B3.6-1h/data/swissprot/ 3DR3.pdb3DR3A_ConSurf_DB_pipe.pdb 2G17.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Structure Of Idp00107, A Potential N-Acetyl-Gamma- Glutamylphosphate Reductase From Shigella Flexneri[/h3] [p]A.U.Singer, T.Skarina, O.Onopriyenko, A.M.Edwards, W.F.Anderson, A.Savchenko, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3DR3" target="blank"]3DR3[/a] [small](deposited on 10-JUL-08)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Consurf" --] [a name="5" href="#_"]Consurf[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Homolog superposition" --] [a name="6" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  2G17.pdb3DR3 a_3DR3B13DR3A_ConSurf_DB_pipe.pdb3DR3B1  2G173csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iￌ JzyBJG?WO ,U7,w`ٲJnv;6`zRH,; [*+[($ ByKOZzgj{&A) ozaiյ9%L_x?$դx.+uGAr+= 䋷+䦣1~byM*m;};W?GS}&"j"gs HH8s\BO#>Lܺ4b"m9`x{?4-[v`/DVb10n:uj~4]SFnza4дc7:qu2p" )lg`60%}X6U"t=x0$@ ,Fai36ق4wi$Tj5Z7dOYǝJdg}Ir5@,ynk"z$ >!,(!H@v1t $, BӜ8qIgؒɘ&s8!HIƠc(УBM$?hbrNr!⋐,M9OZTD`"h8< 9 фĠy*l'ˁٔ& a(x[8/t72kW CdwF]!,c1Y*lz 13-F8_<S_l0ĉӻؘ`M+p^conF_7&Fhdj?a,f BIq{RHQՆF<Ø%.$$8E!7 J-FT,s;*@'D]_.!1mxiӡ306tMUUT0L"d|)˨;i΋Gws@ܕc{p! 4AyZ3: H! dN?ɕj6(LIEt\j9IٌH~ZRݖ +Dp"+W6)4塚s>YZ͏xŅC%ZLf{ 019°%*Qja]$n_J \3!1))l3Y*|ޕiIYxVEUhP(]5 VpkJJ򵸸|w-SclA#)>qȀ$CFUr ==ٔTAk^^d58xLw|QGKozyZӎ|[ nJB(۴@RH T g8sWt1S/q"#<..Tڄꋁ@/A&M{^ߜzӈLi֟wդ8f-~ Er bn~?ØrLS/ hgҙm"ϝ`Z sθFFjr`=gŷcsR*q%w! 8Cpb0@ix arQF!UE<=G*Ym 4Kg0,rbȟGv*`0$I]xy]@k4.ń3{jU>{`*4`٧Z+#1+J?\-^Ӝ(K+O#L8(aD" dZ߀-+Y :&[ʽgcң/ݼ}3ts#LDffe8jz] ǑN8{ ׳J$]bԣƋXZ+}9spe `Hvu0,:0W~gvwr̮nǯl]3y.XNG^IIo#ѣ#)~{o+q6G @?31lJν9(19LjB?{w Jh$;Yy"cV՗*%_@0} /C b*ߟ)>q6fKKqLZYqŨj\#+juZm]C]+mzmWڮ*U3wðdû''{F:BS:ciَBy rBֵ: Ժǫ/~9S_f/T`P96"<VOWgsU/B5"Yg!)dq9>ГLNdϩͭxkmCQu=ϕK1xuŐcTn t̆V}ȸIQDeEN;KTnX JB&Y$)H@> I4o> j=G~UJ Ր%ajrcnCujہ syV XdX2qq bԖ|Elsטm?l!3-)J#_rl:uw#[X@:2%b&Ҷ"8hJf1!d{!,*uUC3Jekl9&#juC8:sLOayվg0[dR$\2fWu rk}[^ d 8fPu[#Lc%m zX3F'?7B}#_3f[BF&DT&%' A4iJަߍ'p_o]/ĬB" !gef-e|X좒ɘ jD'%1TFMnCY?&L`nW-pA*}yKb6*ֈGpHΑJ2VS) c̬CAfKf赉:aʠisc{?"|CLsNTW%!Ǭl*AtrpB/DbGH+''Ƅvq3GyZ.W-Z]NX #&nY6iiO2IyCf< U(`Xخ#pڟ2aCqtñF$\,~yZxսZTqbgHz9NOGVU œooyu%`` ̬L uz,H-)$v6xuERX)g+ ODHRB9N c)0Ζlv CTu-,LF&}=#8Jq@Cҽ'@kХ;Bi@ѢѺҺmZiT٫<\ZMs^x-{n=#Ӿ+"ً(!WeN^W;,}U> 5pf0>5yKvn~yFU鯓wOZjWW.nl?,+q srK`łߣkF'X9BkؙeF_A_ Wo>xbWW rsHMb>ҵG_׏o?z~j<%'hDNFi)5qnAL@ ?}9K 6DШ|Bp`4CЌH^N)M|sO/DeʥH^БHFK,ˤ$V?[Bh/sfPjowEdJgcQ#2^HZ-C&bYh]'D܎3`0&bӿ9VzufJ(vRLヰ+䱗f ?#Lg,Ua,FY,2tl?fs]jF@ݝ摊`6+oT hě᳜5_yRK-D :s~+VZ#D; >󼉘;9E G1qhEsVd^PW^=f0.e6 Xfn^wE\YmDS$ z= sE탁N@av6x|F뾴I<9wPK'o?&v~O[>POvWnވ + )+&iW"6׍LTPVذdb5b9@܁Sܿ ϼRrO'z艘b_ ɷ}S FNqq px !>>CiYDegoG70OT3B.L`2 XP K 쟿gV-XƂǕ֥mɓXKb9K@Bl_zYKP?į:DtG+R.~k_+gFlIDAT^/z6lgR;Byf';ئLlA,.4`R*1Z~v#gC(׷ZP ɓn=J5 nF(&xV壹~e#OѺTP*U uX |26\yKRc1jp%Am7=5LmeOdm̽5BqCgBe L,qUE d]cԴ 0 G))HKu # طkxӾ})T$ۻ?p7ի/Eb8]K"|pp:@lx Y,\Xa9!B1maq+"t]A궤JS,ԝ~$ \!!g10w# Fs?ҩ{ONѺҼ'C7$|Fֽf?O)ᄵ-@՝KRkiT,ХZ) 4Zj*7=D mG _}P\B^xkoFbtq-"#5P@TgvW.KZ:eIA~zJO~x>Q; 㽴'EnСwQDE;J}̶'YˬG)L6 ޚ<)*m=c3DVHJL^7ZՍ PAVzw:1$ww%'dsr۫xiɢ7: !ߩf[ovzW0g1:C36dY柄75t'2}XxO#v#{PTsE8n>Ǩwek 1:=^iۛ%j~PA,G.w0w ү&sdqHHx .MEY$cpeԊ[jEya nn!׶EWшk8ʸb'+]eKT8EIe%7ݍgێNDrӉ +9N>OGodd% S  d~\chBdH {Ȗوp0m:%4̳䑗⭧|/b6_3|E&Yf޹_ٯ?Zhۑ㟝.ߘ_G0kT)X߃XoNES7!佻Π@=ɻg܆#KWݫOMxi_Kq_PݒлKc:<*H~ y=q}8y#-b9OjTi;+wCWu4X1SOwyEy!ʴ >g8q 5Y?s,r^]ȋ^_UԦ ߃-OڽUf %uկ6/YTv4;1[,|=2h,WN2!,f;J8`xrxs3t7x#fbmv۰f@8UO>S%PWLQĪ ʥzL (G05-k+حzqRdܱEƯ+I$$Ukpus=׽AkJ;RzC.,xbx}Q 7m6VYd"c|0 W|(vmO5f/Lۍ0_\]M&f33(}nC[vVz'sqӇ{!Ib $x̵I]I`Q\1j\h6OAn>:=&y1X&LF z&22ł;n-(UJTZ5ZooT(,a25 FY n5.tMv^o<]|{;&Խ'>ֺ~Xxq#wrsE{`68V&DTPӽm:o,?ԵKmʾSGo e2`p,& &U,Ia{JֺI,\T(PLLXskǵt4FNGO[`g@~\=N=SCl#Qr=e@b#Oo﹦Gs9.EɗaV>m_j=9?[9+rưگ`i1ɤ$sa N 9D@#'8NuQ'5)0&ݺ5H8JoɈ†߂ϰ}kq)HgD6$=BSxKI˱|}Q &K~@ܖW1`"} ھoo&S {ox4ZD;Ӈ3p^z`2II+5ύeSQHĔcᘁnn,ID!f)Nb8Aw!d5UÔ'n/^ qn^U 81|ss9'iC^O^5LDMK3QF_:ҵl55Ey{ǕKSDNJb9DPQ*dUSR-Z SUz`9s^]ڀhV"Ifܹt_q kh0Jww$B$%#qE6$n\ 9Őcj fLJk6}HʪY!J8RqC|7yl8`9V:=~n=Nͽy?!p<Ц]ٌcOǑe (E*orJu 8cll< $D2;As[;m!;331"9X`pÑWJ肜ej~٣o*" !@\\BtvR]Aulw7Ѻp`rg%"]兲M^E` #C5l4B}2n\__#W% [BFF xC'W H@R(~hny&e䛠SJZq6p2O1Q(N@*Et: =e@B}gsu4@5ccA"1(Q2Cu'PM$hT[އG*e ))BAiD.MAnv3͙~pF:Yმd 3fL1RH.A.٘1F?m3X6Q&`p ev]\xaqqQR*<%K?hQŒD^`3?,?,?,??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBiological unitHPNG  IHDRc IDATxwxTE?.RwHOHo@:I$H{"RT HQTP.{M1-MyγNs=;wh?dQs??a0+5 _#<݀]XWv_COI랣ڴ 9ʹ ӽV($i|B'$-OYüXʖu} ;Xb:@q\p<)+q󂻹 ›_h<]oqpLl(UJ~,SƨN;5z1ށ|suC/2ɟ 2| @qm; kXwZt7Y~̅LN+=deنC=Ο8 \L@Z&d;e}"hP^޵ށ|sBȵ\OFf?hls?QUSZna.Dl?xֿJvtf>B͕>9pkGZt_C>;j|dKV+ȦB# 'AZVe8+m/gwS M> ?t|@?7pf+Pޠw莃cX$NfH.zFWW oWw/%@-gwSiMŋkXZMsg 18 ;Fzq9U9/6u2/uiGv I%d7dEwGLЕ`T'~|fy?0/&7}h2=|+1 TVP6T!pu[ FP!+3 M'NXF@/x'@A oO3AzIo~>&cߤp]b -@yJU&uD{FaQѨl y xxHbyGl:=ekTd[m\).:‚VkW` \Nk t0s;Wj ~ 2$%K n#IH'K3T?x"HC0Ba(p-7nG"k/8E[t>9oJBWT@B_n?|ƇHӤ8{7z5Vr5O"'vdof9^1 ^ྱu7Mt :_j:^?\8yw  P//ܪ% ';^c 8 ,9WJ`b>}v m[1FeBͫ͗wq`O=^c>(uV{|e7_liѽ[9w+\߱@8P5 ZV7JFegdpm-Vwȵ9stza?q =뿉'-|ǎ6kumx&H;Mzаq+wmLgFy{6G.h ~cFVVN^ eg}[^CD6Ks͛dp# FWQ7X?ܣAWS3Cb_ ^n5g+ _, Vem>fe _VhEFۨ@Pe6};G,GC7e[gmQ/~I]Yh7͟w 268>U {Ɠr`jD lҚ _p;G[|̓;uⁱ9| E!my Z,?^R]2Nߢh2Q9N *Ua [ 5UK7pi23WVw7JOKcfbZTZ2+Sh14TvpjHͺl,,m9̟28|hxO|lZάL_Ů?#PvmŜ۝%32 L?vit,,@%oC_r =Z*l۠2y5fgD6[m'Cf|$t3[ݤu֢T7*adTм yd HS(u@xW BC~yiF>!Me{/g>yiAԋjIdHmz;, -: ~ymm{ or<`|i|m@Fh qB- n`~L;NagOھDu^KҀ ҺHI49J=D;r`ݾQZŪ$y8z m{ >ҩȟ^,x-@Y=FWV]+sQ6 P>AyA&φ7g6%e<qv+RqB|༭@3廎xSxm˯cT^[l]Gl]Ž~#jlAΟF|qt@*״f@ HB:IC/.3HKvh! .Im;WYDe{= O{ܲeK]aOA^~)`rLR?2|u{1Cy AĴͳ-&fӽA慒wnlImM>z)ϟq)p )w \ßTB) fΤ_inu{jxϝH,U["&J7spE-KUXh|(USc;k 0m)ZEJyNCٸj6NDݿ`Ԋ0+vKNҁ׀[7٩1Z XL5W{%UWe@R)[hw< z$'SDqX;XGgcaeIRr> .o6-.>J޽ylU?U?`.>8Nm>э*Uϑd;7ܽyw"%0U1*v}.Z+qQҖugVSW3郵}=vo^heIzjsSzsкHa˦3(?L"PeV&aTkpؖ=VVE}-[<|E=++--ٔaqHb0ykJ6* cҪ.v>8Vjm[]8mT>Ϳ&ЧS$<%UW~! =0Ԓ,4!A2)iXF_0^ 96M1nIV=F7oC=k<-S]q=,-NXm?F+KKҲ\(DaqG<Ϥ>YǁD iqQ"L ͭ{'TJm{WmS m}.}''9jx;J: ̤b>y [WoZn\ByA{8y*6o,Q[UO3 $_3 LZv*^^5/Q\guQFՍTk%~!RAZvQz!o.3*Ӽ}o6-}lc!7Awm;X lA0[C5L/{!ϖWRVLm.1պ ݻ779 QC~Ik=6Ya?Qr[xQ@qYJ΅]r:,U2eː%\"⻰i|ۇSյ6[퇀wJ@S2Ξe6A#]p#Nߗ,s0tR>ksT;iDna!m@5aLu Q9R1I 5S6@1p2yTӍ`!wo;"Eh%(WBIhYϕaޤ%eҫr? E$8E7.ɫ "pl{I~Ԕ甩nO{8N޸Q?*=[LզfG֜8&vx"\1ͼiN}Y0} Odo/v03ٻ.9W`Od&E7RX M3}!~^\Æ*5Pڎ Оm4zԭ:U\tJRLR?>"ef հA58uz7_"WS~ڤi2*:Őxy*rk(AnFTS{1C;I!$: -}NM̙3ui Q& G)[ ,6U:;.Ç+$ 4H/is'($_ #XÚ%I|WqWj1?ϋbFDӻHlr 9$c[W1Q=ݿ#Y\dM`iYgfcl4 &?9uwN`RrbĈ̝;[Wo1/;4hk$'' *[(YO 8D$,]Lc˕I/?#skY_xq&Qv@%̙ΟbKQy_ӰWBo[4~X~%@NgKҾ{F Xz@gnp}u?O|x\Pv+ ϯv⇙/դŊp}ZlIJjhWow~(+3[ӾQ is pg;H>@-#8+ 5-\7c:FJW@ itPݣRx$KgL͒COxC肵7S) g6Ug[ff &=%$"XN7X.8OY2@%Uܽu[֑@7n6t_r\[gfU_D kO%J׳YQ;{JfLpna}`oQέ;hDOkhi'=V,d'ܱ:HғӐ,!L2c~CԶwx|I{Ӡ4^d4N3aS~)T[6RbUjB2BQqY(LhܯPZ.XIʊw?;>\;-\\ͧ;FPxm<ɺOҺ(_³_pɸvl4:UF2+x z,UC0Af;y4|pJVOYYE"Zc7Aǜ4pU%h4;KgpCy|gSKYa㴕hOϋNG[Y>h4Pڎӿ6ȕNpZl 2gou(G@H6-[dRPKE4rW.M =|H9{+k?yߨ_OՈ¡Ûu*/i<&C+R~M0רĶocW5 #Y S\sTXqn(+CJa̢ǐ!<}, 핤k# {XKߴz GnED$u7228m%5:qdV2oWl}$ K;` >W>CW׽Ǹr$g XZYe\p![QP+2%J*@ySKOp|xNyli?Y83ʹT%S AgO.5kJ/tHU>{5F? [ G V5Y_ЂY K* JSC0y(,J*˗3AŴ~z!Gbr.=UN1Jsee.MfF:6XZZQWʩP]}];o"#Y5߲gOQS:?4NstMٺnT빖˦S8ı7?c_*z3L\9`ݫLΫYJKy#=Y5Y.N ęX'RJMBBB6t +3L]{B ͚5;h2ǧ&=M;RZhi}wCʖLqB(G%(\(e%V+0L6Mb^>|ȕCgh=A[qRPCP szoMEȷX~)˂#?ϩ'xrO? " 0a#XK%F~H-GGBPFfEЮt?\>}/o@:vHz& WsWf+HTnЏ0dض9Z[,s{5I$ Wʕx?sen_ǩ[c a6n<ƃ+wU1{O;=oہ\"bRRhm{qI22H}'/]{WKۜ|&sfz/-G >u4V=23{͈ӧrbZz5o4lXWk(LxzPV kсm(\ssړAʭ=3H~Pަ2ɏstwq<36l`Ff*N\-+ 7OVf&o]؉E8++Z/_r2">;=]gw[N]+w*ZO?+Ÿ}EczVvZMϺTuMq7 Ed[t{VnY}&ݻ|T(€q7ׯ?bŊÏG0cP fؿ{©W)\&m4ܻ>'ܼiFZZ ɜl2ƌ1Ƅ~ >c#OgՀ}j\XL…B}^Xtk+wѰM)Ӽ@~RYw,k/pM{º5gC fG4X"Ἶ@ØT~o"x_OH4'Obr3#P5222V~B;'?~S_\*R)}fmz$?{“GF8&Ov!nPnYdfd=22L DL: B8aJޭlۨ |(G YL( "vf п\j-_*US[#ugR3n΅TIIGX?AR<` 0wlw'<Ϯ2_edefF9VܾF"Lf2㻕xp\>!RQύv*3-L8b|ؾ6O&Ӽ>Gщv;L<; YQx]EI ү68({2:d.%YPys~-P;: όt X?ͫܽybHR f#=8QZbhe0,x3?{¡hW]%[Z@дoc7C8σu@>\ݚhza2>!tpKl|=VAC{whO]*ߣm]`\~j^x+Kshxg}=6CHl[";]=6NXZmT׿QD1\˷fþ/%#=|O\;R5 _&ϩ|¯9m[)ZjB2kVK)cObߵqd,S;J|dmz_I f:au :ϹмFkٚsPldE_)nTOP%)4kny`D9:+gћ#X:k OQO_np@"p]Kgbwp7N=ܐ(m]Pzr2sӻJ*LإDOH2jҥu]L{E^2¨|lIH-+ҟs{{;⵩2c&PfSEjyۉg HaޣX9ȈٟJUuݕMm_Kʵn2eH@ftB{%pouu G05". o9sxzzJVķ}w0Be`WrVr EB]5O .%]NǙv򽅅lTɤ^(Tӹ -cY!L69*Ao|C7a-kЁ-6:3P~@}@[Z^\ !tj-. gVxe( ~?}nfYM׷d= J:Դ. 50Du3FDn8 }18×&}Km{c/ekV  3ʫPCjKe2[]cvԨ CD4B =4;syʳӾ=] }O ;X`Hsl;uhao8?txNV{} )g v5cиMZXл*U#$gנ޹|+; tڕdٻA!lHl%8SivfI®\?~>F' i2ѴJҷ\9ΟZ=k*U}u]FutAٮP~9bi(#5qwYvlM&y2 hj8p‚I%Krh Ý>O.d9jXxQKNڽ; %WOFT>_(oaxNPNYXH:RNЕmΝ1 ax45*M{i/hXkI7@Zw&jHeb&!䵊UP\jJu:RݽTΡ5jEy4phG(P_~~zٺu=zT!25|?G at#?N;uj,3xFI5Ym]9w>/QѲ|KQ̯x*jut`O0 pa;4ji ķ^]p!.;MSc5-XOWs%$3:q27_]AT뮴=D:{RT1Bcr,^18&v0v'hwh &j\S8CegmF|4gg-lGm2۾Q66d[+*e֝=qv.n2?~K~s7l멃ڶjKcyʊse0`:8n7OD@|;f U]j{41RܽAgz 1ܸt;7_;F-c])bY9,2omp=8/'w(g]u\{|"y36q_ ?YRݴz)ĝ=Ka 8-}BE6iMrzQ~A ن굹pC-T\h<Ȑ&ZL%=7nq9쐙9[]/VL/VZLpL 9KM/LΌwL y,K΃Dkz҇]J%@9RV,:uҝGFꑾBA<t  &PKЫٱco^l5m{\~?b-#QϾ^6-\O{i,,,:B*LhtiTqj7j V cBFf&+M{AT=K+zJ$C) Y7j.>Hx`,A‡ q U\jI%R-;GM'F-]`6}b.58HX$i'; s"Ta=!aWy IO muz3N e*U-[dsA.>{g!w"u=tw14x&Slw}Wlp2{n iNQA\7U֮+A :%m]dϞ=xvy|/%] /ė|^/K`6% ٫Bb%XIbtfbu4֘n@$*ywu$8DxZ}{x*mڴɵx+:N_O{X4FݹjmF[XȠZYI[s9$75R@^}j;C:L*Um͆*$ٻ[5(c hWM~|e+kJt>f>$- Lju:Tּ}q~a &V\0il) " 3Ʌ 9&|وOHΣK^tߨ  1ڬԏh)mUkOٶr= |bVf2z*y2WA}WuanR88yE =γF-tSҼC6ef&/c̤eޭΟ08gAŪ5qOHl[~7p 9 rbP2q 12n^uؽ;Ο8HpI/~e&}nwWlg_Ϥr=tSQסPgj,B= \"^[t* PdjiW 2~d4F?ȱL}w;EZt"zΰIR^c2䂯+Q]$JD\giIuIFw57Pst'q<y59U'Cs%6g~ĿQ C>R5{U>; @N[$hҟnm}tK∧+|ΚgU6.) Jﯙ_n*zINӐkkvAm|j jTiygPUO6 4qtѳ9yYn,]t0L0~_p6}nu}ʱ"4VS DF I&KkvOj(ɨ}$6i6XA/.%{.%}'/<~a(ՒC9{Gv|0uAP;/oMeJptNL4hYjQ2hQ,//À|?RxiܦG(mC\|JRK$iȇa8߅=PmAK]gOFi]''6LLB^PNeR>A2rr]/ n*Iuk93> d,g}xq#I3F@u ߢ>[A4i4_+<wDJ/(ZT֫'P~Mo4ZXH{dej2=YӶ6c[^#[sxi%rQ@! xgVFEƴ(JwE03ElnwZqJ##9zi?CM?|YL \DM敋&*^#5ڶ7=lUe`GA/9 (=W(aԅڡLIDAT@sƓ4$<c {T:{7k'< @)HVhhe 0m'_7w }(#~: BjJ L˜=,Tg>o*i|0}æ.B9wVK+59v g HQwY*丮dvٍR} rLOQ{\FL<&+ ^*i`AdW`AD9P. P9񬢈PZĨ=VTjLm``9 P)'zIK?QY6LI98~A< jR9GR]͞I0ܹy K+H yYꤸ} ]GH|4įڿ`0'` #mS?#}uqh0X,ظ[߹/`9ҡ>t-%箢D6Į$vӊ/) ,hruf':.}bVP^^}ogG% Iַ`#& 7MS@`^M^PIXzajcNbWZy!h}23gaAR_hr-.ʶ`b@LFĻCgj}l5h^ v=AwW7;Gxޅpk +`nfP-`)w󜚾gFEn6@`5S*!^¤ʷ֫ؿmRqv r.XlvYl4˒F+` `"Ah~pi/|RAzq5tv?a3sQT=s?g MlƳnxCxoBe]3eF⋼2g;$ڕ_ rKnW:.* +K qm|؁߆{;[x]vػU[lN>Bhaj*VHxO,ŌqPi(cs LgPALv+q?bmI2B)z VeSܖlrv!GoN<c?6ZNb|fm߹DΔ&Ϥ u {xԝH2/W*Kl'+kh~UMuБw Pܵ '@ i4=v9įhh@BdWe6Th Xg%X !`| I:o29p$ҹ1c^׹0!'UgXVBg .lltn[mcrϽ]ooW+Hjn͚aw 6fhs})g !n9m1<a5\ラG@'A vs~bI [10|tL,Jgqbxj`7 <ԑw(XFNth@Kb TUa׮em"''zh_6H7` wϱq8ju񳈍dԇxѭ^8 Ir MJݘLX5pB- ]ryZͧ=qJxBȑDUUJ`ȑp:w@PpnUFYYp̝a'N OI%'_ P7е?ܹZ]Yg)i:]X֮]o':@O.7.]`6{4M孷fTV~ND94+|;@e 1=MTUFUxί| t""atatAS@PVx6(f"aav?1 >w-<<4M|%TV±;&A0c6%\TUmjgpݣijƐqq>~'_iwn<U-&X.8e)g7mn8!Px^ht IIg!,znGvRRaҌֿ`;w扌 MP|4(8~nTՃE}&8IMC@Uv4-TUf{J ߬}Ldyz@&]PJŎKMc6v{>II N*\0+JMy֎rڲΤ0qbl>o&-O5).o3;fiON*j&}Wlc fF#UUՋc#een~zD,nG':6$ ^oZљ_%"rLއFTEXir3-Ig]"<Řip<^Q>,a7^bM|xMrԠ[?(nWrdItȂY#₂ˮ7ܖ x0dH6:@=*w-ꝓFXXV >BQ$TmƌW13΄̀JE|/ڻ,AoLZ?zwgfƌ S`xrsZ8$ UZ4@ 4q"joѳ8*Uuc&/'0 h`@BQTT,ZK n+*@\uUo\UMborE#T5ۧA'+4 Yڢ'E lIM} #$?#vn*яQX TՏ A#"PT\[gj۳}zʕWQ2Zy04M#36oGH ASZHRsv:G dzg n\y%%y6++a Y^dߚ< ={#)i12h%116A "LzEnTUAFWs_l'` 0v[20RlTu%%%,&+uF6kدב.~ _.qЗ.k򈉹?`bͳJ Vz zN{U/UT5RS'6FkQ ՎS͇0y{zΦxw^oaͭO;n2'MGdDF#"n/`Y""GQ/yކ!I*7B^s:tgIriSsW׬(;-ƍs9sJ]3A &f0h6;{Y|O&N ?.߿g #e72A׻Fi΍#lݺcg56[4Mb#6a8#Gy89+H棏Aƌd֍|UII; ;>EQU8HR2PYyS}k埛 6M?UPպaag N|;Ǩ HKMjl]y!5>֭k`8)uc$ pR/O=qc'mv4蔠i^IhzuyTUv}f8VXQPg"e0II@so߅\zfd YbSIK=|Oox!v%h*(#Y[@7黵'u|H""zt̲*e>F<GcQF˅-V3gՇ 2pxL5~q[xddᑜ/Aρ*CZñXzoqәh;pUm$[`%,Fiey5c ug\ARU7`+4FZ?#STT7l>&%(6}w; 8۶-I bBnq$w=;xmB.<C$]Hsul={ I/aH~ihBQՖxMUQ'` NBB6JKՐ$7ee\w{!*J:_O#W׹s9?Y&.Άo![e9]xLӂCx^G11>l Ilc6gm-{fQU7Cp$7&cEd%FU#$`\|M^ y9דr{{'[^E z+P|O{*^C:]5ODjvGU}DEY0a)FZh@` N xSUUlK1V\or#. ANRJJ*pMFdd:99+ %omCBgx!_~ٸǥNgoP ХXBi/;)(XDa7deӠÔ߿@kAVt:0"VޣNJne |͍L|=n(!%e*+ن'_wW48~ZhSaaTT][vAy5&STRsF݋ړ+&1)xEi$  IIRR^|i8p≫r݃Ano+Y#dV]cBF?MFFrss9kIwfs&UUQU I#8p+<7s߿[<8hנoy5e,.V tB\KIKȢEZfA0v?8ޡ .eh<ʶ~$%YV(++Jl+T7vF{GVt` "/ 4̀ӹcTrg#Zf[(Zp6\l)- &i Vk&UU7t58)kg"IUnE','3.tFG@\CULC`r#a\m+X N ڴAõ 86p7Jӻk81MOZB-Z|]p\[D6jS;O׮Ȳ†v&LhLָСu?9Ｅ|>TV$&f6$i;{FF'<|j6IGQ&x ڲ[/0mСElw~'sӥǀIhLQ|m@>!NAm:bܸ< Lz߿(]Zz[u[Ӂ@B0z?INҥVg(NTՋI(ƬYomYxP[cĿa0P?Ngnw1^o%99+;t\ fY4:ȰaOiSZu@.QQڕF`3vTVe„4_!?K'(AWa^{ +nzGlȑLV} kU%;;5nY5ӉՄ.]hI#G#&^$&&/hm߾: A(/o8)#cIX86xPC>\}h/0Ee:tcGg@U;gbqRn>joѸEqQ^ރ!Cj%66! Iұx!R]/#--MhL30kۂX?ƽcV^Q?rh@[olOٱ,),ߞ21c^jGMCeepPU@)+>jH0i>lӴa a($y_/n.G7 'ȑ,YAB™3-TU{XZF$ +)< ]fFb 8pXF>#Lɟ$@34h&˗u>nEfɒSn IIZZ_jKh(Ybb!FJKO(W#@ZE /g ~]qF㙸GqqgPZZs/6b$Ɏ89| |*+qȲE8p`5 W\pEԳ{"˗|fذ3II\vBkONNCE, vt M [JxGr X,DDz 1FcF2 N!z=$"vdnN|ػ7sɒLVfMJjw8c j5d̘fMFtL#ꬮldNTTz \EH^u,[x'&&*;ee;((o8Ƀ$}ٍ(J#\OXLE+$&'hiZLZlVj=ڰb9eЧOyy{>|  UU4lx}V\z_5HLiFaaszX 8>*DVxEb ~}W ::M# ֹ?dL"&H~2Ίsk)n.dx׎Ţ'66JII/t:yy Ozt|UXwu$%k kζįX[a>( } nad?QFǛ7ӿ<\O~I*!(gKZb9[axƌV۱طg1' 9QhBP)y=vbcox6[wnF`ﯛpx2Ly#%r 矷д|~y/R\̗m @~4 qb6kRpjPZZeGQ@Enz d}U]8n ~w#˥x<;#~07g6mo.qN~bb2Q?)$&^Ixxv+#2NIIq\Yԋ(-o$y4/cҚL*#<|^92aeZ&eAD1Esij*K/?o~tӵ<䤸G4M@U4Mβ, t?Bde>hב۰wbE2Fq_zXZGp'յkƓ<:Ng`FQ(ȇy>J`ss,zgĈ` r$;PUb"//m2QU`~{jbINT܀QUU;X:ogGPU/gi~_DRZ*  V;|YZ{T'eGAKmy %Ə+@9:Y[4vůi$~X;yyERdKrH||;()y3҆@@L`ʯ).~{=A#aI۔Inׁ,eyy 47oflk<Ș16=,Xxw-IDAThOyE|%%x۪ΈL޶`67MDFK[^^Ȑ!C?t_W˵ 0YY#zs: buhe7kÕ$Hf֭,9> >WXrr6 Chwuqs##ۼ/c7dԨziTrZm > Mىdz^Yn{C>'Ndى$~/O8Fc8Xr]kKJi]8'| ;]]piIM$e,.BV=j,K<.W.\E||*˗_ETT*>_E=mۖs% OU楬[.W9w7\)xDU9 Aغ5c[UPc+t:nȲ9s…'): 8/݌F7y+0y0*k׋lƍss]=6}l$ʐ%w`V@DEJKs%8!IvTՁTl:4 [0`&S$hhk|/,[R'vkqSVzߥXn?㬳^AQdgƍ`x1".\ĸq +p'aسg<߿B 'eV}4~W{'W  z E6m_ Ӧ-k*+KXn>m٩{0?1^ҁU!׊[O!I-󛛻G爈HJdeϩ}-W^rP~W *UnȐW냵Iu:/:OIf'SU, pjXMF\}c}uxޓ;u)45ǬoL<_׊0-@rEaC~嶋4G}_UVa4ZE=: Q,io<]U7Vg(;1焊 k9rj&v~LSTpP<[.aϘ5'rϹ],&<x(9r~ |F^\6/7օB߾t2tJJ  t<YQFd۶\wݫr}_m~bѼ#r~ =z BTVR%1廇fAlnڈ|FO?mpK[C< t<Х CXsUyf3 zrOm :t:YՄyLjrs.dgÚ5rsuJi*!66Nqyc$ee?~4rj{,Cշ xfc0.g\\? [w7/̉ζ.g^q1/tA@Wqky<|BxwXnqjLz=fsl޽S)/j~}A@`ΜwXhamw O3iҘڄPJRXd0(i6+:=C['N@þ}˸'ٱ#tFD>u7U?4\B0``Mt4c2of??:l''g;ѣ1t CQi*O~8|8Ç0.=F2x;HIId/),\!:̚d䬥g!+Ot/ r߸}jV{t2>̟v>3 ƄQowڭUE4ܲ]p2.Yƭ(T2U5aѠ Lz7uKL C 3f=\Ԫb h: X`&^-z gѬYs4ow|^V5k/߆d B`$͒?.$7$I q2B؂f?뢢l**ٱnޑ#8A`kMxi6vW_#|uMG>4 /Z EaNG?tr o`D"!:DQkW<ť-~xR 4|xDu80XpMTvXϚhSU<&N݋%??t֖"3$I fG;B+uqYס26$݅.]K=xYצ Dx~,F# 1!NGg8p4;w) >ya*5B4}ݼlRSGrÕpWlذY<С$uIҡ9kpS@iim uCl,GDpN4<*1]CԩY,XF>LHk"lg~DEűmѩ*-mBmUOdH4"Ep֭), ڛM+5\ܹqMW췹̼6]aa(x|$+RGmXVi|9 ҅t!%P,~)K.N=[7Ծ}طo_5bc?GFRP/~)SnU\|hʑ#(.{lTVVv:AK>}~fgeiW_}y5ȑhND;f-+khQQtmʔjij7ϟ}LGiѻ7[0`6bZnCB<֭hpE`:Pw+*5RR87kZ[׋i{4b7"̙$z I6ٟ~y~3}KcH!!!4 y."p ~v ]?{#\eae%"O&0zq%/ P3s6_J5Զ<}\]YQ3׏ 81tt:N'f̘,IHk$?I (rmKJT+ƍ vj"*Ν汙]i(O802vz/N;0Jo*+Y؀U3Sex{wz"3=1^/_WV֣8`W\}5& !"A~~>ϧ^Ap$!2I4@ {70x0q[hX[7܀bPrQrvbb!U3g'yy9l(zΞ=`Jmë(QkzgD<5n=kW!gָihZ0X N1 :VGsMu#.'O>~ʋuWmƍSb6ub..G⨪b<&*+/;"=j{0"l †)'5-TOLd!+1c~eel)8[oi0m~ݤƍBgu`l :{~`pElr9TRbԸ4kj<󯄅ZM$'$\? E ($UrMS Klp#y챶ө4U"II؀fW(|˷ނj1g4(<Vkp܀s:B)uk^?,df$L ZAnƌyPYzܸ`x j'd ^,x_N;mf3н{/{ďT:sN Y66QcO6jweںGv'hd4b00"V۾{̸3^M!;{WSͯ rq}:mٌ{] n~ Uh0_1/dȵ)|;N[R[HUv;KIah{p8X[Q-+|q<$YFg2!q6駭`Οyb&^۵V+61()*Mv~zhpAoBjߟcbx䇆d7re| gO]o3Ғ6no7Db7YM 9ͳ$;IUy||~?x{.^ODx8wf]CZK].bxժe|?k=~;G}fʔq8i'| 􌈠ot4a *R׮%ث IQ0 [ov:$=%=?vRBxF" 1<-館>}ې͆l>lbQ[) c[iԴu oHx Ss )9VB;K-IENDB`move=1000;blend=1000;3DR3   QUOjG֢@ZցkTQ֪ZjGZHBHBOh  &!/3`ŵH:fLqfH VĤ,VN"-\3F'Jl)H( ˋHX b}3EGGF  ΊJifd@`8B0bR@x|p"v) dᡀP'\}X`5TX6m^yej0'Thɫ) $˕fq36/TS'yKZ>*(Z}Z1bN9iK@/l%Ċq }c_ub 4A'_p CD,Xm3<\Lx"ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 13DR3B1\\ UOjG֢@ZցkTQ֪ZjGZHBHBOR?j#ZUOGTkR?BBUSZP֩ZG֪?jZ֫ $$jԏEGZHj֨?USQUԏ_!$!$UT֤j*?GhVEjZ֤! $$! $Z#QQ֠?R?@Z(UTTF#WAI$!$!I'U?ZjZխQDZj֪5jBI! !BI?֪HTT?֭j#U?UQHUBIIBI@[ fQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JpDubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac110ubinding site for residue na a 336ac2  10~binding site for residue mlt a 337ac3 4 10ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11H ubinding site for residue na a 336ac2  1H ~binding site for residue mlt a 337ac3 4 1H ubinding site for residue na a 335ac11 ubinding site for residue na a 336ac2  1 ~binding site for residue mlt a 337ac3 4 1 ?333333?333333?333333???????@??? $=?@xYAB@?@H?@H?@H??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surfacerPNG  IHDRc IDATxi-u]sՙﾡs)8KMr40J"%6|I 8@@q $ p!ðŊ"!XhYIDu~^LujܵkW>Ti6'u?Ywq_:WP.֣]@~/=yQx X4=F!/=[z"gkCuRQTG}k[o[.`8΂)ŷ#7^Ŝ$٧( Q޻xdֹs?ͳ loq*g6{__/n[y Zu&mw}cwuK?/e)?|]#<;;?AlSU9J-98EG5⸇m~ǩ<Ѻ`}ݦkox~H9ŶnsxR&y3w|=)%ل 5U޾/.>|?۽ )ZW8! â(H>7oJ,!LB}k(JAvuo?x:Bð*!,  RS)e׮u_k,,!I>Z ÷뽋o1ʱ,b nǥK}^z) Q*,ga ݚ$ %J)9 [[{t m2(CV傺.ZTry@Qh]Q%ax\uv[~NR5]wLk ~?v|?xh @ K lۣ5e9'8`Y]&TFY()v)f~^1Mlm]Ʋ.r*#: c!$I)Eqa䐳}tNt0MpLZc?1ZKbɍ/#0@l8ΐgp7ogt:OԼ5xy# C`pmL4>ҥe1OJYvDz֨F(Upv&噽ߵ|3#|NgQ EW.%`o4q#f8f|0| $MkkR.9d0¶=*0lRsL4?_ LӦ|z :5|eyQ*G!Ruo?ٟELb2~{tvYYYC;wrr2,} C8cP*_tcz.Hsl 3q||_PE/e Lmpnw)SxBQh}-0$WߦGQW}4¶%Y64/1>EUvf{LҴ$6p5ro[[cE,=~Nq| vwe<QdB|sBxjJ{{$u 67#ll\c6s&Lӣ߇41ջd0qԵ`pW "MvGq.Bؤgg_#0MjbKbFY.0#Z>RuL88x*B%34oж[l{ `6u-y'o.²Y[qvQ_wEph3t5q5%''S:>ijcYCgϲ#Q#>aa2fuwsFWBDQܽk*Mxy*HlBU0 !k$m13aﯡu7ZoBTUN^(U7fuu?N E)ye dlvluFAYL9;),c4GHCp(˘AUͰ1rr"7,XY4< 8gghw|ԵJ,k@a}ZP1MY, /8C,.Gx&=IJB*4om Py_2VSUJH`4:q&t[a Xq"-}NB,)IAPU)I2#R1 2>EfoP0ڢ mp] 4#llL)S9;;_gO9>>AD 2& 1ku$tFj8ΤݒB<"U呦7mbJYd4i O Y(0M-n%Q 3d}F )ˊ+r<_'L/a)i:k9[[#"^'瀚 7cy^S YŲF"Ir hΒ5ph#p zhP#jNOөփJrNNU=.÷\] ,O ['8,Sma.bYBd@MU5ԿRr^Y[X$Ϗ 9LJ@)AvRϿ ammᡢ,!mC "(%I2W~.uKUϴIۘ ll\ $OHNN"jIy[-m Ðuð/e$MO=y{(u)|17o;ߴ.F4" JMqky3꺠#gmк,#vOkI;{0ip4ZCsmL2l8._SUtIU$IiVhmCU^zI*2jx0á.5E8΀}2a)Wq|$SZk)P*uzZc},khR3ݻZo)ɨk\x7޸CY '&Mc!eO:=u7(aPOɲgrVWm\wDψ$QSQteyBץuEuEQ,v^xaid0~P۷%gt:/O>iŹs+ܹ6 кN1 CpiDI0vJȲ83X u-1_css7@9UR RNۅ:Em HӗaڅpRjUjPYL#ULS`Y BX)9w|.ɲLww~gc0ax\b=ӁhDð#NȲeT uw0͚$ŕ+?N$(CQ,ggZ7`gܻ;T l1M Q&U5S v;zGTUJQ'֭!l.:oviQh]RU3 װ0 <lBQWZuw[[#DiEy~u=,j?d|S=צkXV0U;GUhD)G=xk<,y4Eʛ>e$1P3%$IDϹuPa`&J@F't֑k9QtmlĹs+iݸm Ay~LkFQq LC쳬1a^.y#\wYYg4Z'M 4;x.ෝ4;Hymogg6Aʽ{_beojZ+Y6<CayòvmvvΑ I(˘o{FxE!:8%&WŶ4)euJ7B|+!0 9ZAj=f3j+,kleyR2lm'7]i¥ xK㺻llD"$*.E, D (Pc C] i%J5IQBlSU].]|~fhIJ~[Ak{U5TU>eYRhmS9O])KNC+f3ZQoߤ%L'WE&Yv-h<0Bxt)KN,& OU޽jV,b6K[ߒ88<c=i;Fl|r8cOnrE\'nd=dkqJe{ % &Ztic#s:$I]ŒgNg̓O7F]+l%q6tQT2Xd{R׽>aۣyL(˜m6SxmW|yLQL&wBvMa}.''\&HqpUXVBB#TB]TUixE?x$9c8PUKa.OJO贬`"fÙuG}4(d>/&˾geeAx+maoI]7?>Qʤ,k|& W v(>Wm45 °)HyE10W_}p.A`ۂ"*}b4Z~`0}auu+\2zFP>ѡ4"1=q19YtRbѐq^hSJFIk0n`0"IQ(&4]\N2!\"#b&?;{/F8wz͛_0bjeaY#$,._~{8lA0 +{<^[=AE1E`>owGTUzƫuf! BxIy\6Z@ b0!Rzᵼٲ0)Rma9I#1Wg8@~Ya }aԸB)uӴ)%RF>`Y]lcehe:=j|²4i6(#NNnEǔ&uy&GG_0Mae | IDAT Rayvw)ߜ8B5GdY&u]P9IrVquX.(.g`d2AyA5} p]Yx izzM:nc9 M Qɲa#|ϓe5a;zP2R\Gĭ0lk:,l)Mfiro:뚦( lllJ.s'lWh,oPe+C`ðX]=mZG?z [A+ς<#IL"y _]ZePjNs]Ugee&M! ]nz:q6 1f[4 R,K@DZ1ͧF篿cVT= 7q!U%t$4ݠ9եRg引r㬒Muyr=h)gaTUEQQhAG6B(NNԐnwXXeCO{+*xJ!q)ʗOn"\Ro;`2x #Iӊ& o0 d24 @ BHi\FYbu;;!MAѶ):4ӌ'Mpu]#eDY&, 4|8GèȲֽ7iAib۽̉m㨖ү{iY.˜E]+"OMT뒽Cvv X_79>.k?󘲌bFUI)J-]a8ܠ,M꺦ӹ 4MG),;B0MъLΑ p"R `&=NN l; Indy$KXV3VqU@0<ޒaN#| Th]Q9Ri< tSh1U齶`ԲTm]la}gǹMK.Y,N9h>Is74JҴeUm\V$wv/燄a8ΘNr04໘I$Ȳd]iz$y0VdRUut.C4Ĵ75=o"#s jL}`6[RH](um73x&Cd%Rfdْ8>BL';G-ὗ!Ll; \(˄$Ks0…1u9<\P(TEԬHΐO|, hNg `.BX ~>۶/] &)&z;7 m/\߳ k]c|ߡ=si*|)^o(JvmyAYNIf`9cGP0BE3NN mSbZ6;A)kl@5Np{ m/]/18mFHYeCxIqzj\2_ Wpg-1Zk.qn; F"_~$mۛN}f²?|WP Yv:]z-pp8;(8;^l#3bA2qzL4]$3ZNjV(?g8j$mgg/1_LLӠOH}|86N!ib-⨽_0,||a~*ܹ>W 8:I=W - )˺OQjF]iTU d+egt1ͦk3'TUN:.kkl;$:dnm28rn(4$EQP )gg9:pM| 2c"JEt:O`AayrPLxݦ6Ih8qc]4"x(NNn$bضfa)y^usjƼ4 Ũ-Cp6' 88G,&AM]k:˥a@G4g sٶ8N8[oF?~fd4ڤJ2# <H$3^5ˆ+)YvXa8| mwhjD簬-uJ[Z=C )8ΐ deQ]v)t+@;BAsnSp,qA0$: nbKTJ)ˤ0MX4sQ hN(A9y~J7&i1~8qdOtXK+$IR~ ڂ眪Jm~ISɍ,rIM%,ˢ*L"~xhy͛u0j @7bQ*#lo,x_b4D6OE.gŖhR뚺X]]? J|8N`:M(˒6)9!4]{PLt>i o^(VS|at0M3"e9$ǬV?UV\h6ר X 蔲ïv m,#>'DA ]%1}nປANeQ) e i.u ׻`p/~:ƌJ؉ξIhVc d\[fs.RUSvw@r+t}I.1 ;kFS\\Msv{fI(yuwK?>? IFF$b@UE󠍮ǔeFE ]m%Yv4+2}|ZE,SJl"I$%?&MWlmݓW=vw'W_ +G_%OU ɉi6u(]aY}°֖%N"xE?a`8K_rEy]T0<~?A-I[5g/a]Y5E(čN7R ~px@e BJw.Ѽ%mZ~0b,+g>dr$7.U Vk]vwojq3uxZZݦf8em Iu]3C@5$"RsT$Ib'Nh4P-n߾IY,$ Y.Lv*aL`sqlHҴ /u?bїSmʝ1URUPU4t:Bۿ@,q2x@m!eje`c ,.8"x8%I&hHQk18-J\EH-q͋l8mnZ(xkpvI]ӌ4 ^Ggd]wSJiSgKUf-r~4- *ER:y^P5j\1ڈȩ#"WUUB-GXqN,L3&MmZJeX@_JX:~iB.2,D[%%IƔe"Yi5fPդAU h%7aa%eY?yw;,'( 躀f•hYC:1TAOqxXP5&t"Ifln8sSt]u9=Z=²ı7=Lӥ(!:UI5z(c$IȲ'O#x$ɥ4U2-(IIc꺠jcm6 ˌ[X< 꺤q//x^GD E Ёtd$乏Sږn6/qiVDт,A0e8%1kf҈RKһe {(ZJaN!R:D).㬡(/9e> )EEIyenA2yEDU S$v\6jܾ" 4g6[i6U`&MU|Y](eS,kёuIPUM LR)O~ *^50ڄ{}fsSι㏚(ː8>Gd~9we6Kh6 #a>)өedǶ&Ѥ, Pu1D(#2"%{~]рmfer5\QU,Bݯ8 kMQծT% ޠH Q4[s. ÓzMPzUlc4׮QUnonoynhczJUdMȔ u]IQ! '&M<}5LKwFc -g>q]A \\ryA _;XVèim, J#4|l6a$Q46XVfӢ,3t}N稪zD`<YD$^ȟE f?Nߥth(J`RmS5f_ehλaqq!h],e2YPNWRёXqT(i6\yQ=Dx=sdMscssV+VykHøAaR)CT$M'V2NPUE.!jIR.5G4iZj\\|DNOgE _٢۽qu/si6Ng]`ێޤXX(><|U@@hsy,/bm,Ƞ0;O 1y]6_+lmh4ذ~Sq,S8vr899n"Wm4PUNGh?EUr6{(fVkWT!ؘQQUa8GGPWH;[V+dxRN肺V$IMl`y)WM 4e:ɲ u]bY],Rax*l;ri+%NyG}bAHvX k R*Ԭ Rf7޸ɻg 6, _r~~c5~ZR7yLu%90^c,˥]l{E)UU3(`>![Xr^ ]ccz]5VEmtPU E\ 0(۞3> MgryrG<]c{)׮oݻTUļ+MV98ϗY[{ `Iw) PՊm@M&s"d2y8+]w $Ŋ<_cF'|W >:lC,"/x\k6Y@KK=?DUS<"]`Mgf,Mq{w$a+a0&tE"N5(Jʢ۽sx3ĊD0bCjhwvQhixL߹A?nw0 (LBD{^[Oγg7A0uNGrol6p] 3ϣG;ݤJZF=\wHml^u{ܹ4Fuzm]1ANSnw]V+k졪&q\K\a8c4fUWIޖb-Z/ ۶=&2޽>YFUf0!KX0I*pmP1GGTG1O~o|㡼nGl10QUh8$Ihthqx4㈏?$iZQ>|Kj/]Cj8^`n5M\pR40)4P\-vi60 (I ²Ĵ;I朝9>ucmrYrggIrYe-0EK)SE04s/%Y%ͯeyqkܼh$I珙u9quTI GO8<,0M,%gm^b ~ rzڢ,\nr=xޒ8hl\q"B0 MIXc2c_ܸw8;=`*QUBK/ EYu,"]g ֈ)XN <'U8t0M$ND~o!b( Lsp"*A0-w(PI1,SE޽7aIZEpxnw8}DHaxkB} 7*^;S2&Mu^{CZ-8,3BQJ> NqiMY&,ȲV#:{;T("N4i6;o0Zpt5#2XECltQU5s:FֱmUAFUet/w 3:ө| f=+\w@ܺ5;w"+5S:qDdruOQI2qZ|3Vd*hbv{l+=i:a>?$4h4!ID&$Ɋ88t4ivlU,%f23l.K4%izy/(#djE,QZEtY_1wXN ~D$%|Rv0&u]Egt"4[b=|ERa0AQ@U+4=66y:*i56GG4@IΝc<>q|ǣ(J''STLӖspjDъg<{ߣ׻CǤ(jrt$Nj -Ē3&I!UUoZVf:y)''#p8$%I(S`0x:Ap)f[km%/MdE,RF9I2ÿ*vQKhtu*K*V>Pk[S9Qtmx, NR%şҊ' 2 ÕiM:}Y|xeˈs o$3՘ϟl+{)զ:qne U5i[<}:# 2!t&eAUe| HA]wp8X[Z5<y{xmEĘdْnAnJd*EcuҥlU\D|X,\\<0⣏z/#q\ak놜Vy6Nu_c*AsxGTbs&3L#C4MGuNOCH?#tJ!64 c Lk ؂8RY\>a<>k'/%U$>)!5K% 1],AUܿ?(eq>tsòzÈɲ%*"m{eu4(ȝa4]JGx5<%"/VtcDW/oL_Zz}<9Ϟ۠J^$96Njooߨ ,Ip,6>%3op\\EeRRS\3S D3B}2DNm 9TܥoNψB]פ"b2pzzsi [pOip-)׍( FûQ5xޖxyޥG\ Ir }~ӫ*9qex,˘,uV)4}ʲр_M) -&xuLD4@q\:aX1M8[z 8r4Y->ׯq|K+>}f|1Hʓuv6e>IӂSV%X6ߟ|+t:(LTU]>f u uE UJbL}v:iyWA 2ģ,sp,'9CRrEQhLY鰮;(N{nw^GQT{K.FV P0 n$+>b0xQ]'/uO>eU`QU$WR<9FE) ˲.ݿXLxHPUE%qs|2:Qd4+)UUs}57H =o[2p,|6>;;wI\xANI|EPgDY.3?h߬(bFޖWmA0+7i ,I[qrreQU6{wt:Y;lm\\"ې?R:B\Vp1.q|jB!I2'{}I5(K!+( MXCE3]P%"&ֆa떴-7I`Hq*d*mlOrD+DRNBOx"k˧L'M/Ȳ$Y`Y,hıS&0Wmeiȉ ]z7M^ye(J+`oUg6h~ѣ'Dzx,=KB,$ME_%ch4n&p=G!I 3'4lntjyb.!Wh5!Ffd4ZQU  Y Cq󪪂C`XIi^ J}dtI2rϊoKt]rՌ(DxȲxA\H>t:7qMlCjbjs획OY]joh ƒ4|gg(2VsDVՈ̮tiTssdX!e;Z7#Dŋ3'VV9MdY@aTz8+Dzz n9I!mGjFM ,޽5~wk50y{,JRU闹Lv ^ݿIi6Ŝ,Spݮ\U :.hڂ,yR]ohZ ])xjKcMUTUryhߧu(ɻx+?9iih6 gʯsЧa<,Q?bƴZޠ_qNÇb9ѣV%iɡ X5 o6gg  4DUWЩ*.DZ44B~( U VCtnAh^qTTeu/~ϷXm;㏏9<o 1)Ii M459>sF? ,LΘ_E2(Ϣޤ$B ㏿JUell0W>y^:i%u]?×$VM.o~~m|:'-rY TU:\9Vh1>N:UUJ`%'É,.#l54M_2ܖ+Ns\ג({vW|< sOPA`1?%I1.3 BP;Eı)x^AXe TUt:}-AZ-HS_q, xNUW4]\>V߆t:h:J,⾛mLzr>Slai>m8,/s CK~|.|?%MlL8DD:U4MRߐ4eO+t:* aW^o@wh4`6;3:;#cb4:,+f㐦)eY2WJØbL,}:|H4]^'3}LSD$LjhZ]w^ 8}ʲi=E=lFޠ0<S&r]Pө GQUۿBL&ߐh ðFOQnEc,BQTi jE=ONЙyo[_( &1NݻP1}$G^lrnc锲,IVzrP0?U4ApJ^UdYeTq8ELLeE)011SQUY#BkdhMsCϞ} PU9^ͭ[ﾛnER: q#R&@lla_PfT zbjJN:{C9ӗޑ^P>>0|M$tV+qw) Ð,̉"YV8N~PU(*LuS"ힲZz*bcޗ\Jc7JfbkMxlPu0,8= 4LS*e)MPyS pjuH/*Y&".ADGt:>??ht֎7BCOIDATDb9hjy|3E4=KݻY[{EAUլs~ iiV](JjHwJGoXG6E)dۜy>&V'e{VGx l']Yd,K<_ʝژNml{WvwoEiq)A0 nI1[?|nw] ,VKe)jIY&ܸEg=tt]$I\,ī*bStdk:(9IR:M,ZC)1qiYeIR"8 2:Ք0B%uQtxteNc>?I168: 1˲YV08NrEn rk0ǩDV\R"OXX[W61nQ>()^Q\,H@4*E$ Ɛ^-}LS!gWUU PCvvl|$MC{﫤iÇ]D 567D_B४UTQ('8MԵEq\$Jt0 ɲ0ےH^P " fVKv%It:4MZh:-Vklg BHcrD:3u `:$Ɍ4]JNL4'@p 5Ls (4eSDZCP͂pqё)3x#Qx0CEecc`0`0J|IXFnji*gg"Ե 4M84 d21ipR7}kAY :q\>JW)y.0,a> ;;3ߣyE F8A-x<ۮh!"0}>MUE=M$qyBW.Ex-<$G9@uVK?h^,v.8;;BtNO0҆4 0 s(iⲇ$o I,(VZv+A(&gg/x㍛2n޼E0 jt@o{Gyߜgvg޵cbpR$h -@HUP/{߻wR%TʩRDc'>dOޝn/w -_ZʚgyAJcRC:Lvb&G躉R1EXdiB\pep, ,Nwv{aĴw(,W^Ydk˧o$m]DdO$Me0lIL(Iũ Ji$W"7n| phV,AVU~nnsAKKdn){=" ,ff[o]E^4mffT튤z@:_}_$U_nj #TU7vz_oJލߓ YP.J^?oƑ<_Eq,aV@l"L3"2.aloesE ,bBX%Mf"4Se UiBrݖ;BʜeqvsHӬbE9aVQE )tn*L`p<1W_32]0 r?^?O$dp"b˟L ˲4NE.S4MDzT I&~پ"TdKT8sgTX+m?bS *S¶˒'ԣT:MP#Mu`%ՠb$}IiUqh-."CK,9k3?ۈD0Cb3lnVkǩO4OS.㭷~w88R ^̅ uv0M[.x(F }$I1>g^|!YuZ!!A03@1&O?%Rx5 )9 D,!Tyсph\`v1<8 4/v{ryjQF3ŸǙZ]]]>dnJ ,+ܽ+ yvGLp%>yQNtQL&۠PL ]TDP,XZpp}ANI'M,IBߦP^_"χ -VW  G,,or>';mO Gxx㷌F#> aF .Ir]@Q499KZFӊ$u){@$рB-Q#99tGUNȗ˧w};Ddzzts{?ʵ{Ǫx^̜bc&;E$e4 2k=~U4Y֡wU|ɥKR/EqGX[eG]0Jh(8naY6qea,-嬭}mcYe4M8'I@+s1t=88+x?UElmE,aoosΘ "L/3n l{Bu~ٳ~HMI(qӑJ"V;KE-sx+rn`B>E]ji|s> Grsxߐ$SIJ°I#χ88#]2e"]4[o&=9F"oa~-",Ul{U.`RZ(& t:ܺ^ïñ<+b8}t"nP0lJ.4q! ;i?mVU[޿8'NYSTDI&Ə]֥KEIKOJ};|_M>[u5Lz v T*'qAvbsx+ض+G߿ǵkZ^ AS/an۞ap]?>ݏcQ</0m0mQc&' >7o~Y\|g)kի"o 8:  p% q16\.*kߩh&GA]B}DNM3]tr.zٟcY.)T>מt`;,y8sfEAYXVAdRujr_$.ؙ3+ʚ<K~zEMhIENDB`move=1000;blend=1000;3DR3   $* $I$I*Q    I%U0t1x.ţ0HҔ)IJ)J׵#F#B1"JvL'0pL(Wfff+rvy;e;O2woY{NsF`4 B]#8j8. `]΄QD, XBt ^#KJL)d):.UQHzd 4"BbbCG (yBE B8 \ 0pq"N,Xb =3L$a.@9˺4eIҔ)JJiѥyT}€XZ F4b]EYEbYe]v,]s QMI*ՙ`*= *T 4pƉ.D *Xĉ,d,LQQS *aUTI&&VQURc:s1i!Fs9ЃK״aEtAfֵ2dQ1QÌ,XHh&=4HBYy-',2UucH 'l|zwww]۾h( @B@&wr ffd/<ڣY̽w7+mFw77+QEֽVRTe)ډVܕoھ7֨Ń̝kZ^,E}kW*T*"QQ}wkyFyy'{}rw{N֝:_eHƑ F eW]ecEI$kZVj(5%Tct#,jf#F+B4q9HҔZ68R,$ᡡᡡh  &!/3`ŵH:fLqfH VĤ,VN"-\3F'Jl)H( ˋHX b}3EGGF  ΊJifd@`8B0bR@x|p"v) dᡀP'\}X`5TX6m^yej0'Thɫ) $˕fq36/TS'yKZ>*(Z}Z1bN9iK@/l%Ċq }c_ub 4A'_p CD,Xm3<\Lx"ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 13DR3B1\\ UOjG֢@ZցkTQ֪ZjGZHBHBOR?j#ZUOGTkR?BBUSZP֩ZG֪?jZ֫ $$jԏEGZHj֨?USQUԏ_!$!$UT֤j*?GhVEjZ֤! $$! $Z#QQ֠?R?@Z(UTTF#WAI$!$!I'U?ZjZխQDZj֪5jBI! !BI?֪HTT?֭j#U?UQHUBIIBI@[ fQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JpDubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac110ubinding site for residue na a 336ac2  10~binding site for residue mlt a 337ac3 4 10ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11H ubinding site for residue na a 336ac2  1H ~binding site for residue mlt a 337ac3 4 1H ubinding site for residue na a 335ac11 ubinding site for residue na a 336ac2  1 ~binding site for residue mlt a 337ac3 4 1 ?333333?333333?333333???????@???'$=?@xYAB@?@H?@H?@H??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xConsurf PNG  IHDRc IDATxyd]ykċ="#r\*W$kdm141 z>v4 ˁ1n<`ȶlbd%j2rόjeٴK='N޻~+j?_Oԯ0<<8Ƿx5|Zm\.OX7~O#}/ȳM$I9BBE!?sx\i[߇i.c:\,u4p]j?䙞~+Vi.ض~x\%o?^VAQT7Ѵ"|$9rs~;xc O}M\5ˣIxq3ޯ_w;UZ<8Qčo“o!SU0ڂ-u aq]/v1>޻f( 7ٿh@qyzU_+2ھOIM'uޖoFae_M#Ͻ~hZA06RA'ރjwPnBU5Ȧhn;o;wv9')X)yoR뾇'Mn(ZH$CeE"͛o' *Q,bm|>+cOOy6 N:MN}rhuXAI0ijEdY4m4&gll .T{qC 8qz!"qvߌ}o ,ϛB3p nKX:("y,%L< J<vr9غĩSkml12QvV*x|M7<˿ER%Iq6J'?,ttP2X( ?cTL%ts{; !d9qeQj@@ғ'ɩ*IcZl>?'?Mp%}ͭra ^*!S=Z1EX,;v5Ȳ(rص]T;n /i%44D>Õe>3y>KHRA$,6Nl2DEMu\Uq,l#y Õr'~fFI$DQD>/3j-Rbxx;2K8N4͘IɲbJqH~OP9<8Eq䡇y4q!!##%[-_ "\caisy.r98,ssZ ďا^@?z,ϿЇ^.ŶME'^d||'a 1jRdȾ};'+_ŶudY4 ؞GGeZ q8y[gY.j #g Ô$ q'>ފt](\ܹr˻A01!p:*i}w YF''unM.#2|B cY&I"R1YVt=4=3t}慯>P(X_Y!MSFnE4~oh4E IBL#0::.ƶQ55<ҥ~4aQ>#W!վwߖϧ>'YTe{p]z} x;~1<bhEqDDtˀ@$Iݷ&YI,J.^ C,ۦi:.Mb;8wB24&&N=i4tŮf;"O.gtgbYDQp]NgyEQll'$i.# G(J$C]_! \$/"ajMaeǻ8{ωmqÐvMAӈǞXVNtpuVVz qK|[`Ll2*G>  00p\6IpJĝw Gw ud٧PȐeQďo6#򘦁]7y䑧KVv)Q*#I\<r=*w%ވ<1Zm0 HӘ 0 u \i/FF`levcvn_dzVdY@ח pشi+Ƚv?ghh bxt[9p> :{nk_{juӼw2`"2>e˓ af=x,_cOkkiQ*nJ.sU뿐$.=ADcVVѴ1Q4ȑ{jj$Y^^Eʐv[w c(Jry(*u۹{Tr“q[,$Blr'O~lo;ÇtPU xH5eiXʫ9sZm|,h4A,LLXdM: 33{Xv]tۦk\Z]ضޟBD bYaeYH ۶}bFc"1?2|I($ lI$߳"^A95gy ,υ _gfF cq8ccQZ qҫjX6DQa˖.-DQ2;8]$I&BjI*y&07wQ,y:S$SerrRiJDդб2JeM5kNܲZ$1k/++[^KH:۷& I946Y\|8ah yJժ6~8$8qeuU#!oqjjt-@{K$]3vHS8I*=ELSy|,eEcg+ cG)obg$Avm?@|^cbb$Iqgq^ql+00\2nVW'I<$`t$EFFt:Rبm3cc=;yÊљ{?@Ujc Mr inl\eueqN~ryMk`TF(P" 'OAsaw4 aY6b!kll"B"8C_8')\ѣOQoe+ejiۘqBPP(A \.enn繸H4|I,m^xU~7*ӔJChZY.""AQ4,4q%;д!,/WunyxevQQ^hˍ7bh]D_DUfgu .O?1@I9if%EU{5dE'2V=Ak R(=:;#9,ѸD'AE61Y+ Qߒ<{06T\g>IbY eߦVƒ}׶EDTpuh6#ΜyfZLSGdYH"i CضM\&"!#{|M+{ssmZ$I/&[ȲBڗ"xȲב@ 8 $`x4 Ciַ`6QiCm{Eiqto0m LiCTcerZ"SOEQ3y'T7(18Vq.}ncǎfZz%׵<]_bl,-$)ٳ_AK8)G(Y_Je;}ccoAU6fve~`v_EӚL|k=oםoi T )XVHƤii^bxx7'4{c,+0::ʊA@OW& DZΞߊ$>]9e s$eV }.0VH' A"IBm(i6s~5, c 7s\wݻyxbxfv,K 94CӪd>F;qURmb``;@E|?…/TBHdYBj8s&w;W;mUi6oZO>?89|_a$I4-گ=KYYq )u$mݬ>-iޟeb^<1o%OG?V󞝼m|Q%t4m+(*iF?-uY]K\Mu7M@,hLQ(T8Mx0KB茏ۧ&&X'B$SʳW:B BD"+q 1iK8p>׾={S*58O`KV!:b릦xi(}t*^]Ut:-6m !4H14TDzz71= ;c|~+ 8iD%A`n@Q}IL;L?o6ס9a,&A` yI~:yx-73]1mr0USgbc`۶9~"ѧ58{x(E5^}k\(}w> /<ȁb|w35<&~[# 밺z:`{Vw05u##2;XcZ(R|qz ֡*udRY#T5G>'%*cdYDiwHzjuӼطWLp=ѶhZ Qi4j{ xNy"O(=qqKx?w⎝$3%.]:, `G<ee 79IծE׏Q03AtRPh20;)sdNT&}p"m˕(zchZ'YEI )뒦1/ Rryryry(9s3W/߀׍07äiD&Hfrwo80Y\|4핕!fg_$l.6kk)(Jb.| ذ,.ضEw?織r1+͕cDk`FPP(* C0S^۵v=2g}>c 2ɲ-[~BaYne VժT*ki54L.׋,a(ϗt}F_*J&qX"lu~\fr:/=6텿;| .y66i66@̙54߹Dzm{8_}evX\ȝw~Gƶ7e}"Yq̼Vk7|G?vov_RD>_T*~IRi6T*#AuDefO IժA: 9*)i#IAw9zEqj]]]|G&u3a{C^ ) \MP,Y 9t^LsG$juBE(T4m'0h4޽ȲG^Zdk`c_>y jJ߻XZ[cǁ[޽?¾}7Q6C}fؼ9dbb7ICa``qA1C<\gyJeEш0tXX0 r:￣-[h6BF FGߊCڠ՚VK^Aca,PZXVm۪Ubv֡PH8uy #z~߷Y^~Equt}=[bzbfN[- 8~ QUnw Xt :,k8vErmX{8pSE۷TysmF9yr,KTFh4FX284`fN!C(L;Ox^ ez Cuپk/b.dokwpqaLTZ\qiΝgq,%Gsט!n޵R֫_O垔ֲPqM ܾ[dc"bL:F:JCӪO$b|W.KT$m;K:j|.Gsw㘕e,Kҥ˝wt:k9 yGQU )8] (Od rb]~VkM DI,҉ ;TE!NSVV/85;at|,K.w8wQ\w0㠟&w0?+B_~k$vд"A:۶]K6 ຝY],k\nV}fAX5]M3?Q|ߡZmw:Z.i$6oY^^ɗ1M=tcR* 199BDf$ 4 *~ԧ~ܜ,wعMGo_U(b"8ǩ9("HoA~-[&SBQlr7sw$=+1\W 5R8FB,  =I!0LettS^t8"{IMF)JJ|("2>UOTJXn 䋽t\eӦ Ob]VWi~I*!I>50FEtbtt /Fz :Ы"MVkWrzȱcrW9"ӓk5b[n> re0__Cx_(ȲH8vvrZb&/ I2+!aA?:& ιs18|̞= vIӴp]WY0tg:39߾s@ RA%Y,YaR̬Tyv֬5j=f=,K%$(Q D tN7{remq0t:5 Qƶyj?IPmjމfp \&EdM;R(u]ƍ-(@CiU(ʟ}sitnX9 ϧbYB88&pMk8()Wyr~,+Lfz'mPQUNG>;wDؑ^% eddd2;Cde^z,FuN<$I(,[&0V~gz#n-FW/\;OE$ɑ#'0tj,.^"HP(d㬯zғ& I'4e. AבK.CkT%\_GXmJyrIZFlbQG_>oXX; R,$X_9D"1r)$I-`:{&Qn>f3 FR%mq2Mwc?G>$>~O~gX#i`:һT& a""t=1MC vBaD"G4H&׳P*|+gH)-?533w \eRHw^;F*l6Y[e}tzH$M( ٶA?=Ua^Cd)rHDG: rYXH43`H$z(^hW_I}I_*m||{Ft]*Z!#/yL V>z=lf('HI$2ۗؾw9ի"*ׯ7fD9e%|>[e QGt=&ޣG)$qt`WA e?ex{, &H$(sG]/2UГGHJ !A2Y"k]ܼ,BG&B*'Q/G8pnxR0cc(j4j5:Op+Ŵ] @QUDIܫi6TD4MDUM,K o~>޻!*(O%܁d,N@SEZ̭A,f=*ɻ;Qb87np82Mمm8CףVQf d2hB*Ubcj2Pi6u2zssd ~?P 3QǙy'G|7^  EF#:tWH=R!NQ[zSSbd!FFN?{dxbpp7y8`*uUW NS\0ܩ(vh6BY}}?`0D0dl%nmARy60.|m39EY(Ηd8wNĉG4g=wn@Uz=Ijfs~ [Pȓ sl.m{K7{ ܽlTOtnKsv`0H2vDEבmfõD"O8ga%¶ȲB*5]w ##)äR6"R@ 06 _gdӮ2X jX[j^l+}qfgرc w`˖q>xeb,>܀EU pyv\UB:H@0(6(xeq?+)^q%Mص+ܯ_'mDxJ50DB!e94!+_F IDATKF8NM3vbqB0&(6 knXHcyrH,cbl=VWO86^Um{4cJ1 |>R%Z-χyE`;NYGg\鬑{lUa{r4Йv-[30h4A$ca{|>b8`rQ^|тi pFk?E|.VZ UR"8|D" 8 RA(|=DQ`}*)m,ABdCssb):U5㌏{=ãd47%6BIeXԨĕ%qZO@c"Ķ b =ߜJ>p֢Gm06?1ΟwK痸1=}'O~;|>7o󼾁^{yG>?YR"bN<%128v s KLOOl!sDL=M6a` O!z82n}},#HeHert:  7-šQ,y啧pgA꠪"!LLN"O2YlLHY\DbvE.*IT*h OdYۦ.CBXRU׹8ci .8*P˲{8I# 7IdFQϳsAm֭۰.N}#GK"qLB0lr~ZX,ɝwg~؏|СGH$D"q>g47u#{yjʑ;G2B)1A`>WD q㬮JT*(J]7 <~.\xkB$ѳ-4ՓdeR<33J99wgjjkkFGܺuX@<&,2>~3]pT$# &q;t:$ZOhH$IeXm*\Az]lrI$"pS*L,zE,al,xVG*AIrd2e8k]&P( ݴ9{ߚ͓ yvdP<08ss/OfIRGX\A4x\P(J,`t0Mv[bq:fJ' `ni /fd2el۠нrMBr Hqq:^YQdXX"iNgk^eX[c ++7QU7qش i|>n||L6޽wp@Hq$I`v:FDU;Z]# NhE,Kce:mnIjsfZ$yTս;(JP(ijضaA44]s ]G4[_GI&ݞ,s{D]EUeE t{{N>ƶJCף4$C7##;I&\zp8fUT%@lv^/eOO3e Tlj15fshV SM}RedYѨsj燈FaFF, M% \eLLz^InoP'Oލؾ}|f77,-]7, 4,.^~k6@N&ӏePq;0Dl֭wpYQDl::b1YJ}}Du:St:5lA5lya)$X̱tT*Ǚ3O8%+:]8tP(ʾ}wrstnCfsv;hR)G&P,fR)ڢA^e۶cz4ml"[E4ME5鯬,n8N$:m~@2R){>)/|B;8,7زe|^O4k^AR$Eݮpă^²,E%EAi.=իg(I$.Kx OIG UU ]i4uEI yv|,>ih+ nŲd|>t[_ )nS~, ތKpՐ5~W3̿۵8vo}? j5R~>_%p{Uֺl052«7oRh6bضͫZɓc M"z|J*UĶ .9sW^bhh+0S}f"_jUeh4j\k׺t.̽T C.^>}-9y 89ik/RGu&lFS)ʉ+/nޤ)T}}t?e sb\{^8̃%^Ns\4J4$)Q4 Yx2+&ȱID]y"V83s|'Oލci&'p]N*رx !ߏMJ@>aX '(hM)akCd2/8֭KK$f7ܹӔc\ ^4OLfppW_=ç>kd29&&&Qn>EG1mQQhZ$aw._v2mxѴlkLOP2cc{uM̋vh6Wbppfslh4޽}|=&)ػnlc>tݡZ=cBsN{.& ]^N#JB(Bd#LqXVU>JK":fۼ\4F8 NӰDQ |bZd<8:ʎ\L8L,Dۚ(vz=~ǶLň㰦M0H\ؾA6ۥi8NwC:D@ V|i'?o"|`ppvҒ˥,b1$ h}ܸ$bbbѨ݇)^VeBS#OvK4ö4Mc ? HD"ReQ=a,,,x.W9l@:RSej6fgl($!B ;T `}e%C`p @<\1,O%ףf2W?`ZN|$œ 6ˢ eh5otMz"ܦRq]v|Q\k ?^x!pYϕJ͋h67~~x<fz d˖le4ox+x='PlC@nbY'N܉ϗEUi*`iw?k#-VWfo2o:4'n79{½'b|*@*E*fۥT( p=Zȴ T|uui #'1U(0L26_o`0D*f}׿9,ɭ[24 cHRwQ56ضXSFvqgt摤,* 0mcbqKضuERH DZiiMG_KDYKƲ9the ]wP8mKlz[c::LUET (L<$bY'/k<?w az$amdd4J<P!ǹzӴ0 +W=T|t//,4"0PߏeȊiI,՗@|k'd LLdbll47>p2ݰ9Y֩DdYgDZkks?ƾ}{9p Y DI^zOۡ/M*"O0kk71ME uZ*{MA,6He٨jMkyubf7uWXZ2;[[] "c\ex^FcUUP;'/".;io;F"ALMF|$H54ĠIt-p2o~;MJ$vd"&I}>dN&918H$cBNFD"$)r}t>i8 Bh¡CxӌpA"6XMmSSӬ̲m(D>'ˑϗoG0MIB _ݮR@ ۵PU i1۶ط$CC;pȑQ(T6n{R@6u;O=1I􀕕oɳP fݵKss  :@:&Тj2W4L`JqXyz)ب#n4n=$Xmfx'8ty/n=;3]t"u?/*14sHRi"lW{_)(Rݸ(Z-::_7~ig($c:rJzxbR|:Mq( Ljy|$B'?9 (\qYUmŶM( nɣG+45//invU|~7X^-$I fǎq Dh4_TMsvHiV1M MыkJ6++xʼnDLL&M 8|]z&9e˖#T* =mu7_fbv9t]48oyo躂$8~=v^|jMߴ͓D0qj fDa[r}y|T"A:`8m~?vKZE1 $ˢe:n=>1ur([y4h cV:BZky ]dmW%뛦Z]"ean%6y(I_(tv:-VWGeg& i4 ;rI$x=7V p;fT4uTUDUn>ÍmE6t.S,zJAjڔ`*p^7hhMM#NS$ x!,$>_D5dg" Vi|drrQ,BN TX XF,Keeev3Dw8NU!Dlj5O% BU )')f |9$Iƶm>_\./S,y/`*^mPn}7䩨*}`;F,p(`(/beڪP:Mkɶd4 uM㦢p-]eY Dà(g2ttQNqR) Ї>Osg{y `O4kN'g޷qD"qmal"* ?8M-Ջ(`kpQQ}>ZfH[Ȧa8.V6MZi]'rMl4:5Yf"srnEc j:%s)uG-rEFG'v8IrĥKS( Y\z3ݹRMS=Pr=yG4WnjUi67(g{I6;xb܍>6 ԩr˛ɑ[.:%04"/_zZI$/gC4KqP;{?h77uu}o#<‰طcr:aL8vy&6ϑrK%Ez4EnŰm~Q~)ux IDATQ( Zw  2۶︝3g^`aa}A(Bu66ܻHQ!Ȣi n]$x" s^EQ88NaYn? Ti4Av.D\p_*abC}I ͽwg bH b6$jg^xɃr*b%ϥRX܂$59ơCR.ƍ,+WG[6US$b1ҙ A~կOqHE".|Tàm*Wmh4ْϳpc^'H0wav:H&\xXMiU2zj]lFu$Iժ{M v˪xs%mM!{8~v:޽w ܺ[̠i+b1F">8x{>I RX]]&-2E0Ꚇ,(B[8|1nG0@P1 /I+DQ.o㩧?z ߲ͳmtDM08C[U,,[*˴t A~UdYB:bv5E^m;q*v1*אeysTn7Y]]ر߿$iû2L&ꪛ+bD*&O2w,`X4頨*"Xҥhc^d ZոCȲ8e߾x8gYb5i6ظ^7I>u+PI'0W|~|,pqH:D"f!LD_{|Qұ>`M;AP"쳏͒u``Ql_qmOY|Y__B(('X_wx@ >8(3Ƨ?ˌm!?'xӧyXq,p򶍵sYOO$FG9u H#?[{eʎ;xxwo!xO*X^;O26NzȇZ%ldeEpUVFG4@ A:P.HسgYHs$ih,SoGaz/?C1&w)t{NM ZMVVh6[|?C"AVVnq 'SS;k_?y-TIT q6^_$8[s}zjJ{-OD8!-1.^D2 :N<`h`m>7G}r-j*92I#fh4{/d2nvE r F%ޜti*>|7R9fg/!>6y?fd$KY#0?^7eLCT~E2{z4;E~?BU6d`&H|GٿLgFX]mz1j "4ퟵosO>퉾|>!.`4 p _`<$qֲVCV]WV th=(W^{U׫h4,0Ij(nιsŶm1,\ qcdr;'\M6f``D"͛Nqӯ_qm9}k@@"bin^A$V*b|٧yG%JF.D7᠍Fмʜ{\7ѼNr0z=ZMopNw{5b@%7uף{=nۨI2,o6.UIb-n./8N A谾LE۵Y]]"M t:-,ˠi'e;xmaYt]t}V~+r 9z.4Mcttry^"q dY$ ;ial&NaD1 ޏz=:ljD"8ZEQ 6&4M&'8 P3!Z7YuQ2(-]mȎîr<ٞ[Z"JQܵ7@qh6 ۦ8[R$jYȦd4UUA`M)rhM8b\fqQFwuaΜ9M4@BQds>| M3X[[# B7A7n*RwV( رNgI$J94`X\ll.8 =F<3眹vgvgwx)K%eɊe;ʍuVڴ5 i\hP$l׉S$jȉu9 I")}spm*X~Z`9~<3YYY5~,KEU<p1F4TM((]Ap;6׭B!JO>.yzƭDF(܉e|ӧ1, 8y|5'an$#h@X~{) Ue%@\L;- "N2iK$T:Vh!'SE ý>xmtiufJ<دkr"L&#lvP.׮mfGWдJQPeeeAvkm? ;:X(71UBQ,-b:uL#OBo74x^UG<äv, tMSGl^Ϝ!睨G(oU @miv:|'ȧRs9斗 iYV(O|Oyf֏?_uxbk_~rѢ!-[>;v|Z*Q/i lD"{LM H$ Q 狋 k *ibYѯ@Ӝ4 ]Qw.EJL:Ԇ/_(J R Ll6G<`iiNͳwm=oU}4Y4MJ>;`Fc1gyԁEaw#Driq/;FKQmV +#>}}ܖHpAؾuj8;7gDZ;vfttv[W~QHT*˾}={jզݮ1>\.$ >˷-t]]k6U.]:= e Iz&CzTe adfdHg2Ifw@W; (x٧(,{mm4<ܻ7umCBRWY^f0q)TPB\yej9YS>ZE0z~<,ܹ7xgEM W.}9 `T#>wLL`:m386olyae%<۴RE^6M a۶-RiҩUà/o=J^V#IDM.Eq8wM|t:J׻( iț4rdYʚ~t__T*繴M+br# ElۧՊ!I/HdϳOe˗c%T1g^}SS|dfuY8F,c.6ֆlǙ3gY~c^0H+HR~7B&ρ;9yr n}3\Z]qBF<(Hq׵0 `Y'IqtvNxb ׵4R `@nD,|'!"-8TULჹ3SQq0=>(8r.QvҺ]^B*f,YB)D큮u녟eqALLldÆI# `Z6/e{rw7 m17wMk-+9z5g߷Ns||#oBUW-k /|ﾋ۷q>e2Ue^gfbFu%gf 9AASL&YTFIzruQ.^D7MڎÂr-°,^qrzn d2xj kΗ}6^ wMMQ(rUش O33J xl=ͅsO=F+ _&Ff kX~=Cdz 파T02"^#СH>I͐*:f 0l|,+[Z…T 1T*d4wsC88OKp|b"A4&IQW*BJ ,$%Z*!: " r]i(ZHAp FZ-4Ml# Q;b(lΟ=,K8Yqy2/B& .|1~ 3g^@UWI$@ojkU17'!GZC &˘z=VWLl57冯-m( <:6;#>qnO&&byY޹&Ν\Z +l;r =]EA4 NĵmE~yA8w,#!IahP(JlT*͇?<:~'^o:hZJm[vKӴ.v{'JDcZVjұc7|nm:vm؀,d 5btDb.G̶1}rc*"||:M*1337zR̦I(}Ű;q,qzJ0*OI E,G@nh:76bk126)-o?(JHR<$0Tb$ɵFڤ'^ӾVql[qo؀f؞GT".xO4Y4 ^u/UخKq]t$,%>vl:8 ,ˤiA`$/re,ۦn`UXH]UTC"`d׵y`F ^pid6TJxO {OEuv哟|Feߣ٬Fs1ӯgn[.x ϣ(It)͝2, t%r*LhaѼ Xm39Kp;dY(̶A'CuY\ZBQ2wpU}p?_{Io8 'NDUb~(""[a~Q٤٬XĩW1Ao/192B6ܶuw_OBH"qI}nx,F c1^cvzz= @>˵ZL-غy3׭c``D2ɳ/͛73<<̟m [tڍ[&'.)TFFxS[7ٳg(ϗ)ʤRyD1Nԧ Yغu py|R@*ZQ'H`*߾KSeCt@8zkٍc1uB+I$q S,Q*c6c׮YuⲌ\=?|33[Zϛo4/344AXabbl6R Tٲjy#lm]g9( 9s˫<ﾋ;-m]Ǒwz;6?|ЫrϾ}.dH&h*Ait<N8Adr9bA1~}$("L( !1tR9b1˗}d9IDi"#s.]E i'TX:FT4{qK{w=lTxNU:5soAq 2f۶v;d22k!nZccS׮]#i2:K SO/Xr|Q -, uiX 'i\YZv]:=LCQ?OIDATf{^>|m=Ow]1 O*CC*45n`DvC]]Ax^g>x:{3AJAhR8,-CA`D5 24 P[8c&N㒠Z]Ylny.KKWf8d$ IBw@A}b>17xٻs'3 Q.^"LL QBt3w鿻9+~<7E^ $?_LfIENDB`move=1000;blend=1000;3DR3  Q    I%U0t1x.ţ0HҔ)IJ)J׵#F#B1"JvL'0pL(Wfff+rvy;e;O2woY{NsF`4 B]#8j8. `]΄QD, XBt ^#KJL)d):.UQHzd 4"BbbCG (yBE B8 \ 0pq"N,Xb =3L$a.@9˺4eIҔ)JJiѥyT}€XZ F4b]EYEbYe]v,]s QMI*ՙ`*= *T 4pƉ.D *Xĉ,d,LQQS *aUTI&&VQURc:s1i!Fs9ЃK״aEtAfֵ2dQ1QÌ,XHh&=4HBYy-',2UucH 'l|zwww]۾h( @B@&wr ffd/<ڣY̽w7+mFw77+QEֽVRTe)ډVܕoھ7֨Ń̝kZ^,E}kW*T*"QQ}wkyFyy'{}rw{N֝:_eHƑ F eW]ecEI$kZVj(5%Tct#,jf#F+B4q9HҔZ68R,$ᡡᡡh  &!/3`ŵH:fLqfH VĤ,VN"-\3F'Jl)H( ˋHX b}3EGGF  ΊJifd@`8B0bR@x|p"v) dᡀP'\}X`5TX6m^yej0'Thɫ) $˕fq36/TS'yKZ>*(Z}Z1bN9iK@/l%Ċq }c_ub 4A'_p CD,Xm3<\Lx"ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 13DR3B19\\ ,  )))  ,JXN:<`) 22UOH1Ǔ!8uӧR( *y1eTUU2Bm6A:AQFeXaee]faQ (2TiŒ(Q. , %B5B@l xĢq tF8TO M%,lF )''T@ \8lR*p⧐)$'(") 4`ٲLLxǏLdP$BҩJ*CeiePD H4(̞UT ,DNPD2NDJPJPPD2XcȈʌ Hr9Ax<4-GD$# `pH$ 0p|B!BPl  X<"  $$'*DTR"ĥ%6Jdѣ(*eLHCR!@p*PD#) ", PT: E€&)AHR V..Ed !0|4% HA0x$QHhV !dEcaA $"X4+caXhl>b|>66 p0 CP& l.hAT& P* . @tT#@L& D"P0 PpH D,%Iʔ4hUS8pM,hcF 84""AHL @( &A8D%ĢД b(CbAqpdJ6%@ tL*#Ã4<44RR'%,@HTH@T@he2V]Yi+M4뮺2->]cϴ\LN@ !iOM( 2҉P%B3ɋLdULy2)|21Ƀe>,LLQ c'O*e2:s*N@TD"!aa\r\˗&>,|L1>0itQ>]ug`U@8L 0( ,@8ptXcˬL|\l1ˮrd(M,봻K25Y\Y+L)Ap QF"Bө&$@p a)U2b3fJG8B H  TM8Q*6pf̦HN- "!\:T P!` tC%I H ţTd < `)F͖#8dM2: %J|Tj#F C a*!:`8@0#,2PFH,3aJfie]v>K}*4 u@t]faXa(\kK4,4)THXi,.]&JeeZes$i0,44Ra,XdNFF%`LQeд뮱tK>φp\Yve ˬs0@0l .\X %``.LLL\KPK3̣Q*aFe]fPFB P@dTʩLɃʜ#0IK#%#" $''$)$*HNH@@R@RT R9 bSETɂLTA)H$" pO&Ld948Â`hP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&m@[ fQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JpDubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac110ubinding site for residue na a 336ac2  10~binding site for residue mlt a 337ac3 4 10ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11H ubinding site for residue na a 336ac2  1H ~binding site for residue mlt a 337ac3 4 1H ubinding site for residue na a 335ac11 ubinding site for residue na a 336ac2  1 ~binding site for residue mlt a 337ac3 4 1 ?333333?333333?333333???????@???tldt$=?M@`@|D@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition)PNG  IHDRc IDATxyxTE?;!!` """;sf_uq"M@TW\ ePAeQPd",Qİ#8,ǩN/}ӡ;3>y޺Uu=}Y,@C+CE!n1OF!ny' q4Cƙg,́;`mpN,סa*!|+h7&gddЪA~Ł]8P\Lp8y&O$z~ FE YO[;GσWGr5x.vz lk> |CEa6@S p \tN;Q)#T8rɔ8 $EÎ: _؉0ԁd–?ZU&BMKsեrE )kRdgM37fJyFu]K^A>qR_XdM LDk ρ?fwXYY2Pg1ȶ俘@'Yƃ)T.կ/nG C#̋ϒrRœEnYz CF餼>v _+zYdS,ad]_RRݑ7̲&*uAX,a q_\ə\wEcPEOʀN0/jcS',JKgG)EXtJvL )Pj+b۞~ nmwuSiIiTU?a͟n i_M 5&f䃼jr ?9)mF~>la2S7 xciL8^߮.貙PWFa$ tL!iogovm+;:ya5oUa;nf{ЩV~^dGzӓ2'|ڲv3ϔ o|9ز.)8y٦lS>J{[Ha%n"]-1Ɉss̤iys/`Yt~:Z 4})GM.^NgqbHMҚ?2eqLdr 9kT-z(Μ~&;o$c@Gq7ϖt>OY/vSvQY'Хjۄ7,X a"HDΚuwTk:Es]d7fG8.~DE^:? (++SK`rL$}|d.{5Q7_4yLd9nMSa«#2䩐r^Cxؐg`JLE[@ǵ7"{^5vf2&[4/uaXi6< ATv&baAX# >7AWO ̱шkDݢ)@&z1/"_m{5( l;M퉓c*Oct$&wDW/$Ssj{@&pd-X 3mlP A>qR S@&[Ν'AvU밯eofΖ#MT C0 z&+A^00y=ed_r'b`jEw3l [A D 4A?63#rP;( |΅<@s)8C"`>qv'|]ڨ+EE Fk ~Ը1gUPY1Go7%Q8bp^8_W}y2Lx2N 13'\`U/ hf51>> nm@UJY2,p0{v4޽ ^0 }NEFsBi8}h_V+j bW7"Ky@koחْA&gu?4\PWL6 B`{(|v ܉L^7~.Vۆ-&jko/JPs1ElTsS,I:N~-wka7\M\Tt0c1(_B^/V=6+%U`aYTl` N&8mfy s*SmLmN!s0a$HAW^#Z8tMs  =l’Kb/Z:ch? pk5CfS]O1taL^/^T*͒c6#Yk PENvu,9|B?qnroe@uA(DRuվ< 6Cs/z)4/D|K13ns%DtGAoͱ-˦)_^/GrTx/G`&0j ~.C{Q) bE7"`:y LߍJDuMBA%m9¯Lp):`,B a p*"!\\uJvaԟW?uSP3I2uTceM3dwhG7i'Ͽ *ECa~:[seڽa#A1&SUQ+=]2>ʐ6xTAbZm$Xa6~i|#iid/C{ ȁ&0NX _/r :\Όpރlw|$Qjyy3k% A2F8k@vH@a^M\;\@H֦/H6n"VJ@Ή&!fxPmqt>rҦ-; ;O|DWS´6Dӎc'q\b9qډa5{\rM$tԼ'hzg=U\.׿\T|SߡKt>עfȺ5x_?'JF` r~E_L+_pqTt=- UM;q*q>2y!kV0o5쏲O _(puDcW4)`ƥ0j!)kHއǶ4zw/z+ǣOЫ 3y#8DԤܔ; J4o }"V=_e0e sc4G:t!א }Qܼ9GNb8n F{XM{yyZU?Oj9J،+l@tw0=>Z:*DMEl]xA}m_ڰam(P(le{:{ P|KQi1"@w_m~"{QUsA St4ԼK04l3 @4^XXc@%Έ(e/ђދƠgt?3תMK.[wh7y9FԔjƧ%5e/ ۪}A6O\\T\4:O>lQⱃuEŞ01u^/xK]c aoQQ˓ _ 1n`i ) IRƻ4^ ֲo>g a2/L]MV4=b@X <|Rwl2#rv&&c_6c %2SV\FZ4~_7<kh SU'|Ldg5T FjxaG0+`G8i`+t^Fj"yN1 ERʷKee`M[C`OXs{pܾѡi 0Ocp`\5 G+h\=4(b8t3n? cA҇*tf'zbwN5q=?6n7F_P0FB8<4s+,3nHRO VB̀i'pk!p3GU۰ĝ[&FIK1pZWG>5\8@j10n.vR>K0o{p5<;{r¿>is]V3fvE ŝpQihȇ3 `.8 }j1gW G='6Ib\*3裧*\.~}# 8`J~ MD˸u̲x*>gG]r]b6V<l9sz7P\٭ ,K>wd)jHmmA5ioHj 6}z CDHD^ȿL WL?B =|x=4RG샻'k2?w:LPm0ʃ{ᇹpҽPD'9.qQfb.ӦKλ.kbYEY@+y, WcuNЕ] qAk3)%>h~m;D{ B֕{ܸq< TtÇbӀ0g2J7k bg*ΊZ2E))$ .sDP2trSP&ah):6,\.i4Ҭ4V'6|ӏ}ʕ5ҝ0}s2P  :ڌ*iN@J0@if[}wG*.@ Uߧw>XEc228Fۭr^Z=\!KP22ˠ̔SWAª&¡:$\ ~06Ӂ]Ö/n]oܥ(ד[a{EYx|Ts* LstG0pr,a駓ysyvQ&j\̿J,yG%xt|M_Rc*s>| W/9՛24Au>ŀac IDAT9fx?ѱ䐝iu=* a%>at2HGXw!B[+A_4=7-{ѐRSN##ԇŰӽPu H%}̱ǐMQR Ac[dڭ;dv~0: S$*}'WR(FLFXMeL9` = V b }{Wؐj͋tw%Z~_V]?7NX6TP05{~*.w w{u2 U*8AJI "w36(9E%EQ|$~x8aCA?D.Cn#n1 uAy&;Fç?Y^f();.з @C|`h5*&8eas=Ho [#r[.u9 0^H|{6Md[̽3b"Ng[Z,j^gίވ{[=o0Q, T_27eFo߃|/=K $N'5n=@V[i͸yQKi.uڧQ>rAA܏= MVG)9R/Y:ᨀF`Ϯ]|AxJT@n3:e=DopQQ<Bg!m(µ+}1⨥ȧ~PE\ɋs: .ݨoj{~d*9;Ls un 52 _΄"k> B߂M^ox U%Tx z#/+< _F8l|Hi%sKE>Y0)܆0冠!{;ֆ0##1r0u  r2֐:\c~_i_g:Kiu+nBD DƘ8С5^fOk( t3w |+j4{E+gkQ xф>49!7Hٖ'MHҍT5h?q1h}Ar(@}|z`P9z 4̎&j'a6'[9@&)6U0^|Dv[+P5{n<: aȗ\pﳳϠ6r`_f3fMD2`Fy&t'h764=r+6mU.#b!lO]QD2Y&P@WuGEwE 7Bc&@#u'IX7#ic$µ'jQLE7;d?`JzK(剨-tFegyќF 4aE%Rwqn"Fx~WtRi+# ԣspJy;ܹ6IIuRwҟMxJzR%YDw *CJIn+mmLܓSYDu7N&'BJEcntK Pв%Ycl <ڿFJ*H:" PD Cν;:ɓ$dY\HHBku̓DxQr`br꘧qNSQHBYy-',2UucH 'l|zwww]۾h( @B@&wr ffd/<ڣY̽w7+mFw77+QEֽVRTe)ډVܕoھ7֨Ń̝kZ^,E}kW*T*"QQ}wkyFyy'{}rw{N֝:_eHƑ F eW]ecEI$kZVj(5%Tct#,jf#F+B4q9HҔZ68R,$ᡡᡡh 44ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 13DR3B1N.\\,  )))  ,JXN:<`) 22UOH1Ǔ!8uӧR( *y1eTUU2Bm6A:AQFeXaee]faQ (2TiŒ(Q. , %B5B@l xĢq tF8TO M%,lF )''T@ \8lR*p⧐)$'(") 4`ٲLLxǏLdP$BҩJ*CeiePD H4(̞UT ,DNPD2NDJPJPPD2XcȈʌ Hr9Ax<4-GD$# `pH$ 0p|B!BPl  X<"  $$'*DTR"ĥ%6Jdѣ(*eLHCR!@p*PD#) ", PT: E€&)AHR V..Ed !0|4% HA0x$QHhV !dEcaA $"X4+caXhl>b|>66 p0 CP& l.hAT& P* . @tT#@L& D"P0 PpH D,%Iʔ4hUS8pM,hcF 84""AHL @( &A8D%ĢД b(CbAqpdJ6%@ tL*#Ã4<44RR'%,@HTH@T@he2V]Yi+M4뮺2->]cϴ\LN@ !iOM( 2҉P%B3ɋLdULy2)|21Ƀe>,LLQ c'O*e2:s*N@TD"!aa\r\˗&>,|L1>0itQ>]ug`U@8L 0( ,@8ptXcˬL|\l1ˮrd(M,봻K25Y\Y+L)Ap QF"Bө&$@p a)U2b3fJG8B H  TM8Q*6pf̦HN- "!\:T P!` tC%I H ţTd < `)F͖#8dM2: %J|Tj#F C a*!:`8@0#,2PFH,3aJfie]v>K}*4 u@t]faXa(\kK4,4)THXi,.]&JeeZes$i0,44Ra,XdNFF%`LQeд뮱tK>φp\Yve ˬs0@0l .\X %``.LLL\KPK3̣Q*aFe]fPFB P@dTʩLɃʜ#0IK#%#" $''$)$*HNH@@R@RT R9 bSETɂLTA)H$" pO&Ld948Â`hP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&m@[ fQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JpDubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac110ubinding site for residue na a 336ac2  10~binding site for residue mlt a 337ac3 4 10ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11H ubinding site for residue na a 336ac2  1H ~binding site for residue mlt a 337ac3 4 1H ubinding site for residue na a 335ac11 ubinding site for residue na a 336ac2  1 ~binding site for residue mlt a 337ac3 4 1 2G17    ZZ_UjGUTTW]j#j֨5֢[UjZZO$HI$$I $BI!$O vbinding site for residue so4 a 401ac11~binding site for residue so4 a 402ac2Uj 1vbinding site for residue so4 a 403ac3KL1vbinding site for residue so4 a 404ac41~binding site for residue so4 a 405ac5 1~binding site for residue so4 a 406ac6in 1vbinding site for residue so4 a 407ac71vbinding site for residue so4 a 408ac881vbinding site for residue so4 a 409ac91vbinding site for residue so4 a 410bc11met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESBB1?333333?333333?333333???????@??+2G17AfffL?p}-+3DR3Afff333?p}0?rr$??lBBK2?E?E?E??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10PNG  IHDRc IDATxw|my&ًB $ $P*ehi)﷥4PFP[hY-  $$d!YN$YY?Y;^|^ǒ?_K1!<]4OQ&OaHxP[HBev(1#O`hD$!v _<]IA.#O1`<"I2;}_'BVwkt,ˢ7z&O!{t 1G 0u|垮Wap8,&A/~EVUQPU B>$IA IH(_VMw2 ̚a'a&!PU/|k=CT0C\4qE[UDJ|̚|Ym/2RrAE-# KLK !ӾIfzHŞg(KuyZүߖ0mȲBXg[μP8$IHBF$IKgy#({i}ʑx뫸jaCN$'cu=`,Bax$Ӗ,~Ssoé&zYޣ_A]}%G|{Ϛ|\μiW\XcƄ%n # f1Pz4=5+_Kv=)?tu,|";p%0p s\@ú(XHE&_e6_?uШ+RR3jaɚܿ)X@IE{=EvJfɗ pt'y#"Dt=_˖E@NK^&}p#ndh8>)(jW ϼ/aW+{Ȯ=$vMWǢ df95n*Wv4iA>vÝo/-M"/@=麡q텿DddYa޵|QphZMWxq A$0}{$aGzNX 2.-CjG>ɣuxխq4gꕀ}BUŁ,3o?)PI[ҦznOC[__C(o1@>5&$̘pq~o3!忤'kP8?;nj94΍1r4*kz 2S6t=L+%n2>PKMi}ry4ܩWAr[O[bg<0`=ś[%0N5!a[ Uוa[ӆjòLxy۽qɃǽ8( wt@sM%Ǵ Ӳwnjc)O axt(7ކgyoC.ְr?}!y;g<,y"!foׁ"4ib&\q:e"ljTwk{WZ~;/m3O@ Eub5v$$ɘ^?&>{y?m-̙z9s^"1U =i1 CQy?ngO]Hr8%]wYBc _}ps8V} >}Ϳ%"67"(@K 7;FǩAH tYȫuG@ r#GF_'h}m7|䥱U;JS-S/PsZ9UHNGB.봳hlb~s#L^crߣ+kCy$nA4JSY{jO)a-v@_! H²嗢{{w/t0#G¶H~)|{cƍ̟?rr(rrb"g[RVoۏ;'6 In<ΐ}p?yǦÚwc=ĉm핕veZy3n7pm=9#Ex+@o} upcgl3ļiW[526|Vt ?.~ ,N{=y⢋.K/eԨQ(F:TGѐ!LU\|فQ~iĝea'DyFl/۩-&jpƸŜ1n1ܭAS"qmT8G~۝3!!69j@7ۋ>`v*qŹ?f AoapI| ?! %عC[vPMJJ@ULlR3j:BZ$R9̛Hpw;69TBF 9YٶkuJ]h0TŁ,?{Nwz3YV0M]1Lx )"ʪp?¢>PG P&B+tO` gdxJYg:#L%Zi'<\qjcAX yǪ K+ebwH!ݟW?}\0_đg$$BZ'_=;@,wa#p:-ZymŔS*N4NO=ARQ{5%-)CE@ɗFU]toP. eXr&K*8 ´Ln~ލ+^yf=a)HIˢ>Xą/xʨ.&51TBdaa3|Z|Z;xЇ_R -9snU:DW2$ctӀԙ2Rs1M`֝VVe 4W$]6YEWQYw]wC-9p*B,>}ͬɗ! к- Ju] iژ~ x;o@9P%ՅˑDZrx 1!YRк1Tdݺ%-?}E$FvzcjDwgjQ␸"vHEu1>-z`[d% ]WNxg?Y'5BfZWuu4l |x҇_ZVLvK?b.Ņfջ&ggM0 .S*(I $rR({b8.BH*ۇN(G* KdWKtv{H"+ $l,VUhoiw}wme}?2O_"B>Jɳ[!d)ER#-B_EJf޿SM.o޲e Y쵶5~ 1-#E1y.d ƻfc.9_TWWOkcp2٤1qb!Y q1lX&|p163xѬr&ZzN:̛vutxkMoĉCٱ )_psyUl\%socml7xS8Tqs>N$&0Lte奲~9B%|\qR;F>vk|5D#5ݞɵ9:!O|{񯱰씲vlv`{}Ktg݌˙$d2Rs1L41M40L 1L| x` ; YR{5ﴫ3MUq u(qʏ^n4Οi}#DѩV MXˑI`gdAШ\w d S\Kb'`̙Θ1',.. ܊{]_?P O}5p=IvBP8@}&_4eGTY4vCKQ!&=z4rJ ҧO$I^JY=zqZKކJUQ)40lig殞!a44-tEah M`~)</v ̙39`Y':E:5OSIjRizy>jYEp_dlgi&&LN*2,aǾOI,b>=LҐ$5[^9S04|JSV}Մ&>ٶm[sEhz*mEdK8i $b'v̜ !/u)*³(eZTۂ1fb*|{9 "crϲQ[6L}SG/믦WAFbp}]}ٲe^ kA,"g68ۗӇ/Ho SGm=ݢ1-0ΤIPY9sILL?aJ6>UqCh|G\ \ |xm|߿iӦK)\0wJ./C&cZ;M7ĉYz5\s s̉'4"\  !91h| n^۷/ӧOo@% 4 =6?\z -ЙSLap ,]ٳgJĎaE O+-Ӽj*=gE,^MӨdڵ\(5h }OĨANJbF<*~rAn&y睘^ 04 -LrҥȲ,qNXv-kA!/`u`Qu l߻6fΞ=ϔ)S8Ӹ"s2p9HIr^;l=ܱG- oD<ũ&7g>m~VG1edYFUU/^̭DҘJ%W3|d򳇒/_4=qʠ}HK"+=wu>]0k,f!8  S竌3`)9 IK⹷;üy:O1e ;C[, OsOfu>ӟ:|}! 0 `؏M"[WEX Fmϛ7m۶u>Z´1ǥݖ6g$wxePs<3"|N(믥j?u/*BZosyw;=&_1n,cn[PCuii!Q^}0UUUqv_*NLӰC+ژ릢$7 Ht0a\VWT餥dNp&S+ex(I#;^{Q-C,]@0VeZc19&@įsO7o> ƑNVz>ٸs)$8w}c/$ ւ{,GYu~bv-A huH睝[ P'ϼ @ !ITV-+bҹ¢ s=G7GvIBn7۟xK4aY2 7No~YG/l툂@UY0hR!$#I2?v(_XooH/$d%*ӑHRB*y,=X^sU{ ѤMW__dIcln>C>L~8`E5x:&;ٷ- ^iλ'b GdYA6UaˮBxB):Ժ*.\DHK³nFYyqx@HEe+ۂ38%K0sL{19w:~_1iҤd$,&aA<.8[#1$YdPlI1 maW7t>Q[!;OADRIIr";$ﵞyԐ3hz(.5_Whj˗bŊ [_`curHF~LUŴ,^V|p8\i$'fN#5M+YVmD[XB~BZ)#VXւ63Rd(k,dHF~0$'fK$=z5N9`ȇiY\uL1~.W^y_~L8Ɉb!H#^{4s$`gk}[gzy5p)$IJHHLƮn/XjP}e)HEu3m~⨩અ6%w~<sDa ⌎BB4#lolCޥSg>G4y ?3ryTUŝAFTu7l8| >(wݱ^(3_ՉM sO>Jqm Cò0,e]˘ \Z)+ǟ9.,8֋ܙn23d3ᦘOЧO֬YÆ NLR$dfа#&z֛x"%1`hɗ_ozRXw]~104KϽw8p#RVQҪbĀ ?ִ=>h}Ev 3(q$! 'W,_AȰ0lx6J3Q 7?*bJK!4=| ϼ+fyIDAT&/;RtZkHBп({jmZr' _@qD%5_xu/,SRr8fhϡ9x*ibf̾ic/GI /ND(  SgԠiXX+1( _,m Lo;n"v5_}H/Vl]5, P=?#`HxjQ^}X`Y&5R\'(,BARIJs6ȦH `m a'WU+.ABb_ Tp р72,2P^M~%e0Qqc4 J9\}ԕւ#n*:/::u/soN\OFc:igN G,$YEVj)* z?j(Q5 ~ԍ;|{% 8\W u49gh|U#XV(KGGA #>< MZd|?`uҮaZ/<Fc:J-r݅JGU?&L0iȎ8t&M=-|z^k3 !eq"r6A'eYNIM¡:##Qql K~`Ԉns\n葤a ]C3 7IԹ3n {t0ucg@Q(Ӷ5ZDokms=6gxM[iw=^yqqh`>6>*jQY{8j'{%,"_=myg-DӃElIfg$LՈC&IQV4=h+v:OE4TU)Rj:R#pD 7k8et$ Ir]$%UqQ)t{a=HJb:51iR\Ԥ̨dY=č ^ZD*!I[6|E0 T*kN;jizó$5MfZ_z1me!$ˢ5Qنf<Hӑ&MˊdX㑊K;y*(b۞Z83TA(o|'d "#= Ojv}0HR~yãihF8쑹cD74`DV D)9e$9fQ74FyM1gNOH t$pÒ?nҖahQcC_W!#5g2ehzQEX Di"E|7 8 av#N EkC(.II^|!1a Feӎ$q8LL')h3 p.L@Ӄ SrM-⒰+M@Umz]S,+xꫢyM` lj%%{)>˙d2nMicڇeq eg Ir]Q]WbOIG!zضG,9B @+V5uثcQ\IUq2p#yomn,K NGyY0 30vv b1MG$?ghgik9\.[BQ*EEQY8i%>pn<\rΏ۾hЍp\ӀVO717#%!㩏bҨsдHQ# K*.,˲7iv "kNFRBpCvQܐ=śٱSR-"/k }0rd%IJ$Pkv FO[.j0@ilޱmϘp1$y*3QHEqj-{:jj ,Gfz>;+J)tٓiXH\y=5 믡՞bk3Zo%?{IR;d$w9C?q.hy{{z$y.i!JjR&m}ug@{;o"$(I^@2La  Wiд`\-@485RAϠSX`pd(*ފ.q䭯YVSMDUN^4zd-ء3=t&vnr;5UueQYw8.Og[HOΊh ӿuNrnVowag! ',3_8UQQ;Zj? 1mQ%7~@߬ Sggk7?n>?i\0icݵO! āSg$٫7ʝO}5^-i')$'(") 4`ٲLLxǏLdP$BҩJ*CeiePD H4(̞UT ,DNPD2NDJPJPPD2XcȈʌ Hr9Ax<4-GD$# `pH$ 0p|B!BPl  X<"  $$'*DTR"ĥ%6Jdѣ(*eLHCR!@p*PD#) ", PT: E€&)AHR V..Ed !0|4% HA0x$QHhV !dEcaA $"X4+caXhl>b|>66 p0 CP& l.hAT& P* . @tT#@L& D"P0 PpH D,%Iʔ4hUS8pM,hcF 84""AHL @( &A8D%ĢД b(CbAqpdJ6%@ tL*#Ã4<44RR'%,@HTH@T@he2V]Yi+M4뮺2->]cϴ\LN@ !iOM( 2҉P%B3ɋLdULy2)|21Ƀe>,LLQ c'O*e2:s*N@TD"!aa\r\˗&>,|L1>0itQ>]ug`U@8L 0( ,@8ptXcˬL|\l1ˮrd(M,봻K25Y\Y+L)Ap QF"Bө&$@p a)U2b3fJG8B H  TM8Q*6pf̦HN- "!\:T P!` tC%I H ţTd < `)F͖#8dM2: %J|Tj#F C a*!:`8@0#,2PFH,3aJfie]v>K}*4 u@t]faXa(\kK4,4)THXi,.]&JeeZes$i0,44Ra,XdNFF%`LQeд뮱tK>φp\Yve ˬs0@0l .\X %``.LLL\KPK3̣Q*aFe]fPFB P@dTʩLɃʜ#0IK#%#" $''$)$*HNH@@R@RT R9 bSETɂLTA)H$" pO&Ld948Â`hP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&mwwwowm?ӻw{twwtwm?wwP(Dm&D&m@[ fQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JQI$I$URI$!UTDEB"*I$I$UU$I*$HI*"*I$I$UUQ!BBU$I$"""*I$I$UB*$I$DDERI$I%DDDDEUTIBUB*I$I%DDUUI$JI$"JI$I$UTDDEB!DEUI$I*""""I$I* UP! """""""*I$I$TI$IQUU$BUDDP! ""I$IQURI$I$$"I$I%UUB*!QURI$J"""I$JT!BI$I*DDDU$I$TDDDDUUI$!UQ!B$I$TDEUTI$I"*I$$I$IUUDDDP! BDUTI$"""*$I$"UB"""*""""I$JpDubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac110ubinding site for residue na a 336ac2  10~binding site for residue mlt a 337ac3 4 10ubinding site for residue na a 335ac11ubinding site for residue na a 336ac2  1~binding site for residue mlt a 337ac3 4 1ubinding site for residue na a 335ac11H ubinding site for residue na a 336ac2  1H ~binding site for residue mlt a 337ac3 4 1H ubinding site for residue na a 335ac11 ubinding site for residue na a 336ac2  1 ~binding site for residue mlt a 337ac3 4 1 2G17    ZZ_UjGUTTW]j#j֨5֢[UjZZO$HI$$I $BI!$O vbinding site for residue so4 a 401ac11~binding site for residue so4 a 402ac2Uj 1vbinding site for residue so4 a 403ac3KL1vbinding site for residue so4 a 404ac41~binding site for residue so4 a 405ac5 1~binding site for residue so4 a 406ac6in 1vbinding site for residue so4 a 407ac71vbinding site for residue so4 a 408ac881vbinding site for residue so4 a 409ac91vbinding site for residue so4 a 410bc11met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESBB1?333333?333333?333333???????@???OAMLNTLIVGASGYAGAELVTYVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVELPLQPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLEAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGILETITCRLKSGVTQAQVAQALQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQCANIRFGYAETQSLIn-acetyl-gamma-glutamyl-phosphate reductase; chain: a; synonym: agpr, n-acetyl-glutamate semialdehyde dehydrogenase, nagsa dehydrogenase; ec: 1.2.1.38; engineered: yesP__EEEEEE____HHHHHHHHHHHH___EEE_EEEEE________BHHHH_GGG______BEEEE__GGG______EEEE___HHHHHHHHHHHHH___EEEE_________HHHHHHH_______HHHHHH_EE_______HHHH___EEE___HHHHHHHHHHHHHHH___B______EEEEEE_GGGG_________GGG___EE_______HHHHHHHHH____EEEEEE______EEEEEEEEB_____HHHHHHHHHHHH_____EEE_______GGG______EEEEEEEE__EEEEEEEE___IIIIIHHHHHHHHHHH_________P____________F_________F_F__F_______________________F____________________________________________________________________________________________________________________________________________________F___________________________________FF__________________________F__F_____________FF__________________________F_________________________"binding site for residue na a 335ac1 F"binding site for residue na a 336  ac2F#binding site for residue mlt a 337 4ac30F#binding site for residue mlt a 3376ac3FQSNAMLNTLIVGASGYAGAELVSYVNRHPHMTITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDVRDFSADVDVVFLATAHEVSHDLAPQFLQAGCVVFDLSGAFRVNDRAFYEKYYGFTHQYPELLEQAVYGLAEWNVDKLNTANLIAVPGCYPTAAQLSLKPLIDGGLLDLTQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIAVHLGAEVIFTPHLGNFPRGILETITCRLKAGVTHAQVADVLQKAYGDKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIVVATEDNLLKGAAAQAVQCANIRFGFAETQSLIn-acetyl-gamma-glutamyl-phosphate reductase; chain: a; synonym: agpr, n- acetyl-glutamate semialdehyde dehydrogenase, nagsa dehydrogenase; ec: 1.2.1.38; engineered: yesR____EEEEEE___HHHHHHHHHHHHHH__EEEEEEEEE________HHHHHHGGGG______EEEE_GGGGG_____EEEE__HHHHHHHHHHHHHHH__EEEE________HHHHHHHHHH____HHHHHHHHEE_GGGGHHHHHH___EEE__HHHHHHHHHHHHHHHHH_________EEEEEE_GGGGG_______GGGGG_EEE______HHHHHHHHHHH___EEEEEEE_____EEEEEEEE_____HHHHHHHHHHHHHH____EEE______GGGGG_____EEEEEEEE__EEEEEEEE______HHHHHHHHHHHHHH________R___F_________________________FF________________________F_________p__________________F___________________FFF__F__________F__________________F__F____________FF_________________________________F__________________F____FF_____________________________________________________F____F_FF___________________________________________________________#binding site for residue so4 a 401ac1 F#binding site for residue so4 a 402Ujkyac20F#binding site for residue so4 a 402ac2F#binding site for residue so4 a 403KLac3F#binding site for residue so4 a 404ac4 F#binding site for residue so4 a 405ac5 F#binding site for residue so4 a 405ac5F#binding site for residue so4 a 406inac60F#binding site for residue so4 a 406ac6F#binding site for residue so4 a 407ac7F#binding site for residue so4 a 4088ac8F#binding site for residue so4 a 409ac9F#binding site for residue so4 a 410bc1F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine BBMOD_RESpQ3DR3_a2G17_a  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMN  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOP@Ѭ0K;]@n-acetyl-gamma-glutamyl-phosphate reductase; chain: a; synonym: agpr, n-acetyl-glutamate semialdehyde dehydrogenase, nagsa dehydrogenase; ec: 1.2.1.38; engineered: yes3DR33dr3 P 62 2 2 BBB??@ a???@MS"`B@Ye^ s??z?z?C>FIm?z@MS"`Bz@Ye^ sC>FIm???@MS"`B@Ye^ s?????z?z?C>FIm AMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW aa3DR3_aali_out ff fffff ffffffffffffff ffffff ffff fffffffffffff ffffffff fffffffffff fffffffff fffffffff fffff fffffffff fffffffffff ff ffffffffffffff aana'(aana2'aamltj =@  _ala =@?ACD@BA@E  _ser AEDFHJEGFEIHK  _glyFKJLNKMLO  Htyr LONPRZOQPOSRTUSVSWTXUXVWYX[  Hala P[Z\^_[]\[` Hgly\`_ac`bad Hala adceghdfedi Hglu eihjlqikjimlnmopnnr Hleujrqsuyrtsrvuwxvvz Hvalszy{}z|{z~}} Hthr{ Htyr  Hval Hasn Harg  _his  _pro _his  Emet Easn Eile _thr Eala  Eleu! Ethr" Eval# Eser  $ _ala         % _gln   & _ser ' _asn $! "#!!%( _asp%$&(,%'&%)(*+))-) _ala &-,.01-/.-2* _gly.21352436+ _lys 36579>6876:9;:<;=<?, Bleu7?>@BF?A@?CBDECCG- Hile@GFHJNGIHGKLJMJKO. Hser HONPRTOQPOSRU/ HaspPUTVX\UWVUYXZ[YY]0 HleuV]\^`d]_^]a`bcaae1 _his ^edfhnegfeihjkilimjmklo2 Gprofotnpruoqposrtnsv3 Ggln pvuwy~vxwvzy{z|}{{4 Gleuw~5 _lys 6 _gly7 _ile8 _val9 _glu : _leu; Bpro< Eleu= Egln > Epro? Emet@ _ser A _aspB GileC Gser D Gglu E _phe     F _ser        G _pro H _glyI _val" !#J _asp#"$&*#%$#'&()''+K Eval$+*,.1+-,+/0..2L Eval,21358243267559M Ephe 398:<C9;:9=<>?=@=A>B?B@ADN Eleu:DCEGKDFEDHGIJHHLO _ala ELKMOPLNMLQP _thrMQPRTWQSRQUVTTXQ _ala RXWY[\XZYX]R Hhis Y]\^`f]_^]a`bcadaebecdgS Hglu ^gfhjogihgkjlkmnllpT HvalhpoqsvprqptusswU Hser qwvxz|wyxw{z}V Hhis x}|~}~}W Hasp~X HleuY Hala Z Hpro[ Hgln \ Hphe ] Hleu^ Hglu _ _ala ` _glya _cys b Evalc Evald Ephe e Easpf _leug _ser h _gly  i _ala         j _phe  k _arg $ ! "#!!%l _val%$&(+%'&%)*((,m _asn&,+-/3,.-,0/12004n _asp-4357;4654879:88<o Hala 5<;=?@<>=<Ap Hthr=A@BDGACBAEFDDHq Hphe BHGIKRHJIHLKMNLOLPMQNQOPSr Htyr ISRTV^SUTSWVXYWZW[X\Y\Z[]\_s Hglu T_^`bg_a`_cbdcefddht Hlys `hgikphjihlkmlnmonqu Htyr iqprt|qsrqutvwuxuyvzwzxy{z}v _tyr r}|~}~}w _gly~x _phe y _thrz _his { _gln | _tyr } Hpro~ Hglu  Hleu Hleu Hglu  Hgln  _ala  Eala  Etyr  _gly   _leu          _ala   _glu   _trp  !#- "! $#%&$'$()%(&'*&+(,),*+/ _cys !./-02-036./10.4/5237 _gly0768:798; Hasn 8;:<>?;=<;@ Hlys <@?ACH@BA@DCEDFEGFI HleuAIHJLPIKJIMLNOMMQ Hlys JQPRTYQSRQUTVUWVXWZ _glu RZY[]bZ\[Z^]_^`a__c _ala [cbdfgcedch _asndhgikohjihlkmnllp Eleuipoqswprqptsuvttx Eileqxwy{xzyx|}{~{| Eala y _val _pro _gly Hcys  Htyr  Hpro Hthr Hala  Hala  Hgln  Hleu Hala  Hleu Hlys  Hpro Hleu Hile Hasp _ala      _asp       _leu  Bleu# !"  $ _asp$#%'+$&%$(')*((, _leu%,+-/3,.-,0/12004 _asn-4357;4654879:88< _gln 5<;=?D<>=<@?A@BCAAE _trp =EDFHREGFEIHJKILIMNJMKLOKPMQNQOPS _proFSXRTVYSUTSWVXRWZ EvalTZY[]`Z\[Z^_]]a Eile[a`bdhacbaefdgdei Easnbihjlpikjimlnommq Eala jqprtuqsrqv Ethrrvuwy|vxwvz{yy} Eser w}|~}~} _gly~ Gval Gser  Ggly Gala  _gly _arg  _lys  _ala  _ala  _ile _ser  _asn _ser  Gphe  Gcys  Gglu  _val _ser  _leu   Egln           Epro  _tyr % !"# #!"$#& _gly&%')&('* _val'*)+-0*,+*./--1 _phe +1024;1321546758596:7:89< _thr2<;=?B<>=<@A??C _his =CBDFLCEDCGFHIGJGKHKIJM _arg DMLNPWMONMQPRQSRTSUVTTX Hhis NXWY[aXZYX\[]^\_\`]`^_b Hgln Ybacejbdcbfegfhiggk Hprockpjlnqkmlkonpjor Hglu lrqsuzrtsrvuwvxyww{ Hiles{z|~{}|{~~ Hala | Hthr Hhis  Hleu _gly _ala  _asp _val Eile Ephe  Ethr Epro Ehis  Eleu _gly _asn _phe  _pro   _arg           _gly  Eile ! Eleu! "$(!#"!%$&'%%) Eglu ")(*,1)+*)-,.-/0..2 Ethr*21358243267559 Eile398:<@9;:9=><?<=A Ethr:A@BDGACBAEFDDH Ecys BHGIKMHJIHLKN Earg INMOQXNPONRQSRTSUTVWUUY BleuOYXZ\`Y[ZY]\^_]]a _lys Za`bdiacbaedfegfhgj _ser bjikmojlkjnmp _glykpoqsprqt _valqtsuwztvutxyww{ _thru{z|~{}|{~~ Hgln | Hala  Hgln  Hval Hala  Hgln  Hala  Hleu Hgln  Hgln  Hala  Htyr   _ala   _his   _lys   _pro  _leu Eval     Earg        Eleu  #! "$ _tyr $#%'/$&%$(')*(+(,)-*-+,.-0 _asp%0/13702104356448 _lys 1879;@8:98<;=<>=?>A _gly9A@BDACBE _valBEDFHKEGFEIJHHL _proFLQKMORLNMLPOQKPS _ala MSRTVWSUTSX GleuTXWY[_XZYX\[]^\\` Glys Y`_ach`ba`dcedfegfi Gasnaihjlpikjimlnommq _valjqprtwqsrquvttx _valrxwy{~xzyx|}{{ _glyy~ _leu _pro  _phe ! Ecys " Easp# Eile$ Egly% Ephe & Eala ' Eval( Egln ) _gly* _glu + Ehis , Eleu- Eile. Eile          / Eval        0 Eala       1 Ethr               2 Eglu       !            "3 _asp  " ! # % ) " $ # " & % ' ( & & *4 _asn # * ) + - 1 * , + * . - / 0 . . 25 _leu + 2 1 3 5 9 2 4 3 2 6 5 7 8 6 6 :6 Ileu 3 : 9 ; = A : < ; : > = ? @ > > B7 Ilys  ; B A C E J B D C B F E G F H G I H K8 Igly C K J L N K M L O9 Iala L O N P R S O Q P O T: Iala P T S U W X T V U T Y; Hala U Y X Z \ ] Y [ Z Y ^< Hgln  Z ^ ] _ a f ^ ` _ ^ b a c b d e c c g= Hala _ g f h j k g i h g l> Hval h l k m o r l n m l p q o o s? Hgln  m s r t v { s u t s w v x w y z x x |@ Hcys t | { }  | ~ } |  A Hala } B Hasn C Hile D Harg  E Hphe  F _gly G _tyr  H _ala I _glu  J _thr K _gln L _ser M _leu N _ile   O ?na P ?na Q ?mlt               R ?hoh S ?hoh T ?hoh U ?hoh V ?hoh W ?hoh X ?hoh Y ?hoh Z ?hoh [ ?hoh \ ?hoh ] ?hoh ^ ?hoh _ ?hoh ` ?hoh a ?hoh b ?hoh c ?hoh d ?hoh e ?hoh f ?hoh g ?hoh !h ?hoh "i ?hoh #j ?hoh $k ?hoh %l ?hoh &m ?hoh 'n ?hoh! (o ?hoh" )p ?hoh# *q ?hoh$ +r ?hoh% ,s ?hoh& -t ?hoh' .u ?hoh( /v ?hoh) 0w ?hoh* 1x ?hoh+ 2y ?hoh, 3z ?hoh- 4{ ?hoh. 5| ?hoh/ 6} ?hoh0 7~ ?hoh1 8 ?hoh2 9 ?hoh3 : ?hoh4 ; ?hoh5 < ?hoh6 = ?hoh7 > ?hoh8 ? ?hoh9 @ ?hoh: A ?hoh; B ?hoh< C ?hoh= D ?hoh> E ?hoh? F ?hoh@ G ?hohA H ?hohB I ?hohC J ?hohD K ?hohE L ?hohF M ?hohG N ?hohH O ?hohI P ?hohJ Q ?hohK R ?hohL S ?hohM T ?hohN U ?hohO V ?hohP W ?hohQ X ?hohR Y ?hohS Z ?hohT [ ?hohU \ ?hohV ] ?hohW ^ ?hohX _ ?hohY ` ?hohZ a ?hoh[ b ?hoh\ c ?hoh] d ?hoh^ e ?hoh_ f ?hoh` g ?hoha h ?hohb i ?hohc j ?hohd k ?hohe l ?hohf m ?hohg n ?hohh o ?hohi p ?hohj q ?hohk r ?hohl s ?hohm t ?hohn u ?hoho v ?hohp w ?hohq x ?hohr y ?hohs z ?hoht { ?hohu | ?hohv } ?hohw ~ ?hohx  ?hohy  ?hohz  ?hoh{  ?hoh|  ?hoh}  ?hoh~  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh   ?hoh   ?hoh   ?hoh   ?hoh   ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh   ?hoh ! ?hoh " ?hoh # ?hoh $ ?hoh % ?hoh & ?hoh ' ?hoh ( ?hoh ) ?hoh * ?hoh + ?hoh , ?hoh - ?hoh . ?hoh / ?hoh 0 ?hoh 1 ?hoh 2 ?hoh 3 ?hoh 4 ?hoh 5 ?hoh 6 ?hoh 7 ?hoh 8 ?hoh 9 ?hoh : ?hoh ; ?hoh < ?hoh = ?hoh > ?hoh ? ?hoh @ ?hoh A ?hoh B ?hoh C ?hoh D ?hoh E ?hoh F ?hoh G ?hoh H ?hoh I ?hoh J ?hoh K ?hoh L ?hoh M ?hoh N ?hoh O ?hoh P ?hoh Q ?hoh R ?hoh S ?hoh T ?hoh U ?hoh V ?hoh W ?hoh X ?hoh Y ?hoh Z ?hoh [ ?hoh \ ?hoh ] ?hoh ^ ?hoh _ ?hoh ` ?hoh a ?hoh b ?hoh c ?hoh d ?hoh e ?hoh f ?hoh g ?hoh !h ?hoh "i ?hoh #j ?hoh $k ?hoh %l ?hoh &m ?hoh 'n ?hoh! (o ?hoh" )p ?hoh# *q ?hoh$ +r ?hoh% ,s ?hoh& -t ?hoh' .u ?hoh( /v ?hoh) 0w ?hoh* 1x ?hoh+ 2y ?hoh, 3z ?hoh- 4{ ?hoh. 5| ?hoh/ 6} ?hoh0 7~ ?hoh1 8 ?hoh2 9 ?hoh3 : ?hoh4 ; ?hoh5 < ?hoh6 = ?hoh7 > ?hoh8 ? ?hoh9 @ ?hoh: A ?hoh; B ?hoh< C ?hoh= D ?hoh> E ?hoh? F ?hoh@ G ?hohA H ?hohB I ?hohC J ?hohD K ?hohE L ?hohF M ?hohG N ?hohH O ?hohI P ?hohJ Q ?hohK R ?hohL S ?hohM T ?hohN U ?hohO V ?hohP W ?hohQ X ?hohR Y ?hohS Z ?hohT [ ?hohU \ ?hohV ] ?hohW ^ ?hohX _ ?hohY ` ?hohZ a ?hoh[ b ?hoh\ c ?hoh] d ?hoh^ e ?hoh_ f ?hoh` g ?hoha h ?hohb i ?hohc j ?hohd k ?hohe l ?hohf m ?hohg n ?hohh o ?hohi p ?hohj q ?hohk r ?hohl s ?hohm t ?hohn u ?hoho v ?hohp w ?hohq x ?hohr y ?hohs z ?hoht { ?hohu | ?hohv } ?hohw ~ ?hohx  ?hohy  ?hohz  ?hoh{  ?hoh|  ?hoh}  ?hoh~  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh@NlC@1zG-1&n d@MnQ@1IlD,G{ca d@L ě@2c$,ٙc 2@MbM@3\(,-Vo d@M{lC@0\() ěcb @LL@1vȴ9X-n d@K9Xb@2Q-Fca d@K$S@2%,-Vc 2 @Kx@0lD,7Kƨo d @K&x@32nO0rnOcb d @L"nO@4Vu1`Acg  @LGz@4C%2sd d @K\I^5?@5r Ĝ2T9XbNce @J9XbN@2R+~"n d@J+@2q&x*(\)ca d@I/w@2E`A7L,# =pc 2@I\1&y@3>vȴ9X-zHo d@IdZ@3mO;dZ'-Vcb d@Jvt@3(\%(\cg d@J333333@4E#Z1cd1 d@JE@2tzG$C%cd2 @IHF@1 V,QRn d@H@0У =q-Rca d@Htj@1w+,U$/c 2@GQ@11hr )Vo d@Hr Ĝ@.Gz. 7KƧcb d@H@-Y0E`A7Lcg !2@IQ@. =q1"`Aod1 @H?|h@*hr!0XQnd2 @G$/@2L-7Kƨn d@G333333@3(\),z^5?|ca d @Fȴ9X@2p =-hr c 2!@Fp =q@37+0!$/o d"@GgzH@4\),ncb 2#@HbM@4-V+@og1 d$@F㕁$@5C+/wcg2 %@F vȴ@2XbM,5\(n d&@E\j~#@2t9XbN-Qca d'@Dfffff@3,=Ec 2(@E =p@41&)zGo d)@E @19XbM+Õ$cb d*@DStj~@17Kƨ,]-Vcg d+@D7lC@0x/eScd1 d,@D ě@/-V*Gzcd2 -@Dhr @4J=p . Ƨn d.@D#tj~@5o-V-Jnca d/@Cjvȴ@5E--Vc 20@C1o@4nP/Eo d1@DU$/@6Z1.šcb d2@E-V@7!$/.6ȴ9Xcg1 d3@C7Kƨ@7nO-Rcg2 d4@E^Q@8(1&x0Ecd1 5@C hr@4;dZ+|j~#n d6@BX\)@4x+Qca d7@A;dZ@5Vu+W =pc 28@BQ@6 =q)7KƧo d9@B2nO@3?|h)-Vcb d:@A}V@3Q)"`Bcg1 d;@B;dZ@2]-V)#Scg2 <@Ai+ @5V,9XbNn d=@A 1'@72 ě-*~"ca d>@Ah9Xb@8AGz.c 2?@AQGz@9w =p.glCo @ @AS@7˅Q0U\(n dA @B@n@8x1 ěTca dB @Aݑhr!@9;dZ1"`Bc 2C @B$/@:?|h2ZG{o dD @BQ@7 ě2+ Icb E @A<(\@9fx2LCn dF @@O;dZ@:Ao37+ca dG @@ěT@;$/2c 2H @@L1&y@6t@A}/w1&xce2 VdY @>["`B@Ab`A2nzGcz V2Z @=[dZ@A =p3NO;oh [ @A+ J@?5?|,"Mn d\ @BPbM@?NVu*$ca d] @B1&x@>0bM+޸Qc 2^ @CTtj@>?;dZ+|hso d_ @B@>1&y'-Vcb `@B`n@=-,~"n da@BZ1@<Vu.PbMca db@C#E@<|hs0PbMc 2c@Cfffff@< n0u\(o d@Bo@=n+1|hsn de@CE?|h@="2=/wca df@CF@>-1lCc 2g@Dfȴ9X@>E2tEo dh@Bٺ^5?}@?M3 O;dZcb i@CZ1@?Z1'0/n dj@Dzn@@m0-Vca dk@D~"@>G{//wc 2l@E&x@?)^5?}/]/wo dm@DH\)@@+ J.+cb dn@CҰ ě@AE/ cg do@DVu@Amp =0(\cd !2p@DC%@A9XbN1-Voe1 2q@C-V@A1O;doe2 r@DlC@=fffff-~"n ds@E.O;@<Q-$Z1ca dt@EdZ@<&-/tj~c 2u@F#@;l/qlo dv@DC%@;~"+ȴ9Xcb dw@D/w@;(ěScg dx@D;dZ@:F'-Vcd1 dy@E7KƧ@;1'& =pcd2 z@E-V@;ٙ0޸Qn d{@EwlC@;a$/2'lCca d|@F 7KƧ@ȴ9X2G{ca d@Gm@>y"`2,I^5?c 2@Gvȴ9@>|hr2tjo d@F(1&x@@tj2xcb 2@E/w@@E3Vog1 d@Ftj@@`A7L3scg2 @G ě@>kƧ0"`Bn d@G9Xb@>mV0Mca d@G1&x@=9XbN0 ěc 2@Hj~@=;dZ0$tjo d@Gc33333@>"-+ cb d@G5$/@@tj,GzHcg ad@F^5?|@@!Gz*(\cd1 Vd@G$/@@ěT-)xcd2 ed@F-V@@r Ĝ)ǮzHce1 ed@Gpn@A8tj,PbMce2 Vd@F =p@AQR*`Acz V2@F+@A =p)noh @GF@;Q0 7KƧn d@Gj~@: I^/j~ca d@H=/w@:nVu1Vȴ9Xc 2@HO;dZ@9?|h1^"o d@G_-V@9(\/U$/cb d@Gtj@8-hr!/tj~cg1 d@GdZ@9+ I,bMcg2 @G=p @: ě2tzGn d@H?-V@:/w3ca d@H I^@;tzG3;dZc 2@Il1&@:-V49+ o d@GϾvȴ9@;U$/4(\cb d@H,(\@;^Q61&xcg !2@HQo@:NzG67Kƨod1 @HTE@ڟvȴ2cb d@I\(@?vȴ9X3XbMcg d@IbM@@"`3,I^5?cd @Io@@lC1ne d@HE@Ag-1Qcz @HC%@A^5?|0vnh1 @H8r Ĝ@Atj2Rnh2 @I;dZ@"n d!@AǍO;d@2v25?|hca d!@A.vȴ9X@3(\2A7Kc 2!@A@@4׍O;d1rmo d!@AlC@1Q1 ncb 2!@An@2A7Kƨ/fffffog1 d!@BlC@0\(10 ěcg2 "@@Q@3D/2|(\n d"@?\(@3Ұ ě23Eca d"@? =p@29XbN1"`c 2"@?y"`@1`A71y+ o d"@?3@4aGz3xbMcb d"@??|h@5F3Qcg1 d"@?Ffffff@3^"4-cg2 #@=+ I@3 =p1:vȴn d#@nO@5`A79bMo d)(@=^Q@71&y7kC%cb d*(@Ix@21&y8xFca d/)@>š@2G{91&yc 20)@="`B@2lC:G{o d1)@=V@1 =p8$/cb 2*@@ ^5?|@2ȴ9X:1&n d3*@@N+@2Gz;rmca d4*@@$/@3<tc 25*@@@3+=zHo 6+@@=-V@5 =q;En d7+@@y"`@6dS<Sca d8+@A/vȴ9@6lC;zHc 29+@Ae@6tj:Qo d:+@?hr@7vȴ9;fffffcb d;+@>O;dZ@7E`A7L;I^5?cg d<+@= ě@87Kƨ;-Vcd d=+@<@A7K@8(1&x;ce >+@;_|hs@9*~";XbMnz ?,@AGz@7z^5?|<<1&n d@,@B:~"@7/w;/wca dA,@B)"`@8~":Qc 2B,@AlC@9~":;dZo dC,@B^5?|@8ao<߾vȴ9cb dD,@B;dZ@7nzG>Ecg dE,@CB\(@7Q?-cd1 dF,@Bj~#@5E=Vcd2 G-@Btj@8 ě9Qn dH-@BZ1@9l8-ca dI-@B =p@;Y9I^5?}c 2J-@BGzH@<=E8͑hr!o dK-@C9XbM@9-V7Qcb dL-@C3S@:ǮzH6{lCcg1 dM-@CXbM@9hr8CScg2 dN-@B^5?}@: =p5wO;dcd1 O.@CKƧ@;`A7L:_|hsn dP.@C@<$/;ȴ9Xca dQ.@BvE@=#$;C%c 2R.@Bhr Ĝ@>F-<`no dS.@Ctj@<;dZ;-Vcb 2T.@C I^@;lC<+og U/@A+@<3<vȴ9Xn dV/@AW+ I@<1&y<"ca dW/@@-V@=]p =;tjc 2X/@@lC@>Tj~<(9Xbo dY/@@O;dZ@;M=bMcb dZ/@A>5?|@:pbM>.O;cg !2[/@A/w@:(\?`A7Lod1 2\/@Avȴ@94E>0`A7od2 ]0@@ =q@8Cc 2`0@@S@?ɺ^5?}8o;dZo da0@@p@ٙ8ln df1@Btj~@?O;8u$/ca dg1@B1'@@" I^59Z1c 2h1@Cj~#@?r Ĝ9r ěo di1@BV$/@?x71&cb dj1@A/@?.+6-Vcg k1@A+@= I^55Qnd1 dl1@Ao;dZ@?Q5O\(cd2 dm1@A/;dZ@= I^54ؓtjce1 !n1@A  I^@?#S4ne2 !o2@BVE@@-:xn dp2@BE@@A7K;Ƨca dq2@Cf+ J@A =p;c =pc 2r2@CZ1@A#nP5?|@AH9Xb9G{o dz3@DR@Bhr 8o-Vcb d{3@D5?|@A^5?}7;Scg d|3@C\I^5?@AVȴ9X65?|cd !2}3@Bvȴ9X@AS$7$oe1 ~3@CP =q@A.+5mne2 4@Du$/@@z=p 9bMn d4@Dp =@?̋C9|hsca d4@E p =@?<(\;(\)c 24@EvE@>P`A7;W =po d4@D;dZ@>&x8-Vcb d4@D"@?7Kƨ7QRcg d4@D[dZ@=6lDcd1 d4@E|@?;dZ6^5?}cd2 5@D7Kƨ@?;dZ<)7KƧn d5@DnO@?O-V=1&yca d5@EGz@?Z1'=9Xbc 25@E+ @@/|hs= ěo d5@Dnvȴ9X@@O;d>=p cb d5@D@?Ƨ-@ I^5cg d5@DE@@NQ@yXbMcd d5@D=@@%$/A8Qce 5@C$/@?fffffAb ěnz 6@E;dZ@>@A7K>A7Kn d6@F =p@>+C%>nca d6@GGz@=^5?|=Õ$c 26@G(\@=ڟvȴ=Qo 7@FE@=bM<7KƧn d7@G%?|h@=͑hr!;Ovca d7@GA7K@;dZ9vcg2 d7@G ě@@;dZ:Z1'cd1 8@F` ě@<@@Vfffff@/$/5kQn d>@?V@/ 7KƧ4cnPca d>@@I^5?@,C3h1&xc 2>@@klC@*KƧ3Eo d>@>|j~#@-Q50bMcb d>@?E@,zH6TEcg d>@@*vȴ@.0 =q6\(cd ?@@x@-dZ12hrn d?@@IlD@+$/1G{ca d?@?g-@*I^5?0Lc 2?@>tj@,&x/bMo d?@@C%@,ȴ9X0-cb d?@AE@+5?|h-G{cg ?@A$/@,h\),GzHsd d?@A``A7@.ȴ9X)"`ce @@?J=p @'A7K0;"`Bn d@@>WKƧ@&S.A7Kca d@@?(\@%`A7,$/c 2@@?t@%`A7*.O;o d@@=ES@$lC0 ^5?}cb 2@@=n@#+ 0zHog A@?E@"^5?|-W =pn dA@@W+@!z^5?|+~"ca dA@A I^5?@"Gz+1&xc 2A@A]@"nO-Z1o dA@@UQ@ ě,4j~cb dA@@1&y@ěT* ěcg !2A@A(F@cS(Mod1 2A@@+ @$/+ =pod2 B@AK I^@#b`A),Cn dB@A"`B@$ڟvȴ(Eca dB@BQ@#*~")Z1c 2B@Ctj@$DS)hro dB@B/@&+ J&"Mcb dB@B.+@#Z1$O;dcg1 dB@AgzH@'Q%Vtcg2 dB@B?|h@$nP"O\(cd1 C@Bql@ $/)Ƨ-n dC@C ě@H9Xb*Xtjca dC@C9XbM@-A$/c 2C@C?|h@A7Kƨ-XbMo dC@BI^5?@{lC)?|hcb 2C@B@@Q+Vtog D@Bj~#@ "`A.Mn dD@B~"@ zG0lDca dD@C ě@#(\0nPc 2D@Cl@#b`A1Eo dD@BZG{@!Gz1lDcb dD@B|1&y@"`A73\(cg dD@AdZ@#b`A37Kƨcd !2D@AM/w@#1'31hr oe1 2D@AlC@$LI^5?4C%oe2 E@C$/@$R/Jnn dE@CdZ@&G{/=Eca dE@D{lC@'5?|,^5?|c 2E@D\(@(nO-$o dE@C@)zG{/GzHcb dE@Cvȴ9@)+ I0Scg adE@BrnO@).zG0tjcd1 VdE@Cj^5?|@*V2tcd2 edE@Bvȴ9@)vȴ9X2 Vce1 ed E@C dZ@* =q3@ce2 Vd E@B]O;dZ@*`ěT3>5?|cz V F@Dnvȴ9X@%NVu+n d F@D$/@%_;dZ(vca d F@ES@$zG( I^c 2F@FO;@% I^5?'O;o dF@D5?|@$NVu&%`A7Lcb 2F@D=p =@!\(&lCog G@E+@!*\1&n dG@FS =p@ =p*9"`ca dG@F߾vȴ9@"p =q+:^5?|c 2G@FQ@#"-Mo dG@FE?|h@N+,(\cb dG@EI^5?@zG,8Fcg dG@E2`A@ :^5?|, 7KƧcd H@Go;dZ@"R)hr n dH@HěT@$S*C%ca dH@G+ I@')lD*1&xc 2H@Hovȴ9@(zG+I7KƧo I@Gix@(!Gz)j~"n dI@GLC@+( ěca dI@G^5?|@+fffff&;lCc 2I@GmO;dZ@*ٙ$ A7Ko d I@F"`B@+1&y)zGcb d!I@Ffȴ9X@.fffff(CnPcg1 d"I@FFx@++Q+ؓtjcg2 #J@H5?|@-&QRn d$J@H[Q@.KƧ#&xca d%J@GS@0S"{dZc 2&J@GQ@01&xCo d'J@IS@0E$ncb d(J@Iz=p @.5\(&+ Icg !2)J@I@,nO$nod1 2*J@IlC@. ě(C$od2 +K@Gtj@1[dZ$+n d,K@G2-V@2$/"vȴ9Xca d-K@F$/@2n$@c 2.K@FnQ@2]/w& ěo d/K@GR@3KƧ#Ecb d0K@G%Q@5E"O;cg1 d1K@HDZ1@3Ձ$/"WO;dcg2 2L@EzG@21'"zGn d3L@EM-V@2 I^#}Eca d4L@EnO@4J~""xFc 25L@E!l@4\( I^5?o d6L@D I^5@1ڟvȴ"ffffffcb d7L@D1&x@29XbN#vȴ9Xcg1 d8L@E j~#@0u$/#)xcg2 9M@Dr Ĝ@5&-$Rmn d:M@D|C@6d/#ěTca d;M@C\(@6+ I^#"`c 2<M@C7Kƨ@5hr &-hr!o d=M@D+ I@7j~%^5?|cb d>M@Ej^5?|@8  I^$+cg ad?M@E@7`A7&Qcd1 Vd@M@E+@8G{"zGcd2 edAM@FQ@8|hs& Ƨce1 edBM@F1R@9NO;"vȴce2 VdCM@FQ@8hr #cz VDN@C_vȴ9@6U?|h!hr n dEN@BQ@6>vȴ9X"bMca dFN@B[ I^@7^5?}"=Ec 2GN@BE\(@8R-V 5\(o dHN@BVfffff@5ql|hrcb dIN@B1&x@3ȴ9Xcg dJN@B;Q@3j=p |hrcd1 dKN@BO|hs@3!$/!cd2 LO@B1&x@8E$vn dMO@A߾vȴ9@9^Q%B\(ca dNO@A;dZ@9lC%7KƧc 2OO@@&x@9Xtj'A7Ko dPO@B'lC@9E'hr cb QP@@@8$/#Z1'n dRP@@'-@8v#PbMca dSP@?$/@8 ě hr c 2TP@@^5?|@9EEo dUP@@0ěT@6}E#I^5?}cb 2VP@@ =q@6  I^!,1&yog1 dWP@@u$/@5;dZ% ěcg2 XQ@>ES@8jn dZn dYQ@=lD@8G{33333ca dZQ@=F@7SkQc 2[Q@> C%@6nPI^5?o d\Q@<j~#@9>""`Acb ]R@=(1&x@8bM\(n d^R@=ql@7NO; xFca d_R@<"@5KƧ ȴ9Xbc 2`R@=lC@4j~# Eo daR@< I^5@7(\hr Ĝcb dbR@;dtj@8$tjnPcg cR@:ěT@9+C%+nd1 ddR@:ix@7glCncd2 deR@9qR@9zGQce1 !fR@96+ J@7-VQne2 !gS@;@5 7KƧn dhS@;7KƧ@4:vȴ7KƧca diS@<+ J@3O;dZQc 2jS@<\hr@2-O;dZ+o dkS@9E@4?;dZ =pcb dlS@8O;@4j~"\(cg dmS@7Vt@3x7KƧcd !2nS@7$Z1@3ڟvȴ6Eoe1 2oS@6v+ J@3 Qoe2 pT@A7K@2(\Z1c 2sT@?9"`@11' ěo dtT@=tE@3ȴ9Xb!O;dcb duT@>KƧ@3=/w"Ecg1 dvT@<bM@37Kƨ"{dZcg2 wU@?Vt@37KƧhr n dxU@@M-V@3`A7\(ca dyU@@I+ @2 =p-Vc 2zU@@+ @29XbM GzHo d{U@@F@51REcb 2|U@@p =@5hrY+ og }V@?m@27Kƨ zGn d~V@?333333@2Z1"`Bca dV@?I7KƧ@0lCXbMc 2V@?9Xb@/nzGQo dV@=ѩl@2P =q=p =cb dV@=j~"@1lI^5?;dZcg V@=-V@1?1&xnd1 dV@lC@08F XbMn dW@>M@-ěSnPca dW@?|hs@,p =cSc 2W@@Bm@*zG5?|ho dW@=fffff@-/;dZcb dW@=`ěT@* =pncg !2W@=I^5?}@(ۥSRod1 2W@=Rm@*$/`A7od2 X@@L(\@.Ƨ-nOn dX@@ =p@.+ JO;dca dX@AV@.vȴ9~"c 2X@A~"@,g-qlo dX@@Ƨ@/(\tjcb dX@@u\(@/\(!tjcg dX@@@07Kƨ#šcd1 dX@@LI^5?@,"`"ncd2 Y@AQ@0  I^O;n dY@BL(\@08FQca dY@Bj~#@- =q $/c 2Y@C#S@-Dtj -Vo dY@BS@1u\( /wcb Z@B~"@,+ JEn dZ@BQGz@*1l^5?|ca dZ@Bo@(7Kƨc 2Z@C =p@&=p Qo dZ@A"`B@)GzHȴ9Xbcb dZ@AB\(@+tncg dZ@Ab\(@- ěT I^5?cd [@B4E@'"`BlCn d[@Bg-@%33333hr!ca d[@Ct@&B\(bMc 2[@C}@$d/fffffo d[@A9XbN@%nOW =pcb d[@A4j~@%;dZsEcg d[@@p =@$Rhrcd !2[@@ȴ9X@"-V)lDoe1 [@@7-@&8QcSne2 \@C89Xb@(ɺ^5?}"`Bn d\@Cl@)$/ I^5ca d\@Dr`A@)'lC5?|c 2\@E`A7@(^5?|@no d\@C =p@,ZvȴQcb d\@C@, KƧcg ad\@CC%@+V+ J#LI^5?cd1 Vd\@BO;d@-\(!&fffffcd2 ed\@CwlC@+s33333%Õ$ce1 ed\@B|hs@-KƧ#Cce2 Vd\@BF@,%"cz V]@DO\(@)G{ȴ9Xbn d]@Dщ7Kƨ@)nzG tjca d]@EGz@&~"Ƨ-c 2]@E+@%m^5?|o d]@D`A7@*C%O;dcb d]@Dpn@-`A7dZ1cg d]@C@.C$ݿ\(cd1 d]@EF@/bMZ1'cd2 ^@Dv@$QRn d^@Dj~@! =pzGca d^@D1&@ nP$/c 2^@EW =p@tjno d^@CKƧ@ bM I^5?cb d^@C5?|@ I^5?} I^5cg d^@CM@lC^5?|cd !2^@B1'@Mj~#oe1 2^@BbM@M\(oe2 _@D\(@"5?|# =pn d_@EQl@!TE5?|ca d_@FzH@"^5?|1&c 2_@Fmhr!@!5?|GzHo d_@DE@"O\(r Ĝcb `@F4S@#EA7Kƨn d`@FGz@$nOca d`@GS@';dZ?|hc 2`@G^5?}@(qlȴ9Xbo a@Fv@)aGzn da@F-@+nffffffca da@F@-nɺ^5?}c 2a@FG-@-_;dZxo da@F+ I@,|hrEcb a@E?|h@)|hs!nOsg b@F\)@/QxFn db@FG{@1+ I^hrca db@F^O;@2nOZ1'c 2b@Fdtj@2mhr!vȴo db@Gfffff@1߾vȴ9nO;cb db@G1&x@3.VuO;dZcg1 db@HC%@0n-Vcg2 c@Ehr@2^Qtj~n dc@E?;dZ@3`A7LbMca dc@E81&x@4w+7Kƨc 2c@EUQ@4p = Qo dc@D =q@2B I^5xcb dc@CG{@2bM\(cg1 dc@Dl@07KƧ+ Icg2 d@EO;d@5dZ1u\(n dd@ES@6+0 ěca dd@DM@7#nPvȴ9c 2d@D!$/@7CnP`A7Ko dd@E$@7fffffkQcb dd@F;Q@7ixbMcg add@F7Kƨ@8C$bMcd1 Vdd@FE@6W =pffffffcd2 edd@G;C%@8l333333ce1 edd@GD/@6"\((\)ce2 Vdd@GlD@7o1&xcz Ve@C;dZ@7(r Ĝ\(n de@C*^5?|@7XtjcSca de@C$/@8XbM1&xc 2e@C&ȴ9X@9A7K dZ1o de@BnO@6S ěTcb de@BKƧ@6š /wcg !2e@AěT@7 VnOod1 2e@A =p@6\(1&xod2 f@Bfffff@9bMvȴ9Xn df@BS@:33333lCca df@AS@;VuZ1c 2f@A =q@<9XbMƧo df@Bvȴ9X@;p =q I^5?cb df@C?\(@;QlCcg df@C^5?}@:l ěTcd1 df@C3E@<̋C!~vȴ9Xcd2 g@Au\(@9$/-Vn dg@@dZ@:j~Vca dg@@t@:j~"nO;c 2g@Ab\(@:xF9XbNo dg@@^+@8nO7Kƨcb 2g@@ilD@7$/ \(og h@@B I^5@:VO;dn dh@@=V@:I^5?Z1'ca dh@@:n@9S?7KƧc 2 h@@;Q@9?hr!o  i@@;Q@8y"`vȴ9Xn d i@@+@7,I^5??ɺ^5?|ca d i@@"`B@6+?-Vc 2 i@@N"@5G{@-o di@?|hs@6 + Icb j@A-V@7&x?Z1'n dj@AbM@6@Mca dj@BA7K@7p =@ 1&xc 2j@BM@7V@o dj@B--V@5^5?|?~"cb dj@AO;dZ@4wKƧ?Qcg adj@A5?|@4n+QRcd1 Vdj@AlC@3U$/@C$cd2 edj@AMO;dZ@3H9XbSce1 edj@AxF@2-V?^5?|ce2 Vdj@A:G{@2'-?ʟvȴ9cz Vk@Ax@9hr @nn dk@B + @:RnO@ =pca dk@Btj@:{lC@Gzc 2k@Bx\)@;@2-Vo dk@A33333@;1&y@tj~cb dk@AdZ@;KƧ?+cg d k@Aj~#@=!7Kƨ?tj~cd !k@Atj@=/;dZzGne d"k@AƧ@=&x I^5?cz #k@@@>Z1+nh1 $k@A!hr @=dZ1&ynh2 %l@A|1&y@9KƧ@\(\n d&l@A]O;dZ@: ěT@1&ca d'l@A97KƧ@8vȴ9@&xc 2(l@@R@8$@bMo d)l@@`A@;@Y+ cb d*l@@C@;,C@!tjcg1 d+l@@l@<}-V@Qcg2 ,m@A\(@8ql@!aon d-m@Aȴ9X@7A$/@#ca d.m@@vȴ9X@7f-@%c 2/m@Aȴ9X@7tj~@'cSo d0m@B--V@77Kƨ@$Scb d1m@B:~"@5t@%^5?|cg !22m@AE@4&x@%33333od1 3m@Bm@5;dZ@&xnd2 4n@@RM@74zG@$ I^5n d5n@?nVu@7U\(@%+ ca d6n@>2 ě@6 ě@$!oc 27n@=lC@7.+@!o d8n@?-@8O;dZ@&Qhr cb d9n@> lD@8E@(KC%cg !2:n@>L@8O;@* ěod1 2;n@<+ I@9TzG@'p ěod2 <o@=^Q@6A7K@%{dZn d=o@<0 ě@5eQ@$;dZca d>o@;+ I@6]p =@#&xc 2?o@:o-V@6[dZ@!z^5?|o d@o@;\(@4/;dZ@%-cb Ap@:&x@72nO@%vn dBp@9zH@8XbM@%nzGca dCp@9O;d@9G{@#.O;c 2Dp@8vȴ9@9h1&x@!Eo dEp@9%`A7L@8Ƨ@( ěTcb 2Fp@8z1'@7׍O;d@)og1 dGp@87O;d@:$@'1&ycg2 Hq@:t@9Q@"Qn dIq@;r-V@:c =p@ ȴ9Xca dJq@:ěT@9lC@2-Vc 2Kq@:IlD@:ěT@nOo dLq@>"@=|hr@Y+ ce1 edQq@>h1&x@;-@dZce2 VdRq@>?|h@<-@u\(cz VSr@;o@8Ƨ@I^5?}n dTr@:|j~#@733333@Vtca dUr@8t@7"`B@ I^5?c 2Vr@8\(\@8E@Ro dWr@;=-V@6/@/wcb dXr@<+@6O;d@G{cg adYr@=\(@7+@tjcd1 VdZr@=7Kƨ@6Q@Ecd2 ed[r@>f-@8E@ \(ce1 ed\r@> ě@6O;d@bMce2 Vd]r@?U\(@7zG@\(cz V2^r@@R`A@8-V@$/oh _s@8TE@7-@1&xn d`s@6(\@7o\(@nca das@61&x@8͑hr!@G{c 2bs@5B`A@8zG@vȴ9Xo dcs@6glC@6~"@ tjcb dds@7`@5"`@!'lCcg des@6E@4WKƧ@!zG{cd !2fs@5zH@4-V@ PbMoe1 2gs@7XbM@3w =p@" =poe2 ht@6R@9@`A7Ln dit@6)^5?}@;+Ƨ@^5?|ca djt@6cnP@;"`B@Jnc 2kt@5mV@Q@#+ I^ce pt@5Q@?ؓtj@$-Vnz qu@7+ I@;R@O;dn dru@8A7K@<1&y@1&xca dsu@8!7Kƨ@<$/@`A7Kc 2tu@85$/@&x@p =cg adwu@8j~@?ݲ-V@hr cd1 Vdxu@9Tj~@>;dZ@tjcd2 edyu@8`A7K@@f-@Sce1 edzu@9"@?(\)@ O;dce2 Vd{u@8@@8F@Ccz V2|u@8u\(@@7Kƨ@!s33333oh }v@8,@:7Kƨ@`A7n d~v@8Y@9tj?5?|hca dv@7=p =@8zG?XbMc 2v@7E@8\(\?lCo dv@9n@9XbM?hr cb dv@:ܬ1&@:VE?Scg adv@;Y"`@:-?ļj~#cd1 Vdv@;m@;@ I^5cd2 edv@<`@;qlEce1 edv@eS@2+ I@xcg z@?W+@1S@Ƨnd1 dz@>|hs@3Ձ$/@ffffffcd2 dz@@+Q@24j~@Qce1 !z@@ ~"@3`ěT@ -Vne2 !{@O;d@+t@ffffffc 2{@>"@);dZ@lo d{@<\(@*ěS@ 333333cb d{@;.zG@+$Z1@Scg d{@:EQ@*'-@cd !2{@:7KƧ@(1'@W =poe1 {@92 ě@+A7K@;dZne2 |@?`A@-$/@zGn d|@@y+ @,hr!@;dZca d|@@ΗO;@.E@+ Jc 2|@A@n@0F@p =qo d|@@dZ@-vȴ9@ -cb d|@@}-V@+G{@zGcg ad|@@1'@)+ I@ffffffcd1 Vd|@@ ě@-E?$/cd2 ed|@@=@'|hs?1&yce1 ed|@?GlC@+zG?tj~ce2 Vd|@?@),1&y?ffffffcz V2|@>ǮzH@'vȴ9X =poh }@@lC@.#S@-Vn d}@@x@/-V@!1&ca d}@A^5?}@/\(@!Qhr c 2}@A^5?}@0lC@"O;do d}@@\(@.Jn@#Ecb d}@@GO;d@+j~@"1&cg d}@@`A7L@,C$@|hrcd ~@A$/@-9XbM@ fffffn d~@B\(@,ۥS@ j~#ca d~@C n@.ȴ9X@|hrc 2~@C&x@/\)@?|ho d~@Bؓtj@) I^@ hr cb d~@B7+@( Ƨ@ 8Qcg d~@AŁ$/@(;dZ@GzHcd !2~@A&x@'/w@?|hoe1 2~@B\)@(xQ@;dZoe2 @BR@.`A7L@&xn d@CS@0Z1'@p =qca d@BdZ@1t@Qc 2@CuS@2+ J@5?|ho d@BE@0+@/vcb d@Btj@-\(\@ $/cg d@Bh9Xb@,S?^5?|cd1 d@C@,G{@+ Icd2 @BnQ@27 =p@ɺ^5?}n d@BX\)@3-V@ca d@B I^@3x@5?|c 2@C1$/@5S@mo d@Ahr!@3Vu@"`cb d@AR@3ϝ-V@W =pcg d@@n"@3v@Vcd1 d@A#tj~@5@bMcd2 @C+@2$/@ hrn d@Cp =@3 lD@"׍O;dca d@DT9XbN@3|hs@!Sc 2@D^5?|@3?|h@" A7Ko d@Cj~#@1ۥS@$ؓtjcb d@DKQ@17Kƨ@&A7Kcg d@DR-V@2lC@(^5?|cd !2@CƧ@3j~@*moe1 2@Dp =@3|hs@)nPoe2 @D^vȴ9X@2b`A@9XbMn d@Dp =@2O;dZ@$/ca d@EQ@3~5?|@.zGc 2@E\(@3I^5?@2-Vo d@EQ@0$/@'-cb d@E6-@/7Kƨ@A7Kcg d@D ě@,+ I@`A7Lcd !2@Dp =@,LI^5?@+ Joe1 @DQ@+7Kƨ@lDne2 @Dtj@4 =p @tjn d@D/@5Q@lCca d@EnO@6O\(@c 2@DQ@6~"@KƧo d@C33333@5tj~@+cb @E~Vu@6o@(\)n d@EA7K@8 ~"@xca d@Ec =p@91&x@ + Ic 2@E.O;@9#nP@&xo d@F&x@8"`B@ cb @EFx@:=p =@e`A7Ln d@Dr Ĝ@;h\)@Qca d@Ef$/@<;lC@$/c 2@EV@<ǮzH@ QRo d@D~"@<7O;d@A7Kcb d@D"\(@=RnO@-Vcg ad@Co@=-V@ I^5?cd1 Vd@DAR@> I^5@cd2 ed@C#tj~@>Q@ ce1 ed@C+@?zG@P`A7ce2 Vd@CHtj@?l1&y@tj~cz V2@BR@@?;dZ@ \(oh @ENzG@YXbM?睲-Vc 2 @E-V@>vȴ9Xם-Vo  @E(\@?;dZ?Qn d @ElD@@=O;dZ?tjca d @FdZ@@Qhr ?+ Jc 2 @Gr Ĝ@@KC%@Qo d@EO;dZ@@ =p@~"cb d@EQ@AZn@+cg d@ESS@AE?7KƧcd1 d@ElC@A+ I@Z1cd2 @G-@@klC?`A7Ln d@G7KƧ@@;Q?^5?|ca d@H; I^@@~"?nc 2@H/@@LC? =po d@G@@J~"ѿ/wcb @H A7K@A@ =q?mn d@Hm@A+@?|hsca d@H+ @Aq$/@1&c 2@Io@Ahr!@]/wo d@Hft@BeS@A7Kƨcb d@HG{@Bvȴ?ncg d@H-@BoVtcd !2@G ě@B:n+ Joe1 2@HdzG@Bvȴ9 ěToe2  @H=p @A\(@["`Bn d!@H =p @@lC@1&xca d"@HzH@@*1'@P`A7c 2#@HzG@?-V@"`o d$@Gd/@A6fffff@]/wcb d%@Gm-V@At@F-cg !d&@GbM@Bahr @fffffcd1 d'@GlC@B`ěT@+ Jcd2 a(@GC33333@CF@-Vne1 d)@G+ @C I^5?@tjce2 d*@HLhr@B@@ e`A7Lce3 ed+@H 1'@C+@cz2 ed,@HzG@BF@!;dZcz3 Vd-@H|hr@CtS@ + Ich2 V.@H@?~Q@5?|hn d/@HP ě@>nO@;dZcaad0@Hp =@> hr!@bMcabd1@HS@=/@Sc !22@IS@>NO;@;dZo d3@HBm@=a$/@+ Jcbad4@G"`B@=PbM@vȴcbb5@G{ I^@=_|hs@ Qsga6@HwO;d@=U$/@osgb7@HQ@<$/@+n d8@I1&y@<8Q@\(ca d9@IQ@:\(@>vȴ9Xc 2:@IƧ@:@y"`o ;@I$/@9dZ@@nn d<@IƧ@8Q@"ca d=@ItS@7nP@`A7Kc 2>@Iv@6b\(@nPo d?@Jx@8*~"@TEcb @@Hv@7XbM@$/n dA@HL(\@7 7KƧ@'-ca dB@H9XbM@7S@+c 2C@Ghr!@6%@zG{o dD@Gtj@7vȴ9X@tjcb dE@GdZ@6i^5?}@Qcg dF@FxbM@6x@ A7Kƨcd dG@E\)@5-@ lCce H@ED9XbN@6CnP@ XbMnz I@HrM@87KƧ@=p n dJ@Hmp =@8WKƧ@ ffffffca dK@IS@7^5?}@mc 2L@H^5?|@6-V?oo dM@H^Vu@9zG@vȴ9cb dN@H0n@9zG?C$cg dO@Gqo@:5\(?lCcd1 dP@Hhr @;zG? =p cd2 Q@IS@8m@-n dR@JB\(@77KƧ@Vuca dS@J?|hs@6nP@c 2T@J ě@5q&x??|hso dU@Jn@8$/@I^5?}cb dV@K "`B@9tj~@bMcg dW@Kx@9\(@ Mcd dX@Khr @;\j~#@ Qce Y@LV-@;`A@zGnz Z@IG{@5_vȴ9@Sn d[@IC@3C%@ I^5ca d\@Itj~@3a$/@dZ1c 2]@HO;d@2333333@ no d^@J)+ @3XQ@&xcb d_@Iϝ-V@3["`B@+ Jcg d`@JI+ @30`A7@W =pcd !2a@JlC@3^vȴ9X@ ěoe1 2b@JKƧ@2 =p@ǮzHoe2 c@H9XbN@48bM@&xn dd@Gӕ$@3+@ I^5ca de@G I^@3 O;dZ?Mc 2f@HlC@3z1'?° ěo dg@GR I^5@4"`B@&xcb h@GMO;dZ@2 O;dZ?xFn di@GS@1\(QRca dj@Fdtj@2 =pc 2k@F7 =p@1^5?}7KƧo dl@GV@0xěScb dm@G@.E?$/cg !2n@HTj~@0 ^5?}+ Jod1 o@Gtj@,ɺ^5?}?I^5?}nd2 p@Fo@2zG?-Vn dq@E_-V@3aozG{ca dr@Envȴ9X@4+ ?nc 2s@Ehr!@5 n?XbMo dt@D@2bM?"`cb du@D\(@3eS?$/cg dv@CnP@333333bMcd1 dw@Chr!@2 =p?bMcd2 x@Eao@5Gz~"n dy@Edj~@74zG+ I^ca dz@Dm@7fffff-Vc 2{@DtS@7+o d|@E-@75?|푿-cb d}@FQ@7E`A7L`A7Lcg1 d~@Etj@9mO;dZtj~cg2 d@F/@5\)\(cd1 @D]hr!@8h\)?C$n d@Cp =@9" I^5Qca d@Cvȴ9@:-Vp =qc 2@D.O;@;E`A7L?XbMo d@CK I^@9\(??|hscb @C^5?|@;odZ1n d@D @<`A7Kǿ$/ca d@C}@=Q&xSc 2@B+ @= CC$o d@D"-V@< I^5 ěTcb d@Di"`@=^5?}O;dZcg1 d@D1&x@;eS_;dZcg2 @CG{@>e`A7L;dZn d@C&fffff@?P =qbMca d@B$/@?zGVtc 2@B+ @?\(hr o d@Cvȴ9@@6fffff?O;dZcb d@D:vȴ@?nO? ěcg d@DY+ @>Fncd @B+@@5Q녿j~"n d@Ahr!@@-V$/ca d@B@A6ȴ9X\(c 2@B{lC@Ao\(+o @Aj~#@Aj~ |hrn d@BZ1@B"M\(ca d@A =p@BF1&c 2@BnQ@CěTno d@Avȴ9@BNzG-Vcb @@-@BNVu\)sg @A[ I^@BxQn d@AI@CdS1&yca d@A^5?|@CGO;d"`Bc 2@A+ @C;dZ?ܛSo d@@O;dZ@CnP+ Jcb d@@+ I@C9XbMcg ad@@Q@Dovȴ9O;dcd1 Vd@?,@CZG{;dZcd2 ed@?Fx@DE + Jce1 ed@>?|hs@C1&x `A7ce2 Vd@>O\(@D@`A7 C%cz V2@=^5?|@DxbM/oh @A$/@B^5?}?\(n d@B`A7L@BlC?ȴ9Xbca d@B =p@Btj? =pc 2@CzH@BS@Vto d@A9XbN@A+ ? I^5cb d@A7-@AlC?+ Icg d@A2nO@BO;d?ncd @C @BlC?Vun d@C?|h@B1&y?-Vca d@C5?|@Cc =p?ە$/c 2@DmE@C =q?tj~o d@C(\@Bt9XbNZ1'cb 2@C\(@A-V^5?|og1 d@D+ J@BE˿j~"cg2 @CnP@CoXbMn d@CޗO;@DE+ Ica d@CF@DXbM?\(c 2@DO;dZ@E&$/@r ěo d@C{"`B@E p =$/cb @C(9Xb@DQ?/vn d@BI^5?@DC@ O;dZca d@CnVu@Dfffff@kQc 2@CQ@DI^5?@hr!o d@BBm@De`A7L@ ~"cb @C\)@CzG@Vun d@D bM@CnO@vȴca d@DӶE@CzH@tj~c 2@E+lC@C-V@Qo d@D A7K@B\(@/vcb d@CrnO@B-@ɺ^5?}cg d@Ci7KƧ@A֧-@Ecd !2@CR@As =p@O;doe1 @Ctj~@AbM@vȴ9Xne2 @E G{@D G{@Mn d@E@D_|hs@ Ƨ-ca d@E`A7@Ev@xFc 2@F2 I^5@EBm@/wo d@E =p@Dft@xcb d@F (\@CKƧ?$/cg d@F'zH@C\)?5?|hcd1 d@FS@Cc$@;dZcd2 @E#nP@EmO;dZ@Fn d@E\(@F =p@`Aca d@E Q@F-@šc 2@Ec =p@Fg-@Qo d@Dvȴ9X@Fw+@xFcb @DR@EnO@\(n d@Dqo@E9XbN@ dZca d@Dm@E&x@"1&xc 2@E`A7@EX9Xb@$o d@C =p@E]O;dZ@!O;dcb d@C4tj@E-@ 49XbNcg d@Bv@E =p@ 0 ěcd1 d@C?v@F?|h@"tjcd2 @E A7K@D =p@!\(n d@E}V@D\(@#:G{ca d@FZ1@DbM@$|hsc 2@FC%@DTtj@'-hr!o d@E =q@CpA7K@!p =cb d@F'KƧ@BnO@#mhr!cg d@F6$/@B?-V@"\(cd d@Fx@A =q@#zGce @Fl1&y@A\(@&^5?|nz @FC%@D9Xb@#]-Vn d@G1'@EěT@$;dZca d@FE@Em@'Rc 2@G@A7K@E@)$Z1o d@GS@EX\)@"9XbNcb d@G\(@Er-V@ cScg d@F"`B@DC%@ xQcd @FVE@E^5?|@&`An d@FG{@F_\(@(^5?}ca d@E1&y@F 7KƧ@*j~#c 2@E7Kƨ@F9@-A7Kƨo d@E1&y@F I^@'6Ecb d@E"@G+lC@$ =pcg d@E` ě@Gx@#U$/cd1 d@FěT@G@$և+ Jcd2 @E^vȴ9X@E~"@*\(n d@EnP@E*~"@,`A7Lca d@E"@DC%@.5\(c 2@E/w@D?|h@0[lCo d@D7KƧ@DO;@+`A7cb d@C I^5@ES@*h\)cg1 d@DJ1'@D/;dZ@-XbMcg2 d@Cql@D?|h@(xcd1 @Fvȴ@DR@,šn d@F`A7@Dvȴ9@.*~"ca d@G@D I^5@/hr!c 2@GU?|h@DXtj@0o d@GlC@C;dZ@,6Ecb d@F@C\)@+"`Bcg !2@Ffffff@BC%@+ěTod1 2@FzG@BI^5?@)j~"od2 @GE@E5Q@/@nn d@Gw-@E+@0r-Vca d @F;dZ@F lC@1pbMc 2 @G5S@F^5?}@2-Vo d @G"`B@F.Q@/0 ěcb  @F` ě@EzG@19XbNn d @EQ@FE@2O;dZca d@Eə@FԼj~@2LI^5?c 2@EbM@G9@3;So d@F&t@E+ J@4ěTcb d@E`A7@F"-V@5ȴ9Xcg !2@Efffff@EbM@4Vuod1 2@E?|h@Fl@6 ěTod2 @EF@G @1 nn d@Ev@G =q@0 =pca d@D-@HGz@0KƧc 2@D@H1&@0Gzo d@FzG@GěT@/tjcb d@FՁ$/@GǮzH@/tjcg d@G'O;d@H+@,y"`cd1 d@G*=p @HzG@0tjcd2 @D\(@G"`B@0r Ĝn d@C1'@GO;d@0P ěca d@Cb\(@Gvȴ9X@1zGc 2@Ctj@G'O;d@2\1&o d @C~5?|@GJ1'@.ffffffcb d!@CnO@GP =q@+dZcg d"@C$/@F+ I@)Scd1 d#@DM@H@*/cd2 $@B`A@H @1Z1n d%@BcnP@G`A@2Ұ ěca d&@AԼj~@G-@29XbMc 2'@Adtj@G\)@1$o d(@B"\(@HE@3Vȴ9Xcb d)@AI^5?@Hj~#@4PbMcg !2*@A^Q@G/w@4tjod1 2+@ABnO@I7Kƨ@4$od2 ,@A\)@Fn@2nn d-@Ab ě@Flj~#@1ڟvȴca d.@@;dZ@Fo-V@2stj~c 2/@@>zG@Ffffff@1Fo d0@Aj~#@Ej~@1+cb d1@BQo@ElD@0ȴ9Xcg d2@B =p@D@1(1&xcd1 d3@B2M@EzG@.-Vcd2 4@@E@Fr Ĝ@3wO;dn d5@?+ I@F-V@3+ Jca d6@>E@GLj~#@2Ec 27@=o@GI7KƧ@27KƧo d8@?`A7L@G\I^5?@5B I^5cb d9@@!hr @Ft@6y+ cg !2:@@ ě@G8F@7K I^od1 ;@?\(@FV$/@6Qnd2 <@?-@GM@1\(n d=@? Q@GbM@0XbMca d>@?S@Gv$/@//-Vc 2?@@Zn@Grm@.Qo d@@?y+ @HM@0xFcb dA@? I^5@Ho@./wcg dB@?m@Ihr @-\(cd !2C@>lC@JzH@/ooe1 D@?L1&y@I`A7L@+-Vne2 E@>+ @G ě@.hr n dF@> =p@F^5?|@+33333ca dG@?s33333@FC@)=p c 2H@>33333@G\(@(9XbNo dI@=x@F/\(@+ =pcb dJ@=E@E\(@-B\(cg !dK@=ZG{@E/@/XbMcd1 dL@<XbM@EG+@,hr cd2 aM@<n@EOvȴ9@05?|ne1 dN@;tj@E ě@/U$/ce2 dO@;s33333@E C%@*$/ce3 edP@:x@Do@/Qcz2 edQ@:|(\@Dj~#@*šcz3 VdR@:(\)@DH1&x@-TzGch2 VS@@MV@F\(@(nO;n dT@@l@G V@%ٙca dU@?+ I@F;dZ@#j~c 2V@?1&x@F@#1&xo dW@A~"@F=p @%tcb dX@An+@Fx1&x@'߾vȴ9cg dY@@;dZ@FN"@)=p cd Z@?I^5?@G@"1'n d[@>͑hr!@G@Fca d\@?zG@Gm@`A7c 2]@@.O;@Gj~@dZ1o d^@> I^5@H=O;dZ@ 9Xbcb d_@=-@HBm@W =pcg1 d`@=E`A7L@HTE@"cg2 a@?Y"`@Ffffff@ O;dZn db@?bM@F+@hr!ca dc@>=p @FzG@ +c 2d@>S@FQ@ I^5?o de@@GlC@F~"@ ěcb df@@M@EE@["`Bcg1 dg@@@E@ ^5?|cg2 dh@@`A@E2 I^5@j~#cd1 i@?-@Gu\(@zGn dj@>2m@G(\?bMca dk@?`A7@Gn"?Sc 2l@@E@GE?ԋC%o dm@=p =@HBM?C$cb dn@+@GtKƧn dr@?kC%@FԛSSca ds@>l@F1'"`c 2t@=]p =@F$/-Vo du@? =q@FF5?|hcb v@?6t@G?|h =pn dw@> ě@F I^+ I^ca dx@?kC%@FSVc 2y@@PbM@F ě.zGo dz@>|(\@GMěScb 2{@=hr@HE;dZog1 d|@=+ I@G;dZ["`Bcg2 }@>M@F + 7KƧn d~@?_|hs@ERfffffca d@>E@EQ"Mc 2@=Q@E I^"|hso d@>F@Dr Ĝixcb 2@?Vu@DdS $/og @?p =@EG{$6En d@?Vȴ9X@EuQ&XbMca d@>-@DGz'`ěTc 2@>Ƨ@D\C%vo @=x@DI^5?) =pn d@vȴ@C1&x+5?|hn d@?8Q@B1'+O;dZca d@?!7Kƨ@Bqo(|hsc 2@?,@Afffff)-Vo d@@X9Xb@B9XbN,vȴ9Xcb 2@@@CMp =*\(og @? =p @BǮzH&33333n d@>\)@Bq$/$1'ca d@="@B Ƨ#Mc 2@=Q@AR"G+ Io @<tj@B7KƧ%n d@;g+ I@A&x%Sca d@;Q@A)x')xc 2@:x@@Q' ^5?}o d@:@n@B:^5?|&+cb @<zH@A;dZ(vȴn d@<\(@@qo*/-Vca d@<<(\@@~Q,lCc 2@;rnO@@\(-So @(9Xb0;So d@=MV@?I7KƧ1 ěcb d@=o@?>5?|3Ecg d@> n@>i7KƧ3^5?|cd @=lC@>$/5G-ne d@=tj@=69Xbcz @ =p 7VEnh2 @9S@?+12mn d@8C@?[S1-ca d@7$/@@.O;1lCc 2@7r Ĝ@@"`1b`Ao d@81l@?Q/&fffffcb d@7У =q@@5Q-vȴ9Xcg d@8tj@@,1&y*-cd d@7pbM@@vȴ9X)W =pce @7$Z1@@M&kQnz @6$/@?߾vȴ92/wn d@5~Q@@]p =2tj~ca d@4~"@@fȴ9X1o\(c 2@31&y@?zG1)lDo d@4p =@@ 3˅Qcb @4rm@@+ I0"`n d@3Vt@AzH/Sca d@2E@A&x/vc 2@3Q@B=/w0 I^5o d@3-V@@\(,G{cb @1fffff@A+/ C%n d@1-O;dZ@Bn/%`A7Lca d@2hr@C%-Rc 2@2;dZ@CQ.(\o d@/`A7K@B5?|.KC%cb d@-hr @BU$/0j~cg1 d@.xQ@C~5?|.Jncg2 d@-7+@BƧ1Gzcd1 @2S@Btj~+'lCn d@3Ffffff@CdE)aGzca d@4tj@C ě*lCc 2@5;dZ@D,1&y)Qo d@3l@Ctj~&hr cb 2@4)x@Bz1'&bMog @5Jn@C<(\, ěTn d@6t@Cm/w-KC%ca d@6lI^5?@Co0$Sc 2@7h9Xb@C`A7L0XbMo d@7-V@Btj~,+cb d@7ilD@B8tj.C$cg !2@6A$/@Btj.~"od1 @8}E@A\(/ I^5nd2 @5+C%@Cvȴ9X0hrn d@4\)@Cش9Xb1ca d@5^"@DS2;dZc 2@549XbN@D12nOo d@3kQ@Cš2Q&xcb 2@3CnP@CěT3+ og @5E@DGz3En d@6$@El3kƧca d@5+ I@Fl2Mc 2@6p =@Fg-233333o d@6\)@E9Xb4cb d@7O;d@F>vȴ9X4bMcg ad@9p =@F9+ 57Kƨcd1 Vd@7t@F5?|4Rcd2 ed@9o@F\(5 1&yce1 ed@7"`B@Gy7KƧ4^5?|ce2 Vd@9@ěT@Gp ě5Gzcz V@4kC%@F =q3`nn d@3@Ft3 xca d@39XbN@F333331c 2@2 I^@G%?|h1;dZo d@2]/w@F&x3|hscb @2"`B@FV5nsg @3J=p @Ftj0fffffn d@2E@Ftj~/nca d@3E@F=V,Qc 2@3ȴ9X@FH9Xb*+ Io d@2c$@EJ~".t9XbNcb d@1+ I^@EnP0 Qcg d@/ؓtj@E-V/Rcd !2@/$/@ElC-8Qoe1 2@.nO@E"0\(oe2 @5Vu@FhQ-9XbNn d@6$tj@F,%Sca d@6NO;@GZn,bMc 2@6W+@GI^5?.2-Vo d@77Kƨ@FHQ-+ cb d@8\(@FwlC+)lDcg1 d@7cS@ES-LI^5?cg2 @6i^5?}@G+ J)Fn d@6n@H^O;)=p ca d@7vȴ9@Hn+' c 2@8dZ@H]O;dZ'/-Vo d@5u\(@HdZ)J=p cb 2@4hr!@Hx'DSog @6+@Hj~#$$/n d@7Q@H;dZ"tjca d@6$@HQl c 2@5wKƧ@HI^5?Qo d@8QR@I'+!KƧcb d@9"`A@I nMcg d@:333333@H"`BbMcd1 d @9S@IA7K O;dZcd2  @6dZ@GZ1>vȴ9Xn d @5Z1@G I^>vȴ9Xca d @6v+ J@GVFc 2 @7F$/@F+lCo d@4C@G#SnPcb d@3zG{@FVZ1'cg d@2hr Ĝ@Flvȴ9cd !2@2n@F=O;dZ# =poe1 @16E@FS~"ne2 @6*~"@G7-+ In d@6S@F~"tj~ca d@5$/@F`A7nc 2@4M@Fv O;do d@6=p =@G9XblCcb d@5Լj~@G" I^5?cg d@5dZ1@G nPcd @6fffff@ESnPn d@5t@DO;dZSca d@6Tj~@DnVuQc 2@7Hr Ĝ@DQo d@6A7K@D$9XbMcb d@7nO;@DLhrScg ad @7G{@CZ1&xcd1 Vd!@8U?|h@D|hs"`Bcd2 ed"@9(r Ĝ@CpA7K+ce1 ed#@9-@Dhr!%Sce2 Vd$@: I^5?@CE5?|hcz V2%@;Vȴ9X@C9XbNnPoh &@5 I^@CVuEn d'@69XbN@CnO;+ Jca d(@6j~#@CěT?zGc 2)@6;dZ@CVu? =po *@55?|h@DKS?O;dn d+@58Q@DC%@"`Bca d,@4+@DRnO@ I^5c 2-@3ݲ-V@D-@Qo d.@4CnP@EU\(@tj~cb d/@4[dZ@E(\@ ^5?|cg1 d0@4-@E"`?+ Icg2 1@5@DJvȴ@n d2@5n@CC%@Rmca d3@5$/@CC@G{c 24@5Stj~@B^5?|@ I^5o d5@4@DGz@Lcb d6@4G{@D1&@ I^5cg ad7@6(\@DlD@ + Jcd1 Vd8@4\)@E?;dZ@{lCcd2 ed9@6S@EyXbM@!ěTce1 ed:@45\(@E5?|@ =p ce2 Vd;@5ao@En@!ěTcz V<@5 =p@BE@nPn d=@5tj~@B/-V@;dZca d>@7 1&y@An@ QRc 2?@73E@ABm@ěSo d@@4zG@B Ƨ@p =qcb 2A@4 =p@Bg+ I?+ Jog1 dB@3F$/@BCnP@+ Jcg2 C@7$/@BKC%@Sn dD@8R@B$/?$/ca dE@97Kƨ@AlC@Ec 2F@:]/w@Av@ |hro dG@95?|@B\(?Scb dH@:vȴ9X@Ba7Kƨhr Ĝcg I@;-@B 7KƧ𿺟vȴ9nd1 dJ@:,C@BzG{Qcd2 dK@< ě@AlC|hrce1 !L@;-V@B-Effffffne2 !M@:#S@@-V?En dN@;S@@i+ @\(ca dO@>5?|@AlI^5?@nOca dZ@>Z1'@A =p@ Ec 2[@?rm@Ax@%So d\@>ǮzH@AzG?1&xcb d]@?"`@A}hr!?pbMcg ^@?`A@AO;dZC%nd1 d_@? ^5?}@@ =pncd2 d`@?t@AXbMnce1 !a@?jn@@vȴ9hr Ĝne2 !b@==E@BO;d@"`n dc@=N+@B\I^5?@8Qca dd@=ؓtj@At@33333c 2e@>fffff@B\)@tjo df@;+@B\(@;dZcb dg@<KƧ@C"@Ƨ-cg dh@;+@BdZ@! ncd !2i@;z1'@B*~"@!-Voe1 j@vȴ9X@( I^5o d@@`A7L@?@A7K@%GzHcb 2@@/-V@?)x@%xQog1 d@A2-V@=lC@&Gzcg2 @B%S@@vE@$Rn d@B޸Q@@y"`@#&xca d@C3 =p@A$/@%$/c 2@C@AnO@%^5?|o d@CA7K@@kdZ@ \(cb d@C&x@?ql@GzHcg @CkdZ@>lI^5?@ xQnd1 d@BnO@>nP@ncd2 d@C?-V@=MO;dZ@}Ece1 !@BG{@=@`A7Kne2 !@Bݲ-V@Aj~@%"`An d@C(Q@B4zG@&1&ca d@Chr @B$j~@)xc 2@Ci@B|I^5?@+# =po d@B|hs@BbM@%xcb d@C-@C~"@"I^5?cg d@BƧ@C7KƧ@"*~"cd1 d@C+ @CFx@"ncd2 @B1&y@A+ I@*-n d@Bpn@A^5?|@-["`Bca d@BS@BLj~#@.Rmc 2@B1hr @B/@0GlCo @A^5?|@BG{@,+ n d@AR-V@C=V@-O\(ca d@@E@CTS@+1&c 2@@~"@C8\)@)1&xo d@AC%@CQ@,Fcb @@$/@CZ1@,Mn d@? I^5?@C;dZ@+tj~ca d@?=E@DMV@)hrc 2@?׍O;d@D˥S@*-Vo d@=S@C$/@-eScb d@=l@C0ěT@.+cg !2@=vȴ@B&x@-t9XbNod1 2@=^Q@C4zG@0/od2 @>F@DC33333@'GzHn d@>R@D;dZ@%`ěTca d@=|1&@D陙@#-Vc 2@< ě@Ds@#Mo d@?m@D$/@#333333cb d@@1&@D;dZ@$tjcg1 d@?+@DV@!B I^5cg2 @=Ao@E$/@#tjn d@<8F@EbM@ Vca d@<-@EěT@{lCc 2@=E@Eٙ@+ Jo d@;E@FR I^5@!!ocb d@;G{@Fu`A7L@$ I^5cg1 d@:xQ@Ff-@1&xcg2 d@9M@F lC@$nOcd1 @x@D`A@C$cd1 Vd@<1'@C+@tjcd2 ed@>Z1@Dtj?Qce1 ed@=7KƧ@C1'?$/ce2 Vd@>&$/@D vȴ?5?|hcz V@;`A7@Eo@j~"n d@:Q@EͲ-V@tj~ca d@;=/w@Evȴ9X?7KƧc 2@;R@FYx?333333o d@9Լj~@FsS@"`Bcb 2@9k I^@FnzG@ Eog1 d@8vȴ9@FE? I^5cg2 @:p =@E` =q˥Sn d@;~vȴ9X@EklC/vca d@:@E ěc 2@9LI^5?@Ehr O;dZo d@;S@Dvȴ9XO;dZcb d@:g+ I@DZnhr!cg d@:=p =@D"?tj~cd @;Q@FnP ln d@:>"@Fu\(dZ1ca d@:\(@F97KƧ1'c 2@;7Kƨ@F^5?}dZo d@:=p @G9lD =qcb d@:F-@GElcg @;-V@G_v ěTnd1 d@9NzG@G;dZbMcd2 d@:m@GQMce1 !@9n@HEVune2 !@9/w@F'+n d@: =q@EG{ y"`ca d@:4zG@F;dZ";dZc 2@99"`@G&x"N+o d@8tj~@EQ!1'cb d@9>Q@E@n$hr Ĝcg d@:i^5?}@Dj~#$?|hscd1 d@7G{@DS%\(cd2 @;a$/@F#RnOn d@;1'@Gal$ca d@;$/@GAo';dZc 2@;tj@F( ěo @;@GKƧ)r ěn d@;\1&@G-,PbMca d@9XbN@G hr.XbMca d@?"@FLhr-p =c 2@>O;@Etj,:^5?|o d@?Vu@G =p-(r Ĝcb d@@ ě@G|hr*5?|cg ad@@nO;@G9XbN(ٙcd1 Vd@?B\(@Ghr!(Qcd2 ed@@y7KƧ@FI^5?&+ce1 ed@?Vȴ9X@GQ%~"ce2 Vd@@9Xb@Go;dZ$p ěcz V@?hr!@FS/+ In d@@R@EJ1'/ =qca d@@@EE-7Kƨc 2@@pbM@D{Ƨ,sEo d@@Xtj@E!&x1=/wcb d@@Q@EÕ$1Qcg d @@KC%@FX1&x1\)cd  @A"@EkC%,n d @A1'@E)+ +-hr!ca d @A`A7L@E/(|hsc 2 @Aj~#@F>Vu)no d@B2 I^5@Dtj-7Kƨcb d@B n@Db\(.ěTcg d@B1hr @C/-1'cd @BI^5?@CE-Sne d@CUS@Cm/w/7KƧcz @CQ@C3tj~07KƧnh1 @C5?|@CpA7K.^5?|nh2 @AVu@E_\(&1'n d@BC =p@E^5?|$sEca d@AVu@EzG" ^5?}c 2@A2M@ER"["`Bo @BG{@E;dZRmn d@A33333@E+Jnca d@BVu@F ětj~c 2@BzG@Fx@no d@Am@EO-Vy"`cb d@A2nO@Dӕ$nPcg1 d@A1&x@E-Vucg2 d @AL@D+cd1 !@An@F+vȴ9n d"@BGz@G7KƨSca d#@A"@GpbM -Vc 2$@A ě@GdE xo d%@A7Kƨ@H6ȴ9Xtjcb d&@B8Q@Hxxcg d'@Bfffff@ISS333333cd1 d(@A1'@IVu Qcd2 )@AlC@GgzHzGn d*@A+@G`nQRca d+@A(\@GQ?hr Ĝc 2,@Bttj@H333333?tjo d-@AQ@Fvȴ9?|1&ycb d.@Aȴ9X@F=p =pcg d/@A&x@EyXbMӿ;dZcd !20@AI^5?@E =p?+ oe1 21@A/@D\(7KƧoe2 2@AX\)@HPěT?Mn d3@Av-@H`A7?|hrca d4@ADZ1@HQ@tjc 25@@"@HA7K@ &xo d6@AS@IM?vȴ9Xcb 27@ATZ1@I+ΗO;dog1 d8@A/;dZ@J1&x@QRcg2 9@A ě@Hvȴ9@xFn d:@AKƧ@HVȴ9X@j~"ca d;@A1&@Hfffff@ =qc 2<@B@ =q@I%?|h@nO;o d=@B"\(@Gp =@+ I^cb d>@B C%@G;Q@O;dZcg1 d?@B@Ge`A7L@O;dZcg2 d@@B1&@F1&x@^5?|cd1 A@A6ȴ9X@HI^5?@Qn dB@A2\(@IuS@ 1&xca dC@A,I^5?@I$j~@"nc 2D@@I^5?@H"`B@#Vto dE@@zH@I =q@;dZcb 2F@@C@J1o@;dZog1 dG@@Vu@J/@!zGcg2 H@AS@IYlD@$|hsn dI@AƧ@I@''-ca dJ@AΗO;@I$/@)@c 2K@B + @J1$/@(So dL@Bd9XbN@H=p @'H1&xcb M@BwKƧ@H 1'@$Õ$sg N@AQ@Iu@+G{n dO@A&x@InO@-^5?|ca dP@By+ @Itj@/mc 2Q@Btj~@I7Kƨ@/xo dR@AH1&x@I@0$/cb dS@Avȴ9X@Jk I^@1,I^5?cg dT@@x@J`A@2+C%cd U@A ^5?|@Kȴ9X@3r Ĝne dV@@$/@K5`A7L@4-cz W@@7O;d@J@4&xnh1 X@@@KdZ@4 =qnh2 Y@BƧ@J\(@/:^5?|n dZ@CěT@IlC@0.+ca d[@CGz@I1'@1hr!c 2\@C0A7K@J=p @2So d]@D'zH@JVt@/ =pcb d^@DRm@JnO;@,5?|cg d_@DQ@K"@,ncd1 d`@DM@I33333@+߾vȴ9cd2 a@CƧ@IKC%@2?|hsn db@DR@IKlC@3bMca dc@DO-V@I1&@4-Vc 2d@D;dZ@JR ě@3W =po de@DC@H-V@4vȴ9Xcb df@D\(@HzG@5cg dg@E-@H"M@5bMcd dh@E`A7L@HME@5~"ce i@FQR@G+ @6bMnz j@Dn@J9@53n dk@DCnP@JޗO;@5-Vca dl@Er Ĝ@J-@5`A7Lc 2m@Ec$@JE@68Qo dn@C1&y@JE@7-cb 2o@D8bM@K{Q@7+og p@EFfffff@KC%@5O;dZn dq@Evȴ9@K$@5@ěTca dr@Fdj~@Kz=p @4Gzc 2s@Fv@KQ@3/wo t@FVu@K33333@3=-Vn du@Fl(\@JM@1vȴ9ca dv@Fzvȴ@KMhr!@0+ Jc 2w@FM@KnO@0$/o dx@F C@J!&x@1qlcb dy@FR\(@IV@0 lDcg1 dz@Fvȴ9X@Ij~#@2ovcg2 {@G\(@KTtj@0J~"n d|@G=hr!@KnO@.׍O;dca d}@GV$/@KO;d@+ȴ9Xc 2~@GglC@K\(@+u?|ho d@Ghr@L4tj@/ ěcb 2@Ho;dZ@KQ@/hr Ĝog1 d@G^5?}@LsE@1NVucg2 @G]p =@L#$@*-Vn d@Gt@L ě@'J=p ca d@H2m@KěT@' 7KƧc 2@H;lC@KlD@%Fo d@G I^@LƧ@%j~#cb d@GR@L^5?}@"ocg d@HIx@Ls =p@!zGcd !2@H+@LlC@"I^5?oe1 @HVt@L9Xb@1&yne2 @H+ J@KbM@(ixn d@Ibm@Kx@(&xca d@Iffffff@J`A7@)c 2@I/w@Ju?|h@'Z1o d@I@LO;d@)+cb @HO;@JQ@++Qn d@HbM@J&x@,WO;dca d@H+@I33333@*~"c 2@HbM@HO;@*EQo d@Hx@J"nO@/+ Jcb d@Hl@Io@0O;dZcg d@H `A7@I5?|@1tj~cd !2@GQ@J:vȴ@1xoe1 @H*vȴ@I:=p @2Gzne2 @H`A@IΗO;@)#Sn d@G~"@Ig =p@'-Vca d@H5$/@IGKƧ@$dZc 2@HAo@H-@#vȴ9Xo d@Gtj@IS@&!ocb d@F˅Q@Iovȴ9@# =pcg1 d@F^5?}@IlC@(tj~cg2 @H^5?}@IE@#n d@IQ@Ivȴ9@!1&ca d@IKƧ@I?vȴ9@"J=p c 2@IbM@HVu@ lDo d@IQhr @Jo\(@  I^cb @IlC@IIx@$j~#n d@J` ě@HE@%Mca d@J"M@HE@%nzGc 2@J{Ƨ@G ě@$[So d@J\(@Htj@(wKƧcb d@K =p@HiXbM@)tjcg d@KQ@Hfȴ9X@(Ձ$/cd !2@L I^@HnP@'Soe1 @L+Ƨ@G1&x@)z^5?|ne2 @IO;d@Gj~@&aGzn d@IA&x@GIx@&Jnca d@I-E@G9Xb@#aGzc 2@IO\(@FpbM@"o d@HZ1@GFfffff@'9XbNcb @HM@Gx1&x@!+ n d@HޗO;@GBnO@oca d@IzG@G-E@Sc 2@I ě@FQ@ =po d@Ho;dZ@G&x@~"cb d@Gj~@G`A7L@Ecg d@Govȴ9@Hy"`@;dZcd1 d@GJvȴ@G3E@hr cd2 @Jȴ9X@G\(@`A7Ln d@JE@G-V@ixca d@KbM@F$/@Vuc 2@KDZ1@F ě@-o d@K;dZ@H:=p @C$cb d@JGz@Hr Ĝ@ȴ9Xbcg d@KE`A7L@IS@ocd !2@KO;@Iql@\(\oe1 @KzG@J|hs@fffffne2 @JVu@FO;dZ@ /wn d@KAo@F,C@!/wca d@JXbM@EV@ nPc 2@K=O;dZ@E ~"@ I^5?o d@KP ě@F-/w@$/-Vcb d@KbM@F?|h@%vȴ9cg d@L`A7@FE@# ěcd !2@Lև+ J@FO;d@$8Qoe1 @Lp =@Gr Ĝ@"-Vne2 @J@ =q@Ej~@)lDn d@IzH@EE@\(ca d@J1&@Dj~#@/wc 2@J8tj@D^+@O;do d@I!Gz@ES@(\)cb @J)x@EwO;d@n d@J.O;@EdS@ Eca d@J@E-@+c 2@Jm@Ez^5?|?9XbMo d@IQ@E`A@ȴ9Xbcb d@HS@E]/w@ $/cg ad@Hٺ^5?}@DO;dZ@ |hrcd1 Vd@Hj^5?|@EV@$/cd2 ed@HHF@DZvȴ@|hrce1 ed@G+ @EnVu@ I^5?ce2 Vd@Gfffff@D;dZ@lDcz V2@G8\)@Dmhr!@noh  @KIx@Etj@ zGn d @K"@F.+@hr Ĝca d @L?;dZ@Ehr?9XbNc 2 @L+ J@E ě?j~"o d @L\j~#@FzG@ ;dZcb  @LDtj@E  I^@^5?|n d @L =p@D`A7?`A7Kca d @LE@D+ I?;dZc 2 @LAl@Cw+ I?KƧo d @MO;d@DdZ@ěScb d @MQ@D~"@"`cg  @N-@Dtj~@1&xnd1 d @M@Dfffff@6Ecd2 d @NiXbM@EKQ@+ ce1 ! @NA$/@E5?|@_;dZne2 ! @KsnP@D=E?`A7Kn d @Jo@ClC?j~"ca d @Jҏ\(@D%\(+ Ic 2 @Jv@DtjZ1'o d @JLI^5?@Cš?^5?|cb d @J`n@Cctj~@Scg d @Jl@B =p@ffffffcd d @J@B@A7K@ -Vce  @Jj~@AE@lCnz  @K$/@CǍO;dQn d @K Ƨ@Dtj vȴ9Xca d @JW+@D5\(,1&yc 2 @JEQ@D+ Y+ o d @KpěT@C|hsnOcb d @KO|hs@BSocg d @K8tj@Cn ěcd  @I`A7L@CS=p =n d @I-V@CO;%Sca d @HC%@Do;dZI^5?}c 2 @H$zG@D+zGo d @HGz@CERcb d @IS@BA7KKƧcg d @H"`B@BMTEcd1 d @IBm@C1o\(cd2 @Io@D"hr!n d@HS@ED9XbNvȴca d@IR@Ehrnc 2@I+ @Ehr! =po d @HQ@EtbMcb d @H0 =q@EQ?bMcg1 d @Hvȴ9X@Du`A7L`A7Lcg2  @Hx@Fi"`bMn d @HE@G ě+ Ica d@H1'@G\(-Vc 2@H@Gr Ĝ =po d@H`A7L@GE$/vȴ9cb d@I%`A7L@FF ěTcg d@I'+@GQXbMcd @Hx1&x@G,1&ymne d@HR I^5@GF+ J!y"`cz @H;dZ@GU\(#A7Kƨnh1 @G+@GO|hs"I7KƧnh2 @I-V@G33333mn d@HV@H9"` ěcaad@H(\@H9+ Qcabd@H9Xb@HA7Kǿ|hrc !2@I\(@I I^\(o d@I=/w@H/?;dZcbad@I>vȴ9X@H?|h?ocbbd@Itj@HnO@bMcgad@IbM@GqR@tjcgbd @HXtj@H9XbN@tj~cd1ad!@Iv@Gj1'@ Ƨ-cd1bd"@I@Hx9Xb@ ^5?|cd2ad#@H^zG@Gg-@7KƧcd2b$@Hr ě@IZn׮zGn d%@Hy+ @J ěEca d&@H@Jl1&y?Ec 2'@HTZ1@J^Vu?nPo d(@Gx@JWzHZ1'cb d)@GZ1@J6+ Jcg ad*@GE@JVu -Vcd1 Vd+@G\(@I ě =p =cd2 ed,@G` ě@JnPkQce1 ed-@G`A7L@Ir\(2-Vce2 Vd.@Gctj~@Ip ==p cz V2/@GDS@It"`oh 0@I>zG@J =p?lCn d1@Ivȴ9X@K-/w?=p =ca d2@HS@K"`B@hr!c 23@H+@Ktj~@ QRo d4@J$/@K}E?;dZcb d5@JKƧ@JC?^5?|cg !26@JQ@Jj~"@1&xod1 27@KFfffff@K+ I^?񙙙od2 8@H+ I@L/?dZ1n d9@H0ěT@Lȴ9X?Sca d:@GG{@L$/?p =qc 2;@G9XbN@LCSdZ1o d<@Hzn@ML?vȴ9cb d=@IXbM@MmV@tj~cg d>@HbM@Mə@ /wcd d?@H˥S@N7KƧ@Qce @@IqGz@NlC@nnz A@G @L-?٩lDn dB@F-V@L\(ca dC@F@@K+噙c 2D@F}hr!@KxQQo E@EbM@K"`~"n dF@E_\(@K;SϿEca dG@EU?|h@K I^5ěSc 2H@ETj~@Klhr+ Jo dI@Dhr@KNVu I^5?cb dJ@Dvȴ9@Kvfffff?=p =cg1 dK@D=O;dZ@KF$/cg2 L@EY"`@JWO;d Sn dM@Ej^5?|@Jhr!fffffca dN@D =p@J9x49XbNc 2O@D8F@J?;dZto dP@Eo@I\1&H9Xbcb dQ@E;C%@I-V XbMcg dR@EVE@I =pnOcd S@DzG@JPbM}En dT@DSS@JKS$/ca dU@DL1&@IQ! nc 2V@DR@IMp =!-Vo dW@DrnO@JE"ncb X@C I^5@I\hr!p ěn dY@Cȴ9X@H\("y"`ca dZ@C-V@H=p %-Vc 2[@D0@Gj~#%Vuo d\@B`A7L@Hvȴ"KƧcb d]@B I^5@GЃn#\(\cg d^@CO;d@GT/!1&xcd1 d_@Atj~@G\)"/cd2 `@C$/@Im'Rn da@D6x@Hٺ^5?})hrca db@Dtj@HV)tc 2c@E1o@HBm+Z1'o dd@D#tj~@Iq7Kƨ+ =pcb de@D =p@J  I^*dZcg df@DuQ@Jvȴ-;dZcd dg@D$/@K5`A7L,1&xce h@E&x@K vȴ,zGnz i@EL@H;dZ'qln dj@F\(@Htj'/-Vca dk@F; I^@H =p&^5?|c 2l@F =p@G&2 ěo dm@FNzG@IB-V%aocb dn@F6x@IGz&`Acg !2o@F@A7K@JA7K) =pod1 p@FS@JsE%+ Ind2 q@EƧ@GE%ȴ9Xn dr@EƧ@FE%6Eca ds@El@Fe$/'(\c 2t@E1&x@ElC'(r Ĝo du@EVu@F-"5?|@G\)@KƧcg2 d#@Fttj@FO\(?5?|hcd1 $@F#tj~@I0bM?`A7Ln d$@FM/w@IXbM?Qca d$@Etj~@IQ@Qc 2$@EV-@I5?|@vȴ9o %@EKƧ@J~+@\(n d%@E=p @JbM@-Vca d%@EM@KX1&x@;dZc 2%@F!o@KO;dZ@lCo d%@E-V@J"`A@1&xcb d%@FTZ1@JOvȴ9@Qcg ad%@FMV@JQ@6Ecd1 Vd%@F9XbN@JzG@bMcd2 ed%@F㕁$@JS@lce1 ed%@G~"@JIx@TEce2 Vd%@GR@JC@lCcz V&@E(1&x@KR@1&n d&@E.O;@L+&DSo d 65@BS@BZ1) C%cb d 75@B+lC@B^5?|);dZcg d 85@BQ@A7KƧ,5?|cd1 d 95@A7KƧ@A\((KC%cd2  :6@D;Q@BP =q$ln d ;6@DZ1@B5Q$p =ca d <6@E&+ J@B bM!+c 2 =6@E-@A&x 7KƧo d >6@E[dZ@Bȴ9X&`ěTcb d ?6@E@B+ I)G+ Icg d @6@E}-V@CC33333*Ccd1 d A6@Ev@Bhr*Ձ$/cd2  B7@EU`A7L@BO;d \1&n d C7@Ex\)@B+Qca d D7@D׍O;d@BOv!oc 2 E7@D|hs@AVuDSo d F7@E+@C2nOcScb d G7@EQ@C(r Ĝu\(cg d H7@Fk I^@Btj,1&ycd d I7@FzG@B"`+ce  J7@F`A@A&x`A7nz  K8@D@ěT@B{Q9XbMn d L8@Cl@B:vȴÕ$ca d M8@Cr ě@AlnOc 2 N8@B\(@A;lC~"o  O9@C;dZ@A2 I^5+n d P9@CE@@hr |hrca d Q9@DB\(@@%$/ bMc 2 R9@DS@?j~#-Vo d S9@C"@@!F$/cb  T:@DYXbM@@.+#Qn d U:@DO;dZ@?$j~"ca d V:@Efffff@?ӶE# =pc 2 W:@E@>և+ J#]-Vo d X:@DQ@?r Ĝ'xFcb  Y;@E7KƧ@@C#\1&n d Z;@FxbM@@tj""`Bca d [;@F7Kƨ@@x1&xhr c 2 \;@G1hr @@;ƧI^5?o d ];@F?|h@Aqhr #cb  ^<@F&x@@+Sn d _<@FI7KƧ@@K I^hr Ĝca d `<@FWO;d@?`A7xFc 2 a<@FnP@>lC=p o d b<@E =q@@;dZVtcb d c<@Efffff@@Ix $/cg d d<@Ep =@@+ + cd !2 e<@E@AlCSoe1  f<@D`A7L@@5?|Qne2  g=@Etj@>f$/=p n d h=@E7Kƨ@@F =p@=&- + Jn d m>@G~"@< =p!:^5?|ca d n>@HC@=;dZ^5?|c 2 o>@HF@@GzG@=tE$ I^5?cb d q>@HWKƧ@=aGz%zHcg1 d r>@G)@f-&xn d t?@H\(@>Լj~ ěca d u?@H-@=\)mhr!c 2 v?@I$E@=zGu\(o d w?@HE?|h@@`A7L=p cb d x?@HzG@@dj~vȴ9Xcg d y?@Hp`A7@AZ1 Qcd !2 z?@H1&x@Ab`A9XbNoe1  {?@GO;dZ@A bM^5?|ne2  |@@H (\@=1hr ?|hn d }@@H9XbN@<Q r ěca d ~@@Hrm@:Mhr!c 2 @@H9XbN@:9+ 1&o d @@G^5?|@;O;dcb  @@FnO@=1&xտ~"sg  A@HSnP@:hr zGn d A@H@9mO;dZoca d A@IdzG@9=p nc 2 A@IG{@8-VƧ-o d A@HWzH@9"`AY+ cb  B@I$/@:1&xǮzHn d B@JGlC@;E`A7Lnca d B@Jvȴ@; CTEc 2 B@K-hr!@:-Vȴ9Xo d B@J^5?|@lC!nd2  C@J>vȴ9X@;pbMEn d C@Jy7KƧ@;9+ \(\ca d C@J|C@9A7Khr c 2 C@J"`@9G-1&xo d C@Jtj@<Z1 I^5?cb d C@J-V@=^5?}hr Ĝcg1 d C@J8F@;G{?`A7Lcg2 d C@I+ @>p =qnO;cd1  D@I$@9r Ĝ$/n d D@I"`@71& ěTca d D@JbM@6\(Z1'c 2 D@J I^5@5/w^5?|o d D@I>Q@7 ěEcb d D@I# =p@5Vuj~#cg d D@IE$/@5 7KƧnO;cd  D@I(9Xb@3QƧ-ne d D@Ij~#@2+hr!cz  D@J2`A@3$tj=p =nh1  D@Iy"`@1nzG9XbNnh2  E@JQ@7EQ`A7n d E@K&x@6lI^5?-Vca d E@KbM@6EbMc 2 E@LGKƧ@6r-V\(o d E@JF@6)7KƧǮzHcb d E@JHbM@5,1&yVcg ad E@JiXbM@3͑hr!49XbNcd1 Vd E@Ihr!@5tjxcd2 ed E@I-V@2lChrce1 ed E@IE@4 I^1&ce2 Vd E@I7O;d@3LC# =pcz V F@Kvȴ9@8-VVn d F@L9XbN@8?|hsca d F@LͲ-V@9dZ =pc 2 F@Mh1&x@9ӶEqlo  G@LWlC@:!7Kƨn d G@L-V@;\(TEca d G@L1&y@ؓtjxca d H@L+ I@?/vc 2 H@KE@> ěo d H@Mvȴ9@?x 0 ěcb  I@K`A@?"`Bn d I@K@A7K@@"`tj~ca d I@JnP@@g =p O;dZc 2 I@J=O;dZ@@<1&lDo d I@K+#bMn d K@KAo@?m& A7Kcaad K@KDZ1@?Ƨ&cabd K@J I^5@?/w'1&xc !2 K@J*=p @? ~"&zGo d K@K=p @>~5?|%p =cbad K@K&x@>i7KƧ%|j~#cbbd K@KҰ ě@=bM(Ecgad K@KC%@=lC'Fcgbd K@LQ@=nO(N+cda!d K@LS$@>$/)`A7Kcdb!2 K@LͲ-V@<bM&O;oe1a2 K@LQ@=t(/woe1b K@LO;d@>TzG)1&xne2a K@L6fffff@?E+(\)ne2b L@J =p@@tj*I7KƧn d L@J+ I@@ "`,;dZca d L@IQ@@\(+^5?|c 2 L@I5\(@@ =p-zGo d L@I+@>C%,DScb 2 L@I,1&y@>̋C*F-og  M@IzG@AM)j~n d M@I&-@A~"(\(ca d M@I_;dZ@B:~")r Ĝc 2 M@H+ I@B9Xb*+o d M@I /w@AGz%xcb d M@H`A@@O;d$ =pcg d M@H`A7@@v! =qcd1 d M@H3tj~@@tj~& cd2  N@Jx@BT/)KƧn d N@JO;dZ@Bhr*Sca d N@Kr Ĝ@Bա+Y+ c !2 N@K&ȴ9X@BOv,Eo d N@J6$/@CF(P`A7cb d N@Jj=p @D?\(),1&ycg1 d N@Jtj@CVt% I^cg2 d N@InO@DnP*Mcd1 2 N@K~+@C4/*+oxt  O@Iҏ\(@9-O;dZ2 ěNa  P@JzG@ExENa d Q@Bn@CnO5nc1a"d Q@B-V@B$/5~"c1b"2 Q@BsS@C bM6ۥSo1a2 Q@A@BƧ6^5?|o1b2 Q@Cv@CVE5&xo2a2 Q@B1&y@Bv5zGo2bd Q@B;dZ@BěT4Ec2ad Q@A`A7@Bx4O;dZc2b2 Q@Av@Bp`A75qRo3a2 Q@@(\@B7KƧ52-Vo3bd Q@A5?|@C ě3zG{c3ad Q@AƇ+ J@C[dZ3$/c3bd Q@AxQ@BF2}/wc4a!d Q@A+@C7 =p2Yc4b!2 Q@A7KƧ@Bv1aoo4a2 Q@AěS@Bvȴ9X1 I^o4b2 Q@@Gz@B|I^5?2Qo5a2 Q@A$/@C I^51"`Bo5b2 R@H"@7ȴ9X5+C%o 2 S@9-@D&x@qlo 2 T@=R-V@Ie`A7LVo 2 U@?lD@I>Vu@+ o 2 V@>bM@K^Vu@/\(o 2 W@3TzG@E+52 ěo 2 X@=ěT@;i7KƧSo 2 Y@EO;@D%Q!wKƧo 2 Z@F5@JO;Co 2 [@; =p@BD/-Fo 2 \@AzH@F;dZ.tjo 2 ]@6~"@FޗO;$ ěo 2 ^@E@A.vȴ9X0dtjo 2 _@E1&@HV+ J/wo 2 `@8&-@E8tj@?|ho 2 a@AyXbM@Htj@-o 2 b@G3S@K--V@xFo 2 c@I~"@Bӕ$ݿvȴo 2 d@Dև+ J@A=O;dZ4Mo 2 e@A$/@M@*}Eo 2 f@EPěT@M0 ě =po 2 !g@EH9Xb@, ^5?}07KƧo 2 "h@47Kƨ@Ex#vȴ9o 2 #i@?߾vȴ9@H\(@'nOo 2 $j@=O;dZ@Ic$"tjo 2 %k@BQGz@AHF1hr o 2 &l@@f+ J@?-V)C$o 2 'm@Gx@H/wFo 2 (n@;-@B\j~#lo 2 )o@4mO;dZ@BE4MVo 2 *p@Ifx@H,j~#@-Eo 2 +q@DDzG@F1&@1 =po 2 ,r@:$S@G^5?}@=p o 2 -s@@ylD@E =q@/o 2 .t@?-@C# =p7Kƨo 2 /u@0v@D2-V3-Vo 2 0v@>-@>1&y@9XbMo 2 1w@F333333@MsnP@O;dZo 2 2x@;6+ J@In%^5?|o 2 3y@Cl@Invȴ9X@6=p o 2 4z@A @A-V So 2 5{@>+@>ěT,+ Io 2 6|@@|1&@DS@14zGo 2 7}@A|hs@8XF-Vo 2 8~@Go@>5?|5\(o 2 9@AlC@<nP+-o 2 :@HVu@M333333@+#So 2 ;@C@2stj~6+ Jo 2 <@BG{@< n? =p o 2 =@EI^5?@AQhr 7no 2 >@JY"`@+hr + =po 2 ?@< ě@GzG@(to 2 @@Bvȴ9@>;"`B(\o 2 A@3A$/@GKQ'I^5?o 2 B@B^5?}@@*=p nOo 2 C@,-hr!@FƧ+_vȴ9o 2 D@CS@FE@4vo 2 E@8͑hr!@B-@-Vo 2 F@Af+ J@?G+ I ^5?|o 2 G@C-V@@S1&xo 2 H@B`A7L@J1&x@3I^5?o 2 I@G1&x@BM+dZ1o 2 J@GzG@Kfffff@I^5?}o 2 K@D\(@F =q@82 ěo 2 L@@9Xb@A5`A7L?/wo 2 M@EWO;d@IV@8>Qo 2 N@3޸Q@E+dZ&Vo 2 O@F\(@Mdtj@+"`o 2 P@F;dZ@GzG{-,1&yo 2 Q@E;"`B@N\(@+$/o 2 R@2m@BS?"`Bo 2 S@BXbM@FFE@4hro 2 T@Av@N1&y@&lDo 2 U@Hs =p@E&x@)So 2 V@>ov@ES =p@3D/o 2 W@L I^@8zvȴ3 ěo 2 X@>>"@>dtj-Vo 2 Y@AV@JO;@5p =o 2 Z@@  I^@@ =p&Vuo 2 [@2m@E_;dZMo 2 \@>S@Cv@2vEo 2 ]@@uQ@@Jhr@29Xbo 2 x@JKQ@0+ 1lCo 2 y@BA7K@7nzG@r ěo 2 z@Jhr@8 =q4i7KƧo 2 {@Ctj@N+#=p o 2 |@1^Q@A1&'xo 2 }@@5?|@;P`A7KƧo 2 ~@6Q@?|hs?Z1'o 2 @9;S@CԼj~@ ěTo 2 @ I^o 2 @CS@6`A7@!O;do 2 @B =p@?+C%?nOo 2 @F1&@$O;d#mo 2 @DÕ$@A\(@no 2 @FT/@>V@vȴ9Xo 2 @A =q@CTE@2RnOo 2 @;AGz@DO;dZ@3VEo 2 @D;dZ@AV@%+ Io 2 @N1R@7I^5?$/o 2 @@7KƧ@@-Vfffffo 2 @@tj~@/9Xb9dZo 2 @=XbM@@-V@'+ Jo 2 @BI^5?@A9Xb@2E`A7Lo 2 @Gp =@LS o 2 @C-@Kqhr @:hr Ĝo 2 @Lش9Xb@@&$/ no 2 @8bM@5bM</wo 2 @A"`B@?n@-\1&o 2 @?-@@Nvȴ9X;b I^5o 2 @F/w@@/v@(I^5?}o 2 @9ѩl@7\(\xo 2 @?a$/@9~"*ȴ9Xbo 2 @;vt@6R2ɺ^5?}o 2 @A*=p @'zG5$/o 2 @D+ @Etj~@2j~#o 2 @8 ě@@-"=Eo 2 @IkdZ@Ebm@&\(o 2 @FƧ@)\(vȴo 2 @F$/@J$/.PbMo 2 @I`A@,9XbMdZo 2 @CQ@B}/w@0=-Vo 2 @Hn@"@&hr&\(\o 2 @;2 ě@0V1&o 2 @66ȴ9X@A7KƧ@ =Eo 2 @FIXbM@28F@ xFo 2 @=Dtj@8`A73-Vo 2 @6@Bv&hr!o 2 @Jtj@I@ěT?xFo 2 @DlC@L&x@3Ro 2 @HlD@D'zH@1(\)o 2 @L 1&@:+ Io 2 @Lk"`B@<"+ o 2 @6R@= ěT3.zGo 2 @Aq$/@2CS@%+ o 2 @E]V@Bȓtj@0)7KƧo 2 @C`A7L@@O;dZ@+ܬ1&o 2 @>"`A@BE^5?|o 2 @G ě@XbM 7KƧo 2 @B;dZ@C/w@4"`Bo 2 @9\(@?}-V@%w+o 2 @G&ȴ9X@C/$Z1o 2 @6NVu@633333o 2 @:rnO@3䛥S@tjo 2 @/L@DgO;d(Ձ$/o 2 @6j~@AeS@&A7Ko 2 @JŁ$/@6R5bMo 2 @K;dZ@Jl@$^5?|o 2 @8;dZ@<nno 2  @J$@DE@$vȴ9Xo 2  @Etj~@LnO@/7Kƨo 2  @HR@I޸Q@`A7o 2  @Cr Ĝ@D$/@4xo 2  @@-@=ixMo 2 @Dtj~@H-V01&yo 2 @91l@;Z^5?|2Qo 2 @Ct9XbN@9\)@vȴ9Xo 2 @HzG@-^5?|Fo 2 @7+@<KƧ,\(o 2 @EěT@Cq7Kƨ1dSo 2 @K bM@?Q0Eo 2 @@$/@$\(1 Qo 2 @C.5?|@$bM5tjo 2 @JZ1@@lD@,1&yo 2 @;@Fo@61&xo 2 @Jݲ-V@09Xb So 2 @AZ1@22m>+ Jo 2  @I&x@E V@.lo 2 !@>x@&O;d3j~o 2 "@DnO;@E(\)@6 ěo 2 #@@!l@&(\+ Jo 2 $@Dhr@.[S6Qo 2 %@JGO;d@57Kƨ@!;dZo 2 &@JVu@H5Sٿ ěTo 2 '@A.vȴ9X@7x@4So 2 (@C$tj@Jn$/o 2 )@@;dZ@FES@9Eo 2 *@C6$/@9^5?}Ar Ĝo 2 +@Hx@BlD@.~vȴ9Xo 2 ,@?kƧ@7O;0so 2 -@Es33333@ ěT@?+ Jo 2 7@K1&@6zHno 2 8@>|1&@&m"tjo 2 9@AS@j~#)y"`o 2 :@CR@CQR@28tjo 2 ;@;l1&y@=(9Xb+nzGo 2 <@?KC%@@|hs$/o 2 =@>R ě@"&x(\o 2 >@DG+@(zG5o 2 ?@FE@BnQ4tjo 2 @@J+ I@JlC@%49XbNo 2 A@@bM@@nO"$/o 2 B@>j~@?-V#+ o 2 C@EO;d@7rnO@IXbMo 2 D@B =q@:ěT@$Stj~o 2 E@?*n@-1':U\(o 2 F@C~"@=nP@&޸Qo 2 G@E[Ƨ@N+@`A7Lo 2 H@C;dZ@G;dZ@6e`A7Lo 2 I@M*G{@9[dZ?Qo 2 J@C9Xb@2^5?}?o;dZo 2 K@K."@G`A7?KƧo 2 L@CУ =q@;\(@|o 2 M@1WO;d@E vȴ&+Qo 2 N@Hȴ9X@C|hs@(to 2 O@;-V@Aj~"@1\(o 2 P@=Ov@0S33333<"`o 2 Q@A3 =p@"# =pO;dZo 2 R@D /w@Gt@87KƧo 2 S@;Q@,vȴ=Z1'o 2 T@D~"@I7+@9)xo 2 U@CLC@GTtj@;{lCo 2 V@L/w@Ifffffj~#o 2 W@Ftj@?tj~A"o 2 X@0mV@Eqo?Qo 2 Y@DXbM@CVu5mo 2 Z@JS@Ltj~@!Qo 2 [@Jvȴ9X@Jϝ-VXbMo 2 \@E|@B# =p5|hso 2 ]@@s33333@2i^5?}.1'o 2 ^@5@ARZ1'o 2 _@E-V@$ I^50^5?|o 2 `@2XbM@D xxFo 2 a@Dߝ-V@&|j~#3mo 2 b@ES@@{S@lCo 2 c@7ȴ9Xb@B Mo 2 d@@ڟvȴ@??|h?Vuo 2 e@M`A@5~"-~"o 2 f@J\(@F I^5?:^5?|o 2 !g@8>vȴ9X@Ctj~@!1&o 2 "h@<$/@A]p =@%o 2 #i@IB I^5@K$/-Vo 2 $j@L hr@CZ1@o 2 %k@Gvȴ9X@:lD@W =po 2 &l@7 O;dZ@B$/So 2 'm@LkdZ@Ap =&ffffffo 2 (n@1"M@Ffx$߾vȴ9o 2 )o@97O;d@B5?|@(^5?|o 2 *p@E*1'@=|hs@nPo 2 +q@89Xb@HO;dZ2+o 2 ,r@H:=p @M ě@\)o 2 -s@@@ I^@"S$O;do 2 ?@E%Q@6Ƨ@&o 2 @@?A$/@@$=TzGo 2 A@B{lC@E81&x3 I^5o 2 B@L =p@H_|hs@#tjo 2 C@C]/w@&?|hs?\(\o 2 D@BU`A7L@E# ěTo 2 E@L+@AEvȴ9Xo 2 F@BG{@>fffff@nPo 2 G@JdZ@+vȴ9Xo 2 J@GAhr @AlC6~5?|o 2 K@@r\(@IR4\hro 2 L@9$@D(r Ĝ@#'-o 2 M@FX\)@Dd/@5tj~o 2 N@8-V@C~zG@O;dZo 2 O@)>"@EE0fffffo 2 P@L1&y@4k I^&|hso 2 Q@I1&x@@lC@ ěTo 2 R@K^vȴ9X@D+ =po 2 S@N Ƨ@5^5?|%Rmo 2 T@8tj~@A ě@$ ěo 2 U@OO;d@6Ov)5?|o 2 V@I>"@8hr 6XbMo 2 W@K%?|h@7p =q@!ۥSo 2 X@A.Vu@4-V?`A7o 2 Y@A ě@9E@\)o 2 Z@;0`A7@<\(8+C%o 2 [@?p =@ID9XbN@4 ěo 2 \@FGz@9z^5?|?-Vo 2 ]@E1&y@A I^@,tj~o 2 ^@Azvȴ@*7Kƨ8 o 2 _@Hߝ-V@,RMo 2 `@Fz^5?|@&xw+o 2 a@7+ I@)`A7L@33333o 2 b@LV@B5$/?zG{o 2 c@J)@J>+@$/o 2 d@Ij~#@/hr!?o 2 e@8=E@4^5?}@(fffffo 2 f@55?|@1u$/@lCo 2 g@HdZ@:O;dZ@""`Bo 2 h@M$/@6Q1&xo 2 i@Dvȴ9X@?Q@&w+o 2 j@9nzG@9dZ5;dZo 2 k@LzG@JB\(@ I^5?o 2 l@F?|h@F5$/1%o 2 m@E"nO@&xXbMo 2 n@N{Ƨ@; I^50;dZo 2 o@H-V@8`A@$Z1o 2 p@EƧ@CLhr@5vo 2 q@GylD@:-@o 2 r@L =p@J 1'?;dZo 2 s@FQ@Eq7Kƨ2$/o 2 t@J-@/M@aGzo 2 u@Khr @A^5?}+`A7o 2 v@?x@A{Q@.\(o 2 w@?bM@K"@1`Ao 2 x@=Rm@Ie`A7L)`A7o 2 y@Bt@A$j~4Z^5?|o 2 z@DE@BbM1I^5?}o 2 {@>tj~@HQI^5?}o 2 |@F\(@Cm@3 =po 2 }@.vȴ9X@E/wQo 2 ~@@p =@#Q@j~#o 2 @4 =q@?ao@ O;dZo 2 @5\)@IeQ0# =po 2 @@u`A7L@$R@!$/o 2 @FjG{@:S@XbMo 2 @Ivȴ9@@o@ O;do 2 @K`n@@Fȴ9X?އ+ Io 2 @L2-V@3ƧVo 2 @> =q@);dZ'߾vȴ9o 2 @LlD@E^O;@.zGo 2 @<3E@*~"vȴ9Xo 2 @8 n@8Q;Qo 2 @JQ@: =p6Qo 2 @F-V@Kn/# =po 2 @5(\@CHQ P`A7o 2 @???333>?333>?333>?333>??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????AffA\)A33A(AˮAzAAAAA=qAA=qA(ApA\A A AAAAAAAA\AAl(AsAGAAHA\)AAQAuGA=qA\)ApAAA\)AoAQAAzHA{AzAffAsAVffAt(A\AAAAAA(AAAzA=qA\)AA=qAAAAHAffAffAA(A=qA~ffAlAx(AbRA\(AXAEAWAZ=qAAAK =A]pAb\AhAw33A[AYAFRAMAK\)AQGAJ\AS33AO APQADzA4AIA7 =A?A;33A>HA4zAT(A3\)AR{Ac =AxA@AUAV=qAk33AHAg33As33AIAXAaAg Aw =AdALAS\)AXAMAIAWAIGAk\)AeAD(AffAW A\APQAZRAcAnRAo =Ag\)AtAAffAAqAtQAApAh(AmAhA{AAA =AHAA =AAA=qAGAQA =A\AffA33AA33AGApAA AHA\)AA33AA(AQAGA\AAAAGAAA\AzA{AGAzAAGAAffARAA AƸRA\)AÙAAA=qAA=qAA33AGA\AͅAQA(AəAѮAQAB{B\AAAAA AAәAGABBARAAAGB BGB =BBB!=qB{BRB B 33BzB#ffB+\)B8RBAApABQB{AAffAzAQAA\AAffA{AGAHA33A=qApBB QB RAʣAAQApApAA{A AffAA\)AzARAffAHA(AGAQAAzAARA\)AÅA A33A AA(AHA33ARA33A{A(A\A{AA\A{AGAA =A AGAA=qA{AzAyAA\ARAAzAAAAAAffA=qAAWAmApAVRAw =AApApA AAAHAAGAA{AAzA(AAAAAzAA =A33AA߮A߮AAzAffA\AB\)B B pBzBAGBA\)AB33B!B@(BEBL=qAA33AAۙAAApAA؏\A{AAffAθRAAA =AAAAAAAA{BAAffBffB33B,GB(GAA=qARA\)A(AAQAApAGAGAQA33AAAA{AA=qAAApA33A\A(A BGB\)AAQApA A =A\)AGAAAAᙚA =AA33AA AA{A=qAׅABGBBBffB (B;\)BJBD AAA{ApAAApA AAA=qAȏ\AУADžAAAA\AAA\AA\)AGA =AAQA =ARA33AARAzAHAHA\A{AffAA33A A\)AffAzA\)AAAAffAA(AA{33AuA{AuGAQAAuAk\)AxQAA=qAzA33AffA =A\AGAHAA AA\)AARAA\)AQAAApA AAzA =AzAAApAvRAF=qAgA =AәARAA=qAA£ApBQB pBQB(BB HBBffBffBB zBB'B*ffB(B!QB$B(B(33B)pB)B)B&B%B,ffB0 =B,pB$BB\)BB BB$\BB =BGBBB\)BBBHBRA =A噚AAHAHA B&pB,B. =B-B0GB>zBQ =B[BUB/33B-\)B,\)B*33B.B733BB(BFQB@B(B%33B#RB%{B%zB&B&pB&B+(B$ =B(B$BBB ffB$BB{AAAApAHA(BB$QB#RB%QB#B"B!RBB B$\B B%B$B$B!\)B"B" B"B#{B$33B)ffB (B!GB!ffB"(B"zB GB BB\)B{BB =BBBB B! B,GB1(B*33B{BBBB{B HB pB B\)BffB =qB{BB33BB B\BBBffB(B (B zBffB!ffB6zB<B6RB =B =BB{BB B33BBffAHA AA A\)AAۙBGB AAB33B\)B6 B<BA{ARAAA\BBHB){B2\B/A\)AHA(AAAGA\AA33A(A33A AA AQAA=qAGA =AApA{AGA AffAA=qAAQAApA{AApA =AA33A(A=qA =AAAAAALAc A|AAGA{AᙚAGARAGApA AHA=qAӮAGAA\)BBBQBBRBB ffB5GB!zB)33B-(B.B0=qB/33B0zB0B2B.B-B-RB.B+B(B&33B, =B/{B* B* B)\)B-ffB( B'HB$B$B&(B BBHBzBB'ffB,B1BBBGBHBB-BE=qBGBOB BA =BBARA{AffAAA33B BpAҸRAzA{AffAAARA{AA AHAQAAģAzA߮AAA =AAAA(AxAmAAQAyGAn=qAtAxA~{AxAj{Ac A{ =AfffA\(AG ATA\ATQAMAR{A`APAMpA?\)AS\)ABHAUA4zA@QA=AIAFRA`AC A@QAC33ANRA<(A:{A?A>HA:HAFHALA6HAMADA1A0(A&=qA8A1pA(A1ABRA%A,(AF{AMGAHAS =AOAo =AA\)AyGAFRAPAZ=qAn{AAAFHAK\)A.RAO =AJ\AFRADzAXA>{AO\)AO\)AIGABffA[A_ =AwA\Ap(Ao =AzHAiGAAQAA(A=qAAA\)AAA =AzA\A(AGAlA =AzA{A~ffAA(AA33AqGArRAtQA =AAAGAAA\)AA\A\)A{AA(AHARAxARAA A33AGAdAR\AHA/ =AK33A[33AJ=qA7\)AV\AeAnRAaGAb\AZffAIGA\AmAo Ap(At(AbffAyGAhA AiGAqpAg\)AqAg AxA\)Af=qAo33AqpAhzAaAAGAGApAaA_33AZ=qA\A`AffAAyAXAMAGAQA^\AOASA_\)AQGAIA`zAQpA[33ATQAdAPQAAA1A1AFffA9AC33A5A'ARA-A$zA:\A'A(A.HA((A@AGAAHA8zA7\)AEA=AZffAZ{ArffAAzA5GA,ApARA*=qA(A1A-GA((A4A,A A-A.=qA/ =A0A#Ac AA'A$zA-A =A A&\A=A,(@ȣ@A"HA;AEAR{A*\AATAo =AffAA\AAA =AAAffAQAffAQA33A\)A =ARA{A\)AAQAAARAAAA=qAQB=qB BAA{A33AQAAARAAAAA =AA\)AffA33AA\)AAA33AAHAHA Aw =Ax(AfRAs AAffAO33AiGAiA`zAYGAmAANffA8AG\)A# =AB{AABffA/\)AA pA3 =AD(AG\)AB=qAMpAMGAMGA;AffApAyA}A33AqpARA\A33A33AAAHAAAAAAAA33ARAAAvHAtzAuAk\)A`Av\A9AsAzAAGAAzA AA{\)ArHAw =AhAdAk AGA\AAiGAZ{AMGAXQAUAVHAIAJRAC\)A4ADzAL(AN=qA)pA\A5A4(A/ =A)A-A>ffAS\)A2RATA,A(A1pA)A&HApA#AAA&{A-A:HA+\)A+ =A$A/A4A5GA3A4(A2{A/\)AC =AK =AHQAFffAffA.ffA4(A8AA/\)AzA5GA-pA3 =AJ{AEAK A]AL(A@AzAAAQAAA6HA.HA%pA=A;33A A/ =A{A A^{A2HA=A5A#A?\)A; A(A:{A<(A:ffA9A.HA>=qA6\A>HALABRAA3 A$A7A,(A.RA+\)A9GA# A/ A)A=pA? A; A*\A.ffA\)A&{ARA,A%A&\A*ffA:RAAA((A QA\ACAZRA9pAEpACA8AAAnRA'A@(AEpAffA;A=GA?\)ABHAK A.HA7AB\A>HAVRA,A]pAZ{A9GADAJ=qAC33A>{AMASA\A\AABHAMAL(AV=qAHAdQAeA"RABffA=AIA\QAA@ffAN=qAR{AQALALARRAN\AeA>{AO33AYAhzAN\ACA=A?A1GAGA1pAhA=A=AG33ADA7\)A AG =ADALQAPAEAKAMA^HAVffAw33AMAjRAMAPADALAC\)A`AK\)A5AHAQA?APA4ApA>{A? ADA@ALA =A^=qAk A6ffA8(AEAJ\AB\AHQAFffAHA9AA\)AHAQAAAPAL(AGAP(ABffAUAfffApApA]AqGAO A{33AxAQA{ A{ApAzA AA =AA A =AGA33AhAvRAHA\)BRBB =AXAZ{AXzAW\)A[ ASAGAFffALAAVffAOA>\AUAGATQA=AiA@zA<(A>ffA? =A?33A8(A&=qA\A>HAC33A;ADQA>ffAcA.ffA5GA4A!A+\)A0AA Q@33A:{A-A5A4zA-GA7A>ffAN=qAQAK =Ak\)A2HA9A5A4(A(A.{ABRAOAg =AUAzA(A#A @\)A\A=qADA"=qA%pA'\)A%A/ A7 =A3 =A-A4(A1A,(A4QA4A5pA:RA)AA&=qA AA (A$(A!pARA%A/ AAA>ffA5AVffA|AAlQAPA=ADQA>{ABRAUAhzAALAdzAW A_33AlQAZRAMAR\AXAN=qAQAIGATA[Ao =A2HA+\)A4zAL(AjHA\Ac =At(AzHA[ =AtAbRAyAmAiGApAN\A`QAk AzRAyAdAgAzA^=qAG A}A\)AApA\)AA =AA{AA =AA(AHAGAHA{AAA\A AA =AAAA =ApAffApA(AA=qA(AAffA{A33A\AffA33AAAAAA33AffApApAffAzA AAA{AAAAAHAřAAAffARAApA\AA(A33AA33ApA\)AzA噚A{A(AAGAAAHAAHAAGA}GAqGAAAApAڏ\ABGAHAQAAAGAAGA=qARApAGA33A=qARAw =Ab=qAH(AAA\BQAAGAAB =qA33A{A=qBDHAϙBK(AGBHAB?ABCffAB6zA]B+\@=qB((AMB \)AA8A"{AAIA'Az{A'\)AA=A!A0ADQA-pAPAWAUGAk A=qAAtQA=qAhQA\AZ\AdAAC33AAAw\)AOAfffAAA(AC A A =AAQAzAA =AAA{AAHAA AHAHAHAz{AQA\)A(AAAA\A =AAAQA~=qA=qAQAAхAGAGA\A\)AAAzAAz{A{AffAAQA{AGAAAGAAřAffAAQAApBHAA\)ApBB(QABAAApAAQAA33B,33A=qARB8BzBAиRA݅A =AAAиRBpA(B\)AB=qABABXABB1BQB%B^HBB6AA=qApAB33B8B=GB;pB-B4HBmzB0RBzB.pB.=qB-BCGB8BRB6\BBB\)BMBS{BQBuBSBU{B1{BM\)BBQBJpB.Bc =BEBLB5B5B F1F2F3F4F5F6F7                  f f       f f f               f f          f f f f f f f f           f f f f f f     f      f f f f f     f f                f f     f f f f f f f f          f f f f f           f f f f f f       f f    f f                  f f f f f f f f f       f      f f f f f f f      f    f f f f f f            f f f        f f f f f         f f f f f               f f f f    f f f f f f      f f f f f         f f         f f f f f f               f f f f f f f f "binding site for residue na a 335ac1 F"binding site for residue na a 336  ac2F#binding site for residue mlt a 337 4ac30F#binding site for residue mlt a 337ac3F6@K4#@@?AA@@?AAA A@@?AAA A0A@@@?AAA @@@?AA@@?AAA A0A@@@?AAA0@@?AA@@?A@@?AA@@?AA@@?A@@?AAA A0A@A`ApA@@?AA@@?A@@?AA@@?AAA AP@@@?AAA A0A@@@?AA@@?AA@@?AAA A0A@A`ApA@@?AA@@?AAA @@@?AAA APA@@?AAA @@A@A`@@@?AAA AP@@?AAA @@A@A`@@@?AAA A@@?AAA @@@?AAA0@@?AA@@?AA@@?AAA A0A@@@?AA@@?AA@@?AA@@?AA@@?AAA AP@@@@?AA@@?AAA @@@?AAA @@@?AA@@?A@@?AAA APA@@?AAA A0A@@@?AAA0@@?AA@@?AAA @@@?AAA A0A@@@?AAA @@A@A`@@@?AAA AP@@?AAA AP@@@@?AAA A0A@@@?AAA APA@@?A@@?AAA0@@?AA@@?AAA AP@@@?AAA A0A@@@?AAA AP@@?AAA A0A@@@?AAA AP@@@@?AAA AP@@?AAA A@@?AA@@?AAA @@@?AAA0@@?AA@@?AAA AP@@@?AAA A0A@A`ApA@@?AA@@?AAA AP@@?A@@?AA@@?AAA @@@?AA@@?AA@@?AAA A0A@A`ApA@@?AAA A0A@@@?AA@@?AA@@?AA@@?AAA @@A@A`@@@?AAA AP@@@?AA@@?AA@@?AAA @@A@A`@@@?AAA @@@?AAA A0A@@@?AA@@?AAA AP@@?AAA AP@@@@?AAA A0A@A`ApA@@?AAA A0A@@@?AAA AP@@@?AA@@?A@@?AA@@?AA@@?AA@@?AAA A0A@A`ApA@@?AAA @@@?AAA A0A@@@?AA@@?A@@?AA@@?AAA A0A@A`ApA@@?AAA APA@@?AA@@?AAA @@@?AAA @@@?AA@@?AA@@?AAA A0A@A`ApA@@?AAA A0A@A`ApA@@?AAA AP@@@?AAA APA@@?AAA A0A@A`ApA@@?AAA A0A@A`ApA@@?A@@?AAA A0A@A`ApA@@?AA@@?AAA @@A@A`@@@?AAA AP@@@@?AAA A0A@A`ApA@@?AAA AP@@?AAA AP@@@?AAA A0A@@@?AAA A0A@@@?AAA AP@@@?AAA AP@@@@?AA@@?AA@@?AAA A0A@A`ApA@@?A@@?AAA A0A@@@?AA@@?AAA AP@@@?AAA A0A@ApAAAA@@@?AAA@@?A@@?AA@@?AAA APA@@?AAA A0A@@@?AAA APA@@?AAA AP@@@?AA@@?AAA @@@?AAA A0A@@@?AAA0@@?AA@@?AA@@?AAA AP@@?A@@?AA@@?AAA A0A@A`ApA@@?AAA AP@@?AA@@?AA@@?AA@@?AAA AP@@@@?AAA A0A@@@?AA@@?AAA A0A@@@?AAA APA@@?AAA AP@@?AAA A0A@@@?AAA0@@?AAA @@@?AA@@?AAA @@@?AAA A0A@@@?AAA A0A@@@?AAA @@@?AAA A0A@@@?AAA @@@?AAA AP@@@@?AAA A0A@ApAAAA@@?AAA AP@@?AA@@?AAA0@@?AAA @@@?AA@@?AA@@?AA@@?A@@?AA@@?AA@@?A@@?AA@@?A@@?AAA APA@@?AAA APA@@?AA@@?AA@@?AAA0@@?AA@@?AAA @@@?AA@@?AAA A0A@A`ApA@@?AA@@?AAA AP@@@?AA@@?AA@@?AAA A0A@@@?AAA AP@@@@?AAA AP@@?AAA A0A@A`ApA@@?A@@?AA@@?AAA A0A@A`ApA@@?AA@@?AAA @@A@A`@@@?AAA APA@@?AAA @@A@A`@@@?AAA AP@@@@?AAA AP@@?AAA AP@@@?AAA0@@?AA@@?AA@@?AAA @@A@A`@@@?AAA A0A@@@?A@@?AA@@?AAA @@@?AA@@?AAA0@@?AAA A0A@A`ApA@@?AA@@?AAA AP@@?AAA @@A@A`@@@?AAA A0A@@@?A@@?AAA @@@?AAA A0A@A`ApA@@?AAA AP@@?AAA APA@@?A@@?AAA0@@?AAA A0A@@@?AAA AP@@@?AA@@?AAA0@@?AA@@?AA@@?AAA APA@@?AAA A0A@@@?AAA APA@@?AA@@?A@@?AA@@?AA@@?AAA AP@@@@?AA@@?AAA AP@@@@?AA@@?AA@@?AAA AP@@@@?AA@@?AAA A0A@@@?AAA AP@@@@?AAA AP@@@@?AA@@?AAA A0A@A`ApA@@?AA@@?AAA @@A@A`@@@?AAA APA@@?AAA AP@@?AAA A0A@@@?AA@@?AAA APA@@@?AAAA A A0A0A@A@@@?AAA A0A@A`ApA@@?AAA @@@?AAA APA@@?A@@?AA@@?AAA AP@@?AA@@?AAA A0A@@@?AAA APA@@?AAA @@@?AA@@?AA@@?A@@?AAA A0A@@@?AAA AP@@?AAA A0A@A`ApA@@?AA@@?AAA @@@?AAA0@@?A@@?AAA A0A@A`ApA@@?AA@@?AA@@?AAA AP@@@@?A@@?AAA AP@@@?AAA @@A@A`@@@?AAA A0A@@@?AAA0@@?AAA0@@?AA@@?AA@@?AA@@?AAA AP@@@?AAA @@@?AAA @@@?AAA A0A@@@?AAA A0A@@@?AAA APA@@?A@@?AA@@?AA@@?AA@@?AAA AP@@@@?AA@@?AA@@?AAA AP@@@@?AA@@?AA@@?AAA @@@?AAA0@@?AAA APA@@?AAA A0A@A`ApA@@?A@@?AAA A0A@A`ApA@@?AA@@?AAA AP@@@?AA@@@?AAAA A APAP@@@@@@?AA@@?AAA A0A@@@?AAA0TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\\\\\\\\\TTTTTTTTTTTTTTTTTTTTT\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\TTTTTTTTTTTTT\\\\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\\\\\TTTTT\\\\\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT3DR3 h a a a a a a 1 1 1 1 1 1 1 1 1 1 1 1 1 1 a a a a a a a a a 2 2 2 2 2 2 3 3 3 3 a a a a 4 4 4 4 4 a a a a 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 a a a a 6 6 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 a a 8 8 8 8 8 8 a a a 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 b b b b b b 10 10 10 10 10 11 11 11 11 11 b b b 12 12 12 12 12 12 12 12 12 12 12 b b b b b b b b b b b b b b b 13 13 13 13 13 13 13 13 13 13 13 13 13 13 b b b 14 14 14 14 14 b b b b b b b b b b b b b b b b 15 15 15 15 15 15 15 15 15 15 15 15 15 150K;2ך@n-acetyl-gamma-glutamyl-phosphate reductase; chain: a; synonym: agpr, n-acetyl-glutamate semialdehyde dehydrogenase, nagsa dehydrogenase; ec: 1.2.1.38; engineered: yes3DR3B13dr3 P 62 2 2 BBB??@ a???@MS"`B@Ye^ s??z?z?C>FIm?z@MS"`Bz@Ye^ sC>FIm???@MS"`B@Ye^ s?????z?z?C>FIm  `AMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAMMHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW `\aa ff fffff ffffffffffffff ffffff ffff fffffffffffff ffffffff fffffffffff fffffffff fffffffff fffff fffffffff fffffffffff ff ffffffffffffffaana' aana2'aamltj