Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04338 (show subtarget assignments)	1	cloned	CPF_1446	110801179	sodF	Mn/Fe superoxide dismutase [Clostridium ...	227	conserved gene; putative drug target function;	Phase 4: April 2009	1JR9	44.9%	Clostridium perfringens	Cellular processes	Detoxification

IDP00633 (show subtarget assignments)	1	soluble	SACOL0118	57286667	sodA1	superoxide dismutase	199	Conserved Gene / Pathway	Phase 2: March 2008	1JR9	64.5%	Staphylococcus aureus	Cellular processes	Detoxification

IDP02401 (show subtarget assignments)	1	cloned	Cj0574	15791934	ilvI	acetolactate synthase 3 catalytic subuni...	566	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1JSC	40.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04355 (show subtarget assignments)	1	purified	YPO0539	115346347	ilvI	acetolactate synthase isozyme III large ...	575	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1JSC	43.1%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP04333 (show subtarget assignments)	1	cloned	VC2483	9657062		acetolactate synthase III, large subunit...	573	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1JSC	42.8%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP04314 (show subtarget assignments)	1	purified	YPCD1.73c	5832493	YPCD1.73c	hypothetical protein YPCD1.73c [Yersinia...	149	virulence factor; conserved gene;	Phase 4: April 2009	1JSC	40.7%	Yersinia pestis

IDP01883 (show subtarget assignments)	1	expressed	STM0116	16763506	ilvI	acetolactate synthase 3 catalytic subuni...	553	Conserved; Drug target functions	Phase 3: June 2008	1JSC	43.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP02192 (show subtarget assignments)	1	soluble	YPO0348	16120683	aspA	aspartate ammonia-lyase [Yersinia pestis...	478	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1JSW	89.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02048 (show subtarget assignments)	1	expressed	STM3737	16767022		putative Zn-dependent hydrolase [Salmone...	293	Conserved; Drug target functions	Phase 3: June 2008	1JT1	30.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00819 (show subtarget assignments)	1	purified	SACOL2161	57286374		UTP-glucose-1-phosphate uridylyltransfer...	395	Conserved Gene / Pathway	Phase 2: March 2008	1JV1	33.8%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04735 (show subtarget assignments)	1	purified	YPO1494	115347246	chlN	molybdopterin biosynthesis protein [Yers...	255	conserved gene; putative drug target function;	Phase 4: April 2009	1JW9	67.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP00940 (show subtarget assignments)	1	soluble	STM0845	16764207	moeB	molybdopterin biosynthesis protein MoeB ...	249	Conserved Gene / Pathway	Phase 2: March 2008	1JW9	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP05258 (show subtarget assignments)	1	cloned	CD2761	126700377		putative N-acetylmuramoyl-L-alanine amid...	301	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JWQ	23.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05489 (show subtarget assignments)	1	cloned	CD0106	126697677	cwlD	germination-specific N-acetylmuramoyl-L-...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JWQ	25.6%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP01677 (show subtarget assignments)	1	soluble	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP05186 (show subtarget assignments)	1	cloned	CD0120	126697692	glmS	glucosamine--fructose-6-phosphate aminot...	610	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JXA	47.1%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP00693 (show subtarget assignments)	1	purified	SACOL2145	57286359	glmS	D-fructose-6-phosphate amidotransferase ...	601	Drug Target Function	Phase 2: March 2008	1JXA	41.4%	Staphylococcus aureus	Central intermediary metabolism	Amino sugars

IDP01927 (show subtarget assignments)	1	expressed	CBU_1787	29542344	glmS	glucosamine--fructose-6-phosphate aminot...	611	Conserved; Drug target functions	Phase 3: June 2008	1JXA	58.3%	Coxiella burnetii	Central intermediary metabolism	Amino sugars

IDP00324 (show subtarget assignments)	1	cloned	Cj1366c	15792689	glmS	D-fructose-6-phosphate amidotransferase ...	598	Drug Target Function	Phase 2: March 2008	1JXA	41.3%	Campylobacter jejuni	Unclassified	Unclassified

IDP90884 (show subtarget assignments)	8	purified	VC1296	15641309		phosphomethylpyrimidine kinase [Vibrio c...	282	Predicted Essential	Community Requests	1JXH	43.6%	Vibrio cholerae

IDP01956 (show subtarget assignments)	1	cloned	STM2061	16765391	sbmC	DNA gyrase inhibitor [Salmonella typhimu...	155	Conserved; Drug target homolg; Drug target functions	Phase 3: June 2008	1JYH	71%	Salmonella enterica	Unknown function	General

IDP90930 (show subtarget assignments)	8	cloned	YPO3384	16123533	mtn	5'-methylthioadenosine/S-adenosylhomocys...	233	Predicted Essential	Community Requests	1JYS	74.7%	Yersinia pestis

IDP02103 (show subtarget assignments)	1	expressed	YPO0891	16121196	dsbC	thiol:disulfide interchange protein DsbC...	238	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 3: June 2008	1JZD	61.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP01458 (show subtarget assignments)	1	soluble	VC2418	15642415		thiol:disulfide interchange protein DsbC...	250	Drug Target Function	Phase 2: March 2008	1JZD	38.4%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP04527 (show subtarget assignments)	1	cloned	STM1824_1_454	16765165	pabB	para-aminobenzoate synthase component I ...	454	Salmonella essential protein	Phase 4: April 2009	1K0E	76.2%	Salmonella enterica

IDP90779 (show subtarget assignments)	8	cloned	YPO3497	16123643	nusA	transcription elongation factor NusA [Ye...	495	Predicted Essential	Community Requests	1K0R	24.4%	Yersinia pestis

IDP90106 (show subtarget assignments)	8	cloned	MPXV_ZAI1979_005_011	68449085		secreted epidermal growth factor-like pr...	142	similar to VACV-COP-C11R, MPXV-ZAI96-D3R	Community Requests	1K36	16.2%	Monkeypox virus

IDP90175 (show subtarget assignments)	8	expressed	AAM13468.1	20153007	VGF	CPXV021 protein or CPXV VGF protein	139	similar to viral growth factor C11R vaccinia virus	Community Requests	1K36	15.8%	Cowpox virus	host range protein	0

IDP04280 (show subtarget assignments)	1	purified	YPO1108	115346887	gltA	citrate synthase GltA [Yersinia pestis C...	426	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1K3P	86.6%	Yersinia pestis	Energy metabolism	TCA cycle

IDP91458 (show subtarget assignments)	8	soluble	VV1_0162	27363645	gltA	type II citrate synthase [Vibrio vulnifi...	429	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1K3P	75.5%	Vibrio vulnificus

IDP04306 (show subtarget assignments)	8	selected	CAC05809	12329078	ipgE	IpgE, cytoplasmic chaperone for IpgD [Sh...	120	Shigella effector protein	Community Requests	1K3S	27.5%	Shigella flexneri

IDP90767 (show subtarget assignments)	8	soluble	YPO2607	16122820	nadD	nicotinic acid mononucleotide adenylyltr...	220	Predicted Essential	Community Requests	1K4K	56.4%	Yersinia pestis

IDP00932 (show subtarget assignments)	1	purified	STM0645	16764022	nadD	nicotinic acid mononucleotide adenyltran...	213	Conserved Gene / Pathway	Phase 2: March 2008	1K4K	85.4%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00914 (show subtarget assignments)	1	soluble	STM0220	16763610	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	398	Conserved Gene / Pathway	Phase 2: March 2008	1K5H	88.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04402 (show subtarget assignments)	1	cloned	VC2254	15642252		1-deoxy-D-xylulose 5-phosphate reductois...	402	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K5H	60.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00997 (show subtarget assignments)	1	soluble	STM2314	16765641		putative chemotaxis signal transduction ...	333	Conserved Gene / Pathway	Phase 2: March 2008	1K68	12%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP90730 (show subtarget assignments)	8	purified	Cj1598	15792903	hisD	histidinol dehydrogenase [Campylobacter ...	428	Predicted Essential	Community Requests	1K75	59.8%	Campylobacter jejuni

IDP01913 (show subtarget assignments)	1	cloned	GBAA1426	47526698	hisD	histidinol dehydrogenase [Bacillus anthr...	429	Conserved; Drug target functions	Phase 3: June 2008	1K75	39.2%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02636 (show subtarget assignments)	1	expressed	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04641 (show subtarget assignments)	1	purified	FTT0693c	56707813	mutM	formamidopyrimidine-DNA glycosylase [Fra...	274	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1K82	43.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP05771 (show subtarget assignments)	1	cloned	Z0339	12513053		alpha replication protein of prophage CP...	777	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1KA8	9.5%	Escherichia coli	Mobile and extrachromosomal element functions: Prophage functions

IDP04502 (show subtarget assignments)	1	purified	VC1136	9655608		amidotransferase HisH [Vibrio cholerae O...	203	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KA9	36.9%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP02271 (show subtarget assignments)	1	purified	FTT1155c	56708226	aroK	shikimate kinase I [Francisella tularens...	176	Conserved; Drug target functions	Phase 3: June 2008	1KAG	58%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP04177 (show subtarget assignments)	1	purified	VC2629	9657219		shikimate kinase [Vibrio cholerae O1 bio...	174	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KAG	81%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP05299 (show subtarget assignments)	1	soluble	CD2524	126700141	nadD	nicotinate-nucleotide adenylyltransferas...	229	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KAM	34.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP90518 (show subtarget assignments)	8	purified	Cj1404	15792722		hypothetical protein Cj1404 [Campylobact...	181	Predicted Essential	Community Requests	1KAM	30.2%	Campylobacter jejuni

IDP90837 (show subtarget assignments)	8	selected	S2226	30063491	rfbD	dTDP-4-dehydrorhamnose reductase [Shigel...	299	Predicted Essential	Community Requests	1KBZ	85.6%	Shigella flexneri

IDP90561 (show subtarget assignments)	8	cloned	YPO1391	16121671	cmk	cytidylate kinase [Yersinia pestis CO92]...	230	Predicted Essential	Community Requests	1KDO	83%	Yersinia pestis

IDP00048 (show subtarget assignments)	1	cloned	BA_3330	30257875		beta-lactam antibiotic acylase family pr...	796	Virulence	Phase 1: October 2007	1KEH	22.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01752 (show subtarget assignments)	1	selected	GBAA5282	47778383	nprB	neutral protease B [Bacillus anthracis s...	547	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1KEI	31.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02190 (show subtarget assignments)	1	expressed	YPO0360	16120695	frdA	fumarate reductase flavoprotein subunit ...	607	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1KF6	85.2%	Yersinia pestis	Energy metabolism	Anaerobic

IDP00546 (show subtarget assignments)	1	expressed	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP01474 (show subtarget assignments)	1	expressed	VC2657	15642652		fumarate reductase iron-sulfur subunit	252	Conserved Gene / Pathway	Phase 2: March 2008	1KF6	69%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP02619 (show subtarget assignments)	1	cloned	GBAA1372	47526645	nrdF	ribonucleotide-diphosphate reductase sub...	322	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1KGN	44.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP01785 (show subtarget assignments)	1	expressed	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02231 (show subtarget assignments)	1	purified	lmo1377	16803417	lisR	two-component response regulator [Lister...	226	Known virulence-Regulation; Predicted virulence-Resistance to antibiotics and to...	Phase 3: June 2008	1KGS	41.4%	Listeria monocytogenes	Regulatory functions	Other

IDP91359 (show subtarget assignments)	8	purified	VV1_2847	27366129		response regulator [Vibrio vulnificus CM...	219	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1KGS	41.1%	Vibrio vulnificus

IDP91233 (show subtarget assignments)	8	selected	NT04EC1775	26107994	trpD	Anthranilate synthase component II [Esch...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP04161 (show subtarget assignments)	1	cloned	VC1172	9655648		anthranilate phosphoribosyltransferase [...	353	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KGZ	59.5%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP91301 (show subtarget assignments)	8	selected	STM1724	16765068	trpD	anthranilate phosphoribosyltransferase	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.1%	Salmonella enterica

IDP91240 (show subtarget assignments)	8	selected	HP1280	0			335	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	39.4%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP91224 (show subtarget assignments)	8	selected	SF1266	24112662	trpD	bifunctional glutamine amidotransferase/...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	46.7%	Shigella flexneri

IDP91288 (show subtarget assignments)	8	selected	SPA1153	56413351	trpD	bifunctional glutamine amidotransferase/...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Salmonella enterica

IDP00054 (show subtarget assignments)	1	crystallized	BA_3600	30258128		acetyltransferase, CYSE/LACA/LPXA/NODL f...	185	Virulence	Phase 1: October 2007	1KHR	42.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02750 (show subtarget assignments)	1	cloned	GBAA5389	47530699		transferase hexapeptide domain-containin...	170	Conserved; Essential; Drug target functions	Phase 3: June 2008	1KHR	28.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP00043 (show subtarget assignments)	1	purified	BA_2629	30257246		acetyltransferase, CYSE/LACA/LPXA/NODL f...	210	Virulence	Phase 1: October 2007	1KHR	59.5%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91546 (show subtarget assignments)	8	selected	AAA26683	398085	vat	acetyltransferase [Staphylococcus aureus...	219	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KHR	57.5%	Staphylococcus aureus

IDP91687 (show subtarget assignments)	8	selected	NP_000292	4505881	PLG	plasminogen isoform 1 precursor [Homo sa...	810	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1KI0	31.1%	Homo sapiens

IDP04404 (show subtarget assignments)	1	cloned	VC2602	15642597		adenylosuccinate synthetase [Vibrio chol...	432	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KJX	75.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01954 (show subtarget assignments)	1	purified	Cj0812	15792150	thrC	threonine synthase [Campylobacter jejuni...	470	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1KL7	33.2%	Campylobacter jejuni	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90816 (show subtarget assignments)	8	soluble	YPO2878	16123070	hisS	histidyl-tRNA synthetase [Yersinia pesti...	424	Predicted Essential	Community Requests	1KMM	82.1%	Yersinia pestis

IDP90628 (show subtarget assignments)	8	purified	VC0760	15640779	hisS	histidyl-tRNA synthetase [Vibrio cholera...	422	Predicted Essential	Community Requests	1KMM	74.5%	Vibrio cholerae

IDP00434 (show subtarget assignments)	1	cloned	YPO0796	16121108	lysA	diaminopimelate decarboxylase	420	Drug Target Function	Phase 2: March 2008	1KNW	76.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01126 (show subtarget assignments)	1	cloned	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00931 (show subtarget assignments)	1	expressed	STM0615	16763992	ybdR	putative dehydrogenase	412	Essential Gene	Phase 2: March 2008	1KOL	32.5%	Salmonella enterica	Central intermediary metabolism	Other

IDP04681 (show subtarget assignments)	1	soluble	GBAA3131	47528422	adhB	alcohol dehydrogenase, zinc-containing [...	377	virulence factor; putative drug target function;	Phase 4: April 2009	1KOL	31.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP91011 (show subtarget assignments)	8	soluble	y2255	22126141		hypothetical protein y2255 [Yersinia pes...	251	other biological interest / possibly involved in quorum sensing	Community Requests	1KON	83.3%	Yersinia pestis

IDP91710 (show subtarget assignments)	8	selected	NP_006353	15487670	NXF1	nuclear RNA export factor 1 isoform 1 [H...	619	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1KOO	44.6%	Homo sapiens

IDP00962 (show subtarget assignments)	1	cloned	STM1427	16764775	cfa	cyclopropane fatty acyl phospholipid syn...	382	Drug Target Function	Phase 2: March 2008	1KP9	26.7%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP05651 (show subtarget assignments)	1	soluble	Cj1183c	6968610	cfa	guanylate kinase [Campylobacter jejuni s...	387	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1KP9	27.9%	Campylobacter jejuni	Fatty acid and phospholipid metabolism: Biosynthesis

IDP01412 (show subtarget assignments)	1	soluble	VC1122	15641135		cyclopropane-fatty-acyl-phospholipid syn...	432	Drug Target Function	Phase 2: March 2008	1KPI	18.7%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00228 (show subtarget assignments)	1	cloned	YPO3388	16123537	-	putative chloride channel protein	441	Virulence	Phase 1: October 2007	1KPL	76.6%	Yersinia pestis	Transcription	Transcription factors

IDP00928 (show subtarget assignments)	1	purified	STM0602	16763979	ybdH	putative glycerol dehydrogenase	362	Conserved Gene / Pathway	Phase 2: March 2008	1KQ3	31.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP04303 (show subtarget assignments)	1	cloned	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP00543 (show subtarget assignments)	1	soluble	YPO4057	16124173	fdoH	formate dehydrogenase-O, iron-sulfur sub...	323	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	70.9%	Yersinia pestis	Energy metabolism	Anaerobic

IDP01518 (show subtarget assignments)	1	soluble	VC1512	15641521		formate dehydrogenase, iron-sulfur subun...	202	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	29%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP02074 (show subtarget assignments)	1	cloned	STM3149	16766449	hybA	hydrogenase 2 protein HybA [Salmonella t...	328	Conserved; Drug target functions	Phase 3: June 2008	1KQF	29.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01841 (show subtarget assignments)	1	purified	STM2549	16765869	asrB	anaerobic sulfite reductase subunit B [S...	272	Conserved; Drug target functions	Phase 3: June 2008	1KRH	18.8%	Salmonella enterica	Energy metabolism	Anaerobic

IDP91897 (show subtarget assignments)	8	selected	SpneCM_010100007685	298255467		oxidoreductase, NAD-binding protein [Str...	396	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1KRH	13.4%	Streptococcus pneumoniae

IDP04140 (show subtarget assignments)	1	cloned	YPO3116	115348760	ascD	cdp-6-deoxy-delta-3,4-glucoseen reductas...	329	virulence factor; putative drug target function;	Phase 4: April 2009	1KRH	26.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04504 (show subtarget assignments)	1	cloned	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01335 (show subtarget assignments)	1	soluble	VC1144	15641157	clpA	ATP-dependent Clp protease ATP-binding s...	756	Drug Target Function	Phase 2: March 2008	1KSF	77.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91360 (show subtarget assignments)	8	cloned	VV1_2843	27366125		16S rRNA uridine-516 pseudouridylate syn...	233	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1KSK	55.4%	Vibrio vulnificus

IDP90285 (show subtarget assignments)	8	selected	TGME49_083850	211966798		peptidyl-prolyl isomerase, putative [Tox...	521	The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...	Community Requests	1KT0	23.2%	Toxoplasma gondii

IDP90347 (show subtarget assignments)	8	soluble	CT205	15604925	pfkA_1	diphosphate--fructose-6-phosphate 1-phos...	553	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KZH	36.9%	Chlamydia trachomatis

IDP90507 (show subtarget assignments)	8	soluble	VC2270	15642268		riboflavin synthase subunit alpha [Vibri...	217	Predicted Essential	Community Requests	1KZL	35.5%	Vibrio cholerae

IDP90684 (show subtarget assignments)	8	purified	Cj1218c	15792542	ribA	riboflavin synthase subunit alpha [Campy...	203	Predicted Essential	Community Requests	1KZL	29.6%	Campylobacter jejuni

IDP02186 (show subtarget assignments)	1	soluble	FTT1672	56708682	ribB	riboflavin synthase subunit alpha [Franc...	201	Conserved; Drug target functions	Phase 3: June 2008	1KZL	35.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05517 (show subtarget assignments)	1	soluble	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01025 (show subtarget assignments)	1	cloned	STM1196	16764551	acpP	acyl carrier protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1L0H	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04338
(show subtarget assignments)

1

cloned

CPF_1446

110801179

sodF

Mn/Fe superoxide dismutase [Clostridium ...

227

conserved gene; putative drug target function;

Phase 4: April 2009

1JR9

44.9%

Clostridium perfringens

Cellular processes

Detoxification

IDP00633
(show subtarget assignments)

1

soluble

SACOL0118

57286667

sodA1

superoxide dismutase

199

Conserved Gene / Pathway

Phase 2: March 2008

1JR9

64.5%

Staphylococcus aureus

Cellular processes

Detoxification

IDP02401
(show subtarget assignments)

1

cloned

Cj0574

15791934

ilvI

acetolactate synthase 3 catalytic subuni...

566

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1JSC

40.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04355
(show subtarget assignments)

1

purified

YPO0539

115346347

ilvI

acetolactate synthase isozyme III large ...

575

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1JSC

43.1%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP04333
(show subtarget assignments)

1

cloned

VC2483

9657062

acetolactate synthase III, large subunit...

573

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1JSC

42.8%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP04314
(show subtarget assignments)

1

purified

YPCD1.73c

5832493

YPCD1.73c

hypothetical protein YPCD1.73c [Yersinia...

149

virulence factor; conserved gene;

Phase 4: April 2009

1JSC

40.7%

Yersinia pestis

IDP01883
(show subtarget assignments)

1

expressed

STM0116

16763506

ilvI

acetolactate synthase 3 catalytic subuni...

553

Conserved; Drug target functions

Phase 3: June 2008

1JSC

43.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP02192
(show subtarget assignments)

1

soluble

YPO0348

16120683

aspA

aspartate ammonia-lyase [Yersinia pestis...

478

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1JSW

89.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02048
(show subtarget assignments)

1

expressed

STM3737

16767022

putative Zn-dependent hydrolase [Salmone...

293

Conserved; Drug target functions

Phase 3: June 2008

1JT1

30.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00819
(show subtarget assignments)

1

purified

SACOL2161

57286374

UTP-glucose-1-phosphate uridylyltransfer...

395

Conserved Gene / Pathway

Phase 2: March 2008

1JV1

33.8%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04735
(show subtarget assignments)

1

purified

YPO1494

115347246

chlN

molybdopterin biosynthesis protein [Yers...

255

conserved gene; putative drug target function;

Phase 4: April 2009

1JW9

67.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP00940
(show subtarget assignments)

1

soluble

STM0845

16764207

moeB

molybdopterin biosynthesis protein MoeB ...

249

Conserved Gene / Pathway

Phase 2: March 2008

1JW9

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP05258
(show subtarget assignments)

1

cloned

CD2761

126700377

putative N-acetylmuramoyl-L-alanine amid...

301

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JWQ

23.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05489
(show subtarget assignments)

1

cloned

CD0106

126697677

cwlD

germination-specific N-acetylmuramoyl-L-...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JWQ

25.6%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP01677
(show subtarget assignments)

1

soluble

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP05186
(show subtarget assignments)

1

cloned

CD0120

126697692

glmS

glucosamine--fructose-6-phosphate aminot...

610

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JXA

47.1%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP00693
(show subtarget assignments)

1

purified

SACOL2145

57286359

glmS

D-fructose-6-phosphate amidotransferase ...

601

Drug Target Function

Phase 2: March 2008

1JXA

41.4%

Staphylococcus aureus

Central intermediary metabolism

Amino sugars

IDP01927
(show subtarget assignments)

1

expressed

CBU_1787

29542344

glmS

glucosamine--fructose-6-phosphate aminot...

611

Conserved; Drug target functions

Phase 3: June 2008

1JXA

58.3%

Coxiella burnetii

Central intermediary metabolism

Amino sugars

IDP00324
(show subtarget assignments)

1

cloned

Cj1366c

15792689

glmS

D-fructose-6-phosphate amidotransferase ...

598

Drug Target Function

Phase 2: March 2008

1JXA

41.3%

Campylobacter jejuni

Unclassified

IDP90884
(show subtarget assignments)

8

purified

VC1296

15641309

phosphomethylpyrimidine kinase [Vibrio c...

282

Predicted Essential

Community Requests

1JXH

43.6%

Vibrio cholerae

IDP01956
(show subtarget assignments)

1

cloned

STM2061

16765391

sbmC

DNA gyrase inhibitor [Salmonella typhimu...

155

Conserved; Drug target homolg; Drug target functions

Phase 3: June 2008

1JYH

71%

Salmonella enterica

Unknown function

General

IDP90930
(show subtarget assignments)

8

cloned

YPO3384

16123533

mtn

5'-methylthioadenosine/S-adenosylhomocys...

233

Predicted Essential

Community Requests

1JYS

74.7%

Yersinia pestis

IDP02103
(show subtarget assignments)

1

expressed

YPO0891

16121196

dsbC

thiol:disulfide interchange protein DsbC...

238

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 3: June 2008

1JZD

61.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP01458
(show subtarget assignments)

1

soluble

VC2418

15642415

thiol:disulfide interchange protein DsbC...

250

Drug Target Function

Phase 2: March 2008

1JZD

38.4%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP04527
(show subtarget assignments)

1

cloned

STM1824_1_454

16765165

pabB

para-aminobenzoate synthase component I ...

454

Salmonella essential protein

Phase 4: April 2009

1K0E

76.2%

Salmonella enterica

IDP90779
(show subtarget assignments)

8

cloned

YPO3497

16123643

nusA

transcription elongation factor NusA [Ye...

495

Predicted Essential

Community Requests

1K0R

24.4%

Yersinia pestis

IDP90106
(show subtarget assignments)

8

cloned

MPXV_ZAI1979_005_011

68449085

secreted epidermal growth factor-like pr...

142

similar to VACV-COP-C11R, MPXV-ZAI96-D3R

Community Requests

1K36

16.2%

Monkeypox virus

IDP90175
(show subtarget assignments)

8

expressed

AAM13468.1

20153007

VGF

CPXV021 protein or CPXV VGF protein

139

Community Requests

1K36

15.8%

Cowpox virus

host range protein

0

IDP04280
(show subtarget assignments)

1

purified

YPO1108

115346887

gltA

citrate synthase GltA [Yersinia pestis C...

426

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1K3P

86.6%

Yersinia pestis

Energy metabolism

TCA cycle

IDP91458
(show subtarget assignments)

8

soluble

VV1_0162

27363645

gltA

type II citrate synthase [Vibrio vulnifi...

429

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1K3P

75.5%

Vibrio vulnificus

IDP04306
(show subtarget assignments)

8

selected

CAC05809

12329078

ipgE

IpgE, cytoplasmic chaperone for IpgD [Sh...

120

Shigella effector protein

Community Requests

1K3S

27.5%

Shigella flexneri

IDP90767
(show subtarget assignments)

8

soluble

YPO2607

16122820

nadD

nicotinic acid mononucleotide adenylyltr...

220

Predicted Essential

Community Requests

1K4K

56.4%

Yersinia pestis

IDP00932
(show subtarget assignments)

1

purified

STM0645

16764022

nadD

nicotinic acid mononucleotide adenyltran...

213

Conserved Gene / Pathway

Phase 2: March 2008

1K4K

85.4%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00914
(show subtarget assignments)

1

soluble

STM0220

16763610

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

398

Conserved Gene / Pathway

Phase 2: March 2008

1K5H

88.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04402
(show subtarget assignments)

1

cloned

VC2254

15642252

1-deoxy-D-xylulose 5-phosphate reductois...

402

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K5H

60.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00997
(show subtarget assignments)

1

soluble

STM2314

16765641

putative chemotaxis signal transduction ...

333

Conserved Gene / Pathway

Phase 2: March 2008

1K68

12%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP90730
(show subtarget assignments)

8

purified

Cj1598

15792903

hisD

histidinol dehydrogenase [Campylobacter ...

428

Predicted Essential

Community Requests

1K75

59.8%

Campylobacter jejuni

IDP01913
(show subtarget assignments)

1

cloned

GBAA1426

47526698

hisD

histidinol dehydrogenase [Bacillus anthr...

429

Conserved; Drug target functions

Phase 3: June 2008

1K75

39.2%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02636
(show subtarget assignments)

1

expressed

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04641
(show subtarget assignments)

1

purified

FTT0693c

56707813

mutM

formamidopyrimidine-DNA glycosylase [Fra...

274

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1K82

43.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP05771
(show subtarget assignments)

1

cloned

Z0339

12513053

alpha replication protein of prophage CP...

777

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1KA8

9.5%

Escherichia coli

Mobile and extrachromosomal element functions: Prophage functions

IDP04502
(show subtarget assignments)

1

purified

VC1136

9655608

amidotransferase HisH [Vibrio cholerae O...

203

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KA9

36.9%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP02271
(show subtarget assignments)

1

purified

FTT1155c

56708226

aroK

shikimate kinase I [Francisella tularens...

176

Conserved; Drug target functions

Phase 3: June 2008

1KAG

58%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP04177
(show subtarget assignments)

1

purified

VC2629

9657219

shikimate kinase [Vibrio cholerae O1 bio...

174

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KAG

81%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP05299
(show subtarget assignments)

1

soluble

CD2524

126700141

nadD

nicotinate-nucleotide adenylyltransferas...

229

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KAM

34.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP90518
(show subtarget assignments)

8

purified

Cj1404

15792722

hypothetical protein Cj1404 [Campylobact...

181

Predicted Essential

Community Requests

1KAM

30.2%

Campylobacter jejuni

IDP90837
(show subtarget assignments)

8

selected

S2226

30063491

rfbD

dTDP-4-dehydrorhamnose reductase [Shigel...

299

Predicted Essential

Community Requests

1KBZ

85.6%

Shigella flexneri

IDP90561
(show subtarget assignments)

8

cloned

YPO1391

16121671

cmk

cytidylate kinase [Yersinia pestis CO92]...

230

Predicted Essential

Community Requests

1KDO

83%

Yersinia pestis

IDP00048
(show subtarget assignments)

1

cloned

BA_3330

30257875

beta-lactam antibiotic acylase family pr...

796

Virulence

Phase 1: October 2007

1KEH

22.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01752
(show subtarget assignments)

1

selected

GBAA5282

47778383

nprB

neutral protease B [Bacillus anthracis s...

547

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1KEI

31.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02190
(show subtarget assignments)

1

expressed

YPO0360

16120695

frdA

fumarate reductase flavoprotein subunit ...

607

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1KF6

85.2%

Yersinia pestis

Energy metabolism

Anaerobic

IDP00546
(show subtarget assignments)

1

expressed

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP01474
(show subtarget assignments)

1

expressed

VC2657

15642652

fumarate reductase iron-sulfur subunit

252

Conserved Gene / Pathway

Phase 2: March 2008

1KF6

69%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP02619
(show subtarget assignments)

1

cloned

GBAA1372

47526645

nrdF

ribonucleotide-diphosphate reductase sub...

322

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1KGN

44.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP01785
(show subtarget assignments)

1

expressed

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02231
(show subtarget assignments)

1

purified

lmo1377

16803417

lisR

two-component response regulator [Lister...

226

Known virulence-Regulation; Predicted virulence-Resistance to antibiotics and to...

Phase 3: June 2008

1KGS

41.4%

Listeria monocytogenes

Regulatory functions

Other

IDP91359
(show subtarget assignments)

8

purified

VV1_2847

27366129

response regulator [Vibrio vulnificus CM...

219

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1KGS

41.1%

Vibrio vulnificus

IDP91233
(show subtarget assignments)

8

selected

NT04EC1775

26107994

trpD

Anthranilate synthase component II [Esch...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP04161
(show subtarget assignments)

1

cloned

VC1172

9655648

anthranilate phosphoribosyltransferase [...

353

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KGZ

59.5%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP91301
(show subtarget assignments)

8

selected

STM1724

16765068

trpD

anthranilate phosphoribosyltransferase

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.1%

Salmonella enterica

IDP91240
(show subtarget assignments)

8

selected

HP1280

0

335

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

39.4%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP91224
(show subtarget assignments)

8

selected

SF1266

24112662

trpD

bifunctional glutamine amidotransferase/...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

46.7%

Shigella flexneri

IDP91288
(show subtarget assignments)

8

selected

SPA1153

56413351

trpD

bifunctional glutamine amidotransferase/...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Salmonella enterica

IDP00054
(show subtarget assignments)

1

crystallized

BA_3600

30258128

acetyltransferase, CYSE/LACA/LPXA/NODL f...

185

Virulence

Phase 1: October 2007

1KHR

42.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02750
(show subtarget assignments)

1

cloned

GBAA5389

47530699

transferase hexapeptide domain-containin...

170

Conserved; Essential; Drug target functions

Phase 3: June 2008

1KHR

28.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP00043
(show subtarget assignments)

1

purified

BA_2629

30257246

acetyltransferase, CYSE/LACA/LPXA/NODL f...

210

Virulence

Phase 1: October 2007

1KHR

59.5%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91546
(show subtarget assignments)

8

selected

AAA26683

398085

vat

acetyltransferase [Staphylococcus aureus...

219

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KHR

57.5%

Staphylococcus aureus

IDP91687
(show subtarget assignments)

8

selected

NP_000292

4505881

PLG

plasminogen isoform 1 precursor [Homo sa...

810

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1KI0

31.1%

Homo sapiens

IDP04404
(show subtarget assignments)

1

cloned

VC2602

15642597

adenylosuccinate synthetase [Vibrio chol...

432

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KJX

75.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01954
(show subtarget assignments)

1

purified

Cj0812

15792150

thrC

threonine synthase [Campylobacter jejuni...

470

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1KL7

33.2%

Campylobacter jejuni

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90816
(show subtarget assignments)

8

soluble

YPO2878

16123070

hisS

histidyl-tRNA synthetase [Yersinia pesti...

424

Predicted Essential

Community Requests

1KMM

82.1%

Yersinia pestis

IDP90628
(show subtarget assignments)

8

purified

VC0760

15640779

hisS

histidyl-tRNA synthetase [Vibrio cholera...

422

Predicted Essential

Community Requests

1KMM

74.5%

Vibrio cholerae

IDP00434
(show subtarget assignments)

1

cloned

YPO0796

16121108

lysA

diaminopimelate decarboxylase

420

Drug Target Function

Phase 2: March 2008

1KNW

76.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01126
(show subtarget assignments)

1

cloned

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00931
(show subtarget assignments)

1

expressed

STM0615

16763992

ybdR

putative dehydrogenase

412

Essential Gene

Phase 2: March 2008

1KOL

32.5%

Salmonella enterica

Central intermediary metabolism

Other

IDP04681
(show subtarget assignments)

1

soluble

GBAA3131

47528422

adhB

alcohol dehydrogenase, zinc-containing [...

377

virulence factor; putative drug target function;

Phase 4: April 2009

1KOL

31.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP91011
(show subtarget assignments)

8

soluble

y2255

22126141

hypothetical protein y2255 [Yersinia pes...

251

other biological interest / possibly involved in quorum sensing

Community Requests

1KON

83.3%

Yersinia pestis

IDP91710
(show subtarget assignments)

8

selected

NP_006353

15487670

NXF1

nuclear RNA export factor 1 isoform 1 [H...

619

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1KOO

44.6%

Homo sapiens

IDP00962
(show subtarget assignments)

1

cloned

STM1427

16764775

cfa

cyclopropane fatty acyl phospholipid syn...

382

Drug Target Function

Phase 2: March 2008

1KP9

26.7%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP05651
(show subtarget assignments)

1

soluble

Cj1183c

6968610

cfa

guanylate kinase [Campylobacter jejuni s...

387

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1KP9

27.9%

Campylobacter jejuni

Fatty acid and phospholipid metabolism: Biosynthesis

IDP01412
(show subtarget assignments)

1

soluble

VC1122

15641135

cyclopropane-fatty-acyl-phospholipid syn...

432

Drug Target Function

Phase 2: March 2008

1KPI

18.7%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00228
(show subtarget assignments)

1

cloned

YPO3388

16123537

-

putative chloride channel protein

441

Virulence

Phase 1: October 2007

1KPL

76.6%

Yersinia pestis

Transcription

Transcription factors

IDP00928
(show subtarget assignments)

1

purified

STM0602

16763979

ybdH

putative glycerol dehydrogenase

362

Conserved Gene / Pathway

Phase 2: March 2008

1KQ3

31.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP04303
(show subtarget assignments)

1

cloned

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP00543
(show subtarget assignments)

1

soluble

YPO4057

16124173

fdoH

formate dehydrogenase-O, iron-sulfur sub...

323

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

70.9%

Yersinia pestis

Energy metabolism

Anaerobic

IDP01518
(show subtarget assignments)

1

soluble

VC1512

15641521

formate dehydrogenase, iron-sulfur subun...

202

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

29%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP02074
(show subtarget assignments)

1

cloned

STM3149

16766449

hybA

hydrogenase 2 protein HybA [Salmonella t...

328

Conserved; Drug target functions

Phase 3: June 2008

1KQF

29.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01841
(show subtarget assignments)

1

purified

STM2549

16765869

asrB

anaerobic sulfite reductase subunit B [S...

272

Conserved; Drug target functions

Phase 3: June 2008

1KRH

18.8%

Salmonella enterica

Energy metabolism

Anaerobic

IDP91897
(show subtarget assignments)

8

selected

SpneCM_010100007685

298255467

oxidoreductase, NAD-binding protein [Str...

396

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1KRH

13.4%

Streptococcus pneumoniae

IDP04140
(show subtarget assignments)

1

cloned

YPO3116

115348760

ascD

cdp-6-deoxy-delta-3,4-glucoseen reductas...

329

virulence factor; putative drug target function;

Phase 4: April 2009

1KRH

26.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04504
(show subtarget assignments)

1

cloned

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01335
(show subtarget assignments)

1

soluble

VC1144

15641157

clpA

ATP-dependent Clp protease ATP-binding s...

756

Drug Target Function

Phase 2: March 2008

1KSF

77.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91360
(show subtarget assignments)

8

cloned

VV1_2843

27366125

16S rRNA uridine-516 pseudouridylate syn...

233

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1KSK

55.4%

Vibrio vulnificus

IDP90285
(show subtarget assignments)

8

selected

TGME49_083850

211966798

peptidyl-prolyl isomerase, putative [Tox...

521

The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...

Community Requests

1KT0

23.2%

Toxoplasma gondii

IDP90347
(show subtarget assignments)

8

soluble

CT205

15604925

pfkA_1

diphosphate--fructose-6-phosphate 1-phos...

553

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KZH

36.9%

Chlamydia trachomatis

IDP90507
(show subtarget assignments)

8

soluble

VC2270

15642268

riboflavin synthase subunit alpha [Vibri...

217

Predicted Essential

Community Requests

1KZL

35.5%

Vibrio cholerae

IDP90684
(show subtarget assignments)

8

purified

Cj1218c

15792542

ribA

riboflavin synthase subunit alpha [Campy...

203

Predicted Essential

Community Requests

1KZL

29.6%

Campylobacter jejuni

IDP02186
(show subtarget assignments)

1

soluble

FTT1672

56708682

ribB

riboflavin synthase subunit alpha [Franc...

201

Conserved; Drug target functions

Phase 3: June 2008

1KZL

35.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05517
(show subtarget assignments)

1

soluble

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01025
(show subtarget assignments)

1

cloned

STM1196

16764551

acpP

acyl carrier protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1L0H

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis