W93.6-1h/data/swissprot/ 3DR6.pdbdupa 2BL1.pdbR[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Structure Of Ynca, A Putative Acetyltransferase From Salmonella Typhimurium[/h3] [p]A.U.Singer, T.Skarina, O.Onopriyenko, A.M.Edwards, W.F.Anderson, A.Savchenko, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3DR6" target="blank"]3DR6[/a] [small](deposited on 10-JUL-08)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  2BL1.pdb3DR6 a_3DR6B1  2BL13csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; 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"8^_FrUn\|ތE8NHm/|64C8ˡZw}X<%2nly}ߥϘ~F$˕GA@UTf_vJNv U7k%CD>wFڻI3]q$ 6BQ@pn\N]3V'u|ݶ#ZDC!ێ}Sx|vtϖ%rD?Z}dοȖsg|TRτA$(Hd2ٹdYN > '  XdK{/VK>Ҵpg_1`͔lWaY7-cVFxSB8$0Sޚ_eU1sz 33yk_z>|`xLNИ$r2J’3JDS<.KA'݅RAbI6عs'6m?$x4]./'"ӗ|]}my/mǮw׾iWiK=!BJ:{Z HT'0}~}Բ9HX|Ɩ,*ǵIvWV|hn߃$9|ͭҾNԝ\ÖsƂ5V$ /{ɖ=;_-/2՗Gl]hм u)VKD1y>wOF*{C\;og^@6#I&k<ɩ==TQQ܅|(cФhδSij*TKKGh/__KrqIq:zZH&c$5lʜ>:z̆:vPdg̨[@"*8&7@2ފ(JȭcM9޲N?=TY28z٣Py*}\yFH7]Tgr,NpHx2$Ts8}5\[pMFxSLi8 8磭\:q.'@yx|<χa5 @r ]|>^/6mbexLxp~_9Ec̺x\> Tחi_Iff_z5^{--bԩoF5<#z[n5ki7%N *W_rXv-֭K/=Ƕmy8|X"LwH?њv<7'iㆀٌ>v\8> 98$w9J9J\$DI<% $sS)MIsORS`J)Q0%(xJLI<% $SO)DS`J)Q0%(xJLI<% $SO)DS`J)Q0%(xJLI<% $SO)DS`J)Q0%(xJLI<% $SO)DS`J)Q0%(^0IENDB`move=1000;blend=1000;3DR6K1| ?1UUUUUUUUUUUUUUUUUUUPUUUUUUUTUUUUUUUUUUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW /Ij%/IK$U?M)P_֡%4֡UTRHZ*UjuPBUZ kkUT_I"UZPB11111111111111?WWWf#UUUUUUUUUUUUUUUUUUUQ**~binding site for residue edo a 172ac2q 1vbinding site for residue edo a 174ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???SS$??<  @@?;ݳ?;ݳ?;ݳ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2+PNG  IHDRc IDATxwՕ$QQPI r9 :]>x^?68`fcdږ d@ar MN'ttOK#y[o{W p_@\S@(Q O9@rF<y 3 ) gS@(Q O9@rF<y 3 ) gS@( (bjB<"2׼-($ Orr^y!] G} rz9e*~n@[ƕ}{và*#t$5_?9x k18oo<0z9X{҃TMZ/os\<ؘZ LΤj&UMeȱHcc#?|B^ݡb<.~_ U2qV1r<>@kji@iJ#_ 8t'WLj򑌭*磌;1B(kR1Pt$vd7}b.o!QW[EJ3AީyIc:.ϱ'> [_H6~qy8zXTí)I]4 vm@>qwjn4M,u}5nӝy>ywdϡwBClyc.Ln<rxѿ!8H{txp:\MOO<b\בIC~4!D!ɛ[X]w;\ Gr sJGӌi!%ky㝺 0i)~qY_$ MCC4^dBʹNO.YMD]8(C O ۏ) 0Q)$mۙ͠4v݁#>(CXU./4]rn;skXci+y\I D":Ɲqwi=@K{- čW}qgV'<)i8n+5kL:>bVH>u3̓{jq߫i(q#J<Ct8cOxhnr0n%tϽfW/O)הvפm̟q椬dt,yf4U#PU9"_)~|".;sn(c?+>E" ;n-sDu0dh|fpYb]I~%/"5,>=F[,[SSН\hN܈#4Ja_g…l޼9IK 41MMH;tˮ}]w@[} fow^wdGOHӫZ\X@`˅b̞=N0Q]rƝHi ɞyiy8Nu(3*ge7iղr`5kLĕ~+uJ"zYd ߸q.m/|ۓDl1M~ݫ`b~5q@;Lv!i}5y~_9 0P]7AHv[Ky`XעJ2J*BQT K_̝;Yf1}t_u]ƍ70th~W^UK8rׯmU԰V\sm2Y|rDSN Kl\W5N,+# hipWhBmQ>FcamB`Ji8|7xcΝK4eL2@}gy&7V0eʔ~y1j*|A{_MWWǖp﷝T<2, =s^[%R 7:(Q`)c'w2!BXB?2'm۶܌3RV$~Xf k֬M`ۏn+VL?5w5n@gᗿO70LzgTߴ-^$> ;_:nx7\ ;#%ʹ2w\+W/qrΝ}3k_ڠX |nkk뮕_MRS闬k-OL=+yZ54!/~qIIH)NP)/,\_}s9K.|x[&^½LS@xT߶?ϲe\{: /M>ǀ;o~~qOcGV|#&VD~_)Hk*GJ$GǠo͚5^x<糶9$Ʉkr7$n FWgl]\7\{躃^ y9ytN*x N?t@9\!Gu]|;᷿mm瞬Fcq#Fw}\.*"LiPy{Vm y.`{;ׯ7F:\-~>K$[j  \u Jyday127Mi%g%< uuDcFN>q9=v,3[ѡ>eDS7rA $b8g/MӉţt:#L`oɘլ{JBq9yKyG:z꫃KϸcR&XONr$0RDFWLB2L>Rsp$M[A{Wò4.kB4!trJx Ns>>O BBs{-XOKCyuӼΓ'8аﲯn д`w\=x 4 xo9ʊɌL܈VOFO@,0v[:s ʓn`[gw𾧒&@C0ԗi{ =Oظ{hjj^xU Ue4@4SX<ܛ:.:6 3nvg%=(m!6HuֱqF._Y+~H=ry4) Dw)dy>Bn4lB!%ۣ'ڎDey2vd< Rw;~4$&sOf ~\ ]D #sBV(/Dhkj?đBi)..U;EFb M\h|o_K`ƙGc;NEY O½FMW0S¢Yg9n.4Cs:GOW7FSk)t4z0Yp!uڇ$ڻij N#t[ FDCQ0` AJ[[줵3)+qb<"I1-+M,Eơ;4vn,<z{6ZǢVic:::{GPQ:4x)zţA\FR"č8MM{8vP#JR+F XHی]vDjHmitLNw1'9w,<)/uX8BYqeZ ԁ:֨ΰ%`;y4w:8tn#%:atkf9:p:]aMg2oǥ((TVLFݯ1i\>cÈ,E5+.,+"S^22M܄9W7tbU]^Fo!Ym)kZZg%I$$ aXZ hn0*]-R("{7|"НJ Ja{rU*g:^w ^_ )tۈD"Db!0 vTs ;PU섋) ziJےV-:e<8ɹ$@/$q3N4}C Z`*3;XLAםw4I4"t G(GZ2=oW/2WNq'DJVT_a NC}^6^ñpЅDp$&EBQN]pY=O0L`΀Tu\~+$Snf3sn;[\xC4 j P j9B'tyѸ"*0yc&H|`bX#RFf>p᩷YH;3/?Є2uM[BwN="l,x88>= #Fs[Bh\w=GjY1HȤųpinCymv|iU mq9蚆 adӈQb#F܈GPm4 ip,om$ ]Ѱ>$?HVo9GW?TCƂgv[7aav{CdD1Zd~Xh v|X2Z.&-)a 4zV{wuU3TYԅ>ƶCV}hžrR%շ|yq,t h(oULt݅;TPpg29=\b::KQ᜵A)_=uFk8D>5y" PG_#=#㰧<3*WDz_)NPZZo"fij;d˰֮oS+#xra&Ogl%pwG GjHH,ț[6`ɅP-Hzٓ?}D<["Wr2tDBn‘`^ۊGJ N)%H#ČR~W5yL&/є]@*(HFM']Z;6TfX<ʪwrNa+\G4 w{O$ YXن! @:ϿT{1)R*vRwI[(BV7*MF4hZwc()QR{΂HhMi6N HIu%? JO3NT%-NvF$"R!$E22]WI8f"49ؐ@M|@OS}+nDPxRB~hB`-:|ɋ~p DӚ/ڎ8vZPII5Y*4]=4X8)ǚ@?VUM t6PwP=}#G[n3`"J)e824_g[m0C Jk(G:? OGW]MoVR&~_EEH VzP@YS<ꗬ'_쫛J Rڵ*0P=Z<#QBH$EHgQzkݘpq5T&a9y4lO$]M0!/™+ݶhٖhvr^D|.bVkխw5F>qܓG4mkϙzJRǯ ))-u.gښGCYW9q@WkU*;'-E3K9ZT[83kGvLd(S<;{X9䩂D D~c"ܤhܴ7wE΋xP1Ww/4Sfs fDjvn?>O1RJJ#{X<?i!ɽ5Bι|aW7 i:fMڔEQy\E=zd,FqR`d&&0HB=,_@YHLMhX<\ߑ~^O\e'J3l+ TOˏ{a;M-&;Ӫ) !"44{bf y~4Gn"NBm64 $/mTu%+u[ihޛuK]i`ȩ}b.3&Rb'\I6`X#iً.tɘS8ܼ//mf<'Ͽ$9#ul\ Tf^GV NLi dB,) uh2^scN9.#qRa,Ǹ9e RZ6bZ:pܧ-J-FAa HJM,*cH 3sK3v1@8&䩪x`I=ɵ]SJup9xE<%\{8tݙvs-1Svf-j-da f~qo96Gmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???LL$??lAv,@z&?C?C?C??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3u%PNG  IHDRc IDATxw|UyB""  +bẖ{וսWqײ~]]k]eWׂ`NU0$H%mS<%$k<9gI'8aJv@4]c7uʙw 1>*hƗ/k^7/77,?n\;wD3t( D!{7Og+ ֗SoFT$Ifي;[|"±~]}^ !$$aϕ @N- ''i|e{ISM2S]WLј{ߏ.GIpLfz<!ddIFo|dgOPyWߗ}3%Zhe Mzx=>b9R_ US=bOĎ0tH@PK̙s|NUdgj" !!mN_h}`^xΗ`m !!H%}4'G}x<~"J=j c:*vi2d-k(ڿeSo6Ӆ͚rem$a} þ71 Kky!x=8\8F$! V7k}G"K$IFU4MA˜iՄfs0W{$4(>~H 2xd e:3!B`ݜNiN μeԛcse1a@Hd=lYr`1 c- KD"e6wlTA{K~rmG0R㞽)01i``(Adat{`k6-eٴ/"zh( i(aFN!=-?7%yZ_>$$.vK$+>tВi6nL`}3k|꥘6 &`5Yge=i LS4MF?`0nh,y%~_jLal0[oZ47GM]yCZfAp躎ahZ_xQB2M;zBB!t]'6$Ie/~o fu/}g- k >o1c}'kC5d;DpɂOR8M)>[Yx#}0JɃGƭm 4GuQ|:WX{:Kf$xEHM-cQ,yx'ߛ%n}`!pg6Cs;MoH}̮)xtCrOOt%m"%4|>%$Տdxd9uj$U}jlI~^R6&Mlkטd=]W?db:[9`F ;cPq{R jndlx*Kza74GBx$dYFe>?w>}i\e3n-3qs|M^51M&&a)leQ.Hՙ;Vכji*pp$L8~/;$ɶ\vlCAzjv:_R-?1iM` c#Son8.[UaȮ#vx{7]VYB;v ޭvpޤk !e}4@0\(\ [)@ȲЉv1Sc/O 3ЭB7tf=^i;icFvȞ,kdiq3Dj[cm6}=c}ʘ#E[7B<=M5I̜|CjX0jUL=9uԹh6 ]ؾg=BHl],O7,NC|kip_r")O/?[qXaFը.{ Bbˮձz8 ӍTm': QlMs ,Dϳ<`8?ģP iAm} @QÄ"u9B󶛌1ߚ=-ݑbLC>\^aa2۹Ĵl+Ov`&7ǖµnĠ1:LT7Z!$ ǡ^tC1Mm !z梘'-ǚ2&F2Jlm0ZY^`Ilųxae׷n"9ul+Äd1ZَZuo^Xfˊݑ%*ΐUu< sP::EyĠ%c;tAij{LCgͦgNCws`a5(AːǺmb fz tV??ONհ| )k/POX usFalCx nt}=Ba <0 fOUSP!5Lqv VjcȞq eϾ=pm,LDHRM|OV9Y$Ltö:h \!L 1B46 9zHʫzMu*j*2`%ߗWFi1;8tdl@54UwC$zdff:?Uf{޽{ٽ{JueʲZ﫠k'5ЇD_JF;N2lI!8yT6B@mMjT-B}2)++P8DVV7}a3ipoRjpRD\!|㇘IUmBZO$I`=.Ó@3CUèdh0XGyEe奔qLYEX[n.;1+պ@)7ղ$\6oLEE̛7#AVN6J+yyx<~tMa>(UU Äa `gGoc DL:y|6BHP/{zS Kx-ԵX={ [k}B,Ov )*EQزe YYYq Cm's '/t'M駟i_Onnn^]jL{W_76xkCUP8״ufyfB<:-Q\\ڵk( 7p+V$X^cm,RzȺNu.C'`5Wٍ*̙Ò%K~=͆uBH5R'>meYcIK:l.Ddnm;ƒi%'xSe H A5"j`&ițZ&17Q,\riӦ#k[08&է?%+!jT,(qf3Yúu5jTo?bl…^H>}HIIAu^}Uٸq#]{2qK?kܥiae~t,DEGݠ'5q9^Xw"qׯgN$!5*2ɓy6l0FMvv6P}iv]&<//4뺡%FdZY暫uôm.ʙw{BkޛQZZ_| 0+؜whXԄi)>o'Br7JQ0‘zԣa+ܥjyZp0Cpf6]̙31 ?7d?zoذus'? 't߫|QK$![Y 51LUS\D 5DD ڂ*havғ9I%3KC(??N?*ҕ,ZtU~7lW]`~  &!E6K1B`QV?E#%}V|'wQZ-k),op gSk>IvƎk=W]<ߌ9pci=XSN! }9eEqv<LH_UZN/lX5;ͰE}T~Ih5Ö-[Pf&TWOr/ɹ]ƧoY  1gK݁z+,\~ᅻ;T|8ܝ[]gGth!;&/3}:SLq꿸M;ay_tMwo48f %ל7ņl> 7c@(JXGvi˖-C_{?Y83]=t?F7@ n,EQ4'^d>38ߧvP0Mob@rT[_i1tww@ ? z.;j?Őzط^[禮/4eތےϳ/$ٚrcBQE'ꪶ@)8g {;ydzϞ7;4[҉窙wI:6Ƕ@_IAQÇ_*DŽX"E S^]BXGRw (am݌pLL<νѦ-%?=y;7o^RϺEyT,ζ>iY]R'gks6|C޶ϓK<֮Ėp ]p/[֨Lk׮wm+;3XJJDdQ~d(;g<><?^هdeÆm_ 2`ѢE̚5:NnϮccìY6m;qqg2 w=}4';:uAkaas#ڤ<"Q԰?\٪p⁕<8=9BҥKinSA?&iڊ$VI"FoF $)j½y-{xQSPP&*(ʣgLϚ')q#AMI{;xxND$J/f:ܣ1_.9<9eMj @>0bDs2NTmߗV>kq]vwgOp뭉 ۘJ0dY yOzEyLZMY~wULfK;@[E$IfE;+tߡRWZŭE]h'*`-xfP][F8R # şG<;zRG74kAWIOOr8DP_?jʶQB" ߗ,yo3-AR(Zk`pݰ9f-fEb49D-bڵy\}u\u*TZ6ïA=ȲYpu^RydMIQon@c5WW}-x|uQ|]v{W_j***IMeKKנjYr#;cq.kut]Tma/1 ?a׶M;lkg2n`M9b$I]/f򗿤QF\8iu5־`u=9UΧk^YDC+ېMؽ_y{,#<⋔ү_?y䑸# D"0(OWuv7n %̎3Xn5?hS_ۊ!wxF;9Hʼnwc\:'TktwD3iEkBռ~W=IzCNzj=Lw)GAzj6R/iVO@e!%; ẋ;B{ΑdE;t<}3CZJ6*v4+|a7ult=BWD%8_HݱT/[w)΀.xAdn3aTj$ ַU-t.hfێ4M*t_*^qDm-4yͤY%Qtcv-%tf0 ֖{ۊJ1ş59rq<.͑IÏV5ftxR QLN?4:h}$OBSt{πFs7K̓ot{L8i&apӭe[@u=$Ii*pc˽`x$/|lk}?rs渋thQx<`ǹE"AZCuݲfL\Br2:zhzxN>~*a`:Nx-$]p$H0TK(\''6TE]IaW]|GMr \pup<`6TBzZKDZBUZyҪƎD4zPal-\a,]|D9Lt_=@] H ziQwŅcWkmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???CC$?? AMr:@@4@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4PNG  IHDRcIDATxyTս?眚zfFhh8T@D]qȍ FWx_Os] ϛĄ]/H Kpdh4H7 MCuugz@gC:uٿۿo#:&`԰+)vr#Iv5̱1&ȫ D4嬼믾bW9NG1&,hh,-as"IvDADڻsVʫtEk(R, v8(HBX`˙eY: ~!)C%vQu US1躆k$sZR>HP؅P1t7ξ}Gw" :zL8bNM1 ;N] mNTME@H!TMAՔ$J7t !Br@ȇ)+œ GF<]g =_XdA@zp:ۜ |jT@I $ :e̘] ɁkL#C.Gz<"C,YqE\U}=v3"Q {Ӟj *i! M.9Q碹`G ؋σdHPt]#%o2@!4O(G`B$趴~UFV()$ڒ|~@Ћ1MYY97ν'\SLjv j N)qD{*46]j>0lAQT@oσ颬UpT<:jR5ЛR^]).*1x5hcG-`%Qu*( r?e3g\TMEQD$o)wŪ*A@4c$1"]PTPoY^_.W9$zDĒjhl=~wVuЃ/ЍfʊgclZ\4~z9:hta/(+F^ȕ렬!]u]:863t&$  w 6'ECD!L?gm{:Ug G6ΗvK! yBa?.g)_[ݬl!y*TLbfB~ObfndJKGwfaa<_3~ino0xaR]^hܘ߽}_xm~a?ÇT򕻞`"aO` SMGW9-!#Q84ll=2e}`bϓV_9<}<IGwݍx>r;G1xzxr!tYYS%$in@K0CBMbu&]yMNKwާ@SL$!?xy7ٳKno^_'BCYͼ5ObV?Cb"9q%@5cD#DrDVSs=P?y2"քa 1^}F=974] Oo2iP`(կlӈ_7Xq Kuu5o1A1놙pƒbr1Tqb_3gbu P`(@(W_7R ;t]w;0bZZZxYl٠0=vj_,HN EDN)ZsUhAzwgb)>3X37:FYY۷oXj/>F TGZ:Zmۄ0rli7p~w5vPG8C8k̙3^ lٲA}@F>?_s{R:ydNx7EQ0bWMWQun}:g嚦BbPpäK.eᴵq2sL^u?PQq'Hb @ck_ڗt5kXbo9g6L$x1ͥijUUG?ͺLz%6q8a{=^x>/^\whx%矧_[l۶P?n8˱-E8ycYiN¾zhƮ]R>s:G?7Du#usuMcdAxihhСCl~fvɼy:4Ċ,DI/=̕Ww7dT<ϢEPU5pt:9{69ݳg$ ͡D͟ٷon;I8Q6m… ygθzw-} Yx5EHѭ}h;S<*o6k׮EuE!ǼѣG~r5l, N:Nv؁fVZ?̬Y,'hB,N="%kb5j*2{ʭO;gK1xqjjj8|0, c[( ~򓟤\իWdrJyzzzxb=Ӽ)<쳬]1cĎ^ xbm#c{޴&5`=RMihMsV8Л8`p̙i߿3f M޴iZy뭷8rƍ{);~_%52aG8(4??qbIl9FM'D̙8pr^5 ^| yH0FH/$vYfMRUwy睬ٶ?҈&M yk#5m{~~#rϟWS:ZZiK,ᮻB4TU%GODPxIƍYnsbGs躆]`Nfz8p`p8L(BeTUqs ٸ1$ V_,QΜ9ïk~aN8qOGs#F8s-QϓNT4QL1cƀ~SNeԩL4_5PVs;３+W٧?S|<@'ׯp&bݦO?C nKW^љuvƍ3ʕ+-[L0GaͼHSGyH>hjjB1 uֱ{@ ͇YqQ'FAԳ3YDl- j4fsxIǁHںu+:t(/vfʥ!:hM6􎃔_\O5K_cǎMgϞo~[b[l{6m,L0eL*h9EoذVn7#F`ԩvmTTT0y/3dn7{СCI/Ǐ@u6o<ߧ?"g N͊Pr94gyz^/-2-ZĂ [˘0a€y饗hjja#tAb Eǿ =jz Z)ֿiX~=>};v_G-c…3&6l@]]^7 ,EA=OX:$^_$@">A)jN>+`ݺuիټy3>}V]];vc83曩m۶؜kl',Nލ='".d<&sQmMfxgr~kGĉ<1]**یmrxk#gtvv2zV]m}ug$,p\,A=dr'jƉr… B >iӦ1vXΞ= f/bjJ 'N`yΝnʤI_GH.$rD3g9lYz5dB^\?>]]]̟??)3WZ KKK >O>fς >c3qQVVO4+pz!ZZZx<۷^\r5kTUUαc#xҴw_'NN{{߭h\20<ON9oTVVRSSCII 7}#:ytuu܌(=:~)cy"ԀV<O󻻻q۸Ru ̓wbڵ7Dq03aPq\HΞ=Kee%=EEE'Z[jkxq8xn%bi>2={k.>Sʘqzq|Ix>e{ši?~o\Bc s.-z{ mc\-`Q촄sXpZ[qڐJ`.F\DXȘnQ8,Xd%c1xׁ[1V?9PzPm1xA P >Fbc'K#@̛r]XOXm5ճdhٽ{OڤAêdh\6$Id˖N5x`ɒih\ha)ԛBv/bmY-* Vs2B!Yuwu)_`7XɓG3rd)&RTdo†ф^qΜۜ/R_߆'@ssveG@1P 49Cn|mN,ϓ%qŌ%fc1x,2EXK<c"c,Xd%c1x,2EXK<c"c,Xd%c1x,2EXK<c"c,Xd%c1x,2Rs-IENDB`move=1000;blend=1000;3DR6A1| ?1UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW /ij5?MOM3A_ZB oB֪ZSUUTU/ Z椪֡BkU5WSLU_j֡/PHHHHHHHHHHHHHHKW Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUI ~binding site for residue edo a 172ac2q 1vbinding site for residue edo a 174ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???``$??G,@@ݤ;@?\?\?\??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 59PNG  IHDRc IDATxy|\u?23$-,ף$g|̼y-`NE0gE氒/4VyI%9Ya`8ύ oIB @{fhtz$I,{yŨ BBha*$H!a P&0bx3p(ȒȲ9箼Uq*R]AX i3~ zx7!)!IPO\[khZ+ GjvSFu؟q&gF88@dd`XxB a p$$WFGW/ms71TKNvA_o[JXQp?B8V{ j:uGM͓K"a! 95$a`9JpȲ$I  St]K20$$]<-:|MC-:Np؛C5]jƴB<8HoU8#ckh10 7 bJB _O{Jcw5)"8vR <μ6RMM !!8x2sZ^<&bj'M"0 `}^|Qꋕ!y}?ҞKP_$9`/wǏnhd{B¤yfG j_4iK``"8oe}c<񦥁t=nb:myt[R09d&,o|>#cȲ* C9RCI-AЉiQ1ZG0|?u5ւ:Ґ^kdDt|iixPlDY뷈Igq8'IRԾ-EHC3 fYYQ߭y;Fj{,wEynJBdxOhGe@Пro0L;,w}ׁq֒eG"!SĒٗ?$1hQ_,Cu&I!˝k=`y3m"A81n<\jV8փ<89fPQ:19 2fס3:;HlT8ϧ5Smԇa Ix\xֱَ}S{PQ#0m6ʩ(nm9<7Iu8 X@9h26AcHk5nF'Ō;cQ?R"?$j~w,JkbT$=HDwOGUʅ֗zK_GejʖFQTTż Oa^yeFXւ{:pn0#҆0 tQY1-ᨊIRs$fË}G^eߑWӞ{ȈL\ɜq>cVPG~^W^r#<axr=LX ւ݁Nz-Qi:fٌ,)f.RFV:)*?̈́yyi h"ȌcYvZ$e6V(nYa% +1_rK0 N08~kxʣ n|Yj\3ؚγxh[}U'8{~BtcL=;L: 3xrvB8/!n8 ˊ;-HFQTs,*l챊 eX(o涺>]uc*HYxMXnO[;Ӛ#,mwЭZr4rHEx"* 2r-u2ܕYv<؉kH;N5>27a弄FA>%k!;)8uz4?2*J2dY&6#aCE ˝$Bf-uS+4tBzM`{yVKS()`ʸ{n`v6HBBKrӋgc'SJ$ ^۵UK>eIUrKbRRvzl+k|H{GzL$tsW"I2'@d+)l~p1Yrd]d(KK-_~dvhl@UM_ǒye#d8w'RoaWd&$Ibߑ⾦LL؎*g$;)% osdXvbAΰFY2#INtʊDz|5;H)̑UƇX=~1Ps;;p$؎&Q/q@oI&[1j/])/S[n7fjil0 .\p-=bx&ҵBS=nmv'@Kqc BƞǭÉ麆"R~)) KheTB􄺘0j6.͟a8tb;X fOZ. .Zthh`%T;/kF#l̵TcYf˕9D*#wf\a.N+3(jZh8|b '1 F[kiju.^ f$I֎23H]wa(0t>Y~!?iFׁ_ _w6z\Kǰfɧγ!HIa՘yןBF_$ Aa^5Os{;<8 uCC74%s&aˎ҅I#_Јٶζ$`j4=F ">z! <9ds؅_L]_fϻ9RCyIS˞ IE7dnj09 g[khh!fK-Glf8m^Y\\j.5GS[-/o3KZh>CI#xFB>3L/FU\4p`f&^Iϸ3#/Qnj>>hy(iLU?%1s?m%PUKZjظΌ\' cE%$q!n5+ 32gxJ͐L(HyT`¨hNIpn[khluIZ O$LB\,ܪˍKuk֘ߤ=>i*⾇oM{^b:#D{]|Z[OkJ;TVLwM90ݼq\.Kx\fqߗnUcJ1odaçFOaXHr:NNIrݓij_7vLX8=KNKaj~&x(C_(oHbXO"}\& DF^GjvvƶӖ}+k*y'/ZM`&iS$p֔!-[4~~R2x3"3h,qԑi`+W&T߯T[T&Yii?Ē_hM;Bih9I{WcB!׿nXi_/lky}fGb}gOt'@kgpї=ߠ,!Yk:mjDR\0ej{,Z oGn5T +^#i_Y4NOlCU]JIA_WxfO]׭l.Yv3w6_3V+°TW, c߾}Z뮻Ƿb=?YF@PyEy`6nC 2ik:|m k!OLK,od׮]BԴOu=?0֭z({;y/2E?A?`5N V dZk3>Lb)1Ʋ mzVZ;9s/{v9Ba57n''[цwprW$|Jc IS?ɕ 'tNQpQ?\敋RQ-3>ҽWVL/zbK њrQS֬Yo䦛_'O6{lƌ6nC=sl̙ ̅wNTVL`: .e xbf>#w~g_q/Rq-9aÆRP5O^(+^S䕊¼21:yϭX||'Y [ظ;C0Ӑ|+LjnXԩS79~rmܘ|x'?~<&MJ|)T[I]x"4p!0i-B:9vzOjZ#:hO,'ٲe;c׮Ep[n]'Ǐ3g _3H!ΤjA+6˾v3CS) ɸTv'_@Ǚ5kOrm8̨$ǔTTTdnKthjtdA+Ic-dTdv%r4@s^;F_憵߶K'acذ(f̬! dI6;&aExcr[cw0kHݼ$veOKSx~ٳ4G~Loyůx? P1LEq9dxǏەM 5J7نm>z4U%%u)fWWDEşqF_8$үY#]N%K7$r0|3|>(--%??EQ(P[ѕii7M[`q4G<>C\r(o-) 2nC$bObTuf$˄BnOl㝨2mO~ӧsRHz /|+ LaJ7^}<-/_g `*٧UvEqy #L.Nv#b7V:s=ps"UV߻?kr+qFrKOD0<-VXn\.Eh -f7v(*ÏP==C2}4" aV7|e֬Yl߾˗s7:WA¬ʥ^ ~;>O|"*믿&{ΌSUVLǒjigTd_C |HgӦM_,O.\{k֬_`^*EeUn~<6I+,5_wsLuDretJWW*Fxl,y9H ,iaX YGa:-N6|kJUIQeLlŃd/_-[O|v?[E:"s/%[p>;0w\.Y/ٗ1l:VRKIDAT[},u󦬴uW^\9,8t4[p$3ko.FEyy9x^[oC7tBQ^y(!EG̙_{YnJZdw*Sn ]/9ZG#(RO4Xv-wܑG?Q-[~o&͛vBZPlݡK}4/ o}H@lٲ;n|)9sL߿_.Ճq.TkDx-a@!̎yaɬga IzUr~se}_:k׮{1S{V4iŠ\;ngekʸEdsp||+oرcN.ah㡻|b椏0yFϛ  FU]0/|Q0"rLf3ðL'd:]z#c N."'ԛf;9hn<$$> ؼy3%N$fM> YRxѯ|_₹WEU\,L[~_G_xK;ˡ--1%H:MmQ=C @rhJeDpz>xrFftdVmECC1fNm~~o}]⡹4%#(+I b{m6Έ VZIPܮ; `'N;+ a:[il=I| pƸTP7.͈J;y9{m VtY­zrX2>\y*GNfꔙ< 8r̙ѣGٶm\s f:dP1l{ة2K,eÆf4=L0ԍL;#HH |gVK0箌mtN$<̙rQoݻ||f護ʏ.[ƍO}*{ EqG=\(Q_40Ӑdᗙ?m5 iB[o'oJ((JGZi% q9@hsfDNn#$?/'sۗ.|ě8ztCD'+aueΝ >Յ7`D=Ը޳[,/vcð:o}[7FV.ڈ!t4Cȷe}}^6gCTc J97+UqEasbe]qxEQ=G ❣qeRTk߸]nTW_O~ v54nbP;7sdZdy_̆vWkHVWd֎܅!+(i4MYg)ʻ5}]݆!Pb݁X@= zxe|tin?ǝMO~;8fԜI1G4Ua4f ˾}^{-VH1m aο`%NWaXF~ +\8(yN3%CJ=aC)􄊲K=7W74ˏ` CG$9d;Hpܮl$::[y駩xQ>;xrIcN?f;:5ia,YRӼ} cw{vNlfbP sE ahȲ .$B`{=ȒP~YLM%#3#'f5 pss B@gWKi4V/ٲ $wEV26dBvy9Vw?<΀͚Ch l= x`0qG~NqQɠ kAz]׬- ''+ ھ__3N:I:v*.FHA~SB""\:F$d˦I/p.N3iFn=]{D '#86n:Yy^b2[Bzp8HX :K2>n6`zՒdo'q8K㸙щTV`h8õk XBcF)o-YLQ˝.QD-NZk nes6 h% NP8auC~:Za9 _Xnڻٶ <\%T}xx0 .kjL]wI*4v~Ȳt]L1ZOerƑ=ilO8:|t;uw?7{ !kmq3#LrUֱﾛ]̿ 'ظ; Eݎd ΖK^+mjllɌ$}):|-B~V,.cP7\Kf\ !?o-9v_*JQl9D&̽2Z+ pKUӜm92 VK[Y|mhzFwUM\<$>}};Kz~bL}՝P’swTՅ[4f^5BY(pϝw#8`*@bxuvgR=dyr6.z>j69^ vuox~+ʼnSW{x^Nc\ Sx: 4#L]QTp3{ v4Y:)/C]xIcĚԌ֎ ռHvD[JiND~wX )P'4}C_`|$ Snf CNw{G O_3,mfw,+3w Ik[;Ԗz#|߈liz%7ͅI~ +ʫʗeFUQt چCԞ=LYؘpfhQf(LzbTfj- @TMa^u@6LAjL PQ:Jˑd=4I)`^&18nͷho3.eڄ%ȒK; XIYID[krʑ1 SCvjJBdYAk16βHQ~9%3MGΥ0[k:Sc+DS[-o|މG ')"'Ÿ/SǟgR P8H0M(6<2zD096i'f$! C7m 8t3zڜJaf&ySmc nh)LŒ3mR@"d|_zu6P\0"mRKo5.$';9Op֓u9ݪO2#7YnSf$_ cefh̊-@( 3,TD-X~Y.x .?_0@EKGvaeMGI#<֗(d1~L=y#2_،tBcV,]I6 B~n19: 3MU>ъuG6yˆJzwd3]o=n{NV]tåBA!=`f&蠴hh!IJzm]0u ţ$_ ƎJt\m9!+ι39GQqO]MYo[r.@eJ$,Ov: -) dY+lj;Mq~yQg%0t^atz^ 'j _*T[!dz4 ~)VK*\ꛏ{8o楔=5L3Dl m8@]K350M#ԴGJTVL#B'=74mr㒨(k&7²_IUp,5mq#g8%^;ѫ7Ӝ?3Y=2nZfeSj!tClcܩtb$QY1#&x_1-vmޜ\jV8FU+0r#aOHdʲ&fΏ" ɑ*aifeX ڠt #-v"5sQ~9y]E Id\2i^(e&k<ɨ۩ ?X:Ӧ7$7Kg̺| u҂CPjxPxȺajN5$i:KvV>y\:ع`LAP I(B1sѴS4 EVQ'@ ݕF8v k4sK[P ˄Toګ1{a펏h %p(/ٞfV/_n`wod6M \;|BޜB$Ibșؤߦ4sktk+oOXzߒ/!e/ds1A C M/&o͚@r*.vԏw[9Eh甡X 9ǀSSq{M%e.^BO@@`^Njo=X[9q9Ә00 8YQ-Jj MuGx 4-I~E27h9<1o>(HL2RL[%KotY;oN,<y]##]x#fkaFS[~3#I1 o5#s:䑐`쨉AL^-zHkT['D fL<`D8 J0? OYXF2ؾpZGhtClÂ:'dl{cܶgleU /IKKsAbة6fN~\C_$TR]蚞n}&qLtj  j= ζ1GU>۵Nh>TQfC.8@L9|1ǥxu ! Owk>Tp ONIH\:c@$Cj>!BS^R$zxHÏaBsZ⣏啣.3iJy9#mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???DD$??S?lg ;@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6PNG  IHDRcIDATx{T՝?Sw~(44QP!ax5+$z3>H]rWLhqܬ<\&N܌r *8!Ah>u~WWnEu:}f ӷѹJP#( hBFJ 2J]L (([#O--Lh@KYB B J$FD"<زJes.Ò)-,ĴRVʎ 2 ^ÇBCF9y$m_X@Y<H[L[v-HL]+syx >G uMMDj3H JcƼ+%.]i;7}Ra I gUU:NE"{nk#AH)rb\,% +G6é_ _!д?89dx2J"8ױom`e~~M>HykkW]CDD2sʄii0 rنa8.W6u3H,F{ihB:NeMNرv5Rƥx* {!z$o $[\h~tQ9&G~Eu!UatJ$HJ>AD}quk:L7iWK[\^^/u-J¸(*i-d3nSf1'ʸ˸muV,pa.uuFY<f멪C=RWS{'tGN2o֒RWhS J8o;HݥZ(\qPUQ#uq>hYxFgλI(hGO|́;J]S(X`%S Gzhimd?jPO̟ OD?] *bgY83ax/GO4YRR<׬:Jbx/-'xi|eQG=vb@r:B*^b(-Mk|HmA| -RD{՟@5xXB R{Wkf`)\ઍy%'?)ȵ@z o~X"&~ZA?^xgw:b7,?j[owQ_K~`5p{;&`L-VЄDZCߝ l޼9va6.1 Q2TL+E,;U7yx衇F{?]x\s5G?RVl/Zsl{O[(KK@!,ꪦ;IgO@jCb3T>.R8]]]|gӦM1t׮]L4|{>zeFsE&똆T(;nN`4-~fG-ei #7h$ &# M61sLy#LW_}oۃիI$l|!m-tc )$T]i)hGMB Hlr;my ?1!D~l,?R#7O<ܣ^ء݃Ngg6 Z;i?y'{cM!4:dRc'di ґ[4GcL{97l#jH@<ަ!J{!FO g޽޽9v=cacǧ dzt !, x7o L<xg R׿uYw(d?^/NܭX 0}t{7)\2EquqA4-l>ecK/y =cŊ[VrJYw\rʒ?l9$UdCt O>aϞoQ3{lvv'NTUԣ o?JEKB4'ϓ笱<?(z9 3/$GO49l  j\:f1|%Hٰa>hQh: hF_fQeE-w$hJ2_=I8X躁{yVbڵ۷k`4DObY5U4b μ{pz2>.麁k. 477o|hei)T!t*ut:F_Yg,+ZŐ)2mW!!r֍&>乏>(mmmlٲtI$S 0@z8sg^ā.j9l BÔ re˳[XԠ>S߿x'$QOBO8c9{#{mg51 $b9E:CMwVΣu=ҼpcV _́#x)[ǒ%K[;w.k׮u^i"TK< Vq(uUӐ@o$:$y:˶f[`RDh7r咡z4ߖ-!D ^({9 ;v`ǎ\~~hXM&)".b{%L%HGev$@4Z^ ݃{^t1 j}h_S9ע 0ȭ!oΝCo*RSSS]X/Bx@C$e0t VQiۣ=)k[nK/i-'FFe qo_{mH$_/ZVS`tIIF"S"B%3'+nsEKk{?:B$zx"w4<2wx 5kGkhB~fM'8@Z>Zv޴iKk|$m'lfy^o;e1g&muYJu-4u%˟L,+i%Z?0VǦK$SI7]O"i OzP\vL?eE!߇)!efߥE&TnG%ْXlW n' ;/D:]ZOwΜ~nLȼo|ᒛi9d[vUKyu9XC3EL/Q#w$1?΁(Qs0Nz}-nf\hD^G"z_)-H!%TѢkmR.?t3D2RT[b8b;k#,Lfӈ̫35-@9V'ͻnc˟3 _tHg3T%>yFbZ)/Ff"tleR 1vE})l9߅7/k "eQ$S1b^gHd +hpJ%9ui'&G:Y.%YO+0|K=8n}dPcB<T܎UߚXxg˙0@iǻ/`lAJ,GHv3n=­_^K8K;qcOEdI smidYVw^@ZᜆKjH.{ v1~aY)\:űHi/>>o_f-2hOlce-'1ķs\`x7I35<넴<ꚴ!Qpc{.{34V3`ғvI5>ļћ״y}/H80A;@r9aQʫ APp|{IENDB`move=1000;blend=1000;3DR6<1| ?1UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW /ij5?MOM3A_ZB oB֪ZSUUTU/ Z j֫Zjgj5%53RTԟԕ#B_֡Wf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUW~binding site for residue edo a 172ac2q 1vbinding site for residue edo a 174ac61met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???==$??-@|??}?}?}??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7 PNG  IHDRcIDATx{xT?sMf" jZ. pJcJj+v>.-u+*T]D, XEpp+%(I$!I~yL2LO̙y;3}{;@ m$])nx$FG)nx$FG)nx$FG)nx$FGsDY@ƒm>ހ<~2"oKO C5~侬"ږ&p"I(C=-G@+$E?܊ʦhxDPYaDN[04@D.* R<1åQ H :=QOCoԉLӐӰ TlպPOpOXM5V AᅓTՔT#Г^7ԇ4kJxmsDRbuKG&dg`a㰧v&FCmw>R = غo7״AL|c )f#j ...tj\([^4Hﾑ ## LqqU]RԺ+qyo`3vxTuȓbm7$EGqWvO7Q#Ը*xRRTVFFQݯ2ILg۶/JEd;h hOZʰ'&eKn݊ b>h@!uY2F!˖->uib^Tt*h XV EEEX,4MCitPo9u-j)Z;KYrrrvTUmץ^?\to:~%`ׁ,%TMat WxrGs? feeѻwoRSS9y$7>QRR1.X,V7,% cp"!f{KR,w@|' @^>'xVmz-B?1]Qϟϙ3gZՒXf{~;4U C(jUUPЫPQ5ȴj, g׵z=ѥC6gׯ.WC/fE!..+Wjs4ẢD4Dےhaԩ^)iP)6zWv!]K< %%gE$1FEff&+VX;ټys?.(2фM/xm:O7 SG?[2_ qV=/.[ Y8[s3`1ׂx:`ѢE,]ŋ7ʳyf~< "\SWN{r) #W[C5Ĵٍپ-s=lM@۷ogÆ ,[\Ut~cdž8wyE{DRՉ($S{9yӐ:xk|v_ `]6ˑ#G0<3<Fܣ04 K%fL:gyYfEV"-- ɄtRSSޜNgxKNNf޼y~lzz`K!Ͼ2HhOlI_tىٻرΝ;2e?|g8q"+WdӦM}UM ocͺ]}g-ev;cW۷oos޽{2aVXrH*+ Э~ѡbۈ`Æ 881cN) e0QYYsU :Q?]P<`w#OW/e>|5kx ]\)SzC-wH0,]?:@\'\]͟7*n5bNnΝ:@,Xu?~>9]eTהRjQd۶m\(;*T4U if혌&F hUF?kF*z$!ыc}/!ƛ?mET4K2;-(Z\w ߜ=DyyJNR\ uWj O>f{݌H]Þ~F#!PԶ !in)yG\\(?Mq\(;,ܕ$RXxFAUtnK1 n5cŖ-p~GL婦Gʵ$">.EBUEnmn`4Wf+hIǚMLFspןvȗny<O/ }ɷhʪqOtS$ў9Kp;]eV_-fFB3b4CQK/ݢoR>{uH ,+ Q`2ܗt{bs`6Yӆgy$ؓةHNRb$ؒ0`e2)>_t؏n)z7^7!ыkRIuݖīmdb`㓱%]eYl[H hjݕԺд`]nF^afN_wJnrf֩t^y{߅9t p+n#RX0W),a/wS5.`_t-<֭㫯j5_~Q\' (,u_mC`u = T{<jTPE۪cǎ|L<|EG? egj`rەp PױyIcsCX3o/mx˶_t_CIYFʭЙup硇|'|'m:&(>}{2~ó:s0,^ur-œdlڴܖf+\B~Q~-XJ@xn͸gwV&*<8Τ[gĉ 6 M%)) ]vm[u~"O@|.weZ.'SF @Qt deeq7rYrss9{,gΜa<l޼cǎ/sX:xwST?@Q(j@Kum}{e2x`_<8m=Pӿ`,p %d:=Fu]GNN|M%8~8O>$;w INN=yȑ#),, V'յ5!B;pM[ sp4UU/xC_G挌 l6'N`̘18p ~aÆ&{/g09 W\,Y‘]ߋ?ࡤ JhT^FMRЁ0>(>3,f3s:`,Xo)--&Q\ =Sx=T::y#gTkIPN[Ç1F:?fn HMM#/ifΎ?0|u&Bipl44 9>|IZK 6PK+\Q1Yݻ7;w$;;;pF $(CŸeddq64'Ňi4h4ՍW$ Ϩ!ӱZlh㫡UŊqM1yeEZv2Lnk~m-[?ϰó8B}YN'UUUa-1C44M !.lWرc tڽ{wt%gIJAbBO7/m;Z (Jp}իQ[8D{*Tɘf6}J׌~CeMc1[9ySގ`-H)!`ciek+F}:}w>i*&gZk֬ {]ߛZH%hOnKd4uEcϐ!C?~mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo b 172ac11~binding site for residue edo b 173ac3(UW 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES12BL1A. .CE (֪*(MjQD֪UWIEFZ֢ZR?UW'A?"""$?vbinding site for residue azi a1173ac1qs1vbinding site for residue azi a1174ac21~binding site for residue gol a1175ac3Ixx 1vbinding site for residue gol a1176ac4Ux1~binding site for residue gol a1177ac5.DSU 1vbinding site for residue gol a1178ac6^1vbinding site for residue so4 a1179ac7]b1met->mse selenomethionine MOD_RESuu1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES13DR6B19  D D E֪ ZZEQZE֪ ZZEQZ Bf I*"""""I$I$"!B$IUAUUDDI"*"$$DI$I""""#$!UUUUDDDDEUUUTDI$I$DB"I$"""*$DUUTDI$I$I$DDDDG vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1vbinding site for residue edo c 172ac4YY1binding site for residue gol c 2690ac7HJ 1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???0K; ?3ynca; chain: a, b, c; ec: 2.3.1.-; engineered: yes3DR63dr6C 1 2 1 C"Bu?Bl??L?cab??????? 5AAAHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW51aap    ff, fBfffffffffcff ff fff fffcfff ,ffff ff , ffffffffff$)bbfn    ff fffffffffffff ff ffff  fffcBfff , ffff, ff fffffffccQm    f ffffffffffff ff ffff fffffffBfff fffff  ff fffffffffaaedo`Xedo1,2-ethanediolaaedo2`Xedo1,2-ethanediolaaedo3`s_expr> Xedo1,2-ethanediolbbedo`lete|appXedo1,2-ethanediolbbedo2` Xedo1,2-ethanediolccedo`Xedo1,2-ethanediolccgolXgol 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_ala _mse    Ethr   Eile" !# Earg #"$&-#%$#'&(')(*)+,**. 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    f f f      f         f     f f    c    B          f f f  ,      f f            f f ,            f f            f f f f f f f f     f                    f f f f f f f f f                 f f       f f           f f f      f         f f f f f f f        B          f f f        f f           f f f             f f            f f f f f f f f f #binding site for residue edo a 172ac20FOp#binding site for residue edo a 172qac2F#binding site for residue edo a 174ac6F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine uuMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp#binding site for residue edo b 172ac1F#binding site for residue edo b 173(ac30F+B#binding site for residue edo b 173UWac3F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine uuMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp#binding site for residue edo c 172YYac4F$binding site for residue gol c 2690ac7 F$binding site for residue gol c 2690HJac7 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a a a a 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 a a a a a a a a a a a a a a a a 4 4 4 4 4 a a a a a a a a 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 a a a a a a a 7 7 7 7 7 7 7 7 7 7 7 a a a a a a a a a a a a a a a a a a a a a a a b b b b 8 8 8 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 b b b b b b b b b b b b b b b b 11 11 11 11 11 b b b b b b b b 12 12 12 12 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 b b b b b b b 14 14 14 14 14 14 14 14 14 14 14 b b b b b b b b b b b b b b b b b b b b b b b c c c c 15 15 15 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 c c c c c c c c c c c c c c c c 18 18 18 18 18 c c c c c c c c 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 c c c c c c c 20 20 20 20 20 20 20 20 20 20 c c c c c c c c c c c c c c c c c c c c c c c0K; ?3ynca; chain: a, b, c; ec: 2.3.1.-; engineered: yes3DR6B13dr6C 1 2 1 C"Bu?Bl??L?cab??????? 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