Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02605 (show subtarget assignments)	1	cloned	YPO3502	16123648	hflB	ATP-dependent metalloprotease [Yersinia ...	644	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	2DHR	40.7%	Yersinia pestis	Cellular processes	Cell division

IDP00680 (show subtarget assignments)	1	soluble	SACOL1721	57284732	clpX	ATP-dependent protease ATP-binding subun...	420	Drug Target Function	Phase 2: March 2008	3HWS	52.4%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00672 (show subtarget assignments)	1	purified	SACOL1271	57286009	hslU	ATP-dependent protease ATP-binding subun...	467	Drug Target Function	Phase 2: March 2008	1G3I	47.1%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP02473 (show subtarget assignments)	1	purified	GBAA3967	47529257	hslU	ATP-dependent protease ATP-binding subun...	463	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1E94	50.8%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01666 (show subtarget assignments)	1	soluble	GBAA4704	47530003	clpX	ATP-dependent protease ATP-binding subun...	419	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HTE	52.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02333 (show subtarget assignments)	1	soluble	FTT0625	56707750	clpX	ATP-dependent protease ATP-binding subun...	417	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3HWS	54.7%	Francisella tularensis	Protein fate	Protein folding and stabilizationDegradation of proteins, peptides, and glycopeptides

IDP01620 (show subtarget assignments)	1	cloned	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01137 (show subtarget assignments)	1	in_pdb 3TY6	BA_3968	47605672		ATP-dependent protease hslV	180	Drug Target Function	Phase 2: March 2008	3TY6	100%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01132 (show subtarget assignments)	1	soluble	BA_4703	30259197	loN2	ATP-dependent protease LA	557	Drug Target Function	Phase 2: March 2008	3K1J	26.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02793 (show subtarget assignments)	1	cloned	GBAA4702	47530001	loN	ATP-dependent protease La 1 [Bacillus an...	773	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3M6A	53.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90346 (show subtarget assignments)	8	cloned	CT344	15605067	lon	ATP-dependent protease La [Chlamydia tra...	819	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3M6A	30.8%	Chlamydia trachomatis

IDP02671 (show subtarget assignments)	1	selected	lmo0997	16803037	clpE	ATP-dependent protease [Listeria monocyt...	724	Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs	Phase 3: June 2008	1QVR	46.3%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP04393 (show subtarget assignments)	1	cloned	CPF_1645	110798596	lonB	ATP-dependent protease LonB [Clostridium...	570	conserved gene; putative drug target function;	Phase 4: April 2009	3K1J	29.4%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00568 (show subtarget assignments)	0	work_stopped	YPO0106	16120453	hslV	ATP-dependent protease peptidase subunit...	174	Conserved Gene / Pathway	Phase 2: March 2008	1E94	90.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01475 (show subtarget assignments)	1	purified	VC2675	15642670		ATP-dependent protease peptidase subunit...	185	Conserved Gene / Pathway	Phase 2: March 2008	1E94	78.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02114 (show subtarget assignments)	1	purified	FTT0688c	56707808	hslV	ATP-dependent protease peptidase subunit...	183	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1G3I	59.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02476 (show subtarget assignments)	1	cloned	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP00550 (show subtarget assignments)	1	soluble	YPO3488	16123634	deaD	ATP-dependent RNA helicase DeaD	664	Virulence Associated Factor	Phase 2: March 2008	1HV8	23.3%	Yersinia pestis	Transcription	Other

IDP91430 (show subtarget assignments)	8	cloned	VV1_0534	27363997		ATP-dependent RNA helicase SrmB [Vibrio ...	408	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2I4I	32.8%	Vibrio vulnificus

IDP00773 (show subtarget assignments)	1	purified	SACOL0569	57285587		ATP:guanido phosphotransferase	335	Drug Target Function	Phase 2: March 2008	3L2D	22.7%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP90839 (show subtarget assignments)	8	purified	Cj0641	15792001		ATP-NAD kinase, putative [Campylobacter ...	286	Predicted Essential	Community Requests	2AN1	31.9%	Campylobacter jejuni

IDP00554 (show subtarget assignments)	1	purified	YPO1549	16121822	hisG	ATP phosphoribosyltransferase	299	Virulence Associated Factor	Phase 2: March 2008	1H3D	88%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP90801 (show subtarget assignments)	8	soluble	Cj1597	15792902	hisG	ATP phosphoribosyltransferase [Campyloba...	299	Predicted Essential	Community Requests	1H3D	66.2%	Campylobacter jejuni

IDP02488 (show subtarget assignments)	1	purified	GBAA1425	47526697	hisG	ATP phosphoribosyltransferase catalytic ...	211	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1Z7M	49.8%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP04049 (show subtarget assignments)	1	soluble	VC1132	15641145	hisG	ATP phosphoribosyltransferase [Vibrio ch...	304	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1H3D	65.8%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP92059 (show subtarget assignments)	8	selected	TGME49_061950	237832039		ATP synthase beta chain, putative [Toxop...	560	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests			Toxoplasma gondii

IDP00817 (show subtarget assignments)	1	purified	SACOL2098	57286314	atpH	ATP synthase F1, delta subunit	179	Drug Target Function	Phase 2: March 2008	2WSS	21.2%	Staphylococcus aureus	Energy metabolism	ATP-proton motive force interconversion

IDP01018 (show subtarget assignments)	1	expressed	STM2894	16766200	invC	ATP synthase SpaL	431	Conserved Gene / Pathway	Phase 2: March 2008	2OBL	38.7%	Salmonella enterica	Transport and binding proteins	Other

IDP01859 (show subtarget assignments)	1	cloned	lmo2558	16804596	ami	autolysin, amidase [Listeria monocytogen...	917	Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838	Phase 3: June 2008	1M9S	14.7%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP05248 (show subtarget assignments)	1	cloned	lmo2691	16804728	-	autolysin [Listeria monocytogenes EGD-e]...	590	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	16.1%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01989 (show subtarget assignments)	1	purified	STM2646	16765966	yfiD	autonomous glycyl radical cofactor GrcA ...	127	Conserved; Drug target functions	Phase 3: June 2008	1CM5	38.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP91511 (show subtarget assignments)	8	cloned	VV2_0479	27366913		autotransporter adhesin [Vibrio vulnific...	5206	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3EEB	3.7%	Vibrio vulnificus

IDP04035 (show subtarget assignments)	1	in_pdb 3P0R	BAS5262	49188247		azoreductase [Bacillus anthracis str. St...	208	Proposed to be essential proteins	Phase 4: April 2009	3P0R	100%	Bacillus anthracis

IDP90903 (show subtarget assignments)	8	purified	VC0390	15640417	metH	B12-dependent methionine synthase [Vibri...	1226	Predicted Essential	Community Requests	3BUL	33.8%	Vibrio cholerae

IDP02636 (show subtarget assignments)	1	expressed	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP90123 (show subtarget assignments)	8	purified	MPXV_ZAI1979_005_035	68449109		B15R-like protein [Monkeypox virus]	149	similar to VACV-COP-K7R, MPXV-ZAI96-C6R	Community Requests	2K36	94%	Monkeypox virus

IDP01160 (show subtarget assignments)	1	expressed	BA_4774	30259261		bacitracin ABC transporter, ATP-binding ...	307	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	25.7%	Bacillus anthracis	Transport and binding proteins	Other

IDP04245 (show subtarget assignments)	1	cloned	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP00025 (show subtarget assignments)	1	soluble	BA_0285	30253779		bacitracin ABC transporter, ATP-binding ...	309	Virulence	Phase 1: October 2007	1OXS	30.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP05181 (show subtarget assignments)	1	soluble	BA_4729	30259221		bacterial extracellular solute-binding p...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1UQW	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05364 (show subtarget assignments)	1	soluble	BA_2881	30257478		bacterial extracellular solute-binding p...	578	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3M8U	19.2%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP00058 (show subtarget assignments)	1	soluble	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91998 (show subtarget assignments)	8	selected	SpneCM_010100004262	298254815		bacteriocin, lactococcin 972 family prot...	99	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP00032 (show subtarget assignments)	1	purified	BA_1221	30255171		bacteriocin O-metyltransferase, putative...	281	Virulence	Phase 1: October 2007	2WK1	36.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01964 (show subtarget assignments)	1	in_pdb 3KWO	Cj1534c	15792842		bacterioferritin [Campylobacter jejuni s...	149	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3KWO	100%	Campylobacter jejuni	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP05576 (show subtarget assignments)	1	cloned	BA_0536	30254062	bcP	bacterioferritin comigratory protein [Ba...	151	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRN	41.7%	Bacillus anthracis	Cellular processes: Detoxification

IDP91463 (show subtarget assignments)	8	expressed	VV1_0079	27363564		bacteriophage phi gp55-like protein [Vib...	159	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91726 (show subtarget assignments)	8	selected	NP_116784	14670388	BAD	bcl2 antagonist of cell death [Homo sapi...	168	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2BZW	14.9%	Homo sapiens

IDP91664 (show subtarget assignments)	8	selected	NP_055232	15193488	BBC3	bcl-2-binding component 3 isoform 4 [Hom...	193	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2ROC	12.4%	Homo sapiens

IDP91727 (show subtarget assignments)	8	selected	NP_619527	20336315	BCL2L11	bcl-2-like protein 11 isoform 1 [Homo sa...	198	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2NL9	13.1%	Homo sapiens

IDP91381 (show subtarget assignments)	8	cloned	VV1_1469	27364853		Beta-galactosidase/beta-glucuronidase [V...	258	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91983 (show subtarget assignments)	8	selected	SpneCM_010100000697	298254118		beta-galactosidase [Streptococcus pneumo...	2233	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3GM8	12.4%	Streptococcus pneumoniae

IDP00463 (show subtarget assignments)	1	soluble	YPO1615	16121883		beta-hexosaminidase	343	Drug Target Function	Phase 2: March 2008	2OXN	55.1%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91429 (show subtarget assignments)	8	purified	VV1_0496	27363960		beta-hexosaminidase [Vibrio vulnificus C...	328	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2OXN	73.5%	Vibrio vulnificus

IDP00699 (show subtarget assignments)	1	in_pdb 3ED6 3FG0	SACOL2628	57286533	betB	betaine aldehyde dehydrogenase	496	Conserved Gene / Pathway	Phase 2: March 2008	3ED6	100%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP91247 (show subtarget assignments)	8	selected	HP0558	2313676		beta ketoacyl-acyl carrier protein synth...	412	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1J3N	49.4%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP91246 (show subtarget assignments)	8	selected	HP0202	2313291		beta-ketoacyl-acyl carrier protein synth...	331	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2EBD	43.8%	Helicobacter pylori	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00303 (show subtarget assignments)	1	purified	CBU_0035	29653398		beta-ketoacyl synthase	424	Drug Target Function	Phase 2: March 2008	3E60	36.8%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00048 (show subtarget assignments)	1	cloned	BA_3330	30257875		beta-lactam antibiotic acylase family pr...	796	Virulence	Phase 1: October 2007	1KEH	22.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00042 (show subtarget assignments)	1	soluble	BA_2507	30257134	bla1	beta-lactamase	309	Virulence	Phase 1: October 2007	3QHY	87.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91877 (show subtarget assignments)	8	selected	CAB89086	7649401	fox-4	beta-lactamase class C [Escherichia coli...	382	potential drug target / Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...	Community Requests	1ZKJ	71.7%	Escherichia coli

IDP00523 (show subtarget assignments)	1	in_pdb 3OZH 3RJU	YPO1224	16121513	ampH	beta-lactamase/D-alanine carboxypeptidas...	388	Conserved Gene / Pathway	Phase 2: March 2008	3OZH	89.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02545 (show subtarget assignments)	1	in_pdb 3P09	FTT0611c	56707736		beta-lactamase [Francisella tularensis s...	287	Drug Target	Phase 3: June 2008	3P09	100%	Francisella tularensis	Cellular processes	Toxin production and resistance

IDP00052 (show subtarget assignments)	1	purified	BA_3500	30258038	bla2	beta-lactamase II	256	Virulence	Phase 1: October 2007	1BC2	81.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91950 (show subtarget assignments)	8	selected	SpneCM_010100006639	298255269		beta-N-acetylhexosaminidase [Streptococc...	1312	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3RPM	35.5%	Streptococcus pneumoniae

IDP05298 (show subtarget assignments)	1	purified	CD2189	126699805	pgmB	beta-phosphoglucomutase [Clostridium dif...	226	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3NAS	46.9%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05309 (show subtarget assignments)	1	purified	CD3128	126700746	pgmB	beta-phosphoglucomutase [Clostridium dif...	223	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3NAS	47.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91632 (show subtarget assignments)	8	purified	BAB35248	13361290	ECs1825	bfpT-regulated chaperone-like protein [E...	196	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LW8	39.8%	Escherichia coli

IDP90139 (show subtarget assignments)	8	cloned	MPXV_ZAI1979_005_182	68449253		bifunctional 21kDa precursor protein of ...	182	virulence, ER resident, similar to VACV-COP-B7R, N-terminal signal peptide, bifu...	Community Requests			Monkeypox virus

IDP02613 (show subtarget assignments)	1	expressed	YPO3530	16123676	cpdB	bifunctional 2',3'-cyclic nucleotide 2'-...	656	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3JYF	40.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP00326 (show subtarget assignments)	0	work_stopped	Cj1607	15792912	ispDF	bifunctional 2-C-methyl-D-erythritol 4-p...	371	Drug Target Function	Phase 2: March 2008	1W55	100%	Campylobacter jejuni	Amino acid biosynthesis	Histidine family

IDP90729 (show subtarget assignments)	8	crystallized	Cj0572	15791932	ribA	bifunctional 3,4-dihydroxy-2-butanone 4-...	339	Predicted Essential	Community Requests	3MGZ	29.5%	Campylobacter jejuni

IDP00804 (show subtarget assignments)	1	expressed	SACOL1787	57286221		bifunctional 3-deoxy-7-phosphoheptulonat...	363	Drug Target Function	Phase 2: March 2008	3NVT	66.9%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP00348 (show subtarget assignments)	1	in_pdb 3TFC 3NVT	lmo1600	16803640	aroA	bifunctional 3-deoxy-7-phosphoheptulonat...	361	Drug Target Function	Phase 2: March 2008	3NVT	100%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP02645 (show subtarget assignments)	1	soluble	STM1749	16765093	adhE	bifunctional acetaldehyde-CoA/alcohol de...	892	Conserved; Essential; Drug target functions	Phase 3: June 2008	3MY7	38.7%	Salmonella enterica	Energy metabolism	Fermentation

IDP00585 (show subtarget assignments)	1	expressed	YPO0116	16120461	metL	bifunctional aspartate kinase II/homoser...	811	Virulence Associated Factor	Phase 2: March 2008	1EBF	15.5%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP91292 (show subtarget assignments)	8	selected	SPA2526	56414632	pheA	bifunctional chorismate mutase/prephenat...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	24.9%	Salmonella enterica

IDP00461 (show subtarget assignments)	1	expressed	YPO3285	16123440	tyrA	bifunctional chorismate mutase/prephenat...	373	Conserved Gene / Pathway	Phase 2: March 2008	2PV7	47.2%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP91007 (show subtarget assignments)	8	expressed	y1938	22125830		bifunctional cysteine desulfurase/seleno...	410	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	1I29	69.8%	Yersinia pestis

IDP90898 (show subtarget assignments)	8	soluble	STM0416	16763796	ribD	bifunctional diaminohydroxyphosphoribosy...	367	Predicted Essential	Community Requests	2G6V	89.4%	Salmonella enterica

IDP90906 (show subtarget assignments)	8	purified	YPO3183	16123345	ribD	bifunctional diaminohydroxyphosphoribosy...	369	Predicted Essential	Community Requests	2G6V	71.8%	Yersinia pestis

IDP90567 (show subtarget assignments)	8	in_pdb 3R2E	YPO0648	16120973	folB	bifunctional dihydroneopterin aldolase/d...	119	Predicted Essential	Community Requests	3R2E	100%	Yersinia pestis

IDP05132 (show subtarget assignments)	1	cloned	CD0262	126697834	flhB	bifunctional flagellar biosynthesis prot...	604	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2JLH	7.9%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP90776 (show subtarget assignments)	8	purified	STM2365	16765692	folC	bifunctional folylpolyglutamate synthase...	422	Predicted Essential	Community Requests	1W78	86.7%	Salmonella enterica

IDP90784 (show subtarget assignments)	8	in_pdb 3PYZ 3NRS 3N2A 3QCZ	YPO2769	16122973	folC	bifunctional folylpolyglutamate synthase...	434	Predicted Essential	Community Requests	3N2A	100%	Yersinia pestis

IDP91288 (show subtarget assignments)	8	selected	SPA1153	56413351	trpD	bifunctional glutamine amidotransferase/...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	47.3%	Salmonella enterica

IDP91224 (show subtarget assignments)	8	selected	SF1266	24112662	trpD	bifunctional glutamine amidotransferase/...	531	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1KGZ	46.7%	Shigella flexneri

IDP01050 (show subtarget assignments)	1	cloned	STM3201	16766501	glnE	bifunctional glutamine-synthetase adenyl...	947	Conserved Gene / Pathway	Phase 2: March 2008	3K7D	47.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP02560 (show subtarget assignments)	1	cloned	GBAA0268	47777798	guaA	bifunctional GMP synthase/glutamine amid...	512	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPM	52.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90695 (show subtarget assignments)	8	purified	Cj1248	15792572	guaA	bifunctional GMP synthase/glutamine amid...	511	Predicted Essential	Community Requests	1GPM	51.8%	Campylobacter jejuni

IDP04199 (show subtarget assignments)	1	cloned	CPF_2557	110800712	guaA	bifunctional GMP synthase/glutamine amid...	509	conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	52.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02219 (show subtarget assignments)	1	purified	FTT1019c	56708108	guaA	bifunctional GMP synthase/glutamine amid...	516	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1GPM	61.1%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90256 (show subtarget assignments)	8	purified	SAR0409	49482642	guaA	bifunctional GMP synthase/glutamine amid...	513	(From requestor) Identified potential S. aureus drug target. Would like to devel...	Community Requests	1GPM	51.2%	Staphylococcus aureus

IDP00558 (show subtarget assignments)	1	purified	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90143 (show subtarget assignments)	8	cloned	MPXV_ZAI1979_005_189	68449260		bifunctional IL-1-beta-inhibitor/prevent...	210	contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184	Community Requests	3O4O	29.5%	Monkeypox virus

IDP90144 (show subtarget assignments)	8	soluble	MPXV_ZAI1979_005_189.5	68449261		bifunctional IL-1-beta-inhibitor/prevent...	126	contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184	Community Requests	1G0Y	27.8%	Monkeypox virus

IDP01871 (show subtarget assignments)	1	cloned	FTT1795c	56708783	trpC	bifunctional indole-3-glycerol phosphate...	453	Conserved; Drug target functions	Phase 3: June 2008	1PII	56.1%	Francisella tularensis	Amino acid biosynthesisFatty acid and phospholipid metabolism	Aromatic amino acid familyHistidine family,Biosynthesis

IDP02235 (show subtarget assignments)	1	purified	FTT1105c	56708184	msrA1	bifunctional methionine sulfoxide reduct...	284	Drug Target	Phase 3: June 2008	2GT3	23.2%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP01477 (show subtarget assignments)	1	purified	VC2762	15642755	glmU	bifunctional N-acetylglucosamine-1-phosp...	453	Drug Target Function	Phase 2: March 2008	1HV9	67.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00427 (show subtarget assignments)	1	in_pdb 3FWW	YPO4119	16124227	glmU	bifunctional N-acetylglucosamine-1-phosp...	456	Drug Target Function	Phase 2: March 2008	3FWW	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02605
(show subtarget assignments)

1

cloned

YPO3502

16123648

hflB

ATP-dependent metalloprotease [Yersinia ...

644

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

2DHR

40.7%

Yersinia pestis

Cellular processes

Cell division

IDP00680
(show subtarget assignments)

1

soluble

SACOL1721

57284732

clpX

ATP-dependent protease ATP-binding subun...

420

Drug Target Function

Phase 2: March 2008

3HWS

52.4%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00672
(show subtarget assignments)

1

purified

SACOL1271

57286009

hslU

ATP-dependent protease ATP-binding subun...

467

Drug Target Function

Phase 2: March 2008

1G3I

47.1%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP02473
(show subtarget assignments)

1

purified

GBAA3967

47529257

hslU

ATP-dependent protease ATP-binding subun...

463

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1E94

50.8%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01666
(show subtarget assignments)

1

soluble

GBAA4704

47530003

clpX

ATP-dependent protease ATP-binding subun...

419

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HTE

52.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02333
(show subtarget assignments)

1

soluble

FTT0625

56707750

clpX

ATP-dependent protease ATP-binding subun...

417

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3HWS

54.7%

Francisella tularensis

Protein fate

Protein folding and stabilizationDegradation of proteins, peptides, and glycopeptides

IDP01620
(show subtarget assignments)

1

cloned

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01137
(show subtarget assignments)

1

in_pdb
3TY6

BA_3968

47605672

ATP-dependent protease hslV

180

Drug Target Function

Phase 2: March 2008

3TY6

100%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01132
(show subtarget assignments)

1

soluble

BA_4703

30259197

loN2

ATP-dependent protease LA

557

Drug Target Function

Phase 2: March 2008

3K1J

26.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02793
(show subtarget assignments)

1

cloned

GBAA4702

47530001

loN

ATP-dependent protease La 1 [Bacillus an...

773

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3M6A

53.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90346
(show subtarget assignments)

8

cloned

CT344

15605067

lon

ATP-dependent protease La [Chlamydia tra...

819

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3M6A

30.8%

Chlamydia trachomatis

IDP02671
(show subtarget assignments)

1

selected

lmo0997

16803037

clpE

ATP-dependent protease [Listeria monocyt...

724

Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs

Phase 3: June 2008

1QVR

46.3%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP04393
(show subtarget assignments)

1

cloned

CPF_1645

110798596

lonB

ATP-dependent protease LonB [Clostridium...

570

conserved gene; putative drug target function;

Phase 4: April 2009

3K1J

29.4%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00568
(show subtarget assignments)

0

work_stopped

YPO0106

16120453

hslV

ATP-dependent protease peptidase subunit...

174

Conserved Gene / Pathway

Phase 2: March 2008

1E94

90.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01475
(show subtarget assignments)

1

purified

VC2675

15642670

ATP-dependent protease peptidase subunit...

185

Conserved Gene / Pathway

Phase 2: March 2008

1E94

78.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02114
(show subtarget assignments)

1

purified

FTT0688c

56707808

hslV

ATP-dependent protease peptidase subunit...

183

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1G3I

59.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02476
(show subtarget assignments)

1

cloned

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP00550
(show subtarget assignments)

1

soluble

YPO3488

16123634

deaD

ATP-dependent RNA helicase DeaD

664

Virulence Associated Factor

Phase 2: March 2008

1HV8

23.3%

Yersinia pestis

Transcription

Other

IDP91430
(show subtarget assignments)

8

cloned

VV1_0534

27363997

ATP-dependent RNA helicase SrmB [Vibrio ...

408

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2I4I

32.8%

Vibrio vulnificus

IDP00773
(show subtarget assignments)

1

purified

SACOL0569

57285587

ATP:guanido phosphotransferase

335

Drug Target Function

Phase 2: March 2008

3L2D

22.7%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP90839
(show subtarget assignments)

8

purified

Cj0641

15792001

ATP-NAD kinase, putative [Campylobacter ...

286

Predicted Essential

Community Requests

2AN1

31.9%

Campylobacter jejuni

IDP00554
(show subtarget assignments)

1

purified

YPO1549

16121822

hisG

ATP phosphoribosyltransferase

299

Virulence Associated Factor

Phase 2: March 2008

1H3D

88%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP90801
(show subtarget assignments)

8

soluble

Cj1597

15792902

hisG

ATP phosphoribosyltransferase [Campyloba...

299

Predicted Essential

Community Requests

1H3D

66.2%

Campylobacter jejuni

IDP02488
(show subtarget assignments)

1

purified

GBAA1425

47526697

hisG

ATP phosphoribosyltransferase catalytic ...

211

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1Z7M

49.8%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP04049
(show subtarget assignments)

1

soluble

VC1132

15641145

hisG

ATP phosphoribosyltransferase [Vibrio ch...

304

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1H3D

65.8%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP92059
(show subtarget assignments)

8

selected

TGME49_061950

237832039

ATP synthase beta chain, putative [Toxop...

560

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

Toxoplasma gondii

IDP00817
(show subtarget assignments)

1

purified

SACOL2098

57286314

atpH

ATP synthase F1, delta subunit

179

Drug Target Function

Phase 2: March 2008

2WSS

21.2%

Staphylococcus aureus

Energy metabolism

ATP-proton motive force interconversion

IDP01018
(show subtarget assignments)

1

expressed

STM2894

16766200

invC

ATP synthase SpaL

431

Conserved Gene / Pathway

Phase 2: March 2008

2OBL

38.7%

Salmonella enterica

Transport and binding proteins

Other

IDP01859
(show subtarget assignments)

1

cloned

lmo2558

16804596

ami

autolysin, amidase [Listeria monocytogen...

917

Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838

Phase 3: June 2008

1M9S

14.7%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP05248
(show subtarget assignments)

1

cloned

lmo2691

16804728

-

autolysin [Listeria monocytogenes EGD-e]...

590

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

16.1%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01989
(show subtarget assignments)

1

purified

STM2646

16765966

yfiD

autonomous glycyl radical cofactor GrcA ...

127

Conserved; Drug target functions

Phase 3: June 2008

1CM5

38.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP91511
(show subtarget assignments)

8

cloned

VV2_0479

27366913

autotransporter adhesin [Vibrio vulnific...

5206

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3EEB

3.7%

Vibrio vulnificus

IDP04035
(show subtarget assignments)

1

in_pdb
3P0R

BAS5262

49188247

azoreductase [Bacillus anthracis str. St...

208

Proposed to be essential proteins

Phase 4: April 2009

3P0R

100%

Bacillus anthracis

IDP90903
(show subtarget assignments)

8

purified

VC0390

15640417

metH

B12-dependent methionine synthase [Vibri...

1226

Predicted Essential

Community Requests

3BUL

33.8%

Vibrio cholerae

IDP02636
(show subtarget assignments)

1

expressed

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP90123
(show subtarget assignments)

8

purified

MPXV_ZAI1979_005_035

68449109

B15R-like protein [Monkeypox virus]

149

similar to VACV-COP-K7R, MPXV-ZAI96-C6R

Community Requests

2K36

94%

Monkeypox virus

IDP01160
(show subtarget assignments)

1

expressed

BA_4774

30259261

bacitracin ABC transporter, ATP-binding ...

307

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

25.7%

Bacillus anthracis

Transport and binding proteins

Other

IDP04245
(show subtarget assignments)

1

cloned

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP00025
(show subtarget assignments)

1

soluble

BA_0285

30253779

bacitracin ABC transporter, ATP-binding ...

309

Virulence

Phase 1: October 2007

1OXS

30.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP05181
(show subtarget assignments)

1

soluble

BA_4729

30259221

bacterial extracellular solute-binding p...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1UQW

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05364
(show subtarget assignments)

1

soluble

BA_2881

30257478

bacterial extracellular solute-binding p...

578

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3M8U

19.2%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP00058
(show subtarget assignments)

1

soluble

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91998
(show subtarget assignments)

8

selected

SpneCM_010100004262

298254815

bacteriocin, lactococcin 972 family prot...

99

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP00032
(show subtarget assignments)

1

purified

BA_1221

30255171

bacteriocin O-metyltransferase, putative...

281

Virulence

Phase 1: October 2007

2WK1

36.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01964
(show subtarget assignments)

1

in_pdb
3KWO

Cj1534c

15792842

bacterioferritin [Campylobacter jejuni s...

149

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3KWO

100%

Campylobacter jejuni

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP05576
(show subtarget assignments)

1

cloned

BA_0536

30254062

bcP

bacterioferritin comigratory protein [Ba...

151

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRN

41.7%

Bacillus anthracis

Cellular processes: Detoxification

IDP91463
(show subtarget assignments)

8

expressed

VV1_0079

27363564

bacteriophage phi gp55-like protein [Vib...

159

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91726
(show subtarget assignments)

8

selected

NP_116784

14670388

BAD

bcl2 antagonist of cell death [Homo sapi...

168

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2BZW

14.9%

Homo sapiens

IDP91664
(show subtarget assignments)

8

selected

NP_055232

15193488

BBC3

bcl-2-binding component 3 isoform 4 [Hom...

193

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2ROC

12.4%

Homo sapiens

IDP91727
(show subtarget assignments)

8

selected

NP_619527

20336315

BCL2L11

bcl-2-like protein 11 isoform 1 [Homo sa...

198

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2NL9

13.1%

Homo sapiens

IDP91381
(show subtarget assignments)

8

cloned

VV1_1469

27364853

Beta-galactosidase/beta-glucuronidase [V...

258

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91983
(show subtarget assignments)

8

selected

SpneCM_010100000697

298254118

beta-galactosidase [Streptococcus pneumo...

2233

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3GM8

12.4%

Streptococcus pneumoniae

IDP00463
(show subtarget assignments)

1

soluble

YPO1615

16121883

beta-hexosaminidase

343

Drug Target Function

Phase 2: March 2008

2OXN

55.1%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91429
(show subtarget assignments)

8

purified

VV1_0496

27363960

beta-hexosaminidase [Vibrio vulnificus C...

328

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2OXN

73.5%

Vibrio vulnificus

IDP00699
(show subtarget assignments)

1

in_pdb
3ED6
3FG0

SACOL2628

57286533

betB

betaine aldehyde dehydrogenase

496

Conserved Gene / Pathway

Phase 2: March 2008

3ED6

100%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP91247
(show subtarget assignments)

8

selected

HP0558

2313676

beta ketoacyl-acyl carrier protein synth...

412

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1J3N

49.4%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP91246
(show subtarget assignments)

8

selected

HP0202

2313291

beta-ketoacyl-acyl carrier protein synth...

331

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2EBD

43.8%

Helicobacter pylori

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00303
(show subtarget assignments)

1

purified

CBU_0035

29653398

beta-ketoacyl synthase

424

Drug Target Function

Phase 2: March 2008

3E60

36.8%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00048
(show subtarget assignments)

1

cloned

BA_3330

30257875

beta-lactam antibiotic acylase family pr...

796

Virulence

Phase 1: October 2007

1KEH

22.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00042
(show subtarget assignments)

1

soluble

BA_2507

30257134

bla1

beta-lactamase

309

Virulence

Phase 1: October 2007

3QHY

87.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91877
(show subtarget assignments)

8

selected

CAB89086

7649401

fox-4

beta-lactamase class C [Escherichia coli...

382

potential drug target / Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...

Community Requests

1ZKJ

71.7%

Escherichia coli

IDP00523
(show subtarget assignments)

1

in_pdb
3OZH
3RJU

YPO1224

16121513

ampH

beta-lactamase/D-alanine carboxypeptidas...

388

Conserved Gene / Pathway

Phase 2: March 2008

3OZH

89.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02545
(show subtarget assignments)

1

in_pdb
3P09

FTT0611c

56707736

beta-lactamase [Francisella tularensis s...

287

Drug Target

Phase 3: June 2008

3P09

100%

Francisella tularensis

Cellular processes

Toxin production and resistance

IDP00052
(show subtarget assignments)

1

purified

BA_3500

30258038

bla2

beta-lactamase II

256

Virulence

Phase 1: October 2007

1BC2

81.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91950
(show subtarget assignments)

8

selected

SpneCM_010100006639

298255269

beta-N-acetylhexosaminidase [Streptococc...

1312

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3RPM

35.5%

Streptococcus pneumoniae

IDP05298
(show subtarget assignments)

1

purified

CD2189

126699805

pgmB

beta-phosphoglucomutase [Clostridium dif...

226

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3NAS

46.9%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05309
(show subtarget assignments)

1

purified

CD3128

126700746

pgmB

beta-phosphoglucomutase [Clostridium dif...

223

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3NAS

47.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91632
(show subtarget assignments)

8

purified

BAB35248

13361290

ECs1825

bfpT-regulated chaperone-like protein [E...

196

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LW8

39.8%

Escherichia coli

IDP90139
(show subtarget assignments)

8

cloned

MPXV_ZAI1979_005_182

68449253

bifunctional 21kDa precursor protein of ...

182

virulence, ER resident, similar to VACV-COP-B7R, N-terminal signal peptide, bifu...

Community Requests

Monkeypox virus

IDP02613
(show subtarget assignments)

1

expressed

YPO3530

16123676

cpdB

bifunctional 2',3'-cyclic nucleotide 2'-...

656

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3JYF

40.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP00326
(show subtarget assignments)

0

work_stopped

Cj1607

15792912

ispDF

bifunctional 2-C-methyl-D-erythritol 4-p...

371

Drug Target Function

Phase 2: March 2008

1W55

100%

Campylobacter jejuni

Amino acid biosynthesis

Histidine family

IDP90729
(show subtarget assignments)

8

crystallized

Cj0572

15791932

ribA

bifunctional 3,4-dihydroxy-2-butanone 4-...

339

Predicted Essential

Community Requests

3MGZ

29.5%

Campylobacter jejuni

IDP00804
(show subtarget assignments)

1

expressed

SACOL1787

57286221

bifunctional 3-deoxy-7-phosphoheptulonat...

363

Drug Target Function

Phase 2: March 2008

3NVT

66.9%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP00348
(show subtarget assignments)

1

in_pdb
3TFC
3NVT

lmo1600

16803640

aroA

bifunctional 3-deoxy-7-phosphoheptulonat...

361

Drug Target Function

Phase 2: March 2008

3NVT

100%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP02645
(show subtarget assignments)

1

soluble

STM1749

16765093

adhE

bifunctional acetaldehyde-CoA/alcohol de...

892

Conserved; Essential; Drug target functions

Phase 3: June 2008

3MY7

38.7%

Salmonella enterica

Energy metabolism

Fermentation

IDP00585
(show subtarget assignments)

1

expressed

YPO0116

16120461

metL

bifunctional aspartate kinase II/homoser...

811

Virulence Associated Factor

Phase 2: March 2008

1EBF

15.5%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP91292
(show subtarget assignments)

8

selected

SPA2526

56414632

pheA

bifunctional chorismate mutase/prephenat...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

24.9%

Salmonella enterica

IDP00461
(show subtarget assignments)

1

expressed

YPO3285

16123440

tyrA

bifunctional chorismate mutase/prephenat...

373

Conserved Gene / Pathway

Phase 2: March 2008

2PV7

47.2%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP91007
(show subtarget assignments)

8

expressed

y1938

22125830

bifunctional cysteine desulfurase/seleno...

410

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

1I29

69.8%

Yersinia pestis

IDP90898
(show subtarget assignments)

8

soluble

STM0416

16763796

ribD

bifunctional diaminohydroxyphosphoribosy...

367

Predicted Essential

Community Requests

2G6V

89.4%

Salmonella enterica

IDP90906
(show subtarget assignments)

8

purified

YPO3183

16123345

ribD

bifunctional diaminohydroxyphosphoribosy...

369

Predicted Essential

Community Requests

2G6V

71.8%

Yersinia pestis

IDP90567
(show subtarget assignments)

8

in_pdb
3R2E

YPO0648

16120973

folB

bifunctional dihydroneopterin aldolase/d...

119

Predicted Essential

Community Requests

3R2E

100%

Yersinia pestis

IDP05132
(show subtarget assignments)

1

cloned

CD0262

126697834

flhB

bifunctional flagellar biosynthesis prot...

604

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2JLH

7.9%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP90776
(show subtarget assignments)

8

purified

STM2365

16765692

folC

bifunctional folylpolyglutamate synthase...

422

Predicted Essential

Community Requests

1W78

86.7%

Salmonella enterica

IDP90784
(show subtarget assignments)

8

in_pdb
3PYZ
3NRS
3N2A
3QCZ

YPO2769

16122973

folC

bifunctional folylpolyglutamate synthase...

434

Predicted Essential

Community Requests

3N2A

100%

Yersinia pestis

IDP91288
(show subtarget assignments)

8

selected

SPA1153

56413351

trpD

bifunctional glutamine amidotransferase/...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

47.3%

Salmonella enterica

IDP91224
(show subtarget assignments)

8

selected

SF1266

24112662

trpD

bifunctional glutamine amidotransferase/...

531

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1KGZ

46.7%

Shigella flexneri

IDP01050
(show subtarget assignments)

1

cloned

STM3201

16766501

glnE

bifunctional glutamine-synthetase adenyl...

947

Conserved Gene / Pathway

Phase 2: March 2008

3K7D

47.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP02560
(show subtarget assignments)

1

cloned

GBAA0268

47777798

guaA

bifunctional GMP synthase/glutamine amid...

512

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPM

52.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90695
(show subtarget assignments)

8

purified

Cj1248

15792572

guaA

bifunctional GMP synthase/glutamine amid...

511

Predicted Essential

Community Requests

1GPM

51.8%

Campylobacter jejuni

IDP04199
(show subtarget assignments)

1

cloned

CPF_2557

110800712

guaA

bifunctional GMP synthase/glutamine amid...

509

conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

52.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02219
(show subtarget assignments)

1

purified

FTT1019c

56708108

guaA

bifunctional GMP synthase/glutamine amid...

516

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1GPM

61.1%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90256
(show subtarget assignments)

8

purified

SAR0409

49482642

guaA

bifunctional GMP synthase/glutamine amid...

513

(From requestor) Identified potential S. aureus drug target. Would like to devel...

Community Requests

1GPM

51.2%

Staphylococcus aureus

IDP00558
(show subtarget assignments)

1

purified

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90143
(show subtarget assignments)

8

cloned

MPXV_ZAI1979_005_189

68449260

bifunctional IL-1-beta-inhibitor/prevent...

210

contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184

Community Requests

3O4O

29.5%

Monkeypox virus

IDP90144
(show subtarget assignments)

8

soluble

MPXV_ZAI1979_005_189.5

68449261

bifunctional IL-1-beta-inhibitor/prevent...

126

contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184

Community Requests

1G0Y

27.8%

Monkeypox virus

IDP01871
(show subtarget assignments)

1

cloned

FTT1795c

56708783

trpC

bifunctional indole-3-glycerol phosphate...

453

Conserved; Drug target functions

Phase 3: June 2008

1PII

56.1%

Francisella tularensis

Amino acid biosynthesisFatty acid and phospholipid metabolism

Aromatic amino acid familyHistidine family,Biosynthesis

IDP02235
(show subtarget assignments)

1

purified

FTT1105c

56708184

msrA1

bifunctional methionine sulfoxide reduct...

284

Drug Target

Phase 3: June 2008

2GT3

23.2%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP01477
(show subtarget assignments)

1

purified

VC2762

15642755

glmU

bifunctional N-acetylglucosamine-1-phosp...

453

Drug Target Function

Phase 2: March 2008

1HV9

67.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00427
(show subtarget assignments)

1

in_pdb
3FWW

YPO4119

16124227

glmU

bifunctional N-acetylglucosamine-1-phosp...

456

Drug Target Function

Phase 2: March 2008

3FWW

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides