Target   IDP90300

Stage

in_pdb   : 4EIV, 3QYQ

Locus Tag/Selection DB Lookup

TGME49_118750  

NCBI Protein Lookup

gi: 211967477   accession: EEB02673  

Organism

Toxoplasma gondii ME49  

Common Name

deoxyribose-phosphate aldolase, putative [Toxoplasma gondii ME49]  

Gene Name

 

NCBI Gene Lookup

 

NCBI Annotation

encoded by transcript TGME49_118750A; GO_function: GO:0016829 - lyase activity  

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

 

Selection Phase

Community Requests  

Date Approved

Apr 21, 2009  

Justification for Selection

The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be specifically expressed in bradyzoite. Since the DeoC domain is divergent from mammalian and most closely related to bacteria, TgPDA can potentially serve as a target for chemotherapy against brain cysts. [PMID: 18950626]  

Justification Codes

 

Priority

8  

Sequence Length

286  

(Subtargets)

 

pI

4.88  

Molecular Weight

30.9 kDa  

Sequence

(Check Homologs)

MATEQIYKQF TSRTLLNFFE VAALTDGETN ESVAAVCKIA AKDPAIVGVS VRPAFVRFIR QELVKSAPEV AGIKVCAAVN FPEGTGTPDT VSLEAVGALK DGADEIECLI DWRRMNENVA DGESRIRLLV SEVKKVVGPK TLKVVLSGGE LQGGDIISRA AVAALEGGAD FLQTSSGLGA THATMFTVHL ISIALREYMV RENERIRVEG INREGAAVRC IGIKIEVGDV HMAETADFLM QMIFENGPRS IVRDKFRVGG GFNLLKELRD CYESWDSVGV SPDTSP  

DNA Sequence

ATGGCG ACAGAG CAAATT TACAAG CAATTC ACGTCT CGTACA CTCCTC AATTTC TTTGAA GTAGCG GCCCTC ACAGAC GGAGAG ACTAAT GAGTCA GTCGCT GCAGTT TGCAAG ATTGCC GCGAAA GATCCA GCGATT GTTGGC GTCTCC GTGAGG CCCGCC TTTGTC AGGTTT ATCAGG CAAGAG TTGGTC AAGTCG GCCCCG GAGGTG GCAGGC ATCAAA GTGTGC GCTGCC GTCAAC TTCCCC GAAGGG ACCGGA ACGCCG GATACT GTTTCG CTGGAG GCTGTT GGAGCG TTGAAA GATGGG GCGGAC GAGATC GAATGC CTCATA GATTGG AGGCGA ATGAAC GAGAAC GTCGCT GATGGA GAGTCT CGTATT CGGCTC CTCGTT AGTGAG GTGAAA AAGGTC GTTGGT CCTAAA ACGCTT AAAGTA GTTCTC AGTGGC GGAGAA CTCCAA GGAGGC GATATT ATCAGC AGGGCA GCCGTG GCTGCA CTTGAA GGTGGC GCGGAC TTCCTC CAAACA TCGTCA GGATTG GGAGCC ACCCAC GCGACT ATGTTT ACAGTT CACTTG ATTTCC ATAGCG CTTCGC GAGTAC ATGGTC CGTGAA AACGAA AGGATC CGCGTC GAGGGC ATCAAT CGCGAA GGCGCC GCCGTG AGGTGC ATAGGA ATCAAG ATTGAG GTTGGG GACGTA CACATG GCGGAA ACAGCC GATTTT CTGATG CAGATG ATTTTC GAGAAT GGGCCG AGGTCT ATCGTT CGAGAT AAATTC CGTGTT GGGGGA GGCTTC AATCTA CTGAAA GAACTG AGAGAC TGCTAC GAGTCA TGGGAC TCCGTA GGAGTG TCTCCA GACACG AGCCCG TGA  

Inserted

Jun 03, 2009