Target   IDP91761

Stage

in_pdb   : 4EYS, 4E94

Locus Tag/Selection DB Lookup

SP_0182  

NCBI Protein Lookup

gi: 15900119   accession: NC_003028  

Organism

Streptococcus pneumoniae TIGR4  

Common Name

MccC family protein [Streptococcus pneumoniae TIGR4]  

Gene Name

 

NCBI Gene Lookup

 

NCBI Annotation

 

TIGR Main Role/Annotations

 

TIGR Sub Role

 

Comment

0  

Selection Phase

Community Requests  

Date Approved

May 27, 2011  

Justification for Selection

Streptococcus pneumoniae MccF-like (MccF homolog) - E.coli MccF confers immunity to microcin C and several ASA by cleaving the peptide bond between the C-terminal amino acid residue and phosphoramide adenosine in the antibiotic. Homologs of MccF are widespread in pathogenic bacterial species and we suggest that some of these proteins are involved in resistance to some natural aminoacyl-tRNA-synthetase inhibitors.  

Justification Codes

drug resistance, innate immunity  

Priority

8  

Sequence Length

343  

(Subtargets)

 

pI

0.00  

Molecular Weight

38.8 kDa  

Sequence

(Check Homologs)

MVSTIGIVSL SSGIIGEDFV KHEVDLGIQR LKDLGLNPIF LPHSLKGLDF IKDHPEARAE DLIHAFSDDS IDMILCAIGG DDTYRLLPYL FENDQLQKVI KQKIFLGFSD TTMNHLMLHK LGIKTFYGQS FLADICELDK EMLAYSLHYF KELIETGRIS EIRPSDVWYE ERTDFSPTAL GTPRVSHTNT GFDLLQGSAQ FEGKILGGCL ESLYDIFDNS RYADSTELCQ KYKLFPDLSD WEGKILLLET SEEKPKPEDF KKMLLTLKDT GIFAVINGLL VGKPMDETFH DDYKEALLDI IDSNIPIVYN LNVGHATPRA IVPFGVHAHV DAQEQVILFD YNK  

DNA Sequence

ATGGTT TCTACT ATTGGT ATTGTT AGTTTA TCTAGT GGCATT ATCGGA GAGGAT TTTGTC AAACAC GAAGTG GACTTG GGTATC CAACGT CTCAAG GATCTG GGACTC AATCCC ATCTTT TTGCCC CATTCG TTAAAA GGATTA GACTTT ATCAAG GACCAT CCTGAA GCTCGT GCAGAG GATTTG ATTCAT GCCTTT TCTGAT GATAGC ATCGAC ATGATC CTATGT GCCATC GGTGGA GACGAT ACCTAT CGCTTG CTACCT TATCTT TTTGAA AATGAC CAACTC CAAAAG GTTATC AAGCAA AAAATT TTTCTT GGCTTC TCGGAT ACAACC ATGAAC CACCTC ATGTTG CATAAA TTAGGA ATCAAG ACTTTT TATGGT CAATCC TTTTTA GCAGAC ATTTGT GAATTA GACAAA GAAATG CTAGCC TATAGC CTTCAC TACTTT AAAGAA TTGATT GAGACG GGAAGA ATTTCA GAAATC CGCCCT AGTGAC GTTTGG TATGAG GAACGA ACTGAT TTTAGT CCCACG GCCCTG GGAACA CCTCGT GTCAGT CATACA AATACA GGTTTT GACTTG TTGCAA GGAAGT GCCCAG TTCGAG GGGAAA ATCCTC GGTGGT TGCCTC GAATCC CTCTAC GATATC TTTGAC AACTCT CGATAC GCAGAT AGCACG GAACTC TGCCAA AAATAC AAACTT TTCCCT GACTTG TCAGAC TGGGAA GGGAAA ATCCTC TTGCTC GAAACA AGCGAA GAAAAG CCTAAG CCAGAA GACTTC AAAAAG ATGTTG CTAACT TTAAAG GACACT GGCATA TTCGCG GTCATC AATGGA CTCTTG GTCGGA AAACCT ATGGAT GAAACT TTCCAT GACGAC TATAAA GAGGCA CTATTG GATATC ATTGAC AGCAAT ATCCCG ATTGTC TATAAT CTGAAT GTCGGC CACGCA ACTCCA AGAGCA ATTGTA CCCTTT GGGGTC CATGCT CATGTA GATGCA CAGGAA CAAGTC ATTCTC TTTGAC TATAAC AAATAA  

Inserted

May 27, 2011