Target   IDP91191

Stage

in_pdb   : 4EJ7, 3R78, 4GKH, 4FEU, 4GKI, 4FEV, 4FEW, 4FEX

Locus Tag/Selection DB Lookup

CAJ77079  

NCBI Protein Lookup

gi: 90265397   accession: CAJ77079  

Organism

Acinetobacter baumannii  

Common Name

Aminoglycoside phosphotransferase [Acinetobacter baumannii]  

Gene Name

aphA1  

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

0  

Selection Phase

Community Requests  

Date Approved

Nov 22, 2010  

Justification for Selection

These targets are similar to actual drug targets and will be used mostly for cocrystallisation with small molecules. The more information we have about the binding sites, the better are the chances to understand how the drug works and what modification can achieve.  

Justification Codes

drug resistance  

Priority

1  

Sequence Length

271  

(Subtargets)

 

pI

5.35  

Molecular Weight

30.9 kDa  

Sequence

(Check Homologs)

MSHIQRETSC SRPRLNSNLD ADLYGYRWAR DNVGQSGATI YRLYGKPNAP ELFLKHGKGS VANDVTDEMV RLNWLTAFMP LPTIKHFIRT PDDAWLLTTA IPGKTAFQVL EEYPDSGENI VDALAVFLRR LHSIPVCNCP FNSDRVFRLA QAQSRMNNGL VDASDFDDER NGWPVEQVWK EMHKLLPFSP DSVVTHGDFS LDNLIFDEGK LIGCIDVGRV GIADRYQDLA ILWNCLGEFS PSLQKRLFQK YGIDNPDMNK LQFHLMLDEF F  

DNA Sequence

ATGAGC CATATT CAACGG GAAACG TCTTGC TCGAGG CCGCGA TTAAAT TCCAAC CTGGAT GCTGAT TTATAT GGGTAT AGATGG GCTCGC GATAAT GTCGGG CAATCA GGTGCG ACAATC TATCGA TTGTAT GGGAAG CCCAAT GCGCCA GAGTTG TTTCTG AAACAT GGCAAA GGTAGC GTTGCC AATGAT GTTACA GATGAG ATGGTC AGACTA AACTGG CTGACG GCATTT ATGCCT CTTCCG ACCATC AAGCAT TTTATC CGTACT CCTGAT GATGCA TGGTTA CTCACC ACTGCG ATCCCC GGGAAA ACAGCA TTCCAG GTATTA GAAGAA TATCCT GATTCA GGTGAA AATATT GTTGAT GCGCTG GCAGTG TTCCTG CGCCGG TTGCAT TCGATT CCTGTT TGTAAT TGTCCT TTTAAC AGCGAT CGCGTA TTTCGT CTCGCT CAGGCG CAATCA CGAATG AATAAC GGTTTG GTTGAT GCTAGT GATTTT GATGAC GAGCGT AATGGC TGGCCT GTTGAA CAAGTC TGGAAA GAAATG CATAAG CTTTTG CCATTC TCACCG GATTCA GTCGTC ACTCAT GGTGAT TTCTCA CTTGAT AACCTT ATTTTT GACGAG GGGAAA TTAATA GGTTGT ATTGAT GTTGGA CGAGTC GGAATC GCAGAC CGATAC CAGGAT CTTGCC ATCCTA TGGAAC TGCCTC GGTGAG TTTTCT CCTTCA TTACAG AAACGG CTTTTT CAAAAA TATGGT ATTGAT AATCCT GATATG AATAAA TTGCAG TTTCAT TTGATG CTCGAT GAGTTT TTCTGA  

Inserted

Nov 22, 2010