<%!3.6-1h/data/swissprot/ 3KZL.pdb3KZLA_ConSurf_DB_pipe.pdb 3E4F.pdb%i[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Ba2930 Mutant (H183G) In Complex With Accoa[/h3] [p]M.M.Klimecka, M.Chruszcz, P.J.Porebski, M.Cymborowski, W.F.Anderson, W.Minor[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3KZL" target="blank"]3KZL[/a] [small](deposited on 08-DEC-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Consurf" --] [a name="5" href="#_"]Consurf[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Homolog superposition" --] [a name="6" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  3E4F.pdb3KZL a_3KZLB13KZLA_ConSurf_DB_pipe.pdb3KZLB1  3E4F3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u 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B`80h*>TDM2D2 siSyK⢣Ewwwp{9l[iAEZ|*nwwwb wu^nwM_vo9c Sktc-҆jaK_pċ`\ FA`)kZZQE( h`KĂ:24n+CEb."4G4h-Hfg~27ƌpo=ٿP o[,W[Z!? ɒWUۿ3Zi6Em HkZٖd`n `1Z9sIlc bMbHjK.\ppl N,\r$Hh' R,XyjM69JMJRI48MJL9{B/{=US뮆{QދnuFZOf{wwwwLw{z-;}®E!/{y8 ) zC0B P ;eٺT*^o9c9M鱉-SŹsª5wvouL\9E ;fnw2ֵD6Eh2mEi9off[oHQBw9 jw}[ZzﮣPNﻺw{ڨT-@P&is/zQ모B6 ˊ wTww?˽nGbgLZQkQhZ -EڷMG?n|{EThU]Ut#JBx "";~HXJZeMEP/@r1 BERشAL<䊕,(&,(&,,*HN8ɓiqŒI44bR bܸ5k[Gi0⅊.D$@LXr2dr$z =$bi )6..|_N{ũ4 2-XUktcb)N4(XHh J*@"HbŌ*DR"H"DX6.XBN44 @@I6-#,t|mdc z9 4Ԃ A$A*yz$I&AII B0MLbFe{"n[32<]M}ߞؒ5D=DeĒEI&O(Q& L-lm6eٙ?z\!Є\)jMM&)bqb$,dB  (HP†( pApR`<`xF(2 ?<1$\^IR ha)D$ ( H2qc!P<  6rYzW1D ÈGwˆV*^ I/iQK$.4i5"ZM5kY]+}&/t ]5;%I binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1 "\\7 <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???C;$=? 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B`80h*>TDM2D2 siSyK⢣Ewwwp{9l[iAEZ|*nwwwb wu^nwM_vo9c Sktc-҆jaK_pċ`\ FA`)kZZQE( h`KĂ:24n+CEb."4G4h-Hfg~27ƌpo=ٿP o[,W[Z!? ɒWUۿ3Zi6Em HkZٖd`n `1Z9sIlc bMbHjK.\ppl N,\r$Hh' R,XyjM69JMJRI48MJL9{B/{=US뮆{QދnuFZOf{wwwwLw{z-;}®E!/{y8 ) zC0B P ;eٺT*^o9c9M鱉-SŹsª5wvouL\9E ;fnw2ֵD6Eh2mEi9off[oHQBw9 jw}[ZzﮣPNﻺw{ڨT-@P&is/zQ모B6 ˊ wTww?˽nGbgLZQkQhZ -EڷMG?n|{EThU]Ut#JBx "";~HXJZeMEP/@r1 BERشAL<䊕,(&,(&,,*HN8ɓiqŒI44bR bܸ5k[Gi0⅊.D$@LXr2dr$z =$bi )6..|_N{ũ4 2-XUktcb)N4(XHh J*@"HbŌ*DR"H"DX6.XBN44 @@I6-#,t|mdc z9 4Ԃ A$A*yz$I&AII B0MLbFe{"n[32<]M}ߞؒ5D=DeĒEI&O(Q& L-lm6eٙ?z\!Є\)jMM&)bqb$,dB  (HP†( pApR`<`xFPXH2EͰm>q&>hQ]Q]]Wu}]_|Ouʬ.L040L8$(.gBeFWB¤Xq 2 >u&)*\8ueQ2@:A'\it,0CǪL8S2!" BAArD2HXt4 8H@-2lj4<ɬT  &2e`SǏ 84m4o.MʜPӋDFL  lDY}iui2UdFQ}輱3bHe^]"idy 8'QBɛM1}G_H{ċ$L&|/>pjx<"  @2! `@ ͛6P* L҇L˶mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+3E4FAfffL?p}++3KZLAfff333?p}1?ia$??@bP@L, ٖA@?rĥ?rĥ?rĥ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1!]PNG  IHDRc IDATxw|Te>gΔtH B'ҥH/"((vŶvݵk[W]W*k]EVE JGtB @zϜs83dR}~̩9s}>mK7Wϯh3~5_f(ǠHH(fSn҃5 8`NIBe$IB  ;Ķ}ߒٟ}rN+3ΫCzwƎ4.d&s}sA""&s_d^bbA_0yuD3~Y1MS1̔Wj%+QWg_#4j_ˌy4/FEyHhƯ8K"pو@/ь_q8pY 2=Sm-CB%+HSX?msFo4q؏D3~Yg0:ʚSz.JBv{'0F4EU=xU7"]l ,#!~?n< %,+W K˖d#i#\7R5/^=[ExU/H'IJhMUQUk^ z|^8cg $jkـ,\.)6cUD$كфndMڽM 핔!cor3 B0>srp{X Y6Y449={i9Gyo]|l*$!!>B eszk=tY3j5ozhżsږC}9? |78SyT՞8t|;z?gg0 Y +3B1PAx k/کTB~`T[NFhvjЄ}+(,X/PF sz_|dt9iSbNc۾m9/ I%Wn3wߐel@Qolձ7BqKԦ_ FU,ulj౭n[kD>oa9zbY}E{V熄$@=쉼jK4;~W<ۤXUXXUt Wx%j/, g*BkU+h"q`5mYآ}*݀$S5/zx5/.!}/F>^#y0#5r_ Udߟ%pبD=q/d]k!KitYS>bA ѪIB1IIbIdaɪ;&f־K_ġ7bT y%D-MHM#Z Ϣ_1i.}.{=nԀn,yeH,!Ǭl<$#j0FʫK9zri$sGq{]MW 9vrODXb=).MZ*O<@׬ ˽{`US1h*J:{x} YhB P#N9DLd)][dDzM_1) -tې%e̼nEAQ 9 WNΝsPU;~(>u݅k[݆YS@pdA]IW2wہb_ѦBN+%npUO /,E!4vXvG㢓г3`̽o3GJ~j4zp!v_>G66;pF%$⢓xT՞0jXQMLdz-}'mj:uMq~)ñui%*/ U$ʣy9d'`">&}G6ueF@-ծǏ7sRY{KȊ!Qawbw"@S@;|(bbBd 1;ȑЏ8ʱ{7nk~@xq`0(DE8)9^ءGAx<{B$!0B+ʹ'#t3_99v0Z4M!_: ˎh0QLXQ#S/@' t o6VlAevALi"܁˻IHmI+Ita)}.A郬 GH4͋l4: ūz] Lq'd;8RzN@ռ$gU3_7Z;Z}a昻#{YcFłx|1}u$Sр*ֽ“'}RN. @U ̐xh Yi} ֨b~оԱOMhHDlƋFOBvфƑ{Uї Z =k>ʺ9tڊa`Eu/_BHXSZ.ir;Yoѽu}}jw IqIp˼_}_Z]S3tTQqȶn!'#n\7QYpzMFQL f,(,(j핼anp˥!tڅ/\\T՜$ !4Nn :P &$)xZރ,$/UlUt( 6*`d`Qө ='f$ Q(&>FoQfoy`9/P][{&uNdJf=J~3y*_Y4>di^2vEfjw4?!8+LTmǡ{eC j/ȲLB\*Or(&6-?( Ub&2"eG0*fG.}pzq-y~{g}{և8.YgChgǁ86.+=5Vh%!K P}={z} =YgHKCZ;7:Vswl а+kb&;w8b"&CMm9 ׳ /Um<&NW]w`Iww?{<E#f{?BFz%-nX k4M^y/qAS)DFisQ5=^|jo gU0`6eGN˵>7#tl pZe=cj$IjT[˸l=|MÝ;ϋHg/ymbP5/錊viDDFC%+g!mYHoѾ:U듑rqW=hƥWql͟郧fg&c.Z[eчjkj5 @5ix.t5r[`Jq.a2Zѣ{S7 &̫?r-[̅IlFdtytL c&gܹ0>)=ܹ7߄s[umN-JAfHӧ7G<ڷIh7l,UЦ4鳾k>hd4l`p(9|\7'܇Q1QrUm]NDG[lݴ!zqt4Ubwr;mtۚ>Lq _ O<˖-c0|տ. nj\]2#K2nWcOʚS.\Gq>̦c(A\n;ͽ.3% ~K%)b"E\\&rN7׼⫪D3{<NbՍlsʻWncV۶59!)Ay 6G5nw[ۢNr=)ݘ7oD(%?٧~Rr/vr)-/bMP9 SaZ߬"~#bbNe߮ek㗎8TCee95U8vy჆}1ȆVxf!4ʫOy:R %#+׭㱄L}A~`\>~'nekZ6D1" 6:(K'“W_͊?н`l*g׼Wn:_49>`g6EbnVyC%Ȉ4MdgĻ?#<#̚5u(&@_57+z}_~"s{s̩7ϥG^) Y 7;9 BOkoс_2iV^HH8>=;u.?PXB#ƫʚS,wÖ E\V|dggsȑL0*d#qtEq=g-۠Fv;蚍s4ёr8ūzu=6TWC\\k> F_7QtkDttJM\Trd`P|Q:;zb7E'vj|msi ˟`3B 2V@Ou9T՛?c0Nv$Mf$MOo8k׮zW/ i-<vg-W-g-v|ʶ2 zefez.$*:$P>1 isq{MSOlp'/  /BuCA\k6a4ZPwy|漊٤C \9!ܘFO39/=)d0{S9rbF򣨚-^0K9y}~GWEȲ$ gTL-G A{1X^3>·Ԥ,d$]^ͦ]u_[MN@qRe=>9jT~!/2<|9|9'O㭷 )*زk6 og۲P"!0-ƴ#6/#F}4f G9͗Qp&]> XQmpNNt1Ffkwx+յe^At1X$L}'TĄ 0TM%::?@n._͘m۷m՝ 79հz5m/̓Gu5[|5^P|\yos)yIN)TѰRuW^̙|NeyTTeun~qoypՆI~ivmft>䣺e% CMAQ FTՃznF4][Ǩ1#(-;΃Wҽ3q荌,ohK089+kNasTSTxOWO?W_}EJb&V[%KWO`~XV2R=Pn.^ ީx{ (ƏZT4.Ph6%/? 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$q^*I%;Ioߕ.kր6 .&׍Ck:ʳHn d!lHZTm>;bPuO$51ɝ؍]фe#%13[@? g-z[Wu7cSqDZbz]x.jX핤/Ote1^E΃܎HK, ?~sS+Z@99!D*CNz_GO6n8 DljMNU~uiq#q{U|04uۗ`1G!e?vE*Y=;I|4eaסYc_Q}$ǧQ1*^8}xUr_moswKȒ!J Y6ڽIV8MhL~+,FR/.:,3Lp鲑'SQo@:^'{o` NR Fm>2rd.OS:SyE%.8Tܴ $=Ps\r}g#\<= =qV[nfj4ѿXjPm=^iݞA&e('7+;4Z:= @-u9͑[$K~߽ vƕ`Zj~cS ̡&i)])-+"8HO&umEVBgCj5asYX8*T]R*XX@^ qRXc⌦>bm]dQ'GH$7ޅjφ5>5gcy/gʹ$m-yk.p8(3 Uiyq<|=.TUϵvLU[s;I ?cm \*56*~o,:؜Ss gC%UƔueQT}m%ȁe438vZ`xmdsq= Ӧ̡.q IR]Knl̍ZxŽ bj*dk\YSA,zݞʟ}mV%{CIH+>w|ѿ_x9If(̭b qcp,(Ƨ:m* &^鶒[<5ڇF#.,Dߦhr Ѥ" n{}Fg|~i)Y83 VA-v<6ɣe{&)&7j.3WI^@kQd%I߳S$uvP4VD>?zm(IanڲmNc>YMPyGQu>sیNvX`ᜬK]jZQDVN >{o̙^fIlLO|W'?w843%PdZd≘ `ɔerRI&q]66QP89E]< s?˻gKΛ%)쥹.3ݑB_)7IP[NĹch:Y]=NB%^ >> n2d<kjd)ZZwC8*?λJ~[oz9_ ]Izٹ2=v8Y \`n$+#/ BA|SA*59E>{< 8pW{N)ePK$sfH8\ӌLtSjS~jŦrxH&c)g<gj(|neEI5ekthg2AHI᚞D2YQi3\z;;g2Hy8}ho_I 3MErLj-Q&JRrS}v se?ʎ棤 )[K`+g;˼P/x7եk;u%.Gl?yϟ񻖟 34TE$aJr{P4˙\U9IO"Kr<凯6vt\ v(~?!")%A ";Hk@"WO 1{tڊf@_++SAH?jK@)ln:V#70>e, r+HWav>K8= )&@TE@Ͼ9tIY^?P(ȭVlOz"۪~ x>$[&Eլ)hC~}z>yϟ[qDPB(c7MICT x\\ ycGTn"Z ;1oں]%<>'o#bAs1n@ܰ/z#Ir>}-4V-kwV#K_v^SDų`^;$#-'N"ڨ[u :9OK +ٲBrYD:Qln:>猈ȟ!.a|[xU{+7ޟsnV|`HR=GJnk\f>cuL31=DIA$~7;/Ag#睊vWbpMkI@O&UBrRÁsx.[BbjF^𪓸6E\6}58zv~K^FGmzN]ܾj/~wg{qm܈4Uk\($ bqL0e#-w-H2c&&g&O O>y: :7l줢D\ogj)jwZS3.A*eXF2Fԣ^BdޑV~7j-f ׮o\WcrpBA4jP=J=lX8-I}#mDU>d2~1=ͯ~uq$A{Ղk}  \'[We9eCEG}?ː@G{oL0($~\X̕YSK[[!~ J x=]ML,x'8\fL4H7ֵ/7_o cPv`؆Z:$P۷]fLQ:H}xn|k-#|C_Pi ފmpqԏᥗȄZ!q  g$V'0[oR]I֘8Dͫ) Au:A/W]y|~7oGɀe%9 Ka4Pz " U%Y_iޠسS0SQӂ <$q4Bl29app=?sSٟŽ4'8r&O=}$Ib=#]1_8}p{d#P_yBd*ņ&wr,`x粚FCTzlY{(7 zEiA=9Gq<}x |3.ς Qxd#!LlbPA@nͱ1+!8'{vc2Y*ufoMqLG#r;iK/E ZQCt+O[p8HN1Ŏw@ۚ#yC>k8<2Jfz>M0>k@ۍJ4:Ż<3Q s$9)}6InrPv/dU}\ >$!cq:3$=~1!Yjr&Ʃ%?;DUmF\YE\8;᡽/u'aB%B.53P9p$E֣1wFC~bL#ܶ͏Pb##|ٳq2&gPxVuw4ޫ,3h<Q_Kq^/[ rVY\Roc gAD%eJN_ QG,ݡlӳw8$B35VWNJy*.ww r*+o؇snCFZRph~fqŎs"FhܜХyjFڔ?";pS A"U72m3$Q^Xms7(DXd QHEpBo% zGpMq[8 ZG 3 pp3\`})'=vv%}%̈́8u,}ȶuGCA6 V9%+FVSX Vi)3Q>YW΁sst]$,(ɯUZKU.v:pyx|N dgQH@ %80:#vW=xsm& _V3$I,=K uż:"B AҢKJeC^i]:EyU\< s eJpya~xחVɻs ۂJ T*ZG($0F06S=qdg"F˭sބ~PJCI~-Dž/8FIYQ҄kc<'܄eKzx}.2Ӻ.]Ú]ʂ:dTDbLG@(QuȞoOg@Bqw܆Ru!ZZWd^r79z-B1K9~Z5W`<_S?8l]l[Oc5IENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZL*"2" UUUUUUUUUUUUUUUUUU_UUWU_ꪪ*??gUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP||ee MWZT5SLT5QSLT1SUTT1Sj *j5L[TSP*jBT534MLEM7j#BSUW_B1j_֡Zi֝juZ_PZTkP֪?EZZi֛ZP֛j _֦?߭Bӭ:kOW_B[ZQ֡ZZ֟i/UZQ֡Z ZB֛j*5Zu֟Z_P_TZU֡LOZj ĄHH3##32""21"# 2$$D"BDd`&f  @HH3##32""21"# 2!"!##30L̈HĈH$W WfWW# HFgL9UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPbinding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ʁ$??ज़@@$@xA@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2#PNG  IHDRc IDATxyt\՝?U},Y`[xbLh$ NB$ar&NNOOOO$ts24atpII1xh+T{*U./p-oK<9 )%DD:F2= R^?e?s̎>VnwT(xt/~_׏eY ,7SuXbA~e{6i)RIBN{9c^`I R8)#I$̕}/S[ 5k^S .q6ēS#y >- Kyx +=3D{S8Gh.=K *  l}@<2ISt^@O]]bYK>[4D2ƞʼ|xJߑ8oa9~]mˉ%&H)ҙuNjO00LՉHN!B> hFtz*wRȪLZM8Qgk?Lxr/"Vs)%'%Hu;9zxwH vG J tr#œ%}IF"9G`[s%>4M#*m䂿xd6?2ɆiǏyY ԣ MhLǣX $H)fZէ%I @J 껄P^)ʩi~ 4DjvZ0=^e$dqt*2KW~7 bIt:ο<%KHiTb\߁CC#Wa[c,DY9Gu 3ywɦ0$'{AOlҙ$ i)3 yG:AhiY s#K8r B`ƜJO t&O\:&G1-])S?۾ag yIMʠ%pl:RZoQ=e />>y=%V'.$es'8OWrm|u7~]34ĄsVGI-$NG >w5w{Q?3KLN2tUCc_*e1-djڞcBs_pN@~_7t0=8>rщaƢ蚇OߗIɤqAKtA"=,Yڐ4[*R (IŜz;/@׽H)IO]ϋ'n_A(؈㣻}%ZYGTVfxr`=3.9N B5(, z:떴L& mg# ViBc?P''g*>F$l Q 9 Ԁՙ&Xt򋙅?Wi:޳w+I۵u\jnUzB_~})P"Ҹ8&)tjR@ih"D֣i{݌A1҆ rOCRrV)S,z6]_G %2~1qh)9 >ܒ(ɱ#UXqg#5eoQkhYW5*QΆy% ]s\"/S%3 (:EgK?'FUx3gstH"pN{"Sf-超Pv!j]^,ib9^MuCDXlڧY'}EUs6ݬ$0M==K $ ӲBus誁T:OXڱj9 =%e#uogE|*绚Hb9G#HkB);,iV]B2=V>#V吨}eUz$}[ֵk}os,)ކafʼntr}NфFU_bJӕ:|+aE漤lH$85>|Q=Te8%mfNDURR7L tfE&;D"Vm]#rфfPqњwbX7+ę]s)NUe]k+Y''95vTEfHjEpOO(H g*KsVjVq. M';ʺ/꾷}U.!4 ѩ\7g$O"9#KǑ>oIO:#rPk/-|}݃drl2R/hcP\T㯔u RLwJ9{ӷd0+Qpeܷ2l,ӹ8*OMqL1^n<95(ē=.i%z]iLFf)< 8Q_8rrpV_ͦ쒷qfV.c 8,W)D*B46BOVavibЉ}Q43\zv%++q[tU!IzV@ U$y^׽ [us⏂8]ԏ0Ӷ|9;OI՜ꂍtè߹B}*i`Y&e[%)=?xV87,;ôZ,7b:R+qUw"GvEfRH$|{ퟁg\OLqύ,nQ ~眮.3>7_uՄƮWQ~zkz,?8k׮e߾}e^0Sw!JRLYe-,KW)kO6UW]5/iѬixNfz;۹'®OdYtvheTP" 񲪭 r2J4M2dŷ+p8̣> ^CYz5~ߏrOzni<_oAD-Zk</LY&#i\g4V@ht_DIҎU|1;,#'*/򕯠igƜk mvSSSDnw]p |֙ٺu+>Xݾ}݈%DJ6jޖuod}۾}7!_Zn3;]"yI3^wW/[ne^kg>SʹuK;Vrprfޙ|(G}t:]Tk{w_w'hӿS駟&Jq=}ak]׳~t]'H044TzlS/YZR~ܫwJoٴiSny@̋8ij>wͳڵ w>O<CCC|>V\Ƀ>{ފm.8EKJ^y7Uyv%~;6qF:;;bҥ466IӤiʕ+kh&IG6Yƍ֥*~ӗݻg$Ѯ]կoڴVZEOO>X;pHrҸyz:L-ۛ{,^{:w]x<:::8vwqo׼x<^{-رd2I$a޽gÆ CUb+ <3tJIWrqFGGiiio|rVZźuX,F}}=uuue Ax&o-Lm@םwsNvܙށ8PT n~e;>o.΍CMhݱqXmؼysIkP G7ܚ+GA_Zq<]N,Kڝ A_RJ<!RxOՒ BOKEOЁ@a,v>3ۓ+l |QhmZbߓR3<:ѴLai;ox},^/Y&GJNWL#] 7Tyulw+Q~t]\|wx~SIMLb鳾/Rou/N8[0T&X3BOn) LL&{YRFξn/h\ηcNX>%a*> ͓8Hg 0 4MWR(%,bUr _n;)z9:rfɱ |'ٵk~eo5+=* yS2NG"y_Uⴕo!/A4+.Ưv=0{/{e?8]wi(q@衅7C)<m3i.9OAWwdlPRGJшZ{=ƕg~B#Hqlo#Z 3GaYƢ: ۶W\N0.`7Un,[ Ƣ!G(;6=5\s/~gV6òΰ }!@2_/y,1yQ9>,i H[0lg9- <3fzc 5Є ?{t#=>GP2y6y'um4;ʨ@龊V a߾}Ud!p-Vmx4e5au-#hkRqږ,c+^ޭR{vzކRR/vnf㲏ê-4dG)5E:lNC[B%'@˃Ct1>Uje_~1["4ZQ&G@qcp)gȪinr4)6cabGxЇ>Ć 뮻Nnc2(TQr5N]ę9a..Jh:@:IJT{]k[&Yx(f5~.>/|䦛nM,$q4[⑰x҇R Ld:RڊsupW`#Ν;-p0 YПٟ}?q DhkZ7Gs+KCs B2FtMĒK͛|{)eZZZ 里!?~y9zHɯ 5N,aۣ!|o\ 7Kr5`?y5; %><+^PX|HYE3;qrpn#&W,Do:lC=4RFK.&atz$ӉJA0/@={o8ӟk1"fGkA)ۓ*|vv +U4eHBJ֞ yYF mOQ}+3&Nǐ~iw Y"ߪ]!b'NwJ5]պBZrᑄƆ8Xeo*^ ΟH6bӓK@dDjN'_AMӱ,T:Z5H<1oaI-hOʢ] " Sz(|QȭX Um=[Fh$RSKA@y*L.؀%- A( W⫥Vlk-BSIJKؓ3 ]1Rxz:Gz3Rho. @׽Lh47ief#4wi%n&I2I/j;oݙr-OP/ϣ #^KkJꗴ~ǚ׸~Gx׀*hih_veZ┚M$f@eQj_6-#uMNU:0Ӽq@C eLщٕ2P[,^G,>B{n %npU "u`ٽo&mgc;-[1Z QB Y-Y75,NM;`h oMhNS-7#{k!NLzvu!SCT#O yHn3FJ%rsFJk5 5Ԑw[ <6yܺs몑۷h 5SqTme5yjNFu_mryj(UV:dF b26E zO<5 K,ٴ8k8wԵ¡F2z gĔK>ܚjU&yj(VB0eUkah^y۶BSCk(5P2j䩡dSCɨQ#O %FJF<5yj(5P2j䩡dSCɨQ#O %FJF<5TSIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLh*"2" UUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ yꪪ||ee PPEFNZEUW_-j5EMQS֡kP_δMSU⦨?/UjPLZW_֢ZuZi]j֫/֡-uQD֡֯jgZ֯/uZBj_PEFNZUjP֡kT_֪j֦uZo U_֡T_֦?B֫PZi֝j֫/j1mjG_S:7֡ZB!"!##30L̈HĈ &fFF fdDDdbDF$@$d!"!##30L̈HĈHHD3220L3""##"1"#!""#"30 @WW Wf#Oꪪbinding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??@@ @?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3RPNG  IHDRc IDATxԝw|ٶUG (*t;6Ƹ%$I8qq[ 66` HTPVfǬVJZ {o~fg93)Oy!x趿Խ˲7/,|}9U_Y/+: YRZ|{潊OUrLrŇ'jnE Y_,fkځkEIw#녙Dw'6}˒]Tǩ*¥:iϸBhඩObSͺȾ_b2cTbVu;hafp92./a|_? vՆA1bP ;);Vџ|ٱL- I/j3sq, іg9%SjkVyӓͺH[jvR/mSB*)-cX!TLo+}Ht:W8lXTUѭݳܢz4dkd]=ӳOsw,8K=jb͢wEx ErORDP@(*ǟөv 0PRQ@yU3Fn= 1.2rNs @d$$]G-Z ؝^@ Mh|^Ԏsf@PCuwD̖*4ME+Ձ$k?ޱ8v;M{`ňf$c˧?ih41Qi*4!~֢4*S$bsgdBFbILƸ:$_9v "{bVkom;;[t\LS^<OL$$:E"#4/B8I˚˾(x[t[$I! .j:o9i34S4/Wy<ܷo'm;!@4TaGdUlzlS <|mݛ;d}p]R /˪AY9E4Mm/;7L.Ws} ( ;kt US.!"+t<E16Z`& ;f=g[? ġ+xS>9vPIr^%n<8E͟&ұs*+̔x^ou1ݩ0;w~Y6p"e'fAר~Ȓo mP FLe^c#]ر Φ5ֵ\ UG6jK>cɻU pn On`.G Y'ͳ{#c0(NU+?**(j`Vtʇ^xU"EoyFHw&4$$욭@q(CIXu.^n܊LщkcNmԦ]D% oA62v& |7.>kN䫯Ny}CO[zs&){nzCW^\ܣw~ᅙcw~WM5f6rUuF%.q1DtDmAy@Lґ?x*~S2|%~kG6PU:hNpa9Uv4in}j:YgINGlT?u+'7U\IBKVS‫NBhX\ 3Y2Pi*a7}!s1[P燝?[t#G.}ք#fC sClt"/W-x Cl.C{ )eTJKmShTx\vKBaj0nm=_ZgǡX7ICV2S[(8]v,N'F'ڑ79U2rNFF]VGiחUم/8,,~ 9J &$q0FuZJβY9I!g`faDdxB͏[b5ݟө~}mj>͠.$dBBoi9I=_—3s_GB@&ɻZ7ұYW=GZZfNLx-{Inf7kgMIXm]%UQUt۝nF88-Bݪ+3']>w ܪy5Qypv%#{7*6#ePϩJ~!Ḣ_?S]nH=XO 2se&s-{0gXlf?-mM֡|ᥥ8MSI6:5ӏqo[N-s9o؁a%kup8a  /_@*L\:ѳۈFdxDa2!ݎ]ә $%[0wC-&v薶7oO^n3Gs'~4Oou{Nz"Iv =cGDieAzD$$چFԎV !0}Y`Pi_jEs[y'o ֿuE]34>q8yɶh'H}NJgX&Lr*Wb `ߢj*G݈g^WKǾ^[ Q#bW&eQ)*-'L{V<§aǡoY! @/x]/6:;'7KW,Du&YVj,VR&W5eO#C%D 7u5_ZA7JQY]џ6up{.h-%c2-gmE-3\4!=WWJ$0 ΐ rlYdIRon߅,@1l2sP#bޭ>kK=PzŎ$] $I"+7B.!0BZW;b`hgSCRTz  جtWj߹VHQi2%y$tčҫac"{M#9m_[1k'&1?ԛ<ˈl&TPa*!:PombP%'S'J()sDhsEQ5DŮiܞcI)4US^웾{˘UqרhBعgsyTFyU1 ~{]EV8pz# Z¹ 3o%yوu`Iy}G#4])ۣ˰n~ c_BPe.lzRURr<<ûaY0[ԡ%٘Uz[\1zBF|gh0]za&AyUOd̀E͢y(!Am)(৤- ǟJڷƮZܱWɓ3v8fGS\. ?6a+i^_֠ƥ_Rf~ơHJÓYL!~#! vX2sec}jCfN= ǮڰK9p"{Ən2}=8aΦEРC7TȊWXMss mhGXEP`kB%jqBcKMrmbz[Kܡ7fuIG!T+v1yͽW| ͮcl( (.ٍ8ռ(֌SM?}N3i{|=V`c,kf-4Ee5I®Z- =Yu7VwCK| JŜp*u7{NyzT;ANE@G&*iHҵbT+bWm>n]m~Kv^*m#6Ə!9;~$d._eQZtˢ/ү(6p!5p W liiIu7JSis92FJ îڽR̜$-UXzœ3ȪFf]ºzK̜$6nc;Y< vF~e2O_{V{pኳcC_0_yһ@p_Cl5;=ovsVWa] vk: Mlv |.@[fV0"-V>^gl[\"+zwu3FG'hϮQU63a@dJVzPw02q>/{LI"vA4,V74ۊgQ^URI΃u͛AfcnCk[6޽v2600ȫ&[I.dӛ9|nDRM꽇٭,4FaT_DyV`Rmb+GT.+Dlt"Q]T0[TBF65̍\f,rV^1λ-\|ө9=)?/#SЄ1/S=.@Ui=A% ߒQr*>F|Wqq獦]9ٱ(( 6:#uڥ0YMة6Wz@7 EQx#N[FbװF@\\fO Phr_jZF'H3ssb=2r󺈋+>taTY8 `߯\-a%Ȓ,PdFҳkyB; -H.-FaT.b~ʉDlUUŏuI=Yi;>GEU)+ٳg{غ%7ٷAh,dĝwA΃B\U]ؖ+ٗ=w:.eY!+7Mr:'/n9IQm$$(3=~ rɓ'  􌔸cd}_:bw sٟ1j57X0a׿p*7BBoWj5iO4ZxwdmR)U{=@Ph rXh$e%NF'buÙNmЃT+1/O* )*Vtũ ?PRϪy {>:u Ns ltY˙4iC0j)))|CtRtAyqxu.^|Ex]u?xڤkz=@]3eBTRg, gф2s(G~>Ǔ d_@}hRA W[NYzu,>)Yq}eb` IDAT9\1 ߀ tߪFOW_3|wKî}ٱ<[zV֭_0jՊ;aqv<>L S uv<͑+-W_}#;;73YYY4 ^!3':7&- VaUms^uFAUu)b$8-3Oሰ.d&Gm޶3o*zN IUW2iBOb.ԯ3GXt)?gkB}4O;&p]6\J+ -/^WR[1-}-%0 3Uڵ+uRIqY262r]N61T[*I".?8hJr>&o#w=/K%IFQ^>ǜBˊɺORJ\Yʄ9׭as<9xxo9}N6l8Eg&՞;|K#bXY;&5u^ÇbB)8y]oy-֠%©sk)2s(cq#F^~ېH63/z)=]ѮuzMOKdoX|U !=YI>Ez)J+ ?B8Q$Km+K̏owIf^iXb0 {<ݮ$N;YAgqa:H+_3|9۹x8}ッsN0bj7sz[º;vlAX&zYCP o7JަsAm1|(n?_XڄF:aX& 6q*u};~$!aZ&\EZ;5H45l 4$a5Up? R.ҩOrwQ^UDQ5 \B.C qټy~V߲= {Wt ""5U?7a,/>[Fzjskƣû!Ww@q6: r;nJ)(NYe!%\+LT]s¥#Aa{uqIV()o|~\x&6ZmfL ֮}#J+ 4h5S/CdvҤIL>CpMt$sڼyӤq~F[l.;;r '" i{h=Ohp8B  61ar ɮ In~ZU6ظkb'GϛovbNV^Ӹp+nhq||<۱􀿤{HEtRf3~$̄mn=bК5̠aܦ+9˾7POv|}jkk5B mC#B`U  :uAUȒ&(ķԾGxc6Y;Qқi}(* N>SM $őXdFByw:W^ }kb7~ ٓ&{^>_|lgܸql6䓖S]O#* o}ѲVƍk`0:jDmȲ® I=T0QQcx1~zJ&b6Dlt"It42/U(O>$'dٴ S.66̚5[ҽwb{И'{w&{e,ݻǨwoϡ=. 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SC'!46+ ^ՍۉWuӗ; |4 &MshmGv 7q>(+*C4_1%w>5,}nST,Q*K+=fa:aPqbw.>o3 U8G^>x%JqCq ~‰147cqz NΙω~W!hA Ӡ2'>a,ӧ8 {LfJ!S2){|>tNK{{>}_4mHJT[_r*k* #?mu7OuZ4'p(.\JqM|>BђUBcy.6&7Yq +2Sryǯ>U Pil"=)G4)΀63dB)jFnJ,+h= K26֣Nݿ~%=n}흃ݷ4Ցi8.-m|vC~8kN`b9l$I0pQYsl]W-'=Jz4 nw/~1YKIgwξϷZz1v#Ͻ5)'*B TO ~U4~c'Gߡ(XrF=011bh/@^#>p:\Ȓ b:T:>]̟~ aHLhDٌbgH-dnZ1Z8]jMiRms=e=UQ:e% 1w:~$t,~,^xG)Zk˥l3\i9@w?AxXCdY]Pivv#$Ȳĥt" oENknȶ]UL[aHp{'^ {g^ް;H /S6?…qδըMWq9ǦQx/[7R0pAU==nv왜%zm6Qy0uLjI`,.7b:U_yXA [k݁t.cIϢl Cs҇B}8xa s ىˉY;DKEYStCco( ,Է+p8GC͇ifȒq/[ݞ={5gCK[=Qq[&GXK^V ʟ`,QFpt~ぞsxg[vv*g.Γ|Wk8y3(lgcғrm7h jgO]i/ЏG0i2 ti*'9z>m*?{3N aM&<t{ڙpW$Bn΅ScU 5<AR\NT+Ni׷dI|.\|>\1OEFla^Z;LLf.0!T'? ǧ|ʔLLnhdOVFmNYIgw+v0OG7u\[4Gdp( Ҧ7. Y\0}Lʞg\ͩw.]?/Mhw4MgDyÚ94I$)nJ(2qJ%=BܽX2o=z|]Nn&&lX$ёq}Wl[Xp1@hRi(\=\#[RTIzrg/e0 UWQLQ w:t>;!=- a ΄d44W),OI21TyQ|_1u:e@O-S:̘ 6xn$NVx2*kR>V(Iv d2%{ ĩ8ٺ{bA4^6p]^3p!/k&qyF$KXjV2>9욯?0KBHDCTDDéIMWQoXS=xn:.PsCHX1|n[s\`k SDǣFxXaH\p\ Å8WI! reL!zgnZ=x|],,^sb!=4cIM#"l/-lƧ䳤n|=z棫QIn)8ˮgPtIIKfWYL|t*Ʉ91 Mdop,ɜ>_Aea2S -U,AZ=T}U$aCHd9yv|Q*kUɤ%e[+<.F=k<~ UQuaP7ï;_ 1vz|PPPPPPPPPP154UIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZL*"2" UUUUUUUꪪU_ꪯUUUUUUUUUUUUUUUgUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT||ee PPEFNZEUW_-jmj LO( UZ/MLEM5 *jB*j*i*i*jPZ5?EGTSP*jTQ_⦯*jb*i ⦟TU7/jPLZj*5Zu֟Z_PZ ]jBUOW3?_j jB1j_Z7TkNU?_֡P֩kP֪?B_Z֟i /j &fFF fdDDdbDF$@$dHHD3220L3""##"1"# @ &fFF fdDDdbDF$@$d"BDB$$FF f`   %W WWfW#gF$Dg/ȌXUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???"$??9? 2@?k?k?k??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 42PNG  IHDRc IDATxyU}%7 ! d%d!a 6.N`8Զq4#NKt;- v Cvܥ.}ߪ/U&~unsު_=y,P D-HR)zRC $bU(J+EueRJC*c%\Ƭ$8N^^ֈz"^C,@՝j|_x?ꏕLwQUQP(vHX{eIdzzUVw%[N8a;Yl' (2ݚ@1kxIs˸hbV ˌ86lL/iLDx2ߕl-dC)E_Ta+췽P;Ӳp=v31yjfDىq"rG)}Cay6ck0p=vә^֘M9IT$/T0 ӰD1O[fˌbL⹽8 ]]v |9d).<W6~U7SUQK4C4+˒TyҾ;abĢ b "9q2^Z%//{FĊAͧr'q+l bEhFII2}zЋ4,*jf>6/+V-BĊG$q pdXRIvzr_nLBp,|l/[^ī<̚ˌIsT`.K%Mu ƺ@x X%+Ο=>WP,8o%u3tp<瀒B+0 BBJGrknI(,|t6ɫ_-aRHwr٪I7 zC~õ$4#rx^Fixn:ign #aM'מa⫩l_F);i2>29sf5MuX10vstB ĠC~=EC BVde~6T$jD(%Jwa;~_i>I abd1 ð4 @(䒥o2^Ir\|}4_ )=\ϡ!@hV]!j.F K_Fe!JA6jjBiD ]dִĢq:Es_/C6|> }F0T']R鮲TT6"2ģD(kӓjVWPDZl /DSvqnQH݇es)J>|44+$4h$2}w`4]6n pJZ ^o;} p`k;Zrv\s+]< uz*$bUgl/9V$ YzQd+ =Oh?0 ԏuORE0`*a;YEjcW)*eƊxM0XQVs-8Ddk4 R(>au(x?LuC2!COA,ZɄ ꪧbCApu'ۊ R"\.RCĿl09x?|?Skc.HapCGr2QR ˜%D1 ,ȟ.e(/ 6J"VX]1՛(ueRtϝbKm. $e0 q]gcf Fe%i@rZ< .dvm'u ~%ؖo۪hG11#:tEJ2Cqb-/ 8YC>_TVV2Baw}<ԄfR^}0L0j4-,3rE%sB<][f!~󼩙s0Uī(9A9I0eq-p5L͜`˪H><8vܶFLFZZZlɄw4*1F9|CG_{3?^^bl2n:`FRĊ%O:7tsnjii4MnVijjx\(_8+F6| 8ӯ?h x ]X%[qe$Iش@t2Q--35"P8 رcGᗟ~6 Q~9^ȝwɌ3x׻5I$TVVYKsD@M4,1Lr؃"~Ovm|#_LxE]E"Q@༕VO4LttqsjD"S`8Z󨮮x=G妛n'˱cǎ);/FuE=h)%3c1Uun~6y;s\9pJ)ra. 'R_y#M3q<)pNm[X ={ڶ=oM²ˈ'f!\3!24|L3…s9x\>C4'N8Ʃ#>Bo|>Guye LtHO4ah" D!t}G>N&$p{YJAZ&~gV| xL4uYp_#KA#<Z0g%hh%uөFUE=+Fp_)ϕ /V:˘0ĺ;P#ofDe:z[6;ƞå7բykqܼ_C&M]tb[|Ɋ@$Vѕ0?kk*|S/}_Io%0Ll7dr)zRe3(pF$UVObw㷏&i1#1 D&I?e|b!cf|[ߢS2ߦ54u[sIg{Izig0Eĩlj~j]pTO;hEV4aDb;ɟ][Dqm1{l~ydjZAnX^ a)\&KwmPO9IMUnd1]Q1 T5Ċưb XÊ`Z*1" %LaP`iy:=gٲeG?Fum;K6$Oa;P)%^Ǩj$Oz.0,{+_s{Fo H34-{:TǨYf f-^?u---,]tJ.._NPvɒzBFqgL}Gv8{Gj/Cݤԯ]#(}L"cu5QTYTUZa6EJ3m۶(.uFg BPZҸ.KJCzdgwSX,W:,y;GɆU:JyP~G`$ogq=;t*0MT~ؠ/_MzM.s|)s 'lGaʕ\cwu EW dzq=u8||K4LTneWe/4(Yn\<h:l'GR_3]cPR!' VR<X((40L۱+.M8PӕSdz\P N+jgq .ov`*\!OͧQsH %JyՒoii_,9r.qhIt5$O~Bkk+sw5tѰ|Lqm<{WDRyPEM\NJ 7aۓd}K!dl؊7l 幽4.$+wqL +ٮkiy~*m5e 1_ill{-Y1 O:up372$Ha(cDs} R8NΗ4M,m_uNЃ1K|;466L&~ƳϖzteDqmJ9PĉFfϵi-[p%+'=|{.y;C:J/)xu7M, R$ K#a76J%1(=J& _BV-@x(_hP{2ܺV.JRq5il&14ޛҼW_Ay Hp<^2\a-˹i0%Rcǎ,\X^])ts KRHEW:"QK&G_mD8ꝯ3Q9s0p?ŀGJbKrsz jLgom/eѱ7[pĢ$u5HxΌ[PG)ޓ \JWNBAVɤ0Y3=&G8ud] $sg-ǃcmG/K5e0yQQqfzs IīQJIs9޶lkt饗rs7{|+vf9^AME=2U| Yh ׼/ۣ3(aXہaU}h+aΡs!`ѿ-g2qÎ{ ay6ygUOK~J#B||::S)lA';qptcegM+"(_ݻw;?>m6غU?> b^IWOmj~K>3E(]=#E+W#:~oML.9fh=ŒTHU*lhY7tЖ-^ [)^ē.]Ƃ8#tOߋ)/=s"V%% tZ޾qKSlRTW6αU*?GmڏH*TWև`3o"o[5;\O}sm&pij@Htn0ށxilsHg{HguAPX3R[Մ̻?ϓ +* ?ݬXwQ DAzx3|ѳolDZ(Rz8nl>Kf{I;Y=3c^hXD# -ve-8ˀ2w}7l܎;رch> Rʜo';*(:GߦL?bXC?F$CJs=t.I:K*v :`JeP(~b4KLPdzj}vr/'駟f׮]W|Qի "%zW-FDv n ωUR'ggPR ;x 6Iŕ.熟W6GNX[,R\ߡ~=nIHv2~NZ{RpWDx챑+l_ӦM 6psu׍{ocUmG P~G]-c蝹-()I|a*=]E*vS/A)n~y1M ӊ%IeIeMuN9q@o)Wsm:6l؀RG>w^~H]5I1f,r*]V:{5Jwd+=v+}O_1-U ogE*ǪhɞWTe~|+u]=`__---<!Q6oތ8l߾:x 6l0h̯~ݻ;S0UF{OI Nڢ:@PGGW~  D)]</ '}ñ̝fjGûbʉk$dܹ,ZyqO]xH3}-8}^4㏳q~}d߾}(ym+]Гۓ_v:lX0g2;diD_*Ås[x'5Wfl߾x<ٹs~r:<V~j&1=Uu}K_bϞ=ٳUhX**8K$(&9f݇ԥٝlo 3zy3jռۘIg{Eao M"X<2f6sՊr`ժUa]гZL;dN`s,_q =U8(( *Lf0L bF|NVAp0`R#CdrIzN۪Mi*ʏoţ Fv섣A~߷o_W9v?яxZ)̀ KU`KH^yH[Yf4{&CY,6|7?C ͍0ImU#Օ T&t.+F&#r}6nnAǀb6---<<lݺZXq& 'sJ݌y.Dm3TKa϶&aXY CR]@"ZI,V ?/_"uuuDQ..y%(@1q||⡇3Ν;g>} nF_.\x;`癡JDG@-@q8F9яeFxǦ[ٴ=]xʼn{KˉPIiu& [bBB[,o!s؋abd#8L6KKT{x[YQ'pq A)x.{ /{? HD0UQpUNv"9M{W HukY*v'r4/ =a̪R匡 CKa`Q I8RJ:O0sKu yY% Q;6UYrےR+JrJ-.ZaaQ̛Wo8rvb<vñt I6| RG7Y{a] a2U}Z-w@?sUJ7%jHvU_}hP!ݒq̥daҡ\Ґ7lXhJuF?2CmWA*0J2oKAR'޺ z1 nac_ߚ}TwFv 0}paIsg. MWC7! yHJjeغ?8;z(PGa$<&qSdը" ԐG9H")@qӵAII<^vԨU8RwPFs\K.m m~?`UQآ|(~&N m@)R+ߤZ|u*cE04AUue9>{"Ƈ-jΣ3r@|iՀ-k.Dǡ![hK9BDEt .̜`\E$PLOjZ{<>ރt~ -83`o(+#L ˈbZ,a~_tҷ aZ>9İO ='̄QJ2q.RJ~/<^SsU"-&#4"XVh`aMA@>R(d?mXn|̥~WAIoB9qZHbt.8o5 fa /Nmme _K<)]\qa?a賿usg-cݲ'PY&vp=Gǿ>^!@Ey +¦/YmM%-Xt]?')?($Q+&:/ p '7sg.-*sK%'q"VeZa^1~#$b1aaTAO~Lq@ $ ZE#.cO^IENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLc*"2" UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU ꪪ||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _[ZQ*jB__δM__M Z/jSo֡Zi֝j֫/֡BZPUSLOjZBZPLZW֡kMӭ:kOW_/c-uPj֦uZojB ZBDB$$FF f` "!"20Ľ3ȈĈHH BDB$$FF f`  fdd`&fDDFF$DbDFBD$DFDf`@W Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???YQ$??@G@)4@?f?f?f??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5T(PNG  IHDRc IDATxy\y[[WnRkG$2؄0qLlglqb?gll$$$ƌ,1m,fjuK/{ϙ?RUVu҂~[{WU9*ŻɦӶbK-m,xz\ƺ%ZB)B)/T(Z</xH$RJ*u3pJ\2Kᴋ"K!xד(O월 6\W9zPHܔK$Ǒg]O~'T{\.| 02GH\uAdڻp,gݣD*u/8&RJTr=RIN_Ȓ5gWZ979ж'q<-$m&G1J*XR̝KSJ0gr h|y\T69:dC hMee*hRZZr ttő:Fnŕ Δ[{؊eg2hǃ3Y@z!P2Фf3+-˜Byɬy]?;W@KVVyBm fTTŪHIU`K ۝Nk]&j]W_Tv+Ys/),L4[Z(Bkd.AG )ߡ-,YUta49e[k,\t=kcMb Qv Z="v e&x) [InXȕ+${̓Tsr:t m&9z|e´R4G)0!_*S` ưi-5rVk9Y6tz*4Mö͒ p۩iƲMVn}0$BhBcXdoyLxrꪺ]:Zg\WƺoknXN]BGJ&[*'rfp :K6X@-n\jdj_/ـ7\Iaif#tŶMЈT&@0u_,Laa}R8Œ΅`l Ns䡒VkQ0G:_-xЁj hBò%8"[74-zaQΝ4gE"̝"#Biݣ9;i=\_ybK LM-_d8jN/хuL`LЕ*t?(2{4] eNmMhضM`'_YQ=N?sW~7n\R [Z[IZJ^ٶ3OwYpɧ WcKxr'^-8 4o<0ǖk0ƤkmOW?mcYiNW&_5Rsn )w/L+UT/z]ӱ4}C]!"X (%*IKSiYt٧Fmdϼb3$u yr׃+$L'Ʈ]pyp~?,h(Ha$1nZ,tMG/pV?*\i}C]<K6\^B볱B|_?yOfV\KO<#myq}]Pz!Jc01ynb;p5"e<^Tl:2@`+i0I˚eL{Ncc#g޽DQ~sDɃ4< 'O䦛nyޮ|})1j҅k8VQGy>r#$qR=gcՒĪPnheLbIL;m<{}vjjj8x vzj~p-έC=7qsshb]蚁Qyn3DB14 %s(/u3P%IAmrI;D"OUT:N25p=y3EbMf4MG!ISvLqg;蘆~yuSOq饗{エcϕNW(jxAj@h:WM ; HFIF좫0.Ja[i,4y[b8wg?c˖-zXP(a9rga24MGJI`X0ȹE_;2 hy-X9sP֫څXVxb}wåRi:RFM+0MēCnă)>O}M3mL9/~`*RJz<,4>nϝS , R^h,kct<M n4y74OOcK6Q(Yj>Cmu e&gHN l,tjZ 8ku~m |!Ė[Pqk&@8#mVNcq N;E F(TU߭H$l 6Q8=f 6ڈi&I[I<,60cV^!$n<&4"ϡi !ƴӠ5q<v䝚Bh{Kv lC$SV@ Ė3Xhx]4~ks_@)3hb$m& ĠG 05b4>膟Zw*-;ʩ3i:@a9E4H"5LL \!yB4t(i͜#eH2z`S"D9IcqF$ӣ@DЄiQXX̜m*3AcRtW 1!u+}Ĝ<z;I 2'N`).|sԧ>'?Y%wD @[Ϝ&3 e؍eΝTdR!Ӕ9OpB7C2.S1?x|^{5v}-12Uyف 'HqOEk{v=qwAU;(Hz /w] &BJC74]>MwBi!8 ۷o'j]ID#uCQF((t&B1O4{ؾ}{Q?EE_~eJ_x )3my虬kN<|c*?Pg|kISJL={g>rg{(xzȹf#[c }dQo~}/G{n?|oNkk+H)IRp#G Wɨ(ؒշv0A#L $(?%+_ MMM|uc۶[ 4@ s[f e[xmslS,j\EMP ~{鼏-:ywM(хb!.F@ C&[ s㍕1$NN; ]׹꫹{^Hsv̰ekDKj F)m^-괵y6F{sZ #D0& Ljk  hraz<]/a*aB>=LfWܰi>BhYjM|le#dG#ChXUUTW 0~`>r뭷}o$8묳>s ` ̉6,<ͧG R}lQȳu3RI\%Gh]jF@ VQ]UOMX#P` B(Fh:H'Ž;3/"ܞΗC<ߞ9f7r7wt@0[8$qRKe VUdjC/}쬧UK6:^g9!JNv+s,H`'5DPk$ZUG(.{/0]` pWP09fdǎ| wݺ Rd)m$|1+lभKZjFGz:NmX5U9qߔUh: qCKm<#l޲bse|pzf'Y{֊iC{Wq\Q^I_} !G;\r ;By4dB0ow\1j ;\E<H7#'K6DXp HZJ^?y&w] |`j߉{ zY>3feZl{r{i4wW?l)kű6|UI~ cXC8P]kayʕ!ʦKŢƕnmG 4n^ugk:{8EP !B'-?Mz^^PRkmw ?h"0B1%yZ3-.x=7o E~):SIB+MJ&\ ʤy֯~ AtM+~BcokG :R:NQ42.h\s t./dm޴sA}͢Mf;jذf+pF-KIGoB,n\5fv'i ֌Ɩ;4sW'Zɟ 練@{sqIY{R(%⌕K -0)n.4Rcv %  |!,=<8B4CF{s^Xロe˖pBD"$I6mĊ+!Df;xE;tW"O]Bh݄e假'9 {QBOUh[>{+,Me"Ns DA i>z{{IRM]y啴zj4Mn!L6 >ԡWZj]xJ?^ذ=;Tɣ7NIc[6ïzؼn`7I mtgBGs*Z`A =T(w;0|os]{\q}\vec ȼqnjIqRYha2+,rGLc&?x$/D^ؼ _ˈcT#yQtL;MWO~hftHdф7DNޙ r _|1h,l\LiKB7myڧi jrEfL+Cmﻙt:iuFcy8gs`|x@)E[3ci R6(neT 0hdz8_8XB~M6bʕ,Z&b300K.KOQgōPS  7_iL'ϯX{敠2HrF(m=){l[ D0 %YF3l'%IIjhiiaÆ heͧYhqj'YdkRJqC j[2g^e3Jd̲I}(%9r臱J4)W)Wd/{^/TfZ)FJ!5 p5PS?(˶Єcɖ;kd0{6&&<ϻ`Ik(|5sYwp2)F9q>p(` ["39g\ɾ7C>Sx&#R34XCN$Ydɐf41Xxcǽ&9h_Ac=^7v_2< VnxZYpLҫ'+>}i%z,F]OdF(ƹ5 Ŷm۸KҗfCNB8pBhNI_ow,ژa ie(%ydQo#GMw*Bi3@CJ{򐌓oLy6 s֚\ZuVlJT蚁eXVaդC=),k|48R pv#=|KݕhPCIDAT4sˁ5+V#G*#\ˤJ8ۀT:SPucRVsƬw_bRڴ4}?,{+)oQ__?/!N7JSFB HgζQfYF(fVx9mrP'Bp=P[[WZ!J`b,s>6tB},+i˷'w=8ӡJ O,3kk8kE(%K oei.9[q/P {M"6yggP矔kqc̠a)Q[&U7}J .ryfGf'cV"bFQ5s>DU(gΎD1!"jtMt#ꫛ϶wlS2(y7:nx!BnPh-'L̞<lE׃?}e-ܩIS( !P=?I!Q$qy.t Z%t*TnvhzV]HG^؉}6bX|!RWe aӏRi{3O=%IOntg@?M˔(LQ_dd੎/k:$ӣ p ]s(Em C7rޮ~,bM1mMUFi->G/k9dz,Z",ϾzFlH!<1LUp)1ԤCW(z{LKUP^rGBiw<>gM6ɳqds5-C[1'"ea/ygOW^BH'Wua}[\{SQ%TW욋0 4.r-E2WV|vb~S^1>bVr`Ҽ{%7mMAy?#=J,r9j dzΓ)O>GRJT4|w$+n +Z-!d)WYܸ_ex Ěǹ#2ZV9kA;A30ywCx:i뼜TweIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZL_*"2" ꪪUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUE UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ⦡1ST_δM5֡7/jPLZj*5Zu֟Z_PZ ]jBUOW3?_j jB1j_Z7TkNU?_֡P֩kP֪?B_Z֟i /j &fFF fdDDdbDF$@$dHHD3220L3""##"1"# @ &fFF fdDDdbDF$@$d"BDB$$FF f`   WWf#'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUbinding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???}PH}$??H-4@@?w?w?w??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6EPNG  IHDRc IDATxy|3g?nPD\@uPҊVUԟZZ޺"nubDesl$' 5ɜY33g>GJM$@@kM:f_4#K\2S{ڛoIS@ |s+wZ8%HP (Acq BO}fF<`0@P lyԞ ߕni "r6 +񊇵狱֟1{@ >D@=>7 ;@[{k[uCӧzJ'=ޣ["$cňh&q5,\xֵ( PP`h[QZ( Aͯh/{77zh>͉jN˺/B-% ӗ ]/@,/2R{ҋdw:6|>>uGI`Я!+'{Gԙ|(hR(B/_2m5*)lQF4@O 'P݄P5Mu<ģ>}0w@ng*Hf`} ~h=Gqik"QBFތ} 蛝 v|9fA?߰Ѧ̘8ŁH!xwBz]"PBwn7MqgPSw8b;뽛CvFE[!=wvr1avCU{Ivv'r$㰻)]=.Ua偠?m~ӮDfZ(+ >mşuZ.8Z6vŦ) +.G .g v',j{Ks.Z&­( E '{0ϬMݴ+BBb`SZigp|rw}fEY`D6܃̴>d%ɕۙJM3ˈakTɣ AMm *^_U8PkJi)جjdPd"i:jەʑC$IF$\$ʟAᶷ[K}CzO* x[vOfZo\mwI|4=8.>$૧ґ+C #,q,X]DNGu#(Bb"!3~|a#$4(N3 ͣ{KrA}dhW:?w@5$ҩT?+=iy[|A}$%b"[V,VgQ^U۩8I05\ po%_(P#fR㘪-щD^9HDcTj٤˞bDdjoSUs$Wu$$,ySټcCsWϞ5Nд:yg$"ڛm.676Uh)ťElS9ZI YkXpJoe1]-iC!I2A%`kGjc mMzJ6iX-d l"[ټ#Zpe~V; aڱVƎfԬYoھwON2!P;\EhGZ͉nu`ٱfqi*_{ke]۾_J`Wg;$Cns6'vťEUںJ=5\?֖ޠ;q3fA$:D;ݷJj BDOE!%)?7z|G1'匁F`Ԭ4N]ϲѫGJ9ZeۀZdyC7[Ihzи?ϥвY 2Ͽ~Of9 (,nlwS<C$ a"-/cqpړYX-6dYV[e/ kKNԬ.cZKqi$c -9\p*H?C,"eʹB.슲8S'nW*V*ېdY5Z{ 3B$Yq`SHZ"_9lcXѿ|jRfZ<=3"L2 RX6E?Hv;~V M.RlX`|j9-3ܕe9#7Yi}#%5FG#?5>)Z%bo+ק$%)|!LSsں'JS>HKb%I`-DX IR{ц3>ي(9C3f>Iu87 +G9oIoE IjRi=H$+Jqgho06B(HZ%c~8Yd+!c &6emKDEQ 7`Mۚ4ÁM-W/"[Z%ٖoCժރ;{AnsElm.ťEAKDy#(%Q=vY4k:jp{Y|)H@ #r\FsGQfehQ1a?sؕfm$Ih'=?~y%ZX>k[xf7JгIg$bAyg!pڝx16zQUB;'ǯ/ֽ D-$= Ӭ;yQHK ϝVX6j@8uYQ*C >/}غ0l{w,BvQrBEIЖg`5zՑlE$YܮTғ  CvO@CdeWYOD #e[$N<3&nsi=vl`Ѻ$T 鵷ЧG؈YA"3!? ||';&k.^!}#͐#$)"^#/W}jdK G$TkZa"Ȳ);^!ĜgwRlt׈hkJ#IH`?\u18X=e%FY(<"F]"j][-ȖkMPΕY p"JXE R\Z?7‡/GI;wFMVt ]gdzv !GKE ruvښAc !) Sz˗ &6΅m}˫J8/dy Psې +&A Т,qvvI j$d"Y(NQ\Z{_ WJѬcC>`\H2!uٖd#(h2 dg i[v%jǢ >_)"cC=jN*;xnE8848I8nV6҅h2mqizuiXY΋9h o`]2#uA&"ipI8nZ0L *~.8k.?,26MB8k{W?x"du*bw6scذY8l6v ɖZ/! $Tߕn|$P&5*AtJ$"27>^F_]SENӴc-ĈŎhQ ۯH G 1O=J0u\zX,nYށFެ9߸rNWUudǛ6/E{ǵ2NYc|e}HOEzJ/u$daG&A++B:FuTkN,w@(BC0^O}hO"$NyXr%K,i>K,aʕ'1wPH~~>ݻw7v18nQpFW7J_Us~ x?d9(Fl yټy39tFrMqUriT8R\ZKd9yQI~RNjo= 2Oٷovuֱդ6<,^tz_ ̦;G9|5rzZ7Nt +#[l1sݔ{n֭Sg;XwݬN~yzGٵ9}&B݆ވx!GF,^'zP t{܋/3>ꪫ뮻Nlܸ1'|~dwH-2Rz"=,\pNOG\eurT=?}KAhn!/u= ;wSN9' ++ؗJnu>Ƴgt6O{2aGqqQҸK_Y7B? $5O{qe1yg(((?K]]GYIJJ駟6IraFsZ!t,7x#%Ҹ =L+hW4(_K ؠ$nG2:aBiӦj* stHaq<U0WVkXhEEE|'= o OQ' >;%K 2o&;wvt"gVNDPh?as7y' 1u˙eM1elڴ:F{ 1I̋.~UHPhT +S^)SPQQѥzLpS~6Vc'A$9(-M42v8~DK 8Kz]EAujrޱmĉٿt|Gx6:: 6k8QE{߿˵r$x6lѣ1(lPx0"3o{ϝ;wل/lݺGk  !7-%233ٹs' ?zeߡ:;Ǥ9".r5ǜ-Ex?[laխMn`% zR4ŋ裏:~U5c#t 0ʘ/e˖qa>mƩ|$3UHDFNp\v-f{g:zN&C@̈́ hhh`ƍ1(Hng[AW-M|^XXȘ1csD(PTe͆3H?Gj'OL]]_~ʼnW.Tr谶TEd ͰIhO$@l2j˴1$C̫yGYY*[YNh~0/%U1rpRNÐ~D7fBv/,?xvоπ#ePB槨nI[y[8M!W/uM5X$Z=c8y#l\4[{a;iyqrbDW{q,cXtKғGcرlxD meN@a9ۙ0zI䥰DChڱ ЄcQ.jh})%]WW_}0o*2229s&g}v|S]]MYY_z),^iao&8pl| `ZZߕiP{3Z@.,Z5]HD0lAΒ1#Gv`+W2c  [%͛GYY|M9&N~zٺu+~a+Riq s;C;1ܗAQM]%iٚ.ks5Hj,P U ,\7U[0@oܹ=`M1̙35jeeevTs^ r4~5N˗/')) iYCuíKA&* ѷp|6Y W u{ܧ `׮] <Iૃ[+VP__#×E5}܈[y}&|vf;[nwuW?[:=1/}kքZAi b~+6vspf,XlnCc-/aiTW]2齴4c;tZi0/ ky*++;; &͠^`.M/ gy.]ʆ x;;)&͠ j y'N(^~NOw;CL:ϞzNO4tj#… kR$)a۶m:g6pOMI={iph<>Ig}[&MUMxLIܘ1S<&qc$nLč)1c7xLIܘ1S<&qc$nLč)1c7xLIܘ1S<&qc$nLč)1c7xLIܘ1S<&qc$nLč)1c7xLIܘ1S<&qc$nLč)1c7xLIKCIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLe*"2" UU_UUUUWꪪ* ꪪ||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i o_/ML֡UZ~ TkNU?_֡ mjGZj֯jgZPUjGZjc/j Zo֝i֫ZjB֡S֡kTZW3?Wj_/"!"20Ľ3ȈĈHH fdd`&fDDFF$DbDF@@"!"20Ľ3ȈĈHH DHH3##32""21"# 2!""2 3WfW#?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???&$??׃4?,K??`a?`a?`a??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7XPNG  IHDRc IDATxwxUd˽ǽ:͉Ӝ{OHHB]ڲ ,,'PB $^'۱n3#ɒ-8}]љ9gG<)#27t=.~a&Wo9`>!Qul{/A%UjT dCml6$ɊM!I6d@A}עȺq^sL",^feo :bB" K Ȳ,KXf,6 HbLo$$+6jo+r'lC%Gb5b4j{: ڊO9FCRL|0tsj+P\O28"ʫn ,H /6نLRL_7[+b3OA:A@DO\| IlLe9/7c2)cU 2 {Oaզ\1/ OT֖ *DQZA%KJ7~u0M 3/s";P>Aed$2ˍ/]/ Op@% "*ȲLhP4p2wWug 39}6v Tbt!22.5"}._lxShN쯆lFR+dEǪ_?MSƁInt*vȊ„,ˌ07y sdeG$I i8s9t2&_r;j8gomۥ; 0zBV]~VZ}۱H$/#.6KX,[VTv.@/>Ij|:3ob1o؁oW -VW _:M߮s-4j67̭DGiE>,Q{=Kh"{N_TVۃb$ƍ ;o?fj)7A#7Bx@Yt:g0t|tC5No7N} Z/?^~L Ռf_+ng|[Bv7krztz$"!$djb2c0֡3TîrPmOw_=:$h|XM:'0 @h*gYߐ{񨳽ѤWvil;K?ϟl~sf<3y9}aUy捿~%ǃ(̲ * J={FEuӫ>{rDQ@Ek=6%C%l6 6Ɋf&Ye ٍ*ApdYfWjo`ʛ\ 8i.s& /}"3{݈biˆw22\iqht K".;Ee٬\e{"eKBz2JҒn.%.;òYOg{ԀDt*Y(*|}v-sC}A;gHG`Y,X];D@8prU*_rkdބ6Ky?mb"Rq׮#pG<,KȒsۉHQTHA)jtҷh#~OVJp碿SUSƑӛgjFg@ωD'~{D%ӗ}׶xޤa7:l57T#*DAew f:׼su('f`I _m "#!kw @\dA`hR &=SG(3+jc{+TՔzLVE@#:_mV#g6зhRbzۛΓ& эg6y hQ5\*@^IDQD%QjQDT_>oZ/? KY헷F'@A|/3}a)Mz F=: F5u =Qʻ]*5~p,STveg#u;B &24ILs. \la}'%*?YI6Բ֯uw<0k\*(:ኒ.K$+jj̾H9ι,_-YhqLWO/b$wj&J͆]MCMڊyj5s4{;Y[2@0u:o}ِ4 d1 KUm)!QHDhhh3ݹK`&-u dԡU=qg`Wq0N2"0,ey20,N+L#(lޤc?eKm;#n]Tlv;V{9vbrZ4ViW?d)5T^c=<huA`;˕ecl\Js+#$0:;mj=DW6ơSZ{"<DzxcY8w̓HKɤi} nAj4퇔)}x쉂Mu<}7yvW|ȰDdeS^V6eZ}e,l۷duyg:]OvFQ9R '?9'S)vlWe@$$Ybgט,̀LqU|27~,݆\($], &Gοi3̞9[گȹFiE>F勷J JVu!9 {b$ ۟"BA~Fa(PdWDAjqQ{cbeI㈒758m>,)iŽbK%dMBZp`ef=Fg{w{>ڦ薐(HK-{o{y{08mpF/'^j-*AX-Xmf,V3~$Eg̕]B)l`08ӱ<^əXFgZNmHhp*GMxd &Ju\TZ/?Rb70:c;}Ig#5>ީ#$ՇFRѨh1tUG`B+Ā٬͊,Ku;,c1[|'?6F^QCз(YrqJDv^wD~)~q`rwy|TOMqDkؓo%)y`X&LfI"4! (0;v@ڙxGٷ9K=PZ~Iaj\U؋\d{ 3e#o"5>Cl1`4c4v?A8bUUPZ#g֘Es8֮MCTNHzʋǾw]x-sj 6)]Jrs9XvA?~R6 8+ *ؓՈj&+BS}%tPXpډ0uDT\0z0Ijblٿ­]r\?5>u7SET?=b` _ Yjކb@,+mJARF0J꺳hu“ѨHXjO 4hxi>Rfsi@可w Vv[~O#1[Mztɉ 0yOyzC-y%'8~}YEc~Ŧ~OԅV=!UX&$I S4xx{үhfl1; [p]\z摆y#Ƞ]͚5O>Q,7SϦw~{M"?AZ}%N5Atx j7Mn3{HS9; ż߯s}ltdY&(Z$+ff?X7T=>?aZiϡ|yҸqztBBBIIIpoh|eì +R@j*8Q~ ~> ؤƑ O~:JCVvS`.}5 ZܼEe9͹Hp"$0K:bڈ[(,DoCEC7rF63C؛;蘧^a*X8"I!j@!> &Mbǎlٲ@M "݈$0[Mܻ+rEAeYRy 洓8o)m_|HsjȽx/~,a\7͞ bW F, :Xe=| _i9QyX~;^z %I^X{Wڹl?^D# hq7`7xYfOZG J*Wp֮  (cN5Z^xp S\ɓod݆4 6 C̜ #7(4o4o?su?Za5ƍ[!"4K/oSb<ݽ;-.7b&tRIд~sxsA^1!掹]}GÜF?e :y),}DsOısۑekw7Q#@:I߿?Æ c,[ K?GnؠIJ]r'OVv}e{d^Eطoo?8.TL: :4j/6]G%K,ېe;=.c3gNEwjX|k]~4u''P Hss,FvEdl ћX(6 < Y1P4aرȰD믿AX:RTpjaZ8 ;6΃cK/ 0&a!'k2Ϊi( 3@'mL&,8>18SN[п8DQtr9U^J/`),YFʚ'ccu*QZ(8;v(ڽ?NPk)]{ @@ohL-#,8a޽X&lBVVیn 35ڴi!AQ-qW;x*Spn" ņZFe[|Jb@FBM,9ǎhd̙_vo`ׅ< |};3FNrr2~)׿/q\El ;#PhWXfgbzz:o&w5O>jj򄊲 TbkjvY.hH>{foQTD䎅7TsvjXmֆG%*YH6ؙbb1bYuK6 ia IDATun;ADnۆss]w5֬ut֬3$]wggsHuh9 e> #;;۩XVϔ55d]@,(io<،&O ۶5tMbP3DQŧe߉{ fG$FTX=΀UZgS[Tc目a{̟$ۨȩ⭷Tt8.ݐ[s,R~I͘;LOxINK+W6(ڮ(+ /¼l~'淪AM ~ƎC!/ y饗xG`Jvm;'2|+%4(<aj}j- ZTxB)YY-$ ;Ũ YX CC *P^>,~>Axk|xe; X^dddrJr]W8ƌ醯/lFt|U:t[<+e|rg:W޽Ç`^y$ NGGtŇ>ec}T4yX,Yʕ+k%bZ Jm#7xI3MFNU~~6d6PPwn"D,% $1ؒ5a 掻AXMUj.dʿ,dMb#Sy50 7p.^׋->Xin@mJp~/wcyNMyYhF:\Na<|?"$IbW|DAL~j{b^sk"%#6>]G6|^BSxYz=!>=$N<$s|s*l#4()Y< <{ӧfI3rpͻ]Y}Pb}]ro_n%V7YV猻QB%>qMd@q220&scӦS<>1lAT8ܜ2"( IXf0]\C}ͳ{5ETDs[Nwbh"8O=6y&u ;ooiC^>#Q4mʠ~>rtxzIÖy<~IC<]12 /_Ƨ &> '+0c;7)ɄoӸ&=~7R8 L)dHB? 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"^9˾yc6& huPwR)K3?1=H^F#*ŃpN__VgQ/݉ x}ε~Ěڻ)+glaϨ=[3vNlAԕolݫZ|A9&X^vt59׉;P-<Ȋ܌RjiYXyn*Ȝzh%(PWX޳.ʋV=pM,Td5p&ЉӃxNM+Y ̪ ''d"IY>>wTs ԖQP>]|)Wm%BnWe=8\VmO%/7PPf 3@$n6Fv#^NAob|jK\|EfcʇJ+bxQF_{-Ϣ( uEXY*mHM b`:Y)E? s!=ZP3LG10H&$?\ލ84{e1cV=DvVrmi$=~y^>c~ح8v҂eJGo3ly.sQY[gq?%ƻT@'CE>Xm>)aZ;OQV*Hd~ςcb){N(TaVjްjMuzADi(D~(0TŶSZ$J ngخd6@7i#=9 0)yԔ / ]]3m%5)Kܵ,ctN_=Q̉T81-<^WL"=9$K%kh,-E9%353Tevt4x}n,$>aEU#fS"ڏǤ1iBԕo@Qddŏ塞`9ٕ4*(tIIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZL*"2" UUWUWUWUUUUUUUWUUUUUUUUUW'0ꪪ||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i ]i֡PM5 *jSo֡5EMEDT4MTT4LTEU5QSLTO_BMS⦊1SUj*jb"BTUjGZjc/j Zo֝i֫ZjB֡S֡kTZW3?Wj_/"!"20Ľ3ȈĈHH fdd`&fDDFF$DbDF@@"!"20Ľ3ȈĈHH DHH3##32""21"# 2!""2 3$W WWfW#<"1"#? DgD<binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???`X$??@ $f7@ '@?;?;?;??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8M(PNG  IHDRc IDATxyս?{zgf@YԈD ƅhSLro|bU)$@]ȓd ʞΓL͖$)ɓDH) E(DXÞnh"-@^5Q;`S(]u! êawuYu)oE~X%vyEP!lѡ;x袧]Q}beۺJ V nǶEJimi) L== iPΦt8zL&\M{'8qu)2aNJ RRU/@1]!i-;RN$ݶ~M<)A$hAwK{$T<4{F)yz^Z]H4#e迶"l6Hs3)'AJN|6'E(23r{ɘ~S2cXT2l[q?\ iϲ-CJ42:1ӔeE]өgRX:Zn@bL{z=quב8p{ l^Ӽʇ'QTAU>W q 3g^#@#D? K]]!e1,흍OZ>?t1TUtϋ@3_=|!ՙ {zbρw{xsTXH%xŎ褡Xs[Hrammw]eeeZjP>46þOe|<-4հ8ۘ9e7*}μI5ҴaWl:\z[@g`aUs*++)ͻHk{݉ BN' iii433r͎VUsN>?<oā$ͪ7w p].%I[G3 (*0~sZgc{Ç{-z'?IdJyD' klJjDZV~Z_Na>۝;wկ~5ltttpQ@yZ;zW~hNw4 `}I}Iz+m+ r˼ǯXBX׺\9a\23#Wff&gyf={5kmsOX_#awJyDfie>0$N+_fJWz8+ٳgkwٓ(nw~.o;>c6y֭[GooC1^/2L[jd#; }< .K/ ~֮]KGG~0u*++l444tɹ= aSNQ;c&7%c,ছn3j @ϳlFXLF`rWhG8͂8v뭷osȑ'|[tR_V楧0jys)% ]gJǟg,??яﰧ檯,/baR'iXl6W_}um)((`l6N?t^z%mf4׉lWy94 }u7 D„H}q믧mPNVgfҥ<CΪUB|ୁ֭[Gnn.+WF |;g?ٙeGѕ5ƮH!8Pp$H8; GDP7XЛ1c>ࠎݿY!K,!77,B5 ] iPL3CƢEؼyYk_X<]kTRT=tHRX@U螒 BA}9u~'7`m}]w݅OS̀tC w;K/ 6`Gy0c 1JJEumSNZ7#E(džD[O>363恚v;`-x$#~K?H6Ћ՝8555v-[e t厅0B'PTtS@KϹUUjC6"!ET$˕o0n9,s%pOzв O9w}hGC% 7oIynCDF7Ӎ(iBU##]f*%I{7 ƻf4_v=jJ=Z;2Yf\^In`f.Գ GBd4ZE"U}uXL0F^f uuu455cGb#43 j5r4?>_җX|9k]u3GY~vq/GsZr?K7L,\?xD0jy+=Y9gp/ NAՃ6Ñ5id QBH2?fS/J =M0[ȴٸ馛XIջȰmka$Mz(գ_IxD"t:G T|{ߣl10dDCkaB6*"͑N(b'P\ 5͑h |]y7vx1iҤ3"Λ կ(v}IlK#2žKO5JHX'j7xi'իWSYY9*)W_u {ըh0wf[=/]uU#NЌFN_' }z7KF3`uu%)|T8߽A]t̋CTmOZtgfV\r f"+~"z!\.ٳ#Gc/9k2lRڗ@ّR'AYJ8goxQ<$'jRjUU.ƙΝ;9쳹ַ&jӦM߿-[ ]23rFgp$}o&W\ J !/zzbz\8Ebns GBD"!jӦ?,NBv֬%L)Cqd‘?}8CvߐжXr/%<кaջyiJD Gsa7Wr f8%CJmS8vPӁDRE]SB(|H&~ g֬Yqm&4~+=y&kH6rK^~h U8aT5L8" ϲ̎j]Qs(]:c&@RxO9Cacz7-::܄!ќ݉faKc ii|݉F ;UPZ@pPDB!ز! R2i,h(cH$v/>Dc5&Zuxܤ;3ٹ-ok:uكb/M5lٓ<# a"+ln?Ƹ$Z ?N|NA}}= ܃@3ԷT%zm{7zs 23E#sXݧ+I3Lm rJh/.rq5}(HD p8Isp8Q#a<^7.Ǩn8@ c{D=XGM*B_~wwS&Ta?G^Rr ^zNQD/8i8i]A/oPz[ń kHD Eӻgq&vZ 7շ{9 %;0!>i.sp#p8/IWCUg0rD4`7~A+$i‡ &rDR]\q"}t{hh ?&=gk<ݞF֎:ܞfZ*ٱo=m 64#48ذbkqK8;&y}~ ƆDһ-3Ngֳk8餓曓~Dx KomS/l]sY6`Q^:$3X=&.=ę9EIlE0G"yDEwT~Dw97 x^즡֣4UHDwڢ|ô-Q-@6'3 N~B!?Q uTW&$O>U/ Ù ,JMIV[cVty4h"uL6|PH}`Ieشo2 y/i\:efn}Rϋ-mtvŶel zh~JOUYhλ=?Y!YvzB' L;+FoXGuH @Ͻj!5W z`) u9t;R>Fui8>.VA9u+uK2e@JJ3#@ePч/x,C NO( FUES_o@(jx=I~ v#AIDAT5(Fƛp1pJB~A 6 e0%)Uc4ɣ%F@gmF=bbZ?HRUeW# J^KDWr[Br2#?֏EHM@QYcQR4 @.GF7gT~nϢʚPl{/sV<@eFnV!O5Frʤ9 n ĐURsrQ1u{}mF LJFH>H{P'y.9D0PϿB(:%10_/ZE#P^QON7x0_rЁD sN8l6;p6wϿHɑ: i(B1;5C($;d6Gt%awbٱ)l6;6FZh ށaJ;oogx>6|vt^!tIŧXf,t#0v`D屽< *#R^^_xe$6)%63 L+lub,cJTBPR8m癩ʥ̪/%nfRJ>5v_fhZMş4=cD`|(C_71le._tGR*j${hV(e^:Z'faӣЄ䡤p5w=Ң{_1%OG#7$ݎ̄&R㦎hkFTjz%~?}1c5ѓғfQH TIIrd,̿FAI#zd(8hos}]Z<,I9髵ۂDHdd`'KMWlt'@8ZIn1IFGX} xKHJ4ǯ%3TM@BsHʒ^t^!A%tqm<'l#8(4ĕx)ٱ=#=!iAJzHhW<(#kP7 3Օ 2ܙP|yq㥰ߍfHNі.Jh)%G<k/I*ڵжVeԫqz'7br2Ǒ'3#Wzl-)c4Gmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???~~$??8 8? e? e? e??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9 PNG  IHDRc IDATxyOUu\p ,e/e (&BQ F1ݼLex,躑5Q$ATEAP``f髪U=tO7o^MHJ HqOI'EԤē"jRI5)񤈚xRDMJ<)&%QOI'EԤē"jRI5)񤈚gk1xR,Jq!DQÊ ?B\iYrK KDyUTRJ?fH~yH F!q)K~݇W_ﱽ+-3}#&4R"Mkٔ&\it닮эB1P <@7HiYbx$ U IWA(BAQ[(:P UuN^ŗ"hM˲AJ} 4 # bZ"RU[8FCBgL5P{]|i))bː&ҴbJ3$1 ݰ(~>5HB%) Hx%S 1g RJi oϡVǮ1LS!Et'dr PJŠ=  %LwU(󇟽/8Es^/4sXH4! 2L>ݿn$ ‹p!Mhoî1%+~iLLSyH$|h z-,)B"Bbjx')ʕD2s"V?"1B;HBU7 EӍ䋯wD$0jh}}^в u"c.5y1w"z W<( |v7ݙ=Bէ_mmw#L< +цx̙4to-5=xTՔ7; `:әӠ Hiy EUYӜ)%3߾GVՖs('KLY¶ݯ%&`FDxB-eD"B=ؓ"zĤɠh' wE%ltKF:`\,C )%I!s%1>l&%"ic"<$x#N8s/ !ت$m}v-!`uE))@Qw,y&4FZ<` 9B 랈>xv³Oͫ@("D &4g;ii#h^@Ͻ":X ;)-xy=_#=7_;v,CUB64/`絟zg̘1TUU)t}~[aDUOo޼yddd440Mz&/_NZZ|TWW'3^zO>$AVuƤeER}5HiR<2|OٳEl v]dՙ!իWS[[Kж6Թlق_'к3Ӻ#駟Gl͚/ ?{[v6pZ硇ĉ_>c (ؽgO1oE %Nu]deerxgضm[ hEI@O#-x{g%FZ=OaC4! #w%ϑ/;d%Kٳ'>`䎷ނ /lmX@ChDD,vDqwhKX g!CwM-qVzD6elz);`UW ms斫IzKcR|=mnRӎ6Qh؎ch=KX¼Npm|ɐQU' k"?"#=T*t'Y#"B4>"|G#Th"=Z;X~==<wlذq z hk[*=\?Az'͙[Kem9"ڻȼ~{Զœ+f܊&DĐruV U7*m"4 |amXv-ׯ`۶mPYSd[[B[ͰaQ @Ӵ6J.+^AARG s^^4; P!݈Ò+ !a BgYňEpZCuV~_j>p,ӁX7%7^Skx1M)ME/*PTqA\Hyy9_5'Я_?.]K#nɓ:7+ZFC@`E%IqeqmQx m)Y*aF_Cm}%5e/Ç_oHhJt9 ]e…\qkzٻw/,Y$)4h#fUGG<]w^~:W yhI!/"ӧO{VXHCShEQSbi1{Xr%3gd֬Yf<Ȯ]b NP0LU)ߗ<3gNď5=pPӉi7%'f H"<7z@QMƜ9s7n@ÇsvK/yEEE,[ xL;& 9Ys#_R}xrkE4x㯚aڴiz̟?s ]a̙1kŊ1e:j#v7m[uC#_r('x^`].**o$ - \ /7",SY[Ƒ}TT4 98oa̙ӱT7ܮ= \,.+ZA*k(OɃx\8GP@7oncEo_׸hx*3~DHD79Fi%GvGbktE">6~ի)ѣCd%yC$WpehVm-& tp@wNx-[9p}Y\\=_~t=@o8\UTՖSU[Ω*Uu0-<~| z Aosx&P^*kBJ""pL?;iӦ=z4]U&q9-9]92N{L0!f$gZ w98Tg⟶aب|u)6')ipJI'UGS_)sNƌh 'B\rIm8>gU'El9k<)bOJ<)&%g gVX 3:MKǡ9ӫv0w{9]E^N/ 4AӅhu/k_+pOSHĔ)M&LiFӿpc_+m9_@$B(*iN47.4x'T8b̟J%K<- $ NNpq+)M92x)Vϼ ־k[.Eai֋~( Õە;=tg&n{%lz֔l)Ͱ(`f!&4}u37%N+C}.dAnX0 Ϛ5ktJpY*A) o4DǏg.cѢE]*T]׵yMT֔QQy#ꑣ_̎=u B֐)12m`=[{LRq\/d?q֔m^HWs饗ESz-CeMx|4 t&_s:>p<*v&!,OڿPE9±NS,m[&L0 vqspbЩײ1I{HQfSHNf23rqrYE'b RgP(J&T  Ka1v(?i}dɓ|ܹ.B*P{Nqtw'!F&?7yٽtFQT|zx-;#>]0t/Gtg->?#`x/eS)GAn?$Pz|?aMmԻJ+hT=1c[ncÛi ՑcGe1*NB00L.ZĮ[}:O$2 " "N4q!O؆" 4w2M@ 3x@-cϫV/a翈;"wnYdgv'͑aߗ[-Q4val۶ Y!zb+4 E);իq,]cLl;`]P;nHǡYfd݆ՆQf&H`-tz/\{<8JWѣx999dffvIOOp*p L<*N Wg% Muӑ8BA84٤c.'iN׊ K@*Fp5P'NLrrrX|9 .wpob5*fGmdrc0|`ѧP!T'Ki'd'`ɒ%6#Dp̹`PSojh8t4iw-P5$ۜ#? ՉփJg+ˎlH4Bv{s%ڌfC4AzUB';]a6,2%s%d"AҜ(v^4mS. uI'JNj.&/@ @lƄ7-(nZA]L^֘:OUKy81HODJ7Wh"[7{),$Õ@PU%DA۝>R/34"*Tm b[#yR@E}~GVbEgMpV-C^h}0Zupa|+qͥiX޹ 7*bV?Fl3}G({B\%%#IOo@ 9ڶ&NDqP Cmm 0jzY3ͺ-AY0;;lQXwsq\0mE(ġo 9 Q3wKnn&MVy祗kHn:YSpNtg۶epX p2 c!ʊ2L0?y;47BY)w5C;:_~5M0aQ=/1OS|uz"**Q7 ԝWx-;U^kΩac!-z n/P4 C -ɦMP8Q_tGxN}'>גh;20L 3t*@J+{Q]75/w**.k_ѕԟ$`ON>;1{qwNÄee}u#Gx/9BXPQNiј4lpz Me ELBZ*k#ޥힸ%TGTqЧO.Sf?u(pʚq1/Ts-x^|i{ᇇ#w>^Μ9#Xs]PE8{$K@YEAv?i d7;Q)/N_uGAz'f>G(N~;!w>K螵F{\d. JCAU"xiQ?9!6n[hPJbW7=#:cd6丸 OfpꔏW0dHjoh ?nLIDATQi:'aw8jB P:47` ckfj{`A3IENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLh*"2" UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT_ ꪪ||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i ]i֡PZWjc/QQ:ӭVM?W_B[ZQ֡Z*uZ֟i/UZ*jB1j_Z7TkNU?_֡P֩kP֪?B_Z֟i /j &fFF fdDDdbDF$@$dHHD3220L3""##"1"# @ &fFF fdDDdbDF$@$d"BDB$$FF f`   WW Wf#Gꪪbinding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???qq$??G9E<@*@?3L?3L?3L??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10PNG  IHDRcIDATx[pUykA|fd  cNqoC3CdfbtӤn~i:2q☚P\   ns{>/G:>ogk}׷ַ%Œ'm,%1V {Is]_eyغu+ ࣏>СCݻw,@5[q6l@ss3saΉo3k,Ο?{[o5V^ߔx@ h…\no~󛣟ٺuѹG9#cZ<7nd޼y444P__7 x ;|kV-sΊgf(+,ۀ#S#B8!ܰc477>ǎ^KEkPJ!B)R|ԏJJcPd^-FR<شi---3ie32\_^KA)KD D &I}pgP(RJB{F/yR1(sv$ö8CPR\r>PWϣer2rB:~|/LY+2 xV-[b~$^8% ~G0R Jh]h?E]M#=$R%fIϚڢ& 5ADMT:B~{0on=hDLFS /ޕgPG)}z`F@qKm$ȬlFPqѸ]"̿D2EO/z 1MqB=~L[DF)#}k| gG^ SM3uʃ3rpτ 9 'R|?7ΞԎEE&ȝ|/b^ID׹qz ){f7`HPso{PB=`OAb-O5QO,x8Odt=IOe[6YHz=ƽ( WMB?NUe\2gby]LR*%i>k&,eC=\Ig\7K3~Qu՗,ZHG$`S)E`G[d”KQJ{aLT e f,l}1{6!WO?}U +\2jiiP(088W(t}l yxN^Tբo߾ahkk){eI95{vϕ_f橧BA?pᔭҔxjkVrǪ5A}}44_~^>BK~rݴ8vT-))el)8tمz \0szm^;v٩8y$]]]?^U,^xzMk>C[ׇ(x3nӓO>+s=Nj/xկ{gjH|%zm-y,>ٳgikkСCJGوg-Ä u W"tjر]vOϏm۶f 188[lW_}5PL̝;q/@Y4[m]:LaD!<3_`׮]<ݻ^x^xgy|>0/^!\ UVQ__ρ&|͛7hœ((3,Z|dRqQ3gxȑ# >GgΜᆰ_Vi:ˢ[G (9|7d\|UnW\u+n9QYt+kRY ,KMvྗ`߶q&ĭe7=}. V_u5(ѤuB vI+Rn ͩ6iWk4SZʮifR 4'SMnv_gC9LlyƢfR=c:ΠVb盷EKԏmzPpǽfR;͔ PE_PA#?Oim;'z1j)A2Kyt1PGO+J ̸-oFt{f3$.PI</*Guf#K!џ ,_#-b@L@Ü9|#HFE"utR3 BOs9&T5HcpL,\DPYy7Bğ W$@(ejbjb_ Kx}?\󟘟kga%^KhWΕ(azwD!\؍T,GxT ]dD,]3h !l3$>w_e0EGOk8ߥPt_6K83A-w2v`߬T((cT H;K,z;$88NqP, Wј#MTR7TxI%9~s/Dock~FHMTAλL>-&"]$#QH@E8* UzEg~~eMM 9v}xsOIY(x8G;aoKz+Ꚉ!(hjOK[!6+GWMMWE>rZu5%Kṷs.{nt+Ӽ)#t[ .\qmg$ doYA63lvJ)+=y =5rDwZ'Q{Lʊgf | vYh ,4V<N:s EsjfcEL%qxEx!|xjqt}k4xǩ*뻸nΊg"| yG qkpk&;4OO[񌇔 q̈4dS,]lfUNxKz9 ú޶8ҏ1N=ϒ[W"4ΒjΊg| Š8`E#*뵷ʆB.7o}xAJd Ƅc&A3+efffGۛM\W{u>3V/k1Wk%ćB1VX4.զ%݌̴t3i3c3'H֩;#+AUf`G#v?6G jM+ 8} x*1cAÚfix xzRWC[i2Rc~Ѯ,s裔b`R6lh*K* '0p3kn%}X$`u߅|U/S!A 3(inl4;#'h1)~{Yk2|7r9*6I˺GJ,XGj1~Q+ {aJ:{/u€6 x%5/}| x繡x<JiFb=yp× KCHdwk3IN`٢u"}|#}(}|×y4kď'NO rcqVޫ$9͕Iu!E{o:T4-R2^K~x3M^f,xJȝkOz#d}&xܣ8nl? #"凂 +w&_2UDcR/S3Z㓍#n ]M[a(حERiQdU,Sǫݩ@ G~BМTЙr燩>Y2YF%qܻ-]$Gq(|J탴M($QRjoZ y,$6[dy>׼MW(J~f&^T[j);22ytEc9 uRONazK!{YU a=JG@C/%Ϙr =Ψ]9d9>|xRTJfvDIT~lnhR3IfY*| ]D1QXSV?{yȽO,b!bڇ~%)[\0?OקL B!cLSLIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLW*"2" Uꪪ* ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i ]i֡PZW*iMLZj*5Zu֟Z_PZ ]jBUOW3?_j jB1j_Z7TkNU?_֡P֩kP֪?B_Z֟i /j &fFF fdDDdbDF$@$dHHD3220L3""##"1"# @ &fFF fdDDdbDF$@$d"BDB$$FF f`    W#?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??A*v^;n-@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11!PNG  IHDRc IDATxy|\u߿3Kf_$mӴMwZh@,>R\+ryD+(.zy|^EEQ`QMnRh,6KiɞYΜ{8˜I&3$u>}:gNo9|[O4҈JE]q<,YƊ4y&Ք;(K 3H(nfdPo+ 4a()6A2 ;v`̙!غu+v@/Y zuK1ary*/CTm@fK֌v{I(rWo+RXַ=38L։'^`ڵ\x,Y믿n~?/K_RқZ]˃&C~4=:A(S{99${s9,Z^{NRozjjkk꫹'Me3)¥R tso|;Ǥ$K._|׬^yquMH;\ PP $?=z#&wbrt[#`4ڵ]vaylْg/ +3!t]#Q!t|]ajwO?crO h۰8n.T3#sdiQBEJSB?@@'oSHFmYXnz+'+`V~mV4*.…P4 >¼&0A54-i>AI 1PH[.`LM?c{;6W]͛hm`ާH%dw%jb%A)e]q=X%շ@;@S|n|^q|穧2NE{{;_|q;2| 7wWbI܋b?ӻ}tK]I ]kGJ̙/;I.yĩG$r_||k_cC0hI|ܹӧ_b*u#+͛7tRٳg:?|e\zl7=vz<`N"ΈqG塇?Cd]^z%/^Lvv6{6l_ܹ}{Qm.+ Sic0@Im ߽̏ͯ\((#(//PT}Q}ϡ-^2yYpa$EK$ UUU&@X !Pe{84Td(;3@߈&<ÌHFzF*q$a挴NSS{ⳑ2b;:9DK$I "-Ɖ Q%ZA:f 0 4-+^!4`vtbdtHgl"Pwy|ƗgQ?Ϲ喑 6YӐp8LXS k!ZMS+'OJ[+9مÖpBu,Q "4Х4f$=:izxHЬr?o_yÒ[u ) J8ڟ լ%$`0؏r N6a䱝C N9!,f\=MzZ[cz8t=_ڞP4#q̪BLh*a=tY)M r fC34vcKQ$s7ƕ> ++IRxT )u[f;3qG#@C$ԣc OOƕUUFlPt$.sVfRjdri XkmPq{pK;@vwE& ĝwƍW|M? 70r6_RJctdyQ digW,eNգ f$,]M #OۧƊ+u^QQ}`۲qEQ~ߌdCJiN%R =70k/B(Iq q:Q%Gy1W^YgEݎu;9-"in?2tޒ R%b*]feʅhz\G^a1+yxW"'O8L=++\VII Oqb+Pw|d1_A88 PYM1 vGɅ&J Lfc~quV/ҡ,Cfd)1+1fM#Gʕ+Gfǎx^}J1J}ciӦnUz()B (+42<͙5䱣-rl:Dcc#999 ɓ'9~8?O瞋&H ݔ1|I6mWDGW%U)ΟAWo+Ey3@qOttE tal6٘,ıp7SXXHCC>/!瑰~zژFX0<4s\V<š4Ma wm yL ?6ms| _)σ>*x0ja+:<yֿb;-y"cp ?~O  ''z衘/>Q{|>|x>.̞0W5FjzZF'GJB(fQ/yzZj:7|y]wUoay7?wi %ϢK)ݢIMh?^{m)ia$NYȅIOϗ_WcηfcɻK^:4I4bLS褧bF_Wb#0O oJWtBj_Ϭb< xӂ\~G?SިҥS,8B7EcK0k Y 4/OBpm188/~歭4{NYXsȅ+6( "!Mah'kaMU\6: xǑ{k.# ,;?q֮]}&[TCͮ!"N 'LhA0a]ESz&Mc^˶m4{wm۶QQQAww7Gwވ.*ƲMMʂ()%\(ql[415bDUaP :~ Dᦛnbٲe;v;v_|MN1-@*"\f|.Hv2X3 u b.czZ#Du\kB}2GHu3SVٙyQ?M qyT:%9,!2sl+@O_Gk(yuCyRŒ({t=ta[2n:/C.;ޝ|q~ETm .*+3eE{Tp :.k1ɨo`c15vѿ~$qyq3xY47AK%ck2E]v:M94TahNd$}dPQ2 O݂@*uE"=C0q YKNv.W3Ó-pssxc9~w ;*~hEnˋ剿hAgXM|)K~r}*;HI@˒JoGYHcHRDXȃ 2rp)N)YХ #yy`YGO5*f1gYX4g5ν)%/݃,v5գ/&L\+Q u]"†M_hn?BC{ R8Gwƹ N~tm]?ܤf-} fLV-(m$}9԰ǞmƤpJatͻꊥx^^}̟u.q ?Ó[1?>U9o!'?}MT io?L)%5U+ѵD8ݱf)ެM p)n_g5 (dv{RmqbN2p 1h>Gh<6lIqxܙIB)%OWo+] myJ +M~uŒ mB!K T5hlaf)i5(..LFʷ?EOͦ' BnfXLUYm\8gn;p ^JB0 @ D2* iSWw7ƾnܮ)'ϑwh`;7H(7Me9"Ɖk%6HB6y (.vޑR޳HZgzC;FI@=|o"%tpFtSQ:wU3-~U  l p̛b;t8kCEp{4)s>z;ko7Unm:{q).\%5Ό דK^N~AO@$ &.k ;M&ytiAUfVAido1Q1R b JHVj8gQA5npz=iUѻ%]=oc{N͜ƖQi AZ+QdM*"3參MάٳmOk=Fov.+'?X9֭ysASs=| wt*[R2qk ej$\\M4Rh3$=}m4+nE!7/˗ЏmdeEQR7 ?)uz:8{%[y5 jBCQݝ3iD߶ PsģihF(rfVS3}%5ZK04hn=3ÓEoëdْ6Qw=?o|157$Q_n"mڛz&|vNaۯr9rنK4_NoǴH5UgqTW!;;p~nG ,9u ]lGBzxsuw#aNvީ>b=#09}!`HR*g|^A}:}≻<_R^>?̱c'ޥS\# subݹE_'99\ ttq{w䈘~ZFDlz+[Wc ǐ T/`CmDAGOs Mj5HAU~h/G]79ƃɬ0=SRXAQa E%O|Nz|wDkG}ĵ% ItؖӐgHɊTJd;U!e *PiXYb$;3 L1mvy4xdxdj!!?AO0䧳͍朑V"FVmu8OCY'썅H)gd=.C(Z(G@ujXOʩE5}1 {.2wٙRsy) y*JR_1$s ~>sOu͎oac!Q":1sv8,)%yӑR(A tkaxo]ިéy ]pMW5mHץks W!VM~X(p⏌9ei~7A!êolIDATI Y9ykk*aME P,BtKDZ굔 ^R9Kmtl` #R=LG6t.L˰BV44=LƻX8o9TΝ9=^xIR1,2Pݒ*C|fBVmѧysxyvPq,^Rc[1  !8ptWӥfZ;#H^ KMhbF\1[ -VF-%R7&S<`JwNsVi)1L1BPRGg M'ӝh?eh; ˠmJRiN7T7-%hw"EsIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLf*"2" UUWꪪUWUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT_ ꪪ||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i ]i֡PZWjc*j#SU5Q7PEFNZUj*jj-u U?_δM֡/ _jQQ:ӭVZBZ?BZ ֯jgZ֯/P_$$D"BDd`&f !"!##30L̈HĈ$$D"BDd`&f  @ &fFF fdDDdbDF$@$d$BDDd@&fWWf#$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??"2 @@@@?`9?`9?`9??@@@x@x@ ???333333?333333???#~j????333333? 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X>SN5sRG$|nW%eLg¥z0t `o<96&V' r(G ßKuR=US/Fe|㎧8uv؟Yn[5 Cw hM,gima1*9@:K i؊a,u_,ßGZZ}Cв$GU| | 8 O4 R{ѷi yY%!\./*K&QU6KŦmUqHLJn< 4\YwbXH/ Q\X-\vA%$ݰw9kiֶ>.\&VuC1-8Ņ8O)E亡z|HO #Wvrߪoٛ>gEqa!FWˇǕ\?M@#D-ux#lusa2t>[Ĵ_d:(ȭ\)J jD2)+GQ./m$>_x(B#9 ĤhZS1xLa@UeS)-a'V%L@$'7 x0(rOye8v*<\YV$IG'ݗ,c˧:}u.KD )/[vߙK 2EyXEw]P< j ]ih&q)Zڎ'm^ GF|sD>g^}_#GPMT9r]j+;XTMt"v=p"ȒDo_od% cSj9Z0̉+,{Y2'+I୏D^M%jCȝ6 覎ANF!w:Ќ(^O(4M`d Ф u'>*t.g|őİh躎k^߹AO"dgESH˥aRGvl*^l H.bG-{}xk' rv:ϱf;Sjre@Z_=W |' RRPHJWoNnK!4M\;E|~G axTZp ]oζHTtF:x̟Uq''YBS-8sS78E3'eEqx3mbJ: _htI ;'wSͩQͻyPS$4 <4Z.K]@83b1?(>ƣQ\{W}>w6@%QTaH G8kk_E='cM;u1ʄ#ĴqKf=P$"'|?:IM2gNXljI*-ܬb$Yf\3ޤoY&>o]StΨ_ShU_=EV(̭dfvxܴ?O_Z|,ăT;EQ(+sõw;OlgldfMZAq^UB b7O(ڇe4_z)oD}% ~gx@P7~_&H⼱ԐYĩ}w?$EIA4Y23'ws~QB.v4QS&V_ιS,j%h PY:3עiQy p)~6l~7"ɭu}߯/yWq<'/38Ϻ] v1n1H?3 (})IOckX?H4x-L?13(=/R7꡴#w ID:D>_EDa3vWrf!au8"^ҿܝZIJ0R=EiaP䑤 ¿Yp#"}g2~9.ՃnD9z;r&@ӽCYQ-~83n8n: e{Eg1f~ < S>`()z{xN7,.3l`0Hv{?_Msf,Z[C9*g$ݗ;;Ѡa/'>h1{J$$ Shlx%uaG҂ZD_o`BIDAT?Bl<./o=- .Fa? 0/3\."ѠדΑf~w`Z.+[f!';Y1tM׈D"hQ 0_%'Zo&obKDكeƎ .o\iDBEx%H&U7.ҼbIr0M904zzz/CAND5esEQTڻZzґ$lTD[07XK_'6pJD A0̑}4$ }ŭ,"7t_A,4#J{w+Ǜw; Oܼ+PHpM0y L)/ZW$ i0ZJ?1 8aJ)ɯ(I(..&݃F`dDOmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???~~$??Mb?V?aL@?@A?@A?@A??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13 PNG  IHDRcIDATxy[՝?=I*jq\vy !p! i>INNNI2Iczp$si daH2@h0`l]vUٵ*ioSJR>>eIOO$}`-о+х0t#t|b-̌ʊZ$IbnR@_}!̯YYpcߤ)O䙏g$$q?]eL(<H29n&/ڿP ZO}沿-qY w<bqjfi/<~룵?`ϴ`Niٰd*hؗFu3 !A/)/;cb>ip[֫ iTJaX"8&.} ɑ?ڵckP[[K$Ɗ˟*yOeE jH$ qP/>n"]<*?ٍ] uN" L244Ė-[.ͳ>OSO=lڴxQssFfN`s%wPUQQCw0 /k@ΰ bWJ_EDCsg۶m:th4:p$hMy\*+$ٞAB!~P;'d$ n P᜿#Oݶ\?nWAYY#55KعY\w>o .ŃK_5-A(2b`֎L=1!:$#IO,m 3kZCxO ck4c(b9~躞q'NTLC"]p%_["t :d0 gOvFb$+R(O>Wt]VdUKoI  ֙4-R 꺆T!#I:Ř3U4M3֪[Bbϱp6Pp[,{`do'"28fݺ%tus+_UqX/9MW0`H[ۃ,Z݌s5 '5%F 1ꡭPVN 炄RVt4]7lƭkta\s֭nA,ROJ*]zQ>_}a֯_ _<m6]?zUqDMM=sô*8?D%.qnkBӒ]#F"C?FMy̙tKF$B7Mm]we3>w}:tf*++ov<mۡz9n@G:k;Zz`p8N{Ohia m+̴ +um~TFǠ:0o@UU2̙3~8{% rQ:;; BS?$p b6}>oG0%sYQٕơY2FCRA 3OL~r֭[ٽ{7^z)/^MMM,^|+ϐַω'8~8*8qIFi&8 φdtј;CYy Y}ngFuSlE.37?vb֬YhN裏n} rID"|A#G0o޼ {x׸aM~nObS[ @`p{OXTtV Xu]<9߫ߦ{;3f>~[oU8|sSزe.uTZ[xw Um $dT$/~蠳ǃE˟X,6a6n< .E1|NA۪AddIJH TF|Ix4O[D"={Rx\xTUU~zm6y7޸P(ƭ^ ysnqf5^V ~Y#-_6,Ίcs~+̛WVOA8䈌 q YVPdRȒL@+lɵC~\.;::H\{!38h7s ˱OyY%B[<$[.<6d?\wY.[ܹ7o)~/Dkk?--7ll+ QB !dskD@2&ugJɎ? մ唗{x ?etśsW_k"Ǣ3a#"x'(7V>˒$4Z@B*y"(F 3x6oI* X)iqO%0AwQTéǎHDqQtH4躎$I̙U񏞊$"(8T~B0ԗD0CW$, =Vn0y(t|Nʝ䓑 ƚ$ޚj2y)hlfxx' (9oGKBt;bDVIofqy 8cF6Iвӭ.'w6wom,HMn# Tw{Od@'$"k2'y }>"^/o'Z=55n+' - Ȳ*)~^*(./DZƐQѾ\rN&)//D"NUW88ȳr <)kMeY)hܾYRņxUDy2--ֵwm'63.íxpB#;O]OFe>BHhq{'87V3+oY^X[1w`xG|WRq$@`+Қ@dc]m-d2!TdIq)n\z} OCLO9꿒Hx'r9d)&Ffy!w++1آei,\OR۞(]Z,ajn^ܑ22%, ̱.I| k@KY8ۓX9 OiqZ˜*t=Ԯ^ʲd[ _ye nt7<h\[x±{=>"ФJ&,+!~Ac2ZD2ARKPm4-}tWy?~6iòheɒl tfz IpZs=[? 7gIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLW*"2" UUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i ]i֡PZWjc/QQ:ӭVZ/ZUjZi֛BUW_UjP-i֢ZuZi_ ZL[ZQ*iW3?Wj_/"!"20Ľ3ȈĈHH fdd`&fDDFF$DbDF@@"!"20Ľ3ȈĈHH DHH3##32""21"# 2!""2 3 Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???}$??@ '6&@/9@?J?J?J??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14r:PNG  IHDRc IDATxw|[wh{ۉ'rd@ a7eR(])je(<KؔE+!lIh~HD=MGLG8x֩( ƌ7&H'x7;>4 LaRYQ߸>-XFzTqZ0jGLEU<!0 ekVJ%EU£xQdYVe4;6d<裧2}z ~oo׭c}]K^-ĻFV+(PW_Y_2CVTL?>K !Ξ-h=VOAFmGK%EUBْ<1-yK'swfҤbZyf7kΝ2mԲQ &.YQyoxEa"Dꎱ]~@BlBP<;sg M4 04 S)Z8 @idUUEttz v' شix׀?C|8b Mtе,`[=:0=niqc\{$a|bnhzDWCW=mmqy !VJFM~W7XtV}?E>wd;Ն3^r4l#뢭k7m]{̙z3/dTifc:Z\{WMw6{aK3?Y5au躆nэ-qvxly3[]9ϛԩcYdLg\tJo}nH|q'#u ?|%aEy i_)l@sns7ݑvZ{Mϼx2tLCdVJ Q3膆njFkG#]#NIP%7_Ժݭ] ,[?,H31B)LLL"iW;7U 8p 5CsP/=dIbo-oajcddѴ>~4 !*B^j,2N3'3^z*QvmZO7GUx0I,viJ斗3\Oy4#|BGO(,ß DnqLC'ERQ{MgM01a(!f5:VRGU?>ogۮNW$J.Q^xc~JEVshb]Ȫ mLC7tvLww[/Mґ[ k7x=lf{]]=OD϶笤&"HxWŵ{l'N͛Рm^aeŒ6j0 p([8ĉĺt=rLf^O>Hy]ahlpð$)+k $7l[ȑ:ν@#`ǹQM[.SXR 47w=fih d7K8ځDw4]KI`T3e|JB|񋌬-!3Of KrVwX d _yѩȪk$LfN6}{XLǣ~uH?f~?ʹw'q}^qH&NخAz{ K 9YT0O5NKk%#b Y7$$d[2Rː/i|G,]683b?ib[Rc;*"qN=?~MBsH"y/vT}0p3$ Y$+B!I9UW|ٹ@{{zN*U)S3b*$޹;T+;q̝z4#ٳIJGI_=ZK}h/'f9ء2}8Mh|=DX`tj-Ҵu/GT8 dqz⑥[{& Z,7"s 7C/,vp׾ '~()([~yp-KO=`5|" ۄ5s~B1 )$g}(߾zяo]oCGG+6%!I#O}Ȥڹ8"qOk,3+m%̭·ֳ~}〯=j% J*il"o:[O@-RC*u;􅝻7аg#ST,$?ʺu y*kg%Y鸎pI-KHo'ThxT̋J~*3g.K^1~Iı+o*i/S][ap̓ K0L;kdĈD8  ͉qAϽ}O㮵o87PKY7>{M\G#I h{nz$ҙÅNنl GC省xj4-T,2sU`:mM"S|[บ,uK$Z8ipU4]?^C@V F"JdOQюΣ8TR4$(8 gfEX'-HE2|E&$Cw_3LWI9v,ox;̦U2xAiۄ1Mݭ0(ZI 3a sQ^:EVNx)9ĉi{ֵcUdWNF\ bH@Kz4z(XZe5 OEJ]<%1{~l[gRq[?#*1ߟ)cjR&8剷7}S\{PgsqnnFQHnvFZ;RKFײzMtv`e'®% !(h>OɾGs~=l/y<4gJVlMPU~o+>ξ]pX<$ꜫhd-yz QATŋ)A[2jg(<ҢaT$TǮoK%7XzI:%/Xװ bꆆ , g5t( #I`td+R3l}ܘ*JGRZTE/v;)6E;1) TœPbĘ?DaZѴ=m;1->hXy)Vk \^:iXVqO$KFڑsxXڍ |I֯_σ>'ݕ/Sn$G;#x ,PU6 7ahz`|X[tzE4M$E4YG'Xf)oSZsdՄB W]u;v_.] x᝿d;F8I$E\OvT+UuʰB$#=ڊչ~]*c+ #%-_ Q7zvszB=r ;;dct[Y> G;ܐ{iVѦGyGy;z/G_;v~D;.Q}x=~TŃ*VtBXfѴ+NT_|aU7Pohhd}A+p.SaL%20b]#tvi#" pԂ 9r}$$nPH\}wZo!k}tvZ~-bnA-[yaVH ;Y-8s\64m&ZL! $IFQTŃ(Pa KK?ICgW\q7o믿Υ|#"1+;+ryEV$MdN)*b\WE _^:'ahvA|qJ&q]H̛6sk%KiSfļ_UQ99眓9@O] foLӪL:ɶqKIvGYw55593P*; iǻyig'_Hl+2kNn35 7NEHDeqO#BeN@4^|/sE柟keSqcnR?Nlaun Vr-ªߘ+Ը+u7opIc 9_nsKԗU`Ɖw7liϩb,._ t{%SFz3/<IQP&Ntڼ3Xwns(<(jk$$[@q5o' $rI)-ʝ<5;ں@8։bܖ 8XQ/L/7foM2?B1{Icn 6%{5hfrywIbOyľIyױ|) 䩮g+rkE7ܽU# /u)Yu^DT$8"-qlωV_θq(--+LK馛444pˬY|w*nliSfB`e [RevS-IDAT" SV2]WX]{,WBya˙ ޴!wY \,[ Ν^(u/^_̙3J&Nĉپ};ӧO>뮻3f-pKҹ3gΤ;:4 F8/LB$$aqDE{6cvGTKm|ƿBek͌?{IPG[v .$bEOr'GL:^}UiӦ*V%̄y*XPB)1o wѶ6 5Ȇ 9O4~O>K XC@EѳJlO-g8*5qLa VxBgwˀ'6?ʥ^:xSL:WºaUVM{!; s9Q7z6EJ*7yO0KLw iP]1Iy;.dSv\Hd?|7֯,&-}opgr 7ݝ*]˔T9CsDI 9bFᓐ$7>GNKš azKd'r's *f' gϦGdo5zw 2`b! jX\rCʉv9dhZ+׿WڔHtyt5j|yL^G`$Txh.Q8 IM2jgY>f;wod{zh@ÞM4l:{<'O$9.n{$2mj|~|ş6Xwe\;dMd:yVpR\_=_~NafH@Q xH'¥"'4Nt \y%˷WBjnCt!/^iY_ 1qyl$oS;z`Kq5 ˝^%Fy j5Xn+Vp䒄4N⊬SW;#VB*dRu"&nl}}{<%TUKe;s2^cX1Ң* abyM?{ihh/xs{DռΓ%$@Ed>ak&d`J<}Ɓo%X*TCwBU*QUWnX&B SRl69asr] ^&CضI-񕯤A4d Ie%í~WfΣC!d)y>~_4 NbUW.;NI83y9ꨣ_M,X_$+ǡ^dYF74ڻv};d9/8vvl.58oO~d}ѷ~;UBofѢE)d9kes[ÿDB@U<*PdcXC,~"^Ջ! "m|BY(6U'53&epX?cJW9pO]{҉D; v ^w]gQ}v?d \ !8 bi-\1:ƺX᭡\^8_|;#h'ayEHHD]tt;ځSobcJ|n|tFشc Ue#9tCqɬa6fO~Wq=nȲؑr9%ĉuJWmzbcJxCC-v'{_]1_̱_dqdnyhnNVQt#anl0u|Sswƌ]t_3jhFX}=q[y`ǟg5RGrJInTaTxx[ PPddS,=_"Q\3!>w%hI%Ѱtt>! t䍥̠!so`0כ=_Ȓlv."˃Px{X񭤅K Ht3`ܳ8IC_BiQ|goZwAxQd]׈ĺrW $YI瓬y.{3&6hͷrBxZ9X,1ouJ@"}rKx<躎t E NIܧutx,$u!Lsd00L!#&vXPxtAܖ=$+wQ p 9^^p[@уi&weRW;Ͻ`\C"NYR%aJ7W"L]b NRg> D߾V)^!c-e(>a7d|5~L`x +Mpq{x^t]'e:v]&J'dw(3Fo|VMufƤŜu91M%P2"}</ي`Z^S%G$*g g<ozwV%Om5.X_[N4ލaba^x^kl2>4]s< >+q1͡Ul,_L$z,c Xˬe.`t8y7,I_rsBcc;YXyq5eeȒD[Gm;=zT/`4M+y|G#2VPyrα-G-:+ɂ= _(%4|АeSd:FVMb,먨tvuhu=颐EbRRj0]1rX7&=OnWjLs+}P4I8r}9wC]wvUSD=ZUF+fLTdEI)<`̜rq0 8t7POαQF݊C ymzq ۫tRMq" a'L ypxAӬG74N8ˀFL E&aʬݘSK"GSoEnle^!0 {☃2"wrt=fĈ#D(AF5tR&f(1fzyVW]V:$4^것 kz c8w#G~r#LjkzMr)Hpw3W3 $x^`ѡ_=MO69h־n%?EVPdj!#{Q*((Ylٹ.Gwg23 ˪c3yʄ%V.;ab:# E6BElb^L`O$IFUײi 0?f-;0~L0Q/p 4R Z;9! {)gfgL7@7t [! y8gl71R9\!঻YuA0#t9DA[P:ynAgCsŌG'ʞp%**2YZQy;S G-Rv8{n``L=+/g>bpS0{!84*qT!L6\<b, [6M{`sR!HHTJE"sFjE WOk^m Ͷ,0ذmEV{Dɸ]7J"3&.B7xT?AQTTy=보]%>q!gG$Zw ur%RqEU}x=_x*^xgWPjK"dDfncq JEsQ£Pdfj y)'IN?x[3 Mv(|@ A A1_8{+LV@{Q .E-{(jmT H3Mc ^;8+&/& y 躎A,#r? cY|74?Ȓ:_謫mG~|^Տ X` '  ~xZ?r;din&Tg@wΎ2:Mf[RPL[FYK{^ #+"/!(ţ(U{vgo⸅_mXg٧[ETX']l- C|2@CY<]@Ѳd% B2B2exTc^X7 ԬX`;|εyytCK $5.t4Y!/(Pgłk@(hMv4Ge? uiIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLl*"2" UU/ UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQT3/LOZP_B֫1j֝i֫ZjBj-u U?_δM֡/ _jQQ:ӭVM?W_/c-uPj֦uZojB 514TGZBDB$$FF f` "!"20Ľ3ȈĈHH BDB$$FF f`  fdd`&fDDFF$DbDFBD$DFDf`@W WfW#?? UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUbinding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???qi$??h2@^4@@G@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15\+PNG  IHDRc IDATxyyz54hV4b32H br/F8<:q'81\ؘl fHm ih4ٷޫ?j{ ӯtWw:UwmG!pp {>Ǯ0G.RGJ]ȫIdUt6L BqP(k躆.Ukؗ$ GZEqP\XAYd J;~0@c3Ѩ!b"?L]Aa^g[1h:/!66Yr mի.u4-B8$QvĘgδ {lC]7p쇜m9?MQx6`OoBJEX? QÉDڐrsKZQP@7@';?HR@$)B )u襔BtBG‰17b#A}߾i+!& '~߾τ#‘E@  &I*@wȾ#."S+j@Hzw7}SI_|*XzT-b!@"wqvXvXދ&˝F15}_8?;m%a5lJ:j~|m8.'DQS* b YS˨1R]ȉh  b]tfړY]7Lz~9=+Ms q:\ZW9>ޥmX3tš g1]r;09L",yY#a5>atD=GCZ;No'Gxk`oբ͌˟t Y "f+q{t@ҸbrADGG%] PR8G[D^@T @ 9us$0+AS $~q٥1b#H6iׁ:=No;CC 4>n\Cޕ*{vAiwE(YqbE5'u䈈%DP8;O T[@q[ [mTΛ.=REq `{WASӶopbYpsLP%t$<-F51a3q J=#`Δ mnJJ?:/QC*po@(q2:DŌ]]=Hd\HjᵆBbN˯Zy .ÅCqk??[1oIsGo$B`JżAgiwNM)<9K'e՜:!~,XOlٍqc%_@TT5IJ!xm1 ;gY׼o!KA#OPqÏo(p#}-2~Ha$ ăpGm)[DD Q{=fNYf GK?c Ņ7tZT^nL\Ԣ0\ҏ!u(Ҍw=yR#hHAS"imtżuƍTt ѥ`ر}L*/8jԞ؅.ufV-Wcha.[v#_A=b((}_vpvrIt_vͳ ؞A?L'1*6 `0;`!:zW0apq:\dÐx1B"lc钆y%wiqF1g;<./{TD&rL)r$gYvJj(짣T>>|+. FD2˖G_(B0C2|nkbb9dǛO'¼2_]ij+z-慷tIj;FEؒB0KG9J4D=uE|kLhr>pZÍ/E ffaȘ}IiQ%% Ո"&ܨT1xJL$y9P=6롴gJ\<ڼV즤pbg11'y<M'j&YSs*fÿtZ\̌t`xӥ̫^MX)P,,@Կr{(6$MlzPʋ;:YqY%&ٷq3Z$2tA L0tZe @}+Vt:QI]:p{D0mR 6 T7"4a ::0֝;&ŀvt+rL3*N7.XAQR.-y^XvS?R3Ƙ3{EUôw7ܾe(fiɳ6i>Uns"3j a2\ BS-nN-ɣԤ-QZ8q{)B"t֞'Rn´Iҏi0ާ즺rK9|zv/DU!="FSg?7^ffv\o!FlOZ;,L*E_Ol2KmU SY6a^am_}{ ,Ecơ:R_Ki-|ٖk38xnzB|."7VZڻAr P$"rF FjN i^D- 70)R5}KnU܇FLƨ<>hh {:w ܆qg]K~N1yedsдNꛎA0u-0B m4Fo8+`.ho=kWsiO()mE8'*w5F8 y9ƔڛO;i 8I7#S' 8v:N7V6kjF[W# v&'Gk~yj#b0/P\nfҘ:p+RbM'q,E]x\8n8D |6[qkiH#-]Gfz)iV+m uZ&]ۮg~ҹkq%q%`/:[1f)=`ؼy3O=>/-3F"vբ*jQ!Ca.[z#=ape8nW̲FkY{>pa_VWN 1OgW2Jk{I0ӔL}j F8ul\0bμ\gmx ,o1|^As nULn6(՗wvJ~noJ:dcG/bfupu {Yƚa[6.+b͒vdΧ(+1E/bTrv=CYYuuu|s,}k;#M6{ /F p՘zԘN,a{ !p8St.1iV23śGt]p)pb̀YBago\_E_|3W\3,|q|@橧bXlڴ~%=@07TSj\ iijPiQ%L٘i9!Mã6H{pկ Ҙ￰};?8wo(6ȯ&Xe8H{{%_HS:GNe.5jOUa1ǖ>:ֵ")hR iMP[9#eD"^}WC6,L,MS:?WKcK G _җ=tԩ[_<̛7n?I4c}.ExUֿu?!ΩZ;^" F3v;Et4߲f6i,c*u]p1%5F.^>@"hzw=c+iOҴI㯪LkYŽEER7R*J[RξɱE)|o؎-}9㋫Akvby30 NVo_'};3Ow-M6}&]on/-wTuU5'.;mg\jrh:vD -4=C 4]#0|&u AT8. J 9y19B‘ g[F  6&ۿ?p< fv=̺ fAs|ʅ̜xM[.(ZB IDAT!%BV-D(좫np`SB j< R:)**￟K/z!t]Pt}.;CڮG2Un`]55c.bWգׁ`gOz2"0V >GcA Eqf(P$@Vؙ)KSnJ)~ 3R ɓlzBV/6Fy{Stcr{ٞ<F榔Can *껿 ?=ພW 9qCw҅/vwuo6Z~:K5װi&]}f/})}ԣ: +\ 4fxow}1$ 4,YH52*<]YYI5!۝w)o|3 ;*=}زes[<ȥôwRE*!S:nrfI+[z^Αٞ\ɓYqes>A9W_M6d`0H$2"mYY'{$+r䤡WAڵb.d' Nu,# 3$Gzˑ#a9*K6DCUXj# 4jeQ'm|??;TMS =BRЩK-*N:>Y.cPSxXWW6W 'R_tpxϮ*/ _v퀟'J4t0s05LD '_L(k?Lɉ|`ưk0 dpU oQHDb\8:GVJ/FE :x #joOt]dg۶mTVV~HN0 8?FQ${\H EWQF@\pøta1k֬8g ROp 7% |2K|wnm ˖?O-,vEg1J= p8匋'a:QoYESȒAQ[[Kmm-s̡&W_͹sg2dn7M0p<sn`dqKlOx俞b_/q‘~T-L8" Q1jYb\JU8|0>_o曉|ضmۀ} 9ı0F Eɍ7J^zIΘDK-vt:tK9۪7ߜr;W_}|<|7{}Ex\(A('Jg J7ng41\뮻ghl1y̼Eqia?P'CΝ;?~Y3gڤXFEFs~kx |o9czJ =SɓNLAmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???Ҋ$??;?@K@?xմ?xմ?xմ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16,PNG  IHDRc IDATxw}?oU+V HHѫ1HM . 6Nr ؉k?ď㛸;0l96 # jio9̌vw.N9w~ +CU< ah"C^Yr!01M!B[9]y5B8_poy3E7=IiρH]'_@Jkòˋ:wHKM,zNG_~Wlho_[{ lXvYi#I5 m45 ;$7}hs&smʼ<!LZ gòYd++_NNvj!o#•Hν&qt=XԒ>)ݟ@zVJN4F#,w.fN<>{린#so)GZM҄ml %y-bÌ%xU?m u3 Nz'-pME͝ HX͛-R}X AӉWia"±‘aLaLr'-y 1m"mޣ-oHܶq,hfgI$*fDӢ w?ELoX=Kx`H H@XsSj<Kx=>dE+yĴ1-GHv6%-SlZum浶/m+`E7SKIoY~o `4w5[X:hlbїmWmmmSdm7y-KKѴ14ҋahZԙ[XtIĉ_ =mn]&fk2<K*zho$E74t=i֮Cjޅ),W0MLRm ٲG 09kƢ͛c:Xy'Fj a1LSgeX藍0G[0l)``&WyOv%5IIYRKR=$d4Mm:c(ԇnhfi#g(}X6M40MHFs@;m]M1j\0 eק*ap却 7K:h?uMl8R6{aKc ò)L|eEJLfםUN!0Lu{1n,%wD a8ciQ>ȣ %BF(3G=aS R2 >$%HCUQ0 3+Iqg -2/sN%n@=ai:/\$GU#I$6B PzB2T2 T|ۢx! HLHylҘ3MΞEVeɵӔ*Q/ >fj`v5/w M"9XVD +EU,8R&+EU<aruOƃ age톻U RW3wB7L-.\]}%s)ܲDU˕'cTt6esDT_0|_eU$!tˊhz4 X3;# 'Br7awLe;3{hͫʲ@`:؈:^?3Жՠe%U@Hغ̸*fR_0c1` h,ĩYC)*Jk@L܇.A8%ahߗՠ$#K2m/:ߒt`vB(@uUgTEcHlK)pbƺz CαZ)5oܕ`:Y*I{vqWn%$YB4o(C7l4!a;]XhT`]+ҔjZv(^"oz1AKBV]K}$I#ݖeʃx_a|7zۘV1:AV5B1(Z׉a趩8POO>ouHOn^dIb."I$w.$IBU |frLC'PZ?20hl*"nx ݿ/:7\9t]W/| kJ \MҤM@U uff., }m{s뵂 zɅq({NoGzQUm JGLf8բcQ<{R$ Gk96kbחт,IR(}YPk u7pR|+kLѸLQKGhgIq0z._Iiڻ潸.#+GeF}9:}v1CQ/o)2-S iȲRбPxo{%Je`O7:抚zdI}@yun6ɒ_|7? D\0jңR^G$ [pϵ(cC*93Yv LёDm\y5Տ$HOfe7HRB:eo=ǯx*k9~+X L@74Te4w/ȸy;֯DUĴ'6?,D!_MgEsyWgC?lq+zU|w'e xx=>;d̼կD a(WE]xͶd([PpϠ tNN\aЍ,%*㜙Qa4b$2Ho :gU`h\5|yg?{sP?A5<YeŴvgˊ<떡(~9X`MϺڪhlւ1 ]k˚l&kȲFÌd캳[6iĴC#}#X ЍçOywM}?C {oGM}ipFZ?7ܰo\]w]Zoĉua8܏GЍaR̮[$)V`)]C3r3إ¥?,)F@g^%4 Y2V_KoW׽ꫜ}٣裰}{~v54K:)Fu^zش)>v<@YY g(SIKPdV񢮪G\(C ts߯sA`E2~yƯI& &J \yu_Z, KxO9w1v츇}=E,[3~ BPdY3syaTڅA0 41{{c>,+N)ڻܞ}x쨹ij0/| ԧ>{186kEQ8au`|o/'>MqV6l(V+jMJrN+yf,n5#r&Wm ꤣxNYаYьEӢi9׾5Ee5?NSS۶mXk;^9]z>: vNz_WcK Qغx:tS'ea⬣ $@4Xt]C744=Zin|nIށvvƚ3s99g1tS+{% o>v1sz/}N7<Vqx\yrnu#7cܿKT*y%x .p8Ν]2?O?8￟&?K/r͛7?q'}K/eCY6%U|TcU_JEi}C]C;.=C0ZrpPW3I}7z,mĉff?SUUw]KKK ---i9y$wu|~!8P[[Jgg{cGI1-xPP^ZbB\xt=PS}? Rpz;c/m6~d4ѣGٰa˗/'ӟܬse߾_ub'xX-? ;CU<9Cy"s^`EgωC@++'^33}O?ݻ=e#GOlyՕc#Y'Åi Ĵ C.6qndY0 zh9ʡW 0@ I^՟+^"k+W@ii)v%;d{?ND4v0cYּ`$<@4B7t0iKo}.jHݶ?$AOۨt| "+xT-vSE},Ul۶5_q8a!d4jAKv?t0Lz3>->}[D= 2/6QӧԖ) $d;w;sn?w1Fba[1-\\a ΞgAmU# JHTt ((<xj.p^#ξ~~[;@e%Uˑe< m]tTb ,1w÷ qi:Hee ~rS\(mG|Uo BڸU/-] IxT/Շgբ MAA_YLNQL )eNKν`% ^PCD`ՋPT/k\s~O>~~emLp r mͬ$Ʉƒ3'[t6 d͒"$l۶ 4P KJBDCEQ '|/}* 㛔eIRd,GB^ٺ&j0`p{ 7ZG GGؔ?>Q(--LڪFdYAya"J4qsplpt>3o{??<ղREL/+]w*ס HtHlp]=O|E#/UW'zHfຜއz $/y -; G,#K2@-Ho⋷pqynjJfM.U`:]=}:H^L0 y šQ=7>(+b2't~sE?{/Mẓ4PxBTv^|J\c⒍)^\tװ*6\򕯤|_,ƺbAڤyS]ԫ暠cz=7AC}IXLVWW+`0ȧ?iչ#Q5 t_wpڔ#-;vpw| >N xmh 8LǦt啭2_Jg+ۆdg_kW^#֝uX6<13rOuٳAgڪF1,1~5}qFho.SڃD|[c0&pJũpwd̸Qdܹ&UGL# --0i5%K˲Lk0my#é&?]w{/[neʕ,\ku}m'\'ʕ\ ,o~u])uL<_=(dRIBڭ NSNvNjh\eeͨc5t w`jT1ȳKOUU+?JzM7DGG/|[r%e馛ظq#V;{pȌO;CKTIJK*i:T,`YYt) \X!STrʆiБEϐI'ϊ[BVkӰ͛ !Qqpf֬YG~1 |s7r~dwIMM <@ڵ/+̪M:;3(vl;6m'<l{kvG:KXgSYlxTZf?|/~ݻiӦիLUZ]XeYįAP5:9bx=~AXV/nqhza[R'T2rN7?ѣG ֛[ ,^Kxa*]ɥ,HH/BD8!Lzڙ߰:`d$v/z "?k `5=FO. ^78ԭ=W펗;6.k|PU^FBBe1OkBXķ[gw0!gĴ0Kt68.B38wۿ0Hkqq" á~[XI]а&5ˮQ$ŕ@tlp\- psASW=M j_E"01Lbxxo|A+6IU!@Žu,纣X^ҧ%,[[,7\%sϱ<i}-rCQS[hJucGAB"+u_g v< $=~es|q[nX̅iE,wcAcҧIgIFeԒe IDAT=7qpּs:s:8(y+1),b}|</;|+hR~ؓ[fČپ2;92f}I3v.Db!dYv }[쭼l:V10{8}l[R&Bs67tOU<6m)J.;"}GYICoϽOUطSbI{5Z-[#D#{ItfPtK])#u+Jk=)<̜/W@Gϱ'q8֏H ( NMi9ŧy۷oK.aΜ9e]2cN?q%q,{PJs-2AGÉp ˥P*JSY> /HisL, M,{d/^L}}=UUUhƵVl%%KkIo=iK=,}V6 )qxY`31=!ΉKi)LxE<)lٲ2~Γ ķBDmI\%gƧGѴ֮Cv8oX̻E&̚5Bnnrw:C~\48j`@Vt\ A82*G^~eV6 W-jaīX/IC^fםʅsYyc"%hӉ]jЅ#p{B;['bi9!Ƅ>@6BvKE)% %#-opM@6-1¤ O~Ƥ c5m7MdIaò's.~^u(?яذa{7'y}IaNĉ=Ѥo4/}K(Ν;ٹs'?UW_e;F=؉äǁz.Œ /˿坆I 5U V0Y2l^[A` =5@AVs4R0V*JP8Lf!L+"!Խʃ)m _; { $E$ 7[͈} #MWrYbY$;׉ ~TK_z":S6SjZB<'7#IL֓q(-Y=A[ !su'̣(4tJKtum?R+ٿB*-ad-mҚ$YU)sY/ث0)g풋1I9E `*&ƣƱ# GJ񨾤4̔^LY`z$9@Hs D,BY%LrxrHh`dkBQɳq-"˪OwM< Ǎ]Ί^LE*T%4`3p BYz|(YV;9ɴjRv]+G'* a뱔B=Tº[;R=I C]ުFKRF}B)MKҨ 9Z$2개(<v5}K3<0O;8-ZBC.,601&lu(Iu@%YԽ}~o -o鶼ł#E\ 1LmC(%I>\0}l84aibƽ6! 8{B")69f6-ɁM6& %;*or & o[Xj")v܇og=IzJh&K\f*U04 CC74NY%(1*ɊxLQ![uqm6)Di0 PHI)uz;ۖdTv:y/nSz'AдոZJ*sO{^)@0Gܼ,YQ^M`KBlnGGcDR߬w9C5 ^ID_F(LՋ" jŝU-ԍ(}%I#%)eP|;@`q_$I(U[POܰ.O"I49%`Px.T`mcc=`U6 B,I n2;Q}Sϳ=XO7j7GIENDB`move=1000;blend=1000;3KZLA_ConSurf_DB_pipeRtf 3KZLc*"2" UUUUUU_U ꪪ||ee PPEFNZEUW_-jmj LO( UZ/S֡Uj֝i֫ZZ _EG ]jTQ_Z֟i ]i֡PZWjc/QQ:ӭVZ/ZUjZi֛BUW_UjP-i֢ZuZi_ ZL[ZQ_LT35LS:7TZj ĄHH3##32""21"# 2$$D"BDd`&f  @HH3##32""21"# 2!"!##30L̈HĈHWWf#?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco d 266ac3'*-/2ps 1ubinding site for residue cl d 267ac4j1ubinding site for residue cl d 268ac51ubinding site for residue cl d 269ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco c 266ac8&(+-oq 1ubinding site for residue cl c 267ac91ubinding site for residue cl c 268bc11ubinding site for residue cl c 269bc21ubinding site for residue cl c 270bc31met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES991met->mse selenomethionine MOD_RESDD1met->mse selenomethionine MOD_RESoo1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13KZLB1\\ <    |ee  |` A$@h"`Phx\hhD) $6&@ Q"D%MD&ȔY(lقQ$FMqUa *N*]:xNM:GuYeӊi GUSryUZeӧYe[PxӮkMSO#UUVPBR,PLm(Bu$dHI(XHD ]t `}FP eYmN'O! "dNyQ8"<-6- 0t<-# JP]h( 8`0 2m֝mNTPx>P|\i*`ɳ&L,hr812h٣&TI"]DD6`Af0>@] "mN0Î뮴YaPhaY2 ˮp]u]uBm66,˨T :ӭi]u&13LjκgNp!8:qVa@@]ea%DdRE "@*8*`@xqB`! 4q֕<PYd(P$Dj(SB0tbʖ,\2&LLV|gџ ϟ>>}4hџF|4gQϣHQF 4gџ ϟ>3Y³ϣF3ϐF 4`d(ѐFh7B tB fjVUI$DDURI*"""""UTUZTUI$U*UU)$I$IRI$VI$$jjZU$jV$""""*UJUTJZUU5RIQTI$I$jRI*I$binding site for residue aco a 266ac1(*-/2Gr 1ubinding site for residue cl a 267ac2f1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue aco b 266bc4'*-/ps1ubinding site for residue cl b 270bc8""1ubinding site for residue cl b 271bc91met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES;;1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESqq1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13E4FmK4K49 ji5֟Z/-uZkU5_BZBjZPZZP /ZBđ"H$D$D$"$D'  fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQ$I$""!BI""I$I$B"""I$HI$B"""!B$HI$!I$B!B"!B$I$DDB"!BI$I vbinding site for residue cit a 266ac11~binding site for residue cit a 267ac2"%km 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES661met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue cit b 267ac4"$lm 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES@@1met->mse selenomethionine MOD_RESkk1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??? SNAMNDIVASTQLPNTIKTITNDLRKLGLKKGMTVIVHSSLSSIGWISGGAVAVVEALMEVITEEGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYPNVVRSNHPLGSFAAWGRHAEEITVNQSLSMSLGEESPLRKIYDLDGYILLIGVGYDSNTSVGLSEVRSGACELIKVGAPIIENGERVWKEFVDMDYDSDKFVEIGVEFEQKGTVTMGKIGNAKCRLMKQRDIVDFGTEWFRKWaminoglycoside n3-acetyltransferase; chain: a, d, c, b; engineered: yes; mutation: yes __HHHHHHH_____B_HHHHHHHHHHH______EEEEEE__GGG__B__HHHHHHHHHHHHH____EEEEE___GGG__GGG_______GGGHHHHHHH___B___________HHHHHHHG____EE_______EEEEE__HHHHH_____________HHHHHHH___EEEEE___GGG_GGHHHHHHHH____EEEEEEEEEE__EEEEEEEEEE___HHHHHHHHHHHHH____EEEEE__EEEEEEEHHHHHHHHHHHHH_ ___F__F_________________________p____FF__________F________p__________pF______________________________F_________FFF_______________________________________p______________________F__FF_F__________________________F_______p______F______________p__________p_______________#binding site for residue aco a 266&'ac10F#binding site for residue aco a 266(*ac1 F#binding site for residue aco a 266-/ac1 F#binding site for residue aco a 2662Gpqac10F#binding site for residue aco a 266rac10F#binding site for residue aco a 266ac1F"binding site for residue cl a 267fac2F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine !!MOD_RESp=met->mse selenomethionine ;;MOD_RESp=met->mse selenomethionine FFMOD_RESp=met->mse selenomethionine qqMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESpDIVASTQLPNTIKTITNDLRKLGLKKGMTVIVHSSLSSIGWISGGAVAVVEALMEVITEEGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYPNVVRSNHPLGSFAAWGRHAEEITVNQSLSMSLGEESPLRKIYDLDGYILLIGVGYDSNTSVHLSEVRSGACELIKVGAPIIENGERVWKEFVDMDYDSDKFVEIGVEFEQKGTVTMGKIGNAKCRLMKQRDIVDFGTEWFRKKBaminoglycoside n3-acetyltransferase; chain: a, b; engineered: yes__________HHHHHHHHHHHHH_____EEEEEE_GGGGG____HHHHHHHHHHHHHH___EEEEE__GGGGGGGGGG_____HHHHHHHHHHHH_____________HHHHHHHH_____EE_______EEEEE_HHHHHHH___________HHHHHHHHH__EEEEE__GGGGGGHHHHHHHHHH___EEEEEEEEEE__EEEEEEEEEE__GGGHHHHHHHHHHH____EEEEE__EEEEEEEHHHHHHHHHHHHHHH___________________________p_________________________p__________p_________________________________________FpFF______________________________________p_______________________________________________________________p_____________________p__________p________________ #binding site for residue cit a 266ac1F#binding site for residue cit a 267"%ac2 F#binding site for residue cit a 267kmnac2 F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine 66MOD_RESp=met->mse selenomethionine AAMOD_RESp=met->mse selenomethionine llMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp 3KZL_a3E4F_a  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~@0K;r@ffWaminoglycoside n3-acetyltransferase; chain: a, d, c, b; engineered: yes; mutation: yes3KZL3kzl P 1 21 1ByB]/Bq'??d?abcd?????? AAAAHHHHHHMHHHHHHHHMHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW"aa3KZL_aali_out         fffffffffff fffffff fffffffffffftfffffffffff fffffff ffffffffffffff fffff ff fffff ff fdd d         ffffffffffff fffffff fffffffffffffffffffffff fffffff ffffffffffffff fffff ff fffff ff fcc         ffffffffff fffffff fffffffffffffffffffffff fffffff ffffffffffffff fffff ff fffff ff fbb5         ffffffffffff fffff