA4704	47530003	clpX	ATP-dependent protease ATP-binding subun...	419	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HTE	52.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02490 (show subtarget assignments)	1	purified	GBAA3974	47529264	sucC	succinyl-CoA synthetase subunit beta [Ba...	386	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CQI	54.7%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04076 (show subtarget assignments)	1	expressed	GBAA2213	47527506		sensor histidine kinase [Bacillus anthra...	452	putative drug target function;	Phase 4: April 2009	2C2A	18.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP02802 (show subtarget assignments)	1	cloned	GBAA3471	47528757		short chain dehydrogenase/reductase fami...	234	Conserved; Essential;	Phase 3: June 2008	1SNY	26.8%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01661 (show subtarget assignments)	1	soluble	GBAA4609	47529906		U32 family peptidase [Bacillus anthracis...	426	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01678 (show subtarget assignments)	1	cloned	GBAA5591	47530913		cardiolipin synthetase domain-containing...	397	Drug target motif; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01626 (show subtarget assignments)	1	cloned	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02245 (show subtarget assignments)	1	cloned	GBAA1751	47527043	asnO-2	asparagine synthetase, glutamine-hydroly...	607	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CT9	25.9%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01605 (show subtarget assignments)	1	soluble	GBAA4560	47529856		hypothetical protein GBAA4560 [Bacillus ...	97	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1RQ8	67%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02517 (show subtarget assignments)	1	soluble	GBAA2315	47527614		S-layer protein, putative [Bacillus anth...	383	Drug target motif; Drug target functions	Phase 3: June 2008	3PYW	15.9%	Bacillus anthracis	Cell envelope	Surface structures

IDP02576 (show subtarget assignments)	1	purified	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02374 (show subtarget assignments)	1	purified	GBAA3116	47528407	ppsA	phosphoenolpyruvate synthase [Bacillus a...	868	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OLS	15.7%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01917 (show subtarget assignments)	1	soluble	GBAA1429	47526701	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	239	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VZW	36.5%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02734 (show subtarget assignments)	1	cloned	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP01795 (show subtarget assignments)	1	expressed	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04028 (show subtarget assignments)	1	soluble	BAS0109	49183143		30S ribosomal protein S10 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1P6G	61.8%	Bacillus anthracis

IDP04057 (show subtarget assignments)	1	purified	BAS0125	49183159		50S ribosomal protein L6 [Bacillus anthr...	179	Proposed to be essential proteins	Phase 4: April 2009	1C04	74.9%	Bacillus anthracis

IDP05023 (show subtarget assignments)	1	expressed	BAS2353	49185362	-	hemolysin II, C-terminal [Bacillus anthr...	240	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3ANZ	27.9%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP05024 (show subtarget assignments)	1	soluble	BAS4675	49187666	-	ABC transporter, substrate-binding prote...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	20.6%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP04027 (show subtarget assignments)	1	cloned	BAS4637	49187628		leucyl-tRNA synthetase [Bacillus anthrac...	802	Proposed to be essential proteins	Phase 4: April 2009	1H3N	45.9%	Bacillus anthracis

IDP05025 (show subtarget assignments)	1	cloned	BAS4742	49187733	-	hypothetical protein BAS4742 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP04005 (show subtarget assignments)	1	purified	BAS4355	49187350		valyl-tRNA synthetase [Bacillus anthraci...	881	Proposed to be essential proteins	Phase 4: April 2009	1GAX	42.6%	Bacillus anthracis

IDP04003 (show subtarget assignments)	1	cloned	BAS0126	49183160		50S ribosomal protein L18 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1OVY	75.8%	Bacillus anthracis

IDP05142 (show subtarget assignments)	1	cloned	BAS2027	49185038	-	isoleucyl-tRNA synthetase [Bacillus anth...	1033	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ILE	38.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05141 (show subtarget assignments)	1	cloned	BAS2021	49185032	argS	arginyl-tRNA synthetase [Bacillus anthra...	562	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1BS2	36.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05140 (show subtarget assignments)	1	soluble	BAS0382	49183410	-	prolyl-tRNA synthetase [Bacillus anthrac...	508	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H4Q	48.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05139 (show subtarget assignments)	1	soluble	BAS0353	49183381	-	amino acid ABC transporter, solute bindi...	264	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQL	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05452 (show subtarget assignments)	1	cloned	BAS5207	49188193	-	collagen adhesion protein, C-terminal [B...	882	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3KPT	12.6%	Bacillus anthracis	Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05421 (show subtarget assignments)	1	soluble	BAS1418	49184435	-	hypothetical protein BAS1418 [Bacillus a...	237	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05453 (show subtarget assignments)	1	purified	BAS5213	49188199	-	arginyl-tRNA synthetase [Bacillus anthra...	556	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.8%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP04416 (show subtarget assignments)	1	purified	BAS4049	49187047		ribonuclease Z [Bacillus anthracis str. ...	307	Proposed to be essential proteins	Phase 4: April 2009	1Y44	61.2%	Bacillus anthracis

IDP04064 (show subtarget assignments)	1	expressed	BAS0127	49183161		30S ribosomal protein S5 [Bacillus anthr...	166	Proposed to be essential proteins	Phase 4: April 2009	1PKP	75.3%	Bacillus anthracis

IDP04383 (show subtarget assignments)	1	purified	BAS4455	49187450		phenylalanyl-tRNA synthetase subunit bet...	806	Proposed to be essential proteins	Phase 4: April 2009	2RHS	49.8%	Bacillus anthracis

IDP04730 (show subtarget assignments)	1	cloned	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP01761
(show subtarget assignments)

1

cloned

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02439
(show subtarget assignments)

1

cloned

GBAA3892

47529180

serine protease [Bacillus anthracis str....

613

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2OXA

16.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02558
(show subtarget assignments)

1

cloned

GBAA4584

47529880

vpR

minor extracellular protease VpR [Bacill...

917

Drug target motif; Drug target functions

Phase 3: June 2008

3EIF

22.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02432
(show subtarget assignments)

1

soluble

GBAA3687

47528971

acetyl-CoA acetyltransferase [Bacillus a...

363

Drug target motif; Conserved; Essential; Involved in sporulation; Drug target fu...

Phase 3: June 2008

4DD5

39.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP02574
(show subtarget assignments)

1

cloned

GBAA1995

47527292

protease, putative [Bacillus anthracis s...

386

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02746
(show subtarget assignments)

1

soluble

GBAA0157

47525415

glmM

phosphoglucosamine mutase [Bacillus anth...

448

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PDK

100%

Bacillus anthracis

Cell envelope

N/A

IDP02560
(show subtarget assignments)

1

cloned

GBAA0268

47777798

guaA

bifunctional GMP synthase/glutamine amid...

512

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPM

52.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01610
(show subtarget assignments)

1

in_pdb
3I1I

GBAA4983

47778350

homoserine O-acetyltransferase [Bacillus...

374

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I1I

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02534
(show subtarget assignments)

1

cloned

GBAA4614

47529912

Holliday junction resolvase-like protein...

137

Conserved;

Phase 3: June 2008

1VHX

70.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01752
(show subtarget assignments)

1

selected

GBAA5282

47778383

nprB

neutral protease B [Bacillus anthracis s...

547

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1KEI

31.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02535
(show subtarget assignments)

1

expressed

GBAA0088

47525343

cysE

serine O-acetyltransferase [Bacillus ant...

221

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GVD

36.2%

Bacillus anthracis

Amino acid biosynthesis

Serine family

IDP02537
(show subtarget assignments)

0

work_stopped

GBAA4558

47778307

nadD

nicotinic acid mononucleotide adenylyltr...

171

Conserved; Drug target functions

Phase 3: June 2008

2QTM

99.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP02533
(show subtarget assignments)

1

expressed

GBAA4184

47529480

pdhA

pyruvate dehydrogenase complex E1 compon...

371

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

80.9%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP02758
(show subtarget assignments)

1

cloned

GBAA_pXO2_0073

47566739

signal peptidase i, (pxo2-59) [Bacillus ...

183

Drug target motif;

Phase 3: June 2008

1B12

8.7%

Bacillus anthracis

N/A

IDP01736
(show subtarget assignments)

1

expressed

GBAA5503

47530821

sensor histidine kinase [Bacillus anthra...

476

Conserved; Drug target functions

Phase 3: June 2008

2C2A

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02549
(show subtarget assignments)

1

soluble

GBAA0547

47525820

RNA methyltransferase [Bacillus anthraci...

162

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L8U

51.2%

Bacillus anthracis

Protein synthesis

tRNA and rRNA base modification

IDP02525
(show subtarget assignments)

1

crystallized

GBAA4351

47529646

argF

ornithine carbamoyltransferase [Bacillus...

316

Conserved; Drug target functions

Phase 3: June 2008

1A1S

55.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02528
(show subtarget assignments)

1

soluble

GBAA4405

47529699

folD

methylenetetrahydrofolate dehydrogenase/...

286

Essential; Drug target functions

Phase 3: June 2008

3P2O

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02523
(show subtarget assignments)

1

cloned

GBAA4297

47529591

dacF

D-alanyl-D-alanine carboxypeptidase [Bac...

396

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IT9

32.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01794
(show subtarget assignments)

1

purified

GBAA1026

47526305

glpK

glycerol kinase [Bacillus anthracis str....

496

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3G25

75%

Bacillus anthracis

Energy metabolism

Other

IDP02524
(show subtarget assignments)

1

purified

GBAA1852

47527143

ilvC-2

ketol-acid reductoisomerase [Bacillus an...

335

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

56.1%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02763
(show subtarget assignments)

1

cloned

GBAA2547

47527836

acyl-CoA dehydrogenase [Bacillus anthrac...

381

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VIG

50.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP01726
(show subtarget assignments)

1

cloned

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01606
(show subtarget assignments)

1

cloned

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP02531
(show subtarget assignments)

1

in_pdb
3LAC

GBAA3090

50196941

pcP

pyrrolidone-carboxylate peptidase [Bacil...

215

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LAC

99.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02767
(show subtarget assignments)

1

cloned

GBAA4750

47530050

D-alanyl-D-alanine carboxypeptidase fami...

259

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01723
(show subtarget assignments)

1

in_pdb
3KAX

GBAA5138

47530443

aminotransferase, classes I and II [Baci...

383

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3KAX

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01724
(show subtarget assignments)

1

expressed

GBAA5248

47530553

acetyl-CoA acetyltransferase [Bacillus a...

390

Conserved; Essential; Drug target functions

Phase 3: June 2008

2C7Y

47.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP02575
(show subtarget assignments)

1

cloned

GBAA5123

47778366

glgB

glycogen branching enzyme [Bacillus anth...

645

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K1D

43.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02312
(show subtarget assignments)

1

expressed

GBAA2190

47778017

FtsK/SpoIIIE family protein [Bacillus an...

1342

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IUT

7.4%

Bacillus anthracis

Cellular processes

Cell division

IDP01725
(show subtarget assignments)

0

work_stopped

GBAA2534

47527824

acetyltransferase [Bacillus anthracis st...

168

CONSERVED

Phase 3: June 2008

3FBU

100%

Bacillus anthracis

N/A

IDP02532
(show subtarget assignments)

1

cloned

GBAA1879

47527172

M23/37 family peptidase [Bacillus anthra...

262

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01712
(show subtarget assignments)

1

in_pdb
3EFE

GBAA2657

47551781

thiJ/pfpI family protein [Bacillus anthr...

210

CONSERVED

Phase 3: June 2008

3EFE

100%

Bacillus anthracis

N/A

IDP01540
(show subtarget assignments)

1

in_pdb
3EC6

GBAA0418

47525694

general stress protein 26 [Bacillus anth...

138

CONSERVED

Phase 3: June 2008

3EC6

100%

Bacillus anthracis

IDP01711
(show subtarget assignments)

1

expressed

GBAA5380

47530690

clpP

ATP-dependent Clp protease proteolytic s...

193

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TT7

89.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01710
(show subtarget assignments)

1

purified

GBAA0371

47525642

glycosyl hydrolase family protein [Bacil...

554

Conserved; Drug target functions

Phase 3: June 2008

2ZE0

67%

Bacillus anthracis

Energy metabolism

Sugars

IDP00002
(show subtarget assignments)

1

expressed

GBAA_pXO1_0079

47566400

-

surface layer protein, (pxo1-54)

404

Drug Target Homolog

Phase 1: October 2007

3PYW

14.4%

Bacillus anthracis

IDP02320
(show subtarget assignments)

1

purified

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01704
(show subtarget assignments)

1

expressed

GBAA5215

47530521

aminotransferase, class V [Bacillus anth...

406

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T3I

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01640
(show subtarget assignments)

1

purified

GBAA4357

47529653

short chain dehydrogenase/reductase fami...

264

Conserved; Essential;

Phase 3: June 2008

3P19

33.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01702
(show subtarget assignments)

1

soluble

GBAA0261

47525520

gcP

O-sialoglycoprotein endopeptidase [Bacil...

338

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IVN

35.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02325
(show subtarget assignments)

1

in_pdb
3IMF

GBAA4204

47778260

short chain dehydrogenase [Bacillus anth...

254

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3IMF

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01639
(show subtarget assignments)

1

cloned

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01719
(show subtarget assignments)

1

purified

GBAA5560

47530880

ribose-5-phosphate isomerase B [Bacillus...

147

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HE8

55.1%

Bacillus anthracis

Energy metabolism

Sugars

IDP01695
(show subtarget assignments)

1

expressed

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

Phase 3: June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02329
(show subtarget assignments)

1

in_pdb
3KQF

GBAA2551

47527840

enoyl-CoA hydratase [Bacillus anthracis ...

262

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3KQF

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04136
(show subtarget assignments)

1

purified

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02427
(show subtarget assignments)

1

purified

GBAA3553

47528837

pepF-2

oligoendopeptidase F [Bacillus anthracis...

595

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QR4

37.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01683
(show subtarget assignments)

1

expressed

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02335
(show subtarget assignments)

1

expressed

GBAA2583

47527873

hypothetical protein GBAA2583 [Bacillus ...

563

Drug target motif; Involved in sporulation;

Phase 3: June 2008

3SKS

26.3%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01682
(show subtarget assignments)

1

cloned

GBAA5104

47530405

D-alanyl-D-alanine carboxypeptidase fami...

286

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04109
(show subtarget assignments)

1

crystallized

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02518
(show subtarget assignments)

1

purified

GBAA5557

47530877

upp

uracil phosphoribosyltransferase [Bacill...

209

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1I5E

84.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02338
(show subtarget assignments)

1

cloned

GBAA1456

47526731

sensor histidine kinase [Bacillus anthra...

351

Conserved; Drug target functions

Phase 3: June 2008

3EHH

14.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01681
(show subtarget assignments)

1

cloned

GBAA4795

47530092

hypothetical protein GBAA4795 [Bacillus ...

572

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3AU2

37.1%

Bacillus anthracis

Unknown function

General

IDP02519
(show subtarget assignments)

1

cloned

GBAA1494

47526768

resA

thiol-disulfide oxidoreductase [Bacillus...

173

Conserved; Drug target functions

Phase 3: June 2008

1ST9

41.6%

Bacillus anthracis

Energy metabolism

Electron transport

IDP01675
(show subtarget assignments)

1

purified

GBAA5217

47530523

ABC transporter ATP-binding protein [Bac...

261

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2D2E

57.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02346
(show subtarget assignments)

1

cloned

GBAA2832

47528125

dapA-1

dihydrodipicolinate synthase [Bacillus a...

298

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NA8

34.2%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01673
(show subtarget assignments)

1

soluble

GBAA5206

47530513

M23/37 family peptidase [Bacillus anthra...

327

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

3SLU

25.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01668
(show subtarget assignments)

1

soluble

GBAA0060

47525314

hypothetical protein GBAA0060 [Bacillus ...

160

Essential;

Phase 3: June 2008

2K4K

29.4%

Bacillus anthracis

Unknown function

General

IDP01670
(show subtarget assignments)

1

cloned

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

Phase 3: June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02795
(show subtarget assignments)

1

in_pdb
3LNO

GBAA5281

47530589

hypothetical protein GBAA5281 [Bacillus ...

105

Conserved; Involved in sporulation;

Phase 3: June 2008

3LNO

100%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02513
(show subtarget assignments)

1

soluble

GBAA0258

47525517

hypothetical protein GBAA0258 [Bacillus ...

157

Conserved;

Phase 3: June 2008

1FL9

30.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01672
(show subtarget assignments)

1

soluble

GBAA5133

47530438

hypothetical protein GBAA5133 [Bacillus ...

396

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1DJU

48.2%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01677
(show subtarget assignments)

1

soluble

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP01663
(show subtarget assignments)

1

purified

GBAA4696

47529995

hemC

porphobilinogen deaminase [Bacillus anth...

309

Conserved; Drug target functions

Phase 3: June 2008

1AH5

46.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01666
(show subtarget assignments)

1

soluble

GBAA4704

47530003

clpX

ATP-dependent protease ATP-binding subun...

419

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HTE

52.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02490
(show subtarget assignments)

1

purified

GBAA3974

47529264

sucC

succinyl-CoA synthetase subunit beta [Ba...

386

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CQI

54.7%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04076
(show subtarget assignments)

1

expressed

GBAA2213

47527506

sensor histidine kinase [Bacillus anthra...

452

putative drug target function;

Phase 4: April 2009

2C2A

18.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP02802
(show subtarget assignments)

1

cloned

GBAA3471

47528757

short chain dehydrogenase/reductase fami...

234

Conserved; Essential;

Phase 3: June 2008

1SNY

26.8%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01661
(show subtarget assignments)

1

soluble

GBAA4609

47529906

U32 family peptidase [Bacillus anthracis...

426

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01678
(show subtarget assignments)

1

cloned

GBAA5591

47530913

cardiolipin synthetase domain-containing...

397

Drug target motif; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01626
(show subtarget assignments)

1

cloned

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02245
(show subtarget assignments)

1

cloned

GBAA1751

47527043

asnO-2

asparagine synthetase, glutamine-hydroly...

607

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CT9

25.9%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01605
(show subtarget assignments)

1

soluble

GBAA4560

47529856

hypothetical protein GBAA4560 [Bacillus ...

97

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1RQ8

67%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02517
(show subtarget assignments)

1

soluble

GBAA2315

47527614

S-layer protein, putative [Bacillus anth...

383

Drug target motif; Drug target functions

Phase 3: June 2008

3PYW

15.9%

Bacillus anthracis

Cell envelope

Surface structures

IDP02576
(show subtarget assignments)

1

purified

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02374
(show subtarget assignments)

1

purified

GBAA3116

47528407

ppsA

phosphoenolpyruvate synthase [Bacillus a...

868

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OLS

15.7%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01917
(show subtarget assignments)

1

soluble

GBAA1429

47526701

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

239

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VZW

36.5%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02734
(show subtarget assignments)

1

cloned

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP01795
(show subtarget assignments)

1

expressed

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04028
(show subtarget assignments)

1

soluble

BAS0109

49183143

30S ribosomal protein S10 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1P6G

61.8%

Bacillus anthracis

IDP04057
(show subtarget assignments)

1

purified

BAS0125

49183159

50S ribosomal protein L6 [Bacillus anthr...

179

Proposed to be essential proteins

Phase 4: April 2009

1C04

74.9%

Bacillus anthracis

IDP05023
(show subtarget assignments)

1

expressed

BAS2353

49185362

-

hemolysin II, C-terminal [Bacillus anthr...

240

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3ANZ

27.9%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP05024
(show subtarget assignments)

1

soluble

BAS4675

49187666

-

ABC transporter, substrate-binding prote...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

20.6%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP04027
(show subtarget assignments)

1

cloned

BAS4637

49187628

leucyl-tRNA synthetase [Bacillus anthrac...

802

Proposed to be essential proteins

Phase 4: April 2009

1H3N

45.9%

Bacillus anthracis

IDP05025
(show subtarget assignments)

1

cloned

BAS4742

49187733

-

hypothetical protein BAS4742 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP04005
(show subtarget assignments)

1

purified

BAS4355

49187350

valyl-tRNA synthetase [Bacillus anthraci...

881

Proposed to be essential proteins

Phase 4: April 2009

1GAX

42.6%

Bacillus anthracis

IDP04003
(show subtarget assignments)

1

cloned

BAS0126

49183160

50S ribosomal protein L18 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1OVY

75.8%

Bacillus anthracis

IDP05142
(show subtarget assignments)

1

cloned

BAS2027

49185038

-

isoleucyl-tRNA synthetase [Bacillus anth...

1033

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ILE

38.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05141
(show subtarget assignments)

1

cloned

BAS2021

49185032

argS

arginyl-tRNA synthetase [Bacillus anthra...

562

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1BS2

36.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05140
(show subtarget assignments)

1

soluble

BAS0382

49183410

-

prolyl-tRNA synthetase [Bacillus anthrac...

508

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H4Q

48.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05139
(show subtarget assignments)

1

soluble

BAS0353

49183381

-

amino acid ABC transporter, solute bindi...

264

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQL

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05452
(show subtarget assignments)

1

cloned

BAS5207

49188193

-

collagen adhesion protein, C-terminal [B...

882

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3KPT

12.6%

Bacillus anthracis

Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05421
(show subtarget assignments)

1

soluble

BAS1418

49184435

-

hypothetical protein BAS1418 [Bacillus a...

237

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05453
(show subtarget assignments)

1

purified

BAS5213

49188199

-

arginyl-tRNA synthetase [Bacillus anthra...

556

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.8%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP04416
(show subtarget assignments)

1

purified

BAS4049

49187047

ribonuclease Z [Bacillus anthracis str. ...

307

Proposed to be essential proteins

Phase 4: April 2009

1Y44

61.2%

Bacillus anthracis

IDP04064
(show subtarget assignments)

1

expressed

BAS0127

49183161

30S ribosomal protein S5 [Bacillus anthr...

166

Proposed to be essential proteins

Phase 4: April 2009

1PKP

75.3%

Bacillus anthracis

IDP04383
(show subtarget assignments)

1

purified

BAS4455

49187450

phenylalanyl-tRNA synthetase subunit bet...

806

Proposed to be essential proteins

Phase 4: April 2009

2RHS

49.8%

Bacillus anthracis

IDP04730
(show subtarget assignments)

1

cloned

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

Targets