4_3.6-1h/data/swissprot/ 3EDN.pdbdupa 1QY9.pdb$s[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of The Bacillus Anthracis Phenazine Biosynthesis Protein, Phzf Family[/h3] [p]S.M.Anderson, J.S.Brunzelle, O.Onopriyenko, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3EDN" target="blank"]3EDN[/a] [small](deposited on 03-SEP-08)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1QY9.pdb3EDN a_3EDNB1  1QY93csgid.pngPNG  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JVL]H~áw:sS}.z@M~2F{dD[0-IcOS*)5SQ6Z"#FH QC]$.LO>y hȱ9UN.jyS<Si#*vP`FZޤP=7F 4"ƥllwg;lFQmZd9y=%@>F_4v2L5C:]֡l >:ytW`ͨ>Td|SD IFFv嫛%u%֑g2qh%ߠ'ܶv5_W徚Q5Tv 7l6qź>=:gUWQH&3Qf=Ѽ9oVL-bU33Sfd3L*?*)r2ejotᮟ ˖R,||&5寧rj|p(=ݸŨ|4KOZy|Q7H5ߨ?xP0ڲg@W#l+?jYr ASOmg3UjAG2rfc@z0a^F>x3ݝ:Jh\d-cw5pJ/zsbl0U>ppS ݇Zm'W\RТ=ϟֱ7 ϓ@ռOAÈf7Ob63y]yw,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???eWOe$??`;F@&@j8@?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBiological unit]/PNG  IHDRc IDATxwxT?I(" H%Cz! & ʋXbAAvQ:RM6lI%t3Ϟ2ܻgO3LhMwa hDŽF$<&4&10 IxLh4LcBa ;*Lg[&4#)MݙA ͍6GaF GN޶=?~5%Dӵ4 ' *E)zM}2DŽ4bm~GJK8~h?W4{54b…رu.e(_^K=` | Nb@;=O eP^^w[ҥxjF 0-M/+sUCnm+{ڶG~@_SXF?g6 NV6:It&L 8I7Fq V63>K"J|Vhe+KG+ݿ8@IYU'=(&Uw.iȳ67_DD'/TYњ߯g&b褷OXwwld '$0\OZp\&<~ŐiAhm=%:_#ul.Ul<]ln }< j섗IxMBꬊE+Z|쥓tBǏ7_$jLD O2YfDx<ztDh6ExR/%SV\~({; _ީˍw Pj3F&ώrף%8'9(xm+l > ,* `#Gaެ-,\N ']m3HA`&OW7/l%vp~8{L7 E&֩/iF>WJ(/)QTH%.]ˇ((_l[U3hѢ>JE00d%wҹ+߼1N1#)A8q7 gO @ÚZul.Q\TL+uz ѓ@6<dyn:*jHvK٪Xy1<Ϟz"xǧжm{]űw=x xSހ $<7"fPKx2ChN,׏ P9"mOn)\,GOCdz**Ӭy @{MDhGݏY3 M\*Sqt+5wJȘ?5@gI)>Fa1pI~ I#.kVҧeyn"Tjee%f9{QVZ®wYrO̚VeXW _jC;nۙ 5\u؎_8/tfOj}^P[^46*pM;W /]F<s70ߏʱ{M¶NTWDr'p@מD-zjyt.o޼Ĉe2 ^o[isʄ^#O5YڿjױKÙ-ÍfTX|9)zI wW{u * 4:~~~"W\?SKuaٌYQY!TS^ZNyq .sE~Ga>VYGGG8@Nh o}1~:88׷/36jb)`2\W;uٱcԾ#x'ug" j|QCT lY6>ܮh"P^VN9{]2聝WKV?%Ks ڵ[Ъ z'*teڴi'Il3C5|NrhH̸,.ݬ}msjҧS,gٽ:W:6&=Cj.P9s&JyiҺx؊DIXB Uz1L3U1Aɕhh/zдi$zltL5Xo$9!飐z .K/Ɍ3$5UWU_L_)Shwc= U?yf/b{-ֱA|yh;IN<0A6>/; 4RW\\̚5K3ŦI`ttWN.iyCpq+o{}d𵼋⯕cŹjdKAe׵N;Roz{N:iwv" w쨷^V/RoϨ>5}uK~5$<\ q|9纷ɥ[(yY9cxA#_D8z<2sꯕgUl<;4^{_'$+3ThR v=) I¤{8Fi)Q3NR AͳiJ:wR '1:M)ث@riҦDygFJg1q7,䁃PRVƀQ L@ًwbܕ](xr1%WJ,+GRafaY3 ,̱˧l.TӲMk:CenB]QTVV j˩c4u=#sכ[˰slo%C& g)33qIȚj- } /ԕ bs\+gq ) KP$u~gW̰[熍(ݺI JŃAXs{*p:/Ѣe+y`MV\(/gBru'ʨtx Q++#g6θk\SÆ&%ntO @3 v[g Sy~r4FN|XMeyeťAhּ͚5ˮ A*c(~' yI7CF+L}@f@֚KmN$kmwvj!zHw[}s yڊgpd ()5srX+3T‡J t#%^2|h:5B7Oė7r,[L+m<0Ak.E$(MV SW_lL^릻Jz{wJ'Wkf-lB9#a}w AQG+PVM|{usȑiq \0`D${WD6 6ZFGGvZt\?+3f +Ve 6,kfnG!aՁ>r@ R=S`yQ+8_oJt 8A@10O`nwhW_/<sf8zSVRܔ:gV;ТuKvlͺ^'!f>򖥥VOUGEEɪUd#[wp\rkrTVq…ZO;A15/]ҹtr;^([lW}5*C2CדjJӱNocڢ"e/܁q_)د9B'X,Zގ7٢Z̛Y=V5hv** |bاIIyևA?qSQtCzt;0 ]n%]ZPRtZqe[\o}Ǐ'++}iݕbpi*o'\OHڴU{?lϟNOLcԓ3qmv>V>֑!y>*هraeZ%rD#nCw?B$54p?_sbxL-n_U2}$8%B޺ 7 #)F97nO!{)|.UGZd-,J0`^^g`M/B{7w5~b&V^vɴ;Fߺ'f[RF`Μ-Hȑ j7(6]|#e_ N/9Ňp?YgZ3fٙmZ$sad.,Nn6ZQ ~ >-xzX]yegfi~ĵ*>,YjoIԾ?^`?OcgkzLzL˕l%g`MI uIQ\gVҮ]tLІ} {J wjC$<'3DUF75|zlޫO/nacJF{KqsjGk?#Mb%sxM^[Y /t@g uX y /;NcZ5qsnP4y/+.Vn?/z׿B/ol.r~F=y>Þiܹڬf/:Rwqo>y/3ּ9mS!dzXZo_L'?z+32tuDFB{ɣoc`8MVY&ቋclBqt`ʕ_S3mFv_1"bv?}W߼=V^zXk˱@+SN>ON߇Vm-)bF-}U>X* @lذC_%==и:e9bTDv8Fwr2xP.vT%<7Wu0 ^A _?d1wL!d@'oOL,XSõxC m|TCA5C9+ K\*:RQ../3@TxFJj_]?G$_X5F r$~J/4`Z.%{Ydt%@șZGQ&{]` 0E .hu~S&*?TL*L>ϚYu/?CVW0z &/Yú՝o'=zNa\D.RP|ioݗWDƀq9wO WN-l{rce@9n*U%Fxo~|e!DI9THK Va|58>T:ҁvţѲnrՍfO}QywFLf gKϲWg]ț O:pIkGwf:aݵ(6dnߓO+\=zܣS{Pt"N1^4oݒWYt'82'e뎔{SYQ aM;҂,ḅͅ,z! gQ= 5Fg=zH(V @{dM zgzL]RYM-&9h EUoT}l-+tRM8dp^Z@2 oPY:\?܇reuXoe uA{Wސ 2yj 3gJb!sIQNq:GF,mE$V+^ W?'Mp td/!=&OW()/+G>XT% ›st;a~Q4oj1 )me%e:f_R^!*֨X79˟fbBљt#,(/gżWշpMKHg,%3NMuӶ۝jh٦}]<w.:gl}@4d[w?Y1`yGZiUq=+7GyJZݤx]Ųam_?.Փڃ( kv@6{OTO\x6j59֘5`pt%ժo=gQVD;Ɨ`C`>zcA{WcRyełFw [`Pėr.Sů,/r?>^JGjۢ<~z]?]l*Ga%zeRW;gyNE q-VvM>J2: ZM3oi D }=l[Ys'3_|A[3Ϝ_QDذaXhѵ+[gO6,! Y$*;go{eV.ԕn~|jD62cX[y߇AZ'mʘy+g/1qRuͿVSNT2a2dey2hM͒~qke-i[ԧUUCj_1HBrsGAO8$2:,13_T!8z*ftLeE[+ऻ?8[69jjߴŭ\<} 'N#BĈ4JJ1on/ȜO>ᮻ{vz 7=l#u"ajo#G~ޜlzYy&LСC8qlFU2\ ?(]A%H+߾KMٲM8((ןx1gCG'9SL|<Œ'p=؇1"ġCfk[ѳgOrNc5JqA"SrfݡGz0Q&#! R~%GD`Mwx8I/gȴ%ZqPWCDZϞ=[r!)))Mo :mz5*+i. 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B&`h|\9<置I5Scyxn#C`T6wUc]ꢥ)E(R8QQRtJTcF7wSnc˼~Y,sܸcwͽA a Dǐ8x㇎8qg4- rykZUT+jfz=k[bz<ӈzXk[9bOC[ϚAnUAAȩkk\ŞadL,dH @<`p"<@X\d\= c%KB{vj r.6^eKY< e{V,vNfnL!M[ֽk='t_3US- ,,6'†`D sЄ!cN0ơJBR,-[,b0=s=b؃N8Ö=kֽ{=k-ZP\5t!33-kes^=K4MZɃ5[A+wvkwva6~neNdeB"*6l ̩̬ܽ]ffVfeUT զ jja25AT 6r%.[1c ) &4O<,&0zy<=YhA(YaÆ0ӌ,<1Zq0H00 YD,đ @h,Î, JXK0Ba ܭͭ܍fo/svf33s1!f$20D!@+=zZr 8VlaYU{js3wj2cq"<`\xhHHHHHHH\d\d.2,2.2 *@`"D(h`<V-(C4纃b DhjF hU1R)QRxj#C`.+#w˻ʚ 얹paifadN800&q$"Dnj,.28၁ 4Ay ,%4{fs * &SZ֭ٗy7wwɥyP٘Bf_ݨL5oznh {)B4M85U5 6 [k!'٧U3U[Pl& 9w9EWq\b#n*nf{Ġ0|ڪݨl ңnUpP*2sffvjfjf`lM521+Kias L44#ǹk"alUڮ7^Tn7s72Fvv`K-ֹrAr9or9kcK{i{\ 㦦s|Z9;wwy4 k4Ì,49kfZ`^T,6@ ;7w{U0sֵ&YYfyAsM6jƥ Tc̬DlnFb:z!==B3uZ{ܷ{{ǹ{C!@Hs0[[slbO{1' ׹o[ĥBsc1 [yY)J 0aPyƭ=JR!'iD4icn{^.ffa5SPݫ;^^̷vV^]s+cWY ک`{孌K޵a{ZҔ-b9rĠO5`DQK ,x%[qs-Cy[{[ *jjRblLֵK҄9ؔ[UU0ٙKm卍FscwfefmL& \&[6a/ZR1bPNAH,ǎ8H &t2 .qgU NFDi 4)6P%}N4'yYD§EP&e+ﾳ<*4:'UD .REƌaAh fa*'Ҵg44qAp@ ˎQD ,x й]otYaG<"@ (Ӯ.24 "xNi]pHhê26n&L4RNPQ8A   HU XTF뭟HpDb#& <4.xqqWҾ a HX mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???bZ$=? @@ 6@hP? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition/PNG  IHDRc IDATxw?{+W*Q1%{H4fQDe*"Ղ$ *J),"u-1X(r?ޙ-.K><̙sfμ眷2 dp"C< d22ēAO)#C< d́'~[x22]2ēTU-C<(U%C<(2ēAJRpf'e%S"J# ~!H'9 0(EE{(_FJ6)Q_x2ARdpcmeIOPBJVFT%o9A9*8ŝy }gp#WW5O^~TZgA8uHΗvQfEiA|"q;c})il߻ CZ=p Ǯ_9۬,0!G>u ۳kqgJzNKKyӦ:G 2: ;srG83;N}Q00j8܄{2pK+*+c\.OuG(oRzu>9zm<!ݮṐ#\)4ԕyNTd\ܭمs 1VQ?b^ئ?;4~q( S Prhy- vEיfJ87AV,x]+MЙ.dË\Gb /_aynm>iru]<7ck ]W۔n :D_>)*2ēj7mw~vrwũ?$l۽}v m'`J>NpyƢtԫiʜS8a Y`'jW <{OYݹ>#Y4ҧ9` XyXTyπu~` JT́&45&Jugb'Ŵ!Ԏ}2ÑA=%ټ Ԍ(8(T]5(mncs%0m/@{0br%0*ϩj`mU*+}oǀ;Ǎ+ۅ;@T_ }5ü9,܈d NWrRzC͇N*'/ 9+;!>xNʊ(WJe_@-(%Z<}QϺ u8j 2q)8*K4 UKTLDjl:{(o@|p<#PXpTR. &5#5^S{(:+6ۻɾhḾB$۴?9Eh _ݻP!h H3S5>/#0[Bb *=f:TIC܍FI!Û>oȑl[[<"gmC~[ u5ʋNh7?{-:]m͡cWT*c7>bhef[ #E3Ng)(k,w7t̟^5=hJPŨȻXDă{Q-a{x67?+ <(@۹ h;{IcйKQBzLZ#@|T5F y5x_W68ǥ5U^iWc$GHrQ$6B 3%:h z;; ^E =˘Enxu> |ZL7+\KTi*ݎ=KP<ۨat^`Wa +mMDGI-=a6/vկRץ)!Naq''̰u^ު1 <8s?\ j<]^-P V~[~]aӳ[оL< #8JKai<JdV;е, _5G?O,ׯ쾉G|Qهp6hotBr:~:o?:3 LhgqAZ>aBb0xMcѨc#|Z.H y<`ܣ4C@T+Y䟀1jees`La,>r$ xQ}ثRKpK{R^#\7N@{[O@M u~]rNkxɉZV ț#5Bm?0ILrX9@h{a9\ A~@ו +9f]5 gv<͕(#;7]| R{ic !) >ƿ`cn" ?: k{&H/y5>tt |W ^ *o+/ Trj)~Q2I6{ 5_BQ|ٺo?@VZT=00 nYXl.G;̎ [䇥Yҏ&WP>q+[n<;ӥbUq-ը5[eJh8qL ~4d؅~d*2R-6g`N6AM`b!PYj;Pz0G!;ۥu܊`ƍ0 n ;z#<4Ƽs*a`7:ڋyzG' d4 ~eժ| Pc;/'P@*0FTgI0fl≌|سNij5ru6}q_/~tY4֦ DtW=&`by`ZhLa?[֭OE D@sau/,@z4_!n$NX*b# $>UG3 %hCnCS7J)L`~ցz%02%T^^ζw4Ue.1j4[C[gMKxҕ31RTJt:,D/hgN@-CQ㰴=puQ^(GEy\j|6j3ڽjǡJBGqsFDzI]F0'58J<ٶBL⩍#zL=@? u`r q:(V3  %j|e-Gnw2qD9Y2`Um՛ZCdb (oa&ᐥ6DApc1X^GWp '&A_.N$ܥv>1 a? "Z5l?_Qd}zO1}Q>+6apݬ]V ?0"l)s1`I!&Ø |1HsiABOPW1 +Ј1%(56A^(KP 5sۘ&:c&F['Ψ4q1(^o\W ,Wߝ]j46"?PWK)U׳!+ b~ӱ݉**bJfiDRn/&bF\ߏG9YKg䶅g30zQuiB4B_#7ٸweW;E!OĞOVҫhrXBqxb>pt(< ?>땅s֋q(O>ef`st\U rӆCRe"lzn6:GU~(ÕGZG?Pӊ1rTx \k\lkn77gۄH=CϜ~t"e ڔge>p7ezaKM25*m[&QMD9!4v6|&8^.>@'ጡT"xC 'iYPBc\|w"c1]DCi*Sl  aN^*qWTpVy#ƕ 12&u,BU/D:7.61Ģ-u Gsy`NbjAti3Gz~a8W&h. _niMb 6PrQcQ qXL;SC,?_N deK/wqdXÄ|%79SPQWApA}t)^#<>aeVc/mP݌o[5`h0$zPa.~om1p'QK8o!*iЪDAqFA;̗\Р O*`WE,c~n? ߙ)+WA']i>~LYֈuݔi* ?1 >,(à?JV/ nB&C7|Ƅ8m|(0ެ%ܷU5Q_䓫_tx4.nTg)nHyHL@*ʏeBs`Z}S{̼.½$nV@N ]:8o][֙g&f%0q)Lg`^L O. C},nj27MCzxf`:ι`QЀJ^D[#}J4#d <+`kf -.8P78#)6|hEWrLpN19 +73v.u߾c( @گNc} fYTdzeg?Fp$9jDڵlݼ~Xt!@)Ĩ=!Sha0 iaNAEG$D|:ֆλ큓'fczAMZ4P;d}#ևXE8΃-cDl`3EJ*o v9]6ƚI'MJ+5AoQp TbXqUY߀Xeb7қbDstnesty%#|8#Egn+P" \l-`–-0+/k=ϪN~R|/`TUxȃ~a+XlDCf,,FE.+\G8:_.Nq xB=ΩRt:4&vxё8Z7 vg+TmA} Nh,3Wc?*9eb= *F qĠ1(&eC6y7*k,I>Yxw*t tQ?yIDAT%;5BQgԋ!v)@'Qft&$tIh '{- j\,T0JUe[E9{ൈ_`'~CTvJXֆ)O+c^_j3@"ʐ pggc\aHA=P壅(E 2׋hޤOgh Ub8V P.):_a%_hCs}Mj9#ϷF x:d@!:q3YcǡgߠS5r,t2a ?Tf}+k(nGL<9*ŶLgc!:}x x}Q޽,.aOdeQoe@t<BQ4hqjNސ{#@+W(}F]d*̿_g:tb"[ޤoCۉBٌs񎁌sqO u0c<&dD`$bo%. oᤒ{s< W߬ vpLƷT!+AaԃQsU[c A+QJ ɑx*4L$yTp8< <4lϣ[LmChW1s+k[C~pH8ek:Ҋ*84jRB.ia2u dhr,Ѭ6 0x|_#eRCEq˝w708a\)32ꥥbbsRTY [[_͟Ͽ eHmQ{0 ^X JymhIx- )+ΧT<e4"׊#x@M:3͛*5ZT;vVu5-rp ߛ:bxT $+~8W!ڃlAl[Enԝ512:f+(uyn]Ǒt QvjÚA2AԷ=2CbSP;n)/'υ l+1zBS -o6b4] 5ܮ`gt7ff ;odhޠG$`]K/l(bǃ'|Lae#  +* A׀v>&=\MӼ{L*0 kO bo^N.o"LxI2~4:+[}㨝y@}}d]':ash5"p&ꮼ=/G儑*KuEuA2Fm(ėp<'QAPyRxfl<m M8ag2DᰯƅAN)ce {֕Nk7Yvb0'Yv<ʙ)_n]["6{Kyi) sr0Pcr$;QOD{n7@rKKٴm'Z">_@ g71w1$j; f-{Y=p|I  -;{`"#kGsӅO 8RhN|T \%.7$ůG%D',,hb^8c^n}(Ij5SʗH+QI1DZ}3aNkPP/Q-4}A}F58jg(=4b=/F **KJ8Imse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9j%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN)K   ||      `'`hqa! B=l\&IwqR.xl )QRF(E((loFƆƣQٙ^+f&*n7ylln"ba* ETJ)JTnԥ)QRQQ()JEWEWTc{%*1r)yww[Uݭ~PP 3732Dt @$Y{4xP檶Sga~SWQQĢTqJ)JTb(j7yP{<Ȑ -iBZֶ%u50!SX&+6 ̻ͪۻܻڹښܪ! B&`h|\9<置I5Scyxn#C`T6wUc]ꢥ)E(R8QQRtJTcF7wSnc˼~Y,sܸcwͽA a Dǐ8x㇎8qg4- rykZUT+jfz=k[bz<ӈzXk[9bOC[ϚAnUAAȩkk\ŞadL,dH @<`p"<@X\d\= c%KB{vj r.6^eKY< e{V,vNfnL!M[ֽk='t_3US- ,,6'†`D sЄ!cN0ơJBR,-[,b0=s=b؃N8Ö=kֽ{=k-ZP\5t!33-kes^=K4MZɃ5[A+wvkwva6~neNdeB"*6l ̩̬ܽ]ffVfeUT զ jja25AT 6r%.[1c ) &4O<,&0zy<=YhA(YaÆ0ӌ,<1Zq0H00 YD,đ @h,Î, JXK0Ba ܭͭ܍fo/svf33s1!f$20D!@+=zZr 8VlaYU{js3wj2cq"<`\xhHHHHHHH\d\d.2,2.2 *@`"D(h`<V-(C4纃b DhjF hU1R)QRxj#C`.+#w˻ʚ 얹paifadN800&q$"Dnj,.28၁ 4Ay ,%4{fs * &SZ֭ٗy7wwɥyP٘Bf_ݨL5oznh {)B4M85U5 6 [k!'٧U3U[Pl& 9w9EWq\b#n*nf{Ġ0|ڪݨl ңnUpP*2sffvjfjf`lM521+Kias L44#ǹk"alUڮ7^Tn7s72Fvv`K-ֹrAr9or9kcK{i{\ 㦦s|Z9;wwy4 k4Ì,49kfZ`^T,6@ ;7w{U0sֵ&YYfyAsM6jƥ Tc̬DlnFb:z!==B3uZ{ܷ{{ǹ{C!@Hs0[[slbO{1' ׹o[ĥBsc1 [yY)J 0aPyƭ=JR!'iD4icn{^.ffa5SPݫ;^^̷vV^]s+cWY ک`{孌K޵a{ZҔ-b9rĠO5`DQK ,x%[qs-Cy[{[ *jjRblLֵK҄9ؔ[UU0ٙKm卍FscwfefmL& \&[6a/ZR1bPNAH,ǎ8H p0&(8tPE *`‡ϟ.@dSeGH : h*0x(>@`HTSC x&qQ "D@a# YAq`ɳgG>\ؙӣ!pS&&*42Hpɟ&>:6SX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??+1QY9AfffL?p}2+3EDNAfff333?p}4?yq$?? yP@4@ <@?W?W?W??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1@PNG  IHDRc IDATxy|[ՙjI=$@HH-PZJei.Ӗi;3eJ[PB @Fq;vĶdY=?ՕU$O^dsgU׮t#¯_Ndx8\lϝ!e9%$?UQEAn=L4"x[Rk+63_7%cI0jTTUESUTUEa=[ŃM+?ˑ jM! g|݉np7tZ)/j(@l&Ǖ"eMdry78z*B39YaBGMɽZlZ90 q]8YV]gnzp8z1l|y=(h  OS&?$鵨!!rR3bu@`!tNվtl>X.t=B㴺ue~YꚎr;j8ȹ:Q! 4TTEEQu"0sf7tCGyBa?$d2:xmk%0hhuJ.ٸ h2cckc+4Nk^5u{ueICs5msã]z'pӕxGFdʒRxP$@(g=kλ<23973ħE`0 ^/+Rsp]~Z=>5gޗʴ 07劌 j`ͣz/ˁl`AN?Ia݅ÞE(maAͫn/gϝxϝB}$A.ZOBȘhp4@jc|-0l³‚w8~λtG()УtZy}3:Itd** gC#/1çSQ:=mȘ3'^JITU;~3. #a]»»)3gWf8~moY6Zl 0}ogHٙ;>w" q9r=Ea$\v쀯}-sWƦ9:oyM[鳇8ts iW jz⌌D2t]gxgCoN#j6::[il= j2keMkk uMGۜd9sq:T] )nˌ  ɐsQ~,3&z6, xh4p~7Gαy_C8``f}I6B?Τ@QSC yo ltM+?DZڝDpPoK- Mo=WH-m8lN6'fcՂ[xPP'΀fgɬ ITa"L*1 9tb;H;Yqɍ9;ID}s5m|<V>a?b6S 1 lEQذ3iN} =a#0͙|9~76;_3mYfa xű], bBiILnLntASS# Ⱥ .A/ሟN *UEUYgz(Fߍ_Y1P9RKj!8XVI&xݞB!JW5  vy C4qTE#,|1GrA^рzH*0}2ɡo<R3ϧtBvVHqQdO 3sd2l3Q!$MG0JQTTE5yaهRAEh$]&xet rWp[f.FF17%#H9}WY>7|GŔ#\$ibJ.! |A/˱S!/]#)[Qh$.g)-Ѝ(m)ts7a*( T"Amc P7j6Bw0 kS/=8='Ϫ:H_?ؑͅjBu|Y41R ]D1 SIǶw4R_(T1}wZfNLL{Kg hw.^ϝ0r 1jTl8#-' u?^Va"0 iݪ_WnO[/ךr3la,̘< w I۹[8qzlmmf߱8@kNVY+LS`G8nsRZTEQ^no3Fj)c;ɣ6$+1ϵ% q_ٺ/JrIE.5dg+;VVz D C xp9sX4c=N x*ʫ`q@;a5q|`k׮`ڴi\ѣG3g^y˙=[:ZWΐihvaF^Ng2j6.ţBpww[1`&⏥;I`3ॗ^}T׬YáCXzuV`~k+Y߂aY0 4eEU}?o^y<8̛z%1ϯI/L~~r?rSt׊>(DA1۝ =p|dxxj;wǫ %[<&}wC,NN5 ,}πA'Kטzrkax1>O_&&x1\N}dA M e om*=xC z&!t+A~ g-mNTEvcc1g?'?}rvY+TVLd+Q%UdZp+iر#m P$ "AV^π? *UQ2&sWοj3֊/<ܴ};|ݻ> ׁpΝhl{5u{ &HK0mz^|ڿ&H9$+gy 6pduEQxIǶl9\d  e_UWB{w =BHBN{r$ Gd'tj$nX2mbfN41.]ʫʌ 5Z1ģk,Dv{{M-~ x1#A2ֵ;TEUet`.0 =ka- EÝAܝ-}zJ2p[oۤu ;ٵkԥ_nڴiL: -ŲeOdk| uO{!^[fF! wzH) Ⱥڿ/s:ĭ?My[0q*Y >} z GЍq9x[(-M{nsⰻ*0=ثiA/^;6tns[no-nꁄiJMY X3KYv-_Uk!o ~bcp7.c2aeZbFBkʼb rAG:[k.?B0o'1a93/^U𽃉;M/83?|8L<%,{َ\B HPď]elVY6q(C/3j0s›p9&PPغG/[F(V nm!cm:c2򲼿͛Dt!`Z}^v|Όia?-Q< 0%NԈEx;[9x Q) J'# @y|$!ca%yf]e4 ` P8txUβL!++ H=y f|'`ٲeҧ9ZZԩd@D(jbuutE7t0pPO8L)lP'vֲK50 4͎ٸa͗yYʊF1@!&knV"Wd MQ]=v/"珧w/ @zՍMoﭷO1KMS| ߏ~#򸭟51f>ˉ=!!)VBSߔ^ozб,r7WK;ͅf#W|?L +d)zΦu墏ǃ%Y~{9mGy XN1#TCz^@ZC|v-V/e0.?v`DBصd9q9).qa C఻0 _q._xkPļMGQPx:۰du/ގ^=_ID̝;_B6쩐܋Ad[OŞx;t=??z(+V`1ہIM6%r!zfTvF|NnX/UU)U|8$27Iq~JçwnJ2}|+|Ο~bs7C;wӧ=/ ƍ" X?A(ch%`C[bvesEQTBiW\c A1˥Ux˖-կ~%I}d<|c|z}/M_yvH/c˖-{l1w\MuIxx}-]w9︧N5mk#WZXIa~YE#qEuUvfg\,*JǠv:m,\6Vq%8GN/wѢEnwe(--e_8Kw(0ǎ㴵qQjjjhoo_dݺuBjTb6MwsN^}'>}lܸg}6#c 5,9w=NG&f^_HW<3!W6Ba_Ĺ OIDATjfўi:Ʊ;kشiSFLWt[[]wR] #i<#z9l 9dg',/s@6-f#[zG1u+{Sf&IäÞG9~|_и1vF(%Gͮ-P8?XX ]EQqX;Og %-P}P'HӒ+.4hȷ'L2nsqz+Baٶ Yi1_Wy "UR 7̾k+ Xv"`RH4d à3.6F4ܪACipа`$9̝rf#5oXUUCQU6lXZo@QN=ԭ[] MԸw~e=N.p)Yr/O_ݥD!0rp gYr4z @Smq5SMz9^߹VrLEYLZmUZWd7R08SX_WǪh0o96Kgo0nFӨq7a3j^y hffs-zʉDæo 1<*3X沫UW RɏGds=?5dUUJ[ChR(h3/*,MʎuͺS ;8X:Y+դ( z)} CGT|]R1dpqO2rv\iI]ðQJ ;m#46]/Ò~~Z@rDI.FeC$-fcV>O,oy&-,YKV ivE%/=*[neŊ)!<|ǀX>XN ΂I9p8p9qڳq9ۥia¦+?7 J *iuSY1&ceSEeW GCz+b)A ,IkF~~>?83g/g)ЀvVhYQHP[GAl)6'Upފ^G괻1ZvF_Eӻ,o@6{lFiPVVƕmDz- ӛ h#4x}m{Q^<_P#ek(("˙gYH~zBSeOΞ?=aXXs]h+y*&a>Κ%HzxƌΉ3Nͼ=Kbz?ezLG%gQPPɓ'9~]8axYgپ};= }J* sã<q$@3~|lS^橆;:fBEk;;I$?H4(B6n=U@}!YL .Vϛߏ[ D1["\fT@oMpu= n^{!gq5o3L۱uMG6Gjj-C1nU{یqnnN·X)6݇e;̓y̓O9so%ț`+/9;\dFϭU]Z$51 PKp$` E_2W.ͪhqsUQygs2#3[lns4ar":LӞӑm"zp4hdt# ?PxUՒNhiczHE+OH4D8*{v-UzLioo矧 2'ѨI]=Ea4 N{b I ?@}K50vH&}[92)k{:Kn$ìee,Y[l1LuVǜ\%Q#iwcr梩6Z=g[\ H< 6EQx'v)b̽XI9*j͙ylv)-0!mN CooGyz׀O >JVhЭ[*`N is"} Ea齞$fpwK[XJh($.dg$8kpDg=}.3L .G6v݈EEQ8"qz3!>v\IaIXqLZxnNyzvnIh 0Ekp?m-Y !hh`;o}(ʱ&f>$:Gա}ȣEOӼdp^ #݈gMl1_3"NJۗW.inl?1P;(-C7"8~ۀ|-VO#(-x\Nٺ\9 (%Bh,ҝ}QkŖCid ƭ,HnvߪpC=p""HƎ0 AoD41'Vt1V)0 >q:\7SP&W}SZV̙j^Hx+fy`'֭Sohj=m(+Й?ax45kGڥwvif:˗`b9*ӲJUv`= @Q8P)yb6 -}$O|;T"pdžԵ.?uw;r"Nm/_!)EGtC.;((L<^]^}W_Fi\y9S C׫J݆@hI"r L ͉0tFvO#o\Cd EQR"DY( C٭?J•eQiWw_:iPY>C&=Bsp<5"Fr q:sp؜z_0uEz#h-ə tk{xk-TOdŷ;LM$q:,Yofz-sGI Kt F7ʔT\L~j`1TA',@dc/[Œ ;%҅.tNrBpO{No D:%$ƎCII1Y.p(l@U>rǤ1 :n]^`U-Tr]FVLf߱B ZIwre3bÈDvv;6=!D>iv^:Aٖ>8ꒄ@Bty4(NmlQ]Qb(DEQݰ! Df4Z6Lxpb9tkj?Ԝy_=LT;tfِb1D׮IVIZ0D"a")ylVkxle! x'c`lLTU#dڼM45< t1!Xz-҆dIHvO i#0ۡ64-閈XC$b=FڈDBT= AI6-MO3 ѵVm]t&bhUx5kұ%QH V8OU*&ˣW8pP:|qy,ӭcK4ib8RlD3"̾c[k3r9r $ ["6a.f˸QUM! ]߮UB:d'M"JIdU?Ё/IsZsY/4Vβ[,0TObBf^vāǒ6vl{A=0 EC@QaiñŋIY&qSHxZ= ((y  yf} B ECJbPdŲ ˖`d:þ7=q%+6(( Y\ANTi&Ξax,PYE_s2ZO%3R Z0*gZ= :7WdFTĦinM*xQqk)o#Ac"O[T ]Sw\hsugQs'xX0j[%6 ϥ1]W.f]ZԛYW/#Mns9ᓽPFBO>KZRgS.5sqq Ų/E}1ZHI=ڕh̒VJGop-2uL8>'μ?Az\Sq$jq].y摗' ~MV屡Fp5و_?ƸoXNY9degM$&B*  7EUǓ^"@[w!2ֆib (*jfRym?7HBaȀuaCXffzjҹC>ەOSi**׮x矄 2>K%60w."7[64q<OKHnq͗Xac{K=*##GY+mO$FM"uVXa,! 7z DCo69t00[_z7i6%EňcDEG<`r9sq9sp9sK4bv_G aIP$`Y|C589*]fI~!_w+IENDB`move=1000;blend=1000;3EDNB1hK| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ ,Bf *H$JI"""""""IUI$U$$DDDDDD$ URUUR %T"DDD! UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUUUUUUUUUUUUUUUUUUUQUUUUUUUU_UUTUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUDUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BJV#֡(Z֡J**"֡jZԏBZ&ITP-jHREJQR*RZUWZ꺨BZ/BPR?F UԟZPTi?W_WRVZ'j֖ZBI H$ $I H$ $$$A$I$IA$I'  W WfW#UUTUUUUUUUUUUUUUURIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUAJX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???sļs$??P@@0@+&@? M? M? M??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2r'PNG  IHDRc IDATxy|=r#\A1܇) X ת~om_>QzUEp 533;KBnvcg>pՄ@^/ $RHEC7t ]G7 CGu}>S8xd'B8T'1nu gW)Gٛ33ÅttJ#ŕ?PIY!B yx}^^^|$*=e]i:t\TE((BW=Y&$_Qp9]nSv`dPFϱY:^Q+ 33mܙB؏`fO*&$UuGX/ σhS~_zdXMLJ5:SIO!XB/~!d„Nx;~-aY!7~ h.duv9?MÅ˙ә@o" <"PT]#ϦcSHivzPRAPXc 400iU h~a`H| ],q*]}o@(VKKG"4Yb'aH@**+Al>N|p^!3u5֣o8.ڨfpPmQEUP4`኷q;Ӑlqye4eutUmeufPl=z!7}^EŅ(jN@5 hO> |!pnk.ܪ`n۷Q|`L5g7;o B7sN?4SތihЭ! <U͛s09Yy8Tg{K M`>]Qu :nh躆ahYmzsƈ} sqCJi,=`wk`]øV_*_WiVHi9h]7~+@7MV,iYևifm ~ =+WN %UE߭51b~يm[ˆrH)}PT\X_a褧fe6UAH{BiJUnϷ'),OU#, ~G<:ʬP泟7 4bR `>PmCqnQ4kjnt9&D'νO~Hһ6km GjjWs'LIh̘u L4Mi ̯d7R&X ~NVE7 o4T"et χu||mGi(qTs 4t$`k K>O+NbmBCU(8rr|+ WSU_47I9?n ۅCN?w()k<5pr{ڸ_y>~ UU͠ Ceד&hU+״qw?2%ܸ\n@0g= ׉4DăimOH@4k;cm hO-$R>F#hO4tuՄ†,! t hѪsK]iO-4xB!N¤"e6_nd&Ԋ>,aܸ_WK7{Sɲ||I/tm4 գ!(.z`ͱWlQ ,I;w.n+WFZX_(3耴j(j]709/8UNkxWҥKk-{!77\JI~du֝+qU Jxđ]S}x5I&1o^=yf6n܈dѢE3McOQHi(M\s $##uֱb *ݛaÆ*RJ~$ԶiO?~<^9IKKoNM-M3zbÆhNmLe*Bm6-nt?s&pZ'Zg wۢH@gp4䑷YkBLA$es;'{=i%px -؈aӈ @c@ڹ+W<N>OxuBhyўn2ZMCֵkM^mڡu705J3PCG3xX;ҘwK@g͖I#<}]ƅf3T+p1X"?!26o, vیGv*' O6m(2B!p`ZNB?d&RJ}W26MWa RJVn"f°% ͳہ:}&L)x^Z|(qOۿ^4B7Zdܻ䱗o*Q-l8a&]mw_x׵3N9Lq B13)VbtCgɺ'N>!'jH;!c=ƝwF~_B*@7"R@2bD(ŒwBRMBpt iN~?VN%#~ + ZXs O3| S] 8aH+" 5<@p˴’[,\VsMF '?x>^gɎ߮{Oby?Z?E(ˢf\ bDUbִF> \YкmZtDu$r 9sDl>|xRCg"$=lS,ɂEV¨1Rߗ 0tá85tʉ`P ?#W=ȟ'rssYt)/ߣ>uWhbofxyp,z,ڵd4ּ:ˆmΤS~_;7{V-U9xwJJRRmBЯvMWadbH5| ő}Pdgѯ kPAWw7#sBga:'&\wSV~̴EY5v8m/l/G"=Pݡ:QDro)4Rjs Z!r2h> 는.g $g%صKrEo@>T]z|Tzr,/⽯VF#^]km1괧ƓAYE 6-:oe+4B^x|DQvѥK }zjB8q*LojPJzJ6.g*`Na,#踔Af=60f̘ZMxΡAsGSVQ\%7m7vH+UpFIBFZ6S#X#dY+V_|a6]>h>NS_|^x?aг`BӶm {TV¶m0>בl+ CLEx<Ǩp3cqp= [FCY1yJtCǡ&[oU /RTTċ/}2x(n"ę"x|~uث~[ӿf޼y@8o9nWjѭ_?(YW5DE"Y+SUFNh~4=@@Uyae<u]L4 /֭[G?Tz(] }ԫ̛7y1~x֭[M|c4uW*hەNncXϝDvf+3[|Ұ߫Ւ%KP9so>tZ8fdί;ΚSTTe} [AAn=\:l՗<?TeiݍQR7B0o_~G2m4@0oѳƬK2|=Gc"I!}&Ӷe[gn땤饧~^~<<{9^{5tB<Qr0qnvΗ$b~VQZr񦨸Bt ͟5DbaXCdכ PGD s9̚5!u.hú-kn? RT\ȹ/htxFlU^(*HCMއnjgs{As.FZ~ޝPģY)& ^ gt|G_x~nH0'c'naZr%;-[N^N>϶]k=0p:'ػhIp{KۊTƍq:m۶{7Ҽ0KGE7RGj<]7Ѫy>>JoU@Jۗfk:t}/ 5Ffʟd+NDm1 ϱ0hĐF??dzqՄ?j+*.٦e6.ĸU<4`𛘿( 1ܬHiPQy„& 0tΪC{Va(ڌI _I@*\3hWN8|y.aɺeApfNHɗ+ΊUn>nW.g*\vl> L⟸-E^:V\֭[z K!Yx^Okhw!Zp=Yo=6dfHAa5!%! (8T'.G .]ѳ;+H2<#lݱJg҈_$~q5us/-IDAT,ܐ®s̘1у'xёVnG^n>\Gu4HʤCu"P$w (jZՉCq( @U(B 3244=@?Ԝ5/\<@t? `w3S( #0U9i۲)tǁH$ ]K &0yU4*I6 TAbޞhہGvUIҫ`cd*{hDJIN<.p߬gj_; /;3{2N v &V͈?%=5˼¦aCQ(FM 6xzD6QBTEv~:lsæEEȹZ#Tσ4jqqN=~ܻLpN{$n5!h2_ 0Bsu=E: OQ>/dh+.sύ}P|؞ݮ{]j CqCl߳ҳ`8)H` WOĜPHMpͪw|`myjWZ kgǞ @ieT6,bNI6S42K8 ֡Y1 9τf"B@d1ztQGi+`9ٹo#i)3;aFԭXNEVfKF• m rj Cy]hO!"ruخ|}Zڴ8CQTg%5%Lu5.IFдjZi|ַS~iO++N DN{ u ͳ%)YmL!5\:wO~GI4oQ̨yHӺ#e;PcmY@nVZdEj28m-0tsuSsUvtHsg'=5 )!8^Qž }"R~JKO;Vxt?ؙCGvq!V.AQ4]WP9}勏}$#-D'_mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUꪪUQUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| B*֢U_UW/EQP/֢*UGPQIjG֡HZZ֪?_֖Z'j֖ZUWZ*R? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ WW #URUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???lIAl$??M@?5@?g?g?g??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3 PNG  IHDRcIDATxyU03lA5hP% *aE1qxL9^1ќ\5I^kh\"l; ,kU?zfz隞_xz>.@η.Țx dMA< YSO)@S k )5Țx dMA< YSO)@S k )5Țx dMA< YSO)@S k qYoS\ h> 6E<6dd 8W)x o#\ @A qx\Oi qx\B|OϖWMgC-= q q/UK&oKܣ e>>ҥiz>8DaA˜ 7èQ0r$x<_POxQp` Pwޱ:NI <&g7nSO7$$bYN;Ma6]/1App0b`p!p*p ps>Aē%Q\̻(,e[9չz./W#fk}=ݹ ,sdi)p#I13]{Ν;ٽ{wHq0fIȈ(iҥy!yG4b ?>۶m{Jzn_~sLJ8z MӸy'dk.sg0[rxJ_|qcJR'Ecja %y~.2>j<GΑ+xҹа[@ 0XƲ:<󩮮fBJwi#G!0x6t &pmqmO OOwِضmX~}UV @b ?w\1iҤ S@QV:H^Ozi'o@E—I_s:Qz?^:)j[kXr%e˖V%eN?g G7[?ď~# |qK`9VX!֬Yӣ;>lޯgR :ujqǝ>~ 뮻G?ˊ+~=sz.0çs'y) 긼=I!tH^qƉ;S<f+ˊPPdO4o<_J\ǿG ^2D,NJ{.̙#."[nEySrzUU}ҤIde AW^[ٳ1b_%ٓ?j8 |9+V`,Z(}uֵzC=ѣgoW' I{..Yz ӧOgȐ!LG>)wy9_=/±rr0jHDKNcM|(S|E̹|Y˫|B$a[!lXLG//ς]u<~, I$ }$R,a23H[^]eyLX 7 #,9FvmY9珙)ub.n/:ꜚY2|B&CV JEQ-5_GEA=Ȳ$+|{ct$a;=  ː$2_b 9ꌼoS !I(^<Y=(/vlk¶q=%3|o|Qr8([-;i@o:SF!28ndV|b 6KIr5[޴ЩDՓ%Wk<ȚodmWNBL&eb Zz$.ܷ}]ϕ|N:=4ƃuya,۵;%:-r Q|4aIF@BfӮm3yHǪ?-R_˟aİsyLLaI DXVk83<ڤ=oq/u5\K;J $n fO1_O6)EaZ^DZEBBdYA<@Q?JwDTcg:T٩ش|vjb[N?JžM)u2?QHHLx e;Δ%FxЎ<.XG"I BXi;{xe`4#{smN #%,⺊nh@`zx}^^i*h=膆EAbjeC(+ *LUZ#!gѿlebXJ$,yj03Nk HJAxKURVҟ")i`Z:i` P)&:-+L_Ϻ# {Cڒ$G<~?bQj4ih-"/ <}O8g)%|sS.%cB82,+Ux!aɜiKIN/?wo+C:3.]x|ajhQpPĴ-:ebu4NQ(.* 2ÿ4UӀV]XiEXDb dbௐj[Iv*G3\7k,[4!٤`ϡ:uMBFܳ.qzX͌V5[)+@`*1-BKU jQ4=Ɓ-vnfm'ɲL:Z"X ׏:i=[0L$@ |^a`:njc{S)/ɷۮƞO[MnTUTc2h4>fIvr\Q~/YS0 }YgƥK(-C"D FcTץ_9lrW$xd$S\n;0t]Q< >L&qa!K2>O9s_+UIN :VvЦxx<(ǹUh9!aa&q9 4Mna~ Ygԗ-+ƲZKmÁ|f3# @]!UfK\WmܟPTu#e5f vM?*b|"ߙ(}.;_=%${Q9scB,W䣴4(&Yuynſs0 1,pyvV2h]U*GU8\õ7fK݈UCvK$d|#őN ±f|-EU CQ<̺V?[l% js0 4&dt9T S0M ]P'(OY '~`E-nkv׏</{xD+-ph(e(vp=uMUTb_'f >5tC'`۸a3u @V1Q Yx(J_7O@ͬ`OF{MjRSמWO\Y;$n mBUEu!()H 3u~$qHt MEZyno# Ij#Xpq=F\q/f=z%}=6($ƭHX X p۵'^Ϯx/M-8$? 啺%,Zt[,Vjl*d}!'|JCuDj0gOba$M\hL=q]%\OT Q ̉lnj=UIkWtKv6 EG)'w,hqȩUZeJ;{}fwFEith\?YvgOij}CuvJ YV=WjinqipyWi 41dI[lgg;eVH'{4x|Zy%Y KApB(rr[eYFr&xS|c0TUfIĔнN gM4ki(k N ,ͻHibi]tqnl9f$gT\&H(5/_<`-M:BFbZ"_1ߙh+ .'q ---R'^.JaeG4'i$(_4PvR?RR0z +G1N{=&n@G춟94XG Jxf#}5%\OyZ %u-Yp|"Z"mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUWꪪUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB *#R"T/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ W#UUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_X~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???pp$??@O@a4@hD@? ^Ƿ? ^Ƿ? ^Ƿ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4U$PNG  IHDRc IDATxyTՙ[4B5,\0_oNƉ$f^L5L&q2L21hbQqE܀@NCo{yKUu7ŽusNu9yγ/^=e6mbIeŌ3Ǐ'ѵRXvX' L->(%18o~)'=Ur#MfaR$q =%-l+I,Yѓ9ضT6k嬟{91Qnr.|",wBs)%m$vV "(@*ɮG9aK)-jrDzrg s]!XR[E 8]4_VuX6b ߌ-mꢧyф--ڪ6h4k.Ɩ6"/w6KHZq^]$SXЍbytF4<{ |ss-?kvgh3dPT-ohִa1} IӿqzjXUhdE.mId'Ay/>FZGCÒrl&V4L5C3i;blZ W5J̣kBBЭ9,9F%Q(D-jc5:K=NYFF8T@Ҋ#m_~VQNj(.v.G D8ѫeLjk2n>w-+❛4H,FIQQ3ż\vem?N-F$ϨaSфi;%jk ,8N◿%Wz+%%%c=ƦMqFRA8ʱIfJrte}2OQaꢧy}d̙֭3{^yF͛4iR)am[η69 ;(0׻xteG? 5g7.w'!FS]ټL8V!֢/:ƮM)E9й@ 8tS6RZ.y <˗/'HG -n'Nq7S<f@)yH4E8T_~m^MطomH$8y$[F߹`8ǀm_=h m>\ZgGg_\eY ӟnOSNͺg9HXq&Xmzx`y 80 4(ZV:lr w[]l~ӡ@-zΛH[]yBؕ#znnE9HK]62i\4fA)  i@/*F"M}4F㒉W;V"iI1PHa0 # |g#'fP4QKҊ3i<¡"fN\} 9wiS3x0 mHFX Qw:zr_V?ƔQ@8Tȕo0 L3I,~7g%_ƶZq,#\ <|s[1" B>/7aYu؀@3s޽RR2>jjjjv#Mml)8w'+Xv av}:JX1)->S-ƵV{szvˣqNWUWcRhmT-=zD t]RqⱸlyC5!t4M  ⸱ʱV:>8D=ZgVC'#}y|'μC.O!@|>/N?:QNM݉VG "F .Tƶ= A!ɳhmBIJH@H!ДDiۂ~@"d0@=S/ȳhm)¸je6~1 i!;k%b{0A"}Ó'Y:&ZZ8?XP~@)(7cH7^qdGw΍g1^ 厍I3nu%+M  (Bc߇+ pGmu'M8\t9-<ϸYRk)867ا{G*oa)s!CKҫG4ij-J_j9%iC)I4wQ;EI@PyƾFt/*="]  ҝ?f xpwĮ}xm8MRj=NuI,;}{U,nLGMw5V5o Wh2ڱ;𧾝fm?Vby)E<1(Ya} %=%.0e0Au,FibU-O`ښ;y9Bh *>ptX]PXНES\°cZǀW)C}%AU9FH$BPHa!=u8q M\z2MK#qn8Tg =AGRTЃ5GyW9cmEx(O;dR vEa̚t y¤ ){,|-1ajUYf;v@(d曁4)͜xsPQ؃Rm{ױ C]4mrl=}5v~ }=Y7mSTgw7y@\ {sQ+Vhx/2XcD}ǎ t.GW(*s }ٷIH'SD =P7kpɜ9̟?K/k箹Xt)wy'Ye{9_5JEAyw.6㺿wnzpSRe{J6?A"btlf͚żygϟ[[I^L;p3馛w?y@f,5aM=D!Ruw#V#͠zZhڵ]{,ZH)7.Eφ;dJ֭[6m?pgrߞ mao'lp}رߤ;v6{1v~;gSL àEuΉ+2_IXxǫf(ȧ6auĈ|Fm0&XLҕ 4GO? -OWH2 1F\{ݿu\%%%CqS)}?dV\tZ_cʇ2ާ+{OJQq8ahK ]3H1¡̄@($8 93 hx1zM-N`& ]+ّqVܸqΓ68JB5DApQ>pv28W>xj$Y :D8G0&$<PC~_;)V;Jy%JJ@F5W1WE(Ca(׮I(7L=Ƴo=˰%Kc%4B^~(@(!t!OWdEf(TnH;",[ÇM61SGb,X(]<-oAL+O v8\I38*-a#-ŢEu͛77?Yn;w9an}i@i@ ش-$nTJC{A~3efΜ _O<ܹs4iRٲe 'No߾ǷxƲ_vܿ|~#l>J:Afhy{WizATUpƆ شiO[o[n'RZZ Ν;3aF.q݂TBb=JIl2ہE޺T%6l?ίkƍ4 ]י0a}ɒ%L0˗gɝ.+2 \/@ɦ]o 4͠0J٨)$I̤IL`KV[v69Us4{=N<ɲek+V?ag{9/_裏1cFN0.<Ͽr+0aLƍ¤K2q_"Rӵ Vog>mK'oĹ[%RYqD<G/`*|Î5lw nY𒲴TWK{޴rK lgZɓVen :+WgϞM>7uji:QvzqAz_y*;C~(++s.6Րcɓ6I)n}/ Qn,^ BC [|_cKѣB:t( x u1k,}ee%7OKg֗'|"ut<=9uoXX S@4T4[)4! |Wnuu555޽QC aŊs=ݻo~?&7 YKFŔu&>ms?VFiJrTąwJ*6ݙ-M,;--羒Z=޻p8ҥK}#KJI/5&q{.>-ϕ$Ke)L;I*$uMɗOyNbYqrI$.ܐe9 x衇x3p8 yX$p H$.Qn=_!/ٟ,,8&q퐑C/"'%rIGyIe$+廉FbXX^}ZCzx$ [ nrjZ҂t_(,Fb>Jp0qijZCD#xlc1eʣ!nY򍌲;U5G'v"$¿׭CwKBFJV,@)]tH<ΐrO [-L!pD :gJفg*}u2)*< ':_G/)cUF:[o- G 5J=OY}ck#'qDz= g),HtMURrHDIŬInډ:"rOԡ2+q>m^[/\r>s#7HG9[-ec<|gW0Pz@l9yn"XX,F4%L&$4>RUkjb|Ҩ5,g DDE(DL!O,J4%6t]SM7/q=[@R>~l @xA~<<JNTE"D"݈9E4#R':;V6Ҷ,J`Z b5 ==L,_=9ȚXaҨy[m[,yF as]ITXPD['QQaX:먯Os]뱉e'IZ (ZcƄ%ic.w dbYI;;ZT1dA~@8TljK>ΙH%<ڡe࣭ȵyB>4&O 3:Vn;}63HN赓o(l`aBz~{ NNJGOfoY(ض7$M^N^zؑB};%?+ROIENDB`move=1000;blend=1000;3EDNB1hK| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ ,Bf *H$JI"""""""IUI$U$$DDDDDD$ URUUR %T"DDD! UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN  U_UUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'*EJ* R?֤֩5jVIZ֡BV*"#֡ P/TQBF'֡i/ZkOUUԕVIZ֡PH$ $I H$ $I I $I$IA$I$I W Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???t"t$??Q@'@@A@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5'PNG  IHDRc IDATxyeO}L& H!@ BA@dW-"/ eEuQ~YYXԕ;9I9 9T\$'>}{ @QGE*NHDP'O ҝw󵆨g-'=>7_;ëqZUp0x/;+%?gǎ|wݻwtRN?^g䪓:?K&?C466xb@P(cfΜ=?-ŋY`Av0ѺBTmo!m?SfEG^omߏR;we>.o{+ @js=SO=żyFTҥKhgŊYuֱn:~i?t۾=êU5+(@XPr嗫{lce P?+ص.2M[2M{D@#nv~_ӦM[oe۶m~ 7j2?S8\˽;r׫ﾻ'|i*t2l+2eYCN;'Sqm_o6Oغ=Q%ȞC<ox|Oik+oU!y9z, [l'NFx~~.WKL;C`ŷ.y|mCz^Jd-X,!`V6'aKL",XiHY&rұֲݮ??oŐK)-}Iy&Mĭ IEn80Ga2x%ش ^ X O[B(Y８Uz֯_cw7v]l J!O]0aBq#l̙B>s6reM`13}iRIϯ>~_w^/g>UڷlllfK/ 0 ժ/-矇㏇͛apmyKZЇ-ofѢE<裬\w<3py/ӘmU _0tv풯zEl;}*o R}+9~[Xxbm|9^P~ gŊl޼9q1cF|?sYE_`t8B.'!Rda"! d3M_[t*wkok3r&UJ* a"D)-ڭ#G?}lo{ӧO/@/4TNv vB-+m%EΒZ'\yg9ŖC$}~gp\Gg~}@y睬\nq7b) Nɛ7P(vL1PB`)ҩvL1!Qpy^}ѭp!c[%/oA)x~:wAqf ;cׯu>˖-`ٲe̛7gX1}0isx]uyEL? ! e< mg1M ! 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UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! 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UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUUUUUUUUUWUUUU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#UHREJQ*P-jOխ-u VT+_B/ #TkPQI_Z EG֚uu%kUR֭ik/_/$ $I H$ $I H@HI$IA$I$I W,Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???g^Vg$??Q@@^G@r8A@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7PNG  IHDRcIDATx{xT?kK- (P"(-mwc{ թ?CҤDCSmՕ2G]+ ހ [:ANKkK0^A`GC=\2w=>]ŢOBBDh0ie5fųaHD0h25uR4z!O ؋X\ހN2GwioHE 3' _rC8bZ$!udz`d`6(KoĠ7t?Wݴz#b?_ر|5H$ힸl1r.[5f6!"xh4Nߐ>]HTi:t!!&ь,f CBHh;U/K;RfmS7 I%J4Fϗ1!$&ƈDD!D1?c%>yYc2Y8m8lnlg#l}ud߼RWp!!z@p;xwY-?ɥ(ű[]M^Ŀ|gܺ0o Hh4֗EkUF&Ġ7 q !REk8pU9=͔U!qfV?콙dbY $㴹1̛bmgK"Dca$I2#t‘  N EL(FpIb,}yzeI$;@0`%/XfF CQ>9ό SIFSE G(x OUHH_J2t:'qe?}hQ̟gܞI_cCbassy61f9=}XL6 z#lڧ]P><Ii"! 38Xei:I0' && ,'q{ʋdXc QWL5j;&.0m_@9O"ue2I 8n܎R}#D1N$T'IΤ>=. $Ӕ2׎$.0L:[{DŽxڧJCd2ʃc}g8pX<(Ɖ#8ƬRVT5IR 0o NJg׎l't =G:}9dYr# .G飼&@;h(>qT#6|̛-٫ʇ"{ H?$t\4r]ɾOvOOuf{|TUԒZ)H8mK[eOMrF,.9޼I Gp;Jqڊd}os6HX=i:Aꢢt*;{ZXĒl /K0LPR͎ʺ CَQJՍdlcul'%+j TC<HUY&ڻC:l'\B,f;}ܭ9޼Q ZKGޖ9| c?Ċi8FNw ّ‚ t:!ŵWTȄiWTLs26t7Q^<!Qe Ԡ-EuWrì1ݾv<6BA/h!.(O$0L,H,Q`ҩweY@F*Jnǧ,sL@6R" H v %i ̒_P &m jx O#SS-xAmn;dz45v_;o+N{X0}BV7r\8E&]lX0A;,>9Y?cC?iCDk׿b˹ȹIm^L,EDz=&Si3MyA?Ժ#‰̚iK9|2{#bL6F1AjHEEb!܎Z:@0 V.(ũvuih2@j4mmN1'eF\deu(l!d4c4(3 YLweEU6%$=-\vѵ9>czw렳Ξ~n)%D$@$b1T)?cۍ)/q.T5)Řk4]= }y=z Y˪_ᤉFJlr1jk(]\(V- g]_ g6AnTUNmYQΞfJ /HIKOfKToxƱݻ=z?ToͩC;ւLF3Gi5o>G'x`0kƺun{kh4arٰ.ydБ̙97d-[ wѣGinnFE֬CF"&M v Ɇjyy_mmD=GSY9ۿ%e<쳴p=srnƌ^:%;w2^gZOo_'cfVX7(o/FN'rvbڰ/=a[gT_0VRR7,4ӧSVVzcʕ47JĊgݞ$ xhi?BKQz[jEt6Ɨiz~F8^\\{@Cacʔ)TVVR]]MWW;vyWa2YcT)@! _ Gb,f;7gߟg|),T>뮔Ft::tIR^GD>&dI\YQ ngQ{!7H,̯^{pށ .||M ⩪BE? SD{UU; wA)X-e@{(-Em||M!DQԩKXv:x _w-IMC K{"X5[oJ %`0`O3#᝛Z$)"%SHKK|UXUV,ՔAHl$ySضmoȃl_J&HټP []Xvb(}c뜍8h0^u*++7oިw˷-LÆa>HtJQ[I<{ʍN<'NexG[xSlpL5!}C|9y`~V[w^{-ӦMh;wdΝl۶3gRWW2b8 cQ|OV4yWmKL4%Kd뮻n _M30̈́#!^ߣFKM3qDUfygl8N9qV.ףEHeroV 6d<ʲFX6]S<בl0KR 7=j6s^% $Fk,X^Og?`]߄~C/_Ζ-ïtnv~MB6\9V&e < @C}X`L{L1yρgLG9Ӟ'H$ `|!W7!^mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUUUUUUUUUUQUUUUUUUU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKj*HUTT?TPժ+_B/ #TkPQI_Z EG֚uu%kUR֭ik/_/$ $I H$ $I H@HI$IA$I$I W Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURJUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???m/'m$??.P@;;@&%@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8 PNG  IHDRc IDATxwUչk: 3ŒJQFJHicF@Kh1\K5^߼oIKTX(ł@@`r.csrp~|6{{9'wS1J$:u]W4MЧWF'I@J$W;>า1Hi`HR7RεyH yN0 g#L ϰcNF34 O\D<% nj??wy"NGUtC044]EQ\H2:Gգ蚊hzW3#7ZEPe+R_KF<1#@f<@^]uA|,$Oml޹9R ŐR@ Tm#/uFrHʣ"O<:u4غO X32ɂY&iCZ$&] ~v/;R^Z\G_,Kz0QaϾjڪ&ĉ,hT>!5mNJ+#^b˵ dH38rT!mj .3bS4wyp n{¡94@i$C}^κWOma⻛9$Qaz^4-q-#^{!B1H7ލS-7 fJ8weLˌex;ݖfРAIUqM{W=H kƴsFvM?p}jpfP8@ X[4'ŷvׯgIo?aEo}8aH{7sW 5;`UQ&2}1-B!{8q"wy'cǎsMs_xi }Myk bXr֓5L6_իM3UXjƍodĉ.N=/ql~>y0׮O(?!܊PqqkCT]ۍ>)p;p's;ĉGee%K,wo/b;{ mwo" Pҡ>!\L=Uu/48RX?`ҥK7nppgitD0{QAailz0%{Ǐc5 -"' V%SZ NSYYɂ x:t,5hQ &!T5BT jQ4´0{^p1)(O7MWvKxF3܅:KלYk6.'71t(h``5hUbΪq}<~\QOA5{{1l4RJ{kf_pf[GJ:=OY< orSSwWN/Hz yM/%!CF1PXXg^3-PGM=aTB6N |kp$ۺF8\WEuwGT ;):LD SܽGMIIT#Mo9d|U}tڌ?{`ލ%~ohյQ(h@`Jc3P>ZM2k)| 6:?mGH4|i莽_P:L$$E(uk,@V' yUzϓGĶn4klӁ-O'XeNYY?Gx6;KP]n%:L;p#|ee} EA nvk[mG̚53fp7;٤(N9 3T{L\nR"H!=(.nVjۇ!%;n2BlvC?|,iH–Y{ y z"agZj2ian[{vykp3o<*** ZR՜0>UUUL6p8̽lm>ݪǾ0ڏa=;55,˃)R(B@c<.lz=;FXfLJ[HntWH$O^PfoyTTTFpn8x<׶ݔIq1wmt]k&q)n˃KqIqH CC5tC7X([}񸽼-i /Jؿ~ꍔ>GI&1p@,XwuEEE'?i:bS+6rYrYUaǴb-<7JЧzv ۤ,^R>:⢾Q( !el}Ro:%b8>%)-.p xO3|Lϝo *˖-/il1cSL/nߍ߸χ3ˆk@oE}BX$aL]Ẫvշ1)@I}݈F|'sQ#xgSI}_ԩS;wnM>ɓ'SXXcDy؅$ω7—7|4%eu-{MeH(?g̝;Uq,]9'XhQ8m1Z&]A|hPq<^qI1x4S}O(n(%#:ް7- Jѽ>Oh Gd0$νI'رc`G)K:֞6)! Y5U2Ӟ${v{)7^jy0-|VITi*C<g2x_SO׿ͷ 0UMnd@ӣhzC(JȊ1O*0uT C=g73fp'r~k3O~ځѧx ݻ kX՛M^ucda߲a,٨,^~QZZJQQ.+!\#KsdJ3$ґ<4J˒_d[o%s=-מ6f\44y^.u… up8LQQQz1AKq]k %Ў=X~D|AaMA0]%aiUxbBXm0]5WFDлwo~&yRU' Ì#<ƕW^I}}snJ!M4)yrp/=)}̂ ={655ܚyOT WسYԾ> .?5˞yhܹs7n\GzQ&Q[]<ϯ-g)m_*>.uqE5~_  Aڙ / Yt)+WdÆ 9ۆm(PTR?@[c&fΜ)˜1c4p8̚5koyH*o:j (ò[L5gB&0qyx<~>$b֥3 )N?Ǐgƌ,_5kVb„ Ӈc2vXV\ɶm8tBzUW]ٳ;У>sݻS<̧Rjk3pQ?իW*Æ k3y>C^~esV~?+V`֬YYf l=4钚[S63k׮egҾt<<쳬XUɆpƆ.%yйvZ~Gyo̙3v`Ki%kH.'yZ# mL #u<-[˱%Te.rJ\0g307sٹZ&i?w78Xyf}M&4zni?]WQ(Eբ|#X/)ٺ'}㘣FŒLCbf J^gH" #Ij`TL*. ag7Z7Ӯy~t EJɇ5ȱ ϗSs,qg+fRVb}!g{M=@ c)t=yM'BI0#9KB 8(yw<6TmiYJ _L8NJytC"% )l/z ټa[R4I X9c Oiâ}mk?ճFȐڊe*o!@ kD8΅?HZsԭ>%v1Ҟf<-#_}SsiUakG8ʲE*D֭}v2(-Kx70 苹q_1!9N#y&INyGĖk-'1w\|eʭpp-]7VVys~`\u IJ=/x^*ka#tàwϣa#3sesg8+bH&'%!G0|;/mƋ+Wl`kiU۠(.lO$![w)QZ2߇gn.ijõ8\s`p4H808 _O6׿56lhӵ'.FJiN2d\ŅWZ-\GQ:z:Z:jSE#Df>y4[e޴ZqR9[ X_n D8f +東A[T"##%'"zU3i_Бud{ D}ߛPEJYG fIMv&|-ξ?b.B60]l{O!"jK6b$>v۬ ڴΚ|ul]F0d Eo;0oa^7s$C 8`K4|vJJ̝z}U M,hHSEcO|ebde+Ν9TCHE.%6(]C 7>Of0{b C' Mx*^/y^Ig5IW'Dբ˓''\S$MB"4BƤ $ EHPRQ3~SȶIW1r8N$ڸn<3oY&l]dZEŤ+l LT8^j%=S2Z46|nݐR*! 8!Q0Q<1|4_`.<-T~ }dpcO๷_J4ɳ` )lE74T5L(RO(RO8RO8j9f$~CGs)?XfӮJ0|swyOC)9Ջ#L$$#%''R>ӿoV/84bd:D~N;B(F74 Pm4:tCsiŐL;)ey$m&ϼ7d54C%-X\HTLz CGӣHv]ydKFGMdp@ΕIENDB`move=1000;blend=1000;3EDNB1hK| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ ,Bf *H$JI"""""""IUI$U$$DDDDDD$ URUUR %T"DDD! UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ u*UQT$BF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ WB#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_X~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ݎ$??F@Q,@1@?(?(?(??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9aBPNG  IHDRc IDATxw|յǿ3%K%˒lٖ{L`S^ !{ <HBBB!1`7YVj}jWZId>^jgs=w$@p q-<9̦H"Q?tF B p!GWٚNwOx0(.Qf  8~ ϣ~ʄ! 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B_PV}X2*>;a|*7oG嶟<̦fkK T̈́܌1?tKpem؜mV3`Y#):W6?~Qf{_뙎f̊=G6S]s3;4"æLjNΝ˽ܹQ5GX鄂IL; ^2 D,rOp$[Ov;u䚬ڻN3ע ny ֗{4bӦM̝;w}˗/.ɂɗ$3m#Œ+RO p]V[߲0Vu2Ft"Kӳ,_ܧud IRK7ZNj*v]-} ^AHBsvqNH<œмgrb."K2Z߇w6?E] Ψ+&E Zu3F*]kFh'\WG_?>Ż>0]aW$a`u P7ۚXQC :SJb1L4]xCEI,Y2\_8BtpTlVY+dYwָM(j<U"FJ$/k<ÇN oJ@ٷ? jYI9uã6^{+C3;c/8q8!l!>6Wfk vMTD a6Eb1GikԦR=بDMo)#غ߯c"Phwv;Ck֪em?]N-{B/R;9I`4yޛCƐFLdiW(și GPMۛ&~g_K%&* *ۂبTU*;Td4 _^tHi`nA6K! ԗ:ڐ$DG% cPpjmКjMI]2 Oy}mɸ+`(}_GQw0yYDv(ol xP B9j7L#DN(HкWHDax.;oe$34(ܧ}l'u,J-Z" AQlw_F{&@khv !Q\Z}{(8R U(f?ot巣ziU> &т#ӊII4F2â7qjmap9ݼ~pp_!j6l{!5/x7G,@KT !a2EV\JQ8yKN%O~OLؾ"(KƸߑDXb0LddpQ?  Y6RkȾ u\Ey9\u@Ws-Tz?-:ZANSF/͓ǩ/ %1EPU]CB|٩BMM5("#b} e9QPn2.ǾDQR9wt x$&nk8tt bb&_Ԥ\L& nx<..&?e nSFzgDzr<$l!.f0$ST)E44Wi%*21sB8kν/c-'g'#ڥ$@%!im'2"lݒ/][0LX̑:5а̱Ȓ=G$L.@񯈌%*5Ǿzս Kȱ=f0;~V ^^~?og8] 3Ʈ7pͪ_Kq^K>Z>,s$t٩N9\vstn(K2qZӷ;b0L'ϻ9=6 9JIx&9Eqcs[9@F.{!Kꛫ0`bd`+RX.ڣl>u'606WQܸv.; 5E ޘl1A%]dO56(n,]y3{ ~[++H˫gnJNOGQ\BbTt@=RQkL 5lVp|uX̑4J *:읪JܾXfW_(n4ϤguԢ؝mZN*X8r>g~hW8Lin̝1ŸE &mM,r)$mK SQs϶qR}qʄGQGJS㱥38epinjk!¬yg_E%Ip3݌3Ʈ$#@skM98d'pgEu#K6f0Z0h=s4ёq̝"#b)cޤHO[M44UQPByMQ~[qhRMq#"I;~̪?){⦤JvHKl4c6Ea1Ga֞=dIxܴ;Zhfoxe8uGcx{j1iՐe$QR7$F$cH:`@FF6P^ S&)0p8))̝J[{#ǜـ@>9lV[#'8S!_u=.[ٲ_!K2z9SVPTb԰H#Yw`0uk7|>oR8ƬNݗ%mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDNB UUU}UUUUUUUU_꪿UUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUTUTEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT@QUUUQUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K||| BUWB*OQRTO*T/EQTJ֡EJZT֡jZԏBZ&ITP-jOխ-u VUQuP *T*(UTR_TQ(TQPR?F UԟZPTi?W_WRVZ'j֖ZBI H$ $I H$ $$$A$I$IA$I' ,WWBWfWW #UUUUUUUHUUU5UM5UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTQ *jjX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???$??p9@j|+@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10MEPNG  IHDRc IDATxݝwe?^  $5RB`W,""WTTzDW.MA RHlﻧc9gٳ60s̼;3<>Uc+g(NjH֎:<<RH)nR?.cuxIwYQ,!i\n HH4RGhkg]CU4]Eut I)ǻTOD%xQq(+8@Z&n@Iwb?B@g-P@@0r&w xΏWh$jBp D#x靇sox۟\ x A&ih98,m : fB"RLY8N]t)ϼKj uP`¨8T3;/q:iB(aϽAaW2nAirlDQNcX}C2)hj¼r֯'^oҜ8N<^/ mvĢiyM?`A?q).BH#EʿcS+A(^)%Mm5iزZ9 iTLzxXr6ol|/\Sb@(pq:]H)́#rXߛoQ|T0Yfcz}t[ E:(+y x=<^/*ObE+B4EQ@Q~?ܽv}P>¡8AJj㒄00L[AO2[r\:íQӗ\Cn#'[#H|sXÈOINxdE7fOY@b@P|7@JE(Pux$?E:TˌF$R͕cρ#ϱg# ]Է5e UMa^9]jEc+SrZsR@`C۪b[[̛2ka  h^|^fN\̮Hc+΁*u3kRG b+=bjEbhA{Wc+O *B(8jjqA(ODM٬'HkD'[@f)!/ yI׵AY:ي:jcCƶi M$8 5j{X~BBx=H?t(H$d)@Z KӬ(1JtzUKFtqkڟ+K'rzI$_`ty!&H$$8j")ȁutBSBGw3ds=N} DA<B(J|F*V,!{`A5Y?F-OP*`}ҸC 4BWL, M&xv \ uz8.t-ZvBz%C;p8\X\͡8TZ8Vꎎܰ=R"1]:q(c9.u6z9c{xy);FxL`sb0>OUQs;zcKN7@az{N ԏ |2MOPKQ`Ҙq8躎8JQ}x>^GFN&ƹ;_=^ EfQZ488P3t"cʦ:VmnpJ';5vZ4b&&/š8 OFs*MW zp8(Ɣ@ n:I3{L={;ѳq8|PU$ "}.;dRWQ-gxڦ}y8M6PcLP]~Ω;܁ũ,g/EQPH:_znmH}wuDjPrz5W^~C?GIC!F4IK qp9=x\>|5uU#yJ Frǭ(h#MU8 OQ^i/2^YHѥJ}~@ ($8o쥞lzu}Tی'6$QVYji,I#+FqT#wF"MR "FM UO^똩vyq:(cf}@-/OQ~9nkqSh,L$̉'G$yItp9=6àQMKWKA5>: 5k{i-{2rX$/A-sCqne#y +xp| |K|Db]/i2 &"șu;.ry #%>oq3{Z. ҹӝc qLrT2q7r\(Wb_./~9+ q8؇`lKI$bÛV-]׍XpH,D$+8.. muH$Dc1A#DX^E(L;tq:\* M9j\ Bv.t Mj*#&8dNuv0pyHg-̟uI@.xD<eGJCD-43ч0o F9(tvzٌFOp&L5bYuL^w`(3l2t 7htX~♨J4%E4'DaWu?B#~ANŴ  ʙ1D6n 398`:C-dtԴjtM׈'bAu=UkJy4,jʆ_$ljc)̫p^*ffݏ4|Xz#!>ÉYjh 3VZƇa5 rی6{}<~Y#)V*wIWwd4(H)\&VpY~na`VV\̣MQ8HGIڋƢZ\7  -ƅ>Oޠ I. RnJm #KKf\cqB0PD<7>a' !Z=hR\DrAr*Ln}=ÑIJ&À{0R mmm|MzB<mcfAt6` 28PA,6, N"EI$w.Gxs~(;dRh [Vvl_}P@ ve5;Y6n?x֎:{},wf1 @1 Ghl'Oq~>,)'ϓO\NA[hm<:.7t]I뷕s)+G wGw3 u`}lEZ2ǡ9.[Up؜Ns(&a@A _= F~ ϭ3$IϹv 碮kx>0H ih9đƽimM'p3BLq5F"%n&cxpi߇cInMóʄ =3*/:ktzhl9ԧ]j$U3H$DX2Gt9s>+Y2bZOb*VtPXCi(dTGIyqh;7nZEzRi.3HE0 HYwsz!YK&7@- ' x㍌=}{5̩/T= 'oN^1I@PcfrJR)in=䲹aճ X] >~rvېsV| <-a`z!sKJ F:`4-)KvVւ?H7R_ Z ގ2q<6g }#@*20p`{,%eB3y'> nhl 5j8籼2o6W 5jm/CIMn8/\va]pR7H0.w+mټ /kky8-˾AIa-j$ɕDrv{JѺ|٠`t/䱆jaG9^)N?uDH'͛7s- s~aK[pJ 8 ON3R ;kX>&-'ߛNg}|+{<3{l'2sEaL0ތ~Qa?k|0[mw޼yiߏ9W_5TKSY:) $:ϊ`1E:vi L1Dӛn aتBs&RrU4cc0|{WESC_,SՋ -[cS>qLz"i'XjjdmTIj#Irx@k^4gg]l)1Yʦ0bFZ.rp)?@E:")q|KGx8c_81s8xCF8}zlh9HeIRcЏ4]U_d/=tۘ:~M=ַH:'V~҉ZvC꾩j`: ⱜz>ÑeH!&fMZbX_1l4wkw}뜱jƔOET:8X6qOݑv:C-1XzMNm8W4s *(<@8څߛGRc XR.7|!r9a*mZ}a?hO>$q,D"%餾uMhl0 JnGA^+T7cAc׮]u]7w,[$X7 y_0vyM\R>8箫d!zT+gI]Vٺ=Y ffTdh<8Q($sVpQ,[}^#+hj\W^72bN]t)O IDAT'(sj0=OO裆Rsa֬Ylܸ*JGnqo3@G&r )S&?-֨)(H_@(t91DDW;DUflmƽԷzZ; yvIU[ o|<9~J߄\7 MOv裏}?[JY q'$p$ZM]q =T53J}By<_ s~<񠃄Qe _y%y_KIWJV=[.nrxp9͝r}YSgp>T= tc@)M^W?~Cqҳo||x'iJ3\}$ (**.ݑZR**`]>Z;|F* SSy\>}qc+q 'g|?<{y }l./Y_WG?Hzrd-~ Ñ'+ӿ_^?1nذ._N0eߕ܁'pn'o\Ž;[k$MAmd`2uM9Da pϡ{-=ՠm[.gR9r%4zA{x=ԇmY~c=,=D}}"΂` L;1)/,_xv@ׁwwrzI$[Ȣ|OƟYvx;"q(datT.?A!y"bNǐaԪ3~,;)N^OЖfWqclH񞶆/]u&/:`);}%cʧG7*nz߯9.N7xG;e]EW8nT-NWw G[ 5@Eq{9_eSN/ӕYZu;n툭xLyË́7n]_ufeՆ |,_N42>O<>z;DXH{W%+`ĉxcfb&f뀲^GGG\|;xm#1ܣEB7y@mSlgwhl9D]~4pݮqɘ9i CJI4i`ٲe̛7s9V:/իDaΰǩ'~zΡ^V/˘9i1cʦRTP[;ʕ+ 뺝Iu yuݍpuf+=?`_k߿fsr[OAztUٻa tsO 0KOY\f<'?c1|^o/}]h>o6Í`%[>z3g3*OEjq:wx ~<M7ݔCm w5R(55ڻ5yKP׼/XXue#i"O3MAMScuI{MO>ǘ5ilŔODGk߫ɓYt)RJ{lha/`L4tF3|K&4b?$QtN2K̇){H54*v›̩0?xv1~XSR´Ն3dR $#q]|󥁚,9KUW]Ś5kx=ޤT`ZE8Ii: A^2,a{TjnzĿxO s 6s{kYѸtXUmdu_8k ~ k)"#pI8ׯ?,<BevO~ G@J 8~OI4^'v5e9po5U2[mna hY'k_,X7 ? H Inh7a{=|[)K\r%|oj 퉘8o'|qP:n@hO>yOeSզ+:߇\Oμpٛ3e ߛ/osʗI@?Tcdy}<@~{r%Ȝ9#A>]7< Lˢ YQ2Q!'#?A7y7451l-%Ƹo W뿏շ%l_ƒ _ =1N;m@FEAuޛ{&|w6n~ ]Mw5" :[ jPsdɜsX:^m B<;kofYZZZ'"x=2e XVLfh,fd)n)Xr%~;6,¹=y婢 p}b1W| CJZZv6j'\J fW}LjMam␊␷v)Sz~ _O> dYѸ<餓~#{\ O>dҥKW_-/체6On"g5 {쓹_Ecrr.2K'(=ntIÝsgx\68~$ н]6E7y\:73a} KUصkR`Wi,?s̞3gN]Dc!8_%5 5l[D>hnj JO QT"bX(uʸsW|V^yӿ6J G /+^8VJf8qBsS}/A-?P"+'Z319?OYe}Be[EDWs8z uIKc~DJ hg'\f)rz[1J_TpeJ=adiP 7a2 $Y'/ġ83f`g K R®9TtiV񭵣eS;}%sH;+ XovqԟZsͰp} /p&,GfY=',bL4aׁYW\0ʨᷜh::Ӹkb8lx[)+->Ѹ^(-Iu^s=L4LOl0bX'M$څP]7>)HZԊ 5Ɣq.H&nh@Zsʚܵx1so!r A:,s="/*@"GF'6_;NN QǣKK>E>:H^{Yo8qԉFoyWJPZ6Qǘi&Hp꺋Ϥ&ڦ*ds¶Z|ZںinO,eƧ/pGOإ1i]I<: dιl?я%0J#8B;agFʅ(N,N<`XsNt<0O)ٹN`DcGTcht$AUW Lyꩧ(i7qYH)4C:UF))3t2!/P/ݕ6/PLq~]6NRjhH_"/prz8\qǗ3]><A>M61k &S]ӌsCRO}H_$8Ӄ q{M+\r O>dsG%9FbGH)Ӹ 4fcʧ%؁0~Lv߹}m\-/P rqo#(SgS]]U¦`@g*?i@$cN2PI#8p$s++}*Z;q:\( >o`M\?9j#?PB\0|:5{:ƶjt}6yyd91Av=Rm?_c;d[g}V\`ԥΔqil=D\j%F,0]Zžz"_cԓ("Zj#`wG];xYlӍEqP_7i w5qq|L;9 Sa+ O<,FMfT %o+)iJMwvksvcs}[HH;.7:8z6 ѴE,{fcDs[ x8Q17*f`-N_]t*D]ze]]6"n.Wcd"n؝~ꛛH!;СUfY$]`LmSprL[;n)/?`/hm$Q.=3T̟q]57;܎%'ZTE$BJ.8R@؜&,sc}ẝ6LH%ZnGfn¾a-qUM0y>gϡi'F35 6N;d@)?cUNY ODQ8˧px<3ŖL*ӸMMnwgTMXj ^ם7Wh<%le\&,:n B4M5qx3J{W -ΧV}yc^  N6\ 5ck0DUW{/-qsmHA-,*VŘ74NZ ~>@4j5[@JBlUx%WQoH%Ci>PUW6;kx!SJBV*Uoq G;))ׂC҉gO#1dG!B _{W#HN_rvtQ [dr<eSs v3i0g'PQw`q)p8ٲ+;c4$'붳w7D" mzʒJEk^C}hRMg@x""' ]q\Y/֖ __e*Ф{(UM˘/4xB,iڏ @H}IprE8IWHB(άH4.WQ51KO*:FtqvP7 !`sTH;5|ܸ<>o@ m)1_H@{g#ij+BvQ8"R]PH_d9Hq9OCД2݇ ™;mRԷ 7f%O XYoD 8X={S0V0|%`_9˶-$8(NVLoD7#[pa}K#dXRӕd 9S 70P5=yÝ/)ԑ--?:EqrS>ձ _O ⳆGmUɬBб}5I՜'d&_lDoaިW-џԑߞ>K=vg.G;Qx‰dtTjVׁ"Z$]R㦛zx=fg LCe Hc@M2m)'#0 `LfZo2Xfu.3DW7$:FZ`&aR 8pCZo4 ]Ivs 3;XU*KAn`=X;exAX+wUKdj&)c(Nsy`GdKglʰ 2X׊؟0nm2+*Tf#MUXZco& 7)ت_ig08FM̘SoPRC68n2TMEFvXůrk]k+fC!sIDATA8x\1,aahiDŽ"#&]a|>Cv&Č '2u&kV @j՘M8NHT`nf7H̞z2DM7!^IfRf&zygYgqɛɃ($wkjO̺]B3CBRKgqg`jN[5f)/LfBB3AQFGsu./\64J^o՗bssRJbŷgPYqaD, fKr5! AJvM.(*-Ε %s<.?^OۇaQ‹έ O[ >VY6X^$?Ggf4]cԷz}5[d[/¹p-x&  UoZU5>_ۃ26k(_k'xܲU#YWs3(AGw3W/tIz? ݴkZ>tq9ݸ]^C+Ы<6 ӾryUM4JBWc} dnMؘAmqix{ خq3=c%H$bQiscp-U}[Rv}\N7NmggŨFU!H$Ŭ%?Oc/ agKYgfrtvv>A P≘v1jOEX*'NxNfHB (%XFFWsRsEJ>>q5j\I8֖ <<8J|&/Ҝކom̡:E %QbWݷmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN ꪿UUUUUWUUUUUUUUUUUQUUUUUUUU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUQUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? T_*G P/A"EDT#TkPQI_Z EG֚uu%kUREJT*RR/jIA$I$IA$I$ @$$ $I H$ $I?  W WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUTUUUUUUUUUUUUI%UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUI*X~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ӂ$??_8@| N7@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 116PNG  IHDRc IDATxy\U>־twHB@ la@0姣>:8#.3>>FAP@ّ-aKtWwqU^:?T{[ECME3B8вmc'&!}Fu~z4MÒ&ll6M*񵕓#ܷ{fO9!n}s Ē%찿Gv 3&. 3addSJ|Tꉆox&Ou#)M,Kr7E;4KHw m4m)"TN`Yxt[w#GAyV%kNv4Nipa1K IZ~ #[cqIK(-a̜6兗{j*5f!MO k% JxpL&ž|4RHԱ[&AYJ 5% Wo{O)5+KB}ze*HK,۬L+ˣxXsʈ+'yJ"y{nd"ᱛX?ټF`Y S&Mѕhqٜ}UyXL 2,l~ [uY%J4Mg׀t+pe:Zt^3L 0ͬ*ٔKE0$d%QI! S6 .j^/sEE* )Tl5: )3cZ[vܩK]23 $lT&A[ǁ]gB,N="yBQw`J|!ضQpFL/Xй:_&54XBtp0F4\NY&}Nj6I s]r,y8&f<>G4MFsY=i6ǐ6isWϤ/ B(F8rpXMT,_s.CQ ΓBꉔn1i$RqJKj B!ڻO %VN#}>w˴ e$ro8XJjҴÐ: VҶH 2IqUix}ϧpbH SqH:PUDIʲF\е$ͦA8I sK9ܶlƪ.ob"H;^,hY ͎Q<r/y]M Ah_jbIt%:HettJ]j멫YE6٣bZi1d Ld*Ngw+e։5 w$_8kznk~&='Mɦ8;!zR"4 :H@ɦ\üi˔ܮ7'0M. J)fIӼcpR;ɣ>og[X,=ߣ)Myny#!DRX5|Mv].!F8HbtlR>ob$ryN=%L7<;IU~Be,_I2$JJظ}M+aRL&8֩С,t&)z~IfTqXT1'Edrw-\?G ?-{OAy/lN ɢTfh O]SeP0L " qad$I$?FBE!%p8Ν;ٲeˀjFKKϥ͔ǪX7MTUP75M:^|϶!#+Sn Grv+'۶G?n1˲l=ȠҒjN=B&7 fwwN{{+L!  1eIc61N[adlA]7/0 #kpt%@婺w%b5p/rr-]6M3GJIۓ_{ｗ/| MԪRvuNvHŇ彝xys0MTչt#4 M<;[_aۏ۱GV~u/+XǍylE}~?oЍbi坬š>iZa 6<3.W({da;y xx>۰ak *erYAT8L2s)<ÀyYMO#5uM/swzD)rܗ-4B]wŪU켵.Rqd$3]d)V v<<f5/:xN$Mh980D n8o޼>=hnP11y-b}̙zakiDCHi)>t&I&$vSq8g-ۇً£x|xtEuꉻ BsӻqylMat  TzInx7}oSZ^z]L9+oiG3ܷC;8Ժ 2/V&k}_𱫾50LLjKslΘҎcG}\ꉻ0 *Z{icT`B$W۵vMW?>_t ٳg0-<]fg:B2M"gǾ Зﾢigerҟ^{ ´ 6a!SN PJRtZ $`L Hszꜻccw?W{obwnEc8kزuyD;KG]1{̚|' Es/i`I}780&V'(Ae-`J~/}ݶ ǡ>q,N:$PD+@swtn5.t%bI LϱWGH7#X{Ң9AG;t(8=憀?">1q%z˩T*͛|q]TL7Gpb)?_>*A#?}eޤiDaWm9#cG.Vٸ ܲ^hvynww"W^oƗOk{K.ogW<ߦR|'5lk9\ɷ\q𪐂D4<3]Gl e>/y3"R;#ۡg^׃>H0TTwLp_s?WUυ{ 8Zq@et aZ&ͻUh󫬪*"#sTpi/YN^Zعogӝ`*>|^?#$o{>oK_ G"ky'AYv-=_Wז-[Ɗ+\c@_)ms97N{ｗni.EYI Mim?mIdM898s۹L [)N" gm7SBhիTZvIbyT-  ꊓLwZ`1m߾kE}Wm,X&gnϸBggك~a~O}{BZW9An֩ {D$(Muf!wѽ}a>oo_ms5z'vm6읈 =P~fԚ5kY|9O?4/ a}ժ'ˋD.++N")5l:>T;3uj+ ӽh?| >_Dwt6KI~a/SϘImm-=ꠥBJZ=$OBnk>f?3wꙮos?MuӉw6~h{C>vJhBÐFTu'JfL쓯0gBI͛7Cѥ]@ƋZ7|3XGvk߃j **GAy1O7GYI ~_4n%馩fj8 #3‡ቕEs*p wJnf3{p𳟩G9S5먭l&wDZNh`\r2BeUXȐ52WZ;V @!P]{rl]y\{x? v"v-3}_W,챤>>ƕg,5&ku%]abJrFCeLx**j㝴*%4Hek4 eHO8ë1 ]{X=KnLadY!,uC٤2`HI2O%bJ0e*K#TVV xhmoam 2*0inM{{CDå1b*0?6*K5Yva'4y 568@B//^C$q:IDAT͋af)2p)gP7ȓqIgZƨ: gY,X@8 /6w9=If͚!hC$XJ$TFUY#H~_GeW;vSSW]KY|9555455ȳmGK恾30'%M6T':*J$SA{]tjB<N4-I^+mX{wBKP@ t>7EJv~l2}њbVci.8m T(չǝMqRȰ |t6ifcN )y.Smq8sW+!]1cSNW^gv/F ψiku/Jt?an=ގW8D{EJm=+afƭ+zݤ iI4 rӜd`_UHY}l:O`}. _V(?c5lqg6/ff^'7.砮r ɣC :tM ~9ɣQf )yb7qb)-ۮO}(i^B{[,<9u$?Nܣg'zkG5`:^m *vr' ʮ]ЋkJpɤ]|3gu=v~)9Z(.H~)d {mo/rc:8n: 3x͓mji2?sBUyf<D~oP^w2*_7^zOxWI@}}7;foŊrr=+-[&ir[ 0;y\7I&Oo pC"Cb_%h k>+#߻ܱ+V:|kKe,q.[HIK <@| JtaǾ=6i~wyg2i߻aVO(\pf~?NpWC"[B), b-Gd.rpa#?Z3ydjkky饡lr!j,ނz{'fϞ͒G4n:Ӏ~*K8rt_\ugt],jd$).#kʨ[ ]K/g1.5]}q`O1MdG,Л, 3j*bv?kY:,\eepxGؽ8DT&%M*딡*^wx=>lcud)bѪ%Mɦ)C EZ8xM61c ~9F 5muG4LHZr} i:#A4TNA׽82qBYMyC!4 ZZ[")fF$\tKh,V^H͢ЄH} ULbʢ -H̘]:in7Sܲ, Y#kغ獢MzWV j\x!O(Q:NjGWRHZL4$8 !#9a.0P =}1>x?ҼV^{%A$TZ;h摓ǣj Eu[ЄF*pAT M hfB,(?X8-Ӥyl'3:(!QLax-snf2Jg%-d^[ S)P.~C9 xHv hǒ*nY>-%Jrj#&ϋoڱ߭7^ܔxWq{k7a\X Z*"cG4L\W6:^m={ʙLj% pJ1*JI$pX8|O;9_ /鴴]UIB!E#ϬI1RWN ?*FYI-+K}#C3] {6*o#Ra Oee \BA3F7x?\zNj5|pX}A%: \ f{'{̒$0 ^݇rcTLM3^jʛ*o$,ؗe%vI5IbN~ł&TORZ`.O:!Eytx=>ޠ;*]GI:B9u|/ q#t ȁrxUw<"kUʽa 켼n逸wvh7^4ϣCsGIg:,)ѕPg& dVXrG=W=~/DDY2҂"| >cQ!"vywY& +fF)%l8U24-"VτY= UTmM;&]WA޷x!xuCqYiBGu[ApԎt$eQ 8QNS1i>&΢@b(>TrmEkQtG(a6 8!Hur8huctFڮ!cT6 Dx_^iAeZ]G,3M'_ l% 3q>[D˳:Rs"#RJj֬{7r4~]yr-]Qvpoo^QW56H)9Ҿ hekFf=фNSEU;I"7U٥[48om8r$ĺTY*@pSdvUvGɒ!6\™z|aO@B*H5e7ɼ<ܶ[r 3/}ޠ+A<}P˸hq_< Sф#4C&cu[WMaʄ+)}x<~"P)Po?>XMEXF)2v:54vOH`;^4RJ4q ǏGYتW5 #"g)R͌Aaudd*N2'$cڊI;~YU D{t. !4bJJ"n=zW XݭhbsIvIENDB`move=1000;blend=1000;3EDNB1hK| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ ,Bf *H$JI"""""""IUI$U$$DDDDDD$ URUUR %T"DDD! UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN UUU_UU_UU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUUUUUDUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRR*B*TEJ **?TT"J꺒֩?V֗/jIA$I$IA$I$ @$$ $I H$ $I?  WW Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUEUUUUUUUIUUUUUUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???~ ~$??HG@T,@.:@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 121PNG  IHDRc IDATxy|Օ7Œ,۲lyl-6v H ap dL 2< | 0$dɼ6<M&y M<R=*( -El2KU s&,<ǀi" rM]zUU Ez')̞mp{9iyqFԵ_wAhF]S3u1f]"H aƓ 悦ǣPPKeSC ]}nkL(VHʋpǺ B2ӤfuQPgp` mm9& JhDlA{:i,KU)$BݿKs-&8ʼ 8(E'Tx=E-wH8gB"i>l 5]lǏ)#.N Oz}'y(Uf۶lKޘp S ȇɄ-l5K[G!VqAp !J@PK[=\Q-F uMU5H.dA]'wb[op[c㪏4q.8oò-^ |>>? /{>e)[o?3 ¡Ej"u2ճpG ]}5-W!m3r \QWV 3AH`uM$hT`cqxk0hZU~$>.p8vz=ͩ`Ofuja`/[[وUꨪ)u,V>:(*/.;L1"Z  <0 ǣl, /RPŖC%u8?Skf8yDR8UPd B桗tl[UQz_sW ݿS˘!NICȰcX4{ w]o|(mdP8ڏ@iڹ^S{S4Sz%ŕ~ɔjYebZ&erpd:Y{ UU44-&g"MoP;BZ;k:*媜{/ .Nu$!+ w ;NY`ȶi[WPt̓G}I9޶oċIڶ-ygYL]UDM᭫ŬiK]x((WYw S 1n>ejųvW}F؂_`**D]4``h?÷F+ۖe[yuU31-ךwk*3q*r||5LF*ȼ"_13RV\oE넰!5ѽg#:EbKPQRKqQE~?dL-Ӳx} jJ t̓eNhށ1DeY= g_,Cly+1ٱAU]AAuށvQu)+yߔIW2 aa6^! !fL4MLLl" 1rUeS)/a{ҫ\"]CT45`Ymb;d F*hZmiܿ9?UPH u+WD`UOeZ<*Kk4ྲ,[̦m{-,kf**4+:9anٵ.TLO<69f/ZEUҜ7x,P[5Cu}/NeY=@9Łr#nFIQ7-\e40WʥV ,$+c @4<[] WAUūY#/]ʧ<6zF7tJPS1 !j%2]L`qf,U$u-UKhEu 5,Jq+o҅(lf|\Lk%XT`Pg|,9uށ|^wC,ns7b[01Lߍ /y<ҏ#ֶ-7%覀Ad "6,OU5gjwzܪw.٦0+ ym]GX:R\!i!lwN5 '+לPP˰&m>9@G27' $eH hnKP(h0ZUeSo1R6D ]@ w}㽍B2(*B9 !PI*aL[jz`X1~ោ;~; x>E߿T|d1p.IȠyl kڧrޠ4u)B[QI!tȹ?8k |{wַF^>m󧼴Aܥ$Ϲ0Lx,!Ry~b0g&DRQZ.̞\?O*T-b>P tPUVDO}Oz֟OۈxX"̕n+ 3S4&ô ^y Z[[zutwwceHo~>SLj҉0bf%s60H^esI^z'ilrl QUF=rr'Xx-npǰ 'A2H17Mg'>o~sPp*Jj,l*~_ppPgthPwCeC@Y⤿i(~r%Jf D!= (!`LFWo_s. F1p8=mss=~ Y&)+]!aJp̨_HUi5N&o^Ɯo,{MN*T귾-<믿khoo__D,}%!2 O7c^ދ.&ϗ`W`?LH3Œ@wK|sx>̙3x4H}! )5P ~OMLP486Gω%19qCu.p]wO~©SF<رc]+rp2;ᬩ{G&%˜lgd͜Zjʧ&^9 r{ 򗿌eY۷'x"kkկ~?<ԟyD3dHNٔsʺ=<<J=-{ؓƩD"躟H$Ι3ݴs%U9x ː3нl^!?$Åa%k .<|j&L`G*]GAኋ?9?wO=D~RM0'Of۶㏿/bΜyguàY1g5ɍru&YwPІYH 0!:E___N=pg/{8zOt96dp X_|qps>+pn ɉ=a ǣ>tlY8ArM>ndK}q{j|I>ώzL.Y  |s ǞHȄ"/)﫺i!SY#!2 1ՙcӦM|? ^$kxt/^݇#7M-<.e[\Qoey։իϕV|1( V+.,SKS7oŨfD1y駙>}:w}8p^\v8a.e.sx=~Nv[{ƲM/ҶL,1QNҿHʪ`|M9-w$^;@/| t|3fѧ{ `V}iq>*d<<"΢tG={^{-> 0!iz}$#9tևWqӝ-s2ٸFl[Y#a<}ugnk4uMalycϼ 7t6mUUb֭?m|Ŭ\}uuuMˆfUL,eMGhKI`H 6XFֽ;.\֭[Aִ~477|rna\ve~|<d16ll!xs Wml[ ~6|Tgysf,GR51/4U5K|k$bwz қbRz3SFU2Ng;#Oh[d׉bTMďϧHX" l29ŭފ444cq׉B۹)...s[f [l:~SBǑ qS3ls%k-lmFPQQZ ݰ [l7:;Wm4ZG>7l?{Q'B8lR"kN")mqNTM8 $H?='-#/,.>_=7l3.M)[25-W9kT?M;N HBp$Y>ὤL4Z=^?UPr-Y(g%[m$aD#Fˆ0b)7cǠWwi0l::B2 ,3A,'Ʊi`YX曇 HyO+W[p-˷\vhmϞyDf$0LhjXmGԚfꪛlD׼h`\iͲy k 7ܬcBL! Ȥ硏)3ߒ4O_aJ41l!鍇vFkk~5mhjhfx̔FQ[(jfڪbӚuϻǨn߽ޛus=Yw1g܆rm[dn'_x=[$|"?ںS!,hZüӪwKvx)%_~[oy}=p#CzuO}jN3'.X"[_*KŢk3`DgϡWBNZ%Y+ԛ xNmnEb}NDi U()d ҍ}Lƞ$y (RRk.w d,YB([u3nScWB8YٗLq튞3㾞\]!gLzGZ8At詊,ZIz*LPZDiIDAT~ >櫙N f9Oe˖ -j*𕢪*G[wSQR_dփevzsgQ)rȲ =l'?yӝCj$# =ҥK[vN'&[=i"ôr Έ7"č(wuR xe% +kZ^-2ڪ8uuVO%(PFC*yD>Vb͚5̚5/TVjMP>N\1h|*ᆌ B,ȦkKdUyW76l%4TUu1+:,s ogH/fw 2|"P$:r܌Ǐ0˥Twb>65EQp #8v-w#Gz2Jd<^|k_+XIU!IO60br,JQ+(_("@AT8pLbyAj")p<`7eHm`ּi(|(aƉ%"Rw̓2ɒV~_16eB䂂ɎHq^,  \/(--FQ$F‰p}nLLHJQi1rM] < bmҼHlUѨ W£; Ә=$SD'-#vHD0m4x]u/lܸMO9LPU--,LL E҆LIEawbp%*@ djup_Ⱥu&H2lW oN roR/D%fk]UML5_Pw.׎l&, ?aY2=_JO2LHc6irhG3g D OfB:̡?%+,x򡎰9P۶Ҳ8#~̥_}7(a M clܸ0cDc"=\7ʂ||AYq54X:{%MmW_+d>#D)'ĮDs@qpɥ .4ԭcSpl\qX1,>0v>xt*ҤQUT5@)nD( D>t݇}ATKp^L;H&V͜B#QVR}NN,-pm ^}䂺*NFj*¡|WneHj'ˡ.o୷A?躗?>b2ӡ$aTKb\r%t 3pm߄=8u&ߪf/5x2:Y쭧qwS^2O\<I|#MLpctiCNjh<(Q2v9 NwUEtdzI^Z\ˌHEQ( V2% ;?ϩhp),r~h"i&AF^"'UPV;7 jco}&>.F-xCD".O21ʡHX?GA=}@C1HȫþW:x"JO%uhq#/J(C$OŒ!kfS]>)4EQK>ܞ6j*S(19x+(.* ):j־τE9U5*ۜ 6QWD7Rm5}[i۶4w.)° {Uo),B^laS$, 3.hzki,fc 0 e|kfr5| MÔfLrr2#+~mgtnٵkm7>[5| #>dш2x_Ξd[K>.Xkb Ջ?yG^sIhPSyhW~sfUQfׁQrmz-X? #F(+_B!hjtИհ>B0EwizόFKyt͋D(*m*Hdˤ1Hj !le}AUAtWP=Հ/ʙle?1Tp9zںAQ8rj';pVHh/cL`S^Z "80DxroBՄ|?*j!s%8A(K8֏ixmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN$ UWUUUUUUUUUUU_UUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWBR/EQPQD*U& uT Uԟ֤jԏ5MjZikUR֭ik/_Pժ+_)ER*U'Z_jGZ֡jZPjZ5J֫ZZZ_P_I$IA$I$IA$$H$ $I H$ $ %WBWfW W#UUUUUUUU*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???jj$??`;;@@5z2@?]/?]/?]/??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13PNG  IHDRclIDATxyT՝?JwCo 4 *3q&Fq"c7N&ɌI^'fhQM2hL\PqİMtkuz=w^ꪦu9w~H8Hʩy <RC)!Ap e8q28Hy <RC)!Ap e8q28Hy <RC)!Ap e8q28Hy <RC)!Ap e8q28Hy <RC)!Ap e8q28HygjjN0<ܧzcmMMzc'} 念Q5?տgh'#yN.ۗҵuU(-ݏ'/֛V\c=5%Bi+':9Һ"񺳸`Tձ{zi,kH)QDb=oqOi:*k5AL[YYYs\co=&Uϱ]cw0K ~Kjkh:^Ocŀ#yN%Lr Ҳ˝Ik{ͭr:{Z0;nȌgב Rn!Xـ3#SPTP΄s? ⡫tv֒;t5:OF̼i{Mʋ#H2@2Vc攥dysDѥJDӈDB"‘hs/dLڜi>J}>"k׮m6֬5aZw}QY]]c*q4MWa4-@p$Fh>p}O3ƫzڲvZzzzXl eSүsrdeq}{{FϽ4-EѴ(Q-B0C(K(  Ut!@Dz_@RyѢEu]l޼۷i&̙Cmm-ӧOZe3K @d? ̻,  /' UjQ0P7PH4DKwg^c̓*+V '']᪫ /pG;4Ͻ!((.rSS``'=NB^L[g yjkk<3f`Νmmmfrx)akDC̴iF?Ao?H<6zӐ] y-@Wg+,.yqG  7ɑֽ-y|+_z'|W_}5WXMXQҷ9sr`۶؉HE>CDM4kCI\*i)y,|/_|_[?xXS`{XQxᇡ}|I`+jaѠq'̑EQpzK8ZF71;ٰajxr+!{`KRҒJ s+10߭&m_K[&Oa<#^v' {F49qyL5;GG6 'c֬Y3*m79LU/~r 1ԛql<*4:{Zxp<U g]eJSf>aRE[?IN58cΝQ_}pJ)뮻x駇V]<&Dyq-㊫Q@f}Vv% +T*M C"GtHO%%+LedPZ4MSEcYRGCA·^I33<y9f0aGJ{njI(HiQeR瑧p^AIvA,Xo8+f#h0l˱ },;y{a`\43fz" VbCٲ㥴+8%Onva^X^ Z;jJ SVR95y}˳}0 䝏_v_n<+yr [D,y,w6:a"0>^ʤVpu1lv`aA)xYxY_:sfU0NHɓU@,K!H&vMBK)t]̜jIhҢ l2/%뙊hK3<$@J#{I%@ąܲ!  q>.^O6!ٜ)Q5,DzEAբ-Mq.B%Jz]Ii+c? ǦԑRPRre7RBKsgoť(.\bEE(4.Yņ7N݆ogy,Uy0@( w_ %(*$ 9zZg,XeRKtA7t4 6yP})t!OnvChG"\% 3AH\Ғ> N'm\;[A `OW۴y%6mMgyr N7 ] \n\ksjOô} cmMHś;Zp SM8C1HBtWBuTKwPf[QM$C85YЈPAB(E.% r#Oʲ)L O%%t4W:fW78w >f,$RZ pZ'7жH) EH0n{ IlimofIL闣KBeTIv4;mcY(-媥›}[.aCB2ع/{.hH$lacHdjmDg'RtjiC|#ǖC @"d+I`^L)?!tnnؖ4M%*(B E,b2a^m-LA ϓm(B u-c+ '4/PN *?r^RnۺVzˏ Xc-GCutiH!tC y\.˄rM6zz;(/gFDZPX%y1 6n@i*]g'r|~pZ+eN2a P;-z,xzC݄#6mE+r>5"(Ѩp\Íq{x{ G8pH,_{TW+K;2@'P7پ\V^|+\ŷ}_sPѨDP+lCv[M:8F1ObLYR#x2(Xđtt'N 䧴p㧥oF͟W~ҿG $ra$zri=VV[cev[>ns;Ԏo@Q eOrpi\gKO #~ULcL<.m,0dl0id$Ngw"q,yM[q%VO_RJ+YqèZ4+d0fd_gFl;qn3wk+ q'7.u&.ϲF!rKR+d&EL=_<ݤƒNYŴ Xt`Khi?HO+:= %y,[ٺU"^.[xc<f:)%y,s B<#Ř%b"+LP^\0n2Rlͤw)n4]D˕KV3[ B~l፱*aRڡPB_]Lb:*0R$&<Uat4-J56l0^ٞ"aj u#M].E1V񸲹dbQs35+gz{ GZ]. !(YY Q(#BIxӞє,SjEJpXerQƞmK/#XE +ٔ6'-)uQI*K(FQBǟBY9&Fp4s؏ *g|N]Nn81I1ѶbMX0;""h;ӖRHLJ{ijX߂kWTmO3Fb3C=$ !5'-咟[+WZ0('t,~zę[ !}Z؟mp[Gex)!՝bRM I^OYBM_?q@h1!a(X2$\vm%U_2,)H]A( BI1I[ꤰafyIJKfvDsOcu5?ۗo&Y:sD1Jb'R,a2I4PЄ;ۍc!74CQ~BQvgij LYCocǞ>qL"Xf1Oic$Y@Ķ4^%@E,yGAn)E#AzCۆOZ5sEӒRsnԌՈE KV>ojp#V/֥d0\[ ӏ9JlXVտ%?ܵ >d|5zq)ns%|*548zbpŶab|w?~k}Bբj1Mhmoj KSbCu{sE H#,J;f8r|B(it9cmcH_"f{N]ӌ|BAZJ 'H4ħM1wVno!Bh(cIVB-!kA!]33'.47 Ѹ|MFn:&t-qSiH&KGiF 49IENDB`move=1000;blend=1000;3EDNB1hK| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]]IZkTZZKj $I H$ $I H$ @IA$I$IA$ ,Bf *H$JI"""""""IUI$U$$DDDDDD$ URUUR %T"DDD! UI*H$!$I TA$DDDDDDDDI@*BP I UT $U$D" *$$UTUTAURIU$!BI%TUT""""HBI$$ *$A""""""""$JBP UUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN  UUUUUUꪯUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPUUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/UTTRjR?Z EG֚uu%kUR֭ik/_/$ $I H$ $I H@HI$IA$I$I WfW #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUURJUUUUUUUUUUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???mm$??_3@&? 8@?u?u?u??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14L!PNG  IHDRc IDATxy\U?SSWܝ@0^EoĻQOpR}E RDЇ /Ct ^0$tN'ϰԩܩS83Oշ{B$$RQ~ccB}@% c;6cHqptA›#h۽ G3oI؎cƶ-jg)E}2HYI)A=.{_tI_Sřּk{;H_nzab28@G44#4Mhh~9ߝ-l¶M,w3fydA"EHFGخ4m>mLFvmOQ=h6:pz?m؎ŬiǀHpłDB %B3T%?2jk멭}n:B(Qᦒ~{;Jx #b<iϪ76ks}µ1n)BJ6|={rқ5m>h֏m[GA&1F3:vbcJ# ĴXv7+Y#1%ē/tH5e,)%cJ%M:`))|tl,4Ҥ,@t`&RJ,;U,M 4@|RgiRPxEVL:7x\RV]yeF,qlLGʦghD!a;fҼ[қhh5 lY_$ D#3 !4Jw/[ 4ţ,2B75gO+;Ç žXޑz)=]7~͠cOzqS˼擽G1nU:B0sma)L3i%1$)+e\6@GuO,@P`% _)%m}0D* j@JlG &e&H$8,xu9>iOG_$N"TI(PIeE-* Ïy-1"S|ib*Ee:oƸe[t Ri` LEs?v|>b^)g,AJ֝h|2}TGTQi ~`>\TV߂A#TGkBe[XV 5CQ:@u-ʂ躏L+o+>b>tݏO>ت%v9=1uJ4GJiShZu/?#11Ĵ2 [k:HUz"5}A%"Mgz:8Y۶]aX^7BTwXY3kۡ)"BCs簩J|ϵtuqk!n03)H XC{Md*6dZ ZNAAEpHE-YS 5Aqtׂtܮ.B4 txz6<9R< &&~vi]mNa)3kXZ3=G4b9&]^5/F'菸B>|<--4$jd{Ƽ=ks.?4q㑀mEbZ @CD2^/?͋4 $C+8Y@Z@wwpǸ4wIx2ɶo;R:R[k>~3AO:f Ï -Ro^L}MN5 uN@R:^kR "|vw #COvLǁ6(Sm>+$% Mф5&DJ[rH*wa63q{U蘌xP-Fr&bLRpgY@*܀DwI|3ZЄoG_Dd45"42EchMh4MZ"h*BN:"̚JLNQ' _|5`Luo~2=@Z8>ÏOW4 ]^o{ fBy$c9&ebvM[8^l64|yKeF+q,({;dLe8}dв dYɍ^^^4/>=If%OPZ=gH 3g}&ܢ?CW^_3TH;x̛}Q+2a뮷vLz/ $7zx-;^/FFf㽘|txo%ai(x9>jkaWQS9=*IYIu#Kc>K@mݷE<˗ömPY L|QQU X7=lb3nk8^L .A`h\K$TEI5ncFLb(x. o/k9P&PY(S@ &vg]"'%%u盅}"P|+;?#&)@^u>D^؎e{%zllmy$\tf"AKrIb^hAg!)>yOf3I =sj FXW‘7}=TD*>|%=Y avd*FQ0gKb~{Q SԻ$lXg}%pL>o|E.c7BQ:zջ}U-&f4* ݴnݺ/ "M93OB jf1nZ*M_8ߐy:;;ٰa?O3;_Wӯs=믿h4ʫJ2dǎT.8=o1gIޭ"aʮΑʷmQyS0pfXtGk}s=̙3^yN?}| _g?s̡3w!K&I,-lǢk/M<1|"Wo9LœO>+DQ~7+pwg&~>Oh"/I'(P]+뚙^BP02r`W3b…ymӧe^.u' RҶmz;;ټy3|\jyѢEyK/1MSxZ@K}\^/:+V.1WFyFdyrseuQ~{ߓ?aO?tIir֭ίR_<~[вdiXBnڴ)W$Cmä1|GOQVW6ʚi;5gg-ov/ʍ7իW )w}|+|Pz뭣O4JG]v GD "fzժU7^{#0u_|O~";6!q9p7o%g5.+g6=a.h>?oɵ? p=|Ͻwy {T$OOCb~w+GK; n81-܂kr7D7X (ꫛhBr,/Prꩧdɒ]x3} =JVSIMM TUU?_IL.2UۦM~e|,WX}^l\l\reɟoŏrZ̻'xx衇طoߨ'zj?zN?t^~eunB ZXw / +׮];[l?9~uɫ4plmf5X0t.*++9cxG;w.3f  DZ (w -psHGETEeI@M'+yy$V\IKK RSSM7ϗp __~ZT"hضϡKXřg9e]Fuu5=PQr pRS[zQX\*u 8zrѲzj:::Xp3fM8Rݱh12g S < ~{3izXTw-`%jv2銭4⨥n6x_z2l|h],9l.B Xni=~Tpd(ߟIUlq~l8?E]T]gpLZ{[*`Wo^BJȲ7=<^SofZ{;+P+AiYp SdIIk&x@YB<lZx&'wQ(:t{jJGZE '.lNvT‘8ԞMRrB]qAk+Bo:wBCA_tnв'0 TE"wp ba4ࢊ N)uFD \;b1~Y D1rFWfca;&cH=xXD2tъ|y\wF 7Ό6tTK<;1]R[W׳(D/D'\,Mhh, mb;G0G:cO}Mqjܩ> #s-&!fFǵ=׋ȘSW=3(9I3N<_p"%^JbZZ`j16#3o$kT,3&2R<1t_KYe`⩫huGFLOOFj}tgUҌ27OML֝ѓ!j(t&R4'Tibʨģ ehW$Sq8qkyU5.36FO] zku1t{7)3N2Ct|oyl$RAOaœ.T%QWbZ))U Ǟ= "XU(S vs5:v4$1t]'+C "^#.e&Hc3xꫛ\slǡ/6G$bZ)4!8aއƝ(wLmEmttt=Ǧ/znv0d@%UqY.WEų< ժB]_P q?'$v}3&S!'HBs &3nC7HAK|ws`2ɴp+G8"T4?>;BK[h7VVL86B= dD3-N+*jҥyj&D%zvtFAgN*+j1$>#@i(3q*4[XyGKa.M$b '[4mzayDTw[_5pvVW'Kdj lѤi'=q=MAѤgoQMy ^SG /Lʥ`BZ-NhXV*K8RMlG *,mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN ꪪ*UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_HU/TkRj֟BQQ]DUIU%IQR*U'j֖ZBI H$ $I H$ $$$A$I$IA$I' W WfW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$AUUUUUUUUUUUUUUUUUUX~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???gg$??M+@xi @`f+@?ξ?ξ?ξ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15dPNG  IHDRc+IDATxy\W}?ﾥ%VZla[mdls9a5d43Ŝ!ax8a Cb2Ä0Cb;3';ްRoXKrq_jU]إzUޯL ۊ9 N2cab !Ls#<߲y)wa  D?2#cs1n oĶ]t$:I;9 ;c)32~b[cT^7 @6?J2*@I0J)b[gp;8|Emam6!(JY G݆j fy&f2M;IIs8vNJq~n9F8ܗ b1셺I:`6iy_w)y ,W]v3D'X8o8v^{&-27aBX8V ێXqњsm^d3C<t${f-¦ld|h!fϋMCJtJt;),2,2RxzYk>)l-Fa~zE z70пT Pdr<o'MǺ,XQ(,W TcaXb#KwR$b$bؖia" &0PJ(%A7((RRJ^.c뭤t{F?O_n毾y zȣ#q8xnڜ84Li"K , cfdu&0 !ǒ-IJIJ_)dY8J"D@)"W^Tü~y^|2bcE:0?L۲b&t˵‰DG4\@՝+6S(fz$fn,;|l$gQ(BO{>_K~d]~Rm3:>XBSybӺ-LL ]4zҫ0xTL ӴiAO %J)$Wl56߳[dd<~VbQ^l!21JnC7,Z@ѼQY4Vc)66xe(0.Sƥ͇KFqqu|3!8~8m$Raǹ5Q,ƶts^V)agW b$QTkV\J|q>Lu]<㓟䔟I&8~G'WQrTT|mP:Ex3/TŜ$}]C~݅b \Dp╒">hҟR2jQXeJ90rL9EgCv"k/QSͮW䆫ߐk/Q,uJE+yS rcCGCu)\ͻF*aŠ+;v=^PPFd13t&T!f'fFwʜ8A>oiC?I{+D]:|%0 m]`*jSUX~aC=ӧҗDww7]]]$I$X q>|_w<ˆ_s!K<7R|;LT@{XtR{ 5s`(#\UT/i|͇P"?{<|{ߛo0H$˹s#m1Uw% 0DUZBj!+#ʏedxOeI Yk+I$J* f,ZU0僻$#D/NXCLiT; kfY٣El1SX W?1z!C=ѣGSi3+j~{$aJRzLݰE܍(o@)LH$ 2qJIL]Qٔ|o}nm<=VYPJF ޾ᚅ]Ms:',NTXrbC= %W%*g7.. z4OR6T͋8gWzF[45lgͻX/mh4b 6V#0B-ddٴVcX֦PYv,Xh#hSQ_?J^?ͤ@;ffD+U;ˆ^GxL`:1cr; rt7O୆XغXa]X4F4S %&KRswG0[X;8'paֵ6X\L=4ٹ\fPZDZ-+T*ő#Gmʲ;３k}5۔eOxvZW=K6`BuESqxfqI0iV&~ _ N@ouukSt[G?삃f\2x4zq{-$Vz ~mO$BDE[; |V\RD)чhMhRV!U0K!{cm-z̆a`(- h\C֜^hejģ Lnasb,.>GXQFE6SQ%Yٛ^0D;]͔Xd/}.„` 徙[c)ctuBh$B`"6 '*]Kh&JIfSMS0U|˲)D)c͵͒CPT4Ahr a" }[ff檏P9m#4cfmj,O([yn$0!iJnyVYD)#'BhZPXP0Z(eA׹aBmE(2$btD)),޶z[3lkęԭH%Ja[q6 \h,q&| QaI~ێ5ش6KIœ/%mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN U_U_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? R5_B/ #TkPQI_Z EG֚uu%kUR֭ik/_/*UGH$ $I H$ $I I $I$IA$I$I Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUUUUUUU_X~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???gg_g$??I@@vտ?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16$PNG  IHDRcIDATxyǿs10"3 009]7]?lM65ꊮuݬI4G4HTAd9Fzϩ>f|o=+ʲjC ~ ! ,Y- T^'ɶ$]e6_2? } h7 B/d7t_9]}ͅ}j9d ' Dy <IenK9ҽO(Of/nO$ =մ!,4Tc1kExhۜ`-iU&8&D. k|l i-mIt>S ߾/1Qϟ/q#!-G]bI+Lh}GuyʧX$Y޹@h̎N^m5G(o{loڏbNM{ԯ֕>2|W{`b$aǖY>BC0kRdee+=J0ocZs٘O~8N=k.1X0z[]hOc[r恸|b$Iǂz#mߟ I{x>3p 8xgTWP13 ߜ9gip]v|^-zl7#ΝKϞ=:thDY ]7mS=OZ3 (It:gA>gW_'OeȪ:x Bvء~`'c0;f w>m=T@+I'Oᚙ'Xv-Z*c[ ۾>ui9׋x#u8&tBCCbz6a>X<^iW myWF O(-\"x(jsqdM)ݍ_>2`8žǏiӦ=فO;J|oƶEBg}w[{쓁'E իW'+(k쓁'FCL6U˪߆=sĈd3}.OV+YD" ljS7gx;^[ N$^ unkQ6-8^5ڢ`8uSu> 5lK=PDE@kk+EEEn~lHhJ}x=sR* D +:Ust7-P,Edg'gq7$Ie:?Pn˺ E(0gڏP,SҭO|3ep|#ѣGsuQQQ( zzĮ]hjjfiiiQjTTT$ MnuP;D+&֭[ԩwu>hYt)Ǐ筷⪫'O>TWWn:iiiaAQZZ?9`bK?:fq%(ReهOm1 D<-gmyW2hР%@~ǒ%KX`ׯ{ 8߾}at֍}kݺu=:֯7M +gAno.^G4T n^au,VcuLpv1KQ< vTu3gtoa,ϙ3!Ch"KΝ߿?r 999]WIITv%3}:]v****ҽSF%1>:bxt//ˊO{Ȳ5}rY\ɊA SjBA# < uU}ƠpSl| u/zͳ>G 0oL~g[U-a&d n Qc@bHyg?Kl&>Z|9| e+qw}=zxݺ%%+Z]2E^)ijqEOnkU2!HDj֞7>*~8;cc%w}7'Nd֬Y n49a3<7N+FML&4B9hے `"DBUWWGuu5'N7MBiӦqe%zjH^7IKذ}P z<^P_Z^_;G"[\ll5^cfEZ(EX(n[V07tٵQәI%3 {/"AB+n|\ZZѣGv |v.bHկp3`\9xSj\s5Cӟ?#pH*+{n{ľ-Lh-AZEcY$ڸ`dYvI$"#{JZ}_naߗ[& VԿzջwo )9R;r+=_pҷe{ y'];_RZIp&%]mcm`~Y$)dJ9w\2:phm!0iE&H6$Iu޽{vKBX+F<$I]{U^EBl#ka-0WEEE#F0n8n54 JeS]]mmt-H8rMaGb5Ws6]v+,E( ^= q_E]K@ܥ`F a wK=LOGQdx;EQpEAVd*zFVd^]g %/_D]x$l g]qcE*(֒.)dGh1]+jWQkvХ(Ba3Qz빓܂e#}\֬w>ͅkO{^e>KO)EmBTХ^UM`tWQi{T<)W§?HMK.$w,^_aWFfbJYV E.dA3|[1v6^д;z9?xāxnJŰH=ݞ^%pIKD ٛ4r7-2>@IwRZS=QNtn貃pvdc GŶn>`-ѫ23#.F(2[b9E_ ȧyY525GRЖLwmѯpIW񅘱aը%8'{M,S05:dYzF2̵SB˂~l껢(%˻"'ٜ@&tRn7]")"!Qۅ#;"gISA2뼢*HVw>LoV #-r'7'OWrd`6řřTBfHs"2붼mːU +^ȲebcUzimtCnN>9ydyPZ;z,4om_ͷhK&DC.h4c|?,a<mwK%\rBQ䴁'Z}'zxL D+ǣ( q|z%&dMvb+/3ٝ@(2;Xm+q~_`-m'u(cv 5ۮ~ J%>lc;3MǂGJ 2Ĭ9M1 X(2m:rs[5Bsz- %IH<:c[ $aƾ,yeq>tu8=NeTU`tDZj?>- 0𨝕Lx(6IDUymse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES11QY9%%G ZBPMZRjoZ S֦֦֦jo77փPT?S֦&ԃZjoĄ<Xpmf UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW5UI$TI$DDDDDDI5Q$UDD&jUQ$$!$j&$!$DDDDADUDjACTHI$UI&UQ$$j$""""""$Q$UDD&j&$DDDDDD! $TI5Q$! """""""II5F!$DDDDDDDI$jBUUDUFI&I$$5TI$Q$"""""""""I&II$!BI$MTI$!BHjMQ!jI$$UQ5UQ$-binding site for residue gol a 1000ac2F 1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue oh b 9072ac1FG1met->mse selenomethionine MOD_RES!!1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES""1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1binding site for residue gol d 2000ac3H 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES##1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13EDN U_UUUUUUUUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_K| BUWB QDT/ uBF'Z#jMjZ֡ZZkTZZKjT!_j""? jP B_TG*UF UԟZPTi?W_WRVZ'j֖ZBI H$ $I H$ $$$A$I$IA$I' W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUQUUQUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU_X~binding site for residue so4 a 300ac1 J 1vbinding site for residue so4 a 302ac3&*1vbinding site for residue so4 a 303ac41vbinding site for residue so4 a 304ac51~binding site for residue so4 a 305ac6   1vbinding site for residue so4 b 305bc71met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1~binding site for residue so4 b 300bc2J 1~binding site for residue so4 b 301bc3 1vbinding site for residue so4 b 303bc51vbinding site for residue so4 b 304bc61vbinding site for residue so4 b 306bc8lx1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES$$1met->mse selenomethionine MOD_RES==1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???0K; ?Jphenazine biosynthesis protein, phzf family; chain: a, b; engineered: yes3EDN3edn P 21 21 21Bp[#BFC+???ab??? 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