Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01842 (show subtarget assignments)	1	in_pdb 3ROI 3SLH	CBU_0526	29541129	aroA	3-phosphoshikimate 1-carboxyvinyltransfe...	438	Conserved; Drug target functions	Phase 3: June 2008	3ROI	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01840 (show subtarget assignments)	1	soluble	STM2861	16766167	sitA	putative periplasmic binding protein [Sa...	305	Conserved; Drug target functions	Phase 3: June 2008	1XVL	53.4%	Salmonella enterica	Cell envelope	Other

IDP01838 (show subtarget assignments)	1	cloned	STM0941	16764303	ybjY	macrolide transporter subunit MacA [Salm...	372	Conserved; Drug target functions	Phase 3: June 2008	3FPP	79%	Salmonella enterica	Unknown function	General

IDP02073 (show subtarget assignments)	1	expressed	CBU_0418	29541027		4-amino-4-deoxychorismate lyase, putativ...	281	Conserved; Drug target functions	Phase 3: June 2008	3LUL	28.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02069 (show subtarget assignments)	1	purified	CBU_2017	29542571	ubiE	ubiquinone/menaquinone biosynthesis meth...	250	Conserved; Drug target functions	Phase 3: June 2008	3SM3	19.6%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02836 (show subtarget assignments)	1	purified	GBAA4423	47529716	aroQ	3-dehydroquinate dehydratase [Bacillus a...	146	Conserved; Drug target functions	Phase 3: June 2008	1GQO	57.5%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01841 (show subtarget assignments)	1	purified	STM2549	16765869	asrB	anaerobic sulfite reductase subunit B [S...	272	Conserved; Drug target functions	Phase 3: June 2008	1KRH	18.8%	Salmonella enterica	Energy metabolism	Anaerobic

IDP01835 (show subtarget assignments)	1	cloned	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02012 (show subtarget assignments)	1	soluble	STM4233	16767483	ubiC	chorismate pyruvate lyase [Salmonella ty...	165	Conserved; Drug target functions	Phase 3: June 2008	1G1B	86.1%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02823 (show subtarget assignments)	1	soluble	CBU_0382	29540992	ispB	octylprenyl diphosphate synthase-like pr...	332	Conserved; Drug target functions	Phase 3: June 2008	3MZV	44%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02819 (show subtarget assignments)	1	expressed	STM2414	16765738	yfeD	putative negative regulator [Salmonella ...	130	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02815 (show subtarget assignments)	1	soluble	GBAA4880	47530173	argG	argininosuccinate synthase [Bacillus ant...	401	Conserved; Drug target functions	Phase 3: June 2008	1VL2	46.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02814 (show subtarget assignments)	1	cloned	FTT0709	56707828	eno	enolase (2-phosphoglycerate dehydratase)...	456	Conserved; Drug target functions	Phase 3: June 2008	1IYX	60.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02818 (show subtarget assignments)	1	selected	GBAA4027	47529320	pyrC	dihydroorotase [Bacillus anthracis str. ...	428	Conserved; Drug target functions	Phase 3: June 2008	3MPG	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02808 (show subtarget assignments)	1	cloned	STM1084	16764443	yccK	sulfurtransferase TusE [Salmonella typhi...	109	Conserved; Drug target functions	Phase 3: June 2008	1YX3	47.7%	Salmonella enterica	Unknown function	General

IDP02811 (show subtarget assignments)	1	soluble	STM1880	16765222	yebE	putative inner membrane protein [Salmone...	219	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02812 (show subtarget assignments)	1	cloned	FTT1484c	56708523	aceF	dihydrolipoamide acetyltransferase [Fran...	631	Conserved; Drug target functions	Phase 3: June 2008	3DUF	26%	Francisella tularensis	Energy metabolism	Pyruvate dehydrogenase

IDP02788 (show subtarget assignments)	1	expressed	CBU_0140	29540760	ftsA	cell division protein FtsA [Coxiella bur...	410	Conserved; Drug target functions	Phase 3: June 2008	1E4F	22.9%	Coxiella burnetii	Cellular processes	Cell division

IDP02789 (show subtarget assignments)	1	cloned	CBU_0141	29540761	ftsZ	cell division protein FtsZ [Coxiella bur...	386	Conserved; Drug target functions	Phase 3: June 2008	2VAW	63.4%	Coxiella burnetii	Cellular processes	Cell division

IDP02783 (show subtarget assignments)	1	expressed	FTT0425c	56707572	asd	aspartate-semialdehyde dehydrogenase [Fr...	364	Conserved; Drug target functions	Phase 3: June 2008	1NWC	50%	Francisella tularensis	Amino acid biosynthesis	Aspartate family

IDP02831 (show subtarget assignments)	1	purified	GBAA4686	47529986	maf	Maf-like protein [Bacillus anthracis str...	191	Conserved; Drug target functions	Phase 3: June 2008	1EX2	53.4%	Bacillus anthracis	Cellular processes	Cell division

IDP02779 (show subtarget assignments)	1	purified	FTT1405c	56708453	gloB	hydroxyacylglutathione hydrolase [Franci...	252	Conserved; Drug target functions	Phase 3: June 2008	2QED	34.1%	Francisella tularensis	Energy metabolism	Other

IDP02778 (show subtarget assignments)	1	cloned	CBU_0056	29540679		outer membrane protein TolC, putative [C...	616	Conserved; Drug target functions	Phase 3: June 2008	2VDD	27.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02780 (show subtarget assignments)	1	soluble	GBAA0507	47525777		NAD-dependent epimerase/dehydratase fami...	321	Conserved; Drug target functions	Phase 3: June 2008	2B69	35.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01998 (show subtarget assignments)	1	cloned	CBU_0744	29541344		Hpr(Ser) kinase/phosphatase [Coxiella bu...	192	Conserved; Drug target functions	Phase 3: June 2008	3TQF	92.7%	Coxiella burnetii	Signal transduction	PTS

IDP02777 (show subtarget assignments)	1	soluble	GBAA4698	47529997	hemA	glutamyl-tRNA reductase [Bacillus anthra...	444	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	27.3%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02794 (show subtarget assignments)	1	purified	FTT0477c	56707619	birA	transcription repressor BirA [Francisell...	260	Conserved; Drug target functions	Phase 3: June 2008	1BIA	25.8%	Francisella tularensis	Protein fate	Protein modification and repair

IDP02764 (show subtarget assignments)	1	expressed	CBU_0525	29541128	serC	phosphoserine aminotransferase [Coxiella...	360	Conserved; Drug target functions	Phase 3: June 2008	3QBO	53.6%	Coxiella burnetii	Amino acid biosynthesis	Serine family

IDP02762 (show subtarget assignments)	1	cloned	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02771 (show subtarget assignments)	1	in_pdb 3N8H 3QTT	FTT1390	56708439	panC	pantoate-beta-alanine ligase [Francisell...	261	Conserved; Drug target functions	Phase 3: June 2008	3N8H	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02757 (show subtarget assignments)	1	cloned	STM2484	16765804		hypothetical protein STM2484 [Salmonella...	66	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01824 (show subtarget assignments)	1	cloned	STM3197	16766497	glgS	glycogen synthesis protein GlgS [Salmone...	69	Conserved; Drug target functions	Phase 3: June 2008	1RRZ	73.9%	Salmonella enterica	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02760 (show subtarget assignments)	1	crystallized	FTT1367c	56708420	pgk	phosphogylcerate kinase [Francisella tul...	392	Conserved; Drug target functions	Phase 3: June 2008	1ZMR	62.8%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02773 (show subtarget assignments)	1	crystallized	FTT1389	56708438	panB	3-methyl-2-oxobutanoate hydroxymethyltra...	264	Conserved; Drug target functions	Phase 3: June 2008	1O66	41.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01822 (show subtarget assignments)	1	cloned	FTT0317	56707470	uppS	undecaprenyl pyrophosphate synthetase [F...	257	Conserved; Drug target functions	Phase 3: June 2008	1JP3	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01825 (show subtarget assignments)	1	cloned	STM2265	16765593	ada	O6-methylguanine-DNA methyltransferase/t...	353	Conserved; Drug target functions	Phase 3: June 2008	1SFE	37.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01999 (show subtarget assignments)	1	soluble	FTT0942c	56708039	folK	2-amino-4-hydroxy-6-hydroxymethyldihydro...	421	Conserved; Drug target functions	Phase 3: June 2008	3MCM	99.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01819 (show subtarget assignments)	1	cloned	STM1145	16764501	csgC	putative autoagglutination protein [Salm...	108	Conserved; Drug target functions	Phase 3: June 2008	2Y2T	64.8%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01820 (show subtarget assignments)	1	cloned	GBAA5463	47530777	thiC	thiamine biosynthesis protein ThiC [Baci...	586	Conserved; Drug target functions	Phase 3: June 2008	3EPM	66.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP01826 (show subtarget assignments)	1	in_pdb 3LAY	STM4172	16767426	zraP	zinc resistance protein [Salmonella typh...	151	Conserved; Drug target functions	Phase 3: June 2008	3LAY	100%	Salmonella enterica	Unknown function	General

IDP02756 (show subtarget assignments)	1	expressed	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02775 (show subtarget assignments)	1	purified	GBAA4028	47529321	pyrB	aspartate carbamoyltransferase catalytic...	304	Conserved; Drug target functions	Phase 3: June 2008	3R7D	61.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02749 (show subtarget assignments)	1	soluble	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP01816 (show subtarget assignments)	1	purified	STM3193	16766493		putative disulfide bond formation protei...	223	Conserved; Drug target functions	Phase 3: June 2008	3L9U	89.2%	Salmonella enterica	Protein synthesis	Translation factors

IDP02832 (show subtarget assignments)	1	expressed	FTT1518	56708554	ogt	methylated-DNA--protein-cysteine methylt...	190	Conserved; Drug target functions	Phase 3: June 2008	1SFE	28.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy	Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP01817 (show subtarget assignments)	1	cloned	STM1143	16764499	csgB	curlin minor subunit [Salmonella typhimu...	151	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Pathogenesis

IDP01815 (show subtarget assignments)	1	soluble	CBU_1382	29541947	uppS	undecaprenyl diphosphate synthase [Coxie...	237	Conserved; Drug target functions	Phase 3: June 2008	1JP3	49.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02755 (show subtarget assignments)	1	expressed	FTT1365c	56708418	fbaB	fructose-1,6-bisphosphate aldolase [Fran...	354	Conserved; Drug target functions	Phase 3: June 2008	3GAK	46.6%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02063 (show subtarget assignments)	1	purified	CBU_0387	29540997	cgtA	GTP-binding protein, GTP1/Obg family [Co...	339	Conserved; Drug target functions	Phase 3: June 2008	1UDX	46.3%	Coxiella burnetii	Unknown function	General

IDP02776 (show subtarget assignments)	1	expressed	CBU_1266	29541836	lipA	lipoic acid synthetase [Coxiella burneti...	315	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP02731 (show subtarget assignments)	1	expressed	CBU_0124	29540744	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	446	Conserved; Drug target functions	Phase 3: June 2008	1GG4	43.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02732 (show subtarget assignments)	1	cloned	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP01810 (show subtarget assignments)	1	cloned	STM3187	16766487	ygiB	hypothetical protein STM3187 [Salmonella...	223	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01811 (show subtarget assignments)	1	expressed	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP01992 (show subtarget assignments)	1	expressed	STM3822	16767107	torA	trimethylamine N-oxide reductase subunit...	850	Conserved; Drug target functions	Phase 3: June 2008	1TMO	50.5%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02721 (show subtarget assignments)	1	soluble	GBAA4007	47529300	coaBC	bifunctional phosphopantothenoylcysteine...	401	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02723 (show subtarget assignments)	1	cloned	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP02733 (show subtarget assignments)	1	in_pdb 3M5P 3Q7I 3Q88 3LJK	FTT1315c	56708372	pgi	glucose-6-phosphate isomerase [Francisel...	540	Conserved; Drug target functions	Phase 3: June 2008	3LJK	99.8%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01995 (show subtarget assignments)	1	soluble	CBU_2012	29542567	hslU	heat shock protein HslVU, ATPase subunit...	447	Conserved; Drug target functions	Phase 3: June 2008	1DO0	67.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP01812 (show subtarget assignments)	1	cloned	FTT1764c	56708759		ferredoxin [Francisella tularensis subsp...	107	Conserved; Drug target functions	Phase 3: June 2008	1A6L	64.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP02715 (show subtarget assignments)	1	cloned	STM3573	16766859	yhhL	hypothetical protein STM3573 [Salmonella...	90	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01802 (show subtarget assignments)	1	crystallized	FTT0062	56707241	atpA	F0F1 ATP synthase subunit alpha [Francis...	513	Conserved; Drug target functions	Phase 3: June 2008	3OAA	71%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01805 (show subtarget assignments)	1	soluble	CBU_1084	29541658		sensory box sensor histidine kinase/resp...	683	Conserved; Drug target functions	Phase 3: June 2008	2C2A	12.4%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01803 (show subtarget assignments)	1	soluble	CBU_0646	29541247	ribE	riboflavin synthase, alpha subunit [Coxi...	202	Conserved; Drug target functions	Phase 3: June 2008	1I8D	37.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02707 (show subtarget assignments)	1	cloned	STM3237	16766536	yhaL	putative cytoplasmic protein [Salmonella...	54	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02696 (show subtarget assignments)	1	soluble	GBAA2773	47528064	acoL	dihydrolipoamide dehydrogenase [Bacillus...	459	Conserved; Drug target functions	Phase 3: June 2008	2QAE	40.6%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02694 (show subtarget assignments)	1	soluble	STM1325	16764676	ydiZ	putative cytoplasmic protein [Salmonella...	96	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02714 (show subtarget assignments)	1	purified	FTT1231	56708293	mesJ	PP-loop family protein [Francisella tula...	398	Conserved; Drug target functions	Phase 3: June 2008	1NI5	27.3%	Francisella tularensis	Cellular processes	Cell division

IDP01813 (show subtarget assignments)	1	purified	GBAA1253	47526519	trpB	tryptophan synthase subunit beta [Bacill...	397	Conserved; Drug target functions	Phase 3: June 2008	1X1Q	63%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01797 (show subtarget assignments)	1	cloned	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01996 (show subtarget assignments)	1	purified	STM3136	16766436		putative D-mannonate oxidoreductase [Sal...	490	Conserved; Drug target functions	Phase 3: June 2008	1LJ8	40.6%	Salmonella enterica	Energy metabolism	Other

IDP02684 (show subtarget assignments)	1	cloned	FTT0405	56707554	lolD	lipoprotein releasing system, subunit D,...	231	Conserved; Drug target functions	Phase 3: June 2008	1F3O	44.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02692 (show subtarget assignments)	1	expressed	FTT0503c	56707642	sucD	succinyl-CoA synthetase, alpha subunit [...	290	Conserved; Drug target functions	Phase 3: June 2008	1CQI	75.5%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02681 (show subtarget assignments)	1	soluble	STM3682	16766967	selB	selenocysteinyl-tRNA-specific translatio...	616	Conserved; Drug target functions	Phase 3: June 2008	1D8T	19%	Salmonella enterica	Protein synthesis	Translation factors

IDP01793 (show subtarget assignments)	1	in_pdb 3QDN	STM0504	16763884	ybbN	putative thioredoxin protein [Salmonella...	284	Conserved; Drug target functions	Phase 3: June 2008	3QDN	100%	Salmonella enterica	Energy metabolism	Electron transport

IDP02682 (show subtarget assignments)	1	purified	CBU_1502	29542061	era	GTP-binding protein Era [Coxiella burnet...	295	Conserved; Drug target functions	Phase 3: June 2008	1EGA	51.2%	Coxiella burnetii	Regulatory functions	RNA interactions

IDP02060 (show subtarget assignments)	1	expressed	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01814 (show subtarget assignments)	1	expressed	STM1753	16765097	hnr	response regulator of RpoS [Salmonella t...	337	Conserved; Drug target functions	Phase 3: June 2008	3EOD	35.3%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02673 (show subtarget assignments)	1	expressed	STM4466	16767711		carbamate kinase [Salmonella typhimurium...	310	Conserved; Drug target functions	Phase 3: June 2008	1E19	45.5%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP01786 (show subtarget assignments)	1	expressed	CBU_0502	29541107		hydrolase, putative [Coxiella burnetii R...	225	Conserved; Drug target functions	Phase 3: June 2008	2GZX	44.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP02021 (show subtarget assignments)	1	cloned	CBU_1240	29541810	gcp	O-sialoglycoprotein endopeptidase [Coxie...	339	Conserved; Drug target functions	Phase 3: June 2008	2IVN	36%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02675 (show subtarget assignments)	1	expressed	CBU_1842	29542398		GTP-binding protein YchF [Coxiella burne...	363	Conserved; Drug target functions	Phase 3: June 2008	1JAL	65.3%	Coxiella burnetii	Unknown function	General

IDP01784 (show subtarget assignments)	1	expressed	STM1383	16764733	ttrA	tetrathionate reductase complex subunit ...	1020	Conserved; Drug target functions	Phase 3: June 2008	2IVF	18.1%	Salmonella enterica	Energy metabolism	Electron transport

IDP01780 (show subtarget assignments)	1	purified	STM0784	16764148	ybhA	phosphotransferase [Salmonella typhimuri...	272	Conserved; Drug target functions	Phase 3: June 2008	2PQ0	30.5%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP01785 (show subtarget assignments)	1	expressed	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02665 (show subtarget assignments)	1	cloned	FTT0469	56707611	ksgA	dimethyladenosine transferase [Francisel...	262	Conserved; Drug target functions	Phase 3: June 2008	3TQS	40.8%	Francisella tularensis	Cellular processesProtein synthesis	Toxin production and resistancetRNA and rRNA base modification

IDP02670 (show subtarget assignments)	1	cloned	GBAA4353	47529649	argB	acetylglutamate kinase [Bacillus anthrac...	255	Conserved; Drug target functions	Phase 3: June 2008	2BTY	43.1%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02693 (show subtarget assignments)	1	crystallized	FTT0185	56707350	ddlB	D-alanine--D-alanine ligase B [Francisel...	296	Conserved; Drug target functions	Phase 3: June 2008	3V4Z	43.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02833 (show subtarget assignments)	1	cloned	GBAA4561	47529857	aroE	shikimate 5-dehydrogenase [Bacillus anth...	308	Conserved; Drug target functions	Phase 3: June 2008	2EGG	49.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP02652 (show subtarget assignments)	1	expressed	GBAA1422	47526694	leuC	isopropylmalate isomerase large subunit ...	464	Conserved; Drug target functions	Phase 3: June 2008	2B3X	22%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02653 (show subtarget assignments)	1	purified	STM2840	16766146		anaerobic nitric oxide reductase flavoru...	479	Conserved; Drug target functions	Phase 3: June 2008	1YCF	33.8%	Salmonella enterica	Energy metabolism	Electron transport

IDP02061 (show subtarget assignments)	1	cloned	CBU_0147	29540767	secA	preprotein translocase, SecA subunit [Co...	913	Conserved; Drug target functions	Phase 3: June 2008	2FSF	59.9%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01997 (show subtarget assignments)	1	cloned	STM4310	16767560		putative inner membrane protein [Salmone...	301	Conserved; Drug target functions	Phase 3: June 2008	3QQZ	29.6%	Salmonella enterica	Unknown function	General

IDP02062 (show subtarget assignments)	1	soluble	CBU_1357	29541922	csdB	selenocysteine lyase [Coxiella burnetii ...	405	Conserved; Drug target functions	Phase 3: June 2008	1I29	50.9%	Coxiella burnetii	Central intermediary metabolism	Other

IDP01769 (show subtarget assignments)	1	soluble	STM2532	16765852		putative inner membrane lipoprotein [Sal...	1644	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01777 (show subtarget assignments)	1	cloned	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02028 (show subtarget assignments)	1	in_pdb 3Q7H	CBU_0738	29541338	clpP	ATP-dependent Clp protease, proteolytic ...	195	Conserved; Drug target functions	Phase 3: June 2008	3Q7H	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02644 (show subtarget assignments)	1	purified	FTT0074	56707253	sdhA	succinate dehydrogenase, catalytic and N...	597	Conserved; Drug target functions	Phase 3: June 2008	1NEK	61.4%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02648 (show subtarget assignments)	1	soluble	FTT0064	56707243	atpD	F0F1 ATP synthase subunit beta [Francise...	458	Conserved; Drug target functions	Phase 3: June 2008	3OAA	81.3%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP01758 (show subtarget assignments)	1	expressed	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01842
(show subtarget assignments)

1

in_pdb
3ROI
3SLH

CBU_0526

29541129

aroA

3-phosphoshikimate 1-carboxyvinyltransfe...

438

Conserved; Drug target functions

Phase 3: June 2008

3ROI

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01840
(show subtarget assignments)

1

soluble

STM2861

16766167

sitA

putative periplasmic binding protein [Sa...

305

Conserved; Drug target functions

Phase 3: June 2008

1XVL

53.4%

Salmonella enterica

Cell envelope

Other

IDP01838
(show subtarget assignments)

1

cloned

STM0941

16764303

ybjY

macrolide transporter subunit MacA [Salm...

372

Conserved; Drug target functions

Phase 3: June 2008

3FPP

79%

Salmonella enterica

Unknown function

General

IDP02073
(show subtarget assignments)

1

expressed

CBU_0418

29541027

4-amino-4-deoxychorismate lyase, putativ...

281

Conserved; Drug target functions

Phase 3: June 2008

3LUL

28.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02069
(show subtarget assignments)

1

purified

CBU_2017

29542571

ubiE

ubiquinone/menaquinone biosynthesis meth...

250

Conserved; Drug target functions

Phase 3: June 2008

3SM3

19.6%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02836
(show subtarget assignments)

1

purified

GBAA4423

47529716

aroQ

3-dehydroquinate dehydratase [Bacillus a...

146

Conserved; Drug target functions

Phase 3: June 2008

1GQO

57.5%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01841
(show subtarget assignments)

1

purified

STM2549

16765869

asrB

anaerobic sulfite reductase subunit B [S...

272

Conserved; Drug target functions

Phase 3: June 2008

1KRH

18.8%

Salmonella enterica

Energy metabolism

Anaerobic

IDP01835
(show subtarget assignments)

1

cloned

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02012
(show subtarget assignments)

1

soluble

STM4233

16767483

ubiC

chorismate pyruvate lyase [Salmonella ty...

165

Conserved; Drug target functions

Phase 3: June 2008

1G1B

86.1%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02823
(show subtarget assignments)

1

soluble

CBU_0382

29540992

ispB

octylprenyl diphosphate synthase-like pr...

332

Conserved; Drug target functions

Phase 3: June 2008

3MZV

44%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02819
(show subtarget assignments)

1

expressed

STM2414

16765738

yfeD

putative negative regulator [Salmonella ...

130

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02815
(show subtarget assignments)

1

soluble

GBAA4880

47530173

argG

argininosuccinate synthase [Bacillus ant...

401

Conserved; Drug target functions

Phase 3: June 2008

1VL2

46.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02814
(show subtarget assignments)

1

cloned

FTT0709

56707828

eno

enolase (2-phosphoglycerate dehydratase)...

456

Conserved; Drug target functions

Phase 3: June 2008

1IYX

60.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02818
(show subtarget assignments)

1

selected

GBAA4027

47529320

pyrC

dihydroorotase [Bacillus anthracis str. ...

428

Conserved; Drug target functions

Phase 3: June 2008

3MPG

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02808
(show subtarget assignments)

1

cloned

STM1084

16764443

yccK

sulfurtransferase TusE [Salmonella typhi...

109

Conserved; Drug target functions

Phase 3: June 2008

1YX3

47.7%

Salmonella enterica

Unknown function

General

IDP02811
(show subtarget assignments)

1

soluble

STM1880

16765222

yebE

putative inner membrane protein [Salmone...

219

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02812
(show subtarget assignments)

1

cloned

FTT1484c

56708523

aceF

dihydrolipoamide acetyltransferase [Fran...

631

Conserved; Drug target functions

Phase 3: June 2008

3DUF

26%

Francisella tularensis

Energy metabolism

Pyruvate dehydrogenase

IDP02788
(show subtarget assignments)

1

expressed

CBU_0140

29540760

ftsA

cell division protein FtsA [Coxiella bur...

410

Conserved; Drug target functions

Phase 3: June 2008

1E4F

22.9%

Coxiella burnetii

Cellular processes

Cell division

IDP02789
(show subtarget assignments)

1

cloned

CBU_0141

29540761

ftsZ

cell division protein FtsZ [Coxiella bur...

386

Conserved; Drug target functions

Phase 3: June 2008

2VAW

63.4%

Coxiella burnetii

Cellular processes

Cell division

IDP02783
(show subtarget assignments)

1

expressed

FTT0425c

56707572

asd

aspartate-semialdehyde dehydrogenase [Fr...

364

Conserved; Drug target functions

Phase 3: June 2008

1NWC

50%

Francisella tularensis

Amino acid biosynthesis

Aspartate family

IDP02831
(show subtarget assignments)

1

purified

GBAA4686

47529986

maf

Maf-like protein [Bacillus anthracis str...

191

Conserved; Drug target functions

Phase 3: June 2008

1EX2

53.4%

Bacillus anthracis

Cellular processes

Cell division

IDP02779
(show subtarget assignments)

1

purified

FTT1405c

56708453

gloB

hydroxyacylglutathione hydrolase [Franci...

252

Conserved; Drug target functions

Phase 3: June 2008

2QED

34.1%

Francisella tularensis

Energy metabolism

Other

IDP02778
(show subtarget assignments)

1

cloned

CBU_0056

29540679

outer membrane protein TolC, putative [C...

616

Conserved; Drug target functions

Phase 3: June 2008

2VDD

27.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02780
(show subtarget assignments)

1

soluble

GBAA0507

47525777

NAD-dependent epimerase/dehydratase fami...

321

Conserved; Drug target functions

Phase 3: June 2008

2B69

35.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01998
(show subtarget assignments)

1

cloned

CBU_0744

29541344

Hpr(Ser) kinase/phosphatase [Coxiella bu...

192

Conserved; Drug target functions

Phase 3: June 2008

3TQF

92.7%

Coxiella burnetii

Signal transduction

PTS

IDP02777
(show subtarget assignments)

1

soluble

GBAA4698

47529997

hemA

glutamyl-tRNA reductase [Bacillus anthra...

444

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

27.3%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02794
(show subtarget assignments)

1

purified

FTT0477c

56707619

birA

transcription repressor BirA [Francisell...

260

Conserved; Drug target functions

Phase 3: June 2008

1BIA

25.8%

Francisella tularensis

Protein fate

Protein modification and repair

IDP02764
(show subtarget assignments)

1

expressed

CBU_0525

29541128

serC

phosphoserine aminotransferase [Coxiella...

360

Conserved; Drug target functions

Phase 3: June 2008

3QBO

53.6%

Coxiella burnetii

Amino acid biosynthesis

Serine family

IDP02762
(show subtarget assignments)

1

cloned

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02771
(show subtarget assignments)

1

in_pdb
3N8H
3QTT

FTT1390

56708439

panC

pantoate-beta-alanine ligase [Francisell...

261

Conserved; Drug target functions

Phase 3: June 2008

3N8H

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02757
(show subtarget assignments)

1

cloned

STM2484

16765804

hypothetical protein STM2484 [Salmonella...

66

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01824
(show subtarget assignments)

1

cloned

STM3197

16766497

glgS

glycogen synthesis protein GlgS [Salmone...

69

Conserved; Drug target functions

Phase 3: June 2008

1RRZ

73.9%

Salmonella enterica

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02760
(show subtarget assignments)

1

crystallized

FTT1367c

56708420

pgk

phosphogylcerate kinase [Francisella tul...

392

Conserved; Drug target functions

Phase 3: June 2008

1ZMR

62.8%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02773
(show subtarget assignments)

1

crystallized

FTT1389

56708438

panB

3-methyl-2-oxobutanoate hydroxymethyltra...

264

Conserved; Drug target functions

Phase 3: June 2008

1O66

41.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01822
(show subtarget assignments)

1

cloned

FTT0317

56707470

uppS

undecaprenyl pyrophosphate synthetase [F...

257

Conserved; Drug target functions

Phase 3: June 2008

1JP3

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01825
(show subtarget assignments)

1

cloned

STM2265

16765593

ada

O6-methylguanine-DNA methyltransferase/t...

353

Conserved; Drug target functions

Phase 3: June 2008

1SFE

37.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01999
(show subtarget assignments)

1

soluble

FTT0942c

56708039

folK

2-amino-4-hydroxy-6-hydroxymethyldihydro...

421

Conserved; Drug target functions

Phase 3: June 2008

3MCM

99.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01819
(show subtarget assignments)

1

cloned

STM1145

16764501

csgC

putative autoagglutination protein [Salm...

108

Conserved; Drug target functions

Phase 3: June 2008

2Y2T

64.8%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01820
(show subtarget assignments)

1

cloned

GBAA5463

47530777

thiC

thiamine biosynthesis protein ThiC [Baci...

586

Conserved; Drug target functions

Phase 3: June 2008

3EPM

66.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP01826
(show subtarget assignments)

1

in_pdb
3LAY

STM4172

16767426

zraP

zinc resistance protein [Salmonella typh...

151

Conserved; Drug target functions

Phase 3: June 2008

3LAY

100%

Salmonella enterica

Unknown function

General

IDP02756
(show subtarget assignments)

1

expressed

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02775
(show subtarget assignments)

1

purified

GBAA4028

47529321

pyrB

aspartate carbamoyltransferase catalytic...

304

Conserved; Drug target functions

Phase 3: June 2008

3R7D

61.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02749
(show subtarget assignments)

1

soluble

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP01816
(show subtarget assignments)

1

purified

STM3193

16766493

putative disulfide bond formation protei...

223

Conserved; Drug target functions

Phase 3: June 2008

3L9U

89.2%

Salmonella enterica

Protein synthesis

Translation factors

IDP02832
(show subtarget assignments)

1

expressed

FTT1518

56708554

ogt

methylated-DNA--protein-cysteine methylt...

190

Conserved; Drug target functions

Phase 3: June 2008

1SFE

28.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy

Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP01817
(show subtarget assignments)

1

cloned

STM1143

16764499

csgB

curlin minor subunit [Salmonella typhimu...

151

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Pathogenesis

IDP01815
(show subtarget assignments)

1

soluble

CBU_1382

29541947

uppS

undecaprenyl diphosphate synthase [Coxie...

237

Conserved; Drug target functions

Phase 3: June 2008

1JP3

49.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02755
(show subtarget assignments)

1

expressed

FTT1365c

56708418

fbaB

fructose-1,6-bisphosphate aldolase [Fran...

354

Conserved; Drug target functions

Phase 3: June 2008

3GAK

46.6%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02063
(show subtarget assignments)

1

purified

CBU_0387

29540997

cgtA

GTP-binding protein, GTP1/Obg family [Co...

339

Conserved; Drug target functions

Phase 3: June 2008

1UDX

46.3%

Coxiella burnetii

Unknown function

General

IDP02776
(show subtarget assignments)

1

expressed

CBU_1266

29541836

lipA

lipoic acid synthetase [Coxiella burneti...

315

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP02731
(show subtarget assignments)

1

expressed

CBU_0124

29540744

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

446

Conserved; Drug target functions

Phase 3: June 2008

1GG4

43.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02732
(show subtarget assignments)

1

cloned

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP01810
(show subtarget assignments)

1

cloned

STM3187

16766487

ygiB

hypothetical protein STM3187 [Salmonella...

223

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01811
(show subtarget assignments)

1

expressed

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP01992
(show subtarget assignments)

1

expressed

STM3822

16767107

torA

trimethylamine N-oxide reductase subunit...

850

Conserved; Drug target functions

Phase 3: June 2008

1TMO

50.5%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02721
(show subtarget assignments)

1

soluble

GBAA4007

47529300

coaBC

bifunctional phosphopantothenoylcysteine...

401

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02723
(show subtarget assignments)

1

cloned

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP02733
(show subtarget assignments)

1

in_pdb
3M5P
3Q7I
3Q88
3LJK

FTT1315c

56708372

pgi

glucose-6-phosphate isomerase [Francisel...

540

Conserved; Drug target functions

Phase 3: June 2008

3LJK

99.8%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01995
(show subtarget assignments)

1

soluble

CBU_2012

29542567

hslU

heat shock protein HslVU, ATPase subunit...

447

Conserved; Drug target functions

Phase 3: June 2008

1DO0

67.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP01812
(show subtarget assignments)

1

cloned

FTT1764c

56708759

ferredoxin [Francisella tularensis subsp...

107

Conserved; Drug target functions

Phase 3: June 2008

1A6L

64.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP02715
(show subtarget assignments)

1

cloned

STM3573

16766859

yhhL

hypothetical protein STM3573 [Salmonella...

90

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01802
(show subtarget assignments)

1

crystallized

FTT0062

56707241

atpA

F0F1 ATP synthase subunit alpha [Francis...

513

Conserved; Drug target functions

Phase 3: June 2008

3OAA

71%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01805
(show subtarget assignments)

1

soluble

CBU_1084

29541658

sensory box sensor histidine kinase/resp...

683

Conserved; Drug target functions

Phase 3: June 2008

2C2A

12.4%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01803
(show subtarget assignments)

1

soluble

CBU_0646

29541247

ribE

riboflavin synthase, alpha subunit [Coxi...

202

Conserved; Drug target functions

Phase 3: June 2008

1I8D

37.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02707
(show subtarget assignments)

1

cloned

STM3237

16766536

yhaL

putative cytoplasmic protein [Salmonella...

54

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02696
(show subtarget assignments)

1

soluble

GBAA2773

47528064

acoL

dihydrolipoamide dehydrogenase [Bacillus...

459

Conserved; Drug target functions

Phase 3: June 2008

2QAE

40.6%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02694
(show subtarget assignments)

1

soluble

STM1325

16764676

ydiZ

putative cytoplasmic protein [Salmonella...

96

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02714
(show subtarget assignments)

1

purified

FTT1231

56708293

mesJ

PP-loop family protein [Francisella tula...

398

Conserved; Drug target functions

Phase 3: June 2008

1NI5

27.3%

Francisella tularensis

Cellular processes

Cell division

IDP01813
(show subtarget assignments)

1

purified

GBAA1253

47526519

trpB

tryptophan synthase subunit beta [Bacill...

397

Conserved; Drug target functions

Phase 3: June 2008

1X1Q

63%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01797
(show subtarget assignments)

1

cloned

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01996
(show subtarget assignments)

1

purified

STM3136

16766436

putative D-mannonate oxidoreductase [Sal...

490

Conserved; Drug target functions

Phase 3: June 2008

1LJ8

40.6%

Salmonella enterica

Energy metabolism

Other

IDP02684
(show subtarget assignments)

1

cloned

FTT0405

56707554

lolD

lipoprotein releasing system, subunit D,...

231

Conserved; Drug target functions

Phase 3: June 2008

1F3O

44.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02692
(show subtarget assignments)

1

expressed

FTT0503c

56707642

sucD

succinyl-CoA synthetase, alpha subunit [...

290

Conserved; Drug target functions

Phase 3: June 2008

1CQI

75.5%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02681
(show subtarget assignments)

1

soluble

STM3682

16766967

selB

selenocysteinyl-tRNA-specific translatio...

616

Conserved; Drug target functions

Phase 3: June 2008

1D8T

19%

Salmonella enterica

Protein synthesis

Translation factors

IDP01793
(show subtarget assignments)

1

in_pdb
3QDN

STM0504

16763884

ybbN

putative thioredoxin protein [Salmonella...

284

Conserved; Drug target functions

Phase 3: June 2008

3QDN

100%

Salmonella enterica

Energy metabolism

Electron transport

IDP02682
(show subtarget assignments)

1

purified

CBU_1502

29542061

era

GTP-binding protein Era [Coxiella burnet...

295

Conserved; Drug target functions

Phase 3: June 2008

1EGA

51.2%

Coxiella burnetii

Regulatory functions

RNA interactions

IDP02060
(show subtarget assignments)

1

expressed

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01814
(show subtarget assignments)

1

expressed

STM1753

16765097

hnr

response regulator of RpoS [Salmonella t...

337

Conserved; Drug target functions

Phase 3: June 2008

3EOD

35.3%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02673
(show subtarget assignments)

1

expressed

STM4466

16767711

carbamate kinase [Salmonella typhimurium...

310

Conserved; Drug target functions

Phase 3: June 2008

1E19

45.5%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP01786
(show subtarget assignments)

1

expressed

CBU_0502

29541107

hydrolase, putative [Coxiella burnetii R...

225

Conserved; Drug target functions

Phase 3: June 2008

2GZX

44.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP02021
(show subtarget assignments)

1

cloned

CBU_1240

29541810

gcp

O-sialoglycoprotein endopeptidase [Coxie...

339

Conserved; Drug target functions

Phase 3: June 2008

2IVN

36%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02675
(show subtarget assignments)

1

expressed

CBU_1842

29542398

GTP-binding protein YchF [Coxiella burne...

363

Conserved; Drug target functions

Phase 3: June 2008

1JAL

65.3%

Coxiella burnetii

Unknown function

General

IDP01784
(show subtarget assignments)

1

expressed

STM1383

16764733

ttrA

tetrathionate reductase complex subunit ...

1020

Conserved; Drug target functions

Phase 3: June 2008

2IVF

18.1%

Salmonella enterica

Energy metabolism

Electron transport

IDP01780
(show subtarget assignments)

1

purified

STM0784

16764148

ybhA

phosphotransferase [Salmonella typhimuri...

272

Conserved; Drug target functions

Phase 3: June 2008

2PQ0

30.5%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP01785
(show subtarget assignments)

1

expressed

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02665
(show subtarget assignments)

1

cloned

FTT0469

56707611

ksgA

dimethyladenosine transferase [Francisel...

262

Conserved; Drug target functions

Phase 3: June 2008

3TQS

40.8%

Francisella tularensis

Cellular processesProtein synthesis

Toxin production and resistancetRNA and rRNA base modification

IDP02670
(show subtarget assignments)

1

cloned

GBAA4353

47529649

argB

acetylglutamate kinase [Bacillus anthrac...

255

Conserved; Drug target functions

Phase 3: June 2008

2BTY

43.1%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02693
(show subtarget assignments)

1

crystallized

FTT0185

56707350

ddlB

D-alanine--D-alanine ligase B [Francisel...

296

Conserved; Drug target functions

Phase 3: June 2008

3V4Z

43.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02833
(show subtarget assignments)

1

cloned

GBAA4561

47529857

aroE

shikimate 5-dehydrogenase [Bacillus anth...

308

Conserved; Drug target functions

Phase 3: June 2008

2EGG

49.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP02652
(show subtarget assignments)

1

expressed

GBAA1422

47526694

leuC

isopropylmalate isomerase large subunit ...

464

Conserved; Drug target functions

Phase 3: June 2008

2B3X

22%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02653
(show subtarget assignments)

1

purified

STM2840

16766146

anaerobic nitric oxide reductase flavoru...

479

Conserved; Drug target functions

Phase 3: June 2008

1YCF

33.8%

Salmonella enterica

Energy metabolism

Electron transport

IDP02061
(show subtarget assignments)

1

cloned

CBU_0147

29540767

secA

preprotein translocase, SecA subunit [Co...

913

Conserved; Drug target functions

Phase 3: June 2008

2FSF

59.9%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01997
(show subtarget assignments)

1

cloned

STM4310

16767560

putative inner membrane protein [Salmone...

301

Conserved; Drug target functions

Phase 3: June 2008

3QQZ

29.6%

Salmonella enterica

Unknown function

General

IDP02062
(show subtarget assignments)

1

soluble

CBU_1357

29541922

csdB

selenocysteine lyase [Coxiella burnetii ...

405

Conserved; Drug target functions

Phase 3: June 2008

1I29

50.9%

Coxiella burnetii

Central intermediary metabolism

Other

IDP01769
(show subtarget assignments)

1

soluble

STM2532

16765852

putative inner membrane lipoprotein [Sal...

1644

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01777
(show subtarget assignments)

1

cloned

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02028
(show subtarget assignments)

1

in_pdb
3Q7H

CBU_0738

29541338

clpP

ATP-dependent Clp protease, proteolytic ...

195

Conserved; Drug target functions

Phase 3: June 2008

3Q7H

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02644
(show subtarget assignments)

1

purified

FTT0074

56707253

sdhA

succinate dehydrogenase, catalytic and N...

597

Conserved; Drug target functions

Phase 3: June 2008

1NEK

61.4%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02648
(show subtarget assignments)

1

soluble

FTT0064

56707243

atpD

F0F1 ATP synthase subunit beta [Francise...

458

Conserved; Drug target functions

Phase 3: June 2008

3OAA

81.3%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP01758
(show subtarget assignments)

1

expressed

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

Targets