Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00065 (show subtarget assignments)	1	expressed	BA_5409	30259882		macrolide efflux pump, putative	544	Virulence	Phase 1: October 2007	1YQT	24.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP02702 (show subtarget assignments)	1	cloned	GBAA3442	47528726		neutral protease [Bacillus anthracis str...	565	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	1FJ3	24.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04660 (show subtarget assignments)	1	expressed	GBAA0286	47777799		sensor histidine kinase, putative [Bacil...	314	putative drug target function;	Phase 4: April 2009	2C2A	24.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01495 (show subtarget assignments)	1	cloned	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01107 (show subtarget assignments)	1	soluble	BA_2250	30256894		heat shock protein, Hsp20 family	153	Conserved Gene / Pathway	Phase 2: March 2008	3AAB	24.2%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP91259 (show subtarget assignments)	8	selected	NT02SA1746	14247541	ribA	riboflavin biosynthesis protein [Staphyl...	393	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MGZ	24.2%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01395 (show subtarget assignments)	1	soluble	VC0704	15640723		spermidine/putrescine ABC transporter, p...	359	Conserved Gene / Pathway	Phase 2: March 2008	1A99	24.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP05103 (show subtarget assignments)	1	cloned	CD1226	126698822		putative exported aminodeoxychorismate l...	359	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2R1F	24.2%	Clostridium difficile	Hypothetical proteins: Conserved

IDP05622 (show subtarget assignments)	1	expressed	CD0999	126698583		ABC transporter, substrate-binding lipop...	331	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HN0	24.2%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02316 (show subtarget assignments)	1	soluble	FTT0037	56707217	nuoG	NADH dehydrogenase subunit G [Francisell...	788	Conserved; Drug target functions	Phase 3: June 2008	2FUG	24.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP90879 (show subtarget assignments)	8	expressed	YPO0909	16121214	ubiH	2-octaprenyl-6-methoxyphenyl hydroxylase...	392	Predicted Essential	Community Requests	2X3N	24.2%	Yersinia pestis

IDP91769 (show subtarget assignments)	8	soluble	YPTB1890	51596222	yjcK	ribosomal-protein-alanine acetyltransfer...	185	drug resistance; innate immunity / Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...	Community Requests	3R95	24.3%	Yersinia pseudotuberculosis

IDP02306 (show subtarget assignments)	1	cloned	Cj0079c	15791469	cdtA	cytolethal distending toxin [Campylobact...	268	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	24.3%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP00443 (show subtarget assignments)	1	soluble	YPO0908	16121213	visC	hypothetical protein YPO0908	406	Drug Target Function	Phase 2: March 2008	2R0C	24.3%	Yersinia pestis	Unknown function	General

IDP04089 (show subtarget assignments)	1	expressed	STM1952_1_222	16765290	yecS	putative ABC-type amino acid transporter...	222	Salmonella essential protein	Phase 4: April 2009	2R6G	24.3%	Salmonella enterica

IDP90992 (show subtarget assignments)	8	cloned	y1333	22125232		DNA-binding transcriptional regulator Is...	185	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	3LWF	24.3%	Yersinia pestis

IDP05417 (show subtarget assignments)	1	purified	BA_4788	30259274		conserved domain protein [Bacillus anthr...	152	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K78	24.3%	Bacillus anthracis	Hypothetical proteins: Domain

IDP05192 (show subtarget assignments)	1	cloned	CD0332	126697904	bclA1	putative exosporium glycoprotein [Clostr...	693	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	24.4%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP01604 (show subtarget assignments)	1	purified	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	1Z47	24.4%	Coxiella burnetii	Transport and binding proteins	Other

IDP05632 (show subtarget assignments)	1	cloned	CD1898	126699508		putative phage-related cell wall hydrola...	262	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QAY	24.4%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP05708 (show subtarget assignments)	1	cloned	lmo2839	16804876	-	hypothetical protein lmo2839 [Listeria m...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3QUF	24.4%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP02482 (show subtarget assignments)	1	expressed	CBU_1857	29542411	oppD	peptide ABC transporter, ATP-binding pro...	530	Conserved; Drug target functions	Phase 3: June 2008	3PIH	24.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01683 (show subtarget assignments)	1	expressed	GBAA0187	47525446		oligopeptide ABC transporter, ATP-bindin...	336	Conserved; Drug target functions	Phase 3: June 2008	2ONK	24.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP90779 (show subtarget assignments)	8	cloned	YPO3497	16123643	nusA	transcription elongation factor NusA [Ye...	495	Predicted Essential	Community Requests	1K0R	24.4%	Yersinia pestis

IDP02617 (show subtarget assignments)	1	expressed	GBAA1286	47526551		D-alanyl-D-alanine carboxypeptidase fami...	428	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3MFD	24.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02586 (show subtarget assignments)	1	cloned	Cj1478c	15792793	cadF	fibronectin-binding protein [Campylobact...	319	Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...	Phase 3: June 2008	3NB3	24.5%	Campylobacter jejuni	Cell envelope	Other

IDP00001 (show subtarget assignments)	1	cloned	BA_4599	30259099		aldehyde-alcohol dehydrogenase	867	Drug Target Homolog	Phase 1: October 2007	3MY7	24.5%	Bacillus anthracis	Energy metabolism	Fermentation

IDP00464 (show subtarget assignments)	1	purified	YPO2522	16122741		hypothetical protein YPO2522	319	Drug Target Function	Phase 2: March 2008	1V8G	24.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05551 (show subtarget assignments)	1	cloned	CD3049	126700667		putative PTS system, IIB component [Clos...	102	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2L2Q	24.5%	Clostridium difficile	Signal transduction: PTS

IDP01390 (show subtarget assignments)	1	soluble	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90289 (show subtarget assignments)	8	purified	TGME49_094270	211967870		arginine methyltransferase protein, puta...	660	Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...	Community Requests	2Y1W	24.5%	Toxoplasma gondii

IDP05564 (show subtarget assignments)	1	cloned	lmo2431	16804469	-	hypothetical protein lmo2431 [Listeria m...	323	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Q8P	24.5%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP00839 (show subtarget assignments)	1	soluble	SACOL1328	57284485	glnR	glutamine synthetase repressor	122	Conserved Gene / Pathway	Phase 2: March 2008	3HH0	24.6%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02197 (show subtarget assignments)	1	cloned	YPO0405	16120739		putative phosphoenolpyruvate-protein pho...	852	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2KX9	24.6%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02455 (show subtarget assignments)	1	expressed	GBAA3813	47529098		prophage LambdaBa01, thymidylate synthas...	252	Conserved; Drug target functions	Phase 3: June 2008	3AH5	24.6%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP05165 (show subtarget assignments)	1	soluble	BA_1888	30256549		enterotoxin [Bacillus anthracis str. Ame...	402	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NRJ	24.6%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP01017 (show subtarget assignments)	1	expressed	STM2854	16766160	hypA	hydrogenase nickel incorporation protein...	118	Conserved Gene / Pathway	Phase 2: March 2008	3A43	24.6%	Salmonella enterica	Protein fate	Protein modification and repair

IDP02207 (show subtarget assignments)	1	expressed	YPO0612	16120938		putative sugar binding protein [Yersinia...	414	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QUF	24.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91179 (show subtarget assignments)	8	expressed	y2283	22126168		hypothetical protein y2283 [Yersinia pes...	291	other biological interest / Other biological interest	Community Requests	2PZ0	24.7%	Yersinia pestis

IDP00487 (show subtarget assignments)	1	soluble	YPO1491	16121764		ABC transporter ATP-binding protein	531	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	24.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP05381 (show subtarget assignments)	1	cloned	BA_0711	30254309	gerLC	spore germination protein GerLC [Bacillu...	388	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3N54	24.7%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP02142 (show subtarget assignments)	1	cloned	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP05324 (show subtarget assignments)	1	cloned	CD3431	126701054		putative cobalamin biosynthesis kinase [...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VIS	24.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602 (show subtarget assignments)	1	cloned	Cj1148	15792472	waaF	ADP-heptose--LPS heptosyltransferase II ...	319	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	1PSW	24.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00673 (show subtarget assignments)	1	expressed	SACOL1322	57286057		hydrolase, alpha/beta hydrolase fold fam...	304	Drug Target Function	Phase 2: March 2008	3HJU	24.7%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP02349 (show subtarget assignments)	1	soluble	GBAA5069	47778360		LPXTG-site transpeptidase family protein...	198	Drug target motif; Drug target functions	Phase 3: June 2008	2XWG	24.7%	Bacillus anthracis	Cell envelope	Other

IDP02364 (show subtarget assignments)	1	cloned	Cj0365c	15791732		putative outer membrane channel protein ...	492	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	3PIK	24.8%	Campylobacter jejuni	Cellular processes	Toxin production and resistance

IDP01081 (show subtarget assignments)	1	soluble	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	3LQ7	24.8%	Salmonella enterica	Cellular processes	Detoxification

IDP01159 (show subtarget assignments)	1	soluble	BA_4745	30259235		ABC transporter, ATP-binding protein	294	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	24.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP04394 (show subtarget assignments)	1	cloned	CPF_2117	110800208	spoVD	stage V sporulation protein D [Clostridi...	695	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	24.8%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP91919 (show subtarget assignments)	8	selected	SpneCM_010100003360	298254637		choline binding protein G [Streptococcus...	197	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P3C	24.9%	Streptococcus pneumoniae

IDP91250 (show subtarget assignments)	8	selected	NT01LM1295	16410617	lmo1201	lmo1201 [Listeria monocytogenes]	493	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	24.9%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01346 (show subtarget assignments)	1	cloned	VC1621	15641628		agglutination protein	445	Conserved Gene / Pathway	Phase 2: March 2008	2VDD	24.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP05372 (show subtarget assignments)	1	cloned	BA_0397	30253932		LPXTG-motif cell wall anchor domain prot...	257	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GHG	24.9%	Bacillus anthracis	Cell envelope: Other

IDP01972 (show subtarget assignments)	1	cloned	CBU_0841	29541435		glycosyl transferase, group 1 family pro...	377	Conserved; Drug target functions	Phase 3: June 2008	2GEJ	24.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90571 (show subtarget assignments)	8	expressed	YPO0416	16120749		putative lipopolysaccharide core biosynt...	346	Predicted Essential	Community Requests	3TOV	24.9%	Yersinia pestis

IDP91265 (show subtarget assignments)	8	selected	NT05BA1551	49178367		2-heptaprenyl-1,4-naphthoquinone methylt...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VE3	24.9%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP91292 (show subtarget assignments)	8	selected	SPA2526	56414632	pheA	bifunctional chorismate mutase/prephenat...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	24.9%	Salmonella enterica

IDP02258 (show subtarget assignments)	1	cloned	Cj0178	15791565		putative outer membrane siderophore rece...	755	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3CSL	24.9%	Campylobacter jejuni	Cell envelope	Other

IDP00574 (show subtarget assignments)	1	cloned	YPO0531	16120860	leuC	isopropylmalate isomerase large subunit ...	476	Virulence Associated Factor	Phase 2: March 2008	1ACO	25%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP02351 (show subtarget assignments)	1	cloned	FTT1112c	56708190	rpoH	RNA polymerase factor sigma-32 [Francise...	292	Drug Target	Phase 3: June 2008	1IW7	25%	Francisella tularensis	Cellular processesTranscription	Adaptations to atypical conditionsTranscription factors

IDP00431 (show subtarget assignments)	1	selected	YPO3720	16123858	shlB	hemolysin activator protein	561	Virulence Associated Factor	Phase 2: March 2008	2QDZ	25%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP00737 (show subtarget assignments)	1	expressed	SACOL0993	57284367	oppD	oligopeptide ABC transporter, ATP-bindin...	360	Drug Target Function	Phase 2: March 2008	1B0U	25%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP04480 (show subtarget assignments)	1	selected	YPO3104	218930142	wbyK	putative mannosyltransferase [Yersinia p...	337	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	2BIS	25.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02339 (show subtarget assignments)	1	expressed	YPO2647	16122856	proV	glycine betaine/L-proline transport ATP-...	399	CD; Drug target functions	Phase 3: June 2008	3FVQ	25.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP05692 (show subtarget assignments)	1	soluble	lmo1916	16803955	-	hypothetical protein lmo1916 [Listeria m...	335	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2QMI	25.1%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP01214 (show subtarget assignments)	1	purified	BA_3460	30257999	cfa	cyclopropane-fatty-acyl-phospholipid syn...	390	Drug Target Function	Phase 2: March 2008	1TPY	25.1%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01366 (show subtarget assignments)	1	soluble	VC0202	15640232		iron(III) ABC transporter, periplasmic i...	319	Conserved Gene / Pathway	Phase 2: March 2008	1EFD	25.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01076 (show subtarget assignments)	8	expressed	STM4120	16767385	argE	acetylornithine deacetylase	383	Drug Target Function	Community Requests	3CT9	25.1%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP90251 (show subtarget assignments)	8	expressed	SF4034	56480493	argE	acetylornithine deacetylase [Shigella fl...	383	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2F7V	25.1%	Shigella flexneri

IDP01049 (show subtarget assignments)	1	purified	STM3183	16766483	icc	cyclic 3',5'-adenosine monophosphate pho...	275	Conserved Gene / Pathway	Phase 2: March 2008	2HY1	25.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP01800 (show subtarget assignments)	1	soluble	GBAA1129	47526399		S-layer protein, putative [Bacillus anth...	219	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.1%	Bacillus anthracis	Cell envelope	Surface structures

IDP05114 (show subtarget assignments)	1	cloned	CD2537	126700154		putative membrane-associated 5'-nucleoti...	605	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IVD	25.1%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP91304 (show subtarget assignments)	8	selected	STM2667	16765982	pheA	chorismate mutase P/prephenate dehydrata...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	25.1%	Salmonella enterica

IDP04670 (show subtarget assignments)	1	expressed	GBAA1356	47526628	kinB-1	sporulation kinase B [Bacillus anthracis...	402	putative drug target function;	Phase 4: April 2009	3D36	25.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05308 (show subtarget assignments)	1	soluble	CD3420	126701043	hemD	porphyrin biosynthesis protein [Clostrid...	499	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PJQ	25.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00615 (show subtarget assignments)	1	expressed	SACOL1160	57284445	sdhB	succinate dehydrogenase iron-sulfur subu...	271	Conserved Gene / Pathway	Phase 2: March 2008	1E7P	25.1%	Staphylococcus aureus	Energy metabolism	TCA cycle

IDP90338 (show subtarget assignments)	8	cloned	CT087	15604806	malQ	4-alpha-glucanotransferase [Chlamydia tr...	527	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2X1I	25.2%	Chlamydia trachomatis

IDP01798 (show subtarget assignments)	1	cloned	GBAA1130	47526400		S-layer protein, putative [Bacillus anth...	218	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	25.2%	Bacillus anthracis	Cell envelope	Surface structures

IDP00104 (show subtarget assignments)	1	purified	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05201 (show subtarget assignments)	1	cloned	CD1698	126699304	ribA	riboflavin biosynthesis protein [Clostri...	408	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MGZ	25.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP90803 (show subtarget assignments)	8	selected	YPO0055	16120408	kdtA	3-deoxy-D-manno-octulosonic-acid transfe...	425	Predicted Essential	Community Requests	2XCI	25.2%	Yersinia pestis

IDP05624 (show subtarget assignments)	1	cloned	CD1146	126698741	mreC	putative rod shape-determining protein [...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J5U	25.3%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02430 (show subtarget assignments)	1	expressed	FTT1151c	56708222		hypothetical protein FTT1151c [Francisel...	95	Drug Target	Phase 3: June 2008	2JR5	25.3%	Francisella tularensis	Unknown function	General

IDP01190 (show subtarget assignments)	1	cloned	BA_0872	30254622		N-acetylmuramoyl-L-alanine amidase, fami...	348	Drug Target Function	Phase 2: March 2008	3HMB	25.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00757 (show subtarget assignments)	1	soluble	SACOL0135	57285338		alcohol dehydrogenase, iron-containing	869	Conserved Gene / Pathway	Phase 2: March 2008	3MY7	25.3%	Staphylococcus aureus	Energy metabolism	Fermentation

IDP04248 (show subtarget assignments)	1	soluble	CPF_1477	110800354		ABC transporter, substrate-binding prote...	348	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A99	25.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP05531 (show subtarget assignments)	1	cloned	CD2770	126700386		putative capsular polysaccharide biosynt...	363	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3C48	25.3%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00320 (show subtarget assignments)	1	expressed	CBU_0550	29653890	pbpA	penicillin-binding protein 2	612	Drug Target Function	Phase 2: March 2008	1MWR	25.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01513 (show subtarget assignments)	1	purified	VC1312	161582006	alr	alanine racemase	407	Conserved Gene / Pathway	Phase 2: March 2008	1BD0	25.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05723 (show subtarget assignments)	1	expressed	BA_3001	30257589		alkaline phosphatase [Bacillus anthracis...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A52	25.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP91940 (show subtarget assignments)	8	selected	SpneCM_010100006879	298255307		ABC transporter, ATP-binding protein [St...	538	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	25.4%	Streptococcus pneumoniae

IDP01673 (show subtarget assignments)	1	soluble	GBAA5206	47530513		M23/37 family peptidase [Bacillus anthra...	327	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	3SLU	25.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91216 (show subtarget assignments)	1	purified	FTT_1275	56708335	mglA	macrophage growth locus, subunit A [Fran...	205	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MDK	25.4%	Francisella tularensis

IDP91571 (show subtarget assignments)	8	expressed	BAB35251	13361293	ECs1828	hypothetical protein [Escherichia coli O...	169	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	25.4%	Escherichia coli

IDP01660 (show subtarget assignments)	1	expressed	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04162 (show subtarget assignments)	1	expressed	VC1190	15641203	hemH	phosphoribosylaminoimidazole-succinocarb...	405	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3R9R	25.4%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05268 (show subtarget assignments)	1	cloned	lmo0366	16802411	-	hypothetical protein lmo0366 [Listeria m...	386	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3AT7	25.4%	Listeria monocytogenes	Cell envelope: Other

IDP05038 (show subtarget assignments)	1	cloned	BA_1902	30256562		multicopper oxidase family protein [Baci...	551	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PPS	25.4%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP02521 (show subtarget assignments)	1	soluble	Cj1146c	15792471	waaV	lipooligosaccharide biosynthesis glycosy...	274	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	25.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00065
(show subtarget assignments)

1

expressed

BA_5409

30259882

macrolide efflux pump, putative

544

Virulence

Phase 1: October 2007

1YQT

24.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP02702
(show subtarget assignments)

1

cloned

GBAA3442

47528726

neutral protease [Bacillus anthracis str...

565

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

1FJ3

24.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04660
(show subtarget assignments)

1

expressed

GBAA0286

47777799

sensor histidine kinase, putative [Bacil...

314

putative drug target function;

Phase 4: April 2009

2C2A

24.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01495
(show subtarget assignments)

1

cloned

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01107
(show subtarget assignments)

1

soluble

BA_2250

30256894

heat shock protein, Hsp20 family

153

Conserved Gene / Pathway

Phase 2: March 2008

3AAB

24.2%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP91259
(show subtarget assignments)

8

selected

NT02SA1746

14247541

ribA

riboflavin biosynthesis protein [Staphyl...

393

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MGZ

24.2%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP01395
(show subtarget assignments)

1

soluble

VC0704

15640723

spermidine/putrescine ABC transporter, p...

359

Conserved Gene / Pathway

Phase 2: March 2008

1A99

24.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP05103
(show subtarget assignments)

1

cloned

CD1226

126698822

putative exported aminodeoxychorismate l...

359

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2R1F

24.2%

Clostridium difficile

Hypothetical proteins: Conserved

IDP05622
(show subtarget assignments)

1

expressed

CD0999

126698583

ABC transporter, substrate-binding lipop...

331

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HN0

24.2%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02316
(show subtarget assignments)

1

soluble

FTT0037

56707217

nuoG

NADH dehydrogenase subunit G [Francisell...

788

Conserved; Drug target functions

Phase 3: June 2008

2FUG

24.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP90879
(show subtarget assignments)

8

expressed

YPO0909

16121214

ubiH

2-octaprenyl-6-methoxyphenyl hydroxylase...

392

Predicted Essential

Community Requests

2X3N

24.2%

Yersinia pestis

IDP91769
(show subtarget assignments)

8

soluble

YPTB1890

51596222

yjcK

ribosomal-protein-alanine acetyltransfer...

185

drug resistance; innate immunity / Yersinia pseudotuberculosis YjcK (MccE-ctd homolog) - Yersinia pseudotuberculosi...

Community Requests

3R95

24.3%

Yersinia pseudotuberculosis

IDP02306
(show subtarget assignments)

1

cloned

Cj0079c

15791469

cdtA

cytolethal distending toxin [Campylobact...

268

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

24.3%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP00443
(show subtarget assignments)

1

soluble

YPO0908

16121213

visC

hypothetical protein YPO0908

406

Drug Target Function

Phase 2: March 2008

2R0C

24.3%

Yersinia pestis

Unknown function

General

IDP04089
(show subtarget assignments)

1

expressed

STM1952_1_222

16765290

yecS

putative ABC-type amino acid transporter...

222

Salmonella essential protein

Phase 4: April 2009

2R6G

24.3%

Salmonella enterica

IDP90992
(show subtarget assignments)

8

cloned

y1333

22125232

DNA-binding transcriptional regulator Is...

185

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

3LWF

24.3%

Yersinia pestis

IDP05417
(show subtarget assignments)

1

purified

BA_4788

30259274

conserved domain protein [Bacillus anthr...

152

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K78

24.3%

Bacillus anthracis

Hypothetical proteins: Domain

IDP05192
(show subtarget assignments)

1

cloned

CD0332

126697904

bclA1

putative exosporium glycoprotein [Clostr...

693

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

24.4%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP01604
(show subtarget assignments)

1

purified

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

1Z47

24.4%

Coxiella burnetii

Transport and binding proteins

Other

IDP05632
(show subtarget assignments)

1

cloned

CD1898

126699508

putative phage-related cell wall hydrola...

262

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QAY

24.4%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP05708
(show subtarget assignments)

1

cloned

lmo2839

16804876

-

hypothetical protein lmo2839 [Listeria m...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3QUF

24.4%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP02482
(show subtarget assignments)

1

expressed

CBU_1857

29542411

oppD

peptide ABC transporter, ATP-binding pro...

530

Conserved; Drug target functions

Phase 3: June 2008

3PIH

24.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01683
(show subtarget assignments)

1

expressed

GBAA0187

47525446

oligopeptide ABC transporter, ATP-bindin...

336

Conserved; Drug target functions

Phase 3: June 2008

2ONK

24.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP90779
(show subtarget assignments)

8

cloned

YPO3497

16123643

nusA

transcription elongation factor NusA [Ye...

495

Predicted Essential

Community Requests

1K0R

24.4%

Yersinia pestis

IDP02617
(show subtarget assignments)

1

expressed

GBAA1286

47526551

D-alanyl-D-alanine carboxypeptidase fami...

428

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3MFD

24.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02586
(show subtarget assignments)

1

cloned

Cj1478c

15792793

cadF

fibronectin-binding protein [Campylobact...

319

Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...

Phase 3: June 2008

3NB3

24.5%

Campylobacter jejuni

Cell envelope

Other

IDP00001
(show subtarget assignments)

1

cloned

BA_4599

30259099

aldehyde-alcohol dehydrogenase

867

Drug Target Homolog

Phase 1: October 2007

3MY7

24.5%

Bacillus anthracis

Energy metabolism

Fermentation

IDP00464
(show subtarget assignments)

1

purified

YPO2522

16122741

hypothetical protein YPO2522

319

Drug Target Function

Phase 2: March 2008

1V8G

24.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05551
(show subtarget assignments)

1

cloned

CD3049

126700667

putative PTS system, IIB component [Clos...

102

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2L2Q

24.5%

Clostridium difficile

Signal transduction: PTS

IDP01390
(show subtarget assignments)

1

soluble

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90289
(show subtarget assignments)

8

purified

TGME49_094270

211967870

arginine methyltransferase protein, puta...

660

Epigenetic is an emerging field in Toxoplasma biology that will provide new targ...

Community Requests

2Y1W

24.5%

Toxoplasma gondii

IDP05564
(show subtarget assignments)

1

cloned

lmo2431

16804469

-

hypothetical protein lmo2431 [Listeria m...

323

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Q8P

24.5%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP00839
(show subtarget assignments)

1

soluble

SACOL1328

57284485

glnR

glutamine synthetase repressor

122

Conserved Gene / Pathway

Phase 2: March 2008

3HH0

24.6%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02197
(show subtarget assignments)

1

cloned

YPO0405

16120739

putative phosphoenolpyruvate-protein pho...

852

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2KX9

24.6%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02455
(show subtarget assignments)

1

expressed

GBAA3813

47529098

prophage LambdaBa01, thymidylate synthas...

252

Conserved; Drug target functions

Phase 3: June 2008

3AH5

24.6%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP05165
(show subtarget assignments)

1

soluble

BA_1888

30256549

enterotoxin [Bacillus anthracis str. Ame...

402

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NRJ

24.6%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP01017
(show subtarget assignments)

1

expressed

STM2854

16766160

hypA

hydrogenase nickel incorporation protein...

118

Conserved Gene / Pathway

Phase 2: March 2008

3A43

24.6%

Salmonella enterica

Protein fate

Protein modification and repair

IDP02207
(show subtarget assignments)

1

expressed

YPO0612

16120938

putative sugar binding protein [Yersinia...

414

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QUF

24.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91179
(show subtarget assignments)

8

expressed

y2283

22126168

hypothetical protein y2283 [Yersinia pes...

291

other biological interest / Other biological interest

Community Requests

2PZ0

24.7%

Yersinia pestis

IDP00487
(show subtarget assignments)

1

soluble

YPO1491

16121764

ABC transporter ATP-binding protein

531

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

24.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP05381
(show subtarget assignments)

1

cloned

BA_0711

30254309

gerLC

spore germination protein GerLC [Bacillu...

388

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3N54

24.7%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP02142
(show subtarget assignments)

1

cloned

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP05324
(show subtarget assignments)

1

cloned

CD3431

126701054

putative cobalamin biosynthesis kinase [...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VIS

24.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602
(show subtarget assignments)

1

cloned

Cj1148

15792472

waaF

ADP-heptose--LPS heptosyltransferase II ...

319

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

1PSW

24.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00673
(show subtarget assignments)

1

expressed

SACOL1322

57286057

hydrolase, alpha/beta hydrolase fold fam...

304

Drug Target Function

Phase 2: March 2008

3HJU

24.7%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP02349
(show subtarget assignments)

1

soluble

GBAA5069

47778360

LPXTG-site transpeptidase family protein...

198

Drug target motif; Drug target functions

Phase 3: June 2008

2XWG

24.7%

Bacillus anthracis

Cell envelope

Other

IDP02364
(show subtarget assignments)

1

cloned

Cj0365c

15791732

putative outer membrane channel protein ...

492

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

3PIK

24.8%

Campylobacter jejuni

Cellular processes

Toxin production and resistance

IDP01081
(show subtarget assignments)

1

soluble

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

3LQ7

24.8%

Salmonella enterica

Cellular processes

Detoxification

IDP01159
(show subtarget assignments)

1

soluble

BA_4745

30259235

ABC transporter, ATP-binding protein

294

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

24.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP04394
(show subtarget assignments)

1

cloned

CPF_2117

110800208

spoVD

stage V sporulation protein D [Clostridi...

695

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

24.8%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP91919
(show subtarget assignments)

8

selected

SpneCM_010100003360

298254637

choline binding protein G [Streptococcus...

197

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P3C

24.9%

Streptococcus pneumoniae

IDP91250
(show subtarget assignments)

8

selected

NT01LM1295

16410617

lmo1201

lmo1201 [Listeria monocytogenes]

493

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

24.9%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01346
(show subtarget assignments)

1

cloned

VC1621

15641628

agglutination protein

445

Conserved Gene / Pathway

Phase 2: March 2008

2VDD

24.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05372
(show subtarget assignments)

1

cloned

BA_0397

30253932

LPXTG-motif cell wall anchor domain prot...

257

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GHG

24.9%

Bacillus anthracis

Cell envelope: Other

IDP01972
(show subtarget assignments)

1

cloned

CBU_0841

29541435

glycosyl transferase, group 1 family pro...

377

Conserved; Drug target functions

Phase 3: June 2008

2GEJ

24.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90571
(show subtarget assignments)

8

expressed

YPO0416

16120749

putative lipopolysaccharide core biosynt...

346

Predicted Essential

Community Requests

3TOV

24.9%

Yersinia pestis

IDP91265
(show subtarget assignments)

8

selected

NT05BA1551

49178367

2-heptaprenyl-1,4-naphthoquinone methylt...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VE3

24.9%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP91292
(show subtarget assignments)

8

selected

SPA2526

56414632

pheA

bifunctional chorismate mutase/prephenat...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

24.9%

Salmonella enterica

IDP02258
(show subtarget assignments)

1

cloned

Cj0178

15791565

putative outer membrane siderophore rece...

755

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3CSL

24.9%

Campylobacter jejuni

Cell envelope

Other

IDP00574
(show subtarget assignments)

1

cloned

YPO0531

16120860

leuC

isopropylmalate isomerase large subunit ...

476

Virulence Associated Factor

Phase 2: March 2008

1ACO

25%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP02351
(show subtarget assignments)

1

cloned

FTT1112c

56708190

rpoH

RNA polymerase factor sigma-32 [Francise...

292

Drug Target

Phase 3: June 2008

1IW7

25%

Francisella tularensis

Cellular processesTranscription

Adaptations to atypical conditionsTranscription factors

IDP00431
(show subtarget assignments)

1

selected

YPO3720

16123858

shlB

hemolysin activator protein

561

Virulence Associated Factor

Phase 2: March 2008

2QDZ

25%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP00737
(show subtarget assignments)

1

expressed

SACOL0993

57284367

oppD

oligopeptide ABC transporter, ATP-bindin...

360

Drug Target Function

Phase 2: March 2008

1B0U

25%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP04480
(show subtarget assignments)

1

selected

YPO3104

218930142

wbyK

putative mannosyltransferase [Yersinia p...

337

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

2BIS

25.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02339
(show subtarget assignments)

1

expressed

YPO2647

16122856

proV

glycine betaine/L-proline transport ATP-...

399

CD; Drug target functions

Phase 3: June 2008

3FVQ

25.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP05692
(show subtarget assignments)

1

soluble

lmo1916

16803955

-

hypothetical protein lmo1916 [Listeria m...

335

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2QMI

25.1%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP01214
(show subtarget assignments)

1

purified

BA_3460

30257999

cfa

cyclopropane-fatty-acyl-phospholipid syn...

390

Drug Target Function

Phase 2: March 2008

1TPY

25.1%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01366
(show subtarget assignments)

1

soluble

VC0202

15640232

iron(III) ABC transporter, periplasmic i...

319

Conserved Gene / Pathway

Phase 2: March 2008

1EFD

25.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01076
(show subtarget assignments)

8

expressed

STM4120

16767385

argE

acetylornithine deacetylase

383

Drug Target Function

Community Requests

3CT9

25.1%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP90251
(show subtarget assignments)

8

expressed

SF4034

56480493

argE

acetylornithine deacetylase [Shigella fl...

383

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2F7V

25.1%

Shigella flexneri

IDP01049
(show subtarget assignments)

1

purified

STM3183

16766483

icc

cyclic 3',5'-adenosine monophosphate pho...

275

Conserved Gene / Pathway

Phase 2: March 2008

2HY1

25.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP01800
(show subtarget assignments)

1

soluble

GBAA1129

47526399

S-layer protein, putative [Bacillus anth...

219

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.1%

Bacillus anthracis

Cell envelope

Surface structures

IDP05114
(show subtarget assignments)

1

cloned

CD2537

126700154

putative membrane-associated 5'-nucleoti...

605

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IVD

25.1%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP91304
(show subtarget assignments)

8

selected

STM2667

16765982

pheA

chorismate mutase P/prephenate dehydrata...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

25.1%

Salmonella enterica

IDP04670
(show subtarget assignments)

1

expressed

GBAA1356

47526628

kinB-1

sporulation kinase B [Bacillus anthracis...

402

putative drug target function;

Phase 4: April 2009

3D36

25.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05308
(show subtarget assignments)

1

soluble

CD3420

126701043

hemD

porphyrin biosynthesis protein [Clostrid...

499

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PJQ

25.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP00615
(show subtarget assignments)

1

expressed

SACOL1160

57284445

sdhB

succinate dehydrogenase iron-sulfur subu...

271

Conserved Gene / Pathway

Phase 2: March 2008

1E7P

25.1%

Staphylococcus aureus

Energy metabolism

TCA cycle

IDP90338
(show subtarget assignments)

8

cloned

CT087

15604806

malQ

4-alpha-glucanotransferase [Chlamydia tr...

527

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2X1I

25.2%

Chlamydia trachomatis

IDP01798
(show subtarget assignments)

1

cloned

GBAA1130

47526400

S-layer protein, putative [Bacillus anth...

218

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

25.2%

Bacillus anthracis

Cell envelope

Surface structures

IDP00104
(show subtarget assignments)

1

purified

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05201
(show subtarget assignments)

1

cloned

CD1698

126699304

ribA

riboflavin biosynthesis protein [Clostri...

408

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MGZ

25.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP90803
(show subtarget assignments)

8

selected

YPO0055

16120408

kdtA

3-deoxy-D-manno-octulosonic-acid transfe...

425

Predicted Essential

Community Requests

2XCI

25.2%

Yersinia pestis

IDP05624
(show subtarget assignments)

1

cloned

CD1146

126698741

mreC

putative rod shape-determining protein [...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J5U

25.3%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02430
(show subtarget assignments)

1

expressed

FTT1151c

56708222

hypothetical protein FTT1151c [Francisel...

95

Drug Target

Phase 3: June 2008

2JR5

25.3%

Francisella tularensis

Unknown function

General

IDP01190
(show subtarget assignments)

1

cloned

BA_0872

30254622

N-acetylmuramoyl-L-alanine amidase, fami...

348

Drug Target Function

Phase 2: March 2008

3HMB

25.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00757
(show subtarget assignments)

1

soluble

SACOL0135

57285338

alcohol dehydrogenase, iron-containing

869

Conserved Gene / Pathway

Phase 2: March 2008

3MY7

25.3%

Staphylococcus aureus

Energy metabolism

Fermentation

IDP04248
(show subtarget assignments)

1

soluble

CPF_1477

110800354

ABC transporter, substrate-binding prote...

348

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A99

25.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP05531
(show subtarget assignments)

1

cloned

CD2770

126700386

putative capsular polysaccharide biosynt...

363

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3C48

25.3%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00320
(show subtarget assignments)

1

expressed

CBU_0550

29653890

pbpA

penicillin-binding protein 2

612

Drug Target Function

Phase 2: March 2008

1MWR

25.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01513
(show subtarget assignments)

1

purified

VC1312

161582006

alr

alanine racemase

407

Conserved Gene / Pathway

Phase 2: March 2008

1BD0

25.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05723
(show subtarget assignments)

1

expressed

BA_3001

30257589

alkaline phosphatase [Bacillus anthracis...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A52

25.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP91940
(show subtarget assignments)

8

selected

SpneCM_010100006879

298255307

ABC transporter, ATP-binding protein [St...

538

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

25.4%

Streptococcus pneumoniae

IDP01673
(show subtarget assignments)

1

soluble

GBAA5206

47530513

M23/37 family peptidase [Bacillus anthra...

327

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

3SLU

25.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91216
(show subtarget assignments)

1

purified

FTT_1275

56708335

mglA

macrophage growth locus, subunit A [Fran...

205

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MDK

25.4%

Francisella tularensis

IDP91571
(show subtarget assignments)

8

expressed

BAB35251

13361293

ECs1828

hypothetical protein [Escherichia coli O...

169

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

25.4%

Escherichia coli

IDP01660
(show subtarget assignments)

1

expressed

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04162
(show subtarget assignments)

1

expressed

VC1190

15641203

hemH

phosphoribosylaminoimidazole-succinocarb...

405

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3R9R

25.4%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05268
(show subtarget assignments)

1

cloned

lmo0366

16802411

-

hypothetical protein lmo0366 [Listeria m...

386

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3AT7

25.4%

Listeria monocytogenes

Cell envelope: Other

IDP05038
(show subtarget assignments)

1

cloned

BA_1902

30256562

multicopper oxidase family protein [Baci...

551

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PPS

25.4%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP02521
(show subtarget assignments)

1

soluble

Cj1146c

15792471

waaV

lipooligosaccharide biosynthesis glycosy...

274

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

25.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides