Target   IDP00167

Stage

in_pdb   : 3FZY

Locus Tag/Selection DB Lookup

VC1451  

NCBI Protein Lookup

gi: 4455065   accession: AAD21057  

Organism

Vibrio cholerae O1 biovar El Tor str. N16961  

Common Name

RTX toxin RtxA  

Gene Name

rtxA  

NCBI Gene Lookup

2613957  

NCBI Annotation

 

TIGR Main Role/Annotations

Cellular processes  

TIGR Sub Role

Pathogenesis  

Comment

 

Selection Phase

Community Requests  

Date Approved

Dec 13, 2007  

Justification for Selection

Virulence  

Justification Codes

 

Priority

8  

Sequence Length

4545  

(Subtargets)

 

pI

4.75  

Molecular Weight

483.4 kDa  

Sequence

(Check Homologs)

MGKPFWRSVE YFFTGNYSAD DGNNNIVAIG FGGQIHAYGG DDHVTVGSIG ATVYTGSGND TVVGGSAYLK VEDSTGHLIV KGAAGYADIN KSGDGNVSFA GAAGGVSIDH LGNHGDVSYG GAAAYNGITR KGLSGNVTFA GAGGYNALWH ETNQGNLSFT GAGAGNKLDR TWSNRYQGSH GDVTFDGAGA ANSISSRVET GNITFRGAGA DNHLVRKGKV GDITLQGAGA SNRIERTHQA EDVYTQTRGN IRFEGVGGYN SLYSDVAHGD IHFSGGGAYN TIIRKGSGND FAKEGMTNAK ADEIVLTKAV MSGSWIGQDH HVTAVKSASE PNTYLFAFAD STYTKINKVQ LRNDPQTGEL KYYSTAWYKE VNHLSNLANQ DISDNGGFTA VNINGAYTLS DLKVEHQQSV TVHAVEKSLT EYEWVTYANG AVIDAKEVSL SDAKMGGHAI YADGTKVDVK AVKSNRQPNT YIYAKVLGPY TKIVVVELAN DPETGALKYQ ARSWYKEGDH TANIANQDIS SATGYNPMGK GGYSLSDLHY SVNAVRSTSE TVADIEEYTD QTLFKPANDS GESSGDVRFN GAGGGNVIKS NVTRGNVHFN GGGIANVILH SSQFGNTEFN GGGAANVIVK SGEEGDLTFR GAGLANVLVH QSEQGKMDVY AGGAVNVLVR LGDGQYLAHL LAYGNISVQK GSGDSRVVML GGYNTHTQIG SGNGLWLAAG GFNVMTQVGK GDVAAVLAGG ANVLTKMGEG ELTSGMLGGA NVITHISNDD QLSNTTAVAL GGANILTKKG KGNTLAVMGG GANVLTHVGD GTTTGVMVGG ANILTKVGNG DTTGILLGVG NVLTHVGDGQ TLGVMGAAGN IFTKVGDGTS IAVMIGAGNI FTHVGEGNAW ALMGGLGNVF TKVGNGDALA LMVAEANVFT HIGDGMSVAL MLAKGNVATK VGNGTTLAAM VGNVNIFTHI GHGSTFAAMI GQANIMTKVG NDLTAALMVG KANIMTHVGD GTSLGLFAGE VNVMTKVGNG TTLAAMFGKA NIMTHVGDGL TGVLALGEAN IVTKLGDDFM GVVAAAKANV VTHVGDATTA AVLAGKGNIL TKVGEGTTVG LLISDVGNVM THVGDGTTIG IAKGKANLIT KVGDGLGVNV TWGQANVFTQ VGDGDRYNFA KGEANLITKV GDGQEVSVVQ GEANIITHVG NGDDYTGAWG KANVITKVGH GQNVVLAKGE ANIVTQVGDG DSFNALWSKG NIVTKVGDGM QVTAAKGQAN ITTTVGNGLN VTAAYGDANI NTKVGDGVSV NVAWGKYNIN TKVGDGLNVA VMKGKANANI HVGDGLNINA SYAQNNVAIK VGNGDFYSLA VASSNTSSNK LSALFDNIKQ TVLGVGGSQA INYLVQGDEA SSSGTHKGRG AIATPEITKL DGFQMDAIKE VSSDLGDSLT GSVTKVDTPD LNKMQHALNV DDSSVQAPNL IVNGDFELGE HGWQSTHGVE ASYAGSVYGV EGEGHGARVT ELDTYTNTSL YQDLANLAQG EVIAVSFDFA KRAGLSNNEG IEVLWNGEVV FSSSXDESAW QQKNLKLTAQ AGSNRIEFKG TGHNDGLGYI LDNVVATSES SQQANAIREH ATQNPAAQNA LSDKERAEAD RQRLEQEKQK QLDAVAGSQS QLESTDQQAL ENNGQAQRDA VKEESEAVTA ELAKLAQGLD VLDGQATHTG ESGDQWRNDF AGGLLDGVQS QLDDAKQLAN DKIAAAKQTL SDNNSKVKES VAKSEAGVAQ GEQNRAGVEQ DIADAQADAE KRKADALAKG KDAQQAESDA HHAVNNAQSR GDRDVQLAEN KANQAQADAQ GAKQNEGDRP DRQGVTGSGL SGNAHSVEGA GETDSHVNTD SQTNADGRFS EGLTEQEQEA LEGATNAVNR LQINAGIRAK NSVSSMTSMF SETNSKSIVV PTKVSPEPER QEVTRRDVRI SGVNLESLSA VQGSQPTGQL ASKSVPGFKS HFASTSIGIE NELSGLVVVL PKNSAQTFGY VHDSQGNPLF MLTKDMNQGG YSNPVGINDI QGVNNWQTHT IELVTYPSEI SDTAAVESRK EAMLWLAKEF TDHINQSNHQ SLPHLVSDDG RFTLVISNSK HLIAAGNGTS IDAQGKTIGM TPSGQQATMA ISAKEFGTSS SPEVRLLESA PWYQAGLRDE FLANAKNTTL DDPATAQNVY AYLTSVYSKT ADLAKEYGIY INDWDPASEG FSPNAQGLTD PKVKNAWSIL PRTKPVRMLE LLSAEDSRYV RQQIAEKLKG TYSESLAKNV FEYFQYGGEV AGHGINNATT GSVQQPEPAI LFEFRSVPSA LSDFVPKTAS TVKVDVKALD HFDSASRKAI ITEVNALVSG SEDFDAWYQE YRASKGQPPV KNPKSSASAN HKAEWLMTQH AEQWAKITAP YTDNHETLTS TKLASNDKEE LHALGETSNL ENNKQQENVA SIINTMLNDM LPFYALRTER NLLVQEGDEG FEVRAWPGTE DKSKTIILED PEDAAQHKAI ERFILANFDN FEQMPDELFL VDNKVISHHE GRTHVLAQKV DGAWQYNATV ELMSVTELLD AANVTGKIRG ESYQQVIDAL TDYHASITEH ADYEPESVEK LLNLRKKIEG YVLGHPDSGR VEAMNSLLNQ VNTRLDEVSL LSVAEQTIQA QNSFSRLYDQ LEAANLKESK HLYLDQNGDF VTKGKGNLAN IDLLGSREAV LEKVKLTVSN EYGQTVADTI FAGLSAKDLA KDGKGVDIAG LNKVHQAIEQ HLSPVSATLY IWKPSDHSAL GHAALQIGQG RTQLEGQAAA DFNQQNYVSW WPLGSKSSNI SNILNVATKD QPDLKLRWSD FSQPAHQNDT LEHDVASEEN DGFGLHDGDI KLKRFIEKLN AAKGIDASFK EASEGYASVL LGNPDMLETT SIPAHVFQPF VEQWNDTSYD MMDVAHRFAQ ELRLQAQRSD DPELLEKRIG NVIRQFAERA LEEIETFKAS QADQGRVFRI NLEGLDVAAM QAEWHRLSND PDARYQLLTK NCSSTVAKVL KAGGADKLIG HTWLPKFGVW TPTELFNFGQ ALQEAQLEIA AKKQSHQVTD VLDALSGNEK PKENVAIEND GTPPRDKESL SPLTRFLNNE LYGDKEARRK IGEITQTLLD HAVEKGESQK ITLQGEAGRL TGYYHQGTAP SEGETSSPSG KVVLFLHGSG SSAEEQASAI RNHYQKQGID MLAVNLRGYG ESDGGPSEKG LYQDARTMFN YLVNDKGIDP SNIIIHGYSM GGPIAADLAR YAAQNGQAVS GLLLDRPMPS MTKAITAHEV ANPAGIVGAI AKAVNGQFSV EKNLEGLPKE TSILLLTDNE GLGNEGEKLR TKLTASGYNV TGEQTFYGHE ASNRLMSQYA DQIVSGLSSS ASVDEDLDQQ GLDTTSTKDQ GISNKNDHLQ VVDSKEALAD GKILHNQNVN SWGPITVTPT TDGGETRFDG QIIVQMENDP VVAKAAANLA GKHAESSVVV QLDSDGNYRV VYGDPSKLDG KLRWQLVGHG RDHSETNNTR LSGYSADELA VKLAKFQQSF NQAENINNKP DHISIVGCSL VSDDKQKGFG HQFINAMDAN GLRVDVSVRS SELAVDEAGR KHTKDANGDW VQKAENNKVS LSWDAQGEVV AKDERIRNGI AEGDIDLSRI GVNNVDEPAR GAIGDNNDVF DAPEKRKPET EVIANSSSSN QFSYSGNIQV NVGEGEFTAV NWGTSNVGIK VGTGGFKSLA FGDNNVMVHI GDGESKHSVD IGGYQALEGA QMFLGNRNVS FNFGHSNDLI LMMDKSIPTP PLVNPFDGAA RISGVLQGIA TSGEGEDWLA AQEQQWTLSG AKKFVKDMSG LDQSSSVDYT TLVELDSQNE RDSRGLKHDA EATLNKQYNQ WLSGNGNSGT SQLSRADKLR QANEKLAFNF AVGGQGADIQ VTTGNWNFMF GDNIQSILDT NLGSLFGLMT QQFTATGQAK TTFTYTPQDL PRQLKNKLLG QLAGVGAETT LADIFGVDYT ASGQIVSRNG QAVDGVAILK EMLEVIGEFS GDQLQAFVDP AKLLDSLKAG IDMGADGIKS FAETHGLKEK APEEEKDNSS VSVNGANVNS AQGATVADGN TETAETQDRA FGFNSLNLPN LFATIFSQDK QKEMKSLVEN LKQNLTADLL NMKEKTFDFL RNSGHLQGDG DINISLGNYN FNWGGDGKDL GAYLGDNNNF WGGRGDDVFY ATGKSNIFTG GEGNDMGVLM GRENMMFGGD GNDTAVVAGR INHVFLGAGD DQSFVFGEGG EIDTGSGRDY VVTSGNFNRV DTGDDQDYSV TIGNNNQVEL GAGNDFANIF GNYNRINAGA GNDVVKLMGY HAVLNGGDGD DHLIATAISK FSQFNGGEGR DLMVLGGYQN TFKGGTDVDS FVVSGDVIDN LVEDIRSEDN IVFNGIDWQK LWFERSGYDX KLSILRDPSN DSDQSKFEHI GSVTFSDYFN GNRAQVVIGM SEKDLSGERE YTMLSDSAID ALVQAMSGFE PQAGDNGFID SLESKSQAAI SMAWSDVVHK KGLMV  

DNA Sequence

ATGGGA AAACCA TTTTGG AGAAGT GTTGAA TACTTC TTCACA GGAAAC TATTCC GCCGAC GATGGA AACAAC AACATT GTAGCC ATTGGT TTTGGG GGACAA ATTCAT GCCTAC GGCGGT GACGAC CACGTC ACTGTT GGATCG ATTGGT GCAACG GTGTAC ACCGGT AGCGGC AACGAT ACGGTC GTGGGC GGCTCT GCCTAT CTCAAA GTGGAA GATTCC ACTGGC CACCTA ATTGTA AAAGGC GCGGCT GGGTAT GCAGAC ATTAAT AAAAGT GGCGAT GGCAAT GTGTCA TTCGCT GGTGCC GCCGGT GGTGTG TCGATT GACCAC TTAGGC AATCAT GGTGAT GTCAGT TACGGC GGTGCC GCGGCT TATAAT GGCATT ACCCGT AAAGGG TTGAGC GGCAAT GTCACC TTTGCA GGCGCG GGGGGA TACAAT GCCCTC TGGCAT GAAACC AACCAA GGGAAC CTGTCT TTTACA GGAGCA GGCGCA GGTAAT AAATTA GACCGT ACTTGG TCTAAC CGTTAT CAAGGC TCGCAT GGCGAT GTGACC TTTGAT GGTGCT GGTGCC GCGAAC AGCATC AGTTCA CGCGTT GAGACA GGTAAC ATCACC TTCCGT GGCGCA GGTGCG GATAAC CATTTA GTCCGT AAAGGC AAAGTG GGCGAT ATTACT CTGCAA GGTGCT GGGGCT TCAAAC CGCATT GAGCGG ACACAT CAGGCC GAAGAT GTCTAC ACGCAA ACCCGC GGCAAT ATTCGT TTTGAA GGTGTG GGTGGT TACAAC AGTCTT TACTCT GATGTG GCTCAT GGTGAC ATTCAT TTCTCG GGTGGC GGTGCG TACAAC ACCATT ATTCGT AAAGGT TCTGGA AATGAC TTTGCG AAAGAA GGCATG ACCAAT GCTAAG GCTGAT GAGATT GTATTA ACTAAG GCCGTG ATGAGT GGCTCA TGGATA GGGCAA GATCAT CATGTC ACAGCG GTGAAA TCGGCT AGCGAG CCTAAT ACATAT CTTTTT GCTTTC GCAGAC TCTACG TATACC AAAATT AACAAA GTACAG TTACGC AATGAT CCTCAA ACTGGA GAACTG AAATAT TACTCT ACGGCT TGGTAT AAAGAG GTTAAC CATCTA AGCAAC TTAGCG AATCAA GACATT TCCGAC AACGGT GGTTTC ACAGCC GTTAAT ATCAAT GGCGCC TACACG CTATCT GACCTC AAAGTT GAACAT CAGCAA TCCGTC ACCGTT CATGCG GTTGAA AAAAGC CTGACT GAATAT GAGTGG GTGACT TACGCC AATGGT GCGGTG ATTGAT GCGAAA GAGGTG TCATTG TCGGAT GCCAAA ATGGGC GGTCAT GCGATT TATGCT GATGGC ACTAAG GTGGAT GTCAAA GCGGTA AAATCC AACCGC CAACCC AACACT TACATT TATGCC AAAGTG CTTGGG CCTTAC ACAAAA ATTGTG GTGGTG GAACTG GCAAAC GATCCC GAAACC GGGGCA CTGAAA TATCAA GCTCGC TCTTGG TATAAA GAAGGT GATCAC ACGGCC AATATA GCCAAC CAAGAT ATTTCA TCTGCA ACTGGG TATAAC CCAATG GGCAAA GGTGGC TACTCG CTCAGT GACTTG CACTAC AGCGTA AACGCC GTTAGA AGTACC AGCGAA ACCGTA GCGGAT ATCGAA GAATAC ACAGAT CAAACC TTGTTT AAACCC GCAAAC GATAGC GGTGAA AGCTCA GGTGAT GTTCGT TTCAAC GGTGCC GGTGGC GGTAAC GTCATC AAATCA AACGTG ACGCGT GGTAAT GTGCAT TTCAAC GGTGGC GGTATT GCCAAC GTGATT TTGCAT AGCTCC CAATTT GGTAAT ACCGAA TTTAAC GGTGGT GGTGCG GCGAAC GTCATT GTCAAA AGTGGC GAAGAA GGGGAT CTCACC TTCCGC GGCGCA GGTTTG GCGAAC GTCTTG GTACAC CAAAGC GAACAA GGCAAG ATGGAT GTGTAC GCGGGC GGTGCG GTAAAC GTGTTG GTTCGC CTTGGC GATGGG CAATAT CTCGCG CATTTA CTGGCT TACGGT AACATT TCAGTC CAAAAA GGCAGT GGTGAT AGTCGC GTCGTG ATGCTC GGTGGC TACAAC ACCCAT ACCCAA ATCGGC TCTGGC AACGGA TTATGG TTGGCC GCGGGC GGTTTC AACGTG ATGACG CAAGTC GGCAAA GGTGAT GTTGCT GCGGTA CTCGCT GGCGGT GCAAAC GTACTG ACCAAA ATGGGT GAGGGT GAACTC ACGTCG GGTATG CTGGGT GGCGCG AACGTA ATAACC CACATC AGCAAT GATGAT CAATTA TCGAAT ACCACG GCTGTG GCACTT GGCGGT GCAAAT ATTCTC ACCAAA AAAGGC AAAGGG AATACC CTTGCG GTGATG GGTGGT GGCGCA AACGTG CTTACC CATGTT GGTGAT GGCACC ACAACG GGTGTC ATGGTC GGCGGT GCGAAC ATTCTC ACCAAA GTAGGT AACGGC GACACG ACCGGC ATTCTG CTTGGC GTTGGC AACGTG CTGACG CATGTG GGTGAT GGCCAA ACCCTT GGCGTA ATGGGC GCGGCG GGTAAC ATCTTC ACCAAA GTGGGT GATGGA ACCTCT ATTGCG GTCATG ATTGGT GCTGGC AACATT TTTACC CATGTG GGGGAA GGGAAT GCTTGG GCGCTG ATGGGC GGCTTG GGTAAC GTCTTT ACCAAA GTAGGC AACGGT GATGCT CTCGCG TTAATG GTAGCA GAAGCC AACGTC TTCACT CACATT GGTGAT GGCATG TCGGTG GCACTG ATGTTA GCCAAA GGCAAC GTTGCG ACAAAA GTGGGT AATGGA ACCACA CTCGCG GCGATG GTGGGG AACGTC AACATC TTTACC CATATT GGTCAT GGCAGC ACGTTT GCGGCG ATGATC GGCCAA GCCAAT ATCATG ACCAAA GTGGGC AATGAT CTCACG GCGGCG CTGATG GTCGGC AAAGCG AACATC ATGACC CATGTT GGCGAT GGTACC AGCCTA GGGCTG TTTGCT GGCGAA GTGAAC GTGATG ACTAAG GTTGGT AACGGC ACCACG TTAGCG GCGATG TTCGGT AAAGCG AACATC ATGACC CATGTC GGTGAT GGCTTA ACCGGT GTACTC GCACTG GGTGAA GCCAAT ATCGTG ACCAAA TTGGGT GATGAT TTCATG GGGGTG GTGGCC GCGGCT AAAGCC AACGTC GTGACT CATGTT GGTGAT GCTACC ACCGCA GCCGTA TTGGCG GGTAAA GGCAAT ATCCTC ACCAAG GTGGGT GAAGGC ACCACG GTAGGG TTGTTG ATTTCC GATGTC GGCAAC GTGATG ACCCAC GTTGGT GACGGC ACCACC ATTGGT ATTGCC AAAGGT AAGGCC AACCTC ATTACC AAAGTC GGTGAT GGTTTA GGTGTT AATGTC ACTTGG GGGCAA GCCAAC GTGTTT ACCCAA GTGGGC GACGGT GATCGC TATAAC TTTGCC AAAGGT GAAGCC AACCTC ATCACC AAAGTG GGTGAT GGCCAA GAAGTC TCCGTG GTGCAA GGTGAA GCCAAC ATCATT ACTCAT GTGGGC AATGGC GACGAC TACACT GGCGCT TGGGGT AAAGCG AACGTC ATTACT AAAGTC GGTCAT GGCCAA AACGTG GTACTG GCAAAA GGTGAA GCCAAC ATTGTT ACTCAA GTGGGT GATGGC GACAGC TTTAAC GCACTT TGGAGC AAAGGC AACATA GTTACC AAAGTG GGCGAT GGTATG CAGGTG ACGGCG GCAAAA GGCCAA GCCAAT ATCACC ACCACC GTGGGT AACGGT TTAAAT GTCACT GCTGCC TACGGC GATGCC AATATC AACACC AAGGTC GGTGAT GGGGTA TCCGTC AACGTC GCTTGG GGCAAA TATAAC ATCAAC ACGAAA GTGGGT GATGGG CTCAAT GTCGCT GTGATG AAGGGC AAAGCT AACGCC AATATT CACGTT GGGGAC GGCCTC AACATC AATGCC TCCTAC GCACAA AACAAC GTCGCC ATCAAA GTCGGT AACGGC GATTTC TATAGT TTAGCG GTGGCA TCGAGC AATACC AGCAGC AACAAG CTCTCT GCCTTG TTTGAT AACATC AAACAA ACCGTA CTCGGT GTCGGT GGCAGC CAAGCC ATCAAC TACTTA GTGCAA GGCGAT GAAGCC TCCTCA TCCGGC ACGCAT AAAGGT CGTGGT GCGATT GCTACA CCTGAA ATCACC AAACTG GATGGT TTCCAA ATGGAT GCCATT AAGGAA GTCAGT TCTGAC CTCGGT GATAGT CTCACG GGCAGC GTGACT AAGGTT GATACT CCTGAT CTCAAC AAGATG CAGCAT GCGCTC AATGTT GATGAT TCTTCC GTTCAA GCTCCG AATCTG ATTGTG AATGGG GATTTT GAGCTG GGCGAA CATGGC TGGCAA TCTACT CATGGG GTTGAA GCCTCT TATGCA GGCAGT GTGTAT GGCGTA GAGGGT GAAGGT CACGGC GCACGT GTGACC GAGCTC GATACT TATACC AACACC AGTCTC TATCAA GATCTG GCTAAT CTAGCG CAAGGT GAAGTT ATTGCG GTGAGC TTTGAT TTTGCA AAACGC GCGGGC CTTTCT AATAAC GAAGGC ATCGAA GTTCTT TGGAAC GGTGAA GTGGTA TTCTCA TCGTCG GKTGAC GAGTCT GCTTGG CAGCAA AAAAAC TTAAAG CTGACC GCGCAG GCTGGC AGTAAC CGTATC GAATTC AAAGGC ACAGGC CACAAT GATGGA CTGGGC TACATC CTAGAT AATGTG GTGGCG ACCTCA GAGTCA TCGCAA CAAGCC AATGCA ATCCGT GAGCAC GCAACG CAAAAC CCAGCA GCGCAG AATGCT CTATCC GATAAA GAGCGT GCAGAA GCGGAT CGCCAA CGTCTT GAACAA GAAAAG CAGAAA CAGCTT GATGCT GTCGCA GGGTCA CAAAGT CAGTTG GAGTCG ACCGAC CAACAA GCGCTA GAAAAT AATGGT CAAGCT CAACGT GATGCG GTGAAA GAAGAG TCGGAA GCCGTG ACCGCC GAGTTG GCAAAA CTGGCG CAAGGT CTCGAT GTGCTT GATGGC CAAGCA ACGCAT ACTGGC GAGTCC GGCGAC CAATGG CGCAAT GATTTT GCCGGT GGTCTG CTCGAT GGCGTT CAAAGC CAGCTC GACGAT GCCAAG CAACTC GCGAAT GACAAG ATTGCT GCAGCG AAGCAG ACCCTG TCTGAC AATAAC AGCAAA GTCAAA GAATCC GTTGCG AAATCT GAAGCG GGTGTG GCACAA GGCGAG CAAAAT CGAGCG GGAGTA GAGCAA GACATT GCTGAT GCTCAA GCCGAT GCTGAA AAACGT AAAGCC GATGCT TTAGCA AAAGGT AAGGAT GCACAA CAAGCG GAATCT GATGCA CATCAT GCGGTA AATAAT GCTCAA TCACGC GGCGAT CGTGAT GTGCAA TTGGCG GAAAAC AAAGCC AACCAA GCACAA GCCGAT GCTCAA GGTGCT AAACAA AACGAA GGTGAT CGTCCT GATCGT CAAGGC GTGACT GGTAGT GGCCTT TCGGGT AATGCT CATAGT GTGGAA GGCGCT GGCGAA ACAGAC AGTCAT GTCAAC ACCGAC AGCCAA ACCAAC GCCGAT GGCCGA TTCAGT GAAGGT TTAACC GAACAA GAGCAA GAAGCG CTAGAA GGTGCG ACCAAC GCAGTG AACCGT TTGCAA ATTAAC GCAGGT ATTCGA GCGAAA AACAGC GTTAGC AGTATG ACTTCT ATGTTC TCTGAA ACAAAT AGCAAG AGCATT GTTGTT CCTACC AAAGTC TCGCCT GAACCA GAGCGC CAAGAA GTGACT CGTAGA GACGTC CGTATC TCAGGG GTGAAC CTCGAA AGTCTA AGTGCG GTACAG GGAAGT CAACCA ACGGGT CAACTG GCTTCG AAAAGT GTCCCC GGATTT AAAAGC CATTTC GCATCG ACATCC ATTGGT ATAGAA AATGAG TTATCC GGTCTG GTGGTG GTTTTA CCGAAA AACTCA GCGCAG ACTTTT GGCTAT GTGCAT GATTCA CAAGGT AACCCA TTGTTC ATGCTA ACCAAG GATATG AATCAA GGTGGT TATAGC AACCCA GTGGGT ATCAAT GATATT CAAGGG GTGAAC AACTGG CAGACG CATACG ATTGAA CTGGTT ACATAT CCTAGT GAAATC AGTGAT ACAGCA GCGGTT GAAAGT CGTAAA GAGGCA ATGCTA TGGCTT GCGAAA GAGTTT ACCGAT CATATC AATCAG TCTAAC CACCAA AGCTTA CCTCAT TTAGTG AGTGAT GACGGT CGTTTC ACTCTG GTTATA TCGAAC TCTAAG CATCTT ATTGCG GCGGGT AACGGA ACCTCT ATTGAT GCACAA GGCAAG ACCATA GGAATG ACCCCT AGTGGC CAACAA GCAACA ATGGCG ATCAGT GCGAAA GAATTT GGTACA AGCTCG TCGCCG GAAGTC AGACTG CTTGAA TCTGCG CCTTGG TATCAA GCAGGG TTGAGA GATGAG TTTTTA GCAAAC GCGAAA AACACC ACGTTG GATGAT CCCGCT ACAGCA CAAAAT GTGTAT GCCTAT CTCACG TCTGTC TATTCA AAAACA GCAGAT TTGGCC AAAGAG TATGGG ATCTAC ATCAAT GATTGG GATCCT GCCTCT GAAGGT TTTTCA CCGAAT GCTCAA GGGTTA ACGGAT CCGAAA GTCAAA AATGCT TGGAGC ATATTG CCAAGA ACTAAA CCCGTT AGAATG CTGGAA CTTCTG AGTGCG GAAGAC TCACGC TACGTA AGGCAA CAAATT GCGGAA AAGCTG AAAGGC ACCTAT TCAGAA AGCCTT GCTAAG AACGTG TTTGAA TACTTC CAATAT GGTGGA GAAGTC GCTGGA CATGGA ATCAAT AATGCG ACGACA GGAAGT GTGCAA CAGCCT GAACCA GCGATC TTATTT GAGTTT CGCAGT GTACCG AGTGCA TTAAGT GACTTT GTACCC AAAACA GCGTCA ACGGTG AAAGTG GATGTT AAGGCA CTCGAT CATTTT GACTCG GCAAGC CGTAAA GCCATC ATTACT GAAGTA AATGCT TTGGTT AGCGGT AGTGAG GATTTC GATGCT TGGTAT CAGGAG TATCGA GCAAGC AAAGGA CAGCCG CCAGTC AAAAAT CCTAAG TCCAGT GCATCC GCCAAT CACAAA GCTGAA TGGTTG ATGACG CAGCAT GCTGAA CAATGG GCGAAA ATTACC GCTCCT TATACT GATAAC CATGAG ACGCTC ACATCT ACCAAG CTTGCT TCTAAC GATAAA GAAGAA TTACAC GCTTTA GGTGAA ACGTCG AATCTA GAGAAT AACAAG CAGCAA GAAAAC GTCGCT TCCATA ATTAAC ACCATG TTAAAT GACATG CTGCCA TTCTAT GCACTT CGTACC GAACGA AATCTA CTGGTA CAAGAA GGAGAT GAAGGC TTCGAA GTGCGT GCTTGG CCAGGA ACCGAA GACAAG AGTAAA ACCATT ATTCTT GAGGAT CCTGAA GACGCG GCTCAG CACAAA GCCATC GAACGC TTCATT CTGGCC AACTTC GATAAT TTCGAA CAAATG CCAGAC GAGCTC TTCTTG GTGGAT AACAAA GTGATT TCACAC CATGAA GGTCGT ACACAT GTGTTG GCGCAA AAAGTC GATGGT GCATGG CAATAC AACGCC ACAGTC GAGCTG ATGTCA GTCACT GAACTA CTGGAT GCGGCG AATGTA ACGGGT AAGATC CGCGGT GAAAGC TATCAG CAAGTG ATCGAC GCATTG ACTGAT TACCAC GCCAGC ATCACT GAGCAC GCAGAT TATGAA CCGGAG TCCGTG GAAAAA CTGCTC AACTTG CGTAAA AAAATT GAAGGT TATGTA CTCGGA CACCCA GACTCA GGCCGT GTTGAA GCGATG AATTCA CTGTTA AATCAG GTGAAT ACGCGT TTAGAT GAAGTT TCACTG CTGTCA GTTGCT GAGCAA ACTATC CAAGCG CAAAAC AGTTTC AGCCGA CTATAT GACCAG CTAGAA GCCGCT AACTTG AAAGAG AGTAAG CACCTT TATCTG GATCAA AATGGT GACTTT GTTACC AAAGGC AAAGGT AATCTT GCCAAT ATCGAT CTGCTA GGTAGC CGCGAA GCTGTG CTTGAA AAAGTG AAGTTA ACAGTA AGTAAC GAGTAC GGTCAA ACCGTT GCGGAT ACAATT TTTGCT GGATTA TCAGCC AAAGAT CTTGCC AAAGAC GGTAAA GGGGTT GATATC GCGGGT TTGAAT AAAGTA CATCAA GCGATT GAACAG CATCTG TCACCT GTCAGC GCCACG TTGTAC ATTTGG AAACCG AGTGAT CATAGC GCGCTA GGTCAT GCCGCA TTGCAA ATAGGC CAAGGT CGCACG CAACTT GAAGGT CAAGCT GCAGCT GATTTT AACCAG CAAAAT TACGTA AGCTGG TGGCCA CTAGGC AGCAAG TCATCC AATATC AGCAAT ATCTTG AATGTG GCCACA AAAGAC CAACCT GATCTT AAGCTG CGCTGG AGCGAC TTCAGT CAACCT GCACAT CAAAAT GACACG CTTGAG CATGAT GTTGCT TCGGAA GAAAAC GATGGC TTTGGT TTGCAT GATGGC GACATT AAGCTG AAACGC TTTATC GAGAAG CTCAAT GCCGCG AAAGGA ATTGAC GCTTCA TTTAAA GAGGCT TCTGAA GGTTAC GCGAGC GTACTA CTGGGT AACCCA GATATG CTCGAA ACGACA AGTATT CCTGCA CATGTT TTCCAA CCATTT GTCGAA CAATGG AATGAC ACCAGT TATGAC ATGATG GACGTG GCACAC CGTTTT GCGCAA GAGCTC AGACTA CAGGCT CAAAGA AGTGAC GATCCC GAACTG CTTGAA AAGCGC ATCGGC AATGTG ATTCGC CAATTT GCAGAA AGAGCA CTGGAA GAGATC GAAACC TTCAAA GCAAGC CAAGCC GATCAA GGTCGA GTATTC CGAATT AACCTT GAAGGC CTCGAT GTGGCG GCAATG CAAGCA GAATGG CATCGT CTAAGC AACGAT CCGGAT GCTCGT TATCAA TTACTG ACCAAA AACTGC TCCAGC ACAGTG GCTAAA GTGTTG AAAGCC GGCGGG GCGGAT AAACTG ATTGGC CATACA TGGCTG CCTAAG TTTGGT GTTTGG ACGCCG ACCGAG CTTTTC AACTTT GGTCAG GCACTG CAGGAA GCTCAG CTGGAA ATTGCC GCGAAG AAGCAA AGTCAT CAAGTC ACTGAT GTCCTT GATGCC TTGTCA GGCAAT GAGAAG CCTAAA GAAAAC GTGGCG ATTGAA AATGAT GGTACG CCACCG CGCGAT AAAGAA TCTCTG AGCCCA TTGACT CGATTC CTCAAT AACGAG TTGTAT GGTGAT AAAGAG GCTCGC CGTAAG ATTGGC GAAATC ACGCAA ACCCTA CTTGAT CACGCG GTGGAA AAAGGT GAATCG CAGAAA ATCACT CTGCAA GGAGAA GCGGGC CGTCTA ACGGGG TATTAC CATCAG GGAACA GCCCCA AGCGAA GGTGAA ACGAGC TCGCCA AGCGGC AAAGTC GTATTG TTCCTG CACGGT TCTGGT TCTTCT GCTGAA GAGCAA GCGAGC GCGATT CGAAAT CACTAC CAGAAG CAAGGT ATCGAT ATGCTC GCAGTC AACCTG CGTGGC TATGGT GAAAGC GACGGT GGACCA AGCGAA AAAGGC TTGTAC CAAGAT GCTCGC ACCATG TTCAAC TACCTA GTGAAT GATAAG GGTATT GACCCA AGCAAC ATCATC ATTCAC GGCTAC TCAATG GGCGGT CCAATT GCCGCA GATTTA GCACGT TATGCC GCGCAA AACGGC CAAGCG GTGTCT GGCTTA TTGCTT GACCGT CCTATG CCAAGC ATGACC AAAGCA ATCACC GCTCAC GAAGTG GCGAAT CCAGCG GGCATT GTGGGG GCTATC GCGAAA GCGGTT AACGGC CAGTTC TCTGTA GAGAAA AATCTC GAAGGT TTGCCA AAAGAG ACATCC ATTCTG CTGTTG ACCGAT AACGAA GGTTTG GGTAAC GAAGGT GAGAAA CTTCGT ACCAAA CTCACT GCCTCT GGTTAC AACGTC ACTGGC GAGCAG ACATTC TATGGT CACGAA GCAAGC AACCGT TTGATG AGTCAA TATGCG GATCAA ATTGTC TCCGGT TTGTCC AGCAGT GCAAGT GTAGAT GAAGAC CTAGAT CAACAA GGGTTG GATACC ACATCA ACCAAG GATCAA GGTATC TCAAAT AAGAAT GATCAT CTGCAA GTGGTG GATAGT AAAGAA GCATTA GCGGAT GGAAAA ATACTC CATAAT CAAAAT GTTAAT AGCTGG GGCCCG ATTACG GTTACA CCAACG ACAGAT GGTGGT GAAACC CGCTTC GACGGT CAAATC ATCGTT CAAATG GAAAAC GACCCG GTAGTA GCAAAA GCGGCA GCCAAT TTAGCA GGTAAA CATGCT GAAAGC AGTGTG GTGGTG CAGCTC GATTCA GACGGC AACTAT CGCGTG GTGTAT GGCGAT CCGTCA AAACTG GATGGA AAGCTA CGTTGG CAGTTG GTGGGG CATGGT CGCGAC CACTCA GAAACT AACAAT ACTCGC TTAAGT GGTTAC AGTGCC GATGAG TTGGCC GTGAAA TTGGCC AAGTTC CAACAG TCGTTT AATCAA GCCGAA AACATC AACAAC AAACCG GATCAC ATCAGT ATTGTT GGTTGT TCTTTG GTGAGT GACGAC AAGCAA AAAGGC TTTGGT CATCAG TTTATT AACGCG ATGGAT GCGAAT GGTCTT CGTGTC GATGTC TCTGTT CGTAGT TCTGAA CTGGCC GTAGAC GAGGCG GGACGT AAGCAT ACCAAG GACGCG AATGGC GATTGG GTTCAA AAGGCA GAAAAC AACAAA GTTTCG CTAAGC TGGGAC GCGCAA GGTGAA GTTGTT GCCAAG GATGAA CGTATT CGCAAT GGTATT GCGGAA GGCGAC ATCGAT CTCTCT CGTATT GGTGTC AACAAT GTCGAT GAACCT GCTCGT GGCGCG ATCGGT GACAAT AATGAC GTGTTT GATGCG CCAGAA AAACGC AAACCA GAAACG GAAGTG ATTGCC AATTCT AGCAGC AGTAAT CAATTC AGCTAC TCAGGT AACATT CAAGTT AACGTG GGCGAA GGGGAG TTTACG GCGGTG AACTGG GGGACA TCGAAT GTGGGC ATTAAA GTCGGT ACTGGT GGCTTT AAATCG CTGGCC TTTGGT GACAAT AACGTT ATGGTT CATATC GGTGAC GGTGAA AGCAAA CACAGT GTTGAT ATCGGT GGCTAT CAAGCA CTGGAA GGTGCG CAAATG TTCCTC GGTAAC CGTAAT GTGAGC TTTAAT TTCGGA CACAGT AATGAT CTGATC CTAATG ATGGAT AAGTCG ATCCCA ACTCCA CCACTC GTCAAT CCATTC GACGGT GCCGCA CGTATT TCTGGT GTGTTG CAAGGT ATTGCT ACGTCT GGAGAG GGAGAA GATTGG CTTGCC GCTCAA GAGCAG CAATGG ACACTG TCTGGC GCGAAG AAGTTC GTCAAA GATATG TCTGGT TTGGAT CAAAGT AGCAGT GTGGAT TACACC ACATTA GTTGAA TTGGAT TCACAA AATGAA CGTGAT AGCCGT GGCCTG AAGCAC GATGCA GAAGCG ACACTG AATAAG CAATAC AATCAG TGGCTA AGCGGT AACGGT AATAGT GGCACG AGTCAG CTCAGC CGCGCT GATAAG CTTCGT CAAGCC AATGAA AAGCTA GCATTT AACTTT GCCGTA GGTGGA CAAGGG GCGGAT ATTCAA GTCACG ACGGGT AACTGG AACTTT ATGTTC GGCGAT AACATT CAGTCG ATTTTG GATACC AACTTA GGTTCA CTGTTT GGTCTC ATGACG CAGCAG TTCACC GCAACG GGACAA GCAAAA ACCACC TTCACT TATACG CCACAA GATTTG CCGCGC CAGCTC AAGAAT AAGCTA CTCGGC CAGTTA GCTGGA GTAGGG GCTGAA ACGACA TTGGCG GATATT TTTGGT GTGGAT TACACC GCGTCA GGTCAA ATTGTT TCGCGT AATGGT CAAGCC GTCGAT GGAGTG GCGATT CTCAAA GAGATG CTGGAA GTCATC GGTGAG TTCAGC GGAGAT CAACTG CAGGCT TTTGTC GACCCA GCTAAG TTACTG GATAGC TTGAAA GCGGGT ATCGAC ATGGGA GCGGAT GGCATC AAGTCT TTTGCT GAAACT CATGGG CTGAAA GAGAAA GCGCCT GAAGAG GAAAAG GACAAT TCTTCG GTTTCT GTTAAT GGTGCG AACGTG AACAGT GCGCAA GGTGCG ACTGTG GCTGAT GGCAAT ACTGAA ACAGCA GAAACA CAAGAT CGTGCC TTTGGC TTTAAC TCGCTT AACCTG CCTAAC TTGTTT GCGACT ATTTTC AGCCAA GATAAG CAGAAG GAAATG AAGTCA CTGGTG GAGAAT CTTAAA CAGAAT CTCACC GCCGAT CTGCTG AATATG AAGGAG AAAACG TTTGAT TTCCTT CGTAAT AGTGGC CATCTC CAAGGA GATGGT GATATC AACATC TCCCTA GGAAAC TACAAC TTCAAC TGGGGT GGTGAT GGTAAA GATCTC GGTGCG TATCTC GGAGAT AACAAC AACTTC TGGGGT GGACGA GGCGAT GATGTG TTCTAC GCAACA GGCAAG TCAAAC ATCTTC ACGGGT GGAGAA GGCAAC GACATG GGCGTT CTGATG GGGCGT GAAAAC ATGATG TTTGGT GGTGAT GGCAAC GACACG GCAGTG GTTGCT GGACGC ATTAAC CATGTC TTCCTT GGTGCT GGTGAC GACCAG TCGTTT GTCTTT GGCGAA GGTGGT GAAATT GATACC GGTTCA GGCCGT GACTAT GTGGTG ACTTCT GGCAAC TTCAAC CGTGTG GATACG GGAGAT GATCAA GACTAC TCCGTT ACGATT GGCAAC AATAAC CAAGTG GAACTC GGAGCA GGTAAT GACTTT GCCAAT ATCTTT GGTAAC TATAAC CGTATC AATGCC GGTGCG GGTAAC GATGTG GTGAAA CTGATG GGTTAC CATGCC GTGCTA AACGGT GGTGAT GGAGAT GATCAC CTGATT GCAACG GCCATC TCTAAG TTCAGC CAGTTC AACGGT GGTGAA GGCCGT GATCTG ATGGTA CTTGGT GGTTAT CAAAAT ACTTTC AAAGGT GGCACG GATGTG GACAGC TTTGTG GTGAGC GGTGAT GTTATC GACAAC CTTGTG GAAGAC ATTCGC AGCGAA GATAAC ATTGTC TTCAAT GGTATC GATTGG CAGAAA CTGTGG TTCGAG CGCAGC GGGTAT GACSTG AAACTG TCGATT TTGCGT GATCCG TCTAAC GACAGT GACCAA TCGAAG TTTGAG CATATT GGTTCG GTGACA TTCAGT GATTAC TTTAAT GGTAAC CGCGCT CAAGTG GTTATC GGAATG AGTGAG AAAGAC CTGTCG GGTGAA CGTGAA TACACC ATGTTA TCGGAT AGTGCG ATTGAC GCTCTG GTTCAA GCGATG AGTGGT TTTGAA CCGCAA GCGGGT GACAAT GGCTTT ATCGAC AGCCTA GAGAGT AAATCT CAAGCT GCGATC AGCATG GCGTGG TCAGAC GTGGTT CACAAA AAAGGA TTGATG GTGTAA  

Inserted

Dec 19, 2007