Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90549 (show subtarget assignments)	8	in_pdb 3L92 3L93	YPO0053	16120406	coaD	phosphopantetheine adenylyltransferase [...	159	Predicted Essential	Community Requests	3L92	100%	Yersinia pestis

IDP00331 (show subtarget assignments)	1	in_pdb 3RE3	FTT1128	56708205	ispF	2C-methyl-D-erythritol 2,4-cyclodiphosph...	159	Drug Target Function	Phase 2: March 2008	3RE3	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP91549 (show subtarget assignments)	8	cloned	CPF_1846	110800166		hypothetical protein CPF_1846 [Clostridi...	159	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Clostridium perfringens

IDP00308 (show subtarget assignments)	1	soluble	CBU_0288	29653640	coaD	phosphopantetheine adenylyltransferase	159	Drug Target Function	Phase 2: March 2008	3IKZ	47.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02341 (show subtarget assignments)	1	cloned	FTT1313c	56708370	greA	transcriptional elongation factor [Franc...	160	Conserved; Drug target functions	Phase 3: June 2008	1GRJ	63.1%	Francisella tularensis	Regulatory functions	Other

IDP01668 (show subtarget assignments)	1	soluble	GBAA0060	47525314		hypothetical protein GBAA0060 [Bacillus ...	160	Essential;	Phase 3: June 2008	2K4K	29.4%	Bacillus anthracis	Unknown function	General

IDP91581 (show subtarget assignments)	8	cloned	CBU_0080	29540703		hypothetical protein	160	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP00667 (show subtarget assignments)	1	soluble	SACOL1134	57285920	kdtB	lipopolysaccharide core biosynthesis pro...	160	Conserved Gene / Pathway	Phase 2: March 2008	3F3M	100%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90364 (show subtarget assignments)	8	expressed	CT_083	3328478		hypothetical protein [Chlamydia trachoma...	160	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90544 (show subtarget assignments)	8	in_pdb 3Q1H	YPO0486	16120816	folA	dihydrofolate reductase [Yersinia pestis...	160	Predicted Essential	Community Requests	3Q1H	100%	Yersinia pestis

IDP05592 (show subtarget assignments)	1	cloned	BA_3194	30257761		putative lipoprotein [Bacillus anthracis...	160	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP01034 (show subtarget assignments)	0	work_stopped	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90527 (show subtarget assignments)	8	cloned	YPO3179	16123341	pgpA	phosphatidylglycerophosphatase A [Yersin...	161	Predicted Essential	Community Requests			Yersinia pestis

IDP04141 (show subtarget assignments)	1	in_pdb 3V4H	YPO2937	115348601		conserved hypothetical protein [Yersinia...	161	virulence factor; conserved gene;	Phase 4: April 2009	3V4H	100%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01684 (show subtarget assignments)	1	soluble	YPO3559	16123703		hypothetical protein YPO3559 [Yersinia p...	161	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP02165 (show subtarget assignments)	1	soluble	CBU_1993	29542548	folA	dihydrofolate reductase [Coxiella burnet...	161	Conserved; Drug target functions	Phase 3: June 2008	3TQ8	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP91319 (show subtarget assignments)	8	soluble	VV2_0325	27366768		transcriptional regulator [Vibrio vulnif...	161	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2FBK	28.9%	Vibrio vulnificus

IDP05667 (show subtarget assignments)	1	expressed	lmo0462	16802506	-	hypothetical protein lmo0462 [Listeria m...	161	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05507 (show subtarget assignments)	1	cloned	BA_5374	30259847		putative lipoprotein [Bacillus anthracis...	161	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP91350 (show subtarget assignments)	8	soluble	VV1_3114	27366381		V10 pilin [Vibrio vulnificus CMCP6]	161	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02834 (show subtarget assignments)	1	expressed	GBAA4975	47530273	moaC	molybdenum cofactor biosynthesis protein...	161	Conserved; Drug target functions	Phase 3: June 2008	2EEY	69.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP04299 (show subtarget assignments)	1	purified	VCA0840	15601595		deoxycytidylate deaminase, putative [Vib...	161	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W4L	32.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP00661 (show subtarget assignments)	1	soluble	SACOL0827	57284289		acetyltransferase, putative	161	Drug Target Function	Phase 2: March 2008	1OCX	30.4%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP91779 (show subtarget assignments)	8	crystallized	AAA26652	153043		lincosamide resistance protein [Staphylo...	161	drug resistance / Resistance to lincosamides	Community Requests			Staphylococcus haemolyticus

IDP02229 (show subtarget assignments)	1	cloned	YPO1302	16121584	psaF	hypothetical protein YPO1302 [Yersinia p...	162	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP02262 (show subtarget assignments)	1	soluble	FTT1532	56708566		hypothetical protein FTT1532 [Francisell...	162	Drug Target	Phase 3: June 2008	3NWZ	16%	Francisella tularensis	Unknown function	General

IDP02723 (show subtarget assignments)	1	cloned	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP90978 (show subtarget assignments)	8	selected	y0549	22124463		hypothetical protein y0549 [Yersinia pes...	162	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests			Yersinia pestis

IDP91766 (show subtarget assignments)	8	expressed	b3441	16131313	yhhY	predicted acetyltransferase [Escherichia...	162	drug resistance; innate immunity / E.coli YhhY (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...	Community Requests	2VI7	39.5%	Escherichia coli

IDP00520 (show subtarget assignments)	1	in_pdb 3F6M 3FPI	YPO3360	16123510	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	162	Conserved Gene / Pathway	Phase 2: March 2008	3F6M	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02324 (show subtarget assignments)	1	purified	FTT0581	56707709	coaD	phosphopantetheine adenylyltransferase [...	162	Conserved; Drug target functions	Phase 3: June 2008	1VLH	50.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02058 (show subtarget assignments)	1	purified	YPO0075	16120426	cpxP	periplasmic stress adaptor protein CpxP ...	162	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3ITF	41.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP90836 (show subtarget assignments)	8	purified	Cj0647	15792007		phosphatase, YrbI family [Campylobacter ...	162	Predicted Essential	Community Requests	2R8E	38.3%	Campylobacter jejuni

IDP00898 (show subtarget assignments)	1	soluble	STM2114	16765444	wcaB	putative colanic acid biosynthesis acety...	162	Drug Target Function	Phase 2: March 2008	3GVD	33.3%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP90404 (show subtarget assignments)	8	cloned	CT_654	3329104		hypothetical protein [Chlamydia trachoma...	162	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02343 (show subtarget assignments)	1	expressed	STM0345	16763725		putative inner membrane protein [Salmone...	162	Essential; Drug target functions	Phase 3: June 2008			Salmonella enterica	Hypothetical proteins	Conserved

IDP01378 (show subtarget assignments)	1	cloned	VC0410	15640437		MSHA pilin protein MshC	162	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP02549 (show subtarget assignments)	1	soluble	GBAA0547	47525820		RNA methyltransferase [Bacillus anthraci...	162	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L8U	51.2%	Bacillus anthracis	Protein synthesis	tRNA and rRNA base modification

IDP90718 (show subtarget assignments)	8	in_pdb 3N4J 3N4K	YPO0071	16120422		putative methyltransferase [Yersinia pes...	162	Predicted Essential	Community Requests	3N4J	100%	Yersinia pestis

IDP92061 (show subtarget assignments)	8	selected	TGME49_063490	237832303		ubiquitin-conjugating enzyme E2, putativ...	163	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP02595 (show subtarget assignments)	1	purified	FTT1384c	56708433		acetyltransferase [Francisella tularensi...	163	Drug Target	Phase 3: June 2008			Francisella tularensis	Central intermediary metabolismUnknown function	OtherEnzymes of unknown specificity

IDP90321 (show subtarget assignments)	8	purified	CT_795	3329261		hypothetical protein [Chlamydia trachoma...	163	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP04317 (show subtarget assignments)	1	cloned	YPO0512	218927711		putative lipoprotein [Yersinia pestis CO...	163	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Other

IDP91323 (show subtarget assignments)	8	cloned	VV2_0301	27366745		hypothetical protein VV2_0301 [Vibrio vu...	163	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP90288 (show subtarget assignments)	0	work_stopped	TGME49_093690	211967835		profilin family protein [Toxoplasma gond...	163	Parasite profilin is indispensable for gliding motility, host cell invasion, act...	Community Requests	3NEC	100%	Toxoplasma gondii

IDP01225 (show subtarget assignments)	1	purified	BA_4139	61211625		Phosphopantetheine adenylyltransferase (...	163	Drug Target Function	Phase 2: March 2008	1O6B	71.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP05291 (show subtarget assignments)	1	purified	CD1211	126698807		putative acetyltransferase [Clostridium ...	163	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	1YX0	23.9%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP04072 (show subtarget assignments)	1	in_pdb 3OOW 3OPQ	FTT0896	56707997	purE	phosphoribosylaminoimidazole carboxylase...	163	conserved gene; putative drug target function;	Phase 4: April 2009	3OOW	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90554 (show subtarget assignments)	8	selected	NMPDR 243277.1.peg.3911				163	Predicted Essential	Community Requests	1DD8	81%	Vibrio cholerae

IDP01429 (show subtarget assignments)	1	purified	VC1849	15641851		peptidyl-prolyl cis-trans isomerase B	164	Conserved Gene / Pathway	Phase 2: March 2008	1LOP	64%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP00125 (show subtarget assignments)	0	work_stopped	NT01ST1183	16764320	lrp	leucine-responsive transcriptional regul...	164		Phase 1: October 2007	2GQQ	98.8%	Salmonella enterica	Central intermediary metabolism	Other

IDP02754 (show subtarget assignments)	1	expressed	Cj0527c	15791888	flgC	flagellar basal body rod protein FlgC [C...	164	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP05205 (show subtarget assignments)	1	cloned	CD1770	126699379	ogt2	methylated-DNA--protein-cysteine methylt...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2G7H	32.3%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP90677 (show subtarget assignments)	8	crystallized	Cj0702	15792051	purE	phosphoribosylaminoimidazole carboxylase...	164	Predicted Essential	Community Requests	3TRH	53.7%	Campylobacter jejuni

IDP91274 (show subtarget assignments)	8	selected	NT05BA4272	49181014		acetyl-CoA carboxylase, biotin carboxyl ...	164	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1A6X	23.2%	Bacillus anthracis	Fatty acid and phospholipid metabolism: Biosynthesis

IDP91382 (show subtarget assignments)	8	soluble	VV1_1470	27364854		histone acetyltransferase HPA2 [Vibrio v...	164	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YX0	18.9%	Vibrio vulnificus

IDP01345 (show subtarget assignments)	1	soluble	VC0824	15640841	tpx	tagD protein	164	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP05102 (show subtarget assignments)	1	cloned	CD1130	126698724		putative transglycosylase [Clostridium d...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1QSA	28.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00094 (show subtarget assignments)	0	work_stopped	NT01SF0993	30040622	lrp	regulator for leucine (or lrp) regulon a...	164		Phase 1: October 2007	2GQQ	99.4%	Shigella flexneri	Central intermediary metabolism	Other

IDP91018 (show subtarget assignments)	8	cloned	y2737	22126615		hypothetical protein y2737 [Yersinia pes...	164	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests			Yersinia pestis

IDP05670 (show subtarget assignments)	1	cloned	lmo0617	16802659	-	hypothetical protein lmo0617 [Listeria m...	164	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05689 (show subtarget assignments)	1	cloned	lmo1654	16803694	-	putative cellsurface protein [Listeria m...	164	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP04318 (show subtarget assignments)	1	soluble	YPO0540	115346348	ilvH	acetolactate synthase isozyme III small ...	164	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2F1F	87.2%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP02625 (show subtarget assignments)	1	cloned	GBAA4457	47529752	aroK	shikimate kinase [Bacillus anthracis str...	165	Conserved; Drug target functions	Phase 3: June 2008	1ZUH	35.2%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02243 (show subtarget assignments)	1	cloned	YPO0834	16121142	manX	putative PTS transport protein [Yersinia...	165	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3EYE	41.8%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05257 (show subtarget assignments)	1	crystallized	CD2748	126700363		putative transferase [Clostridium diffic...	165	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2EG0	48.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP91410 (show subtarget assignments)	8	expressed	VV1_0721	27364175		hypothetical protein VV1_0721 [Vibrio vu...	165	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP04019 (show subtarget assignments)	1	cloned	CPF_2080	110799586	spoIIIAH	stage III sporulation protein AH [Clostr...	165	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02358 (show subtarget assignments)	1	purified	YPO1667	16121931	cheW	purine-binding chemotaxis protein [Yersi...	165	Conserved; Drug target functions	Phase 3: June 2008	2HO9	83%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP01237 (show subtarget assignments)	1	soluble	BA_5563	46396830		Glucose-specific phosphotransferase enzy...	165	Drug Target Function	Phase 2: March 2008	1GGR	46.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05390 (show subtarget assignments)	1	soluble	BA_2766	30257370		putative lipoprotein [Bacillus anthracis...	165	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP02012 (show subtarget assignments)	1	soluble	STM4233	16767483	ubiC	chorismate pyruvate lyase [Salmonella ty...	165	Conserved; Drug target functions	Phase 3: June 2008	1G1B	86.1%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP04150 (show subtarget assignments)	1	purified	YPO3707	115349324		conserved hypothetical protein [Yersinia...	165	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP90885 (show subtarget assignments)	8	purified	VC0440	15640467		dihydrofolate reductase [Vibrio cholerae...	165	Predicted Essential	Community Requests	3IA4	52.7%	Vibrio cholerae

IDP00276 (show subtarget assignments)	1	soluble	AAA99437_115-280	323469	N/A	Premembrane/Membrane protein (prM)	166	Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds	Phase 3: June 2008	3C5X	56%	Dengue virus		N/A

IDP00271 (show subtarget assignments)	1	expressed	AF180817_115-280	7329982	N/A	Premembrane/Membrane protein (prM)	166	Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds	Phase 3: June 2008	3C5X	59.6%	Dengue virus		N/A

IDP00266 (show subtarget assignments)	1	cloned	AAX48017_114-279	61652905	N/A	Premembrane/Membrane protein (prM)	166	Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds	Phase 3: June 2008	3C5X	57.2%	Dengue virus		N/A

IDP04282 (show subtarget assignments)	1	selected	YPO1465	115347219		conserved hypothetical protein [Yersinia...	166	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04064 (show subtarget assignments)	1	expressed	BAS0127	49183161		30S ribosomal protein S5 [Bacillus anthr...	166	Proposed to be essential proteins	Phase 4: April 2009	1PKP	75.3%	Bacillus anthracis

IDP05730 (show subtarget assignments)	1	soluble	CD0675	126698254		putative acetyltransferase [Clostridium ...	166	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2GE3	31.3%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP90128 (show subtarget assignments)	8	purified	MPXV_ZAI1979_005_060	68449134		myristylprotein [Monkeypox virus]	166	has N-myristyltransferase target MGxxxS/T/A, similar to VACV-COP-E7R, MPXV-ZAI96...	Community Requests			Monkeypox virus

IDP00803 (show subtarget assignments)	1	purified	SACOL1759	57286194		universal stress protein family	166	Conserved Gene / Pathway	Phase 2: March 2008	1TQ8	30.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00719 (show subtarget assignments)	1	purified	SACOL1457	57284566		PTS system, IIA component	166	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	41%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04276 (show subtarget assignments)	1	soluble	FTT0312c	56707465	folA	dihydrofolate reductase type I [Francise...	166	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JW3	41.6%	Francisella tularensis

IDP00611 (show subtarget assignments)	1	crystallized	SACOL1952	57286299		ferritins family protein	166	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	39.2%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP00230 (show subtarget assignments)	1	purified	YPO3444	16123592	-	putative acetyltransferase	167	Virulence	Phase 1: October 2007	2GE3	18%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00977 (show subtarget assignments)	1	expressed	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00100 (show subtarget assignments)	0	work_stopped	NT01SF2345	30041591	cheW	positive regulator of CheA protein activ...	167		Phase 1: October 2007	2HO9	100%	Shigella flexneri	Cellular processes	Chemotaxis and motility

IDP01030 (show subtarget assignments)	1	cloned	STM2107	16765437	wcaH	GDP-mannose mannosyl hydrolase	167	Conserved Gene / Pathway	Phase 2: March 2008	2I8T	65.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01460 (show subtarget assignments)	1	cloned	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP02240 (show subtarget assignments)	1	cloned	FTT1572c	56708598	ompH	outer membrane protein OmpH [Francisella...	167	Drug Target	Phase 3: June 2008	1SG2	23.4%	Francisella tularensis	Cell envelopeMobile and extrachromosomal element functions	OtherProphage functions

IDP04716 (show subtarget assignments)	1	cloned	YPO0817	218927996		general secretion pathway protein C [Yer...	167	putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04090 (show subtarget assignments)	1	purified	CPF_0694	110800453	aroK	shikimate kinase [Clostridium perfringen...	167	conserved gene; putative drug target function;	Phase 4: April 2009	2PT5	34.1%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP05267 (show subtarget assignments)	1	soluble	lmo0255	16802301	-	hypothetical protein lmo0255 [Listeria m...	167	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Viral functions: General

IDP02689 (show subtarget assignments)	1	cloned	FTT0903	56708004		hypothetical protein FTT0903 [Francisell...	167	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP91271 (show subtarget assignments)	8	selected	NT05BA3690	49180451		prophage LambdaBa01, positive control fa...	167	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP90996 (show subtarget assignments)	8	soluble	y1677	22125572	dps	DNA starvation/stationary phase protecti...	167	other biological interest / global stress response protein	Community Requests	3AK8	82.6%	Yersinia pestis

IDP04052 (show subtarget assignments)	1	cloned	CPF_0049	110799596		putative lipoprotein [Clostridium perfri...	167	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP05386 (show subtarget assignments)	1	soluble	BA_2029	30256682		hypothetical protein BA_2029 [Bacillus a...	168	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP91579 (show subtarget assignments)	8	cloned	BAB37987	13364039	ECs4564	hypothetical protein [Escherichia coli O...	168	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP90549
(show subtarget assignments)

8

in_pdb
3L92
3L93

YPO0053

16120406

coaD

phosphopantetheine adenylyltransferase [...

159

Predicted Essential

Community Requests

3L92

100%

Yersinia pestis

IDP00331
(show subtarget assignments)

1

in_pdb
3RE3

FTT1128

56708205

ispF

2C-methyl-D-erythritol 2,4-cyclodiphosph...

159

Drug Target Function

Phase 2: March 2008

3RE3

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP91549
(show subtarget assignments)

8

cloned

CPF_1846

110800166

hypothetical protein CPF_1846 [Clostridi...

159

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Clostridium perfringens

IDP00308
(show subtarget assignments)

1

soluble

CBU_0288

29653640

coaD

phosphopantetheine adenylyltransferase

159

Drug Target Function

Phase 2: March 2008

3IKZ

47.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02341
(show subtarget assignments)

1

cloned

FTT1313c

56708370

greA

transcriptional elongation factor [Franc...

160

Conserved; Drug target functions

Phase 3: June 2008

1GRJ

63.1%

Francisella tularensis

Regulatory functions

Other

IDP01668
(show subtarget assignments)

1

soluble

GBAA0060

47525314

hypothetical protein GBAA0060 [Bacillus ...

160

Essential;

Phase 3: June 2008

2K4K

29.4%

Bacillus anthracis

Unknown function

General

IDP91581
(show subtarget assignments)

8

cloned

CBU_0080

29540703

hypothetical protein

160

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP00667
(show subtarget assignments)

1

soluble

SACOL1134

57285920

kdtB

lipopolysaccharide core biosynthesis pro...

160

Conserved Gene / Pathway

Phase 2: March 2008

3F3M

100%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90364
(show subtarget assignments)

8

expressed

CT_083

3328478

hypothetical protein [Chlamydia trachoma...

160

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90544
(show subtarget assignments)

8

in_pdb
3Q1H

YPO0486

16120816

folA

dihydrofolate reductase [Yersinia pestis...

160

Predicted Essential

Community Requests

3Q1H

100%

Yersinia pestis

IDP05592
(show subtarget assignments)

1

cloned

BA_3194

30257761

putative lipoprotein [Bacillus anthracis...

160

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP01034
(show subtarget assignments)

0

work_stopped

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90527
(show subtarget assignments)

8

cloned

YPO3179

16123341

pgpA

phosphatidylglycerophosphatase A [Yersin...

161

Predicted Essential

Community Requests

Yersinia pestis

IDP04141
(show subtarget assignments)

1

in_pdb
3V4H

YPO2937

115348601

conserved hypothetical protein [Yersinia...

161

virulence factor; conserved gene;

Phase 4: April 2009

3V4H

100%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01684
(show subtarget assignments)

1

soluble

YPO3559

16123703

hypothetical protein YPO3559 [Yersinia p...

161

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP02165
(show subtarget assignments)

1

soluble

CBU_1993

29542548

folA

dihydrofolate reductase [Coxiella burnet...

161

Conserved; Drug target functions

Phase 3: June 2008

3TQ8

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP91319
(show subtarget assignments)

8

soluble

VV2_0325

27366768

transcriptional regulator [Vibrio vulnif...

161

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2FBK

28.9%

Vibrio vulnificus

IDP05667
(show subtarget assignments)

1

expressed

lmo0462

16802506

-

hypothetical protein lmo0462 [Listeria m...

161

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05507
(show subtarget assignments)

1

cloned

BA_5374

30259847

putative lipoprotein [Bacillus anthracis...

161

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP91350
(show subtarget assignments)

8

soluble

VV1_3114

27366381

V10 pilin [Vibrio vulnificus CMCP6]

161

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP02834
(show subtarget assignments)

1

expressed

GBAA4975

47530273

moaC

molybdenum cofactor biosynthesis protein...

161

Conserved; Drug target functions

Phase 3: June 2008

2EEY

69.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP04299
(show subtarget assignments)

1

purified

VCA0840

15601595

deoxycytidylate deaminase, putative [Vib...

161

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W4L

32.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP00661
(show subtarget assignments)

1

soluble

SACOL0827

57284289

acetyltransferase, putative

161

Drug Target Function

Phase 2: March 2008

1OCX

30.4%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP91779
(show subtarget assignments)

8

crystallized

AAA26652

153043

lincosamide resistance protein [Staphylo...

161

drug resistance / Resistance to lincosamides

Community Requests

Staphylococcus haemolyticus

IDP02229
(show subtarget assignments)

1

cloned

YPO1302

16121584

psaF

hypothetical protein YPO1302 [Yersinia p...

162

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP02262
(show subtarget assignments)

1

soluble

FTT1532

56708566

hypothetical protein FTT1532 [Francisell...

162

Drug Target

Phase 3: June 2008

3NWZ

16%

Francisella tularensis

Unknown function

General

IDP02723
(show subtarget assignments)

1

cloned

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP90978
(show subtarget assignments)

8

selected

y0549

22124463

hypothetical protein y0549 [Yersinia pes...

162

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

Yersinia pestis

IDP91766
(show subtarget assignments)

8

expressed

b3441

16131313

yhhY

predicted acetyltransferase [Escherichia...

162

drug resistance; innate immunity / E.coli YhhY (MccE-ctd homolog) - YhhY, SpeG, YcaA, YcfD show distant homology to...

Community Requests

2VI7

39.5%

Escherichia coli

IDP00520
(show subtarget assignments)

1

in_pdb
3F6M
3FPI

YPO3360

16123510

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

162

Conserved Gene / Pathway

Phase 2: March 2008

3F6M

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02324
(show subtarget assignments)

1

purified

FTT0581

56707709

coaD

phosphopantetheine adenylyltransferase [...

162

Conserved; Drug target functions

Phase 3: June 2008

1VLH

50.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02058
(show subtarget assignments)

1

purified

YPO0075

16120426

cpxP

periplasmic stress adaptor protein CpxP ...

162

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3ITF

41.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP90836
(show subtarget assignments)

8

purified

Cj0647

15792007

phosphatase, YrbI family [Campylobacter ...

162

Predicted Essential

Community Requests

2R8E

38.3%

Campylobacter jejuni

IDP00898
(show subtarget assignments)

1

soluble

STM2114

16765444

wcaB

putative colanic acid biosynthesis acety...

162

Drug Target Function

Phase 2: March 2008

3GVD

33.3%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP90404
(show subtarget assignments)

8

cloned

CT_654

3329104

hypothetical protein [Chlamydia trachoma...

162

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02343
(show subtarget assignments)

1

expressed

STM0345

16763725

putative inner membrane protein [Salmone...

162

Essential; Drug target functions

Phase 3: June 2008

Salmonella enterica

Hypothetical proteins

Conserved

IDP01378
(show subtarget assignments)

1

cloned

VC0410

15640437

MSHA pilin protein MshC

162

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02549
(show subtarget assignments)

1

soluble

GBAA0547

47525820

RNA methyltransferase [Bacillus anthraci...

162

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L8U

51.2%

Bacillus anthracis

Protein synthesis

tRNA and rRNA base modification

IDP90718
(show subtarget assignments)

8

in_pdb
3N4J
3N4K

YPO0071

16120422

putative methyltransferase [Yersinia pes...

162

Predicted Essential

Community Requests

3N4J

100%

Yersinia pestis

IDP92061
(show subtarget assignments)

8

selected

TGME49_063490

237832303

ubiquitin-conjugating enzyme E2, putativ...

163

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP02595
(show subtarget assignments)

1

purified

FTT1384c

56708433

acetyltransferase [Francisella tularensi...

163

Drug Target

Phase 3: June 2008

Francisella tularensis

Central intermediary metabolismUnknown function

OtherEnzymes of unknown specificity

IDP90321
(show subtarget assignments)

8

purified

CT_795

3329261

hypothetical protein [Chlamydia trachoma...

163

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP04317
(show subtarget assignments)

1

cloned

YPO0512

218927711

putative lipoprotein [Yersinia pestis CO...

163

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Other

IDP91323
(show subtarget assignments)

8

cloned

VV2_0301

27366745

hypothetical protein VV2_0301 [Vibrio vu...

163

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP90288
(show subtarget assignments)

0

work_stopped

TGME49_093690

211967835

profilin family protein [Toxoplasma gond...

163

Parasite profilin is indispensable for gliding motility, host cell invasion, act...

Community Requests

3NEC

100%

Toxoplasma gondii

IDP01225
(show subtarget assignments)

1

purified

BA_4139

61211625

Phosphopantetheine adenylyltransferase (...

163

Drug Target Function

Phase 2: March 2008

1O6B

71.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP05291
(show subtarget assignments)

1

purified

CD1211

126698807

putative acetyltransferase [Clostridium ...

163

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

1YX0

23.9%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP04072
(show subtarget assignments)

1

in_pdb
3OOW
3OPQ

FTT0896

56707997

purE

phosphoribosylaminoimidazole carboxylase...

163

conserved gene; putative drug target function;

Phase 4: April 2009

3OOW

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90554
(show subtarget assignments)

8

selected

NMPDR 243277.1.peg.3911

163

Predicted Essential

Community Requests

1DD8

81%

Vibrio cholerae

IDP01429
(show subtarget assignments)

1

purified

VC1849

15641851

peptidyl-prolyl cis-trans isomerase B

164

Conserved Gene / Pathway

Phase 2: March 2008

1LOP

64%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP00125
(show subtarget assignments)

0

work_stopped

NT01ST1183

16764320

lrp

leucine-responsive transcriptional regul...

164

Phase 1: October 2007

2GQQ

98.8%

Salmonella enterica

Central intermediary metabolism

Other

IDP02754
(show subtarget assignments)

1

expressed

Cj0527c

15791888

flgC

flagellar basal body rod protein FlgC [C...

164

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP05205
(show subtarget assignments)

1

cloned

CD1770

126699379

ogt2

methylated-DNA--protein-cysteine methylt...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2G7H

32.3%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP90677
(show subtarget assignments)

8

crystallized

Cj0702

15792051

purE

phosphoribosylaminoimidazole carboxylase...

164

Predicted Essential

Community Requests

3TRH

53.7%

Campylobacter jejuni

IDP91274
(show subtarget assignments)

8

selected

NT05BA4272

49181014

acetyl-CoA carboxylase, biotin carboxyl ...

164

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1A6X

23.2%

Bacillus anthracis

Fatty acid and phospholipid metabolism: Biosynthesis

IDP91382
(show subtarget assignments)

8

soluble

VV1_1470

27364854

histone acetyltransferase HPA2 [Vibrio v...

164

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YX0

18.9%

Vibrio vulnificus

IDP01345
(show subtarget assignments)

1

soluble

VC0824

15640841

tpx

tagD protein

164

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05102
(show subtarget assignments)

1

cloned

CD1130

126698724

putative transglycosylase [Clostridium d...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1QSA

28.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00094
(show subtarget assignments)

0

work_stopped

NT01SF0993

30040622

lrp

regulator for leucine (or lrp) regulon a...

164

Phase 1: October 2007

2GQQ

99.4%

Shigella flexneri

Central intermediary metabolism

Other

IDP91018
(show subtarget assignments)

8

cloned

y2737

22126615

hypothetical protein y2737 [Yersinia pes...

164

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

Yersinia pestis

IDP05670
(show subtarget assignments)

1

cloned

lmo0617

16802659

-

hypothetical protein lmo0617 [Listeria m...

164

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05689
(show subtarget assignments)

1

cloned

lmo1654

16803694

-

putative cellsurface protein [Listeria m...

164

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP04318
(show subtarget assignments)

1

soluble

YPO0540

115346348

ilvH

acetolactate synthase isozyme III small ...

164

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2F1F

87.2%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP02625
(show subtarget assignments)

1

cloned

GBAA4457

47529752

aroK

shikimate kinase [Bacillus anthracis str...

165

Conserved; Drug target functions

Phase 3: June 2008

1ZUH

35.2%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02243
(show subtarget assignments)

1

cloned

YPO0834

16121142

manX

putative PTS transport protein [Yersinia...

165

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3EYE

41.8%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05257
(show subtarget assignments)

1

crystallized

CD2748

126700363

putative transferase [Clostridium diffic...

165

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2EG0

48.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP91410
(show subtarget assignments)

8

expressed

VV1_0721

27364175

hypothetical protein VV1_0721 [Vibrio vu...

165

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP04019
(show subtarget assignments)

1

cloned

CPF_2080

110799586

spoIIIAH

stage III sporulation protein AH [Clostr...

165

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02358
(show subtarget assignments)

1

purified

YPO1667

16121931

cheW

purine-binding chemotaxis protein [Yersi...

165

Conserved; Drug target functions

Phase 3: June 2008

2HO9

83%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP01237
(show subtarget assignments)

1

soluble

BA_5563

46396830

Glucose-specific phosphotransferase enzy...

165

Drug Target Function

Phase 2: March 2008

1GGR

46.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05390
(show subtarget assignments)

1

soluble

BA_2766

30257370

putative lipoprotein [Bacillus anthracis...

165

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP02012
(show subtarget assignments)

1

soluble

STM4233

16767483

ubiC

chorismate pyruvate lyase [Salmonella ty...

165

Conserved; Drug target functions

Phase 3: June 2008

1G1B

86.1%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP04150
(show subtarget assignments)

1

purified

YPO3707

115349324

conserved hypothetical protein [Yersinia...

165

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP90885
(show subtarget assignments)

8

purified

VC0440

15640467

dihydrofolate reductase [Vibrio cholerae...

165

Predicted Essential

Community Requests

3IA4

52.7%

Vibrio cholerae

IDP00276
(show subtarget assignments)

1

soluble

AAA99437_115-280

323469

N/A

Premembrane/Membrane protein (prM)

166

Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds

Phase 3: June 2008

3C5X

56%

Dengue virus

N/A

IDP00271
(show subtarget assignments)

1

expressed

AF180817_115-280

7329982

N/A

Premembrane/Membrane protein (prM)

166

Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds

Phase 3: June 2008

3C5X

59.6%

Dengue virus

N/A

IDP00266
(show subtarget assignments)

1

cloned

AAX48017_114-279

61652905

N/A

Premembrane/Membrane protein (prM)

166

Very hydrophilic; 6 Cys residues form intramolecular disulfide bonds

Phase 3: June 2008

3C5X

57.2%

Dengue virus

N/A

IDP04282
(show subtarget assignments)

1

selected

YPO1465

115347219

conserved hypothetical protein [Yersinia...

166

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04064
(show subtarget assignments)

1

expressed

BAS0127

49183161

30S ribosomal protein S5 [Bacillus anthr...

166

Proposed to be essential proteins

Phase 4: April 2009

1PKP

75.3%

Bacillus anthracis

IDP05730
(show subtarget assignments)

1

soluble

CD0675

126698254

putative acetyltransferase [Clostridium ...

166

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2GE3

31.3%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP90128
(show subtarget assignments)

8

purified

MPXV_ZAI1979_005_060

68449134

myristylprotein [Monkeypox virus]

166

has N-myristyltransferase target MGxxxS/T/A, similar to VACV-COP-E7R, MPXV-ZAI96...

Community Requests

Monkeypox virus

IDP00803
(show subtarget assignments)

1

purified

SACOL1759

57286194

universal stress protein family

166

Conserved Gene / Pathway

Phase 2: March 2008

1TQ8

30.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00719
(show subtarget assignments)

1

purified

SACOL1457

57284566

PTS system, IIA component

166

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

41%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04276
(show subtarget assignments)

1

soluble

FTT0312c

56707465

folA

dihydrofolate reductase type I [Francise...

166

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JW3

41.6%

Francisella tularensis

IDP00611
(show subtarget assignments)

1

crystallized

SACOL1952

57286299

ferritins family protein

166

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

39.2%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP00230
(show subtarget assignments)

1

purified

YPO3444

16123592

-

putative acetyltransferase

167

Virulence

Phase 1: October 2007

2GE3

18%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00977
(show subtarget assignments)

1

expressed

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00100
(show subtarget assignments)

0

work_stopped

NT01SF2345

30041591

cheW

positive regulator of CheA protein activ...

167

Phase 1: October 2007

2HO9

100%

Shigella flexneri

Cellular processes

Chemotaxis and motility

IDP01030
(show subtarget assignments)

1

cloned

STM2107

16765437

wcaH

GDP-mannose mannosyl hydrolase

167

Conserved Gene / Pathway

Phase 2: March 2008

2I8T

65.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01460
(show subtarget assignments)

1

cloned

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP02240
(show subtarget assignments)

1

cloned

FTT1572c

56708598

ompH

outer membrane protein OmpH [Francisella...

167

Drug Target

Phase 3: June 2008

1SG2

23.4%

Francisella tularensis

Cell envelopeMobile and extrachromosomal element functions

OtherProphage functions

IDP04716
(show subtarget assignments)

1

cloned

YPO0817

218927996

general secretion pathway protein C [Yer...

167

putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04090
(show subtarget assignments)

1

purified

CPF_0694

110800453

aroK

shikimate kinase [Clostridium perfringen...

167

conserved gene; putative drug target function;

Phase 4: April 2009

2PT5

34.1%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP05267
(show subtarget assignments)

1

soluble

lmo0255

16802301

-

hypothetical protein lmo0255 [Listeria m...

167

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Viral functions: General

IDP02689
(show subtarget assignments)

1

cloned

FTT0903

56708004

hypothetical protein FTT0903 [Francisell...

167

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP91271
(show subtarget assignments)

8

selected

NT05BA3690

49180451

prophage LambdaBa01, positive control fa...

167

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP90996
(show subtarget assignments)

8

soluble

y1677

22125572

dps

DNA starvation/stationary phase protecti...

167

other biological interest / global stress response protein

Community Requests

3AK8

82.6%

Yersinia pestis

IDP04052
(show subtarget assignments)

1

cloned

CPF_0049

110799596

putative lipoprotein [Clostridium perfri...

167

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP05386
(show subtarget assignments)

1

soluble

BA_2029

30256682

hypothetical protein BA_2029 [Bacillus a...

168

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP91579
(show subtarget assignments)

8

cloned

BAB37987

13364039

ECs4564

hypothetical protein [Escherichia coli O...

168

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli