6,3.6-1h/data/swissprot/ 3GSD.pdbdupa 1NAQ.pdb?X[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]2.05 Angstrom Structure Of A Divalent-Cation Tolerance Protein (Cuta) From Yersinia Pestis[/h3] [p]G.Minasov, Z.Wawrzak, T.Skarina, O.Onopriyenko, S.N.Peterson, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3GSD" target="blank"]3GSD[/a] [small](deposited on 26-MAR-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [p][!--icmscript name="26" display slide=slideshow.slides index="Ligand binding site 21" --] [a name="26" href="#_"]Ligand binding site 21[/a] [/p] [p][!--icmscript name="27" display slide=slideshow.slides index="Ligand binding site 22" --] [a name="27" href="#_"]Ligand binding site 22[/a] [/p] [p][!--icmscript name="28" display slide=slideshow.slides index="Ligand binding site 23" --] [a name="28" href="#_"]Ligand binding site 23[/a] [/p] [p][!--icmscript name="29" display slide=slideshow.slides index="Ligand binding site 24" --] [a name="29" href="#_"]Ligand binding site 24[/a] [/p] [p][!--icmscript name="30" display slide=slideshow.slides index="Ligand binding site 25" --] [a name="30" href="#_"]Ligand binding site 25[/a] [/p] [p][!--icmscript name="31" display slide=slideshow.slides index="Ligand binding site 26" --] [a name="31" href="#_"]Ligand binding site 26[/a] [/p] [p][!--icmscript name="32" display slide=slideshow.slides index="Ligand binding site 27" --] [a name="32" href="#_"]Ligand binding site 27[/a] [/p] [p][!--icmscript name="33" display slide=slideshow.slides index="Ligand binding site 28" --] [a name="33" href="#_"]Ligand binding site 28[/a] [/p] [p][!--icmscript name="34" display slide=slideshow.slides index="Ligand binding site 29" --] [a name="34" href="#_"]Ligand binding site 29[/a] [/p] [p][!--icmscript name="35" display slide=slideshow.slides index="Ligand binding site 30" --] [a name="35" href="#_"]Ligand binding site 30[/a] [/p] [p][!--icmscript name="36" display slide=slideshow.slides index="Ligand binding site 31" --] [a name="36" href="#_"]Ligand binding site 31[/a] [/p] [p][!--icmscript name="37" display slide=slideshow.slides index="Ligand binding site 32" --] [a name="37" href="#_"]Ligand binding site 32[/a] [/p] [p][!--icmscript name="38" display slide=slideshow.slides index="Ligand binding site 33" --] [a name="38" href="#_"]Ligand binding site 33[/a] [/p] [p][!--icmscript name="39" display slide=slideshow.slides index="Ligand binding site 34" --] [a name="39" href="#_"]Ligand binding site 34[/a] [/p] [p][!--icmscript name="40" display slide=slideshow.slides index="Ligand binding site 35" --] [a name="40" href="#_"]Ligand binding site 35[/a] [/p] [p][!--icmscript name="41" display slide=slideshow.slides index="Ligand binding site 36" --] [a name="41" href="#_"]Ligand binding site 36[/a] [/p] [p][!--icmscript name="42" display slide=slideshow.slides index="Ligand binding site 37" --] [a name="42" href="#_"]Ligand binding site 37[/a] [/p] [p][!--icmscript name="43" display slide=slideshow.slides index="Ligand binding site 38" --] [a name="43" href="#_"]Ligand binding site 38[/a] [/p] [p][!--icmscript name="44" display slide=slideshow.slides index="Ligand binding site 39" --] [a name="44" href="#_"]Ligand binding site 39[/a] [/p] [p][!--icmscript name="45" display slide=slideshow.slides index="Ligand binding site 40" --] [a name="45" href="#_"]Ligand binding site 40[/a] [/p] [p][!--icmscript name="46" display slide=slideshow.slides index="Ligand binding site 41" --] [a name="46" href="#_"]Ligand binding site 41[/a] [/p] [p][!--icmscript name="47" display slide=slideshow.slides index="Ligand binding site 42" --] [a name="47" href="#_"]Ligand binding site 42[/a] [/p] [p][!--icmscript name="48" display slide=slideshow.slides index="Ligand binding site 43" --] [a name="48" href="#_"]Ligand binding site 43[/a] [/p] [p][!--icmscript name="49" display slide=slideshow.slides index="Ligand binding site 44" --] [a name="49" href="#_"]Ligand binding site 44[/a] [/p] [p][!--icmscript name="50" display slide=slideshow.slides index="Ligand binding site 45" --] [a name="50" href="#_"]Ligand binding site 45[/a] [/p] [p][!--icmscript name="51" display slide=slideshow.slides index="Ligand binding site 46" --] [a name="51" href="#_"]Ligand binding site 46[/a] [/p] [p][!--icmscript name="52" display slide=slideshow.slides index="Ligand binding site 47" --] [a name="52" href="#_"]Ligand binding site 47[/a] [/p] [p][!--icmscript name="53" display slide=slideshow.slides index="Ligand binding site 48" --] [a name="53" href="#_"]Ligand binding site 48[/a] [/p] [p][!--icmscript name="54" display slide=slideshow.slides index="Ligand binding site 49" --] [a name="54" href="#_"]Ligand binding site 49[/a] [/p] [p][!--icmscript name="55" display slide=slideshow.slides index="Ligand binding site 50" --] [a name="55" href="#_"]Ligand binding site 50[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1NAQ.pdb3GSD a_3GSDB1  1NAQ3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  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}47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iᅩ JzyBJG?WO ,U7,w`ٲxJ+zxlzŔ6h!~L*/yx9ר]p+&.,3z~Cq/ӡDꎍ ֵwaw=ZP b5w|Up9}|_9W)/%<3ꗚ /]} HL]GLyV AA#O ޵шnekev`#]]Afg?@X%o1_.Z ŋ?Y*\=tҴ]` sbhҾwenlJ{;q\}t!t(mrq'FWiڴ)jqqFߟ%@73t;x!`p49Ϟ>oE*>AH8VP"]ZHn iYO=8&it;o'a("wqmfEPd(ԡÝG7W huyӋ.F~^%6Ѭ<=}^W1uֳ%<]bD">Ky}խ'ݪ {ohYM:~ÄlJxo(M_dnF"~hmNоצ+P+@4OĎq&0 ;F {'7D.0ݞ"4ا8//6DѺP bٲe7fg9!cLh߁X?sYzG<6K< (8XځW;=jO@ks>Nfun,:76_{$a3?[GݵkwCs66<Ǿ+ ./A|eIOP7=l\/sqJKUq*?Ao9P B%_s}:7 -|Fx>B[tM>{V54=c9\ZīTܼ͛<`wSX j;l=oЦH~S=}L]Ƥ7bPud6iw M:!K4+-ڢiQbs00o콝 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Dӻtt3.vE CiРZرcs/:lf&SdK=0n ǒd&~ Ck&Mbڈ6 Vno=эhj y/BAm<ŀFN_z8{#BAn-"MCAt0={֦S's\1+ŗB肗HWUcR4hlf ׎^: @(Q%kT݊!g/7NwowR`0N6I&9û vHǦ5-E:FKx&[yL^ܿaD*q1Jb181 b.q]¢ط/|#!TA*2ݿŚd;_.]~j|>f*sΥNL]iӦl?rd `/kդd+n>hǒ%.-P$4ReEPxzzMa2oCfP~7fLp2=F}[H[2<r4|x fP},(XLR.#7#A,aB(V {N`I֒Q u6]8P6UDڴd=[gRg@*ia]N|9ܡx&vBEKy=FPHJd HBtdBwzUH]'[N:lRh6J8ǯ3p`cjumʑ#pvoo+B {ݴΜC{QlÂ`>x4B)|I' 6Myy Ç#v! d=I\L&Sc_M]Ưے-NbG\cϧIxy͵ےҺn ~gΜ9åK}6FeMHtT*vo _`ȣ xAO_O.8toS2Lsg8?@o;V>?'ORtiFVAQT4](퍑kW6 ~B^S$ܰa^^^lڴ)-f#gM'/|9s M~qEn DDU<ՙIX)-EwË%lي|Q[ضmҺu-#F 00XB CCƔ9םJ?Pd9lW +/)ԭ;fթx  ;wߟs ܾʠ"Sd~E2 W/l ²eh6pڵk[nC@K|gbʕbʔ)b|W-C*qN*:wUdYQv_\?/m۪?eDqx *QSp^yQBƫD n,j7I],ĺ{Ms?m9 'K,W^ܽ{k׮X8ݻS^=vO/0{d]L҅2iEJ%o\}% F!""@MM3Q,PLK r\L8k.R28};n+of43.!**ʃgh"3f ~÷o0SWf_kd~!(3'o>x*xV!B 3oQ74;wO OKd~{"kH\̔I{; 3lڴ*&v^W]m*yhDGRR\&압dff2Y"py>^=I0HႠF]\_ Jk P1dn S8 Üܦ@Pw]v&a ݕ=z5MdνqΝ;)))7Pd~q,w8 \n_FG -mG>n:=ESwWH=dpL~3 vԑI.jQƙ|gNPTTDUU痢gƀJl:T_իl@,T[)DF;n4 f:Lp] lv9Q` PT#zk+Rr.RӁȝز,?*\6Պ /\ߔBC C-Pq,}(B Arm<u &Dg6+]*X]h {Ȥq8m$map!ţ"?i<ےmnfjRv -¤vyٹd\ 1ѓJo:*0%}:!QZ-.$ iֵ s5QU ["w<`Wx8n^ݡGln ع΀U5}81'@Vl6䆩dwU( m2{ovב]VSgjfRpư -$ | ^趗 ̳y{ϑ=fp8~9LLCӢh%S6xOh1&4aTurYS< 3h~@`h!X<b{-'XSK; ׾sD<1a=0zF&^(Z46rGyﻑn,d Q #vkw#-7&6:Gl1j֨ }!imQii@tuDxYH m 媾td n2mhehjaRc$xaBh@X` ]|j~"yIENDB`move=1000;blend=1000;3GSDB1N k  UWUU_jU]WUUZ_jZUUUUu]UUkWjZUUUUu]UUkWUUUUUAUUUUUEUUUUUUk ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD %/ %/ /֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&UBt,cf UQ$I$H5QI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDDET@I$""*I$I$UUUUUPj$I$DDI B" UDI$I""*"DI$I!HdDEUTI$I$"DDUUUTEUUAI B""DET@TI!UUI$I$5UUU$I$2" DUDI$$I$@DEUUUDUUT$$"" DUDI$UUI$I$5UT!I$U$C""*I$I$UUUUUPj$C$$$UUI$I$!UUPj$@HDDAI$$I$DDUUUTEUUAII H$$=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 ?333333?333333?333333???????@???ǿ$??O@ C.??LI?LI?LI??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residuesUPNG  IHDRc IDATxwx\wVھ޻%ےl˽WlCoz'Ԑ[$^j0qjm?V^yٕ\^G̩{t93sf@/TG_.w4GN44~4b>m sI&] iii2k!8' ?GCI듢ٯ*+{S_DaLnAVtcaaDF%x<_lܯv( 'd ~ #G^[o](44| ȑ߲dXHk[Nc۶GrZ n:X9k~_~s~y)2ha8m8p&xIJF{v,X&D;.tpؖ_]vb9GGB,#oIi~ Y{w쳽+BL5VQ_v|ko_HK'45}<w7^oSԺ&9ԥ#@Q"JZZ*"<>7~ôY蜜xU7/PQs)-[3b0ں{Q=D\8;n$ ~C|(JE`ҳ"&S2pŘLWrmok{⋽k1b\~aYK$99srJll9!aÆz6`(bq:;C$>Ĉ6eg.B?_B"IL<efN>|!4Q,csk_=Կ<V*ÇGSu:l'&@{&O`.2oD%iizss_9D~M1ϐoC/ . 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\<&kK8R7%@@ B8#VB)FO1*#'= ZY^2 pt N@ (D >r# \ͧX@ xGGJgq_: =HPTZ[uZ4Hp'i7JmrIIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ UUW **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1S֪B¥USZU:5/UO֪WZIU:5/USU֪RUN! i֪BUT֩?UN! iU?ZU_j'֪uU$!/U?ZU_j'֪uU$!/KUTjUU5OUSHCZ_֗UTjUkTZUT/UO֪WUSZU:5PU5OUSHCZ_UTjUU5OUSHCZ_UT"DDDI"DHDB""D@$$H$"!" AH "B""$A$D $HDDH"DH! "B""$"DHDB""D@$$HDDHAH !&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???ii$??@5LrQ@9@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 28PNG  IHDRc IDATxw_3no{/"*(آF1X$&11ƨ%1F EWn#ٺ{uc-Zs=ǭѣ0 a// ?&_AO0@Um[1]ר(!XŸm)i?\⼞lycx >lr+FkwM@$IF$x ؾo]gt&qm[itW6mvܮl;s$YdMm1h"9TU@Z#%m۶ Jr,q?iQ9DMQRYRP{{G8\HH.4t M !6OT@ &O̧~,ېeƻn%~ u(ؐZ߂.#OzZN䋗$l sݩl45,]K. c׫3쓷Pd[,I' $7p7 ]BA_DŃpd P ssNuyGs*K@&% U oMOAeM\MSA4MEՓd6nHSSgu7p*7tSTm)#G0%:]|;M]BM (ӞsuY!?jRBϧƊTUU!2ܾX:$˝ρ@cNqBT5H߃?؄$Q +7n9y"IMIgu~<y4k<(|67A0`Ӂ?IރM0~Lx#4MSF݃@t >z wͮ'}B>|aÆ9s}VFzDMW.cx$ISO=^{Hnh$!T!Dd9(Vx0jA&nx/`͚5<4q?~<}Y}/zO>$/2cHdع^KgwV,dgY  I"/7$ARŸa*kSVX| ܙw*Ͻ~QM77mļ@#~ )\tb;k;￟?olG ] yo 6o֔]RP_'^PdxӿdonV)tY,FjJ:jv3z|ҹ?)>qzst]n^^eQ\ve-bEAr׿r5״}%PUUijj'LгdYƝ}Nbc->Aoܗ?Є/Ј@ij<Ѧ_X|~[G4P5ft!K27/%?΅B,{[=GUUn6w.LT_`ժUtM5Gy$0qmkᡇ6|֯_ҥKyp08O? O?q[ns"!ckm,t.ttME4!tjA4]~Z6U (vdI8ڴhw}/s9k"1bg=~ժUG?b̘15*fW\)Sxgb7o|1|ĽZ E3d8e8niB+9=Щs^0'h$l"bOasbӛ(r)q˳>--G3fh".2kYk0zu,X V\ɪUZl;w.g駟ꮺ*{1ꪖ^uUc;< *#@QnOTM5x iG.ضl2O6n8>l,Yys=g{i߳g˗Ò%i,Xpgn]?tx_$ˆYxy aX 1BKΙUJHp8Iq(jv^~ϫ}={6n,}w#&˗CfΜ_n'*Y:COtVl U AfLgZ lc+)v=h$+#n|(N.nָzބmo`(7ë>O,}ZI&1|cCΈ'$ȴu ̕%qS?Q dö6TQPT;`S5"m$+\ZI=sW?ZLqУG g3yA5n Cr egSSAAN9=bms1Ǒ"[dCVlyR̓o='lrSpRǫ_el |嗱gXaŜwyQKThGMNj(lvA$ ˗ۼIeYR(M $(2 +c` GŇdSVЗ'Ֆs4Ѯc`Lsy,5|dx5FCyX͞opSqS^tH{/_l5Q[mFoi$Jא9xOҡxG18ӝMn/1c2x ÞRۓՉD &Db盝+O㏳[ \|1NO#I&<˓36j*q1s3w\H Ŀ2m3?U[vȓU$I CDOs=ͱK2gfj0r9xUT+[Fbz. SLo߾̝;~I`X74MrIJ&/H(odg0E'믧:i,jp0jp7o^ˍ! wQv+Fw}7&/?͒%_ qmG7(sάcٲe ϔ>пaTB#s]j.xkHwe@nf Vғ^6z[#X~vYgߟV}ꩧ?qJ݁2qD6m2rK>Yؿ̱~*w>e\1%|!#몎2gm4_m8FI"Y֍h 0.Z:ޗ|7RZZʇ~ә={6{. ."a_cq> IVeЍ1kt<}+FQQ</$ku IuطC&C9餓b"Zcú?9[P:ud B,X9??D*)Qt$]:@ʒ!.Qp.sΈI,prϑ#G駱nSz0 O笳2 9%"@~~>cƌO?%Ge1 itt! +OV/ &l'<꺽fUDoSj`ȏbp fp2`w(AUt-~kF wSÞj$L b!QGu2qVbˮ{4͈R;N{J{‰ @EI%8֐C!Ħؑ$mnstkj#^܅Q!,jGfSo,cs[裏|>Q-2$hkVI~J a"%%]T,fHq9͕IZjN{*6V ٶ{ n3pr4F K(E_,S&v)S`Hlڲe |:ө}vlG }o3thGYoDs=!'IH dow氧j,I#cw&,yM?l$d ;~<7p^z)e6ZOӞQyYؾ+E2>֐.KYrɛ%BMc%yrF}hvNqXo-9ܮϭeno3p8yB~RnT=Ŀh==\yaWImvY!}NH<9(~$Tm ?(.g]ܒ$SZ؏>87YPMWsVu@'8U "!d^۶g-zCN:Ͽn; =&HK;/JHUty$Cg0qķ?ZVmz8XeO7 g7.t<Fز꡻@44=}4(/GP <Qp`pYI2vsW5 fWK;#"0V'Cd= vU X8 Ml'<N)*|W2$Iʫv /IDAT9Z1y#+tc,X`Se»IE]0'nc )7 $L~!E6,9p㥏Sq?>s]7JAo I8T'~W9ܞTnG`$Ib?F~x yuM׵ޯLlE1؋0U5fU;jv%ZzF pxyL鈼G)]@-{EPl+{qb Y6$͎|Klݵ\{$7>cyyl҅ 2s̸me8E6j=3ā$= H8ٻn1|}Ͽ=8]hlM24n<ۼ!Mg)G4=3kVΓ [)o- c2z5*6Ya_q/3d-|ۆ*P.M$94{uꏬ}U\n\tcq;"хO=zNNN.MMײwpkLj$"J|ADYWߦӹW#q\@j9YÑNtڕYB1k %%EWvvV{}Ri7+y_^h(2rYQSBBb. .a<͸W.4/D¤{JȉȨh d@SRz 2b$?l9ؘOmDSY4#k,eAzd=f|>/~?c=yٷˬDv&gG=H(gρͼw\ {/_~9_~9gqFSVf {`EF ӝ"P&RZUql:r*QJf`\d<}Z@0kB5M$_EU2\99ki eWb%de4u>5}{1~Uk,q.oLod IlDns6+i5" HY"HQ6Ń,S #'%&_>rGcBkdehƫ~?:^)I2㆞iaܲk|'F #i< yy%|&~dQ`.X"ALЭ:Nqc uqpy 9MQ3z/_yj#1&C߾w'2y\wu4gz=#w_mγʤ6 r 9%gW?V/Uߛ>#!c ]}wp qnN I^eCcΫ#t#L2>Zr9lOwX?Ivz!:.FmwJװ62C f:> SA$td #ˋ|cА7o CT]hH2/Xfܶg-A'Ŏ zU7A#HlNdpl-Ro8l] ! Y'+=:ϡ]ȺȲĢeOPpq?=`kU( lNKe`R)hfC4BP;rS0d( ̏.vpʓ7Y`K z8LՂ%ey ۺ0Ⱥ?IҊ0~&kiBJ tjQ'TFSUTEEHq`,;RKeg3 d hANx'{+7N$diA32Mx+AI Psxȼq0|46$$3B5{޸h 2`;w!E\#c4M:A3 [lt>e#:// @MصoK&c!<%Nwh45*{l{S9lΕ16f?qL/KA {:!5Jf<40m1?\x) }Oͼ^MSq빛E;G a5* :d;vY#-U h4 im(4`ϖFPߺչ:#i!Nvߚt GUPaYUWQ6n~gj{r>'NYoe!` b_:HHRx執ސ@7&{@2a>hHp xH7ӬVsF#zAiA['A`i0*kƃ&ٱA'/^JE ]b83/5&pfyON3"PC!|>/y ٖyT3D82P'@ۮ"ƌ jڲ #cj=ymv~P@mޕ@.Rx탇aB  a =g#Q,Wbwm®ty0%ezm7w³0ik<5Z<7~rm; 7O4v0L|Vgjэ%cf$R(zamN;R@IATt$aɲkmiL<YNjӷ]F&FCjǾmيMg)SF]G s=Mom++τ3)Ѿ"Å5i9))t{o$h[Q926%I 6֭?E/%8.;(¾ɕ?^`g(!W+t]Ʌ-3wTm楷`,+ǘg` a194"S}ƾS1EFLĕdIw\)nry)_¼y0&6TY6-K {(V]F? !tN6Th𿾖\v.7l_"p䐚MVn:B]71K^kNU$I9U?l|^V)%C 0y( \ҷcpm`Nl IPUU3|?h&_kv`;sOi Pnf!!M҅H˵2/hAf'ST1>RT x՟;aX2^uaC̮a]Y<DPߋ돬<6OfNt =iKTBjyN:] s P ۓHX г Ѵ W]"ž[XtG`tQp=G#cgͩK/mvԔTRS]D  Xqݣ+=.]A$z cMNm~OH,)47 `XI ;+Zx|!;W&_=N@ۡ6B!Gg_/,lL%+8NkfS:nӯX^'r $FxYjDbNt@Guk~^hQDyESVܛᴧ A],'%5o>bdW "۩ߏ;# <#N]Ȃ:xeP&$2 Ko3rD(+GP У? .'řae};Blìi|"w!<Nascr*NytPl٣Q2BGXK]8 "SWJ_,S餥f1"&|͟pY&N; .G(+3=چ|Me*Vk)j{h_oOS E`{`% ?h9rWj{QZpB= _eSb֝]9r8**YDSjJH1 kPPŊuoP]{wpt3ܿ5TMyay+N_lޱ"Gi,4M$]`UU,At]'t {x xT$vXNk-Z˜V^MZj&~0vșC~ +p:]˷kFvHE@aTЄƙ']MH ˏ&) 4 Hg{KvB ŕⰥC32#1 Fpn>?Lt*IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDn%/ %/+ UUUUUUUꪪU_U_UUUUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU 'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>RJ¥USRWZ*U'¥PUT*!T*Z_jT*UMju]UIkKZ_@jT*UMju]UIkKJU_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWUWfW #"UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???QYQQ$??GH"?@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3 PNG  IHDRcIDATxy?YD@D\QdK|FQ0*KL̦Iq~I8Q'13W5j[DF\@DQVi^sSvns:U[qR(%y[_<(=n9Xie2(RH%QV iƶT6wB;_YS*$r+*kR >e$OQD)__Qa+<3yiJjȓLHg[8A@sBJ=21[Vew$ϯ<&*pB[(%y|D-gѯh#̘<+D$-e;ǶG#TvRyCR!RR+!4'M2-LMof z~R@YJR򷥷E-oFЯh꜉i͓dq#md qNX%Th|LZeYZ>w+ǐZK@)mڥ*Wwrg#8eYJ!OPAjyu'#$;|#@TLH@qĖtLͳ+ xiؠ1qCX1+u, п*++XB 0mt9$^1+*y\1\H19E"5ar[d\/FqaihOfeby OVZ~E0 01 &!C^?)v2# CM)gv =_k(*(0LF;X@l]\/iX9|m Bvl]<FMujOu}!;n~%PGЯh #ʶ]QVhMlD="00"ۺ8-iv|g\t+lT16 yx> _vIe>d ){`̈I~G-P]և/W u% JpKH%01 !{eW#9T'4&zSMc'IjQ\Pp#D207l5Q0rhOp6YPdxWR83C.vmϽ]N CmD)pfn3%#j(=dl sDu~܋CI'D$?2!BFp\p|3:O +Drs\4퇡!nbplvL)' ؂#ݲiꈥZduĘJt9 uvd'^=[tMh _۴6o_Cߓatԛq\B}̹JM$<ʝ]!No׭5r)֘&g;F+t$ a0A]uײy'D7_vrs PyhJ)v)Ҵmw XE`9q>F'򹁨S/ i7єh]FjQ mQ<810iL@]hZı3򙧜GnůPm ' >Ֆ(BM#f D f5B6lyC3hjb׾͎i默h{qCDO Ϳ1 o} 5TUo!HTڌi+!bn!q&_:q|hTlڶ˴7wYo]#P7@5!_o҇-+@LvʙxAE-D2EN:g-I&"!ZpˌsьG-R8TstϨaw]`{]CtQ&A|J@hXf(gD M [anϒE5 9^rqzAWJaMB؞}82$[ iM ;Il-@[wE3~HmpM&ҺƤI ,u m;XQ6i^"Rѡkkk)r9J2I ޾%Ϧm<ӕ~ 7ʵr'[ ƍǖ-[8rm]@ KھiA +=m^gŚ'">Rvsꩧ2k, .<_γHP M6ȈOZP}"}4455k׮ @S(#%6C"ȁV[xy2yغu+nԢpf  M-;{(8ŧ`߾}k 4ۥ# r<Rw75:O|"cH~ʑ#G#ƃ>C;<.Euu5]*ggС"+G>y-vժU^ (//'Hb |ImӴ2cr 'hѢɚ)˃^LpJaLt1Μԉb$d?9{W_e͚5<,[,D9/m; |0Eee%7#FfKF{mFGmF.H.;s&ҥ~9s2"¹?O"_O䪫t;wr;y3nϭש8#"~C8Xu<}W!b<&sJ088e 硇]_޼yS˗/g۶m=>K/4t~"Ȃd#alBj8PD}+Nډ Jyۯn f>WNǐ!CЁ5UNujlZAee-kY9'3bwM+i8 PJДsɱ ^Ø?>VF~O>$}K.{xذawݥS=補||_͢ԭ2xp1'xCO632v ~ϑKK4%ɋ ;E: wu5ro&^&{̝;#ٳ~Y`3gh:ضd*vbmi)))7v kFƐ&v=ުׯo6Ltٲe,\ݻwSVV[ošC̆m+D)EuuCHIJe0xp_ѵUڃ4bjwH:￟2K*++QJѮGoM]]/Թ<3Zkn]E&.^x>|kKb6K"U@CCZJAY+<}3=TvBgf!{ÕnJ`ec`aV%GfQTy믟ԩ0o~sAEi ux<)& Ol7 f[N̙ q@1?=JKTR&m[»C޽'Z`tH&(~/lX>OA~_8X.T2Fq啓0 AE^}KΝ DN)\stmlgO0v#3Amfz39|Hۗ٬BCGq o*/$tHsND)EMM#Zv(9EB`qbVKx/B,fА`ŊkwutjNume(>Dz>3I&m**r"mw+RHPӌ#TE|E|N\SnXlDJ[W0,?nT&dq;w"W\1&+r$raљ I$ D4),^x4>}$9c~0$l }[Ĭ82c@J K8PR!O?ݍW?&C -jHM$I,3d=￿kٶq׿^HB͖w!>6q rwo5{#2c^{{>/Xm' h!'e=lBn#kW~Kd#vDD݄-)3 GŨ^ڄmڴC0DFT4LbVX>1+i1leH/w#`Z<Ϛ9"; y &1K.b^kL4L&>^6nm0 89?k]y\`1+x,x,_ȰR绺w3 ))D-L;(GꪰeD= M44ҔlksƍmQr/5t(wG-L;uDqa)a0)ȖǞ? đ#ٽc@i c<)QO,m'eczwʣx0u!h3p!D.yV>X>3M )mli3d, h9OGn!26c91+!im'u7DJ>!0&T)m 'o,+Ň;Yia`KeE-f/y@20f!aXHecQ r<. K& idr_8SwZ;Z2fOEf([ p4R=彣@ΓEay\2fL/﴿rGBc67RvJ*Ɂw@ywC"~ypW@& IyE<&-zƆK/m:ߠRRU/j1{4-y0e0=" t@bXtk I9cMjOE׮i(J(E"سߜ,Ǔ@)H9$'C=o1A>G[P#\Cr<>|z>xuz2Eٛ 8mSf+*za(7^AR8 <najk0IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ UU **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iK§USUJIU:5/USU֪RUN! i֪BUT֩?UN! iU?ZU_j'֪uU$!/U?ZU_j'֪uU$!/KUTjUU5OUSHCZ_֗UTjUkTZUT/UO֪WUSZU:5PU5OUSHCZ_UTjUU5OUSHCZ_UT"DDDI"DHDB""D@$$H$"!" AH "B""$A$D $HDDH"DH! "B""$"DHDB""D@$$HDDHAH !&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???kk$??AI@`=@? g? g? g??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4$:PNG  IHDRc IDATxw\UNۙ^d7 I%x( EDQExQT  @$Mާ{~23;mv!yu2wn9;==r 9Q;œ8nJJmF8 DJ Huԇz  ݦLwU@%%ڇ0OvSRBJIA(FE @ L6*s9V#ii)q')I()8 BF@k>HN4hU'!ӓt=ڇT-ۖua(bCF ilߜfzMPe_t Wp$d<'9^&FvQO9maL\& wjc0U( 0(6QU#mpҪKDdzrH=,zv3|Ӯ#i*3/ٙE3F{gZb$@ۈy. O͉v6oaҪڦC8).<;4[<(`tZ &d6e`B|1`GJBxyvB[g#~<󦝗jaߑt[ IP;p 5iE(lv@U# KU6hl{>5H4k(F$"hl\r,o>h`2i6h uꓖ2=ֱaE݇ޢq`ݺ cFN5^#0srƕ}%f71䇞U㇘@&*/qkXt٥ߜvOKvܬ-I1n0 ysigygҺϛFDMjzb-M&:t5[*Kysm4-?;WU-u\Ra(@w]Gaؑ_z#PsƖF skN5\W)CgIũ04'Fx1ջO)$*PE棡j*IUi=eڄ #ʊ'?vۮPOk\M a `᭴w6᰻AQ^9pIon;auA;βO'^?μ\57x^vUBFp8\N6; Gaëp8pex굏v\ey1;_Ȁ Mm:'0p,\U}XDug G혯H[񋒮vsK8 3PTܬtZ)+D^<,<Yd8,DܧYHΈe'Uy 0"e]̲?E3=rBб(-$wҠ:Y3d+y`UOSqKؼX66jU$hA9BN Ɨ&Z??_ >Ԩ1ͧt:63WAmAkhHjͧ$9ͻ0gt9ڶ||*lE]>;Ivڌ@PRXŎdօ. C8.Fͤb4 /m_fzr@Ia%E!Hg 3X1UQvH4h/MC~B < ߸1.MEUU(B'M[GI]̺Up񫧿ٯw]1kLe#&ISҬ?D`k -EWp3X4s 9bz>]摟]6H{k&?{$g,Y @˫/EբƏurikkƦF~k}?DԋJjlx~Btd@ CO|gN E! v{~qن%,aY0sr:-؀zE1݇~hiǓE$$%?`+jvR6rjT]f' DBj>sQ\lvq˟P(EAn)9,"DCΉt;\[Å@5(=6 f|Eaٙ7_@C(†:3hlCJ-„1Lp8h㾟}@+Koll' |d"0Hp$=mYo !fzcLSz/2j^W̳#  jQBa? S`#0d*^wvZoomFTB Y< [j,}0H$B[K+pE}cO θ MSQ5\3/,鼙t-  wnW ŦXz_LWM0cMz<Nl`Ho! 4l[L,<||5lEL)crttÒ&ٍbL[0|L?KϾ E/þhDՁ{ fsФ?ʉ51lk`;m#¿}t}ⳟch5?OYד/<ghho}43Px{? 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BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDr%/ %/, WUUWUUUUUUUUUUUUUUUUUUUUU_ **** O@ ZU USZU:5TUTRUTTU֪ IT*TU$! RTOijT*UMju]UIkK/UO֪WZIu]UIkK֪BUT֩?UN! i֪BUT֩?UN! iZ__ZU ֪RjWURB_ZU USZU:5iPj'֪uU$!//USU֪RjWURB֗ZU ֪RjWURBZA$DD""$DH "B""$"DH!"DDDIH "$HDDI"DHDB""D@$"DDDHAH "B""$"DHDB""D@$"DDDIDDH&WWtWfW #?D"#=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???MM$??FLF1@?ƿ?ƿ?ƿ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5}PNG  IHDRcDIDATx{t՝?vK[o[–d`Y8B`O<B+MHlHlD`i!Ba4-Ϲauwq~\;5J tBH)R}Q{xh,H"CzA,'S%kB1fxȡPxj+Rrq<ҋR4=3:P"ϸPWiROC!L3i+4]ǃakj ;+e$R_}<'U2Ri(7'mF )BiĬ31Jؾx($e&1M4\ݐR,Q&}naBY1-ۮM ;?ka$1$ҒCߦX,sv=nD)`;ΑXHT>KD2aHILToκRzm Lɜ#pYFpb ێ&;GuJšBnS -#e]=@vāZGq*r .?g0'ݜawk`8:tntSFH,GwU}<KT+EONl_T*E"`pp^<VJZCy}#̈́j4VWjnX{e0pɑQcß'Ͼ1}Q]]iB! }}}p%0 T{pFgN3!6) \r&֠0,7K  .pEwvιnmCً֤#f51j`ꭀ` pJE =4fdֹs(//gٲe^շ9ۙ.P|BNfIkWmF -S%P@!vrwSGƴ8w?O&_z.w}>C2܄K%V,(kB8 d0%3.ԔqlK.;[X(:sU QpqY6OV\.M\ 4\>n`BIMULncQ# dU PV"=miѲ2*}>f07dBDQgUB=vT؎>d lt%&s_B$%:XO, f&gK<+ۮ%::D8ł97[+ZA"apF=}@j+EJq\q syX"AzPCO.0gek2ִi\w s9!OҫO\|bM|3:UՎeG*LXt5T̪,Ҙb!֭[QJQ[[ ;x 8L?SyhD2f9(}wVXA2.tvv9}0b,0犖,cgB7pPe:.[cO/(yښa j1Vi5ÖcQ[[˷5wňqɨ1Yxs4b߮W)?IWW'0e;]/#]7Xv '3`#ʕ+bS|[ɤ3A4ƕY0n?F`Gi $2%<ACCۗy8y2sY]"i"m9Ai`lD+jkk׾6v^oo'D>_$NqJ͛g/C.1#Ʊc?gh(BGG#ݏSUUž}Giyᅱbǎ}Ӓ9.XH|x6mĩSpC;--:4u o|=K.68)/Jن*@ی g/)oz [ vήb]󻲪[/@GE4% 0Ias79w\֤Y(z`3d|gB+Zs @dtPWWǧ?< T|Bf{|g yFȂ<7|ӝ_lp:z*/~)kiiC7ޔ=gOzMXb```zo|455QVVFyy9RJkdhhF700@T qUWrJ.@wDž|>jjjXd O0d%+ɅinhG U=Iq5kk㞷qF>\x7*ǐ2|WSQV*'~>e{ٵ+smCqa~ӟZ䢇Įelh! /Zt޿?۷o^kɤ~y'JR,tW"Pʘ]FWfyj*ʫYzg2O+}s7M6nh00otuE[*ښWM:y"skr\y啎&9p:t|~sᩗ&X@CٵCee|;XzB 4~O.ri/L缸FGB'}{u /hWQ.06uw*wj OO]VVƒ%KTE}Q^z%:ď~lEXѹi #. M/d f㩧>/^駟<;j$Jv˭=3:?e+  җn|c^giJkƋ PS,عs'_gJS~?>/| Y}v>bޒJ`{s3@0]*c=ɓ'xr]]]^ji^~yڧQ34YΝ;y>[nu,Y—]w`ޑ #VT:z/$B&eݻw/ravC=4z++7*yvQiؔ|Pd;6۶mh?`vm"Lc.-V! Ibסh`R}Yw={سgԧؼy3MMM>}|#93u|GQ,45M!*d ֗a\{A$:3g?}ǦMSWٻwﴦ7+lV7dV0Y5qկϛoɫ:y[l)hԹDQk:]~ RvZ:WM8p@ @}}=~ZUUUl޼9or 穮yqJ8 H (m+Wpo˖-!Xr%mmmyXP䩬u 02>}){W*G1SիVaw&bp8TmF8Ȓ@Qyv>g<'^RtB{'p+}H8UW:Ȓ,&9sS]m~`5OWi鈏HkB~о< 3e׌ C S T ̌0'?ro26tU %\UX5;pSu5UZf)V`*0]UTml'q%teH<8YyYp_Q0#HTfFAp!ۣ ܹ 3gW/^<iUrq^RIzWzaY.@y%)a$B.7QDz 2(4J Zg!\XypShPpa1 䱯2@/z0,87݇3CP-,a[yKd>Hň_BPAt"9)aDfyJ1J)a(DfyJ1J)a(DfyJ1J)a(DfyJ1UwU CxL@*Ͻ'bP<f(o%x*2cG 1H "t ŁsP|PVJVW_[Ksº R:IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ W **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iKUSU֪RUN! iK§USUJIU:5֗ZU USZU:5UTjUkTZUTUTjUkTZUT/USUUT֩?UN! iZ_USU֪RjWURBU?ZU_UMjUT꺪֪֗֗BUT֩?UN! iKUSUUT֩?UN! iUS "B""$D!"$HDDI"DHDB""D@$$HDDHAH$HDB""D@$"$"!" D"DD""$DH $HDDHD!"$"!" A"DHDB""D@$D""$DO&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???aa$??`H 1HFp@?8?8?8??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6l0PNG  IHDRc IDATxy|T>$%a ;&VeQ\ݪm?[~ѯmZwU\B5l!@6o3޹3LLB@>L{ιs?s, @fhno=0|C҈i`xTdY&ƙ+ĸ$Ħ"K2,ZnԐ 8#cgp1KIyeMEANo6vjh@5#X,,YY8!جv,+l1eg˶!==̽<|93߫id,nay1ʫ]ٱ/ %!U!AAHՆ,[ٖE{pcs'"2$m^밹zȒLjJ:ǖݟ=K"[Zlqס ɣ|Mh]dTdH쁓}_S^UDQA*jJ6+#PlN;].O#c灯*X~ʫ_4+[Z,' y% !ZlȲgKڌ*KBªg=α:ƼU!VƤvߝ Y_Nw..9v4M5VI)} $ {m:gЬLYQ,K\ȚdfFC+A_ړ ;7 #@ MF v]Kb@M7:tF2wx TVskS^}fKņA$Tp_U4Ci*PyBZ t2CІmZߐ~&{IIHc#_V=Ju=QCf$܊E"kal6N ͉窹BQ^|*qBH0 "Y} I¯ `BB#֝ĚM 11꣦xTՔb ʪoiϾMXZ9-j=44^PVƋu\&xyg$6ŊE[I <~?<5xjIM:$ǧѻ@bIAF vEϪRcSPT/Va&p+UHNMYQRӑ$*m }{g੥!2z#ƕHIy_oUj^h_a+!y}OMas-8\E Cf5E?TU^ՃWPR^>K&ƝHJ|k6n~>sNF^)'}TB)'W"$ZMwt)&7,ퟞcyTCռ(^̓4r`}F8l.{ssX ѧRu]|*/hIz˦JC[*[n"%1:a別0%))/?mal jU7%P 2 MU(w\<(7y+4!8tl$s%'vYDFa4z4ES+/Ej/YBJ4\8},[%[îgгP5UC>T56Dm DFa8lnzUU_gB3>Ӈ9 e&b 00#.^^}GF|LJ[b_ڧOlb]I$ƥ7Ϟc41x@}k4e$A}C5BZ%hƸ I?9*uJe$0(,ރ(5Tc˃$xfh>}͹-?̭?e2z  Q^Uji:}Ӳ2r;%.Bڪt4AR|oR>ɳ` O$; 3V<J.3#ͭ]uj?^ƼWPQ] u5F-}Hv]K<={!OzAXd+${rġ> \rZB2+@奔uJ?ĸB*U5úoZ6G\`/5T4sj*}Sn"IxF'$<驃$ +ĸT\XV;6 [ХoU<Ys$e/>J1)w.Gzߧ8&4>!p)Ljq?9d}LMie—[ZVߠ<-! ̩ C}VJx.Qλ7 ?<քEh(!TdB[1u[Xkq9bq]ї.ZSoC1_hw%FkԤ }t[$ߞsj"YXWqե$!Ʒn}8w $!!+?i=] 64 {mKӦ8O~AGKQQ]J}cu vWs@U8>}b8p8㑐91i S$)lA~=E7+OUqw ,Iq9t a)m }Rx5$| @me\^n_D&eG8^yrYK~1 fڍ(a*tKX=$Iw{].Ma^s0>&NHUUn}^Y]͌3G?Vswk>7^}yૈu'N"֝Agt9t#69]͸GtեX,V2,f&TCA«4 w16'Ձ6n?Me.`[Tk @cmҊBh>ks (aak* A 8)p:b h?vHNNfXU56-&eQϧ)ք֌i(ex,v5R dY5`b띄 ˖-aÆW"Oڶ7z 򨩫A VsCiE!Rqr'uF:ņ Rc*O { SG_}^]]͆ p8ر?Fcjk~E'<8h(5;r2vZs/dn*LϽYPQo׏={ZV4C{q{jk;w~A` Ospt%f̌?0s"믿J_|q;6[XOJطnh&^k[l_k WZNG䢳~ax IAfexDSSX8N@̞t̟?fκu}INv3tZ=RKmVtt0}:+\I0|}%xu+6z}-uхNfhY+;@~A[RZZ 'j޼f h at,YX;yu;kks k֔msx/}RՌ Cgׁgl9~" *v;x8bӦD-a4?4ri 4zkr0"vI!x gGxc!%[Hl;4 Ɛ/bC6'(^Tŋb3h͗F0i54dIYFƟz:hMdQ{z 4xjiԢ 2HzHy:c=FCCbw07x#?'E4Ǿ?HWۍY`*U zmTiPPjAW狏?|<hЏ P5O{MR]{_"aKNLmq3iIAq8KW^Kݐ0"!6͐kMvv69tŋxbRRRCrD$T:E)7B`9PUt,--%??767# En@ GQT֔,yژXW_}ѣ]mJrB9duTɓio\ȳl2nsNGs/5y$Y$&& ZXve#v6Z83ceLϽ’=+搝_wgTͲ9CW]6ɓ48j7,Z믿>:u2fTwi.i9%YҥK[%#<­)9Hk0SY69mGLkW3>fh`{ᅨY8sdfp+>/o<@,]Rꫯ?95Y0fEnƎMTT gE v̌-f9koitRv><,Yij6zi\9IՁ$Q ߽qz(:HHpaF>S~am}QnϋAǤd&eo;1&O]81QM1]qzu5,'FU7ⵎ [ 9@l?y7aA ĉ CII+Iov>0k -a{ FMѮ.&4I7$ !i-Hyg#9O3݉Edy8>FpPUv\Ez8ljGHB_ muϵz@҉Kwv?znZ$"9!\~u)ꎄ+յbXgi۶tӊ@;;)yb4kΚprB O?⢳~GW9uEwBNPx6NJY`AU<33w.X_|>s[nZ%q H)y>^uJ@_ YH-JumyM]HրIƒW~c ԓO[#}ìqfL~f`m:a'OIߪ7o_;8uxaХ:G墋. i&ŦGM`s0; Vd;60*|PA}bXQ5zo7TcZQU/Er}z6wSDdN7]몠z&W?>)×ރ".\TG{0jL=/,! }.WW⏻|!ڢ 'IDAT&!Azt x 7USg;vѣl۶wIuhNI&~}N"[ZlX,6UbX$Ͽ9 3NU +yTتWCc-VUTq|eO&hsnN޽)--%//_"l!z_o ;MSP%Shm-6y% DCqK8ͷ/|@}c-5X,z&Ҩ>yM U2sܢ-k9s&,]>~(ˇ4 Cfh=ڇ4;4MiՀ[o%==ZZTMcF}GI֔ e`,ĸ*70Bߪhg˖-; } \2sU :=zЧOӉjxg:ZZ\4TfuxFV[ |sZ#O\B"akڵc]AS%#R"e$3]صkW&L`ƌ!k::ցRյ?n MƳW34:$ V([Om,\#$?\敕lуJ-(uopmk)-?"3s>Q^qݍ7|CL7vCk׶xKhd?s_-EsصkǏVF'R J~4$TTRr(&>R]UBY Ѩ9Ie6:(,SYYɅ^|M֬уȮZ|᧏’6-l6>r(z!nrŠZ.d Ѓ.}5ըjFEcc=X"[ۿg 9s&qXuEA}s),jߏm@F|!yj@_+C?G݃nƅȭzHJKh3.\dB 7g5]^ow5| 0::a'26s䑛C8a@Fl=Qw_RXmxqz=4zZ˝0|Ɇ2}nvv6k@f͚?O͛u]69쁓q a6mK/zh y?1j/TPQSB=VbI/cFQ~2fM=Ib!랖{ d!>FfSV[&LMNz)x :ǀ='sJPvB P4a#83Fۓ!&5v5|N23F3u3CQ~סoQ/]7mW{/'OfΜ9-Yh˗/駟 &d hx/H|/{}+:{bԐџ8ԕja҈f3Mh1ϼzOo&@cЖko{1oYI4Sn=e S&Rb%ΝLJR8^y݇f| 9e@+USoA^$VގѣGUwwE@HAԎvw:Uaϱ6y*fMly>I~A?Z++uo'YB操/zm\Gys'q(Hc% le0򙧦c@+Z˼qKO7y_s7"kر_Ɏ8[͛7l26nq̙ *p.55MyFvׇiӦuNF9tHCZ`^z)}?O3f /rBcǎYBӄ R΋y\.>W_stHn#/,mZVy'taڴi5ٳg3rH&L@߾}cȑՙ`*:4 BVpW٩A-Xn]n{}61VIW'7yr%= ;w6 [BdY'N^pGzOOq}?=Gdf>ݍށ-\e˂%eNI;ljHĸ{ [vN'vp2U?WIW' ɈSBI-|8a4yw:%iD9q<1N4"iF8Mӈs4yN#b&iD$Ç̌LO63u=H?lnOdffʨȲȉi16ZÌd<ަݞI}e bql?~vF9{4-4:k"_z^C[)Ӣ;Og"ʰA?=A27\8n~EvGOzZ$UzV'vaM5pV IZ#q '3c( . L5EU0-ج3?~O#} Ò'Νfc-HHU*PQ5W;m9q؝mfsv0q g:Z,jgP\X\Xvp=* *EWAMV'eN6v-ح:AI{Ej/iiwSW_I<ݨbFQSqVE?lq,uΙ]Y}R΁`ˮ՝nwU" p హqc-z zQ5?0|gŦj[Yh`[tIcs dLԿj#ι= +v7݅aw͎RTv2=fkH!x V8Fv#́nwL](\4M#7KdLUkz+ٯ N277/}1ϭ.~ d7B!3c.xtʨhT[ȲҊxF<>^Cp;u%ig2LGzwe+.G, XwiUYSs3ݥLPbljn+0gZۜHnKFH(njUIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDa%/ %/$ UUUUUUUUUUUUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@;֪BUT֩?UN! iKUSU֪RUN! i*UijUTJUPTU5O֪uU$!/U?ZU_j'֪uU$!/֗ZU USZU:5֗ZU USZU:5ijT*ZIu]UIkKjT*UMjUT꺪֪֗BkTZUTUO֪WZIu]UIkKZ_jT*ZIu]UIkKjAH $HDDHD"DD""$DH "B""$"DHDB""D@$"D"B""$D!$H$"!" A"DHDB""D@$$HDDHD! "B""$"!" &WWcWfW #d_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???n?7n$??@ J@`Hv~@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7ZO=6D-=}`0'Zt.@BG~}- Gz_QJ}@n)W?Kp@>û+!F:Y$ I0 0x}'.En{;n GkT2rLk[@@nDB-o$!pgAU= $)QM3+|㇞$I!,w^tCG5HRӯ=gAʘskbq+BG7t4Ccژ˛ $/٭(.F}haH̞EF!ngaJ C #|~f=n8o 4ܽҿ(Ƴ{ 0tt]G}ŧ5j^TՋ膆! #CC3T$26wƕ"b %?OڀOmz(9R$5ؾŁ,;󬄵!.\wSCC;&EvXGռ(YRt]GO=dþ+AF ,)`vB8CnK*<ϼۗs;tv~rMb;Tۤ .~+óa|I1^ ų0YTՃ8eEryϗL8&[ξ+x?HHOBt~s-.q WP Fbo#u'ɝˑׅ?(T1aCDy/)_+v,G.P5:Y͊2DAk7?{ΞԾ:Dq S[Eq/WcOq`6uztFϾDqi; i*ټɟ߷I73q؅9-_Ҍq_U͇!_!>B ƨAxs_㾡hgvoϞ4y*z$qѹҶM'[:Ɔ+P-ۗ`͖,HJh >fOg"Imk5A'%*k6@@BCZ)lH|#ەDeM-8; BTVQLn з[?d7/ZyͲ~<:tl Y;<ǔz.w(<I>`:YHrWa*D47X7xx[t-cÎO1ԓݼ'ĴM~~Feۥ# [׎µWkȑ`7z"5Y#@,~ o|_e*E0/GH YRQy$9#(avtn3]B5|8tt$gӚp]I:7-{;:Ɔ+"3r9:n/i:%[AH+3:~ ;]<aHzY{9@BM$=ؽMqv];B|rB쩹hMQѹ9G"F C!p>Ca\uÚYgϮ(* kS`!Yr) S <@v] &e7E˫LKY2My!Ⱥ-/'Gs'X,)YJeQium,aF m$l43:z\ozLCʃ:HyU .q䴘/s-J ZV|}no}ȀmOipv/$5u UlyXE ڏale ?#w04 ]C$&]_ F{xMjck/(~!!3 ?fO)԰r+n܎u)@Y/9gqk )y2 IK ~*L0Tà'w{NBM$ˏ?|3*ۢ>ʎe𳫦/@{CF,z\]lxZK,KpW߿3駼UZa5x\͙So&݆CU'; Y`k*"N%63[ [RbF4wu2A]c7 n`ҳ dIakˉ.G.FlPy;~_a[VlbF54;97ڞ0Cax ֯C֘9C0؊@ p;QdEVXL`ĀsPdqwK.t$I I7w2 ?Y(=R@صw=}3GҵS6#d&"7{趚!}̗=|ffn> zS=А-cvkw딕QWW!(>sy"!dJڸH!`~=Gѽs).Fn\D}F+e& ǐzҿHn' :kħzL\W9Zձ]wШ]һpH97#d<#I c $W?1㠒RY>@'~!)#/aw/ DP7b8Ly1B[êNy;36f`93&{G4ti. 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Y׆7A|ϛ: 7~Z;xcX$I3zN$r.(z+ySR[[߅ 7adcEL:z?'#鑇!K~A5e_&$w Eܛޡ'97o .0d%/cذalذ!;Ţq#+e^x*dm;G9Ewa58]Fͧ0,q=7*dYi|UuCc渫aʨl{9DpMA2?k4>4]5#< DܾX7Te5Ԣ8BiCǎVSB̪o- 'q5i#5XK̡EeYr醕%XSY]G]u= DW>:|!ر1E><~ oUxb9@+faQnQIBBHMW]| /ŜB@|2 13h*+/ %$ǔmş(m݌F.>Qd=:aWÜ43hUmGƊL=dZRDI=@bbOqca+KJJgAk1,5ݍ34)gapt[%$It'6!U[Z|$j[anǠySxmRS~pO$)Sa<ХCV:) -g2Z-h&1({r0k9)sB<67S^qO5S7|VȱCpѭSFxފk W67G (.~NwC}U)ނ;ͼ?g|et]g@ZnRtY(=,ɤweR__5A97%I&5q䑋HINCDZ Y%rY}N ^M2Xztˑ!taL C04n60y"+6]ƷcҰ CG ^|4,M{.GB|M[gv`.,:uR*h?OINlKZj&Sza!n۹[& oZk -d©_0nyvW?3L ]WM|atEνQdYRlB@Ӄt@-wK'[.a(81DWѭ^J7t>d1| 1q֩7,HdYF3VFj)q0"GAja=,',Mӱ8XStƏҟ&%!(GS3h $/tkl\Ns̫6P:YHLgj!N0njKTV4@'YȲLQHb NBMR@Au>;dɏΓsh IΔ& xc%H$T$6{'>~d8=Ǒ`5੩SSB4!=%Z=dv>ɾ NY_8@RЄΖ@0{$_G"N\.*JL9MF^h(44s5> 56ua`>Z0{%ϑ:qzPMAr֚(ev$j ᅆRK?,gufgyZG2(n0h?s( aΑ Cc>3hNS8G7×Qܦ9^G<i.u Jrћ^S/oieHNYwR3ςl'O3/gn&MV\4l7,nM^hUTL=&\z'!9y|,# $;8Kg߅,aĞA`϶fOԤƐ{ eK#:)1N=ebm Ixs )Z<(hP: /_<{>~4dIṔ2P`9 G|/dW)*g`7߲G|i0¿ ^4Y Mq0| ɸI8] VcޮؕBQH'* !̤UvUmivtW?51sU{AT$qIp%L70 ; ZJL3 {REe8%cgѷF>] Wmmˢs{f+Dw2 dܮ$Nl/e[tS d܎D\D\vbT; Zym K|L4 ##3Wk7݋{S5'$ې`f~4t C7{3w]pmqLp!2 `. idU2kBtLLlpt$pCi|㯎PS(ܖ$̞/Os5㫏3 ٧6&pJf7rpHp!P2H%G(=ZO@.+ǫ!|cLR5:/߸]֖D &zOW5AϽ[~2>$dtU[fWzdI!݆ ]CLF74 CG:.]8.:i$[p$(7`]5& g߽?Ҁ챖/|R[v)8l/:=7W9ìNcE|W[ߚ];f&=GO!,_dl4EqPSwUQYSla,aN⤸4CMz>0xY "А.@}!e#JďCitȢ]JgvkT>V}sgi>^[t@cCGBN]JgqCC4}? 04:zvM.l+Xu\ftR ɝC; o1wbIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDn%/ %/+ UUWU_UUUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU ?'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>֪BUT֩?UN! iK(UO֪WZIU:5TUTT*UU?*UBR*J!U%UIB/TiPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWWfW #??"UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???OIAO$??@L?-hQ?@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8PNG  IHDRcIDATxy|Օ￷znK cf3l&`@q&C̰y $3O'82|$3/o2#;0^0xdɲdI}j-uWUKϟvwWNws=\HRؒSSP>ܜʟfy@ A D B 6؞@h+H RTYh̻1R"SH=8ڊ(1v$x1:yvK)B"=1 .$(PN )uj~x gHhKQh?JH`j]fRIx?#tGt5AS"MA@ܦm qqxD;0~,YJ,ǻF@BѴ@l0_*A<]'!%p6 o䁞2 2iy3b;<]>=yh-|!w46mhn>%PoD]+(d 5j],%t5ipMdD q89iyzeoQ@aRk! ߿{ԝC׷++Hdzl^?~$rd8q2'NakSIcalzv::;g!UV,KOv v"?(0]A9tEE|<}'dwp|֭~!~ӯ-<# G#@ ;=qX ~9z%"0](FDlZ޽utwX'Ac%9qg &>Dee%~)zeFzM3g<2yfi62 #3؈f&YL $eU~_bPL]טe6A0a~9Fft񄌟7 )f$I"4N#(/fLD¡\@hzJzV"ػx h4}tRj(4+ a') FgŦrΊiΐ|Ql\9ltHzP0adjA ح} @S[xFBJɿh3u.Gν1sd l!4ZSXɩMk81bW s0 ޽:&NMZ VWA9B:2ضmsJu'twwS__OMM |) ƺ9rGpN4LHXL%LѴmeg` i=(?9syfoikklI,u׺Oց/t ӏߏ6Ep>9p؞YS>1wYt5&\byfۯkkѶ S|4rͻSR2+ng<?%10&D++43I oMh֬hn :;Zu-P 8{};uT-[Ƃ hii!Mc'cR4IP:nJ*lʼnAʌ TUUs1gysٳg999ܹ۽NYVe21gWz4`Hm-+_ =y3w +]Xj<,Xb1߼`ytqao\Sv+Ύ = WCRH^'{1:fM63fG|?p͕_'5ZU(|=uttk.| +w(1ɉak:aj>QX~=x{Ǿ5k I@h#y-X;@*CzX MX05Vr:nbӦM¾m*B f*sya "utOJqI/\egڭLVy|'^ "%Daa!]]x 8@-h,s{t{ʴhj6gG:ݗBAQ|֒lBa~ `H(P-Hfi6q4׮/-ْLy5j9(B[]GqT3=ۮyƏ8*TQոM\V;v4%ġ`@Hל9ϘxFIvA/sn>U'{%NţDc%y6X,ƭQ"(E8؉9O-{l;4.%H DJImmP@t bJ4oOf쿭YK[@l6$4ֲ{nb=R%1(zsUqt<" cH}4H:oD>Ϫ>s@8ծ5ܱcWgYžr5~8]Wٚ_ 3Y*iENv9;mܸW-5\rBy+SGT۝Fo4p63ԯikݘj=}]wK1X(<7ɘ.FSk-;zV{5;oc.$$mM7'*?q]񒢱R՘#+F]1 {)k mNrX kL$)pڱaJÿ?3ruPc1[/>t<ɒ-ڛ;^w|˄ZH_3% ! vghWo3'QD<$;ϊ>;YEMp 0ؓRØ9KGǣjf z|GJδǂp<XD;MxErxX,3MܺDs75N?Ekbt@0sB". 62`GcqDd_؎8gZٙ<"if F2/R1 L¨F(c"ը+4f\X'q/L֥\Z,qhTdP.RJТȱx3'َgm#(쿢?2E4J c[zo!iFT``\iWac#NBB{g+܋E$$%))uzi׮6JƙdPQ}hOKgۭ9uGFJcK&wןt^aDh%͂TjHS'َG+ﰈcшcT%/rRJTTPU=Kth/|2X60Ym|L\΁.HH0fTWzd^cd=[E"jlMckꂇzxt3?z(`BA/se m\?@8҈`VT{):*wRu_kMȈuRwBi)(DR k$37"e3UN6|{uf x84V~*yfip"teq MXm)c{gw;3!dX7gz^05DG 3`Ҝ;! X "czY1-8Y0 !H3B'7:?_0`8FAWw]GGn7F$Ì^0j7ޚ JsQ۞FЕāg%6 8j2@ $BMU-De(HrtSc-{DR^&o0w GhXc;2׮[L4g<4r(fzV՘Qު9R(r ~fvp37y,͈eRFە{"/woό_OV5Zj EH &C#Ǻ&%KsAħ~gu}q!o#9]"k`dEO,m͢b˳ZYIj?.~!e,7ReүH)5?rIB ޔ0CH#Tc- c& f_諁` {s($dZW=RyB3SH< it+Wk:gW~qJPZe(Lx&qV01FWV R-rEnڋ^졔Eҡlt2&`W KA~P٫'SuHX/qu:^ps:wC8p9MOs. *6Yw{:xm̀ /,0y$zJw0"ׅ-l c4[_k k;˜ۓwܼ,wZ' aG3F&h7U4ժ`e%? t{Q[IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ _ **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iTPUT֩?UN! iU?ZU_j'֪uU$!/U?ZU_j'֪uU$!/KUTjUU5OUSHCZ_֗UTjUkTZUT/UO֪WUSZU:5PU5OUSHCZ_UTjUU5OUSHCZ_UT"DDDI"DHDB""D@$$H$"!" AH "B""$A$D $HDDH"DH! "B""$"DHDB""D@$$HDDHAH !&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???g:2g$??Kw 1h<@?????@@@x@x@ ???333333?333333???#~j????333333? 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BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDn%/ %/+ U_ꪪUUUUUUUUUUUUWUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU 'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_i¥֪BUT֩?UN! i*URJ¥USRWZ*U'¥PUT*!T*/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWUWfW #"UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???QQ$??MG<@d<@? ѿ? ѿ? ѿ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12 PNG  IHDRc IDATxy\Uԩt:LHB CpQPqU O*U4\G+~pċ15a 0IHgHwNwUu35uS|NgUוּk-IB"'paK: 7LH9"(Rۤ1 '@ɴ#m&,ic"oGj9Mk2aAϊM hfLd'O& wur\۸'O ҏ@0nɓGP?%<F.Za^̚PyI|A& ;Ϛy.DyI2YSOv\ox6;se!l=6] 3mK2gg2)k9QZ\- 8rC"!aR{/tڅ# J$2O}INuo X6Mض>mO$pRm-jiɶ(IWZ\#!!=׷>F?d[$1`hYqytxSg3Own&%mKxDZ&I n\V\%10rGlyϩ~A@mAƈ窗 nh!@H fnR%ĿWu=ۢ#tjT%61 zEHb`ׁ!ZzY U AHbT=FE $ҵF_j>hhG8Y{E#eH:$#Jk<&P8{>:q=Ks>BuT>[w̒y Qi'|h4j^瞣 ~>w3H{fj*q fƆ"˯nƄG}".>XrUV_,HP5-ٯ";_dɅg}Ẅ́hNCC{/> _޽˗ɓ d5I|ʕ#곹y)#n"'k5OSg]Y hnno{ް444dAsqe>jDoݺ0Z[rJ6JAO\lCQP~?ի3gm&"^%㰽.%hqwlb!ϻꪫ[馛(--[/R&D N}MS+y"O{{M2 NL&r8>.xʕ+S4[o_lٲeDb0c+Jk(͊n&PAl@JikM6q饗z].<466<fʉhш[#,lte~SL!1Ef,_ΓO>C=đ#G.2H(TQYVqZ)3X_NJwM4oΔX9W}J= .2`2կ<#lܸ- H$|;ɶP}/$v^ZcVs;qŋ|fs/_ΤI_>F3̋q3@]mƘPAm匌 s`M/XnݐZx4a *J&k?1AI3+?wxgټy3v[Jk99vq問z%$y:KB]UϢzؾX|ceO]yuֱgϞ O.%̝{}8$TV;:[u"Bf6Sj$#\8tuuquץ@ů}5ѣ޽;F߫6`ޖ3nm)*wԹ~58/ԯ\]Qo?P硣;FꫯK_w4+ߐR*׿5- /ahXO%@7;ikn{lWaFp~҅kTNh#掃ۓe@|ߤP(Ľ`_ReюMc4z`4}Df(ysnҩ7x`p2ҠYC u|fMYSOoښxh"~^c5%^^wvx+c-T:}--6Hј"ƄS0"_Mڪxo̩_[];ވZh;v`8@-'1c ?PZDQz{ty7]@3{X 8)D+p(<~1DZʒbq#D3/fF aw@rI0jm!i~gPYbwqG^Z 0BTU .Ct>۩B7&9ۚ޸  r,M昙Oil烿{dgÆ ZiSה.[oӓ`ݺٸqE2-sCtޘoQ(C> gX38*݇Gͽ-n\rb|>UUU| 6uFnӉi.+7 h{v {gŊ\~yn3;() PYY_u5RD}}Omɑ`ʤQo׮]̟iR:}1}lfΜA4g|3]/,(5Zo^R5;/xZk;;fGQASSx|VJ) hOgXq +pm :iY\0 vx#S"N"(J$ғmqF|TFUUnzf& @:Un!ɳQUR]ǎQu~(===g?cc XS7Mmg9;/39(P!K駹 c k޼yJ-0T_? O s`]*,,NqasmkI 8~xߖ H=0.ɓ J*Pfk!}!J&RgKؾopć<`h!h=Ƿh$Pǂ!6y!ض'}jX(-2Idi!D[9Q0<ю:NY<_+=1yHWR9td@j|l jP9$%o%르=_܌bܓvgl6K+JR3ZRu\Yww <$`9urlYŘ[ys}#'jEu X`eķ!B{4tDKV Gn5\C-G¸']h;HL=Ƥ w!u=h~s`+zq1&E] )5nk IG?㲘8 c*Ly8_ƭot=a|)|IwIeEM0m)!y0PdΜo&]wϙqkQj`aL$rwK!!RXDGJ˔b5arbPTXPVRl <'?эZ{^d`hayLP^*sXtCroU$Ӹ#bM~ rr#1=7%bT:Niq%Sjpm_?ֆPQx'­JOs,ᴁ[8p;઱>^39jt]W36P u-1g͜Pp]bjKv_S9_'($/4⊂)*? z Yd#A{` Z~uzQ_csLRvN޾X~SaN^*L%ݤ=>]F gO E{U R("(B"_;5˯tGb  J*8x}[ fXe A pb%)ڗJ¸u\xWХFWwMi $į )., X>BMVhu,h7>$wNrМO_LCLHaUYU]Ly.y>Uĵ^4=%H$z%z{P/_KPWQRTz+lE:c[!̐ E!BB#N,etm{^>ct@UU*+jǯ TUԡ뒢RNDiyă(1c]sG1ahgSQ6]אHzQT]jsm? (.*gδżk|ik)׿2 $ǀp#Tݷ#%L(߈q&%6bϩIW4D{0_D/J߳S{7(*>e^4齠YK$D/x@_p:Mci#h}hr$„`O^DW4d _'oJIì(QtPIDɄ=趗h+ ۈ7hzi.Բ`Sg:L{@ŅL4+r> =o3|!}RN˰&^匠Onuy= ]k~3#05  FXwJ3(> vPP s},ݓrs"v5uKe#svvfڑ:XCKa/N!7ou̖<`\,*Q̊˺3Tg( a2Jl@Y<@&МO3stOK_~f0;6/ZIDATYu]gSt )̘E>;R-hLYZ <mMx"f#=)ST9a?e<IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ UU **** ??UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/ UO֪W*'֪uU$!/KUTjUU5OUSHCZ_֗UTjUkTZUT/UO֪WUSZU:5PU5OUSHCZ_UTjUU5OUSHCZ_UT"DDDI"DHDB""D@$$H$"!" AH "B""$A$D $HDDH"DH! "B""$"DHDB""D@$$HDDHAH !&W #??UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???Z{Z$??>>=8@?@/?@/?@/??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13)PNG  IHDRc IDATxy|TL=,) H UVK?ZZ.jimmGYT||\qaE6Cld{sL2 0a>yMv||+I!L#%)tiĦ+cX$ߋߊ0 P_x]no@hRJ4"LC"Wʶ=Fkphti0X4Xm\d[2n^Fw^}l2333l2~ݏ4 $4/P/ί~|&qy[j=HGW?x$~݇n!X[!h+g@o%99dW =bH1 G7|! {4 @Q( G2c~8.u e<1#XdHB!Є"Q<$o:pdoX& .=]eE7|(RrNN $3H<@(FBXDGl߽D/c7t`2Rͭu?~^C{B_/A^he*EuFܡ*|j1>ΚrχvnnԄ/J]xnGB࣏> ?#>&}"i? }^|~?|G ￟+VD&iAX1#:8lGAJt]7I)fcH_/'9;7߰zjp̘CmPg0]?0)s&x^^M7Ѐ͚0 5ן{9n^ӎ ' B1w\6mD~~>%%%| Ιt) ͨaic7kA2gǮ!Op< Je;Xu)**R41|pFɫo= @a FMRe@D0 Ha̰(SƇ_SY7FeGsᩧ`TVVeկtԑfe)j"w.8s^6y/4Heee_W{.]g7opژ&Q S 3ઁ=>H$⸑<2KYb7tSyfMUe:K@vU@bPs5)7E-SsL#3=>^DWGu _[>|8#F୷b4W$9) MwM4vXyd5o72fِ:i42r`]BM}%݁JL4 ͛ytggzL#3-vv~I#@$ %W?Dh3o=ي 4ԣ Bhhᕂny<ӦMS7{}f-Mhjj2_$;OunE@H#g #%gb^a C/a"a* yNF9wKEE3gzS.W]u/n56j27W?@%ge?]vT@*zmm-Lȋ@tH bx;!׫k76"i3eS۰/ ƾ@}@(Z)Bv#8mE\;ۥk:W}(ruDžK/KV\ɐ?&Lzx"W_/ͧzw5ŒrH$k̑Icfj'^'ٕv|g͚5L04ϛ7_| >SZZK/jea.%5v>ud0yQ?˭-JDFl6%}FB*C@b<rnjrFP^L ._~(~y'4M!E^|Ekߗf<Ý '`Kvt|9厈4S]B YV_w"N%ϋK/孷r'On+x|ܹ/yynY-AiA=DJPZGG%/9mkr2 l`B g H@{08˗/7#u:O?4cǎ+`,€M ͇BPюPTJC*ԩGM]I#kגg?pY7յd^}U^}AFXooMcҤIf%0D2n#zr3 +eUHCae;!-5Qsh/jwG%3:WwZn$OpkƲepBXgÚ+{%+LtaӨc!q֓Q`s:qy;VO^wHDf'Af9B7I"Pw#o싩SÎ#} ֯_?-S݁+o@Vz2ȓx-H3x6@p]eZޭ0&ǪQ89=z4w ?aص3"%)=\6溿Ng1dT6GH /K 0t3{l)S_lNu:I?92-%K$gdW{E#r`(9dG%X2.]ʢExɧ,vOu}ܐGs ⑨R?.ѣG3w\{ߪUxgM#d S~D?um" t$!VM'VL27xk|<q]٧()StU"pX!S\=J6K4[b׮] 0_״~z>xCmyS?4h xFWmlR݄%.8 tǏ_Ⱦ;3'xBCpVRqHWh#n8xHՓ,$$OG8o``O]O<wy'Ƙn4{TwO ڸ9[~M"2OVm5dt>}4?5oyU4Y'\B lm)tP>ʊ Ry`+uؖ2x^Y2}]N[kGz JqFÆөQVև^'X \Ƭ+pZ vڞiOIC]G(Sf6Y@Ա>%_~ A%{y|r6>h!t`(PQEa!yn49|~o]VyYӾ gę>6t{޼y|UhF dRG=`HdYe)iU_\~?wK]`nN;Mi@C֑LCD' ?[ x[u(S?jl &0h fXIi`9q"qE`T W?d/+ke (A+9 P{Bꨬ$e˖{ir`K%P[";LE iJ]G7t[Bqt^~eRSS5kVر`5a`dz_aj] p^߃O+¸[bŊ}W_}5?K\p(GPt".W=umkPtSuzK}G6lXN0i҄D\u!3Dkkk]vjoO:b2|993䘡gaOŝL`lQH ;XRR\3ggOS?s oˢE馛 dW*0<ٲ_$O}9XWIAnaHjfW&`f͂EB1׏l죉c#FO@ )HDy-bʕhX2G' #9uRY2qKP{Xa1GP4 555\ꫀMDJnNYv{c*E0hhX&ꑐm|>+ܝvdP3#q6jQ|c ' HVzBhx|]9.Q\K z;V?E ws. 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BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDn%/ %/+ UUWUUUUUUUꪪU_UUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/TU?ZU_j'֪uU$!/RWRJ¥USRWZ*U'¥PUT*!T*U?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWtWfW #gUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???OO$??%QI-0?z?z?z??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15PNG  IHDRcVIDATxyT՝?nhDe"AE6QѰ}%fTu3Ff4O'M2[&q\snշ~siR T P!.PIu\(k_xg vw3&fΌKA|aLD*EIi`͜ILE![ /n6slX#*/'N߁pH&aC}p-P %:-` ao'8,!@ 8RK! 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Er2ML!p$H$$' `Y}]N#bd}[vSR0Ϣz0t-E>f#{p+ 1'!*_2Y/s^gTXT}!Lck-HS Ae?!egLPo+L,/}cH20p:ebjoRƥJ Qrb iHEMik)A\41hΑ=cnoyiwPs4O&LK{gN"Y@AN8ptSJf1Bq<)|.ݍj(JW1=p}s6^o<:P6\5pIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDn%/ %/+ UWꪯUUU_UUUUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU 'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKKOT*UBBR*U UHBJJ_R?/֪BUT֩?UN! iZ_@Pj'֪uU$!/TUijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWtWfW #!UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???NN$?? PE6:?P?P?P??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17<PNG  IHDRcIDATx}|սgf7OBEwjժV+굽U~h[[OZT   AHByN6;sgfv7ɆM5ٙs~sHӺv<gO=r^iW>%2{ٿRmHioSwF'ĝ<v9Wp¨Ĵm+ytG 7\0-(D LL@k{';:~z jk`6 *@F"lꏈM+>J'#TW* ?VcEq7l_Nv$<] Wɰ ny Ǯa矯x0M`O0>Hl.Bܲ{"Mۮ;DHyS|É(;<_X]m>wks-Ο|5uU9W; QX0i 漳B @wWnPRؿ\)@VՄB$Nyʷw9yJKhǛQ?NQ{ X pUw%gzĕ28?i!pj " Õv½^gNM;J7ۻAQ1! 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Hx,YKkׇ!}_4|Z!pMJHt/qqIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDa%/ %/$ UUUUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU ?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@;֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗ PUIR_Z*UU!RT*U$*UMjUT꺪֪֗BkTZUTUO֪WZIu]UIkKZ_jT*ZIu]UIkKjAH $HDDHD"DD""$DH "B""$"DHDB""D@$"D"B""$D!$H$"!" A"DHDB""D@$$HDDHD! "B""$"!" &WWBWfW #8̋UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???iB:i$??&R7?@ǫ?@ǫ?@ǫ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 197PNG  IHDRc IDATxw|Te̤BRCK{&]wzz]]ꮮ6@PK@(!$f9Sf&3LB |t^aNyΙy-GMhB= 7 4_MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD&MiBD@ƾFAyl[h4^A^ʰ7 c„ Ʋe˖ pc.!& {0v{($/neMzEs(NJ%GcٱقxOzs,iÙ3gxy7ok8L80l)?Bh=9 *To_O'6z"RSui*; ġT2Tdن,ˀ[=Pc{<G~BT$IJp/~wof{>4בWMbơL:3И25pYWv=Y7g&Q9^k{66zm*ZYŲiKB֮Ze˖ֶnJˆYUJڶDXH3_=;A5NS~UP%uEyʪ2秱pl3y+8*N7;ǫK<ʏYIeUU iVN@YLqɏlA!Tld;k~z?-ŗXɼ +0v2y}75UuCϵSVYBJG9[|Z8qf[ĹiӬ?unrhg˦?,#\U8Jc{I7d1eR^Q°~9'eI4Q󌎝GdUS>oɬ<5k~x-V`O9N7~ß_USPU1׮kb[V۞,()+@QtIQu#CŜdžp5/8(z"Q݆QYY8qeGT*J6J%e^Hw{_Xr6-n BeZV^MΝ@ee%~!￯֯:s]:D4~x bG ̛7DVZڸ86z >uR:QU@:_H񥋀Df1f"Zv.Wu SI;_YI\*/$+v v?۝jy/}5o?43k,-Z}@eU jワ @HHqqqٳᩧUݡlvPB\6-+Pl6;w-|l1p\Uget؅,0It90W_}[ۇO 4~ lܸ"@JG9U l6=bQk׮e\x:"#1Ԛ! gt9ܹn/P\čS%,$O7w_<󤦦b裏\;F7DZ~Ӫyd֞K$8!k(1nCiӲ}mڰջlA~hB ѧOO<6/Ųeceys=ɓYWswy$8Msҷ{w}m,6[69-=P^^gpt$8Au$}l}饗xgODD~P <=0`lP{q#} '|­ZφÒi"<-MATMCӳ̟\鶗Hd7鑿*=*zqڷob|Gl߾'N0`똌 6L_%t\?i!!5k_}-:-r7.%KwqҡCbccYv-wq>5kְn:?['ya] '@FHw… }ڰhmEuNr.&SRV@iYe,0,9.$ү( E՜|v;sT11Ob"ќ/Ð6݃?L4³,6j{yT:܂LN 㘰zŁ,Klk= ^UU1Gdluj~=y)pܻsz?c *+#uEzz:~?_WShLm֖R4 D(",$">Qv&T2rN{'1g=gЊ@*}z}?iJ_6`}8]')< ,$H_4P/Ȋ+9uʿq{:vZ#P:V)(a;aG^絎0Kjdd__$In & #H:ņ_A:zjDV]X 44d 石tR5<S93{UVqM7ޢE_?˼pČC NVW-Ƞm΀ 1#c?3?ïW8JG9_םRT3ۘqÝ|_CsUS2i3ů!SuWEQi.Ng%,-#s鬪֬YòeP2n=]+ gqOW_}_}D5+6J.:z?L*"[Qb< A܀Y3K7 '58АgjQ_w}$In aJG9EgS^Y°iFd#Ԯ7:YhKYH{/S˞x>aZ75p@+vLYE~ҫ 4M 迃04:ȱ{Y=:n었{}ۧW<K\4QC"BAV SRObaVs=P(,@ypxw> -Zc [Y*B{pLv[`5]v'C"}&*ga!)-g%jٚ {,_OCHĝLyϙU$Ieyv&<,ɨ )-+3o_0(REq< #'J'b^zwjE*}n !B*.n *7FB9xM=g~3h6ɻ4bN$YF2 6ㆻ/fp =u8+tS(KeoosR#{!Hڵ8byݛxثW趃!1CR#=n лP4RV^ąs—h֬gҎÞ&vOpV^SP5z\C T4jjqc$:Y%9Dt4P7^ᗮdw{6#Ѭ-6Ɇ\R+ё-#{[ #K6d {"M̀/ѼysN&}΅jCUa޴L'a*gN>\_#qLHi/a7jo8+yfNdNM5LzQ-n)l6نSX|)d?Mz r./@y炗CGN 8pՋtwFα,QF\>iN ~I8~\XyOsli}˖a ZzSBZZoiHclȲ,rO!0’fR|)'l;{]wt܍M7zR@H5aPkz⩏ _o{{Vl6; E}1=]yGJqm=aΥ6~MiӆΛ6Fr z켛[2KC(*ͥwd$! rSyKpiۺ'~{}p{OU.9,@ysK׫?S5`TC>p,-Ky~(6o>jSLO>رϝOVVɐYV,L2I!I2l&5!#3EdRm=),cQjUUѵT'DrHU!7z? x=kqi)--a%n'1 9'9~̣A:aBoƌ7SU;H-[;&&Nǽy'7-[e٪C~S0aGtoA+"=eoEsp ˣ!h*NC͡8PT &9)Gv8W5HȊ?m/**ʳ2cHĩ ;wy,YByy9񮙞f ]ɆM|'NU/s}1ou$RP$@`:ҳ<37H:[l]}h9RVTH8cύUSٴC?˞={-,X )dY/mۂeO[_ٍigJU,-8 Zpl\;KhTe0K9@ &z_ox5ug"Do>(5/J 77/-` !+(<3<ȤIαtbi{C)Po!,rШ9OisTPJ'n7 j΁23ϐ@ݵ0So| 6m˖-c°eȗm6F?f׮]{; XOݳS^q,qINTCnDy3jrn&^\O"җ M{rԛ@͛u1 %8(0]o> nͪXukT0J H=wk}srϢ]"]:DcE%k,w{5-~sl!qrO[Lbhْw^}5F1L}5{HJ򖋙9.+G@Z˦=ӛ=\ -tFy]HĽvt܅D"c\Eׯwi[+ٌ8Nk]DskkڶDe `YKA?\@DOL 29 kr|oRS=22\ݦjby CnvXiݳ=}qt]b4q޺$615;.$ҹ}t8\*+49zNL6T_<{4$INocB+%rt{u!Ʌ$P@p<&r3TU_SC=]sDxϫ~).suV+a4/R2r:vᰔ3S2j*fv0ML}hlnCsү_?Ƽ=#g_Z鴒$_%,!ȼ~X^OjwZ Њ7PUEQ C6$-+B^˫ч}&ҜP=%k$+#p,_Pb׳~z^~ᶽPfG5w,dl7ٰ%{,PU^R?hʥoaOj(FiyAy 6l rݹjpcxi=[cV |kM]mhժq4MO ];{7l:XҜP!كٴC:Dtp6{th;lz Ĕ[zl u?n܍)ti߇un Iw2%Wl ~ ! Ut ;=HŨعVSuX%@Չ4$0NKGX'ĔQ˹x17oFHH};CTK1CO67n#5-~%d>YK-svѥC4׷rh'e0.V_Q1b1SiŁSBQ|no-ŋ5KMXṀcja6k,5wٔw1<{60sv'[lcZJޘظc>w>wMU$scs1 Կfk9T>gƌr'yup8k1!}'[O=\ԇ]q{9pEUU 71k.0!unkcЄƶCMqGNHp8,[rѬёzVYqLQ I\IbxLlZN#/dT\kϙ3 p5yEM1v-Z#+xIDAT`ΦChQ|)mj_ʥoXwϱolK_ֱf"pЌ͸N4J;(:=ny kT2a!O#,uT\>^B@Sx$=: x| dm,B?qh >iNK YXK=vΑ$K I@ϓZ[}\ת u0Q݆ixEuT85?耊LGTaƿc?k,6n(f=sf#r!Č#ټE3mA/f\^ IԬc(|/E,eE G~SqL:Ae$$Y2fX,Ol}G܄j8;+rV2%f 5@f@+ӟjOm h6 LbU!(,9omo*?Zw!POmz٫m V!IZc&<$z &Ծ2Ek5~p^.v~+K=HHLy #lԨ?Ǐ[q=rg܈=xSVE9B"{P[~ga\/fî 땧|s]NX@!#;g];ӷo&yv  Y5 j $17ͷ{z&+@o:RCrjߺtf'-RJ k&YUʨ%e:4aZ`lz H:UJr KrH;䝖f6 HLZ0qw2a=i{T{'zw64]uw!ͳV SciAFՈN ^`,T/:q2L";ۖ%IQT'_Hl4 4ǓDn¤+jn;xGyG`@'6l˹x!~;d!CT kBװWŀ^c-Qndx΀>׍[/^"è\F:7gw_\ ,E3jlo' C 8Mh"NxhG z\OoZʛo۝GZt+l.gbmѣ@FIhHs$p%'\ާN=s[>{)wsN fa-Y[2\̞lJiY>׷nGw9wtno=vM'<$IUp<'#Am,<| ]Y0!#B(r Β[pmѹ]jһz@2mF(juRKEOat0 ՚P),o8N{[.>WfX8v3-fЇVY~ ZFנyθ%J2uj$IƢjN:3L $I = ıaq#Job°eHDYwuf6ݬ'E]z桤?`n 8vf+ߩ\f@A^ת `@18*>X!ϔ~ 9s1t ё48B%s !Il޼{7t@#αT>ڵC  !ѵc_Vm 4u(w,K_Sj| 4 A+NeC2PL `pDJkYѧ#a-'i6W"hoH8Dr]OE]s;UorZǘi6(Ҳ"bk,?4 }M빮UGBs T#[",K35`.i~H8LY}yUur a# RFa 4A!zFx:&}G u;鍊nbժUmNGgD]OkFG'>in|(M$4 iZ Qe]źCu0cticI}f,iv4UEH6q_uq73%52foZHmN+Y$Ӫgϯ\fƊP$ՠ'</ NHwuF%1j*Τo8rKެ&N$4TU! nJ$T׏1!Mߔ$I27^ŀj¥":MˎK^XM2SP^QLYE1*T^uW )G9cfw,OF%ONuO!S>V.i8`Mt} {X҄j)HOiSROIY>ŗ.RXrl++HHɳ\mdBpӌgF̣e0M'*0n+~B9Bʃ4mjVX=?n>>US))/0hj5W)Gt4K j wknWj0Wy]6s6Եь'xF*GzBuizDݍɁ䐪p>_jh0ȕPpv;ckBe䇯)6uƓzJwY#+[?pEu]Fk@1>5#4̱m iEui5Gq7{6'~0oPk55S3 Z{?ћ>[yEk +zFY/Vd$W.p[Z;aN3V6Sr=g e>#Qu?4vڣP3T/ٹɤegP^W$kVo\LR2qҚK Oکikq6}{Dwǜ5\p%bgZ>iOciRNgn7r m\1q:mU'ړݱOO8ݞ 8uYj`҈HٜKg< w+5eo֚|u9ȾuzI`Z!ˑ$dr9k}Ξ?U_<3J+Eq0,f:R0og ^  䥐O7 X6ː_%-+,RE-jG !} `8pu碨Un9> EV5 f0ֺalҒiO۸2)_'Kv(˂͋] _"󂾖Vm˅S Bhd;N;ZRPs܍%$tjW3^#GNo!h.hXĬC!N dhl Sms_ b [T ˖ /KXVB^挻 >rGOFB͗M ÖQZ^hHÎ--KrU3}%ȻWPR#j`BMo`4)r9LlXxe]pyxb _\B cta$Nev'f$KR顒j ~ǓW6eo燽4j r<[TM{ W*YS᫐U$!#ij" Q qs4Bh9{̣thɠIF+=%N)ȽF!=uԭ$=>us Rmٖܕy:p*(p%ErYѥCOvRu\c aDƑy}&[0g=:4ٱ ܅3~Ͽ2u[&*^Ϝm2Bh hU_(bh( DBB< sMQ1u 3kcf"UD.ti*[lD =NuXvUstqSGd{Ak9}lAl֓] DQiI:q:+rVPYUVp %),9Sup}HV3jՉC"5+ӟf/:ٖwB&4sҶUgΤR;WDYN̵ h%eDT*pTnfL{gNg%UWT5zu 4kooЄFuNz!3T^dZ:?ޏn5J=ICy8 dTU~^}'/Uӈ7֏pO}!4^٘0R(,q/|˜GT9/ ᧿xg#jO^>i|ɒɻiתW2QRVYbN9h֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKJUTjUU5OUSHCZ_*UB*R) UOJU_jT BUR!RTOKUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWtWfW #?B1UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???N`XN$??`k5#K=?ÿ?ÿ?ÿ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 20 PNG  IHDRcIDATxy|T߿ %HM6Adؤ B{Z V[-l}\{}ks_.T/]pqc=IHL9w8d$390o^C6=3]>BJ-DJioRGJ)ԑֶ~'-mbD>g6l) / GZ?]D!@"@J@ cBv0~_t*1H)h,RNk~)!o冗AHaCA `(&. )Ϻch 3Ũ3-;_Ɠ-n殘c{k{fųhյ%(Bᒇk^-<:mc .?G[x4a(1"/HvpDݧox?{n3v(‹lDqlcxonǷ%_(\` 5OVY`;n[è}5ʫ?G a_(_eso;q^PC.v}uޖn:zyaWMP]G5t]C(J}K;.vb!i5kߞ~SmہnUCWI;ppAm}l뎛uͬ Lq"T4khRC"hnxmf\ڂs&T_J-h WSv\j1_'OG%}˓R_S9stYT-fEy>ӥNi՞>/}8ן?x69yF"0B{ѥf;#cmYSG;L7gP[#ͭ~M^B7_.i- +;2uJN(ZxYc5u#U&u,.;T]ӈm@t M<\^d>{nR^$%o681@[Ee|QyŒH!% b:N:1RU=M)\pU'95úUgW9rlGyVcgQN_S[Q [dii|׎ij1vC@TclIoc^{BfͰxS#'dz8Q 8PaBlI`C T5%xKBK%̦xR#k2JO5u8-M.3|pIA 0 ‰%fi1/݅I3--T}yaB{xKRmNcXFAmCŖsV!fv%m^ E  34=Qb%G不HW)ZhF Q^UƝ5{N`R$9^͏!-$cu4́`k$jh3Q}Fb{"ws^|hI_D(D :tsx͋0X5*&iLgWH'Aܲ>ё=4OT*f`KP@vz$7/,fCSk KI,ʇ:fofp`KOX{jk,aC_u,5}"~.=;jOtXy? 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BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDn%/ %/+ WUWꪯUUUUUUUUUUUUUUUUUTUUUUTUUUUUPUUUUUTUUUUUUUUUUU@UUUUUQUUUUUEUUUUUUUUUUUUUU ?'UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU>֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗JUTjUkTZUTTUTRUTTUUTJT*TU$! ¥RijT*UMjUT꺪֗U?ZU_UMjUT꺪֗U?"$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWUWfW #!UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???PP$??`=KW0?a?a?a??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 22PNG  IHDRcXIDATx{ՙS=3==7AEQ4n,"ALV &1Y(jq]QbY^6+QQ4Q>=Uzn 3ؿows"RʯBۘGϺ!@)9xr !@9xrJI N\ pAZ8h|S![9ϓS7Z4`#'Np%beHR<9%k$bQ siќN0,@Ȋ[Qx|^x}C`+. Ëkޱ_}yϽY連=!(%}G yI9U8A3BnBBuz<33 J! ! JF+_;o_s rꇼNҢGJT6RHea(q$)7ya-<JSmFJ $X+Ƥ9sK_e%_$m;F5i%HkmyCHgMJKSְHi&i4<= *yl'QRS-FZ Dh4P}ru5JF/B:Œ6wiԱWŎSP7*B%a`mDc 56yYAZq+Fmg|~m'#QX -ĭ6b(@wg8'#m9RO,J[)mOZn:~n#rJVm&B1j?*Oh(q )% &BÃy^lM% 9e?v  ()JIx0E2¡R<f0gUn4mH ǔW,pA)P) 0F{6^9F2  W3j*@"¡R¡ CcL#io ]9xc *_ո'0 v@0Aj>kjk[ 0yarI+wn}} =z0{63xp!Z8ϳl2>jro?SYYٳ3g/5/rΝK$+W &)2$L `P]b`50z|LUOOyw}2z+9;s 2e @ !aqIWEE'Oӝ^xoΕua6?|tu:[|I֭yPҖĭmlj[m(hK9Kwcg<ϧ)%#F`̘1B!~:Ws뭷<:u*ƍO:fݺuL>|b1Z[[yٿ? ~}i.XxFNॷ~:yգ_G$owx#'FE=6e< s-l+C4ϚESSX/{&L`ҤIL4GuY7[nsN<٫O2w'.@xqf[=Մ :u*Ǐ%KhjjbD"u>=r"eYU/_NUU? sOPBxhqE:)h[J)%W$Eٳ1cmgUULرc7o֭4<ԋ<>5(hjnxƏϤIB)Ν;mR5o<ƌ?--.?)ќ/V@R0r}!@Jɮ]mAB)6bDc-46CXRz5=ϡ/O?{fafix8%!^6{/@%kt'mt#<8p1|uY@Y -܅Rߤ1Wo*'Qe?<=,YWQ6~7͖L'tg{eÅF$ףy/;퀧=Bad'<~,+[2 >h4z;ۘq{ިijPl06R`>́HgݍЉ+ƯzaajP D0 $~``Ϫ23_cFM{"  Aw;4M0]s?y꩞$]UN40M=asNpm{tjm&PiR!|+(^ @/sR#N=WlXꍳi窯އTCHC"p& RQ72i =pr J:y"AF"iq2e+p:* PYDIJ0t¡2~@b91.躐W=/]pRbϷ٦RcHa2 ˲>>qGoTvS4*9ҽ[ K'u (<.4~yHtۋ666QΌIt*G.Om˕J܍z  K7zTH4\Jʋ\@9Ŗ>?}SxN nj3h)B  b?V+`&v8C&9ٲ/gVƖW$~PbEܿs7ʄDYpRH7'La$^|I_ 9l/ItcWӢS/hW$Rk*)}?t6BƎ>vM/\z,3M!#uN+תm鏯=&^ ϱGдɺލW%Ӧy31t%V {/wWIz^8t P63WRv/;akf-<;wS$)HJ^wʯ`A#u5Pn "A+VZT1H*YqNur||:xHoM)HЯ1<:@ ΂3|h THeN [fBtG1Og+m~A||ej+FD..")qc 8G㶞y/hFs#`Ϊ2.4$r9]xDB;vv;գ'um DzoqgpذctWQ!ru(O&tx/6[ N\z^FVwR?,&U֖֕5FuyF5|CI!Vp;-xMTBPPR_ņ~ns3B0d38ͼ0q,C5T' μK7D"DE0JfԤ"iWǪSθGVz-:/ O Mf>L{?vҕD$efyQCH?AotDv-22BYc4c 9S@~uu`@n[]W,e#\vfAmW]n!z`~<;vRږF3W.8nJJdA(/Xan_=?e$梓0rnsy/H߉p| 4L ),(II3B|JlзSݹ!$`z0Zvx,J$su.@I#aw~~/4șCF 10 m6hؙn{z_dJ%FptLcNB۶:k( VT鶥G:f43Gi?LƧLb|hթ n!zh;V`o62V4n[z$9g/}w^sNqg"%8(QbMDP2VaG%3ra? g(O%Og44sH1+r& R"ff8;w3[&ЏM/xp8:bUF= Dl2IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ W **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iiTPUT֩?UN! iKUSUUT֩?UN! iUS "B""$D!"$HDDI"DHDB""D@$$HDDHAH$HDB""D@$"$"!" D"DD""$DH $HDDHD!"$"!" A"DHDB""D@$D""$DO&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???ii$??9#Ā;? 9? 9? 9??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 23[8PNG  IHDRc IDATxw|\ՙ)QeYظnX Ɣ%@M!d&y%loBL-`c\1d[[ǹs5fɖl|3g4ys+׮7t0|4r2jEyo#2Rsc%Ƨ;So"_-'ҜvtY3A +ThԠA򳆠.4UCQT^o.{5悰Wm:+m BX )<ƦAUU@A@0eԒ^~w,RY1WPk&LYE epո5O,yؑE+)!28\چ R8zz7 B' Ϝ7{N}S e9ׄ]ף^e)P\#?!B:!jBOGOjrobKˢ)Pas9rjWeXIR|*p3$P;2F2SgaX: MUL#> ՟KuS^u'_vҽغweaY0Lcwd{u# 46P^y=QQSg!ż)c٬u(:ʈ̛rE ,u.yZ{U?z;t6#'$;tcZazųxe#6ˋϛU,aZiɹ4z&OB|*e`Z:IBMB44Vqt3vՋ/GQ4z[v㤧a:&7c0o9XIH4 yhQY{4 1-@` ۇxLu}y"`!=9GzփLK> 5j=xqWӺ "bM :6L,-,iЯ\":,2S pi}~y_ T$ڶwh^P\+p?CsprLD>HGGՈ@UT\ĥ+QJ%ՍBE}]o$8|b; 5=W}U`\T g%IBbFj [TȜzQ߯\bka0Aa= PCH}, ,EU2^.GpT EOTM  XZiR]DV|^=eeD)&:~ 0R(f,y`m)dj!V[<[_.S(R(ґ̑<۾'wcR:6thHg#Ts<2:3Jz]h UQ%a9G,8T_UUE#Fakj?.JD*'2(bdьnVH#'?F96]An`\aB<)IYhh/ߋ2&BX4ՃqKeIX²gG>Z2-OK)%PUMF_a:cd@S5\Msc:;-#SуgvyAycT M4.Սe(W1MI#RA\2f,ː*TU$T44EMY[Jθ]O-Ü8Ķ}oQ2԰~\l,e0€pa:i`:_qΡ' 4^jB =&aN o)RUu<("Ic0s0}ߖ]ޖ2GO}"Ð銒4rN@ ^PUwi臱s&j:|c{-1~ so#;wd޼yؼ˿BK 7Sk/1Fa>e1a<s'߈㣱ƦjэO/Uբ0A:CF_2>o"]Au^mj+e28QW|k۩i'O`Dt\.iilz*kN^BlѺܲ<g.t#D}c M5TՕpwsS|9BX^'y '},Z+ktq$i꼵~'y +m !=H}cem?E4LS>e791UQ] T֜9 FaY:l)S` P.ތjG`AX0- r0 L  Ks)H((-g<'#ٿL{ybw~?O?4iii?\oΚ=III ?*l'h0qMa(LEP#,TK;4 u` (l}=3DPYz=ydVZŁGCSUw7nN5=90QUUQQWC~>o"q~|NfvXX ]F!P!KF&sd _T=ٱq=qqq/Ê+xWE(v!BJq9ށa=-cJpx<!Y\'3u׷M⓱m۶k`0g222(//ĉ\;!Ku7qxTEôt,Z>WXrnjD' 9Кn|@ƫFkۍ> 7Mj @aƸ ˋjT,z[bV9uM3#Ϡ⩩;kjX MRs}9z-vۮ]֕qVJlb8l% mE !]>Rﻯ= ΊjT1iRkēO3AO0AwsM:Uu]1c^Z"՟#9"-9WLsElnySo }^,ExƗ>YOB/bY̜98JJ*L_v2j#fmƂ x뭷Zn^ǥq&Ƴek\E0l?c?Ip39͛rgWQ\QGyGyٳpcbڎ,~}݀\Z:|?꼬/ $z&@0li(zN̛|#5'9ugӇ91ыaaYӔ[f^,|޼1R? MwuJt`v8#fē!˕bƍ% a#ٔ< b ;rKxTiFk/hiw& 86n(rp|alih6i"ΔQ LF 4lt$ΓLn`F swu'Z#ĉ\'w06L8(ytJHvZ!At=D( s'dΔ̝%?*3ph 撺ekp8;rjHaAfܐX%m/^L]]G䚚\.6h5ymK wm%b;㮺]vmQGyvEͶ̚p-* 0CMrKظ}-1+" /j`ɏWhR^un,,'TƴLt;[o}Rh!IIBQT{-D?qxumtoV@`L$df:MsvW6ME3HXQ@DZ9:K'֭GkwL <_c%V2e =\]v-?gS2s9A/qXS2 e: (4=OI"j4i9 1c?Q: **BO!>b2V̨hUue$Ƨ-O=7…q.-_tq&NȱN@_,[W_}sS$ŧ>HW9}~+t#䤮oyGP3©@%\;4c3Ol7å;8rj\~]3~K/"bZpIvT5kHB+ʸ,SC2A}ߏ7q? M7U]t]"Ws=v=^+o'G s=ǭʳ>x;wB̵_~]@uEUm|\D駟f_T֭[Ӯ \n'j$Z|{46ל_㒟3㩧f\+L[.fMJ̘TLP?aK,iw{R<_qIbĈ"@K.(WjWX!&y/|g GQ4U%Od P]]ݦϺuXmw9Ě5߼\yIvf@TxmK kHʞhQ`t6)!@}:y={b]FO!x=>PV@]|:e l֘mni29(U?C $ϤlGKvѷaΝx_{mB֭ 9GЍPL=dDԓs}۶mwv?|6OWtaGv *PU{<X00g1hb̐AHsĘȪCREQHMD\=³)8SEQPU_a9s0|m,Z7<i=g6yJUy`lDX3(wT,"2HDG^Y`BEQQpBsixAk}KTT*L+d ߾[~3ZeU"R V2K;6?6S{OclٲKm ^X0 I4a|& 9Gώ?$M@8XPQX}-|>"}`'w~]/ \@PP!a`/:BT@}Dž̢qB\"l̩e^71v\m8E(6f){J^QSJeI ҉{VcXb'DChjΌx^JJd w=rIуgM$nrXf}׶ SQ=Z~y}wPZZK/H|0V d(s4jgVD-kU Àa'碛aјEceAYa2`"v%|)s-,Ls7?`ʔ_t\<@blv518LcH9nhw瑩;vظAq"jhnGyn)ET@ /v 7'aY*J%,;}G:ӓ]1~$]Aqׯ_mC=?ya)MWo:؎ƥawυ%8QღdW;U)3fݺya־ibCaɄ 'nh"" [+zx8~UUYۼ]A8 Ge D;JcX$'zq!Ӿ[=/~L#q+V'O4F NRB*X rz| "mlLGf 协tWZI9-7:a#xI#!(-ۇ ܶM@0~\E֔zGY?NK|K>[L3Q44nrve`HH 1-:y BAAQ5 1}UlF´qsl01^*t㎓UDJEg]O`DtUI~Gu;[M((F~PEeel&FM0M,` V7#sݧgي&@e9~/!Tv^Zc͐Kvc(Ӈe;ͻ_eΤ9;A( ޽ؽ4{%Oy<84UNUiR] 0@Q8 sGlݯ;mvy<9-gkD%F0gJݱ!@/Q1XrQ\2. nv6i].Y<:h@;yMX..̓\\=e{ټU'\ǡ펫c1mE"D&O )]QS)BS]o"GOBQT2RM90- Sv/391Cf;}"Y;(x\lH)+ ^)mkd0dKr[3{Ŕi6G7BkLxٞl M?ǑOhc$32'dp'97G şŦcS 86Np8 ۡfx)H0y" Td#?taCV,!7',cvU5 B =30g$كuvϛ&AM)x|?/''NKr溰+ [;(rd_ (J}s5a=fLJ'@҆0W^O<7-~#O;d)@xqҝBMU(ڥT}ma.,y݂S{C(KS9[}݈U6}|$|Ks=z-'^4ҞekF8r{ˋis=bp Wm%3 B*vn y:tJק3e#eTZM 3m2W 3l.mGe| T'{piEG6pi6[h(ȃ48}<%)91̴ #ۛ:c.ʣ ;e.޶qDŽig+D5ObbK$)]?1 _A#A M;דnHJ41.'bT>oی\ey}Xlq"{2.;t5-#ȼ@RĶKu8OrX{}<%0L09EB %,8S=2)FTj"/PUbe(?B.sҋhcocY&Ͽn%v<!vާ3 g([w Sr:u46cΉ6wMU_'NBQuzJ''X8NV3okm?;j<۩ĴPT7McU^U\.7"11 à_1}xTE̡vS1 Q5ܲbS !hh"%1ynTա$PUjQĉЉ((x\xf/S…zu}FX/;&6l8 /7,.9cZvMM#=5<TVp ֬I1;}zWRPl{NdRP!=$;u$N=e`+'%ȩN>c*͐IOoxxNj? !(:f+/|^Z,ʪ2md1omeK%P0| `AwQ zֈ$B5Z[#US]1K(^Ȁx<>He{fQr.]8K4P3 ͵FP1AsY8]2JQTh6PVіEGe2{hKe46w?}0(o4 5y&N !=@yqPTJ;>@.}FDP;bR;S?iBRTsT۔h_Y3mq<28PsJ_(f[,!7g_e?(w4͡GGlϕB8i=L!şMYE M9POG>%y"8^ҩm8KJR6/0-Ỵ P,MdN=Ʊ_ ,s̄:0wK "FNF!!OqzU5TIqy! qP?^ֹP;$;DKmag`Ht=vj*t܄`5,lkk ϒ'S=P-=-ͅc˞ט֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iTT*UU?*UBR*U UHBJJ_R?֪BkTZUT(ZU "$"!" AH "DDDHA$DD""$DH"DDDID"DD""$DH "B""$H$HDB""D@$"DDDIH "B""$A$DD""$DHDB""D@$&WWWfW #?D#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???PP$??Kg5q@@79?~?~?~??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 24PNG  IHDRcIDATxyTյ{QhEA@pq&nK|j>I'ϗ 2_o^4 2I4]g}Ω>uUԯ^{XrmH  {6A1қ (P.ܲpNi'/,ӑS-)m)id (3t)LΔS&g)3eəxLYz2B* ^x;}*RON|Ϣ|f E$(L-'-G" l-X+aM _k/wzֱe\xMgQ*ڱ,R1u> &NH =/E[bѶx1K/ )$B< {TB(@ޱN I1mJIrͅU0=z.JGƷVߊlK)dޭHi`&"8BfKlwМ)؞duǐ<;mH 輛ԠCP~wدkIdM< (!%gCZ@MH(7vw/CRdvɷA0&V"l %a%'x0я~9pf9z(XlsŌF?([V־ A޸k6mm6ظqc>gy&Dz,{"YwN4SZ4LLaRsxwl hBxꩧ'?>o&J).3ly5J)9ûwmPmիWc67{w-[`Ys?pM)'0j"!}[8pGeŊqstRVZE<_z,=rmhSmv1èޑ̮޽{;i&VZŊ+xx饗0&[o*J=,MXʕ+Yn7o_ Z;mnB(ESb2eJfHY_ay֮]˺u8rO>$k׮ {-Dz`Æ O2?1r wg>qF$ { @g[Q(9uA6l :!*Hӟc8PPNa,O\%-;7 dk9gX7:.(B }_ECHPl<ܷy'cq]wqFV^̓>swS__YJ!BFv>fABJ@]wLN7~gI$?nsW"[V<MsÕ^ꅷ!7.+4,zbٲe\{=|k_98LM/V\ gJo[K0;fcݼ@E WeG[ؽD=--b#a/bʕh`&P\ `ɼODC| jկ~x|8tٳ01q2''rK?y t4]i^PO9ߕla:׉<>xO[}S46QSSϾ}Gٻ6g5̘QɈ1ni.Ea@ذaK,΁ "c6.҂+fƈ-hllc:6n|cna46¤c6?cƌ{&pA~՞ߙM0o+v`.{ޚ|ǥ%Euu='f̘ Csg-k>u3v|U@nFfΜ뺽uNu)g<µ"\B&$'&Jh/Fss;.I2i+LЇ}Sybٌ7:Ǝɓ \voo~~u/h]p,(XhD)vWo:G $SI6Ђ.ifg˖t0xlu@Wsm&NȤI0a#]s+^LD?{oBW!P3-@pjp|& $)o<*Vos9۶X~=_F<˯ԃ]l]=ۄ]Ui/dɕ .\β%G (KYt%lRi( N%'бwۦ`̨DJaH,M C0ztx"rJgnu>GQILo1ckM Lфx˴ica6[z?|fqgշFlQwP!LxBN=ƌ#j(L^|g\T+ X0$ۻd.<#b|GcXe}:ԄROk_s᧳'$AĎ}H FK4ۻȱ)5xO2iSWض]Bio62TG?跴 ;RImms硂\32AW#ck۟eŊL:ᄏ v &N<4@̻%#TMBxeڬc7nرc n`0B輛13Jf6tY|9\pH)<qHQGSSWE}, 'ӹyMk ި݅y~ )%͇ziKDܹs9s&ѣm:R l_y{ ^zƖ#?ҡ,np2 ä9yyXMH9邅s>apBʢɦy:p7waK\3)'=LTHRhzdųX:b45:`V#x?Cy& ]3ƐmMЋ %yB.κMA_zM[K')YBqΙy9R(l9[/WKFq_/ъ}ų6c)M6A`”9 Rvf*wK>C^0 y䑜?hK5xl9<0?+?+ZjkkU㴂HJ&Y\eV~ibarDzuMoXo _O_eF_駜R>]wC8*:YQBlh>p2m,3mƹG?ʩŋYjw7>+VF󢄐:]\p{;mqT.İy)p0acHDG<_y:(666"G?r=oA,|$M[^R@Ԫ@"JP {T` 8aAVǶZ@V L`[qbvӰ}OyWFW^y% ,`sa2V/0]ѝpƟ8)"+P-W̆W` GV1K2 KN$q; Ho(z1.?Gx3)ssL/W3)VuСx tdjl4c$ bv$fǵ8Ƕbx}F|Qū̮t}Št==bgLOk{cvWuCgvVKexI:^mQ}Z5ۊk!$1; H(e0{}/J][~9VϘߝ|=f^`҄YB/pxH6my<œ' bVAaXҊC|'<5^E]5>a7g6N?S)pBa`1Qܨ@xL= +3ߙ̿Uu|D1;lL D<9KdVP>'F?a0mSPIa3%¥N5ۊcHCX)a2un Ů;Q)pZH5Я3Qskn"ؘe E^{he4RVd_ bѕ2B!ms*=:T>1 Ӱ6Rwpq1GhN4m&k۟cN\c:&02qiEǝs{.Hh\G,% YoxzQ턣:R_W}BJM=APDK@E\[^Wl{oe B~8n1>@7"t_x G%t3cD_30 _لGImi0CX}%ohϹ L8YB.,'욑ь>n(i<\ݨzN+) kuS8n )$3&+gYp0$dWïBSU ~ij@+s|/hlnx- =x0 Sqcc>^2zD $HwXt^k~F'@#GDP6Vםk&ḩKIiT@I'_/9Rg+؅;3&C"] 'q>F1NK[CY0<˴p!\$.B9(/~$e#Lѯ 38bL`kdOy}@cr=չZ.@i6[x^t܆'NN7UsҁrȊ1!|0J6mmeRXMW 0 fN _/<^/hjhiO4Nha `KD#0-_8n;G]7EN:ؘ:^;"e4i\E!3ϾԷcp} ߥ%G7qt|#dԅXY MwxGyZDnlc)"0m'&v`d(I pB&<ˌ!$n|si'i _vqԅA{|iVF$Q1 ӷ/89x0!u<'d$P,^kRG{?K'Ne}N#e@p!X )8^;\}Jo4ۂ `vkڋ' 'OĄ*ݳ߯Z\8݋"ђѴЉpyĬ$.C$qiV1B ۟ä g.^eZEaUk:p<,.˹MRdF~~ \<ŲL4H}L3Ћg{BqxB+K(QgIѴIAqv:/w#y>e x` e8Pf7yi/4LY) =tS_:ppGxE7Ɵ8˲-41M3(޻jko.]D͖}08k%>  V0q+x禛-!-_)$p Ns:rdb==I_ѽ,Ԭ/az^ɸY|C_4[D 46n wSWMܦ SPlN|߉[]=.˴QB gIvg) e]J D&SL!;i.T@se0;7l`n*f qpd"eJH$)쮇M{xB+ @7fs,qWҞqRHib%ۊ3 b HD^'^hU4~ςSCA<OI*QfˌBJ= ał&,A2ddo6֞ #di1-}][Z]{\T;)Ě-`mimi7!)„0)%w={`/C<#!@ wgRPnoхL%IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ UU_ **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗*U?ZU_*UU5OUSHCZ_UT"DDDI"DHDB""D@$$H$"!" AH "B""$A$D $HDDH"DH! "B""$"DHDB""D@$$HDDHAH !&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???po$??7@-=6? ۫? ۫? ۫??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 25{>PNG  IHDRc IDATxw|TUƿΤ^C)JbADbo+mueUwŎAETN@{q$d(Kfn9ܙg== 0x!,as*7NMF݌p4yGwT{܄{I:>:;^I$PT'BQ4z4(NEQP4'|"7~MS4USp*vN;}\wƘhBE-d8/##;Au!qA3vUwx:$4Ga[k`ʈ%CANFvdg?;xJmf_ů릏4$I6],g#]D"K2VQq iх?}fұM_dbxS؝;xMnA:N^S9vzwwT+4#vr:~c_$|zm|WXj+Ed,—?@QgڇKc ]x{)H@TD$mEܤDTMek뵽rNc7N;5gф>zwKaqAys^D`P8EoZ\L<k 0vSжUzms깣 5NH~a&lzQU8TUf/&? ]{~yĖԱwxf=h@C3y)HJI$UwTqm@Ӵzm?Ofn #h܄0Y:PT'Y[A&1zm܉kNc_\L 7]aWVXGb{?o9LMՉ, B'FY@_5X'@y 7}\pdAX~ȲYX ݴﳭV5 ќLdF@`~5D?~ w',c,HUSƚ!,:$ GO_ljS쯓Gꏴ/ ; KN K8ĥ=e=FLsmXUP] jz7 NBxhLqi>հ.5#^I͡?\q;c 6HY_^($ ](U)B+!$Ŋ4 oAxhS7QpV[]Qs) Ԑ:{N@U hWU9U}zlњ(,Ͽ$ЌMIGYؠ.4x]j׶X$ ì@,IX#iղA23@$_|˔$X (Z1&v$˷`ϑH&;QUq\XLyG K2 Yw1+y OP@I'~6dFvAZ*dg݄4&  avbáؙ1v)GH=w3I AЈPFR[!!A5 e:@p`P*=bWn(w8;vg)vG vG 7xƧ f k௻q|s&qTg /B8vHU86NTXJ8Bj]16 !(0Ԝ6'$Sa*,aƍ^5kI'Ջ 3/~B !8A|U8:~;OX,VVYذuyLQ8=.,eOV[ޜ ?@2sSL+4mLӔEx(mdRb+^+o_a|q`wxGȲ  _"K.%8j)t2mq8m9RG1iSl] ψ>YC\?)S ($x@yA޾]'ЮUBMBR_yZ .?,i.q”ಇb^uSq[D" 5j^QުpݲexEwbv{"ڵITDk,0IzY#زeKn%2=iY*W)u1:vo9xb+;a:Txt-^+Wq)l#cE˨eTkkStj_L|>vzx~/_~?.x|ښG=/ϼo׺X8q1 1}Ֆ3tPϋw}|?.x|ښGv{Y+뱯ZOKs.6QLuOu3s_9s7ڭY6"y'ϟ:&1mb[*?Db qa~0^7ܖ^xs_e품aw2b%W1957߬ '$$0j(}Z~րy?:M +7/\j$ʩU?8OM85qFVZŢEeK}o9DKR5xUt 5hneTC+{Wx*%ξc?z%7L~^z%yJ/q^ q{|=GʞG'i±cx晍t| Ȋm^-wI.7 _믿oY[n %܄|WYqAy__|.&Tj$? ͚5"=t2_~ۗSt@p4ri#nbN|*k%::ݻsUW;PPP@@@7pkLUS{ [SucGŘ ޯ}aok5^Mi|+e=cu*'Fww{=wn}b^}bx^K,xW3w:q@xh(Zi)~P`M] ť!HU y"[8y;*z}L{Ԩ׵ah4>Rtm;RG14Y>kWMYNuf1cưyf %8 /5YI%KUr9FC K$Brbϝ;˗Gs}uN)6o̟g 3-̠VCICgLy 944 4֬u<;Ph3ei>_~9:tV:IL։އox $"RvSXOt?\깟$I\wwEF9J8PwCL_zYQ]1uM IduV9uT."ᭈn։Gwx)"C\Lx}ޯ[-Atk?VׯX441,ѧ˸/q1bpiKvgSmR\Lxt 3 1!Hֺ̡_~;.ZIui7adm"ï-) .]v\s5^y _g&~pq~֐^* $I.)\ YR$ ux$GwRjYʕ+]kI@\Q^d?Rrٽ{7}`„ <::vs` ]^w=uO77(!y|Y'kת΋*Od]XȲEB}v6l+:u*CX{"-!_=4-K᭷~O^|qylĈ8ƌĉs6ƌxVv(F:W0Sbm}  w7ϛOII 6O~][,I:U̝x/]{+raOREZ_ߜѣGnݼڴy[6umj_W=1oyQ;80*7wpP8pV,cu] >H[ WѾgO~=7liӦ|;IM7564^~k@ /xyE|ų>ٳYf w.kB㮋7Tz#W8ET;_&[oժih֤k!5͛Ċ1}D|9|c '{W_-:w\SXmʔ)⭷ުmf~!(wyGwJ15)bŜ wk. .{HR,ݬ;*E7ps[FʼnMڈ&-<7k#:}u;N*No q7|PtY3sL,f͚ ǧUrSMW 5M .FsbxW8OJIo$| ndI$or5pHE摱`[9J9BaI.ҳÈZcݺu 44tmƊ+xꩧ8rΝ;WU~)ڵ+_˘=~:=#>̵Rj1O{GJaq6Omʉ"bc߾}7$TAnAkf'80r5A^^=oyOWOc۱S+>6í~#D$~m_^J)r@}' @4K~6IDAT%lN9A$ H.0]f_ҳNw. ՕwSS7*S'ܽ^y]@_Bik]9 /q R&y $44&DFFhm駟`̙!Xv-> O=UiQv}nΝ߿s/:zCLzw '߾T>ew4jP=׼e4W-y kFdde!v3gRն駟Fe<Ǝ˨QxG=_lCa#WœO 3am{t҅O>t Z]랴kݍFdS4tэF $Wr} \ѓǕy,+AҸq8QQQDDD!??3T}ň#4i=(3zL/v@xh1&K/mhԘ~|pn\ӧ),.ХyvSf^ichoݧߟUuڴidee9s hpsqsʔ)DFFҷo_,N/=u$X#= 5 oҸQ'ơЭ¡K*-+%-:(Bʣ&0f Wo|dӦy=(v#Euj '#9CeT->}O~{ԣ;ɹ H{ƒ$hL4;cǎOff&G۵ItmܨocH>{ؖ8'@ȓ[NnA:5$|]MЉ_n蠏 e8E7UU1*CNCd JJJxvg˵=?'~cz&qT'gc΄upӇ[ [$@001W]e<Il>у5{8M+M.eiMCIIIS⠀P4M1[yw*F!MN^4/f ckK/Om[t/[|BhCӛMeɬ>]1VҷEA@wLűz=\yfc|C %i8CtM7to :/ڋy }뙴~ͷ/2sܟ1v)5gy^ Y:dʕl\{׏Ӈl5.+=Q!h*U+VZC@2oL~~>ײe|¬YPnj~GtQ/-y{ uRɈnޙǯ/Mu ݼ.I2τ#ISVksUTlO'F51ڛ*MQDQ鏡“P}tow@YDV9u7ZeEئYTTVJ:n՘)p]6lrκD"t׌Y we۶m̛7P 6zjzƎyWO%m4 i;XXd|ѽp_1^˲lf.(ad9·@̀K̼TZ24H"4DRlغ )jOW+RyǗ^z"^yѣOO>I&zjƎKBB~[ƪ|9XI|)¶_z;;ku5I4MSX)|=^ :|p͛ǟ7йU~{޽ڵiUVֽ-2btOqP/FD8P}g&9Y?.& %$$6"u4撛G~~>K,N[o;R2Wwu 7[SP6-?J bȼZc rä_ q1|x~ܽƘqGYIȊ٦#44Pv;v͆o}N۪_m+2P~p:tAN~:uP@j\]iM׌CSj)dI5"44͆fpt:M.ܲ*CBBB}azY,]o}ٳ=<iVZoe%vF>OephOsNT\iKJ *Sl?SIp-LݵyNũxq(+FE֭+ޫlɭ=b zW_ͦMXaD vg<ʵWyB]t`.e{owagX~sZS @kldG՗k^cdY5 抭*{V:8N;Sj[CگDvjwTHn)w~YϱmzcX = Y5H>zja 9~37Y'3d#h | !P5{R[ ;Ek>Stڰ;m؝%D6n_- pjf7DTwK`o K85]&$ո5BwK`T+$ȈV|Cur k2p,B|깣 ᩶9wG^:ލs{95M3C~Zg22$lb,[G;4/ȊN2T$h\>-=; 2lG18e`t1FT V8?p=Zכw~"Tp[<..XaE 1Ce&0#Bkiz:ֽkQUQz!_|مi_l6}fzL[7^Rz}e}t`it&tKAq6t*dd'<6 ͘ Zb-2I)|CYpw')Mq7ςlmgcѽHfnOFR %#_n/sx{\ā2giON;HN=j&2uIET;~J\SIO 7=S0UY!B,JNaq.>: lD(-QXu ᰛF{~O|BQd K2$#IO$'?̓@5z/oޔ3R-tGM ?@9Mڝ_3n7ѼŠv08;Jk‚ic!@q0ȡ}J=JvYv5Tz GmK8Bώ#}.m@߆ *k3K.]C8m}^1G'Wqi>!A(Gd JÕX^Q&<:8TPlYP5 łE [,DdD4i̱8]uwUxyr >B񣪪))Wa7QJmLH<\b14I9y%d 3ٸޮm( NŊiHU.C-߲&N2łj]2Rg?ŧ1pF:l"A9z&/3My3V%5FUϟda\XeѶUO= 8;Vϲʧi՜W^_T7Ë ^1ur_du8u7fd+ o.1uM4hm&E9ezfϾ~,30s4Љ3"TPI:Aώ+kQZϷk\3-{\UB~P 9-`_tv!(uq&(g3XV=zj%bӶwkЖK';q ExJi%kmoxZһ1>~:LnK2\)njNnLI?'tډC`7d._/+e{ƹSF?K_8g7>:Ӱ+׏?f,]@'5]`N Z/[-Hĩǥ*ɓ/^G\pY_HHLzO4l˞#ߑy Or*aFe-nZkv"/dOox IîYNe>; |Nh$hNg!ӗهڷee H2c/!4&}B% u?@ʐGd TP=y\Z!H:Q%T@B$(cm[v׭Р/\mm$ϾSZ,@`GEhpZ4:ǤG@`!NjrO;]S5tn*/ e2@L.FED hլCSG674lKpPcߎm!9& 3dޚciC`;d.WઐJw$4uyRjiez$dn^KSU1/zcɻH8}S4ʄ ]6$IXi rtsy"+/L ޝF׬2:}}4+ C=jEѝԅfNӮuO>Tԑ 0>9îCp~NeޤYtEy)2r9SNYZR кYjOԧztWdRv㋛4T!4ӸQ33}`9D5s5(CVȩJ"9 ť\wy94R2x97ԌuU( )W'ߧE>[!8!TTM)UVtolJrt7V?^2&1@d]_I)9͙s(pZ叱k\$ 7؋2J^9^Z~:p5 $2wαp^t;\GHP8BV@QI.axygY$IYhrw֤DҳOq6+ g \j7l]E`@0er  #0F+y tjWT'tlӗ.m7G d!qk4[> =uK|[=2&@мI,+fkj) ڴqk,’\-BQ(FQ\mХ\b+Oώ#),%9SPg^{{TMey&C\L<6G16]^%5>hF-Ӎ?.tnj7喝ѺYZ58.$$zY'vrcw,x*!~z6BIйQH(@H&"š뤪5qvyȱdx>n| ,dkgS|;bT?%ʿ /q[]mV$If/e2w$%င`ȚX;ytKN&-(VՕF-\ayjw934ok: ~^Y+Ͳ8|r$N_ Ey$%B#dj,oߺ'ԩLto?]#n/Be,C@Zf] ɪreeT\jZ_FӈY~ _zC'~EQ%csУp?B")uLZ /q<%3֞ k|籺%--|+DzDY4"'x8# LinPPMXh$4mҦs۶AVsM.+WXsfn*6]! fZQ2$ɀ )-bټI,PR5wv&$ H Z5PfpTMuCzΩ51ʳؘiFliq(WsU6³M M#b<#k@`r{|wTڗ+ݯ&0VL A2sSӧSbxT;α=]B2rZ**F75IaWePJ>$4`5CvfNt?Yw$]hr)]Z?_n- [n~ſU~>\o>6.?u?v2'CIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDr%/ %/, ꪪU **** @֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! ii¥PU5OUSHCZ_JU_J_) UOJU_UHTOJRUIURBJ*JZA$DD""$DH "B""$"DH!"DDDIH "$HDDI"DHDB""D@$"DDDHAH "B""$"DHDB""D@$"DDDIDDH&WWtWfW #3?DG=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???PǿP$??'@|3=?`:?`:?`:??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 26pPNG  IHDRc7IDATxy|\ՕUI*-y-8cf3=IBt&n2M!Ki&!Bai&M;,XKe˒,Y֮RUoWTj~u{$#Ӷ  =ײwh,}P"R BȧmPô|nhDFf"rImA T#75&A h.'6| M#_e7K>`5W$yBHdiZ A/:/SQ RYH9BBJvHC:Pl ZǦ]C iK hMR?jдOVV6P_匐' ~,ı $l `25oA7G> *5~3d@h*0/ dB! F&%[la y=Y U6ll@I\iW,{8VI m I?q`z)y.U'i~z%2iz{/PRJT)!l(l* R⑒/$B͘l!  PvQXŲeٿL:EL 'g Lb*yt#!ybȑZV̙z8Y45uY  ( q88r}.cؐõdehk {:"σ%77>1mkJ(iC yPUܼ>1$y M [!8,>1,ɣ#K/EwA}rsX8>1,c+!-FZqa3,c o|xn<!Oк#.n>?_f ^Dž9Bx`4[ǣkG.;<ÒV/3qJTD7t  p8z~һhl #C2Ə|ۼ6dC8y\:\MtZpZp5لÀy ,sQ_/JKvB4 lery:pp5tttQ4ntSuNOrsyOo 1P&_ſ'|Ȑ__OQQ.&MgwN0nONr0NW fz_Xmq6x۽jх4Q=75# |>sPY "ÑE{gpiU]I $|غu+\s wfQQQAqq1uuu<裤7C@p,WLx[1Zq~:hoP]ȉx QU]Ѽǣٹs'+Wdܹ~ʐ\^௘0\$m a`!Ou@Fenjlܸ׋墶۷S]]-q _dl3~xΝcǎS"ر2Z[[Uue1IXn{o}PIe|64i ,Yų۹k)**СC<3},$=ÿÿC ow>zJtkhX禛nf~:::b>}vnFNJCCv/t8Ǿ#>e`O65M6LliӦ¶mx7 \}՜9s&3E_A\q2C</poPPP ͥ2ݛp40 bt~q:蓎yJJJ8s :uʜiy*[ͅXl8L{oUCϢ1 6l';˴߈eB*״ݟ4cffYf MWݧu )RQ(_ >ummPWPPnኵ !!k7R.mSw jjc\lVBYt ?yNpSO=EcccBJs5x"|xEi5<vn ћ]3Ԗ:r p{cǧ ZJ'f"|1HBUCIcv X Trk/%]t]z/Uue- n(;]2܅ 乃()Sr(U~(5}O0gR ibٶ-erECtwuL§h1lC2JOQ?_p-1S ]FXQp2[J艕jǷݘK71c>}c3.1n_ {g۶ jG)\?TuIJ\{Z1l+:R_A"<Έ߉ t$k cuO1q_ =??8ϟ>AqfPDU}aFtKפ2!q{;p{;\'~O?󃍇R#P/nMbȰeɘ3m)b'/Q(#']{LÓĿnCKk]32JIa@Ӎj_ gdO: C[6BrRkyޗ$xN~7!5ȃ3g@j%Uue.͗Soz蠪"x}._)dS_Ox!ܡ.qA}id8{CB ߍFk ,_'̕nfł[Y`SK(ZfOXJi$ K+7{l r(,Oaxs) ~DTg܊^{"W]YiLr$:GOE:qb,&Y#[<P(yn|~Rdg9UEGK#nfUf {Hޱ2=9iy \5s=1&2pPqS@fNfAMgeTIh gUue>ߋffJtU_U Q{ONuy. r"CM )r o ,W0h cFM$ oedFѨ ~OG0Цo#23k,gƿUHpZ@&t9i -]-`s͖2 m˴v\" "JݥӄGa̛"u^k3{Wx$ߕ4;x;]x_;3^@{gP U|\cғ̝,ةA'5ny՟p4I0䷄}w6ijK5viR2P]:Օ@f \D랤';\-tx;p{(/ޝ+&f;Mɺu&)N $LacY4_K"$<tq?_'XI|̝_H=B"R"Rtgi a7E *guhs/#7ܜ69/KCRʻ?JIC~ny 4ln}@Z:t p΍H)s>Ve!1)V―$<`IޞHsb]̃hC+©,[9u8yкev<Ѹoߘ'`#@ctxNA"##&D8ؼ1}aDXiavy;GW70cBOR&[ju4kF 79΂NAJON&c5^iǺNxg#y.kuV?ፏy2BM:5.2X.Ϗ'C: ,4Bni< @ad Jhd;"!OuH ѝO "I깷1BL^5]S'OhuC\vl<@jR0yƈ=\ydW]}}\z_V-gP'Oz:/!ϠIi4&a$z:`<^_g)l8kWKpĹ Zli{4IENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSD@%/ %/ _ **** UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT1֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗U?ZU_UMjUT꺪֗T¥US "B""$D!"$HDDI"DHDB""D@$$HDDHAH$HDB""D@$"$"!" D"DD""$DH $HDDHD!"$"!" A"DHDB""D@$D""$DO&W #UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???jj$??* @G:?@B?@B?@B??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 27W9PNG  IHDRc IDATxw|TUǿwJR Bh{AeUWWW_Ե쮮+T@TޅHM{gI&b(_>3{9! -਄]~?6=cѶU4-'։w{ۀK(BAUeT"I,Ɉ`@FF!кu+ڵkGv\mWUU_`M~M{}$a;XUR24BCZ(2fS¹;$e+BQU \ڶNJFW>p'q B ! B ܆Gֺ}=$a$ & v?łj+!q6lv ~xVa0O wU k v!PTl680^ye{߯!Lu`BCZST /YQ6Fw:{ܭYs>G4L'==bن^nbj>zzY`0w7p;1{0 *`Ajo{{ġiӲ`ֿΓpp8m|m2j #G*{s]sl˯~T6 َaf`WcUaWbb; @AE'$", FZb!D":;QQE~ 1ɠ۵R2xزCTv >kC$!sAAjB%w=Kf>@BU)-+d2d&44,<ʀB:VHNӭ] <{wͥk{Oy?x^y"G%`NGxhX۶"Ւࠠc0 ѯX䩋d:Y586d ^Mz[Mt\/4NG Y p;uSV:~pB d3$#BHBE9wqaIOm{\>~|P54 hz@CK{A o?̼wSx;U[L ?cZ`U%7η;^xU㲱7ӡ¨ݯZgbޤ&/.eho3܈ؑezMүJ\?1}:fGMEMF)0ץzm%a]3qV79p zwNAlO' ],;;cC#TZJAեHW|@P\y?O`#eS PeWbNU7V^6Hڌ3phlZ"tτ#_;@Qsw_2PٰuU&lm>D#τ7ewh rsgnJ.EUxk r{ Bp̎_9^@pN@0g❮GJEn Ȋn:ӊiߋC}}7HPڪA.&ůedc8M{Np)f!6 =30n<v]5,; Y)1֭3H$?HPF\MJVZAh&w'|ŪeS[XtDqVsF.eָ[3I 5uANY6TUvi|ULaR2x{n4@&}kg= M <*H&2S,+(՜/[[;7$$I ī> !!jg#u %L0 BHH7$*dpjwܿ딌H .6d2b2mJXX;Ee^YY\9#bKT%QKaFٙ`̓<$Pkxx>=eelUȲ s(9'/`ڨ=Vf z_gAHg;BQŁwK2) >Œl&,,pl|!LFF#]AP@mR`G9X `9qWAr%$^h `:PLOY{q$0M;Q-rTc2dg&U3o-SP? Ҷ`&C'6Wӈ$22EQJhюvm:б]'nߴ* 5:Sv~5zwQKQUM7~SGv`߾Ol?Rml 2 0{@M ಱ7}-_1REG/hlH>B*y/_bZupa=b0XR>BJٚ) ARh^g0 FnOi6lXho91̘%#B|^KQك>Sk-[$kP/UehU_MEys/Q"}wjyH`G^X5̝/ׇ^ Ԍ78&maQm)b6`4ϷCm4qF0)8ۮ~̥[RUϥ0V^9Y'瞢cdw2{N\V`;fv̼݇~ѾmV(*}Ar~6t}JҌ~X<\~)iYg8qFSg?}w 5 Eu@m/UѤ&8jk$H<ݸ?UsTz[7dzMH86dَC#ٛD#%* (2~ 'ύsWm.s> ̢T~Ms:SF\۔مRCUFV ]@䉋gѯ;,86TU8NE{<)@@8mnT_:ϵ0 Nhm&, )1Xs%1PTgI0>CT*-YvPMc%n@ǯ$IBiE_]ڸ(##,fwԃLf#73S}tGs-:C~K*BU]^i{wNeOE} >L~-A s]*fhi̟ _o{z6Ю! }+:af H0m2~<_}%֪MгPmJ j08اv?.3f\ڶ$ذ5k'FV<$q| E30v|+*4uA D[j:H :Mtdw"[wOב\Pz{yB}YF˥eK~'j昛l76zu3%Ќ4ykio*n!tp< Q^YB1f5͂PvDBҏҷ(yv8Nz"G`M rfqﱍ,ܻ` JrQ s-ZQBfCsI+3ӹ_9FdEFQ@|/ȳt]:xɌ`h0a05^ֺ^c;s"3}4]tnV?(,tm1ɳ{un]!=۳Ə{pgEu1;~;is\G `Ȳ K.H&5d$}_aC'#7$Oqy.SG.k8"J* (w=m߇:p]zj373p.doSHi˝;a-ZUTv§/Lkg=H~QDAY(Òvd&ӡ7eEM'BJF&L`&x'V< @{NZIb^^Q*#{d5_(kTwu?t TtT!Xq>E/yyT۱/Q!t9I0jdNcVPZYaKOڦ$IxO/$"iޗ~OVA2eGZI}\Ò9nso׽,Bڨ'+v>sBo8BWUD$69\V,eV6xd埡cT@ؙmw }ke 7@PVYi@hNOM;枥:Y^MEHBZoߑgT3~՗=@EU ť9#-$r͏#+\ljʫ2&_aI&vb1SfRXMai&dd-|[VZGZ/>oZ1SR6;fM4DzL} mwoבgEd$z}U!/Ңw Gp6zuh1lD)t"r|Muq}杚큄3xY|Ë7ܥ[<ՄnIS{#[:=ƹ,Z;9Hyeu &c#hEDhkZ;f{O!C7TU%0Rڵm= i9'1@uOdpvFFN;I){HJ=@rϤdAQee7VPXIv(,@4۷ڠgyUal:Blt?n_:< s̬3ڔ+v{5`p)"%Q-yrJx {q`Ye!#-JOב$uCLqԂm> zZTĹct4QUjq(x;PTN{!`zJgUSQ]LaYEG;DXHK<^-:Dpov QkY {vY755adJ+}4AAA<ƅYco!CTy$ AMu~OvYss8=Ef^yIukt$/qUWi$҉v=TRCBZG!l) DUD) xN<9;} H\9^~<B֫pTUF2ꬼeo)y>,W͸.~gzَ̝sOi|o!33S[o6eo\| [Grbfi'$`'RO]g&ҥ IYe#u%PUn'sEC%-vwW= j[97]Ϳ^}>oU9k7nȡCسgW\qsaӦM<<{<裌<1h.G9`6 6l WaN c?C'7I+ YuõjHZ,_8Uc/W ^q b!w4wf޼y^"T4уbX`0"4dp|yaTu+t6Y@eu1>ǟVUaCWʚMAk)p {`\ F=y| Mbnз-zX7q?7f<*K`NE[|ԅ3٭04R:tO(=XCdn_O'z~(ײW '>t om$UEhaքɳk"B֭]stvۈhb@xZGd!-92ho+@Ϻ8p 111l۶Cې_NdϕKs]w_`ҒHpeڵFQQ9>k ǒv`0tIDATff$a?2;6̙ÕW^&;&MRV~31cưyfz~am ²,tﱍځdpKQ_7.Luk׮5WS O|rBťv_?~xjpϟ^+q嗻΅}땍x_Xj_ڱս=Y,aq?>k"se}7.ⓥ1c \Ŋέ]V\wu9P'ĪU?,1tP'|ꇇ1{y'΋/֐G/+ {/|z篾qbҰ%"}/%3Hm[F\RW\֭[}v;_g…qo_i}+66fϞͣx!?Aꪫ\B0h!`Μ9~0ۥgqْHHhķN$9uCeB'pȿ>_'5}nڹnpB:uă>ٽ{7QQQL4ɥk=v!!Ac"⡇r6#pPnu#t__'sNڳ̐S0(5Y9W YuLpP Lw>d ɻ.!Qav?QTms; P촉hOPP fxIL[s&IDX[)8N?Hرc}.;qb0 y)+ `0bUQQ]Epž^6`[ ;F!I0w]FR2HN?2auĴKY5Z%Ce"|*KhM%!0wAOm%,Cz1z6m\-/{Z8sHJ=HjqRYoXTaLTOs" îd4{wpT l br:Zf5iJs\^B\t\6&!q6(B+ v'&M1f 3Pe- K [% I? 's[M}L.ZYcouDrXf1M,_4.x#d\/!\UFTZe}+sѧ=;1 g~Kmq,r7p^&]ZY|{ )1v ;3Wg>`ɀh ϊF_У` n M8B\l_dnAEu Z_۵k|WqXS&\N8w.yN' %e5^ !2B_E]WN7]5v@​,󄅴h4orXl F7R=9ÆiƴZ'M| )|JHL=#С4Js8q8~&4@ClHn\_!}_D6|kʋriOޅ?0pX8n$Q.gH@YE uiS CcW3f^x%[Tq}<'{Y0+uN ⠼. 8Xb 0ׯ]bzҫoW Dzozڸ?VNai=p } SG-ӗL^#_"!68B^T-^ ?UK_W]?C Jd6: eOI¯\ǓD>Z`^xbZlI}$~xEգ}G;UJyU֒t3Pm ܂;<[kݳ?0cue&co碒G_o7Eqx У!!fW.N3m2Us\̜9Ν;ӧOfϞ̙39s pds^>~9bj.[9}ܕJWUU/aVhFzn<%> Ux;ZGt d EH ^H/*ydفc9YU?`DUǂfdY^UBiEɵFE1k{Ǐ'>>^׶l–-[HKK^Ԥ3SLaW?)*q㩶V]V}ZPS;fii!CZNxXZk77<6:pX5mZE#ʐ>KFF1{'&&9;G`zaiӆS nu֯_[oRFiE>Nw^zgoYSVY=-UXmVץUUa Dwլ^Z3OMUVq j<ȹsOESZYQOlC\9zB S"}/^ 7K<zMCXIˈ[ ;**(.-4\ KݕdYgC15HJȒTsOW~G,[@3xbөx']]FQF3|T^wqIlj^]lnhơh6c[2sz˞Dۗ4kPV<嗤$W!ܢ`<b]wo3 /5VƒHK}bXi }Kn[$y?0<]cݩS#0CȮ[oN<ɺu<ԮA&(2vFrVhk^N}F]S{ sfS&I7{;`ڨkc}_A?C@J}X:obZnf,[w|I-Ǝ;m-`$-pذ9iI^SxSȲ&8xc L6L΀Q@eE8d"B`WcV`sX1MAEH8&c0頦1:tkgʔ)l۶Nߘ`siӘ8q"?xW~*fY8]a>j)BhǫP bP (J|)z|sY Lrw`&" m" #Lz^"CL]^ķ%NWgĉc}x;xv-wL<۷܇6ɢ9B8un]Ԃr׻[Z.!z>7'6afV*مX|j׺zچv:"$jK)#+N拺1Tڵ+WiiT%O˰vD!4%Axd"sOe2(i#66~x EPXVAǨ TBCZvȣh]TTSTՄhIQibc< I?/9<, fsaVV^tܙ =OWTPT*XlU(LLtF~r]퉺x ODṚ|},*+ve.|; HT#\/;;3m4>W^ɻ@KǙgLD/駟}p= }%$lƥ=.0_y{??ID78UMxB-Jqi)%#<V3.:ӌLff4#`4<iFh&O3F3y0ӌLff4#`4<iFh&O3F3y0ӌLff4#`4<iFh&O3F3y0ӌLff4#`?:WIENDB`move=1000;blend=1000;3GSDB1Q k k ֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_A$DD""$DH "B""$"DH! BU,tcf UQ$I$HQI!HdD@DDUDTHdUUI$I$$I$URI!HDUUI$I$U$"I$DDRI$@Avbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 13GSDz%/ %/, ꪪUUUUUUUUUUUUU_ꪯUUUUTUUUUTUUUUUUPUUUUUQUUUUU@UUUUUUPUUUUUUUUUUUUUUUUUEUUUUUUUUUTUUUUUUUUW 3OUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUI֪BUT֩?UN! iKUSU֪RUN! iKUTjUkTUSHCZ_iPU5OUSHCZ_/UO֪WZIu]UIkK/UO֪WZIu]UIkKU?ZU_UMjUT꺪֗U?ZU_j'֪uU$!/KUSUUT֩?UN! iijT*UMjUT꺪֗RUTjUU5OUSHCZ_UT*U)T*UBUTJT*TU$! ¥R"DDDI"DHDB""D@$$H$"!" AH "B""$A$D $HDDH"DH! "B""$"DHDB""D@$$HDDHAH !&WWWfW #gUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT=vbinding site for residue peg a 123cc5551~binding site for residue epe a 124ec2 +OQ 1vbinding site for residue peg b 122cc6551~binding site for residue epe b 123ec3 +OQ 1vbinding site for residue peg c 121cc7&51~binding site for residue epe c 123ec4 +OQ 1vbinding site for residue peg d 122cc8441~binding site for residue epe d 123ec5 *NP 1vbinding site for residue peg e 121cc9441~binding site for residue epe e 122ec6 *NP 1vbinding site for residue peg f 123dc1551~binding site for residue epe f 125ec7 +OQ 1vbinding site for residue peg g 122dc2&51~binding site for residue epe g 123ec8 +OQ 1vbinding site for residue peg h 120dc3&51~binding site for residue epe h 122ec9 +OQ 1vbinding site for residue peg i 123dc4551~binding site for residue epe i 124fc1 +OQ 1vbinding site for residue peg j 121dc5&51 ~binding site for residue epe j 122fc2 +OQ 1 vbinding site for residue peg k 121dc6551 ~binding site for residue epe k 122fc3 +OQ 1 vbinding site for residue peg l 123dc7&51 1NAQk  -<hWjhPkPkW ֡P֡PZ֯Zց ?WjhPkPkWDT?j ZCZCZI$DI$DAI$DI$DA$II$DA$I$II$I$.f $UUQ5UUU*I$iUURI*MUUUUUUQ*$UJUTUUUU$&UUURI$JI*MUUUUUUQ*$jUUI&I5UUTMUUUDI&UU' vbinding site for residue hg a 1333ac1I1~binding site for residue mbo a 987ac9 OO 1vbinding site for residue hg b 1666ac2GK1~binding site for residue mbo b 989bc2LL 1vbinding site for residue hg c 1119ac4HH1~binding site for residue mbo c 991bc4 LN 1vbinding site for residue hg d 2223ac6H1~binding site for residue mbo d 992bc5 NN 1vbinding site for residue hg e 2226ac7I1vbinding site for residue hg f 2999ac8HK1~binding site for residue mbo f 997bc8 LN 1?333333?333333?333333???????@???hUMh$??t8p6.@? Ї? Ї? 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