Target   IDP00348

Stage

in_pdb   : 3TFC, 3NVT

Locus Tag/Selection DB Lookup

lmo1600  

NCBI Protein Lookup

gi: 16803640   accession: NP_465125  

Organism

Listeria monocytogenes EGD-e  

Common Name

bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase  

Gene Name

aroA  

NCBI Gene Lookup

985307  

NCBI Annotation

catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate  

TIGR Main Role/Annotations

Amino acid biosynthesis  

TIGR Sub Role

Aromatic amino acid family  

Comment

 

Selection Phase

Phase 2: March 2008  

Date Approved

Apr 15, 2008  

Justification for Selection

Drug Target Function  

Justification Codes

 

Priority

1  

Sequence Length

361  

(Subtargets)

 

pI

5.22  

Molecular Weight

39.7 kDa  

Sequence

(Check Homologs)

MVNTNLEELR TQVDQLNIDL LELISKRANL VQEIGKIKGT QGSLRFDPLR EREMLNTILA ANEGPFEDST VQKLFKEIFK AGLELQEEDH SKALLVSRKN KKEDTIVTVK GLPIGNGEPV FVFGPCSVES YEQVAAVAES IKAKGLKLIR GGAFKPRTSP YDFQGLGLEG LKILKRVSDE YGLGVISEIV TPADIEVALD YVDVIQIGAR NMQNFELLKA AGRVDKPILL KRGLSATIEE FIGAAEYIMS QGNGKIILCE RGIRTYEKAT RNTLDISAVP ILKKETHLPV MVDVTHSTGR KDLLLPCAKA ALAIEADGVM AEVHPDPAVA LSDSAQQMDI PEFEEFWNAI LASNLVPHKI K  

DNA Sequence

ATGGTT AATACA AATTTA GAGGAA CTTAGA ACACAG GTGGAT CAATTA AATATT GATTTG CTAGAA TTAATT AGCAAA CGTGCT AATTTG GTACAA GAAATT GGCAAA ATTAAA GGAACT CAAGGT TCTCTT CGTTTT GATCCA TTACGT GAAAGA GAAATG CTTAAC ACGATT CTTGCA GCAAAT GAAGGA CCTTTT GAAGAT AGTACG GTTCAA AAATTA TTTAAA GAAATT TTTAAA GCGGGA TTAGAG CTTCAA GAAGAA GATCAC TCTAAA GCATTA CTCGTT TCTAGA AAAAAT AAAAAA GAAGAT ACGATA GTTACA GTAAAA GGCTTG CCAATT GGGAAT GGCGAA CCAGTA TTTGTT TTCGGT CCATGT TCAGTG GAATCT TATGAA CAAGTT GCTGCG GTTGCT GAATCC ATTAAA GCGAAA GGCTTA AAACTT ATTCGT GGTGGC GCATTT AAACCT CGTACT AGCCCA TATGAC TTCCAA GGATTA GGTTTA GAAGGA CTGAAA ATTTTA AAACGT GTATCT GATGAA TACGGT TTAGGT GTTATT AGTGAA ATCGTT ACGCCG GCTGAT ATTGAA GTTGCA CTTGAT TATGTA GATGTT ATTCAA ATTGGC GCAAGA AACATG CAAAAC TTCGAA TTACTA AAAGCA GCTGGC CGTGTG GACAAA CCAATC TTACTA AAACGT GGTTTA TCTGCT ACGATT GAAGAA TTCATT GGTGCT GCTGAA TATATC ATGTCA CAAGGA AATGGC AAAATC ATCTTA TGCGAA CGTGGT ATCCGC ACATAT GAAAAA GCGACA AGAAAT ACACTT GATATT TCTGCC GTTCCA ATTTTG AAAAAA GAAACC CATTTA CCAGTT ATGGTT GACGTG ACGCAT TCTACT GGCCGA AAAGAT TTATTA CTTCCA TGTGCG AAAGCT GCTCTA GCTATC GAAGCA GACGGT GTAATG GCTGAA GTTCAT CCAGAC CCTGCA GTTGCA TTATCG GATTCT GCACAA CAAATG GATATT CCTGAA TTTGAA GAATTC TGGAAT GCAATT TTAGCA AGTAAC TTAGTA CCACAT AAAATA AAGTAA  

Inserted

Apr 23, 2008