I3.6-1h /data/swissprot/ 3F4N.pdbdupa 1M5W.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of Pyridoxal Phosphate Biosynthetic Protein Pdxj From Yersinia Pestis[/h3] [p]Y.Kim, N.Maltseva, J.Stam, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3F4N" target="blank"]3F4N[/a] [small](deposited on 01-NOV-08)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1M5W.pdb3F4N a_3F4NB1  1M5W3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F 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AAAAAAAAHHHHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW 2<aaGfff fffffffff ffffffffff ff ffffffffffff fffff fff ffffffff BfJbbDfff fffffffff ffffffffff ffBff ffffffffffffff fffff ffff ffffffff fcc?%fffff fffffffff ffffffffff ffff fffffffffffff ffff fff ffffffffff ff9dd;fff fffffffff fffffffffff ffff ffffffffffffffff ffBfff fBff ffffffff ?seeB:ff fffffffff ffffffffffU ff fffffffffffffffff ffff fff ffffffffff ffff0fff fffffffff fffffffffff ffff fffffffffffffff fffff ffff fffffffff fgg1fff ffffffffff fffffffffff fff ffffffffffff fffff fff fffffffff fhh=ff fffffffff ffffffffff ffcf ffffffffffff fffff fff fffffffff faapxpD dex=i_poXpxppyridoxine-5'-phosphatebbpxpD Xpxppyridoxine-5'-phosphateccpxpD Xpxppyridoxine-5'-phosphateccso4sddpxpD Xpxppyridoxine-5'-phosphateeepxpD Xpxppyridoxine-5'-phosphateeeso4sUeeso42sffpxpD Xpxppyridoxine-5'-phosphateggpxpD Xpxppyridoxine-5'-phosphatehhpxpD 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_ala  _asp   _leu  Eleu Eleu!% "!#$""& Egly&%')&('* Eval'*)+-0*,+*./--1  Easn+1024813215467559  _ile298:<@9;:9=><?<=A  Hasp:A@BDHACBAEDFGEEI  Hhis BIHJLRIKJIMLNOMPMQNQOPS  HileJSRTVZSUTSWXVYVW[ Hala T[Z\^_[]\[` Hthr\`_acf`ba`deccg Hleuagfhjngihgkjlmkko Harg honpryoqposrtsutvuwxvvz Hasnpzy{}z|{z~}~~ _ala { _arg  _gly _thr _ile _tyr  _pro _asp Hpro Hval Hgln  Hala  Hala  Hphe ! 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"#!!%e Bval%$&(+%'&%)*((,f _thr&,+-/2,.-,01//3g _thr-3246935437866:h _glu 4:9;=B:<;:>=?>@A??Ci _gly;CBDFCEDGj _glyDGFHJGIHKk BleuHKJLNRKMLKONPQOOSl _aspLSRTVZSUTSWVXYWW[m _valT[Z\^a[]\[_`^^bn Gala \bacefbdcbgo Gglycgfhjgihkp Ggln hkjlnskmlkonpoqrpptq Hvalltsuwztvutxyww{r Haspu{z|~{}|{~s Hlys |t Hmetu Hthrv Hleuw Hala x Hvaly Hglyz Harg { Hleu| Hala } Gasp~ Gval _gly _ile Eleu Eval Eser  Eleu Ephe           Eile  _asp _ala !" # _asp#"$&*#%$#'&()''+ Hphe $+*,.5+-,+/.01/2/30414236 Harg ,6579@6876:9;:<;=<>?==A Hgln 7A@BDIACBAEDFEGHFFJ HileBJIKMQJLKJNOMPMNR HaspKRQSUYRTSRVUWXVVZ Hala SZY[]^Z\[Z_ Hala [_^`bc_a`_d Hval`dcegjdfedhiggk Hala ekjlnokmlkp _ala lpoqstprqpu _glyqutvxuwvy _ala vyxz|}y{zy~ _proz~}~~} Etyr  Eile Eglu  Eile Ehis  _thr Hgly Hala  Htyr  Hala  Hasp _ala  _ser  _thr Hval Hleu Hglu  Harg           Hgln  Hala   Hglu  !#( "! $#%$&'%%) Hleu!)(*,0)+*)-,./--1 Hmet*1024813215465769 Harg 298:<C9;:9=<>=?>@?AB@@D Hile:DCEGKDFEDHIGJGHL Hala ELKMOPLNMLQ Hlys MQPRTYQSRQUTVUWVXWZ Hala RZY[]^Z\[Z_ Hala [_^`bc_a`_d Hthr`dcegjdfedhiggk Htyr ekjlnvkmlkonpqorosptqtrsutw Hala lwvxz{wyxw| Hala x|{}|~}| Hgly} _lys  _gly _leu Elys  Eval Easn Eala  Egly _his  _gly _leu _thr _tyr  _his  _asn Hval Hgln  Hpro         Hile     Hala  Hala  _leu "&! #"$%##' _pro ',&(*-')('+*,&+. _glu (.-/16.0/.213245337 Bmet/768:>7987;:<;=<? _his 8?>@BH?A@?CBDECFCGDGEFI Eglu @IHJLQIKJIMLNMOPNNR EleuJRQSUYRTSRVUWXVVZ EasnSZY[]aZ\[Z^]_`^^b Eile[baceibdcbfgehefj _glycjikmjlkn Hhis knmoqwnponrqstrurvsvtux Hala oxwy{|xzyx} Hiley}|~}~} Hile~ Hgly Hgln  Hala  Hval Hmet Hthr _gly Hleu Hala  Hala  Hala  Hval Hthr Hasp Hmet Hlys  Hval Hleu Hmet         _arg, ##! "$ Gglu $#%',$&%$(')(*+))- Gala %-,.01-/.-2 Garg .2135<243265768798:;99= _arg 3=<>@=?>=A@BACBDCEFDDH _ala HGIKLHJIHM _aspIMLNPTMONMQPRSQQU _leuNUTVX\UWVUYXZ[YY] EleuV]\^`d]_^]a`bcaae Eleu^edfhlegfeihjkiim Eglyfmlnpmonq Evalnqprtwqsrquvttx  Easnrxwy{xzyx|{}~||  _iley  Hasp  Hhis   Hile Hala  Hthr Hleu Harg  Hasn _ala  _arg  _gly _thr _ile _tyr  _pro _asp Hpro         Hval  Hgln  Hala !" # Hala #"$&'#%$#(  Hphe $(')+2(*)(,+-.,/,0-1.1/03! Hile)3246:3543786967;" Hala 4;:<>?;=<;@# Hglu <@?ACH@BA@DCEDFGEEI$ Hgln AIHJLQIKJIMLNMOPNNR% Hala JRQSUVRTSRW& _glySWVXZWYX[' _ala X[Z\^_[]\[`( _asp\`_acg`ba`dcefddh) Eglyahgikhjil* Eileilkmoslnmlpqoropt+ Ethrmtsuwztvutxyww{, Evalu{z|~{}|{~~- Ehis |. _leu/ _arg 0 _glu 1 _asp2 _arg 3 _arg 4 _his 5 _ile6 _thr7 Hasp8 Harg 9 Hasp: Hval  ; Harg                   < Hile           = Hleu                > Harg       &      ! " ! # " $ % # # '? Hgln   ' & ( * / ' ) ( ' + * , + - . , , 0@ Hthr ( 0 / 1 3 6 0 2 1 0 4 5 3 3 7A _ile 1 7 6 8 : > 7 9 8 7 ; < : = : ; ?B _gln  8 ? > @ B G ? A @ ? C B D C E F D D HC _thr @ H G I K N O H J I H L M K K QD _arg, I P I Q N R V O S W d P T d Q U R S P X Q Y V Z W [ X \ Y ] Z ^ [ _ \ ` b ] a c ^ _ ^ _ eE Emet R S e d f h l e g f e i h j i k j mF Easn f m l n p t m o n m q p r s q q uG Eleu n u t v x | u w v u y x z { y y }H Eglu  v } | ~ }  ~ }  I Emet ~  J _ala  K _val  L _thr  M Hasp  N Hglu   O Hmet  P Hval  Q Hasp  R Hile  S Hala  T Hcys  U Hasp  V Hile  W _lys   X _pro      Y _his               Z Ephe                         [ Ecys             \ Ecys    " $  !  # " %] Eleu % $ & ( , % ' & % ) ( * + ) ) -^ _val & - , . 0 3 - / . - 1 2 0 0 4_ _pro . 4 9 3 5 7 : 4 6 5 4 8 7 9 3 8 ;` _glu  5 ; : < > C ; = < ; ? > @ ? A B @ @ Da _lys  < D C E G L D F E D H G I H J I K J Mb _arg  E M L N P W M O N M Q P R Q S R T S U V T T Xc _gln  N X W Y [ ` X Z Y X \ [ ] \ ^ _ ] ] ad _glu  Y a ` b d a c b a e d f e g h f f ji _gly j i k m j l k nj _gly k n m o q n p o rk _leu o r q s u y r t s r v u w x v v zl _asp s z y { } z | { z ~ }  ~ ~ m _val {  n Gala  o Ggly  p Ggln   q Hval  r Hasp  s Hlys   t Hmet  u Hthr  v Hleu  w Hala  x Hval  y Hgly  z Harg   { Hleu  | Hala  } Gasp  ~ Gval   _gly        _ile              Eleu              Eval                Eser      !      " Eleu  " ! # % ) " $ # " & % ' ( & & * Ephe  # * ) + - 4 * , + * . - / 0 . 1 . 2 / 3 0 3 1 2 5 Eile + 5 4 6 8 < 5 7 6 5 9 : 8 ; 8 9 = _asp 6 = < > @ D = ? > = A @ B C A A E _ala > E D F H I E G F E J _asp F J I K M Q J L K J N M O P N N R Hphe  K R Q S U \ R T S R V U W X V Y V Z W [ X [ Y Z ] Harg  S ] \ ^ ` g ] _ ^ ] a ` b a c b d c e f d d h Hgln  ^ h g i k p h j i h l k m l n o m m q Hile i q p r t x q s r q u v t w t u y Hasp r y x z | y { z y } | ~  } }  Hala z   Hala   Hval   Hala   _ala   _gly   _ala   _pro   Etyr    Eile   Eglu    Eile   Ehis    _thr   Hgly   Hala   Htyr    Hala   Hasp      _ala           _ser      _thr               Hval                Hleu     $     ! " # ! ! % Hglu   % $ & ( - % ' & % ) ( * ) + , * * . Harg  & . - / 1 8 . 0 / . 2 1 3 2 4 3 5 4 6 7 5 5 9 Hgln  / 9 8 : < A 9 ; : 9 = < > = ? @ > > B Hala : B A C E F B D C B G Hglu  C G F H J O G I H G K J L K M N L L P Hleu H P O Q S W P R Q P T S U V T T X Hmet Q X W Y [ _ X Z Y X \ [ ] \ ^ ] ` Harg  Y ` _ a c j ` b a ` d c e d f e g f h i g g k Hile a k j l n r k m l k o p n q n o s Hala l s r t v w s u t s x Hlys  t x w y { x z y x | { } | ~ }  ~  Hala y   Hala   Hthr   Htyr    Hala   Hala   Hgly   Glys    _gly   _leu   Elys    Eval   Easn   Eala   Egly   _his    _gly   _leu   _thr   _tyr                    _his                 _asn                 Hval     #     ! "  $ Hgln   $ # % ' , $ & % $ ( ' ) ( * + ) ) - Hpro % - 2 , . 0 3 - / . - 1 0 2 , 1 4 Hile . 4 3 5 7 ; 4 6 5 4 8 9 7 : 7 8 < Hala 5 < ; = ? @ < > = < A Hala = A @ B D E A C B A F _leu B F E G I M F H G F J I K L J J N _pro G N S M O Q T N P O N R Q S M R U _glu  O U T V X ] U W V U Y X Z Y [ \ Z Z ^ Bmet V ^ ] _ a e ^ ` _ ^ b a c b d c f _his  _ f e g i o f h g f j i k l j m j n k n l m p Eglu  g p o q s x p r q p t s u t v w u u y Eleu q y x z | y { z y } | ~  } }  Easn z   Eile   _gly   Hhis    Hala   Hile   Hile   Hgly   Hgln    Hala   Hval   Hmet   Hthr   _gly   Hleu   Hala   Hala   Hala   Hval   Hthr    Hasp         Hmet     Hlys  Hval!$ "#!!% Hleu%$&(,%'&%)(*+))- Hmet&-,.04-/.-1021325 Harg .5468?576598:9;:<;=><<@ Hglu 6@?ACH@BA@DCEDFGEEI Hala AIHJLMIKJIN Garg JNMOQXNPONRQSRTSUTVWUUY _arg OYXZ\Y[ZY]\^]_^`_ab``d _ala dceghdfedi _meteihjlpikjimlnmonq _ala jqprtuqsrqv _asprvuwy}vxwvzy{|zz~ _leuw~}~~ Eleu Eleu Egly Eval  Easn  _ile  Hasp  Hhis   Hile Hala  Hthr Hleu Harg  Hasn _ala  _arg  _gly _thr        _ile     _tyr  ! _pro!& "$'!#"!%$& %( _asp"(')+/(*)(,+-.,,0 Hpro)05/1360210435/47 Hval1768:=7987;<::> Hgln 8>=?AF>@?>BACBDECCG Hala ?GFHJKGIHGL Hala HLKMOPLNMLQ  Hphe MQPRT[QSRQUTVWUXUYVZWZXY\! HileR\[]_c\^]\`a_b_`d" Hala ]dceghdfedi# Hglu eihjlqikjimlnmopnnr$ Hgln jrqsuzrtsrvuwvxyww{% Hala s{z|~{}|{& _gly|' _ala ( _asp) Egly* Eile+ Ethr, Eval- Ehis . Eleu/ _arg,0 _glu 1 _asp2 _arg 3 _arg 4 _his 5 Bile    6 _thr      7 Hasp 8 Harg % ! "!#$""&9 Hasp&%')-&('&*)+,**.: Hval'.-/14.0/.23115; Harg /5468?576598:9;:<;=><<@< Hile6@?ACG@BA@DECFCDH= HleuAHGIKOHJIHLKMNLLP> Harg IPOQSZPRQPTSUTVUWVXYWW[? Hgln Q[Z\^c[]\[_^`_ab``d@ Hthr\dcegjdfedhiggkA _ileekjlnrkmlkopnqnosB _gln lsrtv{sutswvxwyzxx|C _thrt|{}|~}|D _arg }E EmetF EasnG EleuH Eglu I EmetJ _ala K _valL _thrM HaspN Hglu O HmetP HvalQ HaspR HileS Hala T Hcys U Hasp       V Hile    W _lys X _pro#!$ "!#"%Y _his %$&(.%'&%)(*+),)-*-+,/Z Ephe &/.029/10/32453637485867:[ Ecys 0:9;=?:<;:>=@\ Ecys ;@?ACE@BA@DCF] EleuAFEGIMFHGFJIKLJJN^ _valGNMOQTNPONRSQQU_ _proOUZTVX[UWVUYXZTY\` _glu V\[]_d\^]\`_a`bcaaea _lys ]edfhmegfeihjikjlknb _arg fnmoqxnponrqsrtsutvwuuyc _gln oyxz|y{zy}|~}~~d _glu ze Bvalf _thrg _thrh _glu i _glyj _glyk Bleul _aspm _valn Gala o Gglyp Ggln q Hvalr Hasps Hlys t Hmetu Hthrv Hleu w Hala         x Hval  y Hglyz Harg # !"  ${ Hleu$#%'+$&%$(')*((,| Hala %,+-/0,.-,1} Gasp-1024813215467559~ Gval298:<?9;:9=><<@ _gly:@?AC@BAD _ileADCEGKDFEDHIGJGHL EleuELKMOSLNMLPOQRPPT EvalMTSUWZTVUTXYWW[ Eser U[Z\^`[]\[_^a Eleu\a`bdhacbaedfgeei Ephe bihjlsikjimlnompmqnrorpqt Eilejtsuw{tvutxywzwx| _aspu|{}|~}| _ala } _asp Hphe  Harg  Hgln  Hile Hasp Hala  Hala  Hval Hala  Hala  _gly _ala  _pro Etyr  Eile Eglu  Eile          Ehis   _thr ! Hgly! "$!#"% Hala "%$&()%'&%* Htyr &*)+-5*,+*.-/0.1.2/30312436 Hala +6579:6876; Hasp7;:<>B;=<;?>@A??C _ala <CBDFGCEDCH _ser DHGIKMHJIHLKN _thrINMOQTNPONRSQQU HvalOUTVX[UWVUYZXX\ HleuV\[]_c\^]\`_ab``d Hglu ]dcegldfedhgihjkiim Harg emlnpwmonmqprqsrtsuvttx Hgln nxwy{xzyx|{}|~}} Hala y Hglu  Hleu Hmet Harg  Hile Hala  Hlys  Hala  Hala  Hthr Htyr  Hala  Hala  Hgly Glys  _gly _leu Elys   Eval           Easn  Eala  Egly ! _his ! "$*!#"!%$&'%(%)&)'(+ _gly"+*,.+-,/ _leu,/.026/10/3245337 _thr0768:=7987;<::> _tyr 8>=?AI>@?>BACDBEBFCGDGEFHGJ _his ?JIKMSJLKJNMOPNQNRORPQT _asnKTSUW[TVUTXWYZXX\ _valU\[]_b\^]\`a__c Hgln ]cbdfkcedcgfhgijhhl Hprodlqkmorlnmlpoqkps Hilemsrtvzsutswxvyvw{ Hala t{z|~{}|{ _ala | _leu _pro _glu  Bmet _his  Eglu  Eleu Easn Eile _gly Hhis  Hala  Hile Hile Hgly Hgln  Hala  Hval     Hmet       Hthr  _gly Hleu "&! #"$%##' Hala  '&(*+')(', Hala (,+-/0,.-,1 Hala -1024513216 Hval26579<6876:;99= Hthr7=<>@C=?>=AB@@D Hasp>DCEGKDFEDHGIJHHL HmetELKMOSLNMLPOQPRQT Hlys MTSUW\TVUTXWYXZY[Z] HvalU]\^`c]_^]ab``d Hleu^dcegkdfedhgijhhl Hmetelkmoslnmlpoqprqt Harg mtsuw~tvutxwyxzy{z|}{{ Hglu u~ Gala  Garg  _arg  _ala  _asp _leu Eleu Eleu Egly Eval  Easn  _ile  Hasp  Hhis   Hile Hala  Hthr  Hleu            Harg   Hasn# !"  $ Hala $#%'($&%$) _arg %)(*,3)+*)-,.-/.0/12004 _gly*43574658 _thr5879;>8:98<=;;? _ile9?>@BF?A@?CDBEBCG _tyr @GFHJRGIHGKJLMKNKOLPMPNOQPS _proHSXRTVYSUTSWVXRWZ _aspTZY[]aZ\[Z^]_`^^b Hpro[bgacehbdcbfegafi Hvalcihjloikjimnllp Hgln jpoqsxprqptsutvwuuy Hala qyxz|}y{zy~ Hala z~}~~  Hphe ! Hile" Hala # Hglu $ Hgln % Gala & _gly' _ala ( _asp) Egly* Eile+ Ethr, Eval- Ehis . _leu/ _arg 0 _glu 1 _asp   2 _arg        3 _arg   !4 _his ! "$*!#"!%$&'%(%)&)'(+5 _ile"+*,.2+-,+/0.1./36 _thr,3246935437866:7 Hasp4:9;=A:<;:>=?@>>B8 Harg ;BACELBDCBFEGFHGIHJKIIM9 HaspCMLNPTMONMQPRSQQU: HvalNUTVX[UWVUYZXX\; Harg V\[]_f\^]\`_a`bacbdeccg< Hile]gfhjngihgkljmjko= Hleuhonprvoqposrtussw> Harg pwvxzwyxw{z|{}|~}~~? Hgln x@ HthrA _ileB _gln C _thrD _arg E EmetF EasnG EleuH Eglu I EmetJ _ala K _valL _thrM HaspN Hglu O Hmet  P Hval          Q Hasp R Hile !S Hala ! "$%!#"!&T Hcys "&%')+&('&*),U Hasp',+-/3,.-,0/12004V Hile-4357;4654897:78<W _lys 5<;=?D<>=<@?A@BACBEX _pro=EJDFHKEGFEIHJDILY _his FLKMOULNMLPOQRPSPTQTRSVZ Ephe MVUWY`VXWVZY[\Z]Z^[_\_]^a[ Ecys Wa`bdfacbaedg\ Ecys bgfhjlgihgkjm] Eleuhmlnptmonmqprsqqu^ _valnutvx{uwvuyzxx|_ _prov|{}|~}|{` _glu }a _lys b Garg c Ggln d Gglu e Bvalf _thrg _thrh _glu i _glyj _glyk Bleul _aspm _valn _ala o _glyp _gln q Hvalr Hasp         s Hlys  t Hmet !u Hthr! "$'!#"!%&$$(v Hleu"(')+/(*)(,+-.,,0w Hala )0/13402105x Hval15468;57659:88<y Hgly6<;=?<>=@z Harg =@?ACJ@BA@DCEDFEGFHIGGK{ HleuAKJLNRKMLKONPQOOS| Hala LSRTVWSUTSX} GaspTXWY[_XZYX\[]^\\`~ GvalY`_acf`ba`deccg _glyagfhjgihk _ilehkjlnrkmlkopnqnos Eleulsrtvzsutswvxyww{ Evalt{z|~{}|{~~ Eser | Eleu Ephe  Eile _asp _ala  _asp Hphe  Harg, Hgln  Hile Hasp Hala  Hala  Hval Hala  _ala        _gly     _ala  _pro Etyr  (! "#!$!%"&#&$%'&) Eile)(*,0)+*)-.,/,-1 Eglu *10249132154657866: Eile2:9;=A:<;:>?=@=>B Ehis ;BACEKBDCBFEGHFIFJGJHIL _thrCLKMORLNMLPQOOS HglyMSRTVSUTW Hala TWVXZ[WYXW\ Htyr X\[]_g\^]\`_ab`c`daebecdfeh Hala ]hgiklhjihm Haspimlnptmonmqprsqqu _ala nutvxyuwvuz _ser vzy{}z|{z~} _thr{ Hval Hleu Hglu  Harg  Hgln$ Hala  Hglu  Hleu Hmet Harg  Hile Hala  Hlys  Hala  Hala  Hthr     Htyr        Hala   Hala  !" Hgly"!#%"$#& _lys #&%').&('&*)+*,+-,/ _gly'/.02/103 _leu03246:3543768977; Elys 4;:<>C;=<;?>@?A@BAD Eval<DCEGJDFEDHIGGK EasnEKJLNRKMLKONPQOOS Eala LSRTVWSUTSX EglyTXWY[XZY\ _his Y\[]_e\^]\`_ab`c`dadbcf _gly]fegifhgj _leugjikmqjlkjnmopnnr _thrkrqsuxrtsrvwuuy _tyr syxz|y{zy}|~}}~ _his z _asn Hval Hgln  Hpro Hile Hala  Hala  _leu _pro _glu  Bmet _his  Eglu  Eleu Easn Eile    _gly       Hhis   Hala  Hile!% "#!$!"& Hile&%')-&('&*+),)*. Hgly'.-/1.0/2 Hgln /2135:243265768977; Hala 3;:<>?;=<;@ Hval<@?ACF@BA@DECCG HmetAGFHJNGIHGKJLKMLO HthrHONPRUOQPOSTRRV _glyPVUWYVXWZ HleuWZY[]aZ\[Z^]_`^^b Hala [bacefbdcbg Hala cgfhjkgihgl Hala hlkmoplnmlq Hvalmqprtwqsrquvttx Hthrrxwy{~xzyx|}{{ Haspy~ Hmet Hlys  Hval Hleu Hmet Harg  Hglu  Hala  Harg  _arg  _asp _leu Eleu Eleu Egly Eval  Easn             _ile   Hasp !  Hhis ! "$*!#"!%$&'%(%)&)'(+  Hile"+*,.2+-,+/0.1./3 Hala ,3246735438 Hthr4879;>8:98<=;;? Hleu9?>@BF?A@?CBDECCG Harg @GFHJQGIHGKJLKMLNMOPNNR HasnHRQSUYRTSRVUWXVVZ _ala SZY[]^Z\[Z_ _arg [_^`bi_a`_cbdcedfeghffj _gly`jikmjlkn _thrknmoqtnponrsqqu _ileoutvx|uwvuyzx{xy} _tyr v}|~}~} _pro~ _asp Hpro Hval Hgln  Hala  Hala   Hphe ! Hile" Hala # Hglu $ Hgln % _ala & _gly' _ala ( _asp) Egly* Eile+ Ethr    , Eval      - Ehis  . _leu $! "#!!%/ _arg %$&(/%'&%)(*)+*,+-.,,00 _glu &0/13802104354675591 _asp198:<@9;:9=<>?==A2 _arg :A@BDKACBAEDFEGFHGIJHHL3 _arg BLKMOVLNMLPOQPRQSRTUSSW4 _his MWVXZ`WYXW[Z\][^[_\_]^a5 _ileXa`bdhacbaefdgdei6 _thrbihjloikjimnllp7 Haspjpoqswprqptsuvttx8 Harg qxwy{xzyx|{}|~}~9 Haspy: Hval; Harg < Hile= Hleu> Harg ? Hgln @ HthrA _ileB _gln C _thrD _arg,E EmetF EasnG Eleu        H Eglu  I EmetJ _ala  "#! $K _val $#%'*$&%$()''+L _thr%+*,.1+-,+/0..2M Hasp,213592432657866:N Hglu 3:9;=B:<;:>=?>@A??CO Hmet;CBDFJCEDCGFHGIHKP HvalDKJLNQKMLKOPNNRQ HaspLRQSUYRTSRVUWXVVZR HileSZY[]aZ\[Z^_]`]^bS Hala [bacefbdcbgT Hcys cgfhjlgihgkjmU HasphmlnptmonmqprsqquV Hilenutvx|uwvuyzx{xy}W _lys v}|~}~}X _pro~Y _his,Z Ephe [ Ecys \ Ecys ] Eleu^ _val_ _pro` _glu a _lys b _arg c _gln d _glu e Bval     f _thr            g _thr        h _glu                   i _gly         j _gly    "  !  #k Bleu # " $ & * # % $ # ' & ( ) ' ' +l _asp $ + * , . 2 + - , + / . 0 1 / / 3m _val , 3 2 4 6 9 3 5 4 3 7 8 6 6 :n Gala 4 : 9 ; = > : < ; : ?o Ggly ; ? > @ B ? 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Hile!!"!!!#!%!)!"!$!#!"!&!'!%!(!%!&!* Hasp!#!*!)!+!-!1!*!,!+!*!.!-!/!0!.!.!2 Hala !+!2!1!3!5!6!2!4!3!2!7 Hala !3!7!6!8!:!;!7!9!8!7!< Hval!8!<!;!=!?!B!<!>!=!<!@!A!?!?!C Hala !=!C!B!D!F!G!C!E!D!C!H Hala !D!H!G!I!K!L!H!J!I!H!M _gly!I!M!L!N!P!M!O!N!Q _ala !N!Q!P!R!T!U!Q!S!R!Q!V _pro!R!V![!U!W!Y!\!V!X!W!V!Z!Y![!U!Z!] Etyr !W!]!\!^!`!h!]!_!^!]!a!`!b!c!a!d!a!e!b!f!c!f!d!e!g!f!i Eile!^!i!h!j!l!p!i!k!j!i!m!n!l!o!l!m!q Eglu !j!q!p!r!t!y!q!s!r!q!u!t!v!u!w!x!v!v!z Eile!r!z!y!{!}!!z!|!{!z!~!!}!!}!~! Ehis !{!!!!!!!!!!!!!!!!!!!!!! _thr!!!!!!!!!!!!!!! Hgly!!!!!!!!! Hala !!!!!!!!!!! Htyr !!!!!!!!!!!!!!!!!!!!!!!!!!! Hala !!!!!!!!!!! Hasp!!!!!!!!!!!!!!!!! _ala !!!!!!!!!!! _ser !!!!!!!!!!!!! _thr!!!!!!!!!!!!!!! Hval!!!!!!!!!!!!!!! Hleu!!!!!!!!!!!!!!!!! Hglu !!!!!!!!!!!!!!!!!!! Harg !!!!!!!!!!!!!!!!!!!!!!! Hgln !!!!!!!!!!!!!!!!!!! Hala !!!!!!!!!!! Hglu !!!!!"!!!!!!!!!!!!" Hleu!""""""""""""""""  Hmet"" "" " "" " " " " " "" """ Harg " """""""""""""""""""""" Hile""""""#""""" "!""""" "$ Hala ""$"#"%"'"("$"&"%"$") Hlys "%")"("*","1")"+"*")"-","."-"/"."0"/"2 Hala "*"2"1"3"5"6"2"4"3"2"7 Hala "3"7"6"8":";"7"9"8"7"< Hthr"8"<";"="?"B"<">"="<"@"A"?"?"C Htyr "="C"B"D"F"N"C"E"D"C"G"F"H"I"G"J"G"K"H"L"I"L"J"K"M"L"O Hala "D"O"N"P"R"S"O"Q"P"O"T Hala "P"T"S"U"W"X"T"V"U"T"Y Hgly"U"Y"X"Z"\"Y"["Z"] Glys "Z"]"\"^"`"e"]"_"^"]"a"`"b"a"c"b"d"c"f _gly"^"f"e"g"i"f"h"g"j _leu"g"j"i"k"m"q"j"l"k"j"n"m"o"p"n"n"r Elys "k"r"q"s"u"z"r"t"s"r"v"u"w"v"x"w"y"x"{ Eval"s"{"z"|"~""{"}"|"{"""~"~" Easn"|"""""""""""""""" Eala """"""""""" Egly""""""""" _his """"""""""""""""""""""" _gly""""""""" _leu""""""""""""""""" _thr""""""""""""""" _tyr """"""""""""""""""""""""""" _his """"""""""""""""""""""" _asn""""""""""""""""" _val""""""""""""""" Hgln """"""""""""""""""" Hpro""""""""""""""""" Hile""""""""""""""""" Hala """"""""""" _ala """"""""""" _leu""""""""""""""""" _pro""#"###"##"###"## _glu ##### ###### # # # # # # # # Bmet################# _his ###### #################! Eglu ##!# #"#$#)#!###"#!#%#$#&#%#'#(#&#&#* Eleu#"#*#)#+#-#1#*#,#+#*#.#-#/#0#.#.#2 Easn#+#2#1#3#5#9#2#4#3#2#6#5#7#8#6#6#: Eile#3#:#9#;#=#A#:#<#;#:#>#?#=#@#=#>#B _gly#;#B#A#C#E#B#D#C#F Hhis #C#F#E#G#I#O#F#H#G#F#J#I#K#L#J#M#J#N#K#N#L#M#P Hala #G#P#O#Q#S#T#P#R#Q#P#U Hile#Q#U#T#V#X#\#U#W#V#U#Y#Z#X#[#X#Y#] Hile#V#]#\#^#`#d#]#_#^#]#a#b#`#c#`#a#e Hgly#^#e#d#f#h#e#g#f#i Hgln #f#i#h#j#l#q#i#k#j#i#m#l#n#m#o#p#n#n#r Hala #j#r#q#s#u#v#r#t#s#r#w Hval#s#w#v#x#z#}#w#y#x#w#{#|#z#z#~ Hmet#x#~#}####~###~####### Hthr############### _gly######### Hleu################# Hala ########### Hala ########### Hala ########### Hval############### Hthr############### Hasp################# Hmet################# Hlys ################### Hval############### Hleu################# Hmet################## _arg,############################################# Gglu ######$####$#$$$$$$$ Gala #$$$$$ $$$$$  Garg $$ $ $ $ $$ $ $ $ $$ $$$$$$$$$$$ _arg $ $$$$$$$$$$$$$$$$$$$$$  _ala $ $$!$#$$$ $"$!$ $% _asp$!$%$$$&$($,$%$'$&$%$)$($*$+$)$)$- _leu$&$-$,$.$0$4$-$/$.$-$1$0$2$3$1$1$5 Eleu$.$5$4$6$8$<$5$7$6$5$9$8$:$;$9$9$= Eleu$6$=$<$>$@$D$=$?$>$=$A$@$B$C$A$A$E Egly$>$E$D$F$H$E$G$F$I Eval$F$I$H$J$L$O$I$K$J$I$M$N$L$L$P  Easn$J$P$O$Q$S$W$P$R$Q$P$T$S$U$V$T$T$X  _ile$Q$X$W$Y$[$_$X$Z$Y$X$\$]$[$^$[$\$`  Hasp$Y$`$_$a$c$g$`$b$a$`$d$c$e$f$d$d$h  Hhis $a$h$g$i$k$q$h$j$i$h$l$k$m$n$l$o$l$p$m$p$n$o$r  Hile$i$r$q$s$u$y$r$t$s$r$v$w$u$x$u$v$z Hala $s$z$y${$}$~$z$|${$z$ Hthr${$$~$$$$$$$$$$$$ Hleu$$$$$$$$$$$$$$$$$ Harg $$$$$$$$$$$$$$$$$$$$$$$ Hasn$$$$$$$$$$$$$$$$$ _ala $$$$$$$$$$$ _arg $$$$$$$$$$$$$$$$$$$$$$$ _gly$$$$$$$$$ _thr$$$$$$$$$$$$$$$ _ile$$$$$$$$$$$$$$$$$ _tyr $$$$$$$$$$$$$$$$$$$$$$$$$$$ _pro$$$$$$$$$$$$$$$$$ _asp$$$$$$$$$$$$$$$$$ Hpro$$$$$$$$$$$$$$$$$ Hval$$$$$$$$$$$$$$$ Hgln $$$$$$$$$$$$$$$$$$$ Hala $$$$$$$$$$$ Hala $$$$$$$$$$%  Hphe $%$%%% %%%%%%%%%%%%%% %% %%% ! Hile%% % % %%% % % % %%%%%%%" Hala % %%%%%%%%%%# Hglu %%%%%% %%%%%%%%%%%%%!$ Hgln %%!% %"%$%)%!%#%"%!%%%$%&%%%'%(%&%&%*% Gala %"%*%)%+%-%.%*%,%+%*%/& _gly%+%/%.%0%2%/%1%0%3' _ala %0%3%2%4%6%7%3%5%4%3%8( _asp%4%8%7%9%;%?%8%:%9%8%<%;%=%>%<%<%@) Egly%9%@%?%A%C%@%B%A%D* Eile%A%D%C%E%G%K%D%F%E%D%H%I%G%J%G%H%L+ Ethr%E%L%K%M%O%R%L%N%M%L%P%Q%O%O%S, Eval%M%S%R%T%V%Y%S%U%T%S%W%X%V%V%Z- Ehis %T%Z%Y%[%]%c%Z%\%[%Z%^%]%_%`%^%a%^%b%_%b%`%a%d. _leu%[%d%c%e%g%k%d%f%e%d%h%g%i%j%h%h%l/ _arg %e%l%k%m%o%v%l%n%m%l%p%o%q%p%r%q%s%r%t%u%s%s%w0 _glu %m%w%v%x%z%%w%y%x%w%{%z%|%{%}%~%|%|%1 _asp%x%%%%%%%%%%%%%%%%2 _arg %%%%%%%%%%%%%%%%%%%%%%%3 _arg %%%%%%%%%%%%%%%%%%%%%%%4 _his %%%%%%%%%%%%%%%%%%%%%%%5 _ile%%%%%%%%%%%%%%%%%6 _thr%%%%%%%%%%%%%%%7 Hasp%%%%%%%%%%%%%%%%%8 Harg %%%%%%%%%%%%%%%%%%%%%%%9 Hasp%%%%%%%%%%%%%%%%%: Hval%%%%%%%%%%%%%%%; Harg %%%%%%%%%%%%%%%%%%%%%%%< Hile%%%%%%%%%%%%%%%%%= Hleu%%%%%%%%%%%%%%%%%> Harg %%%%%%%%%%%%%%%%%%%%%%%? Hgln %%%&&&%&&%&&&&&&&&&@ Hthr&&&& & &&& & && & & & &A _ile& &&&&&&&&&&&&&&&&B _gln &&&&&&&&&&&&&&&&&&& C _thr&& &&!&#&&& &"&!& &$&%&#&#&'D _arg &!&'&&&(&*&1&'&)&(&'&+&*&,&+&-&,&.&-&/&0&.&.&2E Emet&(&2&1&3&5&9&2&4&3&2&6&5&7&6&8&7&:F Easn&3&:&9&;&=&A&:&<&;&:&>&=&?&@&>&>&BG Eleu&;&B&A&C&E&I&B&D&C&B&F&E&G&H&F&F&JH Eglu &C&J&I&K&M&R&J&L&K&J&N&M&O&N&P&Q&O&O&SI Emet&K&S&R&T&V&Z&S&U&T&S&W&V&X&W&Y&X&[J _ala &T&[&Z&\&^&_&[&]&\&[&`K _val&\&`&_&a&c&f&`&b&a&`&d&e&c&c&gL _thr&a&g&f&h&j&m&g&i&h&g&k&l&j&j&nM Hasp&h&n&m&o&q&u&n&p&o&n&r&q&s&t&r&r&vN Hglu &o&v&u&w&y&~&v&x&w&v&z&y&{&z&|&}&{&{&O Hmet&w&&~&&&&&&&&&&&&&&P Hval&&&&&&&&&&&&&&&Q Hasp&&&&&&&&&&&&&&&&&R Hile&&&&&&&&&&&&&&&&&S Hala &&&&&&&&&&&T Hcys &&&&&&&&&&&&&U Hasp&&&&&&&&&&&&&&&&&V Hile&&&&&&&&&&&&&&&&&W _lys &&&&&&&&&&&&&&&&&&&X _pro&&&&&&&&&&&&&&&&&Y _his &&&&&&&&&&&&&&&&&&&&&&&Z Ephe &&&&&&&&&&&&&&&&&&&&&&&&&[ Ecys &&&&&&&&&&&&&\ Ecys &&&&&&&&&&&&&] Eleu&&&&&&&&&&&&&&&&&^ _val&&&&&&&&&&&&&&&_ _pro&&&&&&&&&&&&&&&&'` _glu &'&'''''''''''''''' a _lys '' '' ' '' ' ' ' ' ' '' '''''b _arg ' ''''''''''''''''''''''c _gln ''''' '%'''''!' '"'!'#'$'"'"'&d _glu ''&'%''')'.'&'('''&'*')'+'*','-'+'+'/e Bval'''/'.'0'2'5'/'1'0'/'3'4'2'2'6f _thr'0'6'5'7'9'<'6'8'7'6':';'9'9'=g _thr'7'='<'>'@'C'D'='?'>'='A'B'@'@'Fh _glu$'>'E'>'F'C'G'K'D'H'L'U'E'I'U'F'J'G'H'E'M'F'N'K'O'L'P'M'Q'S'N'R'T'O'P'O'P'Vi _gly 'G'H'V'U'W'Y'V'X'W'Zj _gly'W'Z'Y'[']'Z'\'['^k Bleu'['^']'_'a'e'^'`'_'^'b'a'c'd'b'b'fl _asp'_'f'e'g'i'm'f'h'g'f'j'i'k'l'j'j'nm _val'g'n'm'o'q't'n'p'o'n'r's'q'q'un Gala 'o'u't'v'x'y'u'w'v'u'zo Ggly'v'z'y'{'}'z'|'{'~p Ggln '{'~'}''''~'''~'''''''''q Hval'''''''''''''''r Hasp'''''''''''''''''s Hlys '''''''''''''''''''t Hmet'''''''''''''''''u Hthr'''''''''''''''v Hleu'''''''''''''''''w Hala '''''''''''x Hval'''''''''''''''y Hgly'''''''''z Harg '''''''''''''''''''''''{ Hleu'''''''''''''''''| Hala '''''''''''} _asp'''''''''''''''''~ _val''''''''''''''' _gly''''''''' _ile''''''''''''''''' Eleu'''''(''''''''''( Eval'(((((((((((((( Eser (((( ( ( (( ( (( ( ( Eleu( (( (((((((((((((( Ephe (((((( (((((((((((((((((((! Eile((!( ("($(((!(#("(!(%(&($('($(%() _asp("()(((*(,(0()(+(*()(-(,(.(/(-(-(1 _ala (*(1(0(2(4(5(1(3(2(1(6 _asp(2(6(5(7(9(=(6(8(7(6(:(9(;(<(:(:(> Hphe (7(>(=(?(A(H(>(@(?(>(B(A(C(D(B(E(B(F(C(G(D(G(E(F(I Harg (?(I(H(J(L(S(I(K(J(I(M(L(N(M(O(N(P(O(Q(R(P(P(T Hgln (J(T(S(U(W(\(T(V(U(T(X(W(Y(X(Z([(Y(Y(] Hile(U(](\(^(`(d(](_(^(](a(b(`(c(`(a(e Hasp(^(e(d(f(h(l(e(g(f(e(i(h(j(k(i(i(m Hala (f(m(l(n(p(q(m(o(n(m(r Hala (n(r(q(s(u(v(r(t(s(r(w Hval(s(w(v(x(z(}(w(y(x(w({(|(z(z(~ Hala (x(~(}((((~(((~( _ala ((((((((((( _gly((((((((( _ala ((((((((((( _pro((((((((((((((((( Etyr ((((((((((((((((((((((((((( Eile((((((((((((((((( Eglu ((((((((((((((((((( Eile((((((((((((((((( Ehis ((((((((((((((((((((((( _thr((((((((((((((( Hgly((((((((( Hala ((((((((((( Htyr ((((((((((((((((((((((((((( Hala ((((((((((( _asp((((((((((((((((( _ala ((((((((((( _ser ((((((((((((( _thr((((()((((()(() Hval())))))))))))))  Hleu)) )) ) )) ) ) ) ) ) ))) ) ) Hglu ) )))))))))))))))))) Harg ))))))$))))))))) ))!) )")#)!)!)% Hgln ))%)$)&)()-)%)')&)%)))()*)))+),)*)*). Hala )&).)-)/)1)2).)0)/).)3 Hglu )/)3)2)4)6);)3)5)4)3)7)6)8)7)9):)8)8)< Hleu)4)<);)=)?)C)<)>)=)<)@)?)A)B)@)@)D Hmet)=)D)C)E)G)K)D)F)E)D)H)G)I)H)J)I)L Harg )E)L)K)M)O)V)L)N)M)L)P)O)Q)P)R)Q)S)R)T)U)S)S)W Hile)M)W)V)X)Z)^)W)Y)X)W)[)\)Z)])Z)[)_ Hala )X)_)^)`)b)c)_)a)`)_)d Hlys )`)d)c)e)g)l)d)f)e)d)h)g)i)h)j)i)k)j)m Hala )e)m)l)n)p)q)m)o)n)m)r Hala )n)r)q)s)u)v)r)t)s)r)w Hthr)s)w)v)x)z)})w)y)x)w){)|)z)z)~ Htyr )x)~)}))))~)))~))))))))))))))))) Hala ))))))))))) Hala ))))))))))) Hgly))))))))) Glys ))))))))))))))))))) _gly))))))))) _leu))))))))))))))))) Elys ))))))))))))))))))) Eval))))))))))))))) Easn))))))))))))))))) Eala ))))))))))) Egly))))))))) _his ))))))))))))))))))))))) _gly))))))))) _leu))))))))))))))))) _thr))))))))))))))) _tyr ))))))))))))))))))))))))))) _his )))))*))))))))))))))))* _asn)****************  Hval** ** * ** * * * * ** * * Hgln * ****************** Hpro*****************  Hile** **!*#*'* *"*!* *$*%*#*&*#*$*( Hala *!*(*'*)*+*,*(***)*(*- _ala *)*-*,*.*0*1*-*/*.*-*2 _leu*.*2*1*3*5*9*2*4*3*2*6*5*7*8*6*6*: _pro*3*:*?*9*;*=*@*:*<*;*:*>*=*?*9*>*A _glu *;*A*@*B*D*I*A*C*B*A*E*D*F*E*G*H*F*F*J Bmet*B*J*I*K*M*Q*J*L*K*J*N*M*O*N*P*O*R _his *K*R*Q*S*U*[*R*T*S*R*V*U*W*X*V*Y*V*Z*W*Z*X*Y*\ Eglu *S*\*[*]*_*d*\*^*]*\*`*_*a*`*b*c*a*a*e Eleu*]*e*d*f*h*l*e*g*f*e*i*h*j*k*i*i*m Easn*f*m*l*n*p*t*m*o*n*m*q*p*r*s*q*q*u Eile*n*u*t*v*x*|*u*w*v*u*y*z*x*{*x*y*} _gly*v*}*|*~**}**~* Hhis *~********************** Hala *********** Hile***************** Hile***************** Hgly********* Hgln ******************* Hala *********** Hval*************** Hmet***************** Hthr*************** _gly********* Hleu***************** Hala *********** Hala *********** Hala *********** Hval*************** Hthr*************** Hasp***************** Hmet*****+**********+ Hlys *+++++ +++++++++++++  Hval++ + + + ++ + + + +++ + + Hleu+ ++++++++++++++++ Hmet++++++ +++++++++++! Harg ++!+ +"+$+++!+#+"+!+%+$+&+%+'+&+(+'+)+*+(+(+, Hglu +"+,+++-+/+4+,+.+-+,+0+/+1+0+2+3+1+1+5 Hala +-+5+4+6+8+9+5+7+6+5+: Garg +6+:+9+;+=+D+:+<+;+:+>+=+?+>+@+?+A+@+B+C+A+A+E _arg +;+E+D+F+H+E+G+F+E+I+H+J+I+K+J+L+K+M+N+L+L+P _ala +P+O+Q+S+T+P+R+Q+P+U _asp+Q+U+T+V+X+\+U+W+V+U+Y+X+Z+[+Y+Y+] _leu+V+]+\+^+`+d+]+_+^+]+a+`+b+c+a+a+e Eleu+^+e+d+f+h+l+e+g+f+e+i+h+j+k+i+i+m Eleu+f+m+l+n+p+t+m+o+n+m+q+p+r+s+q+q+u Egly+n+u+t+v+x+u+w+v+y Eval+v+y+x+z+|++y+{+z+y+}+~+|+|+  Easn+z++++++++++++++++  _ile+++++++++++++++++  Hasp+++++++++++++++++  Hhis +++++++++++++++++++++++  Hile+++++++++++++++++ Hala +++++++++++ Hthr+++++++++++++++ Hleu+++++++++++++++++ Harg +++++++++++++++++++++++ Hasn+++++++++++++++++ _ala +++++++++++ _arg +++++++++++++++++++++++ _gly+++++++++ _thr+++++++++++++++ _ile+++++++++++++++++ _tyr ++++++++++++++++++++++++++, _pro+,,+,,,,,,,,,,+,, _asp,,,,, ,,, ,,, , , , , , , Hpro,,,,,,,,,,,,,,,,, Hval,,,,,,,,,,,,,,, Hgln ,,,,, ,%,,,,,!, ,",!,#,$,",",& Hala ,,&,%,',),*,&,(,',&,+ Hala ,',+,*,,,.,/,+,-,,,+,0  Hphe ,,,0,/,1,3,:,0,2,1,0,4,3,5,6,4,7,4,8,5,9,6,9,7,8,;! Hile,1,;,:,<,>,B,;,=,<,;,?,@,>,A,>,?,C" Hala ,<,C,B,D,F,G,C,E,D,C,H# Hglu ,D,H,G,I,K,P,H,J,I,H,L,K,M,L,N,O,M,M,Q$ Ggln ,I,Q,P,R,T,Y,Q,S,R,Q,U,T,V,U,W,X,V,V,Z% Gala ,R,Z,Y,[,],^,Z,\,[,Z,_& _gly,[,_,^,`,b,_,a,`,c' _ala ,`,c,b,d,f,g,c,e,d,c,h( _asp,d,h,g,i,k,o,h,j,i,h,l,k,m,n,l,l,p) Egly,i,p,o,q,s,p,r,q,t* Eile,q,t,s,u,w,{,t,v,u,t,x,y,w,z,w,x,|+ Ethr,u,|,{,},,,|,~,},|,,,,,, Eval,},,,,,,,,,,,,,,- Ehis ,,,,,,,,,,,,,,,,,,,,,,,. _leu,,,,,,,,,,,,,,,,,/ _arg ,,,,,,,,,,,,,,,,,,,,,,,0 _glu ,,,,,,,,,,,,,,,,,,,1 _asp,,,,,,,,,,,,,,,,,2 _arg ,,,,,,,,,,,,,,,,,,,,,,,3 _arg ,,,,,,,,,,,,,,,,,,,,,,,4 _his ,,,,,,,,,,,,,,,,,,,,,,,5 _ile,,,,,,,,,,,,,,,,,6 _thr,,,,,,,,,,,,,,,7 Hasp,,,,,,,,,,,,,,,,,8 Harg ,,,,,,,,,,,,,,,,,,,,,,,9 Hasp,,,,,-,,,,,,,-,,-: Hval,-------------- ; Harg -- -- - -- - - - - - -- ---------< Hile- ----------------= Hleu------#----- --!-"- - -$> Harg --$-#-%-'-.-$-&-%-$-(-'-)-(-*-)-+-*-,---+-+-/? Hgln -%-/-.-0-2-7-/-1-0-/-3-2-4-3-5-6-4-4-8@ Hthr-0-8-7-9-;->-8-:-9-8-<-=-;-;-?A _ile-9-?->-@-B-F-?-A-@-?-C-D-B-E-B-C-GB _gln -@-G-F-H-J-O-G-I-H-G-K-J-L-K-M-N-L-L-PC _thr-H-P-O-Q-S-V-P-R-Q-P-T-U-S-S-WD _arg -Q-W-V-X-Z-a-W-Y-X-W-[-Z-\-[-]-\-^-]-_-`-^-^-bE Emet-X-b-a-c-e-i-b-d-c-b-f-e-g-f-h-g-jF Easn-c-j-i-k-m-q-j-l-k-j-n-m-o-p-n-n-rG Eleu-k-r-q-s-u-y-r-t-s-r-v-u-w-x-v-v-zH Eglu -s-z-y-{-}--z-|-{-z-~-}--~-----I Emet-{----------------J _ala -----------K _val---------------L _thr---------------M Hasp-----------------N Hglu -------------------O Hmet-----------------P Hval---------------Q Hasp-----------------R Hile-----------------S Hala -----------T Hcys -------------U Hasp-----------------V Hile-----------------W _lys -------------------X _pro------------------Y _his,------.--.. --. -----.-........... .. .. .. .. .... . Z Ephe --. . .... ... ...............[ Ecys .............\ Ecys .....!.#.. ...".!.$] Eleu..$.#.%.'.+.$.&.%.$.(.'.).*.(.(.,^ _val.%.,.+.-./.2.,...-.,.0.1././.3_ _pro.-.3.8.2.4.6.9.3.5.4.3.7.6.8.2.7.:` _glu .4.:.9.;.=.B.:.<.;.:.>.=.?.>.@.A.?.?.Ca _lys .;.C.B.D.F.K.C.E.D.C.G.F.H.G.I.H.J.I.Lb Garg .D.L.K.M.O.V.L.N.M.L.P.O.Q.P.R.Q.S.R.T.U.S.S.Wc Ggln .M.W.V.X.Z._.W.Y.X.W.[.Z.\.[.].^.\.\.`d Gglu .X.`._.a.c.h.`.b.a.`.d.c.e.d.f.g.e.e.ie Bval.a.i.h.j.l.o.i.k.j.i.m.n.l.l.pf _thr.j.p.o.q.s.v.p.r.q.p.t.u.s.s.wg _thr.q.w.v.x.z.}.w.y.x.w.{.|.z.z.~h _glu .x.~.}....~...~.........i _gly.........j _gly.........k Bleu.................l _asp.................m _val...............n Gala ...........o Ggly.........p Ggln ...................q Hval...............r Hasp.................s Hlys ...................t Hmet.................u Hthr...............v Hleu.................w Hala ...........x Hval...............y Hgly.........z Harg ...../............./../{ Hleu.///// /////////// | Hala // / / / // / / / /} Gasp/ ////////////////~ Gval/////////////// _gly/////!// //" _ile//"/!/#/%/)/"/$/#/"/&/'/%/(/%/&/* Eleu/#/*/)/+/-/1/*/,/+/*/./-///0/././2 Eval/+/2/1/3/5/8/2/4/3/2/6/7/5/5/9 Eser /3/9/8/:/</>/9/;/:/9/=/</? Eleu/:/?/>/@/B/F/?/A/@/?/C/B/D/E/C/C/G Ephe /@/G/F/H/J/Q/G/I/H/G/K/J/L/M/K/N/K/O/L/P/M/P/N/O/R Eile/H/R/Q/S/U/Y/R/T/S/R/V/W/U/X/U/V/Z _asp/S/Z/Y/[/]/a/Z/\/[/Z/^/]/_/`/^/^/b _ala /[/b/a/c/e/f/b/d/c/b/g _asp/c/g/f/h/j/n/g/i/h/g/k/j/l/m/k/k/o Hphe /h/o/n/p/r/y/o/q/p/o/s/r/t/u/s/v/s/w/t/x/u/x/v/w/z Harg /p/z/y/{/}//z/|/{/z/~/}//~///////// Hgln /{////////////////// Hile///////////////// Hasp///////////////// Hala /////////// Hala /////////// Hval/////////////// Hala /////////// _ala /////////// _gly///////// _ala /////////// _pro///////////////// Etyr /////////////////////////// Eile///////////////// Eglu /////////////////// Eile///////////////// Ehis /////////////////////// _thr/////////////// Hgly///00/000 Hala 00000000000 Htyr 0000 0 000 0 00 0 0 00 00 00 00000000 Hala 0 0000000000 Hasp000000 00000000000! _ala 00!0 0"0$0%0!0#0"0!0& _ser 0"0&0%0'0)0+0&0(0'0&0*0)0, _thr0'0,0+0-0/020,0.0-0,00010/0/03 Hval0-030204060903050403070806060: Hleu040:090;0=0A0:0<0;0:0>0=0?0@0>0>0B Hglu 0;0B0A0C0E0J0B0D0C0B0F0E0G0F0H0I0G0G0K Harg 0C0K0J0L0N0U0K0M0L0K0O0N0P0O0Q0P0R0Q0S0T0R0R0V Hgln 0L0V0U0W0Y0^0V0X0W0V0Z0Y0[0Z0\0]0[0[0_ Hala 0W0_0^0`0b0c0_0a0`0_0d Hglu 0`0d0c0e0g0l0d0f0e0d0h0g0i0h0j0k0i0i0m Hleu0e0m0l0n0p0t0m0o0n0m0q0p0r0s0q0q0u Hmet0n0u0t0v0x0|0u0w0v0u0y0x0z0y0{0z0} Harg 0v0}0|0~000}00~0}0000000000000 Hile0~0000000000000000 Hala 00000000000 Hlys 0000000000000000000 Hala 00000000000 Hala 00000000000 Hthr000000000000000 Htyr 000000000000000000000000000 Hala 00000000000 Hala 00000000000 Hgly000000000 Glys 0000000000000000000 _gly000000000 _leu00000000000000000 Elys 0000000000000000000 Eval000000000000000 Easn00000000000000000 Eala 00000000000 Egly000000000 _his 00011101101111111111111  _gly11 11 1 1 1 1 1  _leu1 1 1 1111 111 1111111 _thr111111111111111 _tyr 111111'11111 11!1"1 1#1 1$1!1%1"1%1#1$1&1%1( _his 11(1'1)1+111(1*1)1(1,1+1-1.1,1/1,101-101.1/12 _asn1)1211131519121413121615171816161: Hval131:191;1=1@1:1<1;1:1>1?1=1=1A Hgln 1;1A1@1B1D1I1A1C1B1A1E1D1F1E1G1H1F1F1J Hpro1B1J1O1I1K1M1P1J1L1K1J1N1M1O1I1N1Q Hile1K1Q1P1R1T1X1Q1S1R1Q1U1V1T1W1T1U1Y Hala 1R1Y1X1Z1\1]1Y1[1Z1Y1^ _ala 1Z1^1]1_1a1b1^1`1_1^1c _leu1_1c1b1d1f1j1c1e1d1c1g1f1h1i1g1g1k _pro1d1k1p1j1l1n1q1k1m1l1k1o1n1p1j1o1r _glu 1l1r1q1s1u1z1r1t1s1r1v1u1w1v1x1y1w1w1{ Bmet1s1{1z1|1~11{1}1|1{11~11111 _his 1|1111111111111111111111 Eglu 1111111111111111111 Eleu11111111111111111 Easn11111111111111111 Eile11111111111111111 _gly111111111 Hhis 11111111111111111111111 Hala 11111111111 Hile11111111111111111 Hile11111111111111111 Hgly111111111 Hgln 1111111111111111111 Hala 11111111111 Hval111111111111111 Hmet11111111111111111 Hthr111111111111111 _gly111111111 Hleu11112211112222222 Hala 122222 22222  Hala 22 2 2 2 22 2 2 2 2 Hala 2 2222222222 Hval222222222222222 Hthr222222!222222 222" Hasp22"2!2#2%2)2"2$2#2"2&2%2'2(2&2&2* Hmet2#2*2)2+2-212*2,2+2*2.2-2/2.202/22 Hlys 2+222123252:2224232226252726282729282; Hval232;2:2<2>2A2;2=2<2;2?2@2>2>2B Hleu2<2B2A2C2E2I2B2D2C2B2F2E2G2H2F2F2J Hmet2C2J2I2K2M2Q2J2L2K2J2N2M2O2N2P2O2R Harg 2K2R2Q2S2U2\2R2T2S2R2V2U2W2V2X2W2Y2X2Z2[2Y2Y2] Hglu 2S2]2\2^2`2e2]2_2^2]2a2`2b2a2c2d2b2b2f Hala 2^2f2e2g2i2j2f2h2g2f2k Garg 2g2k2j2l2n2u2k2m2l2k2o2n2p2o2q2p2r2q2s2t2r2r2v _arg 2l2v2u2w2y2v2x2w2v2z2y2{2z2|2{2}2|2~22}2}2 _asp2222222222222222 _leu22222222222222222 Eleu22222222222222222 Eleu22222222222222222 Egly222222222 Eval222222222222222  Easn22222222222222222  _ile22222222222222222  Hasp22222222222222222  Hhis 22222222222222222222222  Hile22222222222222222 Hala 22222222222 Hthr222222222222222 Hleu22222222222222222 Harg 22222222222222222222222 Hasn22222222222222222 _ala 22223322223 _arg 233333 33333333333 33 3 3 3 3  _gly33 3 333 333 _thr333333333333333 _ile33333333333333333  _tyr 33 33!3#3+3 3"3!3 3$3#3%3&3$3'3$3(3%3)3&3)3'3(3*3)3, _pro3!3,313+3-3/323,3.3-3,303/313+3033 _asp3-333234363:333534333736383937373; Hpro343;3@3:3<3>3A3;3=3<3;3?3>3@3:3?3B Hval3<3B3A3C3E3H3B3D3C3B3F3G3E3E3I Hgln 3C3I3H3J3L3Q3I3K3J3I3M3L3N3M3O3P3N3N3R Hala 3J3R3Q3S3U3V3R3T3S3R3W Hala 3S3W3V3X3Z3[3W3Y3X3W3\  Hphe 3X3\3[3]3_3f3\3^3]3\3`3_3a3b3`3c3`3d3a3e3b3e3c3d3g! Hile3]3g3f3h3j3n3g3i3h3g3k3l3j3m3j3k3o" Hala 3h3o3n3p3r3s3o3q3p3o3t# Hglu 3p3t3s3u3w3|3t3v3u3t3x3w3y3x3z3{3y3y3}$ Hgln 3u3}3|3~333}33~3}333333333% Hala 3~3333333333& _gly333333333' _ala 33333333333( _asp33333333333333333) Egly333333333* Eile33333333333333333+ Ethr333333333333333, Eval333333333333333- Ehis 33333333333333333333333. _leu33333333333333333/ _arg 3333333333333333333333330 _glu$33333333333333333333333333333333333331 _asp3333333333333333332 _arg 333333333333333333333333 _arg 333334333333333333443344 _his 344444 44444444 44 44 44 4 4 4 5 _ile44 4 4444 444 44444446 _thr4444444444444447 Hasp444444#44444 44!4"4 4 4$8 Harg 44$4#4%4'4.4$4&4%4$4(4'4)4(4*4)4+4*4,4-4+4+4/9 Hasp4%4/4.4042464/41404/43424445434347: Hval404746484:4=474948474;4<4:4:4>; Harg 484>4=4?4A4H4>4@4?4>4B4A4C4B4D4C4E4D4F4G4E4E4I< Hile4?4I4H4J4L4P4I4K4J4I4M4N4L4O4L4M4Q= Hleu4J4Q4P4R4T4X4Q4S4R4Q4U4T4V4W4U4U4Y> Garg 4R4Y4X4Z4\4c4Y4[4Z4Y4]4\4^4]4_4^4`4_4a4b4`4`4d? Ggln 4Z4d4c4e4g4l4d4f4e4d4h4g4i4h4j4k4i4i4m@ _thr4e4m4l4n4p4s4m4o4n4m4q4r4p4p4tA _ile4n4t4s4u4w4{4t4v4u4t4x4y4w4z4w4x4|B _gln 4u4|4{4}444|4~4}4|444444444C _thr4}44444444444444D _arg 44444444444444444444444E Emet44444444444444444F Easn44444444444444444G Eleu44444444444444444