="3.6-1h/data/swissprot/ 3OYT.pdbdupa 1FJ4.pdb'[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]1.84 Angstrom Resolution Crystal Structure Of 3-Oxoacyl-(Acyl Carrier Protein) Synthase I (Fabb) From Yersinia Pestis Co92[/h3] [p]A.S.Halavaty, Z.Wawrzak, O.Onopriyenko, S.Peterson, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3OYT" target="blank"]3OYT[/a] [small](deposited on 23-SEP-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [p][!--icmscript name="19" display slide=slideshow.slides index="Ligand binding site 14" --] [a name="19" href="#_"]Ligand binding site 14[/a] [/p] [p][!--icmscript name="20" display slide=slideshow.slides index="Ligand binding site 15" --] [a name="20" href="#_"]Ligand binding site 15[/a] [/p] [p][!--icmscript name="21" display slide=slideshow.slides index="Ligand binding site 16" --] [a name="21" href="#_"]Ligand binding site 16[/a] [/p] [p][!--icmscript name="22" display slide=slideshow.slides index="Ligand binding site 17" --] [a name="22" href="#_"]Ligand binding site 17[/a] [/p] [p][!--icmscript name="23" display slide=slideshow.slides index="Ligand binding site 18" --] [a name="23" href="#_"]Ligand binding site 18[/a] [/p] [p][!--icmscript name="24" display slide=slideshow.slides index="Ligand binding site 19" --] [a name="24" href="#_"]Ligand binding site 19[/a] [/p] [p][!--icmscript name="25" display slide=slideshow.slides index="Ligand binding site 20" --] [a name="25" href="#_"]Ligand binding site 20[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1FJ4.pdb3OYT a_3OYTB1  1FJ43csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) 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R7J HihuV/ J֢ThS `j[w .ʍ LF4PC#=^ݙv%7y33{9e9yzO=Rlfz)##,o{[Yd.~rIdO Ak<rŠ۷&X%Z^{kkx<޼uϼ$tF8oh1'@S?9 y.2'x-y"o TK &0=kDoo9OAAp>KY[o4hnH 2iщt\0=ۏxG+bn8xL\ YGd0;;Tf|2qZQ45ţII.;JnTKBDv !u5(_F*D nNss4R!#$s lUڀ i'oj /"ְ܃,TjpJuRCÿm5D?GOHImJdg)100Z+wW pothy ݶY䦇/Ec/p4MU!ҡԠHkW;X~Xۜyixq؈~DylJwc|Oa"`\'O")SQMKjq!9ÈGQ -;[++\_^m룿kAJF< [xXC XZ RSC#ꐟ'=/5B͢פc'&sħ"2HDv8Qܴ' 2X~$)Id#g;<9­TӭVD6W,8OID"sW2Dؿ?q*T2doyk~kBQrFO'Ϻu2 k_;6s{?On.-p~A*3IpGXczϗ<6Lva; Ӱdžic4la0 yl4]][IENDB`move=1000;blend=1000;3OYTB1y)4 W֪U֪֫UZWUUZ֫jj֫j֫֫_jVUWUWj֫WZkZZW֪֫WZ_֪֫_ZZ֫j֫Z֪j_UWZU_V_Z֫_kZZUUUUUUUUUUUUTUUUUUUUUUUUUUUUUUU$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???B:$??;Dm1@?B?B?B??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residuesQPNG  IHDRc IDATxwx?duHe[ 0ƦtLǡB% 7pM.-YջvWgZe'̳3{3s Tg/222222OpnogX`nog 9`\v8YY IH1woFp!qFxzNw~s8#<=`:M̜ NgzS%38E|(%sOwSN>U_嗏sJ-!#"?wy#Gٳ 埠ioo0Gqsr?+b1d{ ]LsE\秽8 U]Xٝ>by-dzBx N8 UIt:a7CO Mfѷ}UBѩ^>q27)O'"b"KU][N|>??|kj8ߣR]p4}ƟR{&ruwOSNǯ{X,v>q1T~J< ;裢 @{4G$#a2" EX؋ЌF=`Yurs_ NKО>E_}ueWLmjNxSk$,{=--+b/F|m&%[ԡՎܹꫝ!늉þ}|)aa9xke 7jߔh46~qmk41'vp4`<>Ԏ,"D :@@GMNL&76(EYwu ^&d747n+B\jСnۙ8=2oѢGxҔܜ;=? ~9K>۽w߽ ԗLsנ+$K]*Uxе$oPGPt/4xwB>቎Qd#^gGddcg$%}F@a>Ǝ]qD{~MPJe:xapL^_hQ{[[0q]owܱG~MfG2v1 Wdd>oNi^GJJgu8F븸gz-;3_Ny˗HLLI_.Pȼ{ׅL?+x`ZycEDDAs\z⁎#slݻN ѧ"1hr1`5b5BDh[Ej-"=.yFG?߮,O{+,[v> "%e]6<ЛHI2( huy QjN%2r}|KDD<^>mOj6į"<~K!nn߾ VEl IR弰Kpƌ b',Zt7]6߾!rGB`tms aa;!ۡc2݋۽8p.MMDu;e;Bt$?|x{&S &k]懇j- J͝MR`.|>g}1n7yyX$ ۡlcGzL̕嫰kPloP/_<-[d zh-"` 910 jjrp8P<$"b GFI$A~BEE+8576NaTڟ4jj6/mqV:FAYyy'>3fJC VԴ>} x) TUgysϟ#g '#IkVgRBo>(Å!86~#{-(i=UUNz:уފJSS0IO:zvwyQQm! }'l@B3`%lmh8XDG$fOlw8."J+ŋZ aܸˉ@ltezGP"=|o,!CXWVVlfgkKz=9@I F&~n&S4_V+8rd)};s̚vo1g9IR݄g8e:n23}Ȳjm|z%_F lND(^ڰ^$M};>CxBC*Z[JBvLA7B‰$i"`[V 4?ފVۧ$$@d`;Ƀ4zt4ZZ~T.;jjkNt!,l(M8GDLcԓsHaZ[> p…,Y87l $I tva@JJ`RU]᥄7ٽn5 @fsY͍elذKfxݩL7|&!Cn!- z?<_}>YYDG'w\w;ej~'- fS'χ";~Ea#u%?̙: rٳg0ǯdʥn#L9dd\U؁Zjk*+۷4M{~l\BT̐!Ow\ ?^:'%<#Fc%)/|.%%(nd}o)-]Moq豒pQXΝ֬YסRT_Vk%6v6[.:HlF|>O#Fc_mL**UK('Ii^G[hn6 N/!1inN[B= !e/;k=557Bu*k0 $ÓhmIib6ܼq,[@ #9YñM|2룈AQ|Ԭ`ka!uu(?2ıS[[RVŋoHYIL0^+Æ-СOhi)G! = H\Aɷ߆6MF" Fi4NA7Knl'<,A[}tm-NU|#(4n 9y塝NqȲН@MAi"1Qe;8;$)]n Yvmԩ㩭 !v>4YNCRrsb߾ᣩwj$*f.>Z2 tc]GBB=먿MƏ?ލ^nwlذ.ŋ ZfbN 9<®]/znx}1>%@2rStQ@6pOhe/D'eDGO&:z2MM,hX?RF_h<P(+ۅZ=6h=n#BuYIv7OKZ|CDD#ui݆{q I3 6{Tif\4>_׏p{QU~^6aa7|pp#|g'ݞE|_() |,%*j2,(/C6ৠN+ǿ$ ֯?q(Gs.̞})"#;{/Pe=7juSWztTDG'rURؿ6n MųkW*UEE7*^s׭+C (dEyqCb70Vjt[ڌ1`WVͶc-yHT=UAAFvQQűJa͚ظ<O?b=ݮYB 㱳iNtРQ3/qJO$AY|E(6L&j̊Ze rr1M 9 F5--E鴵E6rˆN7[hj*d-DEɡC!|r'&T*+璝} Gp8ַ nFvǣVkHJq]Ftt;`:Çg۶\իQl ! _g׮t3yĜN@3Ryx6BȤ zWSWw[㧟S".u)q/">>?g+HJz^Yv5`g_/vjϐ!8rĎ^8Τ G6[1&SXYۉȑ8puK CU՗Me\23j."jAQ›onv{ TUtB>1}ͼE!Cy C}߼ueQTy~$IT|iiEDG;k|@z_C^ rsÎO~_ IExBrrfs=K6{^8/E  G!H?W/De{-{](ii)<il|rNMNY]|>ok[ñAy~fZyt5JE I* sAeep$ cZm2c6ػ%ߢVDCPfx⩮솰֒%͏`2}ۭddL:$ J")__t6x2;wn`ܸqDEZTmCt:P4p瓳c9Re^ 9 22vihGxx-wعN4(ȑYsBDqHof;@ff \J]DF**Z[3j{{/9;y

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RORI^wT=xã>|J:]%%pbgpTƣT:֒~:pO/˽xz2K5^Lez.k1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT ,4s $D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D LM獒iDyeUUqsI>`PQt.0qep8@ x``YϘ. <,xI*egN(*@e,m:.]EJ ƕ8q.Qqthu&ʅ40*LCCKeB"4H:+Y%1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@???ƾ$=?U/@`94D;@?@?@???@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surfaceȌPNG  IHDRc IDATxydU7zKUZzE-hFBlf#!1!P1G a f<`@#-!^}ɗݗ߽G{`#"DWQq3=s%%/;}$GL888C?{݅ EFg=B\"%tҴA QU̹tʘI x0;B98xe3d<8a[乄`6j}߹eaN ~4ΝUx;?>Je PΓtΰ6s|$2ȲE #2 L$)?o?(~I2GG[\SO2$e1fI8N_?pa6ׯ?|cEHRYV.(릸nJQd<=? &?-j6: \Cz>yh^MFYVx,Kc!B4y{~k:{$ ǹg4 z"!}H( x|: ʲ&p׏q=^=gy x1Zh4ME]i_=8N( [fYVc|'<EPL"kiȲ˪23vx};&I4VV u coOx-_)Xe$8G$pk^N}^g>b.bEPYV"RXX0cΝzC=͔e]S "IB@(&$(:Q4$c@׫HRo3| Ahqp0c= d<q>o|_E 7|JaF?GƔeIɤOFzCg08dss0!: byF3Lc8,K= ]W`Z:$FضAnW'<*#?R;>~~w~2YQ9 hh4I!,~HFıG}(Je0MIRʲ(2$4$AI! 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IM~~ U5h6amg.9e{7n|ɤW ]GN]g<;W*q1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT?4$* $I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@$          x1 *\dT=ns\9S3 cdC"YqS31VgM;dDK""Ȋ3YYZs*njUbq,dm,<&,.4.aL*i$ăqR)R) JԶ Ì.s6{vsֹdDAÁ(2ֹs}ro{}ݷ7o7+m5Qs9wݽ(LdVrܗTDDḺ"'jfk*3jf&ULȠ D&f&kպ3/onִnT2 dyy<`* AhO<ɞyy&yL&{籌<1v0Lkx @Rfj3u ne^ܬdUVk3s333j*f*jn{[6Hu`.:8@B,psGG^յ8))JR .Dt(8Mk[Z-H"* },=kIۻ~fe?mo9s)*`::@ysx6 kr"2,$*%& ݬD^A(  :HAhVIơiT#⡑rr>ͼd|Dj R !ʫsNA湧RM5 4ʑ"$.4$4 !@`$0\ t rV&$̷5Jjf!|LMDDMMe|LD[&&bjffjf36s뜵sԓT=ZPc߸䘑=̩ݽ̬sVҫJR"A%(AIš6}5&,4 *aK9gTl 4@6pD9!Pl@ַ5jMտ_z B32XBBm]jlDD\CCȋs!BDA/1C@\RE(ʪ}h9i}>jWUYYn~U{3\յRT>&55}(*effUVeUVVkڅ{\bjbf#- aa3>$s3[njRR ZڵkR)KR)R9IJRiRP5(A8L4M4T¥J*\R# DEĄƅa"!#AAl6000 0DP0#dL08N4%'r׭g Ӎ1dlksSFs&T$ȸmnܩ)JRhPoEaݫj_lj",x4 q4 JjRT&kmffloI@T?w6PRFǀ6*%ʙ{_mkZsk Jqaa.T㐄%)J! 8("ᐃ\S^mff]r5kT`xMs\׹kֵsڲܷk32_d벪fUfmH pn""%3Ymr._o{ܬdDC a0 @DDDD瓈ɪ٪mfeen ؀AqfZYk\fmvwo}v[juBPqqadkRRKR% IA`LD6%' jSR1mK[\HG@usqr-k-/sr孶!*4LD R-jJ!iQ 0ҤFEEʕ0"Aa ZԵbf&&&jD(@(7C`Kct8< ojԕ8㒔!9qƜT&8|8BT^1W1ȈcfDMlm4\&`aʌƄF0DL (Pb(Xb ,Pb(XB ,Xb,PB (`hBB (Xb(Xb,PB (Xb,XBŊ,Pb(XBŊ,Pb LM獒iDyeUUqsI>`PQt.0qep8@ x``YϘ. <,xI*egN(*@e,m:.]EJ ƕ8q.Qqthu&ʅ40*LCCKeB"4H:+Y%1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES1?333333?333333?333333???????@??? 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R#*zaO-&N_!ʍB0h>CCK V%VrԱoG#P@Xzd' ?(53kJ|KD?˖F-=AU=sS7,HEEQ Om?[>JҹU剠p'kkl@w8"U܌㴃kdjIs+N cVNx74]Mtu9/$o[ˁ`ۉ x$\od:'<]OԲ*vF.QjQ2ɉ$toPpDse}aZ}l2e=0_cNӔ_]/j-9zcG%`?f@<@+Տ3N_ (|^A#ArI# j{z>XjNkVn?e<{pU66ɼFxӚeMg`B-{@u;_qFž`@| NfY2-t!0,f"m@M,7'O6ߤ%d%(v(5qp#W6s,!#V$t/gzO+Dlr8 >hf|)ZkcC}4B3J +}@ p44?Ta2T; :I_4V·@}Q+\]=6 r@T;pl2,w’$,P%N힏 8F[SRr}%%<'=Ĕ!DK 'B'tpьO17<{ (,A[[6p8 9 = v rV4UL3Qhu4Ьi0th鐸CN5'N H:@OSQIDބJqTCs[8P$kxXTOeK=QՑY_M L+Rĕh̠GX  ʔC8s -"G[G` fda2O] o'PyI =ISH3'N h̉ BiKw ~S> ؠyW9Jl*4ݾ=|p9 X j=(·%u*8B*Y‘j>~ 8zD3A7/}c|)wz%KNě`uI{n4D칀D1nQ喟'>ݳ&  { +"GocY94н22HԩSz@ӧL<`(w F; |qg` os`l*igh 11~(ZoY)ԑG^*WxRcp*:Q΄? :qƂYL;ǏZG"ds}a>7F?XVOz KmQ9i:˴ɄL̟Aʃ'U'+ OKio"hh:1I'.6Wkp49쇹ax||pp({4#xhaFtNBT ~<wsKp:0#7=}o,ݿ:>uwR(DTB -`v1}9\$FIW0Ho^]K҈(G#4j&Nl}aܛE6JNWcDCZ`0'n]["qM4FAaOw!Z,9T*YR,YI=i«  Bwcu6*wI|Fzm3Re7En݇wèĬ3)]v 9F}E &y4yZG͞s',,t4Ρ}ލIT,AO=3XOK)F'Q_x&ᝇcpݸ9(uHug04E.@̦NkٵUWMvf[-SF B7r42&W2Ba~_j^[Aڭ! ~mAT?8-tn1ao pt0 gΐ!zm,܍ ҩW\c)0N=Pؙ9I"ڗ+ɂU !+rh>m{[o>1@앑&x\.\.]&֜Mϝc=Z) f~vƓuKG ^ɓ\5LCWo'=:RW9f"~t7liv trĴw#_^^XH&yJw ^N_w|9)BۍpSeQk 4P9bqԛk,1,dm^͗k+=Pgd7NZUVBa)}?haX<]G?*"# k Yi(N# Ia&BR7ߘ0] ,ņqøD4]6P1 z<87WaF{57T eѠo[ B%4[-VQ)Zd4qq|k1@1'#bE,_{-y_eƾ 0ȍBIVxag fdppr" pl@Iw2PjP}~cCk. p䵪܌B@AJơsh ]kOэ($_ HW/q* |  #}aGBV]+ BL#ts< 2=mʡJP0R겿IQ$jPH$z x w7?VH~r||;y=sL~t{^zWq۩0V*] f(_: en[~taI Jɕ%%@*l )'T.!Y <|mc)^ײ<}]dW[VU;m%"㐽e3G?9KVnm@#]iS]gs^&gd:&F\yTI ɻVz[=އ\O(l{rǏ{Po#Gx TVfqkj4h&[\k j-~vzڑH) l]1FT(SsяIfF;v00?C(@#%GX% 2eU.d@La E]SYWM1vyrH(^Ά- OOjv1Ԋݦ|q/.Z5:XǏF=6{zc<yMfv?e Z/h<3i)?/)[#9dZir/X~e]Ls褁aSL h4K@y+4Dr^:&bk zR-\-+LC^!ろɉc+Nkv<[ _UI4){D6w젘k';"3ş}:oXPxv &woa 趇5EE0c,\d?`> D=w¸,wA< axM)y!=Pl`~ dh@e.r84 h|l,d|F>ey|" Q̶en3FEi|ļJ}샘sv)y~윏/!T[c中AB1:.Q>rZ}DWmQ.e}l`Nz@mNy`ԲqH,tnV1Pp>@hotmt6Wc×j4j O@Q8-ΗkKCPk~riӲzӅ+ !]/5z"x:{ͅp[ϗHRR23GϐR:;8w==h4 f %8fjf qE HP4E`;I$Xk/>9dIF#pl-|ݡ$sdW4zDgDn@e%<T`\U I5I?3rLvH(_ %mhqOvn'> Sy 2PKAɿ+\nI ׭;Hx )\Es"*xIENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT:4$          x1 *\dT=ns\9S3 cdC"YqS31VgM;dDK""Ȋ3YYZs*njUbq,dm,<&,.4.aL*i$ăqR)R) JԶ Ì.s6{vsֹdDAÁ(2ֹs}ro{}ݷ7o7+m5Qs9wݽ(LdVrܗTDDḺ"'jfk*3jf&ULȠ D&f&kպ3/onִnT2 dyy<`* AhO<ɞyy&yL&{籌<1v0Lkx @Rfj3u ne^ܬdUVk3s333j*f*jn{[6Hu`.:8@B,psGG^յ8))JR .Dt(8Mk[Z-H"* },=kIۻ~fe?mo9s)*`::@ysx6 kr"2,$*%& ݬD^A(  :HAhVIơiT#⡑rr>ͼd|Dj R !ʫsNA湧RM5 4ʑ"$.4$4 !@`$0\ t rV&$̷5Jjf!|LMDDMMe|LD[&&bjffjf36s뜵sԓT=ZPc߸䘑=̩ݽ̬sVҫJR"A%(AIš6}5&,4 *aK9gTl 4@6pD9!Pl@ַ5jMտ_z B32XBBm]jlDD\CCȋs!BDA/1C@\RE(ʪ}h9i}>jWUYYn~U{3\յRT>&55}(*effUVeUVVkڅ{\bjbf#- aa3>$s3[njRR ZڵkR)KR)R9IJRiRP5(A8L4M4T¥J*\R# DEĄƅa"!#AAl6000 0DP0#dL08N4%'r׭g Ӎ1dlksSFs&T$ȸmnܩ)JRhPoEaݫj_lj",x4 q4 JjRT&kmffloI@T?w6PRFǀ6*%ʙ{_mkZsk Jqaa.T㐄%)J! 8("ᐃ\S^mff]r5kT`xMs\׹kֵsڲܷk32_d벪fUfmH pn""%3Ymr._o{ܬdDC a0 @DDDD瓈ɪ٪mfeen ؀AqfZYk\fmvwo}v[juBPqqadkRRKR% IA`LD6%' jSR1mK[\HG@usqr-k-/sr孶!*4LD R-jJ!iQ 0ҤFEEʕ0"Aa ZԵbf&&&jD(@(7C`Kct8< ojԕ8㒔!9qƜT&8|8BT^1W1ȈcfDMlm4\&`aʌƄF0DL (Pb(Xb ,Pb(XB ,Xb,PB (`hBB (Xb(Xb,PB (Xb,XBŊ,Pb(XBŊ,Pb 44UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT,"F8@@c$2`s*X|\t20@D,24>8F6D<8,0 bPhe $`yE(XѠc.`"$\Hpxx" 4 @8@6>|`dcCCg :tRJ(4`xTH\1qBd˜(lX*$Eɝ1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@??+1FJ4AfffL?p}'+3OYTAfff333?p}4?{{$?? ZG0 /?@?`?`?`??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1 PNG  IHDRcIDATxytŽ?==fKd[^ &f BG#!Y!&<&NA\rONKr$`` xwɛ$KӴ(Yj K@PG8DߓJc?fC"~)Tr6$mۘ;J}NbweJ:4U**&&vI4>;V  x{ GDB}F46qT !@A"Z&/ۏ>"k #0hH4H$"# qĻidr\+p'ƔƂWS]~ xZlKĮPЉK݈4{B*#d-#=q 6'jæ8p>PO_&cz=:ֶ'#,STN'Nc멩BmTf"TՆiVUy˩G#Ds!`sxkV2j8@]4 S4ux\|ռIbל8nʋk2lRJLi"PU SL_FEiiv tqxzJ|Gf+3v\Hi"Cs1EJ/Y1h8RFmԌkbc! '/κMfx~t%aVX(1`<LN/U@#D(uUS?_9+SHĠ&F j$y0*:miJw_6F̈`S48y1s_̮t駢G>r̀x,S[[lv(:ኒfN!9Aw_vpԏUQ/(>ϯF:6V TUh jφLZ*Kk(-dq=^z:p9K{Q@i~?\6J3?{BMŵ)"ZC2^oeJUUOdWslO[Pmvaw4{# MS3?06k\"F*Jje>@-63qy^|NS⩢/%`\\wQ)BA(jpX~B#W9{"AԈ z zz``|/2kNy3b \-;ʉa4@_4E7bČ(KD<5X< [#HX%w%}c:3n+ltӻEc' q]k|GAmOZH0"G>S;7tD zq;KU@빶 %bFh,ncS4iqY<՘i4##>t#DHȝÙ07l9 3k RC`Q1TՆ/%G>ނD]эđHN8ЂMkI %XA7\`|hm6}QT5T@&:S=+@_/y]6V#-;4M_'ݾ}VɌ޾vkˣX,]saJpoE9p Bksc( ۞m,Z: XSh,;kF% $b6vWE1p'1K bz$vʯ~+|IU ! 6pgFبJ]4.SR𼞤/O/y?`w_]])[`t?9iE{{;---x^~/}\_OGGǙ-ϨAQl̙z9B6eL64/._tv/ç>:pØwd[@o_/={sl-GAΛ7uUdeidƏi)K) #{g5k_|_sQ2~ <ֱ !BYĪq;;m`2 oO?NO|>/#`7hqrSғzs|tvv~z 7[\%P$p)1#_}s/:{n{8)ݒAEEQ v4I #o߾suwwSQQ1}yQ f֔%5LcF7v<|Þ4rg|N;5%# b1&9Qƞc5Fs̆%HӴF(4h;u({z)!]y啼IQB*́]sP}%%,^R^^K(믿{S9z '͑iȋjgcnǏc=6-'K& EMTV 4h=upLϜ9h4ʋ̚5~;0͞g3bZ[[{8x ǏO\s1o'D{5/C+Uh4N^b UE /0b[oq=)MkϰzG-$_;cDO<oMhk`<%/cSĬtV8oͤIN]"k4u {6 K/Ě5kFOŁiGϚfs@gVå?Q<,Xlڴo{7G&NYq!-3*S@;ɯJb,gT<3.Zd- w|:ڶ{i|+#_^RZDbU]zT#涻i&׾F{ĉp kNb}4 ƶ {n۶mx!y衇$ jYVM+P'6nȇ?ao+LqOڌI[x n9Oɛf$HI_:>(7x#;䩧r յtuuQTTr4dIxsdb&ͭ0M~L8ǚ#$*;~vж}/K/tFHqJBAJ2xwxwYn]Ϟ)^̤TIiE‘_o`6斝4좹eR9cӦMl֕+W{Yl r޹yYu|(ydH|L H݉c]=}>m{Sߛn kk0uͯuVnn:K3&{g?3G?ifAӕ%1?{J: h,D"֐ƫ:"g1'>+׿U>6olL]67))>{zX~=+V Fq:|Ӏk+[eDd rgp; 0P9b9e3T~oN[>*.g\nݹ]s1[ӗ8YkVn޼Ym!rz>xK۫9'֚a 5"=h7D ^ñzj~sYLuյ_]3v82蕸 Ngg5sFR,䭘+&zEb5}YJzDl3:p/=1eׯreaQUh4什ޑ0Wk" P:Jgߏn8x5{|Jk'aU$+0 XAg#&ߍَ"g1KXBuu5x8ʡZf/7< T{<|ҟ?$,j$znxԢ7 .!U)&h {-[F]]{e޽gkb(R|ϐቪz#tN1]AN~t٪*9 TV<8.?4I,1wLvnߛp0ɻd|7N `Jv{ rTLlU7*GJ7Fi^#Ω̙mg55c9:Y-yj, &ff,F&BаQǖ-[ ]y/(L(Bɤ LH4"  Bp( ;v yf>T.u)\vٌd0fզ ޾v\b܃ s. O~uWRp2==zz23/[/ >Тa91vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4y UUU⪪??UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$H  B*UZAPUZԟZ?B/P PZPkUTH RI ֡֡_֡kk_ ZZP֩?֡jMjAW_i֩Z5B/UWTԟjZ?PZUT B/֡j֪jP֪֤ԟRkTkRjAA B jO֡kRBZZZB֚ԃ/I$H$H$D"D"DI$ $$H"D"DH"$D"DH"$D(WW Wf#Ltbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???s0(s$??t0e:`;7B@?]8?]8?]8??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2IPNG  IHDRcIDATx}xT՝?d2y" D]E]VZ V\HӮ]݊[}Z+Ot}TE !!ɼ޳;w&̽y90sf99GEҸ\n+)%p$8̚xGf!uv݃Zh@K°Lfѥu&:BCJB +!J<6\Z>y93#z !-x !Q.ݭ҉DCv3#^FI'[ip!4CHjKխAKyH흡 0bFp EDB #gsW.籍Ksi.2#Cvqc&Ob6-bӄ>BhhHy!eSB4wǀ\($kUu {wj'Vƫ5=Jc˧7Hu'r8 Kyh MRW]R?WiІ1}bF'YdI()vxcϟۥ<6B3~ą?m 񇗀H(:hh:ڎV &"l;{ yl"fQo yP_uՆ8r4rrX.[HGyH VS@Ϋ[yl#Ҙ1LWe-ğ|F2F[HFFP-|r%3b] ϰ}(o1{*(GJ<3.pɩģzR >]ɣ<(l|cxLغ^gp[QJixX\]xF!3&3pЦ3ʘ>33 I*i52}r9 ±BZ򪐌LQx֥n&F8J ۛؼbt|]ʐHOttyF(%JA@g[-ɱl32Ƣ>3B4x#bc%L?!4::[6P‰53B4Y]y <8ȥhQ=ەqHy`]έYիWsoyfvy.~ʜ Q}ɒ%̟?h4JKK {ȻpB*֭[TٗOEQ^^/6rMuu53gΤH$B4͛`P4n2 M-6;v  xرU^ufΜ i=~ m׮]466f.VWWvٽ{7Y***eL'] m<=CGGwyg&Y o\%L_yz3B}}W6-;ƣ[j, ZLMwٱcnK.ӈ1AB(/ԿR.}.~&rsXt)u>vYøW.m߾l^z%.⮂x^<~;蠾뮻G9> ˖-,?PxY%/IdrLƘK$‰̙3<.]ʞ={X<.'ؼ@ͳ69ɀ1cx8tUy|/j/ZǗ-[FNN555# H4lkNSc8OMhƆmV[Ǐ0q*+fM6汄CD|>uuupTn ܹ'|M6h".]J4?MnXѐB-ϓ<=06C-gѢ|Y=| ]χrʙgɭ676l`ƍԠ:P/cƊ‘`^PG夥4B>7k|`?zJu۷ogu]l۶6ԄG]~Vf}$Tcni)O>dbQ9L.>'>g}@ š5R`T{Mf3~dm,˟H~~b|gP91V |8L~n?{Ij @Ja?.ml'>ǎ%u5|c'ؑSuLO6.Hp8H8btp%6QPJB1؞H`J.c<ԍIXb_HoO+CvyFfo:Iܻ+/&,;eϔ$YS?%mO*Sh#ۛU@N=O\tgVjo.]wK옱L881at3ӧ5V_6VټWVf9Yyxt7Wp|G wf-*%=6oꦷKKj~K>mJv]nVQЋƕYF7Hܥc˕ѭBXHx@tvbNkFK806rx[ۥL'|GC`c[gzz֯'A]^NfFk|em]|6 KzL>#n٩KcHE1W ҽ2imo0F~]h iL* f$ZVff&r +V2ʼn/[;GbTiDG؃U-%CB;~!&\RMfzeVf zS}"}6)B&n0nkA%} oa"Zl1B2]yt+~Mh#~B HH4L$1VҬő  w&]ΪUhlLe\TuNgGmBtCB+cOz>(--MzsrQ)RכogmMt}>><\Q)] \QPM8boHrbrdz:hh$'[ޏ_Q)_֐Nvvvys /;Gl/YFm{G+'N3裥Ɩ|tI<{ ^c~ɒ_pY+xu]\.7p@O7ڏLTS41PR8ӫ@)ycɒJ$1{R' [w Ge*8nxJLD݄P<!sWkxsxTYh4bFFÝIWO}36lW\ _ز8r%l}'O/h|>>()fJ,z /.Mè p'HP8@0{B36&?:Eg}6k׮`;_>OpB~DN+I'OAst5͑P${6q^%\7qcvIEEfG;F@+ɜiC)֓Kf07M9{Y kO?M`xؑVZx wJ7F_Uք ْԣcq;=T7{1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT(4x UUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$J  BUA֡**UAJ PTI/B P _UUMjAI'/ZZ֡Z-jAjBZZ5_֡Zj֤ PU_PkR_j ֤AjUS/ PZZ_BZ?ZkRIPPAI_/ /?ZH? jjj ZkRPI$H"DH"$H$H$D"@$$$H"D"D"DDH"$"DOW#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUULtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???$??+Gf6+1@?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 33PNG  IHDRc IDATxw|չSz$KnrM68lB3 ir $)$I^ $ !1t1mEr>Jڪ3z̙GgNy#6gA GFcN$‰L/]Ȕ*бeFidsq:4jk:e2!LbZ3|u7VJ;~5ǔ!I߿"0&BXm,rOpuQ31SQ'OP(Fs"hF Q.1-@UҧF %'E8Y0z6fx`1i8i꠵p80Mù{ߴ F$ G&TwE:bxb0PX ]wa8 tC!PUg2TM̈́-Nc| MgliJL D[ǂ6nW __|O>ضm`0e>Rx`-q-S;xWhzCM X>2 22$!HAc;+֑^ah|oK?6]>ﲌ&C,Ɉ.W!\2GS;<}Aӣf'P=BaFQ8 Gi Twj8 1-";}ti.ܿ4M$IFR6k GĻGw M4#R3C TOsTƂb!dI߮k y #ݖs}Ld )&Zb_, C{veO߾6Վht.к r'jfvY}Y$# >U[p쳷 ؈/15 /3PՏHZjQ'^O7]_zsq=;~ù_r$!IGk1tݞ@Ývhzq/?+7Է[vq*!'t_6iltCX҅ffTX2p.~;\.&yiQݴ/@${&0L41M4ZkFا{N7Q(鎝PtE4$GѴ,s8sƥ̙zv6P6V"Ȓc`˽ŷ2z8E=fFc{er6(#=ߤꛎFUNs]ֽox݀`6O̚4_69dtxPd-5]npwT<ͻb„"͖e@ #2 14lۀ̴|r2 J/eA7P]UQ)%°`LEchz*fliȊ:"{csg!ӟG/; Uq" Ra輿ueSbeϥ)xjrKm1Z{a%erN/ '+KR918Tg((1mc2 G8fm̚?C8t%͞@><.;*~ rڄO1y̼zCҒ2| *Uv(7\?O7j=]Nڝ(6S ;2s9dg1;'^N'@UTm0?njI琝^HAXL~mDRQ0 7'inwNxGˀnv@O1|H:Y4{]}$iD mڂ4v.\2^^ CeN1{Eds$5N/{\v'QtYV|ᒑw8"nhըf~q˿"0t$YsV2&a{aj)κ4_6sf/Gl**\MM!$Y& `:Bx~Κ}S}ow{üt;|'+ ˮ w<n䭍mw^N/xPQolw1PםFCH,[>.OͺJmdtq.Iyh< p8nzv@uRiIp;XM璓^@vFW#ßk  ӋaɍX<;Þb`?b&%ȁ#:R2Tu'&Ŋ$n?,n@c!P f]upqLGTEnhꚺljҒ' ˮdQUpj+ٰNJc On)ܔMJKӭ"|L4"ygaP-h"!܈$A\iݻ:YV.\p=`j+xU]-F݊>P#5u9\6RY#H ?$I4PEQQYQQrF&]N1|{)+EVݭa:R7*@ -z.!/] JaGdH $;PMXO}SW@i PXݯxj~*A'& +x.pPZǐ^i!0غM} $$$YFd$a)LZGXhW\qw}ws˖N?4_6$aFZddE%Tcms0xHH?N嗟'i,La:P=<|򲊅ET*wvYpLT[ o*k{CDSg3Ғ9Ȳ8%*A^̮;CL,gػmђm8 U] >ҳZLyYVhgq yjeeYAd|Bjd2{1&x8ۏ9~ 0 -f?1ZIcb k\'K N )ݟ+ZC"3-99xmΐcuS2lM!K2~odqQUՉCq" BPV`Z8h,H$$kt{c*8_^^璳x?>xp,YK ǝQQҒv6a j0U#5{=p,HI"a(R}t_Nr5͛f ~)16BV$bhh$)D;GI@8GU{ʸꪫKa3S0]˲?@!pkZtr1cBuζIKco!i&dh k1Ye\t&r{bk֬IlEfBf‘@r?|m80`i @OBh$;O/|7:0LÍ$)r0كky]}کwZꉺ O?tT<u֗64v?U<z fL<[KvF{'=^`m"ajƌgrrK!X7x_ד޺#[*[JK8}ݶ g^w:09xt{o?{[fO9E3(̛&[ϳΛ@TJĂ#Mοg_Y,{R8`} !8\'Yn֤l&`H_.qg<[BC TTmIOw`3%׬}Ouϛyp|s=#+WpPOxLU[Fh 5t`kG!IUvѾ5ܿSn~zɲ}((ܼ'ކIc撟]"pb]YQ_ -V{wozWY.J<˱Ed&/td ITj'K T B%d9!"a:K⣽ d@$&i s'ƓZ+2P%z+"~kh>FKkڔL}XzAy_)# PxǁҒyׂ|8\W ;xdH 08`"+{G]O, &{uwV I' W;6~glӛ5kt哃]|̻ Cv&O$8tl'}I PhѴ8u#Gϲgh(%Kv^o`{^PSEh<*9Xŷ<8i_N(DJeSQMj`wrU a͚*ꦺ9tl'/q-fh1e0+6@w$z.'u~HڵGO#;0l^yg7QYYsANp+܄nh/ H6VNEmc;y}_4pZz|q Jb<f*IPf`~9:cöVLm0xYsW:x%5#͛egc;ٰ}5G7'EѴQ$gfcJu>>s5~,FQ*+7OZ׮ m/3UXŇ[S\R]j*^ziS\㩨ڂ!tZji 70i(]~Qyl'1-B,%8m=[큵- L[V|sLʼ;K_UG{P~`'7YZѣ3ihRUS px gܓ82GjijJcbq[9( -Lax4#iz ͈dOD& ظs5fرkuY,]'OCu9֣ jIk A,YjABг3ǖnq*nXJ$l=RU1 V3Պrwi ߿o஻bԩܕ/{åBvq%p1uLv]wj KKNКU5pDnxCƣoeMz]Vfg]?(-EUe+Wȑ#ܴ|o?8Auʊ$xo뿐%X4FNf1|c8,O9"}:}l͞F _\@mY]h(?61SeZcLx|6.!mӢEym+biIE%/Ӏ{_. ǎm<.?Cv,[Y?OE'7'dvIF)_;dp.|tlb-&t=$+=t..j0?/| ddyR%'s5D;4%e[lJ%eA5dg"3mTxpx7… 䪫u}'î ݑQ(JĨq wky檫3ׯj2c Z)8㇂s J,nͽ^Ğ=59ހEPvOBRr?z%]2Ĥr=c83gbҤ<7pcg8igFb) ݈& G(bstU9MhIr۶\'e儔m1rF$4d9X(VXޛ,Lďlx]wvqGNE$Z, s' I2R6y@{~q:?1fm;44XjjfZ7 +!ԪacwƬO( d{km&ӉE\wu|{}K6*tyyGyd{2 ' H{-~? UU%+ %e!*qO< >耴0 hnNk֬i?yay뭷0a€dA]11X0_!@QEA$B w";;xʲn~ӏ À hn杏>✲ev<_9`{ Íx!LfN$UřekzncÆ _zzl57CFsU愜.ʞ=̙3g}->tEvqݸ=nx`0_W|P0Ã$IXߛIVZU5\wʕ] -]U;2U_|q;M6_?}nF 1tjXZg -`[&}zl\7M~L|j Z0h޸q#۷or#v3OcV؊躎M]2oX[^<#8`} yȫ⡇_yg;M6qM`C!G>[O=IVY:aODz#ZuQU}G[W~sgp-K089d3s" D$@Pq T]qˊb[n8Ya"Z-"';cduwn)0<gWBcap5EċDaeᚽOc3nZ# ]cׁ*ȩ5nL$ß$IBLʥ-<. 7nHHrp@ `'p62 70~UZ;DӴE7?IK#['z= 2W̜IYy^hV?`: #X+#!a:0^=gLdsشkijlV"Iɨ)@hnBOnh= ﻯg8EȀ8JôZvG{-ׅ%4Mꚏ${#OGoFkү"0qNJ;o?91Lp,W\ZwMx~l,1uzz)nhfsn9& Bݺ 5Ǟ---I(ҌLs:K0dNk[N3$t#Nc2[˹"[L3i{.QQ]0 5xCe2NB9' giY^DbCs{^xe)3\m)L}=O f[40;ðkS|zPECQǭtOÃ&hݨ>,_o0XT,u8lS;dELa&NꛏRxCԒ c,(V/V} X$?0~LZfˢܯ"a j&f[RMZr0.= )zwj p-🛾q%LmG;Noj9g~+m I Yg&/}2I]y`mȒ杉)do:1[9[kH-ǟl-FJ%FvQjkYijMVab"#K&BXdEr?s5S3D˖H>Dd6 lM s xr6O=+NgP^^˓O~,tLVJ}ѝ1g ǏZ36AREclw|幷'{vΨ $lڝ`sOq[u+rJ3WmՒ 3x3 R;Qqy'۶}|A}}F#ݛ:}`C:E _+fUh808^+b(a\t" "MФޓ(dGT|S)~ΟL(VCGG$L!I5;<^ 5~lY:;4pjMrgXɥƓ=aXnV+R)>?y!d_o82.:n<$DaLJ)(lׇt8qݸ]L$Ukj8^WM0xF\^B8^r5uV6a1A,?#xNqp{}[P쪟IENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT )4z UUUUUUUUUUUUUUEUUUUUUUUUUUUUUUUU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@$P  BUA֡AR( Z֪j?PZ_֡j]T!_֡IJ PkUT֤ԟRB__jZWB֤֨( /O_ZZkUjZ_A֡kMjAP UU'Z֠?jOT֡U?BPUJ?jPkUW _UR jO5 5? [ZZ֡Z'P֡RBB֡kMjAj $$H$D"D"D"DH$D$H"DH"$H"H"$D"DH$WfW#HOꪪLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???$??@K@b=@33<@?´?´?´??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 4-PNG  IHDRc IDATxw|\ՙ[jFu[܍ .008lI6K BXv7Ɇo)ĐxaIB;7l˶,ے;3,*3#Ɏo4ҽ^;0!JvtxعӀם2oUCPIwT!5TW̡UyL0( lޙy.|7t_vu,= N^t*m4͡CC̮(Jtԫ*KcZ+BgNa SW(;1!3{5}Gb~LL0M*K!Hgm[/sfA$ZDq K110MIX8~YqMeHFؾmvտKGa:MW[3B3 (vhg C+F}Z;|G#@]$1faK CaMwwatl0fT/df~i}FKqo9>o%.'^ꨙ4Q-DAz&VغgD_K9w ˩($JDb~rQhvw^A,+Lc<.߈ܱo#ôu5up/ q:_U>9c 0KIRϩJ 8bߏa)/iwPvWY<+θI' I2l+L{Im~aVb \EN[/X./A%ABEDyI]o~7mJlfN‚4]c?@>+-3,#2H'P;]ؼugS\X]v7kA>yҢj4 `- Beoږ\rY&I:'/itz۳a+Nidl El {uTW̡WEaA)v7*ka:2_ejop[N+,[v XϏ<>~f4jLm8銳4 5i^Xܱ@$[kQ=%%n֭{%* lY7b Cdu躆k>y Fsh#(ZCկ3yb@)U ~o|tVu[aH-=iY5)ЕoSࡠtpXnňE#~::;k?͉CEJM1GӒHy̔L 4HmzʐEsNB/2FK[Fj<&vQQ9 0s,73ُ(Iר47bUEsG|HRnz H);tMWPO`H,H2#D'*jb&(#K6llgRe5jf2kL^ﴵC-Xy4]NJ6l+ο?(Ifb躊D!N/50; ^tàpO{ơ-UW!頡i?e%R5ik.߿`)#aOBܿ ]We;(2f,s)h`…gH ܖ-*"XCˏRMm{{#:MhM݁lCaO_Ǒwܘ[ Yg6^qv_-C\>tò761q9 k]ځw$HuPZT5vRװp ш •oٽR}Q͚XPyHkwڲSQ#Vymϣj LetహH[0u̼j2ߔawyf :r8aXÆʃֽo"bQ(r-=>$1 RȲ 0%dfct@BR^\ӷZK N$ qn|Ȅ)gPyaB瑐2&-r T⨺.&9H$c#'#C}m :/5{8]W{8^9,e#dl>~F}1IŠ_-zs &EK{Y/Q,6FDbG"Ash/8_97m/!f\a5qr=FՒ!4]D)5R"@/LC6%Mm{C]yrwOj=5zs͐iC2f巆ԈiZ+ַ<>>h'dVx$QN1I-]T:j[w}7?O`['B$J Y] T- |1\i;&p3Cδ{k\~myu`l3#sW E;\;Gz3DA \EiR?S^vWzyg7o[ށ.NÛvr?l~7E EMj &cYy4m笅Aƻ@5tzm|=O[߀Yimoh'E7QG@V@)sil͜җ֭[7,Y[#"6v'wOE ˅o̝v:6y*3 wY%uMS 6̛R~ q9\&eSF:įfq^eԷXtJ,&"n#n#"n'j' OD;̞}]9N_p |R7p>5-(FOǚa-aff71 S&jVݯO+k=V5EM`99}E|+ vYWnp` ]ZslTx"L<f|jE |$$Qiws}?2g*J'S9$]]~y曽"I5?&x/ h dՋ%x7w2JgVP*iw,cVb&Π‚bv7? 3C7-56# رocZFqQ%.G!ۛ34\ng!eՔWR)EWAU5J@DB~e|9W7 Ú[ @ZU59LKg=lGlȲsN* hιlۻMW1zJPb0iˉ4uLI^\;ȲЉƃ!6~ŕn jz'ZJSGqQ96э]v"I6T-IR5zK=͗ "IRLB$AWzSyL rQ۠SY,l8{;iιӈ|5TL.UAQ>ɼXr%?RK_!"+® vu|y+Т0} N{2nlV>:^^q ݻ(f&@at+a!V߾>]Y %}^v7oo~6Yu-TMC5B?VVqqp:  DI$Gc~lMR N[AWyrD1{)Hcr([=;QkfxB:Vz<k#1ky^ilwþf.WiQZvb:&hdP/p{1iI‘hh'pQ#I<iwa9Yqy{.3V 09bn& P+ 6ˢbiIv7˗\lsLIdb0Mm{Q5x" &H*1 d(tx2=ahB(9@4Ziw3or0c9cb;-]4ބ6{=V_ 3f XVz%5^\N(ӮMG-o~ꂿWXD!Z:11Pd7HF1HGjo` [#'#dU9;qd}ӕԌtn.;ۜd瞲&p2L4rbxZdCQ)O߂t?YK#WGJcfT/Lya؏GN%=-ǜ+Ph<@yTv͉]v rfvSp: GDAI,"X.5&|ފ2@cуUnۖ %Mۙ]YcV^ZjI$c"Ē.839{< ̝~KRԛ5+($D G8ؼo~_8N:W!>oNy !2Ie|^vp\!B-o#o2(fk}kɰvzt~8i& HFYodQ11QX˒a)pOD&yiK/e֭y?ZvSS90ywn̎xiIjykOUUCY QFvOଅ#Ȯ>X@43ۜ0~7xڸ,s>6َ9GcSh#ƞ~(`ygw8<<# 6~1<_X He HC!HX<[=>p,Wq$AD /lҊSAHO9\p~1ȸQ S1qt{җO>ɚ^`ժUݽ/XrVf0nޥ#Z)CO>ksQ˘49j'!Hxbx#<ݻ@G6=cdW=͒Vl%DQFeH9V4BMhL Q[$ 6[x@Rq/\)SPTTpZ܀trOz߃;5kp8b1~?tttxyWW yO#v$+4a=Yuf)Mj VL#pH%1MBO2YAY[Mx"'H;g'bu~`D"A ~_Os 7C.0 ZGv 3av2bv'NVjV'CKR]E7g\y=yDrz Yi:M[6v /lV|ϝG>)L&iii7rK?UjZxj Vw]b`di=aXAH)f$s-aR4&NfP\8 .HmN6_>!qmбFzwPPP?2/"]vـ׭[GQQ$q%HF>Բc cP$ %ܹKzK&AT+<. ;J΢dvuuu<ӨJ$! ơCtMwy|yJO:fgwY01r+V0/!]{?`qœ&OFQ=yxy!FX2cŷbPG@‚$NG'N;{M߻/^o 5 ^q|aw#^^˦Y{GTy sO :ރwR ,rH nvv LˋCm` '^~Is`&o鵖) 4A7yQNDlVXӤ}_xS1yjUKHF%©:nH-5]w K6AO,Eٻw2͝;/gݿYr*.dz䲙\h.?p;hJ{W#DPH'ڧY5lm.\B ;Ν;{MWuA 9g Kv"X6ÈGD{ ?nQ$" 30oȒx2LRl }\+̉|yy > C#R?2yܾ(Ϲ{ｗ[n{wPٸq#۶mcÃ7 gIDAT \9LY=ǻYޖ,0 zl"qXVnb8M6wu 裏pu+W[n7@4TUͼdYfѢEn$N ,^<Q5|Ϗ/m-'Xi"#Q?wX~I%.ػw/=Ps ֭cݺu<#444p'XJlŋvP7Yg`Fv8{!yyq&)Z= K/Ĝ9sرH$B[g<׳zjɑϠ:f쳛ٰa䳻-([&&$㰻Qӫcf6 kFw=kq5\ë^'xy KF!w\+,K6í90u$QT8n|QQYY(?gͬ\|z)*++Q_#jEц2x@A2&Y\$8I% ,s^9bEOGԕSO/G?Q?H}}'V-gQQ(/2HJD2\"vORItp']H֍C-mNLL4Mnwp3(,(re8FGg޽x<n֜9+4kx!u qeGiXyʜLӦI%$D)+b1.{aΜ9Y˚-?~ӧbƏx~œyld3zhe) j;A>[s]w7ڜs,v8LWWNJ=T|v=/riXi~jkGbxlKy5A8sC:Mw6p: \Gm??9n_ Ao>E"89`ݿ.ߗ2-lkbTk:z(S+㖫Ǔ;ew=n=~;?Z+'~pq*xKo'@4Zα@0BO4k05l"O)R$ug^{DGogɒ%| =+DW_AӴ!%w[~'(:k],E5I%}]CJ #k9D`H>HH¯q3,k׮e۶m$IgPq6^"iB[A(I88$Mb<3\wuA| 4p |;̛7'| 6xb.r.]ַ䚦VYd0UgWef=N+E%[We̙} tjQ[oeժU[R<ʯexD8kLӄg!lzb@u,\v/4SxRK.P(ęgO[KZ6uiS hB[?c]$1DQ[_Gvَ櫆K/qL .18='a绕g}nM"9k4gLDy!{ҥ3gFR1#cDt;Mƃ#c]aDQbeC04:M8^疞|%6ف)$O[r x B\vm{R5vRXPU F0A,D7tDQ4 v?V_rJWQao!̙v(c XWN0&=r<%E%.YQ׸eeg,FZG?r9Q4D rl\> hhٝj'd<501MQR%MAV3jc:8+&XyW-4TaUS N[b3jegch݊+-oq̰gQMS&CZ:DDA0Lo ]4<5!bJiR/M!n &Rq(PA <sƆ*95Me34R3*UO ls(Oe44C?$HX68 :LpzYI3QxXq.IENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4y UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$L  BUA֡*j֫ZU_Zj֡UBjPTTkR jORAR( I_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$DWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUULtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???$??=A/ v6@?y?y?y??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 5+PNG  IHDRc IDATxy|\WywU3%K-;N$vرc`YHBֆ%h!6‡64І$8`@6e[-.~qFˌf$w~\̽w9w7yγm!0) C#'Ѵ$$%Hb$R1<&0i=:ܦ(ʛGvz$Ȳah>[h}0yw,q$ ЍdHi Ȳ"Tèo'֟7tS`:1 'JRqRz\x$'^*i az:WqيPCB 8Ö"K̞gY:aȲD"'%)-n{qZ_˫x2[$5u@ӓԆ{,5ɨ%E%yh<0}1IxaԁG0vWݯ8vM/a` ԱnM./Z0}7ןb3ZzDb}HL'yLc\i"ˊQp[T+Wȣ?_8CW:@5[;۝7|Xb~S0*@8XHy:LG;Շ"\b"~@p N!pt;!oe9u3mvQSױ0CSEo4#a%MV,ڐụ/_8"X0i}U z*C¦ VzxT?N#io'U(k=lg0A3aNN߰w/! q?ι #'y)Tk&Hkh;q%mI0=AMErɒ@!ޱ.6Bj<Up_UO7XuH<}p&jJJHF9m2#%,ɯ2_$S1ۖD74wHB$Sq~Ĺm"8i`K"tGd*f?!I&LJh"`иu_ł%Eƙ6jEQf5$RQ[(H̳/~']}౗PTUQQU\jۮjF$3%s0Q W P-`eB*U("{%+R$5 SCU$#IY^/XufnIxKnmށ..YY1ng+Onme3LӪ0(~M},zOpE-e?{+hKc\ KYхU(--d W2{%-/詽c\bYqfO<;Ijq[`$82+oy0tN9?ƙt^qzkn K ,튻GmcF|p*!t]3/^uԶg4MO#:$˂[(09r5ϖF'x2`Xb6 ^HmLq$LOwԛ<v1Y޶owԶdɚ5(GG YGE:Ct%cD̅ꙮ^74bc~,i$0Ǎ{nM)pԛxU>OY I+#3 ξX'B.^%$޹.Y7?$ SHȦ$._=zNk;d[:׫mǠXGE @pML8d:}JK>[9f'N&xޕ:$c:skXH֦xsvnښ;-4]Gpv5\!дĄK6Zw!lz i)tŠ%M H!˓,)TVQyx>"~"AbA]=,_HXoĉl @?Ge ùGYZd[7~ʄh#G4>)tijmiX!,=ǫ-+b03,iF@`:ajk^a+ kx 7JJE 7tC#d(֗ Dwt,?ihc йhU4/ Rm]ik39{G~[-iuC#"Kg$p'*B޷qߖZYRpj XeYESy2XGb[$G~ͯ~@r?GmK,t#ERK0륮zf:7]8:'8zjBu#E޻V=%aZ&@v&@1Od:픜jʬE\-k>5@dEWIQLX;ԧ|<3@Vqbh BB8Bq); U30T@isc7^(N4Cs]5ze`2`' cy& k)ҾzљEskÖM#Idp@-IxTm;aY:ݓUW]ō7G?QkC\Xpsm=+ۀy %"{])XDr)[Cc{8;w(q79H7$I|/nJS`v:ζ}3Z;}ߙ_1[]}45HA)=a[l~b |z+{߸?teιYV T 5%*2Jb6_wJ\fGf&pn4ZxB &]rFXΛy"PI8XK(XM_mK3uKͦh oM |N>h@Sgt1xU<%V klo|0MOXmE&g_/:~70y+x7ȃ@<ã’Z?i{nz衜,Y傅WXA򶻡ĉ:پ(eAڙ{㧭5AʊZ$IFQTjf|ê%WIWJ`aK 8.r[DmY7hם(?B@W](ɒ')I;o۩nGR}cw /𥳐lq㦰҂8Z.wK=r,NHȶz*vpw#{Sz(€?dٜ\ w§^q~lz3y<.Kꆆi>u歒7V/݊a昦A4;N7ڹA?MsB$IbF\[/H xgE_2,wsC$ -2u\`{/R_74.p#sNcFIˎV$tgB $"ޙۈ!V6 Pb5KJ:N87oe\l=U3w|_g9rt5,+󷏓L8zr/7bLň'h=SjNE,r;{όor0PSgyg}W_}H$BpUrZnn¤ˮ:Ny֮؎DJOLEIҳ,V&vFHqnFn%Kp}U]kyWеꡥz~l߾￟'^v8 o=as"g yJX,koTD*F"xǾ WDU'<ڧJYi,8ao:qc1g8u/^fG$~:}o^xa9qҗf7.&=VKn_~idIfP4~.Y EMdZ9~WɆ;S$eZ#&P)R穧bV"$Ic'455qaE!Jo__cX`A^mNn^RL!: 'ٲ6 Sߞ+ݸ'C0j=^EV-i3uÑIMl`dbo ,@ |+_aϞ=MW׫$L1/ECCu-W2rNw18ͦo04gG"*Ґ9MKK0@Y!Iɔv|"s&#P+C Ʊ5tt)s Kp pJcc#/ُwCeVikk\{ٰ͛a*}VPw3t}/w[{x񦡡!x"Ip?wW@vhF]QʪU(fh8g,[ gEI6ַ"Pe$LRJ;_67g}p%Hvd,gj{UQ- aOcxɉ̅qňEf$I̞q~:0pcK3moN^v' t&{m!(Go'GՁH3RHDme3BN2u^;lB7N8l}z![L$|ഝ\x{Ï~#>0w\~U=vbk$ڏ+P4д]8 &8~ F46bPZ6{ާyqO&tseB5!(G 2O,I8Q S wɝ{CVyؗSjh´-WѲu4dJߠgLB)&_Wc91lY"VYqTՋ$YVEo$OS?!+w IDAT9e=o4k%q{19Ꮳedms6WZq9Z GD$I[#O8WHF\[}lgQ_= իu{Ȩ=z$@ʨ ,YG$ Cwy/H/t0qGN6ΙoO F{kpACl{.k[,3o֙N=CUuֱGyON,c=*عz̅Q0ULuhݥ pGG2ɫ'&yΛw1m\\[P\YvTBpFkk+ւ ?04>[,w1Χ:ji1੄#A4_ԑx?A%X`]"d I2] m޲e dXɄ#u@CV ?x%qﱷ|#7yϻ$鮣%)1az\Ua|xGT,1Hb Muec:Y{ed/(OSleaƿ+Nn;%,Rw'HIϥ%7Ieud"*^!z¹xF+t1x;-^wͷ7OFy v40.or&Xlݻa:]/׬Y 2{Hj1# F>JT[,Faۅ0Q{l2ʢK@Mw8U7c4lrKLزe ?c%CߜP,pc>oCw ҩ YqP me8pe8p V/}齬YMhjE):Ԏ׫LՉ'k˻ݗZٰmp*c$ @ճ ^,_hnWj{AQqf/пLm]]Ct/\Gho/ί:@Yݻ~KF`ťED*`5uU3K.TF)֙h=֮c }9>X lv;9u*_T2~;֋ŋm&VZ5OY|A}__XaW[j?j[r馛F S ѯtvbv[A,STuoozs^g>9X[(P-j*)6|qW{ws "fo_mw6o,nv~6,É4!L(P-B ֈpv>Ǣ=vúuhnn?5Xv55AN(r$&/=;O<:HH$B,#wkkz-N9`%to ,ڵsFwXrشQ߻}v|%k߭Z|!QS;d ;W /pnڴ}~Bܗ_~}*DeE SEv7x7N.;`"*s ^hkkW_6Z[[\g-%Wlswuט\RlܸQcoAxƾ\ U;g*g[+ñ|r(`0H 4MG3gx|ǰ5<3Ÿ ߕuxT02sq3:l~)CUUN)y:Ohoo.70i'cϟʮ/ z8 E:Tv)D׻qܪZ1up.w\zSxgM?N:E53T1yٔGwQI;e-MV?r&<*a]e-D18 \{ʸG 04dИ=~dI$sJav1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4z UUUUWUUUUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUWꪪ$P  BUJAJ PPUI/B P PU_jP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_*T(*U/֡j֪jP֪֤ԟRkTkRjAA B jO֡kRBZZZB֚ԃ/I$H$H$D"D"DI$ $$H"D"DH"$D"DH"$DW#ꪪLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???$??-FpF`dF@?\?\?\??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6!%PNG  IHDRc IDATxyU￧}2I!!%D0l WUW/ Q$.UvȦ#B '{2kUǩ{,|*]յ}s,@B-v{;w Ql)h cHeX’!y$H,iXj9q%i`qL@j'[C(y 0cfÌ 1u-KP0Ɔ됁m 2n˃Kwi.4MòL8(Wvy5B\!BS4 ]sv{ф #p8hU ]w y@^l!  *$WxbP!!u.͍-sG+(<颢!n@A%5k^lJb PLtvu몛p=>n_:pp@OBน-R0yRuGQИ:bT8Lw$3"!.UlJXxhۿ3t ^ ҡCSfX\>(sbw ߡ;n$nĈQsӺOeL!v& 59{l<lp(b!Etug glD<%f]ӏ8amGCQ8L!ŕͧiʽ*)GN"0y@$"#-^?":gjH,! w;9B;%͑8LaкDb!"Bh5/ׁN8)-,)BJw>~Ph7X~_Uc =?8$('aF:6,[b>-(kQWHM(| {mOOM##= G H6l}20-K4I'!/S`O{+_h9d,ȣsЄkՇ82lޱ-;?B381_"Hh7H{Y)gzX@ɓq1$Kaw‘.B.$ʲ^e <5c?iYfKZtt拾{/m^u?rZχ8k GGXxRJB^t'سukz( TQ%1C# p}Zl!385{Oo)45LA"h\E*(&7ϥgHvo)HEAtſ7̽p;CG[w G{38Ty*&c…##2=}C[IHiuRWWyy:#qB u pM7d8ǩz.|>X*tzowh?m{K׾5.2@x6\x!/W y]jL:?5lo=0J ៛NuXgo?O\yg4@H.Bǁt",W}$ dD>yx\^R/D"o(`j{`EvIPS~Hs.}A w7,Mo*I32FSZa"ޓ/דӧO;T+W])+niN=躖!Mwc&2?'ھ}F9~938W!j d46LF:=mtvמvC GAUyeu?Η/k|0~5UxͪU8?oWҔzɣi8HXRfC w T(ԤD/~|tnc#G|,+WvWZŃ>/~\J 1"}E:G;BPnqvݐXc|}nuO:Xj<c"Rn~_0v0vڛG`, T̩S'++˓vʟ'xٲzطի% W\9tK/YNW_} 7fzڳMh5%nD7G*5 LplٳaD}Q^z%~ӟUW7{A4/P]=tʞUporR V/"_sxN1y|m3BhLw4]80j(5piZc$P{)-*=';;$%6vmD ];C$is MuA wguV:::ҺC B޾tpODH$;6*"9E)YBLjNolyW,Yf }IG:] r`\y]pB:&tU H)Wʥ#SayD"6lH$0f?4ޱ7^~n,YBkqlá{7{3LrZE:hlA)@ !Ts=˸kfO!wЕyx;;(:]uU,[, [7+4/RfBFCz8Vfg'&K&CNBnN4ik!4f{9l2.2~F p2W$#}VfIV{Owhu[Iz b ,Z(_ SO˹wlذ_޲믿q^:Ha.xQt #9Ckk3 ʲ:eh:]mRf_"ϧ61/}is9BU֑H #Edgŋc KH$*YU]|9m\$sӞ=%/J!u]vBYq(IOB`ѢE<aGs@7_^~{uz6',-j4tYttKEe`(eu^65L pByu iyФ~oPzܾA1$""|`Vv%KD0 ƎK0$>l|Ɍ?e`h3Ϩsx2fL]]=l޼;|;~_ˋ>y8 ̙8[ׯ:;;3yC_l]Gbd{0 NpfwN @sSF_L.qƜk6t /WT^wͺu*ܙgIkk+k׮M`6A~b(\{cZ ۋЅ ]Ky4*zb}|9 '5KiRr OZ WsDr.ges-ym̙C &1M_r38V>.h.Jֿ( Tqb%w Ltg^tEnwߍ8$ciGeYvOgkBO!N2ƍGSSiOGBUy>Oۋe9{~s[jl?=TBheYb92\9 4͕to@Dҏ㤛ıw!XDJI-9|/U NĮ"E,I@;WDP(=B-J=<|ZFMhULaƉCy#݇yl]-Rl)z;}T>ƆY=SO-xڪ]^dI(]vP^)M(LDZ&4^0'i熺FܺI R 3w,4,O,DӲ{ ]Wz !doPc6mTГlpWxݏ`Ym4;Է6Ed?aoib1BѮ'(ɞ;w;-]\vq.7IgQhI5GJ.nW/N>dFҥK&%-X\oꫯN뾛nv$CFi@t4G'6tQE\ _UƊ`'&|;[o[oU~[r_y)!OSa3íIl麼#n喢Wrt]l=].YDu]_xnogyͨ rܨiԔ;¼pJ+Χr _~9uK `-^Oۇ&4\zx^Ͻ泐oǐL+EH)Y?Bugkz٠dtAk ?|Zi_qص?yU*F̺{YSĉD{x,Tެw@‪Y5Ph,ĜiH ;ss=Pv7c*#~k^Cc;XXh7x_22PYԴ}$p@>h 'nFնy$@{E{G#=TaWXhȨe /-[DTSC,PK8C= VMh\./7Kw#44†LjpBNoo2PN yrvPL@<o:_}{iwu"|wY_+FݸtAJɆmç 9zBL˴om椓R*ЫW : ҂w<=w\.]ʷJuBOMDJ!phB/ž@N:@$IY_5tMWO5󌶷RfJ\yVk֬ᮻJˡ,u{xXp T+wd䠘Sx]s9_ ( TW/sFʒk.4)l}kPըh/󒏒D5%/mgP KZ蚉Kwknٻ[QekG4Q5=z~|jβ.;zq_̃ڥHh7p#7"XEmXj+\$dDǠi:k.`+əCY=3SH%M"N!4Fq]lBFфF6MWr2oZi<_:4tM-_Ko?ܫ1,C%41C l3ЄR~r4]3g]v{@4d&IE" aɣ%joʅ]w$zÌ'7[I0ibZ ,1uۘ7L[V.k^XU;ts0 >[ZRpneҩS*N>s8fBl8F Èb1C=,JYuGJB'u["yǰO}#1H${  b]IDAT~'35TW6y8i`X&ibJE<|f.r $ ݱjo۝^BfL% iI^P-Ca VIA '5vޜ7^2K`ލg 7~dʺdr<, ̬r5l^3 U;A}2 z*RZ<9|vy42)P~l FՌɤqGcYvE s.by+)z^R(M% #;>ʩL "̞),̿cp}xlH)G+]f>xZY{m-OlCM&64 L*%1I}{`YϬ^'R"O^? 3Uj\L3'[, #@h=&Ox<ׅQ!o$҇e< .Mt$r QW$1GO8MC$): ^hr1+e;w[$Uq.h\Z2 V_-íB+)tbwfZYH`w1\7,T!FΑBɤ+c4Ԍ`J!Jy`wf;NPN*HHh=9)yt!JZ$p{*WY3F8TC:*lM cgU„lg Rb!}Լc!.K );_4S$'AzgVuZ&HFURꪚzuޓ\*R .HœuG`q@ǔ&:w[^IJs-7bv,ԌX'TuX4j*Bܒ&:w[aD (vzw40vݸtxx<ƺַ *`15L!jך J!:QtyP t|}IENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT )4y ꪯUUWUUUUU_UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$L  BTA֪Z?/ATkRj PB/꺨BBjAUSZkRI ֡֡_֡kk_ ZZP֩?֡JjMjAW_*R(*U P _ZjZBPT'֪Pj֡_Z/ZUBjAԃZjMj jOB֨( ֡_֡I-jA_TPPZZZI"D"D"D"DH"$H $$"D$H$H$D"DH$D"(WWfW #ILtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???yldy$??x)FN&!9@?`·?`·?`·??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 7PNG  IHDRcHIDATxyt\՝?}_l˒mym&6 K@d v7 0 IМ a9Iw4llMe[Y[jޝ?^UJRUR-9O}W}{.OI $_I2I$ xLR7zjkkjy+R˛5{=hZ£f100˥-JB5` 5oN>p7קnwD"eg7mJ8|Tc,l T$.XwgRwډͽu:qFFFjw$x~5Gة;'ox Ve.HH䥗^RwZU@nH0! L&OBg:q]v ;v'[@6 `_3My8phC <㤦"I~t6nĉKt}[/j4 \<jW?΅'ra V܉ن^c:뗐_cvwĵx_>7O@3)4ld Kgr2yPĵx>=˰w  wN-[2,˸\ US8G⾵pgW8< N,5k*w߸Azz g>i|"O9 ^⍸<~i{Y*,8 n? (R^<Ao\# V__/~߉ݻw~_bŊcmq_ly8vZO?|pa AZZtsabukۺuxڵk+1]w_0?̙3;w>U {%~_^i$L5\Ùǰ](X CkS}Yv-W]uiii߼NJ QZҢE^z 'pšC"w/<,_W^y<%%%<4|xKz6P=lZ} .{H8!eٺ$ }= .pixje-ŘF~xPDjǞ|I>s~{..v גKq$QV\Ɇ7slD$a-穧B}׃/_?cT˪6P[Fyq eT/e`pe>IXr-Z|~rA@\DTUPQRTU> ;,##s!2''<@4ںj!55L-\\ iy֭[GUU{ T,eQ2V/߀₧ÚFۨ*8⑸Oa08qℿ|ɘAGWw;zکZt~>(RۦMĢEđ#G ޽{#޶M_e/^m~Ũ<'O!IKKXza{:tEXCrYfMf)fNi64nN.\qN: )444_Çs)~j~*F\s_`F;˸AOqqɜeⲩ>O<?o><˿wm&q`020؇VGiIb+.yWXjMMM\4 :QÕ@o2Z̡`0'/7?l Ql׿*ߕÇÖ3-(-bL?BQ~] ayE~WR__ϝwމn{&10H7_{n ␄zÈGHaA9iY&vctCQ\-c,c̣,,gϞ&Vt~vٳ'x/^:զZY큭iK^v1NÂ4X/CcZfmL!7bG{9y?x sg͸\.?=n:Y`V'|2².۷E.某{nz|l 6>ڹ=1?om"!M)i,(] st$O8ZضmAoq8]4r4ك.n_f7cvpԿ OwϪv̈́jO͛X,裏WVӡgk}}== /Ɵ0)-eXOq~eϷ%Mq̘\|o/rAKj!’"N4pذ; Վ;fP9x2Ѽ%ʹ+H{qR(*8նLq5j߅w׈%2Sk[F^}/*HF5Ahj̈́lBB]i^iܘM*j[ 2$dẀڌ8]vv/7ћ3ģLP`$%̀aj*)ew r8#qS˱SNTby&W@K]E{ӎ+FSR,k%IE<ǑO6ɦ#}*MDMWt5w-8%넻rl J!u֮4w4Bzu7=!rW%OT-V(.;B(o"fjq>0OfɢV>49P!tP.r|;Mi.,v<e;nÚUu=1E#Tqm/jsci|{ك|+J)(K} ,ymbU8]yUK!.v4Q[|@ 'H{{[ Z.piT>ξs^3.Ł.^}kdsq?p!l<[N$ݬۈF'pӿpZ}?ykY>fyK?O0?zYQ5YާSIODv t~>Q踖J+z],]R˘~ֶs_:O[*nǾ4ɻvS{%&$2'+y&ղ# YH;ÿ\)`[6nj ctt6}>]7W#<g{XibJAQ\WH1=586@Mlٸ膴46qJ>o5gl|\uiYIY\K=T!IH~HY(Ԡ(.NB I8B~N yA|Qogff2n&ZlZ} u_"?ݠ.^:ͰyzQq2x$#KU+B ȒHHnZmy}ÊnAh ̻fNˎi'+#۶yݝl^Ee zzi>KSщY$LJNJ\(I݂ : G5?"JHz_'xU.&P\0Uhlp7V\OnvGt6r:+V (+R?^9iz]B"?>mz*ّ'`4'<<0ykcwXq)NR\Nd Ƈ-w9myLf0 gqKzף7 g;!=-LA:r퓀?W&ynoZ)GL٣R Hqǯ2<Nmp4Ȓ@Q+OG}?,k0G1Y TxQok# O+u,ɢWgzw)rw2a0^ӥ!@!`0rt\;wifa01ZFhVx@Ș{H$ f4*I\ E!ErW$SZW~JFZa42X7=-\t2xcB<&˘"CiF|1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4w UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$I  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B*(*AR*T ZZP֩?֡jMjAW_i֩Z5B/UWTԟjZ?PZUT B/֡j֪jP֪֤ԟRkTkRjAA B jO֡kRBZZZB֚ԃ/I$H$H$D"D"DI$ $$H"D"DH"$D"DH"$D#WWf#Ltbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???$??'QM+GC \A@? kK? kK? kK??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 8#)PNG  IHDRc IDATxy|\};vɖWllGS $АЖ$-IKx^6 5MI, %%%v MڗzH4Z5s3ߜ; @奕,ba:ʊqpOs?@ylpf 欦NIg(*[dh?%ěil=A0(oJNϧO(u4Q !tR2)8C D-7'oR\Ɯt:wr4MCUTEAU4I۝T?BOh&5=G0ʞdžԦO ׂ`7HrK/_w R !$x u))ƃƐ:,/E Hճ_|ZAIFOx_<TUc{Ƕ->}֯W/lƶm,$Micܝi$g=|*؎XX/:tl Ƕqri,YU8R:$}ْHř!8q#?GqA9=ݬ;l ! B U{Mo}/Y&8]fҢn{KeXiXIC >tYwhZitmRSy1-}RpF.3Hs;>ͦ{3#mfO[uim @ +K:LKxC .“^:_eزข-Xǘi MgiA&zyOݧSx$|Gڮ#mȪ3۶GxOʈhtΤz8 .<.X~g+r2tm31(B dpLjHFGhV-ڂGUlѲ-l䭃ϏFL)剮g&]1,P|Z}aƈ%+R*SpɼAz³nokPH+1fW^N0BHI8Tx  `dߑFpCfH>_,\ ܩq-)c`ehMӰ,XYzIV:DǞIo'f,].s@ބ,;߯rfa&Aޱׇ(>3H)yv ʻ-;ᵷZFpҏGµbͷ,HThD-?oh#'ܼ+2i!v}gM~CDg"H)u%穗qPv3"% < B(?q_l>u>5Rfrs7PUΆÅ<=ucڔs\`;&`m25p.FpEȧsnIWM fVo'RJK(#2)B,M=[b/ lt2w2PpHHE&(*t=g_, </od0\3Y'm/S;5MKO> g^*a9ӗP9})RJLK'lj';&(oess"^{]yd'QZXߗj Kcgw֯7}&<>n&e/ħk>~tǪU{iMq ̜uGXaFꆱױrΞ='3vٻ+mv)5%9} Fp:><zql|McTey8Gb}#8<_*"n&,+6=}ti:=,!oAWﲬN86k׮km۶ >(+ef'GI Z#t>p}?={wb8vzb,$PcKo瞏a\Ҭ 7k.vr>f-ZED 0X)%DsDCR8\ԍe 8kfU?4_~9`dó>_ʕ+Q'xbHc qXCJh}-8Df4e ,K͟穗~g#KodLK'h '{$`Pî~+ٷo?3 s;iMIxG҈af&__MKOq}}  A"Y:_җx'r'8㸉mۢh:ESsx$c;VG1cYGXD9M{H=˶ xpkݚQrfcXe(BY 伿Ov}t#Iʈc)+gBDʹב2p|l e޸;zʈ2☶a$1-۱τH"fpX9d*iXWm<9P/8xDFhh>N2{xic$SѬ;u080ut#a؎5hf&r= e׶68>i$2c$RQp>VFjĚ>ؿaӟ4n0Sf4SUq4GYьaX@2,@r5w2*J+)+I?ӭU@@J#%9Ζ@^)3()F9xe:-˹ۆVol>gPtgS%y,NKbtxk6P\XNȟG~ǔ!sHqCKL5$?\L2VU_z)Xr~?ޟvf6 =X((^F_䅊I&O;A4E#z˘V6) <܏2-ڈOg[O^ҢM# {W|o`!BUT|Z@QH5ީ}hXK@ʵi,_0=X#QS. ',?wcܕVT5#8ʭ-Fi}0SFR^:g:sVoxXXOm >mYKG:&TJs{-kߥv?-Iqw~5(}x2$&P̺d >th5uqYF4OʈsU>2ʊfP\P3C~|6?P믿[r뭷2|V\Q_,}Ѭ_[RXA( 39L~_MP̰|fTEôuڣM?ynJ()p??~{w}Xo@ng.rD"466RWWǎI.p>[.e>{oVmΜZLL#i7xQ:4] #EpOKݘ%+EI4W<s6ȞYZ_۸+yg?p=-ET;Yr,L+5qU2b;6BJ/\G^EQэOl1Win;C]s >/ɭ}v\KuO%"8Up|p'S<ݯfyU&fBs&1$e`{Nay(FRփt6kv$Sq>CZO~$8r3w}|=qgU,BRuZ&h !M0wRB!H$#F$5RO0u +"+nfɼ CH^#~K{qӹ\wujʜiffH^;zf}"+\q:'i6 qtvJfﬕj#^8k.(xR9}i_7jgY^ +@i5v۱(;d=H4$iDt7<,AHF묶9U\I?NԽǁc;hZKJr/ N[f~Ff෥;uv*8EʈY!q"!6DH 3I,N,іَa0_UՆlArJ*PUOO=%2A_+''̾pQT3Ҽ<:֓z9&h#h]ԍĭhEt9@T(H[`>A:9ٻO3_ϿHd!6&i9"-pp[[uzMTEES|(?uUOy(Fd9ùcIR/ fII ?4VCA6/lЮ7hjjb3w@xG9t|gɲML@JM I$#$N/FŽZ 3ύ`J¼27Yg(/2+ٿi GtLrͥߛ܌q2`X)(ם;sʆ2j HڛnㆻFJɉ=n'hE6ԒCR O7&/T#mjnc7=o +[K/1o<BqJillZ E4Kvou>bV78:ea&sZ!笭USOqWswg_!,x7u2jiѴmuǸh'Fi>Pp hJ|PSN/J**Qŭ6ʤ̘]Ʀ̱ӧΥi= Oƍٽ{7:po~ V|_z[ㄌCn^neܘlB"ϝ,#La;{cv3=ߠ)>TUjt=\ϟ?ԏeݻ?Ͼ6H\l>+{7/ߛE-Mv6yma&T ݵs"ž-s?Ĕa.\*rKN+؂gfJ,.,7cن[>aUqlFh55e4B$DKǛ9Uӄ(,>炜W&PLV6(m7g?Fpl Y&\8;0FZNL&IbHixz\v)b;$l nnwʙ8eڛ1 UPHx!jmիy衇rXFI׋H$#D$ ۱1ټ擙C.kHDhj;ny!'Fyyy7M0:-7)ctp ql_huʑN[Hq,ݥS.(**i{.})3à^ZS4䦿]vq7m@7XIߑpXVuLqA4dffL( c(*yep ~?FOO(sUrJv< /}şj"欒۶mӳU{~0A_8cNe4伙+)/ vad\u'_($(@U}|㛲zs'? g/~v"bYFi;8NBoV"./ׂ +1x&Ee O9m3E Q:]Zuw|ܦ+(x%t܂Ƒw>'dJɬ&l%rH=d6.<<p2,6h:b߾!(WNگg|y 䶲̝rJSRXm-!iE(hP gu Ǒm*˫6r͐ v0}AT {r)7`C}=%%%=c ?8j=WrLkN[jMDfNU#nȏcZ)$nsg5,'gKϼ%hI:?1q)^c~G|fhD\zgt7N:HǭvlX:I=^y G| % CX0g y"ץ4B)7zuyCE^s?D§vl~귤` ?TϹ^b/#pCהÖ-οblٲeB"*nt Ɋ*@hJcI +z,1oJC!"Tz;sSX͑{hl=ə5P|4=քa5Zn$Hy6'~z)kq/dt}v뮜w+hBaw8'2"e$G*6IDATZ&%]Cˉp% rU|쒞q`۶mu]=)~ rqxtWToz M*[ʑ6@Bmdr.]^#?\_ (ѳ?~+ ﾛݭrx5|aZH0L8"(@U5יKQQ7×D:/ΙKl D+mF"nND s% @U8vCx|{ߣ۷oݑ"ϒy(BEULs!eE))t]l"h%RG4%t')%@K9^|%y8j~͑dزD8TLI 3ŌUmy/ڶɎ!eUh DZ-9 wqǸloW,-OMvK>h5Q?){X*v+ %^UBwIQ};t1X؎e^~aDGSAfÑ6Ŭ;s/RTl"~TqK-9ޑ@sV|`czdϤ;xh|oHhT0O,z,:|!,/=OQ?X|W"oɴ]JlsJIG!n&m63[l vz9HIN5ۦ$8R:䇊l OT{M"эĤe[cnf5XO0,v WD$ifWQZ4?eŨ,ˢ-kBnBlG:H9Ne ՟?wWQTT2vߐc e\"9?t >-1OHx -C垱ؖPU8C,4e& ɶuy0 DZI1zd*BRej<' ((ޡ$S.t9&7\gRh:k>zD*F$Hʈ)N7vY ZgSd粕6p#>@`;&D+dⲦ̦q)&#<*]z)PhCwX'clށ*X"WvtȐN2JB᜙+@eLҏx?9sII1O}ef/r69Y7v2M2rkےR>8Wa.0KLcڹ3qD:#ml8P\BURhk3|Ɖ#0% D$U֖̙֘ݖ8i~Oɝ1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4y UUUUUUU_UUUUUUUUUUUUQUUUUUUUUUUUUUUUUUWꪪ$K  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI R $*AJPUJ_TB֚ԃ֡j֪ jO APԟZ?BZ֡jPkUW _UR jO5 5? [ZZ֡Z'P֡RBB֡kMjAj $$H$D"D"D"DH$D$H"DH"$H"H"$D"DHWf#ꪪLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???yy$??<$LtS"?l?l?l??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 9,PNG  IHDRcIDATxyp՝?o]$[1l6˲08lf6By3@^,R7y"ä2I@2,ƶnٖt^yv%]Iqo>l1]@tB!R(WyeD)%JI W{p @*%A)} τ\# J>i{og]qmB E|eJj`DSwC  F4qQ͑ EW @@JT,W?:/Y<a͹_ d^ru2n& ~eM >+&rj?tn˵`TQ"tQ%B1Y޼HTR?k -Dh*#| u[z4-8ܖcT;_%[ܴ*Z+ nZ F&9&iq /CQJR>O"=y.߿u$Lj:aEee(6n}wgxRJJ޺^bi6$]2шp' ;Yee9ܷ Zi밨 %OlU:*E8exy-eo㞅-c1yܶ&`NIIg@ٕx߄`QoH%9ij90k7 g8B!J9ع 3!h]tyJqvJ1yd{|[ݖ`dr "PvVM, S/!Ny@'d+C6 P>AS}ZN$.L, Ȓ.&Oe`\PRCt '|]lߵ3Yz%d:X#/@hH%lxg t9F`Bk#pJ8^9,k^e$dn)Nw䅯pBڔgWb ,#e%Pe=2THxx~sس\at,.:riw]Y{.dBر)g|闐zDA(MGWػy(¦H(nH<2j> =CL9,j<[ xzFsPz4A:Rb3jX=R}kߖQ);G/2ٵ1-;n&_x Ily&MA>yvk{+#;h7_ 3B?fAK;6l}f4Kq5BVz |0@Ri !v2:ߨWRL]] 8>0 x?{۩9jkk`1Srb-1@pYwܹsTGpQK~ǓL&􅦦V}S0k7r|*Pdjjuy(t0bqx{f0?/P6s[$(SN< le׏CbOb ߳zj$>0K;S{b7=࠭0w\iyڵ FP1,N`. 0;}yF:,d88ĩ-[R[[;džI0_~װLLW~>{L3aZ"ؕ;7x#?Sso>Ϡo`Y6鐰lM v?允?@d= DJo~D9s&H%eB $^}tՃ+ϻ;ԇ0MTPPps&79̿u*q4X`ס/LBvȞ3 )ץ\̻_nߎHil+ h/R)䇒2ڧ$e[X)EI+8"Dd@#{M7N׌B)z'o܆cqA6NH+E<N*YC`кxh.WuEx|}HPo W (ze  m1adϙ ol-5QXJW RN N2w|VY+R(vQE7)zlѠʛ73v!0|̪a8YL1Jpq,p;H&kIEM+pSZ0,y7KqAuC*of|I IZؖ)@nrټqo<8|+uZ0+4#TmxeT [qҎ+g&O#_ WPRp(zc K9!t(I9ؖAgާ7Ýe v䡇ź{a1oCDSyI5B1c Bd;;);Ow }IB=C=W;X{|ILӤP(޽{ٳg/~W7lj8Y -= ֬Jʩ!4kIA._ nMk8栅RJT׿έiooguVv܉̙3/k&7by.?6{rjo ѩn]:(a GhA444SO~zYre뭭!؛rv2kB?O#9~oH'kq4~,1:Yѕ;H.!.>i{oD, {ｬZ Y|y:10 ζm^gTbF*9t?4~H7MA6w|M42fj&Fi"dW,ẜmphW`>lF/\ot2z*D|2 $ BgEax] (Xvx6{d۳tvSVi~f! n;؉$ !ԠP%W+_Ar.6Uگ9=Mz c3ѭ|?. ?BU@Obg6t aDp K6I6h* _Ց 򻠽׈:ѭ|7wC*޿5o Kٴimmm]d76pT]{MMMR__A{wPWW ,qHD'ND q,ӦcR^FT^`saҥ=w?460{<7>EXl |{s4M<#I{{;r9>ZZZ}We+ ߋ~Qm7PXAŬLS__e~>P,k^/?Yl6ˆ 8p^_5k*?=Y۪p'qO6:˚}GqqǑJ饦W&C[@30U8L6 01 \~m6f͚#<[o g @ػ9>iW_}niB Tx4?~~.!L y_-nʅ^Ƚ;Tx0lzm3Ym?4_{nԫz, zW} ˲ظq#G1%C1ã:S17/ G;˾?vjKNTNҢz4@\R)'p)9AOꞔ ehGƟߌp a9Kqw@oLNhid$aOKcW6@;׍Yʉ ^c&M = f žC; ?b܄9,I;M´a.;m!D}H!ٺc|:Ŗ8NwYcSRUt)EЉ0 i3FX1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT(4u UUU_UUUUUUUUUUUUQUUUUUUUUUUUUUUUUUW$H  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP > * / /?ZH? jjj ZkRPI$H"DH"$H$H$D"@$$$H"D"D"DDH"$"DOWf#Ltbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???} }$??@L%@5^1~?@ԧ?@ԧ?@ԧ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 10 PNG  IHDRcIDATxy|Tǿw5 % "RqATlUT|qmoK*ԢVV_~ں+. (KXa !w{@H ,;o9μ#^wԇD&O5U;=tx]zj6ՉÖB+Abt/ -b2tr KfP]G.bI\lVi}N#ՙݖE"@3AO= Mt0< 4{kK}>l +ό8쩸Rґ$ +(<3\K׏8\3"I>7>$HȨi5UX-vzT5QDDDQDQ/&w- {_Wɮ fo}y$I0t$A?(+λ[vDnb ir׆}mY8r2 $ V$-pJ ˱VTTV' IQMv;6i^d֗i*tӐE dˮa_?(%ð6|Mլ$vIs(%H(hz׋p)SJZJ6N{*uM8stjw7$_!:30 oKmIg`=4jc肐m]k⒏߄UzZdm%)nuxzpDOj 9qr6vz<}{*ҵx y:=9tQ$;=/7 0;F UYEj,YbFNfa%ߑ8{_S"@@ߴ㛘啕 =$ο~c?xcf[w9!㴧-q7o7zEIa9 cdmYW`vP GcpHs•< z9w >sN<" "i 10{bţwJA Cߟ)6EJ< ٷ6ō?R3xN`gpB8d$F|w\dӇ]ؠ ?F `TtZȖ#Y-+9v09a7Iju7|#qQXsxW2r^vV#͜R27?ZW[q/FiJc?ވiL0tҝ}>W;.?爂$J|=:m: 3Vi1(jͱD5v98#F?۩ocȒIܻLOW_]nےg@h6FC$R89HK'/}TvOa}wH$7W;8Ӵ+q)Ñ% Xᴐfb껏E-ݩg݊ T\hFF~<]?ϠȒA[{ 9Y9}wlEQI ``{V-4S M(0_ZqXtctYZTgQFl[p8u }6iLwA%Y|rA$0DsPvc )yWc:[Xe{.AߠpaZlX-6bGe6X%;πSr6{ #RMu'QzF]MnVVX-f Ky x­~{P[6VQ(NyDuy嗀9RO #KW/;l*}sfu"AOnv1نʉp8$ Z㑆9cHM̜?xػ= Imd#2E#K|$<cyu'9st-86Kܖq$fM j>4 HahdvvB$dYF-),ogI I2dAQhAmnDQ&%ˑiƸ1tSrV$Q&ćR?݆QKSq7"jg.KKX-cesF 2oLiH$0"a_</к/ݖǦxGhJ#Q/ UfJr 3,x.~ C;tw-6τW`F84Gp$:+L3}dTMp}4C *~߰kߑahF_]kUcB5ߜd& Ϲjjk} K 0P@h@7̉,2¢n^DJ+w wUfu/M0E C30 >Y~'{:Ň?AUUSPUMWL1*`iFU0g@}Mk,~/P ޅ'; Ϩ[nO= 5nUu B!0({2NG:zhS[:Y. 唴H C3ؼsUkpz6r2 ذcu}ҨeT4{j{\p(//qR;\'@|t]ߔ-MM]-i^s$  hrr8X}Csϙ}`jv4CӕHaMnsam܃a)yUp8:G0aj0 PT?'4G#}ӣBzz:x)oL9(~^Q뭻$|}{w1+.{*lC,(jMSP Ň&ؼ36Rźu|bzz+iii#4:uiyKןNYY~kDl'$#bkX]UU4MW1 E DpZmYdcѝ1e F_M8[B; -ZǴio6Ķ.g!%%klbuʔ/^̊C#MPuG< >rXKׄ˙9ce/uXm3f5*-\ rEOt:0|~a] i)٨Z`s·@G"eN&4$rs3y#6v$\<?$.ZEBBΘqHse^AǁTV9g8| 泽[S9]!o}"^OzGڵԩaɳGH덢q{멮yY,'裏2O9D8#2҃6FwB˥?)o~3\- ÿAxN9np>`#+V5SPPicᴧ 4쩧rziZ/~ѿ؎(X-̛v9h#ijfMkThQ1;$ĝϲ`jwc;dѢE<#qL8Iθ^]kǖ]kXNM1cSA) rWmس36mWvniEYh]D|;l!iᩧ0 s\(=*'A%Ȧ߄%#?eddƑؾ{#[$zwҋ=B<;oˡb ++sb r9}=Gcw1FO-5K~^!ivQmE¬Y+r9TA\]1}t?h̭[IMm wF1Y\}*FBܖƎ3g$?? #!@&9r̞G:(bOju0sYzWpgo0|>l)..Jj.~蓂ރp:[WVJ&LL™3g߶{ G{ }{ őGq8]긝4eƎ˽mǜr!`F tpzxNf_kGUL^IMaKa.^} ʥKg{0}݇륹f67K.u?RFMzgޗ\`?~ ?MMMM-Xs8?7p֭^ࡇ}zh!qoGWGj{ J!#-Bbn(cʔ)̝;_*<9s0o󩬬dɢQo8lx益ꫯy1gzMј -}>]!G44]k]0 zq$ݎ/A={6<na2a~q?UC iO(|W]uwv{Ǻ`8g5* -P'gh e~s8u? v-oe˖1n8Fāo^[WIӞưi"8q"V%KS0Vo [Kͪ X#et4ME34JMWhh]nH~|ǨW_}xCk23>.6I|m6+5j$`(3#+ϿWޝ'K/X`nzuVձSPUej*k0CׄBDs% h Ks/_gR)%)[Jnv\ 7hnn >뱄RK'T^An_#@3*~e:ǔވٽQܷyk(1 9v m</0&oյ;hu?A umU +=uĝ{7slFB)y;f1w_vзv{6>GPvʕHÖ, "ՙA K.ZLŒ%:rz駩 ??O} ;Ë:lBNf!.GO#e~r[vꎰ7=ڊ57bjj ہt,0Ǣ6md)o ~<=ՌO>-8J0`3p)f0~Tif馮՟!hsosk^u.\/lhyq|v' %.vlܾ `G"2R{sG,x6&O7|Ò%Kmc=V8pW[gbs2A7|l4bolo$.G&YEdas!E n'Ō3fW$ W h<#GEñY8HufrfLis![Xd BEѺat]'ih%48sԺnX4Y`8i,VvÅjGX-V,يa(r m,/Ͻٍ.r‹`P|_|EfΜ ӐD)Ђ,hbaM!`Ȳ n.Z N^x;w0 ѹ>ٺu+ϾWDU\V,,viZ}L!)1#ΌS~>,7^gL< /,YJ,YQ FT} ѓ^] 13ÑƿK/u]ֹuQ[KvvvO?H ĮLXMa3qxmI' IA}W_u/,T8fU&*Ar2,BVlxlcʸج,y9Cii)O=ۮ 6z@0Nzqkii @hʐQiRD&L@QD'V-_[d:k鯬 *>AsV"%YāsYg1o޼sфT|?MZܾ4 =Ր1_FoohFMX'YmŐ,[,y~h,yb=܃,̝;7a6 ,{zq.6aK3$܆8m 7N syZx!`cǎEŨ>VH][;^x&Ymu@jx,7%OI1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4y UUU_UUUUU_⪪~?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$H  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡ UTZBR?jOT֡U?BP _ZZ/R*TRkTkRjAA B jO֡kRBZZZB֚ԃ/I$H$H$D"D"DI$ $$H"D"DH"$D"DH"$D(WW Wf#Ltbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???y7/y$??+'= )ॻ0@?Q?Q?Q??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 11RPNG  IHDRcIDATxyt׽?Eb@"vl86qL&v^OI$s^2<&&s'K杗s/;88,lIhW/UtPw>P^n ``>BH!"ѮW5}>@*XEQTEAA{(5דR D`aIJ) L0bi8 衔q#>jG;Ϫ(8x eGJIY:oF8Tʼnύe|g"`>Bh#AtY1v&Y hҕ'+qI3c@Xr B T[Iͧ= RZYf*R"tt)XuO;xXJ_FH)9}@J!I{)hj=ڦib] Vv6}螯 3dʐ *pt^z]Xo%H;vge/!!ǴWM3iƽK?vߗ7 )LPl%_&$V>jxk+,.$RMpɷ3O&iU!Qisjw+ i:RaY~)%R! YU"FA׃I$ULm7bgXWV:zZhjNIg0ZodLvqSc:smÔ:x-dpxzZ`I4RJ\8^<춪w]fڻ0p{ξb9R>n V&4\9t0ٱﷀ[ܷwn5u Q vtȊtLkƐ36kB-T:79t*TE*q#ʅ'ի08[?zyV#0fxW.I,!d=d X_)L9,!#d-󗎳n^J.L@ɪ8.7i[7o7ČX*e5x}%94a2'îv[R!Yl{;޽ Kp~+ #ҹ#F܌e]!zʉ=׶Pt%UT!] kNLgU*{ݴu59}a(3QĪIN$vkZ8ؙz&FSp`'Ud6s #C!]Yn>8[+&bu=K)Q3{>BJTs e2alX X]uY&+lqxD"m/oceyfqҝkMbyƔxNSHĀ#YzgL[RHEun]?mOqASY6ܲɴIhN{JOs?x(ORG8 r쇪)yUsK-q#N<O;3Q챳vB@K%&/;Wr;#aⱋ%sY.2ECgw+ `>]ݭZ÷5c:qळWiRs%IX=1HGUu4M7o0YJŵs;sRyYv)WX<:O k0c&w=Y_hqjikpMAAU[8 =ΝtBOq5UG׃^b>gVsOcٸ̠|p碇: /숤)-퍮/sSoHKR]^]N5{BECUn0G}bmhj̮Xk;w`)QTc0Dq.. JHVەif8XxahHob}L$S7afkhcN]8e(B͌E( ym; aHX¼Hi&UGXJ񞴊b13$3cʭhZUլMQjҌTϮXܯ3{QNP:=ZR\!|R7`Qh,F,#Fbq0utVZ=ЀuRĹ}yI.BG0aGt{:"^yyyͪvǺ#^,x`]7ens_o!yHɅH+D"JA4Uu.~aDI䉷SO'v(ž-ybl/Y\H)4CAs7ֳ̘:#v@6 })z%>fټB`ȸ-K8Hv1'RSTqa)'̳e\$&dTMщ%k7BZIŢxLH~,CI rh`g.f~]IOuY!YtZ;"(ߥi "V#[Aː{L8NmQ&eSUT\Bl3Vk:_cμjcQ7+}|{>j8s̩\xA[&INXɞ#e+۪V9=vc.|ąa|=fR纚d%*aIX$r%wh j*!L+N)LLH  0aƉZLu&ՁV׷@PU>+<d FIGiMŢ J- oIU=p$?&>V7D:G]c|eϱ:8l188Y Tu槍_ma<'vF%VbH4[BoTŕjU #?f0ֿpDbLxN?sTd|7lRSաp'9f´$=N( Q;uD*W8ʒ#1DڃBDBNfÈX?XHeaZɉn:õ伹#6=p䄠 \|h"\"&z^s1jhmH,0}x7hHr'ޚ.gùƨµ>իr~,ŷJx4Mͺy5wYޘŷC(*H sC@$As_z6Z;.,㧻&kgAQVx_(HV>;wR/=l޽-[K/qz~0 )%?9---466[o_֬Y[or!%ķ~z~(g zՌr+T늩sp[X>Kw*/%%&zRwLa:4l(Jd@At5`EPT+m)YFKJw}![l'O&彺: {ihh˗/swBV|;x?/}'|rd/w=*z @ X7'J,y ,/GHad|S&ނ!AoC )"Q\NQd>8)YQ]iT}Y^J}}=۶_+y]k_oo/wGG{%kq#v㦁x鵩5Rqod. ~(*DCӏ e!4UCv ͎¥91xEe7Ж-[hjjѣl߾=ͯktvZJKKY~=7n'MA"Lcc;ǎ5rB%gXeeaE)u\SQi;:/_n=+#nsJ_ ԕw#_ӟ++‰ihhn^~ZxSxp7uaFfeXTh(;ȗf'lEGr 0h2q#J0G@pjqq.]J41PJx'>'zp̃JC H$͙Ԯo6|!~Sn(`>y0 gZ  $ Xd 3g4MAGoj:ג,93mr߫es?Gd\O@S5¡Bt-) O&,|˗s3c (6mM274~ְdI%?|VT5٫g,p/q]JabF \%F裾)%w3 G/l74A= ?cz?=q40'鮙1Z\PB(G^@ h<~iz޸z?}˝w… Y`p8GYڵ񕯼4A%U.$__ |:{$3h_^Gw 0ㄕ|JuΪu>Ïi477i&),,$??p8L8FQ._iwǟ`rK(˗s%J#ذL3]gرc;v:TU%??bƍVbu Mtt5 aDфPWW35qq _YH7Y{i`1۽ZeYHg8xwt5*㊲SoMۄšj M ŋ׮u03+imy:ZHh6:ttvvSO/YJ#@P0Սb1yey;OsL KV2{v9'OuГe5%2MH`42hŒ>3K8}3Go2 x 3 |6Y1Jƕ 7+WVQP$71MISf+A UEn|dj <;ȱ7x=XË́/ό] 3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3x|<3/rɂIENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT(4v U_ꪪUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$I  BUA֡*j֫ZU_ZJ/B+/֡TU5'ԟPjjZjP ? jj֤֤Z֗jZZ/BUAI֡*ZU_UOP(*U/֡j֪jP֪֤ԟRkTkRjAA B jO֡kRBZZZB֚ԃ/I$H$H$D"D"DI$ $$H"D"DH"$D"DH"$DW#Ltbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???|e]|$??C@@T#?^±?^±?^±??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 12jPNG  IHDRc1IDATxyTյSC4 "Ђ" ͌̃H*8$DĘ=^s}$՗|&1{Mg(@$` 2 6Ctw8U3]U}}ԩש^k$mP2hLq @Ћ _&RJV|J[") W.:9 )%R|ye۔J\4/!/eg4ND_yEA*ԑR"71W,MiD?7zM}7SXPL(S_g;[8]U@u Dh XWqWm?A7u( @JSJEcqXkC~|3krIM1 ~#޸%i84'`;㒛(BAS5\vɑRpM%Ϡc0LYhaAy}Nǔ&D*2c=1OETՁەM$=S*s^1&F_oڱM-[*>1}6(,(F*Nm wmy ;}1 yFEEU5<s= ́EۙEOɠ2D@EaKMVvYYYdee=OsϼYVg#8vw"dg䑗Yɤm'! ڎahS**"+\|~^̱0-<HUm롬|mʲAҪ4lE<7x<̪ oEHxxx}>kT&M&C&$P Mu"C7KddӬB">y?gލr|^!= ?GU)I&kIVf-E-OdBy%w8}=:ichW*Qc- ZO]9*]ɧڪDoYMg|ԺE:a`&aUE(AH'\_0MEQoT՜[jvɡۖ|Z9ih7ܔ01 ˈhˣ*nHqTՁhjfXsuyٗRgUM^z"/h<i@3{@cIpT@7t C4x{/YMO˜eM]ۙӑEE ut#H;:p\yyq׿swyO&rI 7?!4;LNL*YDg֥%[]+0'xtwq92T*&=p:͇|FUm5689{=IYa-!;)eL#XZ3̺ރaJCwƥx21*acFݍ@AmtMnVwl~w{̙ Ɔs\-s'knuE3RbJk24:F<J,٦ڢb4ԶA3>KnޯׇNp09ޏy}ּgp:.ۈ oLw;|sng7-<#]G:AZW.a) jjZ"ǚWXPLe1z=2=G^LVx|USG?eԋid<(i&lhEHEakl{-H)9" _e=$;U5t`[t<[}گF~N)i4#E sJ \̄唕oLU9pe[<ѶȴfN†yGUCgь//ֲx|59SgRY};n|&m-~Iˍs֐H\Zdtd>4kf2oX7QBE6?0aϬs{_<Uurf8ETםglZ*5~#m9ˑ2.Gp׆]~YvjUTםM^Ѭ)<#)Yg5;OӜ84-yaGw%1ϱ5jqboʼn4 TZjs-tCG f@7 [Mu-hkE˷ѿ(BCQ؜E3KW?d 8*hfl [P*~6wUb?Zkfkl3XE:PYhX |;-ф@GJ&B)M6\ ϻ,Ew)MLD7z/P"|PPT$i;NgsFNviX ymWeo}I85OP8q*EFV"œ=<><}1)IE9_qhLP"JYαuHi?.xc ۶=͗_SZrY1?u ce<)pj"-Oy>\J܉F}2{}u_3IК]=Y TL4Po}4BCsx4FޜMQ5=VUs6{Bho|]L6ZHA g҈F0UScρ FG .~#0 Y0wacKz%qMQ;ŶzZb+ӈa|o&d>1a5S;fptN)V+Q^#"ÝiZKW6}hk6Xzn3Q̙eMAFcm`OA303(]<2Vd_ӁZOu*BF0:(/ΰg =aM#ֽ|8۾HiAP-q>p ;㷖@T~G4Kh92k4D }&CQd`S cYow4$2/vm#t+0E:pRC҅ՃDXc[uļnVtm+Ǟ^Djo A+(Db9ۮKgq]#+oga;7>e1CnpF Db)BI(J2qN'[F*ai>.A7Be.BDHd*b@o<?<'矟`΃f?{=hm+x70+Pd2LCG7B\Moew [0n`nOEE-gc:۶Y1R[laԨQk6‚b9ٶdL W6ȉFˇ2eN P筢4رsо 'Z<4Mrrr={6L<9ӦM>tJ6I7 -BHj=UHiˇб\uP ?ڻAbtLر8f]O~gϞ疫W^`޼y2`}w1ٝwzʿv!&ȑ͖*' [g eaAz4,6lhvovG?\zuOF>V'ڔC%Qae&l!0HB;cϟSO=ŬY:ZRK/GӧO}k_c̘$4~lf-e O–-׍Ô]h-"]5FN*|PnڴI>sc .ӦM?>o*ocI\-[#eʔ)Zov2*qַmk77|3/淿-ΝԄ 0mub'r `X8\K?z_as[Q `4 ymIs5+V0i$rssYlk׮elhPϙ3s4}Q~2gbZouVP>/,̃ nE,%`VN}mfb)mW^5NgyfΜￏlxxX@]56(0u~GZ'@$]]$xF;U~gFDlc3?nSAVJJe`B:tNf[×^j}hff&Æ cʕر#&yy 7HʷZa x~mV*fds{iϽs_{'f̟ MkOAEq:\۷:[KCtP{0G, osa s7^uuccǤC 5Q1+$iy\~Q?G2VK̝RJLS\]%@GH2B@dBvFs/G,y4ɮ{pTH|O!BQЦ_)Skж ܖ z"=pv[: @K+P9K]>٣*gn;~We\T@J3^wѢlO B^\TE} !iRv,GGiKsE3Hkэ_ @6>ٴieCּ=_˥ˑJ'w q48t,6T*(,(fy& ARU{LWl E}}Co݆VF _z m͝;?yk&7;}.)$/'9H$Z!\z:+6amB0 Bz-0Z1CD߫8{pj.\LOʲ5wt@!Dt zqer?vX~#}I?^~.ka#MqIҡ9QU VBP1_ֽ$mHaA1z[~蘕JT+%#<ˀBzH8G^hJtз{ϴxň_ EASktd)ՊS [lm\hN;/HvF>KvqiGVS!p;3q93Uu0nh)Rʸ2:^rdIYzSg`vZdlzlq*qS_PU{Ü8}ʯʩ%1꺛73td钰s[vb- ;ÙcL05is~Dyn}%#<"peS2x&Hֽ#Z4!Wekqs/܀¯O= `_]< )nW\Lg)b@CNF&f'R\\K4~cu wxh{^o2ݹder5Gq C'z9zrw1P 6~b{eh<2\8ϙU:<`-nW5+\QECS5Lz CLcJIE6:wF?̟o-;v,*NڐZCfջ*JXNb DQ-J8ҚE7CQiѢE,]Ԇx鐬|u\XiNG4tR-Zn )r#ؼyscGP:)c<MQQ XYp"3˗/L$aKii% > .]urzS1$|WkG***1rQt.wK=X-كYץӛ(s@Nἱcv]t)Sƌ:trQݶ®-2/&:݂S5uj%6lX'iDx8p4-_?OCW*閧~#iZCH1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4x UUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$L  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤P PART*Rj ֪jZ_BխU_/֡TH5?֤֨( ֤/mjjZjԟB֤ZI Z5_$$H"$H$H$D"D HI$H"D"D"DH"$DDH"'.WWfWW#BꪪLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???$??+K*?@?@?@??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 13%PNG  IHDRc IDATxyTՙުW5 "("FP:IdIN2kL2NU6u%h (` -v3ܥz|_ֹ眺W9َ$y݁D8܎aꬼOhWGx 0ukZZ}xCqa^'y3qi硪|Ep?wp5|Z Gڹ+_\w3g<"TŃx,[hh>LGY4뼩W2%vG7~/2 SF5U=@)Zih.eZk)( KxL>Nu:k1e%Ch8N0܊"Ł MχlHy3(,E(RB񃴴рE'wW87^K{=՛v_A^inlG#uj!ʊeE[Gp+mhz1M=o9mTL@]1}EhzFʓ'GkyxGo~c cAUUTEŐ:ݓ~j!6dF˸YfM& #[7sovӴ0ofTg^d+V`߾}X(b%%. _A 9R?c@k AT t'礭I ,\***޿)흔͛y'% ƞ@A#Hiw(;ȳ|ܗvyz-V^,kШۚ)N:vF"|m=㴷CK(*3=ȳj/3Sʎ?K{'ylq;o&UUU9n$LJy[NZv.YNYvmnYDT }/Ձk9 gVZˉFhFd2@;lkwD+oX婀dp‡SI-y‡Ae#(E w!@ڹi M+][$\Uܮ_Pį+jwit#GiaZQΞx BFi}HG;}N: ",EȝNؽ{7O<7c%vݖmmm嗿%W1;C띈LF}/Ϲ)M @"hFMtuuґ0i^NҥKijjb0{6ۺf߾}ձ?fq˯ hq_A%nqVTϣgЍ(E34#)<{G /M6 n۩L0HTpz#`ύI%`̰lGfMYGiio iwJy8 ӟXbλwgY30x'<9v9Zv0‘v6o˓'xǩeӦM8p1c0tP.\g_ѣGyǻ#nJk_.ݲv0zߟp,v8= tVNܨQWڸ H@vUɓ)'8&j駟fŊ? &&NTyɓctaݖBou3,c;$ t<9Fg3ēO>g&Fl՘3l]tuGLSDwGF$֭[CiiOX2'%E4)[Z*B \\q᝘2馎%3Q:%?DJ9H4o޼K{gy믏D2#řX}N+ `Wagќx -oP=,9JKKyGlÆ qș[;-,I&E9ϒ _S"Nױu[@s p#sdTU'lٿ~UQɖt,{Łrt#J(NT +(-$DCضM&2]b^H*X()EpV]nʕ] -$ ôtSY2Uт"4}`sZ4bgV|p꫉,?w 2 <Vعt-@ [I(3:y\xe#0hP3Q-̐H$=Lc|+WދG˜alEIu~IWM#ULpAI"];]pY٥ji3n2goQQ2Mc:MuҠlػ7r(68[,_K;)=}3&wI4oO?0eee־X&њ5kڲoE]Rݝ1e_>Qՙ]W=le0_./=DzFk.6CkK†jP(a꘦NK[[$ҶAfw̙3԰ CM ?|Q[ݫr) zٰa(..f3f 6mMhll3CB˘ZPKCeaphL3Jk8_}GPV2l^:|&IছnbL4ɓ'CM okc?z*$>wy .bȑs뭷rQv͛0glڔDRGҢJ 3ϼqgaJKJq8f9u!y.{+O$n౽(BItJ[^&MX`fJ:kM]F{Ǿ, b\s̬}/6㱬*շ'*(esF[rPSnG$$ f졟KtoK8gޓ3"D=2J# StP hH- 8= ı7pѹe-iwHض" !q$MǸv -4`&zn.ܼY39պGI /-1G펻)vdkd4zj;e]M7g};K=}4'CsG!!DҶĒ؛o9XYŜ}.$̄4OIU͖Ʉ =K!E:ZjU{`QǼ J$!ιg,P)8PByɐ?S~rs&y@ۆ Kbv'k2|N;w!cG՟wil8nA'˻b/ΟΤ# %Bo:LI_ Z~ &W\Ao{[ !=܃uƕ-XBdOfHq" SQ-D|W"<1zHn'cGWx<^giy:x饉}:Ν(ARs""idjݶgml7Sŀ ww;W78Nྙ`ݕG0~/\-~z~.p9Ӯ? +.GX<2#NLMbDb~>n_Q:l1zcT n{qsn0ơO>/s'/bޞpu:EaժUL4Ç8vaZ R5tBLZ;3تj,⨶>,G0rxP, 4r8fy9[v'; >ׁ%y ֶgxk&~{GiI{bg[ۯe}Xv-{0 4Ms QĆZ`i؂p#vXm'"0#Ghܘ\8j{cbyIiĈlFf[fu<N)Wי5NiL; a/IϦ9{҂{2z$ցKxtv2n.Y\X΂{l"Aبo:ĕ"p$59'9zbSaN+L}AzõUnQC'$WPW_Pd̎Yr]%ð]9`̡ɚXQ |r8vӤ;b2GO[NTa~a;ipR-MVoz/-6l-*Jṯjv~VR2(B}5gQg'{ i'7Yŭc$@JfS1'+cFJ[g؋`}Vy*Ik{cϙ,úN8ak'ㆠ $ϗ|ahCUI&/5t<(\Ic't%KU<[=zp˙^"gg)l[A`?q.qߥ4pM *nhhHG4b=x I;+"+^g1e]M7C*R`Zm>z,I=Iio+hiϸDt<7VR=PX*BkfGUonhÁR1`8PYѾdw;/dOeL"qgޘ1HwdU@9#{ew'l0cQ-n}pmU)p\NtȎ184le}!NSALcIDATbw%zuϳ\uùič4f,ܴ '`pp/nT8CQo3Um&>$U6aJiF""q%]}FA&Jgř>nfw7ףNc7bi^KɸsDU5[E!\]28Aur4I\v zbP‘+_%ӎ_:[¦m/>Fu>M@74 3{ => r#umq@ @⒄V?8Ɖ3( weo#DK4vHj>șQU/"nHL g83 ݈rm˱8R/aYkq;ĩEQѴw4pcް̙vUV*5$fF (yu~>)&E6,E:gצ#NdnFP|ԔeL;b>}z^n9<`d_i6[.]\i١k,F%ϠQY(h5**ψm\/vLu=qq/!dgYK,tpm:4ƞ|+'(JG%jcPIYQxT+"T7.u޵1e;^-ɭ%@AS[-᪋-5غ Gu}ekrvw6Iw:PU5co;n[nLNE"HK~Qr4rmL:uV?$+B(u"ϗFOb%^+@i s;ysu+u!d3MN˯-K/ZahFT x-[ξ)zUŋN]WAUԴ̝ W]?x=W@o!>_ N΀=\6 Ҙ_[N+nCρ9IENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4x UUUUW**ꪪ$L  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_T*R Z(*UKBZZZB֚ԃ/I$H$H$D"D"DI$ $$H"D"DH"$D"DH"$D#W Wf#?Ltbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???`X$??C`PC?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 14_7PNG  IHDRc IDATxw`[?ޫı,@$$% ղJ-@񶴥tڷRFB PJ  =m'=dKW˶dˉC –|9Js3X:z)ia阆N2C~vx4l<4*j``ŸÐ26K!`סIy<8{H$ AگϚi'{"((*fʪ EQPMu<]^= 6P{VT8<3l&iLz[v@tQ gvg@TՅJRHi%5A5P3K !PPPP@M}UT֖PQ}!(8\F5**o 3RinL(%[h 6l4uL,hm_H),OnE)a_3Ibs.9VSL}SeR/+v$6?$Xhܶ́Fr.j2eHib:k0uZ xe2ݼ%;o Dy^f( *>C1cf"T!B$|eI$&B-etH$G+n<4O4re`XeO]q4ѽɄ/QUDX'w ȶKP{KH B'vpwgzm~69b"-TVZuU8G1bTlAZ, `A{e_` ꢡ\J}$x->r2 "𒇣dM8p' _o9TS5$ޤ[<\./  %goB=OzQ,)PmRZLKZ :VTW_X֭rJwgYR5 I,waOf*}Lϵ AHiaI 2hDǕKo ҅H_[0eyܚ'kϞv .Ս%M @7C4SV\0KsK#BPR"`ӎW'YP ldGm]%Mg9ĊꃼľKϗϗF/N("h!m~;r3DQTfBz `G>Nɽ$-kJwa:YnO&Ps%_J˲%B!N'~a@ Wkn n*略&=`O ,RZh + GFZ.93=6ȁm)ވ` & |̤)gM:JdJ.Zx+iioTU>%GXK]c MU7Uxqs^nFx+h4я/ْ{HJx|V#HBR. a}OfϿ Ӵ'BUCۦ™_(TUXU)zjʩ;ž;F>TT8E(Yu pr?PP4?s<d \4N='ﰧ3FKwm7r4}9Fޔk<!})q\ҲPr8k<.oď.rYg,eƤQ@EhfΑ:CoGB#45ؾ(i![;ֶLQjhjh˅tæ1l5vdP(}`lwڎVc I;Q5g z50NLdؠӠ ng|+UQcM͵Oѐ"Dz$zHGC躎Ģ`,#xAc/qF n_I;)8v?"<7ʖe99|Q EPM\qhNѐ s9(cC> s3f [yYBv>4r@{5dZdODRS, bʤd?JM}Y7Y>4 e^~'e' %H ^~6-._2ok@m]Y`l(UJw%WRJ~W]%[)*Bht(< h-NĮa{% pp˱X[L*vp8WJ$F7͝%!=@UѸW>)ityƙe p .CvFUuGbg(=f=t <h40~,F|L@ϷIzhFE!ǎЕކ7ZQҼY4ڴ?{%\\?~vrt)M$j0m[c*.IVz_}\sqin S81"8F : 4g yMj+L I$pPx3,S q6aK9.FSK/lҼ|q4w4Ov3`R?Hr`YfE IIn[۠SqGk5,J]1E%ݗMfZ2rxy'k'{@;zo$g)#YX|7y21ދwCCrF^Sj OQrFN'}G,ڽ7Ի" [EqN,K /fر14)s+ TT15{Di2 !Mu wx"*˲G(R%f ⡇";;;|dT\Eh] 4L>SL ~zfc:kZ4 6Wd,箪Z$Ymƫr47.Ս(l4qhF0UKy,dyγ0g`X:N}4oKlh3uWSS~jTä{Yq5=Q'=FŽ,쟲Oy]CyqZQƄ9]~Í7ȣ>󚦺PdU;ot_xdxɪI]Kf_D:lrUqZw}7;vt>Bi)1~ݺK]SCx pE牆TsávYG˫"ɦP-n2ի[+x'پ-E? Rn}Kc/J7̴>\wBGw&t\< 6eY( O&7 8Q/Zx5n`…L099-8' MqqyI.v?5;H;Pa:^;{xۻ˗p饗rwn M-&$ۅ'LH`Ѭ1q9*뎰t-8Ʉ1aIųnsݧ1(= ];h<|QϹZA? 4WЁ">BәcJ+B" ;3|ͺ:BòdN6 '~Bw?Æ K̞s9!ZZ~|/zld-;he1چ 2r[U"A 8X6P(SXr%a?1&'Hꛪف@QU q2:’Z$m=̟~ f^yOhlԊ_~ϗP]-W_M7ݔFfԊz-A?epͅ=, "yOu։.E~g6qh è>ݻnW_}5+V`q~vy4n]9?` Yy2ztDlp6G2% iƆGm?c Ղzڶgu̸Շbشiap7s}oG㢋.+8+܊CSmzE3͗э =L  '3oZ?(h@J_r?aYlePHr H@: +ɒu-8Q;(;a!FLDC=86^%ε&L<dՀCT.VvV)rg՟~dr.E*+h`3pN~DmC~deF/ ܙ‚1amfD1BvvHmCyyiQ({%>vk֬`eU:]9{UN>ՍeX0m\۷7|Wqs)fI<L{Iɮ:\Ͽ bIA/!;&ޑ(JKKҗu͋Ι.DAmc9.% >] GXM1M-<fJPPN0Ԃ$׸p'v%i %N5Tcǎ]2q6Q J_J*PY[JM}0[} Bz RzdA<GY^y_ :CNFH NO`I_2gJp}|p6wKTTXm v}k ̈́ WDsT:4;J#$_AL TKŔm/cxFˇŭz&*ᩪ-󾛲5zO75ewZBQ&iϺ1Fh߹/A,' ^UTf_Gcݺu\uU,Z3gr8uv Gp\^6~\D{臘ʺRFHB u{Ȧ={#k}4Eh=o}cۙ4i˖-fns9|z{7|6+(ߓ@ DzL4"ٚb׮d%A?ir<9ngY&7 KZdt16*)-2oK_Gyo}[Օ7;)Ovf.5'GS"MKQU-eP^up忎pW!b'KdC$jaҼ](y^?s6W,GS/g>_5'z%rTy3HΜt>?ohO=vȳ#Ιqyܶg_ vx 8f꺿bIeYN-@F7H-[Əc~,U2peIy}AmI<ǿ0c9 4p찙q&BQ#D g&7z[`of?pƛ>}: .D5?L(e`9.20 jRZK|r~_1fJxs^vaɜ蓛GYy ;tғPLRJ4Mc̨1w.ďeg""Y B@p0i^;K2^~xG<0hCz-*ia4tt#n_nH:kW9>(;榬SgPTɂqݬߴ&!g2;"UEК!)Iw굇_iWcIL䮻[ ::xR`Naĥ3h!xoKO'28 2vl;>0D Ko|ulM}g1q#`9/Ȟ};R.8'/'\.pkgE ,[ L&i,ҼYu]{IDpN+4a! 0%4-D+| /lW$tE n%##怟N( ęٷ{RwiW]WƱRYe`ô 3a<x<<#_G (A1 fA?P [z//;8v}r#Aٱý\odԹ5԰{v6|3e>;}/'2f،aeG1afqqm P=<3ۗ[neU(3@O 0q(UlI}f MT[ߊYqrq`WB;y?uVTeS 8)C*IDAT}'ͱÌ2f#y.-D9y>ZC!4(.U ?wEfwu&7R09ʫ̘wr[f}h͛ԗ'Tz'zP4x2r H>؞|\9,y{_zƏ8 0x6Եј3g7())a߾}ر:y0kr&>Lq^]H}haI $>Z~M%C;lΦ'y{hE]ԥyH9&: /M:lD>ڶAM}Yy`/}aH z6<2kƍ]ljQp޻ pWQUK>s΄>\s5矅>y9+ނiʟ_Lހ<裬_q pչ@rA)~=׉bH̚Q1FoibdVyFB,]Eq.m[EvF?d'/gPgټ6sx(*WO[oeԩu]lذwߵCDU_?֟1 vl+~AܭES>aBsچr^= ;9紭^x3侂so+82f !p}>+I$TUsJ=GAw"&e  **y|셱B U/OpKf_<\^\UX9;]Q(SR2{ Jyemc 3f e!|կ!@ss1"Mge[7(*{KE1k҅s j!hh 4l_m1pZOL턠ÇxY>N̟?Ç3~x'х ~1iL,uuuAXjL6*̛76kb92@Nf>!38TvJ }̙KJwoaÆ^'?-ZҥKmP;PsSoek .ͻȒ&klKf7g v P[cc}~;Oz>n9y.;GoCJ5ѩ!"x;=/gGpn%3P,شP(Ĝ9s:dض];&M͵ F!3'.cKe;\0>CqinNS^ܩ+gRZ"&B,i2nLu6mNåQUX̸@M0ztRvf?7Ӳ>ԥ~N48ZK$x>N4+bphTՅh̘x~zm HTni4q8pcjqKsѐ5b oݕeP^rNÒf{>Y.4Àq)f{=ݽp!,iᒖZ&Pkeg}aaэ Ͼ>0-5l[J^|iR'?ibƲ]0NepH^j[y܈3L;ݲLLi8q=&e|.[m G #nэ !=`3*8<8A.ܚ}1N#b:֖!LHkѬ 'n$;31M]N ZKO Dfzm S]a W_#'Udp?İ Tߚ*#᭚4q[^>5Ͽ ˲7rHťy'7/_ .xf2%AFB-ϾqxpiH( j%&qǀ]%pi~&ݛgg N@7hcĔ&kZDvZ14)ES8֊wGmT MuwcʹRT .m-y}cdRUH ;xܱtx7ST8#{$/g0iLz{G+3(B@iŞnu F $q1 5d^wzȢ)qw~ųla(Uퟫw'7?9y<45S\KRT8Mu3 o8y9?],@m(GUݨj UBadTP0̶Zɴt{t1ߑavJK"^|/)PPד#ݗwES(<JT/"G:,AS\(bLQ_4tovT!Zr2! 3Ď '{}3># qw(}Sƚ*"mjC/ǡ=ZUND*.͍ YD>ڙKpi.\.7an۪vԗuv9_E0LuJuQ*LD&.pypmH=%]GHfO3i|Df $9} 2Link0t=͠`,%9d*z.-ct>Ht -hMu4e2 o8eU;`F G[QUsMvv2C&/GJ ر}̣$N}[(*BKd$eَi,4Յv|"GSz9 A a:dAL]c.'Eh]^Θ,b{:tt!=ϓX:3k*%#ast_6"j"j(lpbBD7t*kTFhux>ܚARb!Y8}%6axO4o8M4nCAa!(?A1W1,Щ?U64@$QS]4.iY5y%4j̈́(GK<4 pLӠ#󳫥97}s::/ZX$-<׭);|؛p%`^OqyQb:!cdKH)U+$ߏ~̿"rI$?k6U^w:ExDP QTq*?zS_PmAQR &r=# 'e#lzS4UHJ|iM4YJfםZs"m$]g ed4F(R!y: -د 4uLP(DKK -aE#-g \xʪ":y;ݚWoGRDB;#DD8?EX9ZɤRAҊobCmx"܂ a~jW!tHܨFU];.5Bϴ%, e?hh=L#`Bד'3fu#СCQ4׏oz2}5/Y}}x>O&i3HXXrit74k:oBl/Cg,,*B}Mi'϶={b' i.,ViL;uXNdl>踻7 G{LhNz-v}O泌/ZSK]-Ot*1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4{ UWUUUUUUUWUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUWꪪ$N  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PJU*ZRjUIURAj֡ R*UUBjAԃZjMj jOB֨( ֡_֡I-jA_TPPZZZI"D"D"D"DH"$H $$"D$H$H$D"DH$D".WWBWfW#1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???kG?k$??H?¿?????@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 15hPNG  IHDRc/IDATxml[U9Nl'vi$}JlhRBXZ,Ҿ *ZCċEYT^/@eZ@!fj2#t*-]hBC!MCHؾk;i)UrbIH]s՟9{l1(1 bCܵ(2E3٢EUx?q_M孝Ɏ? k֭B!y7wuuʕ+I&lڴy晋ظq#dG_O#'TB׮Jk4T߮+Hs֭[D"twwk]+V H@mm-@'OňF[oRgF-]Œ _8)x;֯__2{1*++W_vmmmqI$$IN8 /Pz,Z;TS&!&fh,b~:r9|0ʴ=wǏu]axx .pСթ?nFLMxQ(3㧻gfjD">c***Xx1K,!pOG}X,ÇygT+V8]]]3*UV, U]hN'|b̢51SKqLy?gϞ=|׳b ,YB(bӦMS*G!K/]Wћ@ξv PъևK[ ?}G]g6`o~I&y3>m۶tRΜ9ݻy5kikkcb16o|glBuu5===3|8hMzOEL~ dh>D ҊpvhwZX{u|_rJZ[[q{ꀟ~i*++eo$BSSxoF,BKѬz"|myb5\z/(㛣\_Ɓ uhiiKNݕ?ps).a?(]pQQJA0PNw)W|P~?ﾛUVF]]ݔBcFFFؿ?p%477SWW3W ˘huvJTE"qbH(JMso[I$^0{>Cιsؽ{7= 7@ `Y d,AFG RQQ ?r“SS"M*P(gga9r ˿}v8ǎcݺZP[[z,ZTEUU'/H]zz.3' Uo2iR1;E!vmFGG$ Μ9?Z忹n|ć%vɗ_~I$E3mcccGsyM+n[zrgH ϮT]5 ,w)H׺E9|,JG/?Y45v 3.7{i]ꮻ… 4 gϞBTY_@mm!äR#>=@什φ' S?7;@uD1ຮFGS 100Bygg++ _Avq3; 7Bzώ(+L'.62]U&q/zI1c m47&Kձ$p zS+&wœkhϲN8{ BkMu $++\7ev{\K@~룘hN+рvYٙ)?M[OR򭏂5K8<ƠJ8'?cV fn|v5(@b>*jً_¼xak@XkaM#Ix5 &$<šGXkaM#Ix5 &$<šGXkaM#Ix5 &$<šGXkaM#Ix5 &$<šGXkaM#Ix5 &$<šGXkajY<IENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT(4t UUUUUUUUUUUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP$E  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PIU_UOP/Bj֭j֡ jjAI&AA'֡kTP/P֤j /O__-iH?B$"D"D"DH"$H$H@H"D$H$D"DI"$D"DH?W#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???}}$??_@A@P)?r?r?r??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 16 PNG  IHDRc IDATxy|T眙LB;a D"E@DD@ĥK[֫^ۢVﭻk lib ,ٷ9ǙLْ ud9$w}+ B@ . $xLB< B&!!OI'A$ē dI2 $xLB< B&!!OI'A$ē dI2 $xL|?C|}p2!%nij`Ŕ HQO5UU thI} !N"n-/֭>fĝx֯/֭F۔&.=ZƑ#mJ\W}6o.dhx;oNm8kV6 sSu~hr^7yIM[myC\KSTTCmyE\6nɄ˥s /FۤZ<~`Vhĝx3Fĥx* WiZM[@hmaJ WEی%nk+:#f5q+!@eӡĭx=Eی&.& [Gd~7mF\5OffDی&.k rq%n6bϘ1I1jTfmM;V<,Y2[oKrʂmNp^mMgٲXi̛xWX~R CE3eJ5kx6M"#4Ϙai68?KNn^xAbQ"773͛'+|61MSCF3y+쫯d/[lᩧBt(>SJKKY~}lfv,'YX_Cd]Czz*N'_%'''ϙ?4|r0e1Ut;XzY,|s7<%ŕ޽y9p@יLR6gp 4z/H{(sAv͇~Ș1c-[}ue˲Im#:a᳍ggg}***x=ztPeAS<5Og ORuW=y~}}=/Yp!ں `H'V B<&dYgnՅ[uuϚ5k~i!K W] @ZlQt#N\nuߎ;ڿ-:3 <x: [³/eI;mVH:?OĵxbGx"[Gډ}wxppkFӵ`-Ap-\.<\pE`ך̕!kldRÌDcn9{x!)) Mp8>} 0`xGXx1u+7z j* rJo℀3pdŸj?.i+ov;BvZ>V_bc=p7h"M/?<~S5ONzLu˺^0hȽJ1uN]1d=_]g%q?oe˖;v4:wY,֬Y#.];g^rIVvP͓lMlur-oY\^_Uvۊz6kyuÆ {y(`WػIs!cPG7Gݶm<?>b_JEEgiﷰg@Hv튧_d3Bש- ZNj_+փ2=Lu Iez=lDG3T73i#0ᐟh&C&0 } gٞ?Ѱ9a8Ȳ$I<PTMOPuw[&LxfM3Z #G4O_EFdn[0[ut;p8F73e"F ]h-:̡NT>ZA5dIFG*:Gwt;p:;jx<䗈Iy[wo}]=rKv )(.t_;j\m4i&gy&䟣+3l_־^+l&$CG5t]C8+ ^Iⳇ} ={}{ ͒b|闻h1aϷiwR[_I3e //FXCecѶUw{=OS羣T<ó;m;ׁ!\g u 3eE6l|ΖŏqUF! +M[,@skFϝvǎqi6:vg NW=ir5ᅿŋu $'bw} gj{@7bV3ӱæ:AlݺӞ(%ڬ٫ ']{B&Kޡ%Àޙ$a1[#A@Zޜ) I;jWs߲jC'SZYp o|G{ٲ%^rLIBj+ڗZ{%.⳯&8]yI6gOK( l!g| UuQgS }[/}S/2{MW-ŭ:qҋ/;P77ڢ {_x"Gz>$lǴMfdܪNC%ɬt. ,$E*jl0<;jwPSפf_͖w"R~,򄿘/UBu0M3ӧ/f3> !tf\ t]^ckWrO.HNfaٰ͜+?ùTՔQ| ofv7e!e)}c_n\j)[6ӴH Di_<󧭠O߾ݛʪrΖ˅; $cGLSol6cIJ")) DUe9e%TT*g$E3͖ƴ}c ݩPl 3cFg-~ەͼi+߯?f3|wU58MI4UkI.ۏB$KH2lx Y*\.N LeQ\( IwԐw Mƶmu[x#(x|‘)s|HJpl1gSQ}:GU ^W oaxև*tɒFsi[lBFGg*xN;€>zLHegȐLOYikaJIP^]t Q 7eet,+d$!ZR5!'-?g4/B2F2\OJr7U)>}AB$!T(F_:(jbmCvMV> [3<A1pk%+$FLyit姩WP^UBI_ubN &wyOhxxܐ68ڟLYgʊu!dI9[qgsc`=< zdNl2sKj=6ؽe8O06=O l<կPo ې2dt^$YQdϹF>x.tOgalr$/`R,3l7 a(nՉ5lEBGޙp#=òHF+!Gdk?ͳoW!Qk$̦$?VK/ٕ@w=b HwPdIR|)l%Im/[i7#!5܇DMaw#ÐѼah6eҨzpbL& ي5)Hud6_FYH_.!\q*>v}Ms7CeQH2uUF7=z$$K2IHv'[o$IWnlQ%s!$(8 3/n,cV]4MmT[Z'R"g֤k-`eݼeH3^N9d"8Tӓ&s;,Ch9hrIehni,+\DfL9+<7mfK>y_}tٍ[4e0Ĝx+ ݳP kB\I1|;d}weO*E12%ς.t7wPQs<}mS͖?^}.O~ ʓޫ.|$X,_uO @$t=t{æbN,{/c/{ՅF&qfL5 Httg,jY3`зlXl bʫKرKIHν7> >͞DW/vQ5FM؝])+T͍rle,K1PypBh{&uTז1y|ϱSх_}ݡ5?']9S~dkwݙϿ~MW32t R{ǡeVǨy2E38nQq[QS J2+*wfpU|5*xT]v"I UeW֓n}l /ͳ<&n[qzt]u. q|C׽jA~lڻ!tNvPY{[\F"n]JF9hB X<4%tOM%55 ͆:NۅaK pk*FC-rOqԚp Oj’Kݍ6\ @UCkڻx4Յ=_;_RzGRhw8j]~cd0yج64]^KUm.Îl 7d.4Yn W>gѓm^PYi̦$)>7b5ģjn*j Etǁ$ h-ΔqW"^CUu).Չevj.SkJ`4~A-?F3bFf Sp|/H baլl-O wfHB]N<g뛾B`6[w uO%K Jܪ ]4o/!| X6df)](3Ӝ';e$IujP5WH.'z,&OV 5ByFe悷 UB*p\x%Y™ΔѷW.z㆑d8 0] $b"bCfME17lJ'Zu_qTTu5M9c.*lKVQp|ObZ+bb6YEpFa-#xn\t{IzEj]`R,#yYjɂll23e"_ڋ][j ߍ0 hcp 2 SbO?bPAT W=%G)>WvIF@rx/WuGGG10 ;I1)f̦${E:9ӻǠf@` .TM w3~ĬlK֤TX#5хA4[BFyݳz&ycՐش}#!tpgqm4Ebc6i1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT )4y UUUUUU_⪪UUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU$L  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZPTU$UJ AA?Z֡Z'P֡RBB֡kMjAj $$H$D"D"D"DH$D$H"DH"$H"H"$D"DH(WWBW#OUUUUPUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUULtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???vv$??@iPp=?@ ?@ ?@ ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 17PNG  IHDRcIDATx{|Tϙf Bb UdA͊JrO{nqKܗSmQRZSoXPT!\$&29qLf LL79s3HҤnҤ.i񤉛xMZBRuƥWUv#M)#KO0hi"H)ۉ4Qx^_fi"Hd򓟼mi"H ,Y2,n9ϝw^KNelpݮ y,S|tS=HVM+QZ:%KP_/v'%ɚ53XS3c?EMʉ˘8r0zk7](IIXh"fhrst=Ƴ|EAJ'IJeW3wn @߭B$SUYv8$IV, p(՝ n8υ*-\X~>R6Ӑ(Vব,}>nۙ!DJ0wG]^bIzuqM{;TϿzxr"//deHH?\vYڹ&e#(?lڴ)|O47wJ[[K͐hMJ 477(((NE}=ƍ`,w=cf?@Ib; 餱 L( tЁs9Y,^\Nkk;G0u8fOAA>EzPl[O>\.9‘@ b E:! mlvt|]JF̡KQHƌA~~."xעOz%o2$e]~]d`+(TW"`FȦh$ƍ`\Nt3qb!j&&D;{XVv9sp6 pccǎn嗿0ww}C_i)Duw7WVREjn>63dųa;Fqqq<ʑ#MQ?L?wQutio[:Ǐ tbUT g5"eH@6]C0z+qkn3S'Ȋ+=Ӊb/F:;obq#ӧe3HY_Eˁ+2|x6a//@ ϿAEEE\ Nc^owWxqP\@V/FNNSpt:ٳg\sM3S}FFJĐǎ5sl3g9v$ xټy3,**_8pCHZ[==jw}kؒ}Y(?'Nȳg*9 $LdJbg^:a6z-FW\~~_[hj(y7q:7ް4E!+#1=6HֻKvvvBm*Rƴf]'q~R<OG?QB򮪪#0GWb^裏?~r-08j>('w'`S2ΝKUU֭.ScX(,\FlNq%-mơC,oʕ|yZEH"@Q[@CC+--nZZnHb+ġCX~}Lgݺu̙3o>LGGKK](6@H6ŭ#kv{Ut=i~L$xoNEE< FBUpjii5of{{;|+Voo?y]XDYTd=C9s@pLNjcR>{vtyٽ{7 ;w`0緿m/\x~_q/Fuu5Vg5aLe߲e ;P$2),vT3g_vw>shXM諸3x'=' &\GQ(=d~\ػw/^xOJKGQP0<#$ɱt޺3s>Y[[uly*^#^T>&W\yA^ӧO6'M-/{ 7Xz꘯Yfܴiׯuuu.Ld7ĿyIrCKkܹG@^w]Z<ɗFc=5?eUU|s=',X 5C2jf\>,]T[{[ -'k$,-ZH_6nO=dp={׬Y?,s}f.hJ֖l޼iӦ/6ny)%w7vl :=W_Muu5NIƊ$Hh iK{1vᇻ4Bs)++anS:GITۖ=!6^]x1_׹Rqq>yy8 躗}vI=~mmm\m>رf:m`׮8yҥؿNIMHy)s4_!"pYteb[pBŕ@J1qݴ[b:/]8@ V"c<Su} iϟv Jkz$; Oi4Яb+J;Q{=::Rz%~!j *zhyBaJ h"}uH)Mh0ģI MӘ?QH؟MO2kG"iq[[zKGy ] u4-456q$8CP4Rߒ6MX\A:ODI5U P}՞m?)Aia۹*륅"^ 2*#A 4?ïz }DC>H)𜣭oKd&G|`i{Ed57$GUU/^_kdxKZۛra9B^RjJ0>$c f>)Aގγ%^Yl>x8kϗc(M]ԉ ïǟ&qxtt]"U$+ф=@02-"ՙ $$!P7^;^8Rg_8'/*('[:~rp} Y7.&,<' gmAp#+L\)7!/LH}Q<fO_I]Þ\[K4Di8,RJO^2h)[ae$hZ ^&)%GO 7;زjZDR|g>9JVyA{5]3K1ZM};N%c+p:\<`( :mŒcd#E?[qdLƸ[(h jQ֥N{Z02̫z(:̙ry$"O_c^[2̌ltWJ@%!%Rn<@02ojUTBJɋ׌b2gX4AM0FA_Z0d#"lZx19qS$gŁuO+_i=wgt6fyMFIL,IfF),J e*\lEVV Ns=\FF쒱dg恔:=mm:4bxځ!еP:nٙ3>ViF=@0:c]疍A+'\,T^Gy%hsጯrI\,LT":Oo9!EohɄq0Z2]DhͬeD0dNg wbӏE4d;xUE3qrm̹7^'>M<ϤHHL >nn^0tĊmVfK/r*:fġ8~Ջ߉@xE?}u#d8sO J,铖 cɖtMЬ5#N\9~.g&B(hfi^'-_h""n)fO/nSybN cEhCdzWDi2&al eEs)@Q c&EۍUCLVYe㧇 ,Dgfr2._Scn>;'%!`Z BV1;C'U U) ر(T ,\,n%N0DB`A׍5K5菚pwW 'S gi̹4X <&Zu}'u]O(#|{r,>]R i++ <~cnqSȁ.ZNB8Pa>ˑz0% TZ {~/BvO^8LH)Rζ_ćq xhnm2z!ƖK:7+~@:#hX3tE)%!6mR g@ml1ϊ>bH❌A(:Q6v[w0v) )AVFvRgӹxTM)A dΤ*FLݰnd%PR"`m/3T"@@VnkǑER"Eн(ڇ(ِLwJ;fƜ*B^;_K]c!sCanb  /}WjclR49.${\(B wjؖH!H)H B7~Y$,(:?آ?$B% %M.aid;k/S@~Of3_>άIENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4w UUWUUUUUUUUUUUUQUUUUUUUUUUUUUUUUUWUUUUEUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUT$J  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZPTU$UKZZ֡Z'P֡RBB֡kMjAj $$H$D"D"D"DH$D$H"DH"$H"H"$D"DH(WWBW#UUUTUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???ϊ$??v6$!@?lЮ?lЮ?lЮ??@@@x@x@ ???333333?333333???#~j????333333? 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Q\0u&bܳ#;p_f9ضMy%T G^_^x"FW}wy=>ȪBr 4TL_m uƬW$& imC*#i3jeUi + >U9$& GƻĺD; G;spӰǓ#i<*KKP`(Z%HYȑ4ĸ3@Jwn$ ?ȑ'!#aȑ'!#Gyr2raȑ'!#Gyr2raȑ'!#Gyr2raȑ'!ZIENDB`move=1000;blend=1000;3OYTB1%4$D  BUA֡*j֫ZU_Zj֡UBjP֪ jԃZjO_ B []jZԃZI RkR jBKH?-iH?j֡Zj֤PI/Z_j֡ VUPZP ֤ZZZP ?_j_R Zj'//j֤֡H"D"DH"$H$H$DI I$H"D$D"D"$"DI"$D $Ym,Bp fHIUUU$URI$J*U$"JJU@ʪI$@*""""JI$!BI$I$UU$H0`2I$DI$"%UHBUUUTDI$IDI$DDDD""""I HIUUU$URI$!JUI"""$UPI$DD! $$IBI$I$DDDDP5U$UUUI$"$UUUURI! "I$B$I"$""""OLtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES13OYT)4| UUUUUUU_UUUUUUUUUUUUEUUUUUUUUUUUUUUUUU_?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP$S AZj֠*CZjOT?Aj *UBT?j +P_U jԆ'ԟP_ZP_֠֯Z֤?PARAjMjCZP_i֩5Z֪ԟj *BRjj ֪j Aj /ZUAJ(T(TJ*Ԇ'Ԛ ֤B?/j jO֠ARA֠-iHZ$"D"D"DH"$H$H@H"D$H$D"DI"$D"DH?$WfW#?ILtbinding site for residue k a 408ac1)W1~binding site for residue po4 a 409ac2#( 1vbinding site for residue edo a 410ac3;>1vbinding site for residue peg a 412ac5A1vbinding site for residue peg a 414ac7z|1~binding site for residue peg a 415ac8!;; 1vbinding site for residue peg a 416ac9km1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES((1met->mse selenomethionine MOD_RESKK1met->mse selenomethionine MOD_RES^^1met->mse selenomethionine MOD_REStt1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1tbinding site for residue k b 408bc1!O1~binding site for residue po4 b 410bc3#( 1vbinding site for residue edo b 413bc51vbinding site for residue peg b 414bc6?N1~binding site for residue peg b 415bc7A 1vbinding site for residue pge b 416bc8)1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES,,1met->mse selenomethionine MOD_RESFF1met->mse selenomethionine MOD_RESQQ1met->mse selenomethionine MOD_RESyy1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES  1met->mse selenomethionine MOD_RESCC1met->mse selenomethionine MOD_RESVV1met->mse selenomethionine MOD_RESll1met->mse selenomethionine MOD_RES{{1met->mse selenomethionine MOD_RES11FJ4 //r uփUZZօQQUZUWZUkkWj*?ZEGUAZ֡jZօQQUZUWZUkkWj*?ZEGUI$$$I$$$I$$$I$$$l fUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUVDDDFDDjDDDDFF?*jDDDjGFDD@DDDFFF?(FFDDDFjDD?DDDk*DjDoFDDDF$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$I$@binding site for residue tlm a 500ac1)1binding site for residue tlm b 501ac2)*1binding site for residue tlm c 502ac3)1binding site for residue tlm d 503ac4)*1?333333?333333?333333???????@???0K;G?J3-oxoacyl-[acyl-carrier-protein] synthase i; chain: a, b; engineered: yes3OYT3oyt P 21 21 2BLJB9Bl???ab??? AAMHHHHHHHHMHHHHHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWaa                     pff fffffffff ffff fffffffffffff , ffffffBffffffff Yffff ffffffffffffffffffffffffff ffff fffpppfpffffffff fffffffff ff fffffffff$fffffff ffff fff ffffbb                    pff fff fffffffff ffff fffffffffBffff fffffffmffffffff ,ffff ffffffffffffffffffffffffff Bffff fffffffff fffffffff ff fffffffffffffffff ffff ff fffaak' aapo4s aaedo`Xedo1,2-ethanediolaapegdd headeXpegdi(hydroxyethyl)etheraapeg2 Xpegdi(hydroxyethyl)etheraapeg3 Xpegdi(hydroxyethyl)etheraapeg4Xpegdi(hydroxyethyl)etheraapeg5Xpegdi(hydroxyethyl)etheraapeg6Xpegdi(hydroxyethyl)etherbbk' bbpo4s bbpo42s bbedo`Xedo1,2-ethanediolbbedo2`Xedo1,2-ethanediolbbedo3`Xedo1,2-ethanediolbbpegXpegdi(hydroxyethyl)etherbbpeg20Xpegdi(hydroxyethyl)etherbbpge Xpgetriethylene glycolbbpg4  Xpg4tetraethylene glycolbbpg42  Xpg4tetraethylene glycolawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253awa254awa255awa256awa257awa258awa259awa260awa261awa262awa263awa264awa265awa266awa267awa268awa269awa270awa271awa272awa273awa274awa275awa276awa277awa278awa279awa280awa281awa282awa283awa284awa285awa286awa287awa288awa289awa290awa291awa292awa293awa294awa295awa296awa297awa298awa299awa300awa301awa302awa303awa304awa305awa306awa307awa308awa309awa310awa311awa312awa313awa314awa315awa316awa317awa318awa319awa320awa321awa322awa323awa324awa325awa326awa327awa328awa329awa330awa331awa332awa333awa334awa335awa336awa337bwbbwb2bwb3bwb4bwb5bwb6bwb7bwb8bwb9bwb10bwb11bwb12bwb13bwb14bwb15bwb16bwb17bwb18bwb19bwb20bwb21bwb22bwb23bwb24bwb25bwb26bwb27bwb28bwb29bwb30bwb31bwb32bwb33bwb34bwb35bwb36bwb37bwb38bwb39bwb40bwb41bwb42bwb43bwb44bwb45bwb46bwb47bwb48bwb49bwb50bwb51bwb52bwb53bwb54bwb55bwb56bwb57bwb58bwb59bwb60bwb61bwb62bwb63bwb64bwb65bwb66bwb67bwb68bwb69bwb70bwb71bwb72bwb73bwb74bwb75bwb76bwb77bwb78bwb79bwb80bwb81bwb82bwb83bwb84bwb85bwb86bwb87bwb88bwb89bwb90bwb91bwb92bwb93bwb94bwb95bwb96bwb97bwb98bwb99bwb100bwb101bwb102bwb103bwb104bwb105bwb106bwb107bwb108bwb109bwb110bwb111bwb112bwb113bwb114bwb115bwb116bwb117bwb118bwb119bwb120bwb121bwb122bwb123bwb124bwb125bwb126bwb127bwb128bwb129bwb130bwb131bwb132bwb133bwb134bwb135bwb136bwb137bwb138bwb139bwb140bwb141bwb142bwb143bwb144bwb145bwb146bwb147bwb148bwb149bwb150bwb151bwb152bwb153bwb154bwb155bwb156bwb157bwb158bwb159bwb160bwb161bwb162bwb163bwb164bwb165bwb166bwb167bwb168bwb169bwb170bwb171bwb172bwb173bwb174bwb175bwb176bwb177bwb178bwb179bwb180bwb181bwb182bwb183bwb184bwb185bwb186bwb187bwb188bwb189bwb190bwb191bwb192bwb193bwb194bwb195bwb196bwb197bwb198bwb199bwb200bwb201bwb202bwb203bwb204bwb205bwb206bwb207bwb208bwb209bwb210bwb211bwb212bwb213bwb214bwb215bwb216bwb217bwb218bwb219bwb220bwb221bwb222bwb223bwb224bwb225bwb226bwb227bwb228bwb229bwb230bwb231bwb232bwb233bwb234bwb235bwb236bwb237bwb238bwb239bwb240bwb241bwb242bwb243bwb244bwb245bwb246bwb247bwb248bwb249bwb250bwb251bwb252bwb253bwb254bwb255bwb256bwb257bwb258bwb259bwb260bwb261bwb262bwb263bwb264bwb265bwb266bwb267bwb268bwb269bwb270bwb271bwb272bwb273bwb274bwb275bwb276bwb277bwb278bwb279bwb280bwb281bwb282bwb283bwb284bwb285bwb286bwb287bwb288bwb289bwb290bwb291bwb292bwb293bwb294bwb295bwb296bwb297bwb298bwb299bwb300bwb301bwb302bwb303bwb304bwb305bwb306bwb307bwb308bwb309bwb310bwb311bwb312bwb313bwb314 _mse  _lys      _arg   Eala  !" Eval"!#%("$#"&'%%) Eile#)(*,0)+*)-.,/,-1 _thr*10247132156448 Egly2879;8:9<  Eleu9<;=?C<>=<@?AB@@D  Egly=DCEGDFEH  EileEHGIKOHJIHLMKNKLP  EvalIPOQSVPRQPTUSSW  Bser QWVXZ\WYXW[Z] _ser X]\^`b]_^]a`c _ile^cbdfjcedcghfifgk Bglydkjlnkmlo _asnlonprvoqposrtussw _asnpwvxz~wyxw{z|}{{ Hgln x~ Hgln  Hglu  Hval Hleu Hala  Hser  Hleu Hgln  Hglu  _gly _arg  _ser  _gly! _ile" Ethr# Ephe $ _ala % Hgln          & Hglu ' Hphe " !! #( Hlys #"$&+#%$#'&(')(*),) Hasp$,+-/3,.-,0/12004* Hala -4357846549+ _gly598:<9;:=, _mse:=<>@D=?>=A@BACBE- _arg >EDFHOEGFEIHJIKJLKMNLLP. _ser FPOQSUPRQPTSV/ _his QVUWY_VXWVZY[\Z]Z^[^\]`0 EvalW`_acf`ba`deccg1 Etrp agfhjtgihgkjlmknkoplomnqmrospsqru2 Bglyhutvxuwvy3 _aspvyxz|y{zy}|~}}4 _valz5 _lys 6 _leu7 _gln 8 _ser 9 _glu : Hpro; Hlys < Hasp= Hleu> _ile? _asp@ Harg A Hlys B HvalC HleuD Garg          E Gphe F _mse! "G _ser "!#%'"$#"&%(H Hasp#(')+/(*)(,+-.,,0I Hala )0/13402105J Hser 15468:576598;K Hile6;:<>B;=<;?@>A>?CL Htyr <CBDFNCEDCGFHIGJGKHLILJKMLOM Hala DONPRSOQPOTN Htyr PTSUW_TVUTXWYZX[X\Y]Z][\^]`O HleuU`_acg`ba`dcefddhP Hala ahgiklhjihmQ HmseimlnptmonmqprqsruR Hgln nutvx}uwvuyxzy{|zz~S Hglu v~}~~T Hala U HileV Hala W HaspX Hser Y _glyZ _leu[ _ser \ Hasp] Hser ^ Hgln _ Hval` _ser a _asnb _phe c _arg d Eser e Eglyf Eleu       g Eval    h _val!! "i _gly "!#%&"$#(j _ser #'#(%)-&*.1'+1(,)*'/(0-.2k _gly )*21352436l _gly36579687:m _gly7:9;=:<;>n _ser ;>=?AC>@?>BADo Hpro?DICEGJDFEDHGICHKp Harg EKJLNUKMLKONPOQPRQSTRRVq HasnLVUWY]VXWVZY[\ZZ^r Hgln W^]_af^`_^bacbdeccgs Hval_gfhjmgihgkljjnt Hala hnmoqrnponsu Hglyosrtvsutwv Hser twvxz|wyxw{z}w Haspx}|~}~}x Hala ~y Hmsez Garg { _thr| _pro} _arg ~ Hgly Hleu Hlys  Hgly Hval _gly _pro _tyr  Hmse Hval Hthr Hlys       Hala        _mse     ! Gala ! "$%!#"!& Gser "&%')+&('&*), Hgly',+-/,.-0 Hval-0/136021045337 Hser 1768:<7987;:= Hala 8=<>@A=?>=B Hcys >BACEGBDCBFEH HleuCHGIKOHJIHLKMNLLP Hala IPOQSTPRQPU _thrQUTVX[UWVUYZXX\ _proV\a[]_b\^]\`_a[`c _phe ]cbdfmcedcgfhigjgkhliljkn _lys dnmoqvnponrqsrtsutw _ileowvxz~wyxw{|z}z{ _lys x~ _gly _val Easn Etyr  Eser  Eile Eser  _ser  _ala  _cys  _ala  Hthr Hser  Hala  Hhis  Hcys  Hile Hgly Hhis             Hala  Hleu Hglu $ ! "#!!% Hleu%$&(,%'&%)(*+))- Hile&-,.04-/.-1203015 Hgln .5468=576598:9;<::> _leu6>=?AE>@?>BACDBBF _gly?FEGIFHGJ _lys GJIKMRJLKJNMONPOQPS _gln KSRTV[SUTSWVXWYZXX\ _aspT\[]_c\^]\`_ab``d Eile]dcegkdfedhigjghl Evalelkmorlnmlpqoos Ephe msrtv}sutswvxywzw{x|y|z{~ Eala t~}~~ Egly Egly Egly Eglu  _glu  _leu _cys  Htrp  Hglu  Hmse Hala  Hcys  Hglu  Hphe  Hasp Hala  _mse _gly _ala     Bleu        _ser   _thr  _lys  !#( "! $#%$&%'&) _tyr !)(*,4)+*)-,./-0-1.2/201325 _asn*5468<576598:;99= _asp6=<>@D=?>=A@BCAAE _thr>EDFHKEGFEIJHHL GproFLQKMORLNMLPOQKPS Gala MSRTVWSUTSX Glys TXWY[`XZYX\[]\^]_^a _ala Ya`bdeacbaf _ser bfegikfhgfjil _arg glkmovlnmlpoqprqsrtussw _thrmwvxz}wyxw{|zz~ _tyr x~}~~ Basp _gln  _asp _arg  _asp _gly Bphe  _val Bile Bala  _gly Egly Egly Egly Emse Eval Eval Eval Eglu           Eglu  Hleu  Hglu  !#( "! $#%$&'%%) Hhis !)(*,2)+*)-,./-0-1.1/03 Hala *3246735438 Hleu4879;?8:98<;=><<@ Hala 9@?ACD@BA@E Harg AEDFHOEGFEIHJIKJLKMNLLP _glyFPOQSPRQT _ala QTSUWXTVUTY _his UYXZ\bY[ZY]\^_]`]a^a_`c _ileZcbdfjcedcghfifgk _tyr dkjlnvkmlkonpqorosptqtrsutw Eala lwvxz{wyxw| Eglu x|{}|~}| Eile} _val Egly Etyr  Egly Eala  Ethr  Eser   _asp  _gly  _ala   _asp _mse _val _ala  _pro _ser  _gly Hglu  Hgly Hala    Hval           Harg   Hcys ! " Hmse"!#%)"$#"&%'&('* Hgln #*)+-2*,+*.-/.01//3 Hmse+3246:3543768798; Hala 4;:<>?;=<;@ Hmse<@?ACG@BA@DCEDFEH _ala AHGIKLHJIHM  _glyIMLNPMONQ! _valNQPRTWQSRQUVTTX" _aspRXWY[_XZYX\[]^\\`# _thrY`_acf`ba`deccg$ _proaglfhjmgihgkjlfkn% _ilehnmoqunponrsqtqrv& _aspovuwy}vxwvzy{|zz~' Etyr w~}~~( Emse) Easn* _val+ _his , _gly- _thr. _ser / _thr0 Hpro1 Hval2 Hgly3 Hasp4 Hval5 Hlys 6 Hglu 7 Hleu8 Hgly   9 Hala           : Hile         ; Harg                        < Hglu       "         !   #= Hval  # " $ & ) # % $ # ' ( & & *> Hphe  $ * ) + - 4 * , + * . - / 0 . 1 . 2 / 3 0 3 1 2 5? _gly + 5 4 6 8 5 7 6 9@ _asn 6 9 8 : < @ 9 ; : 9 = < > ? = = AA _asn : A @ B D H A C B A E D F G E E IB _thr B I H J L O I K J I M N L L PC _pro J P U O Q S V P R Q P T S U O T WD Eala Q W V X Z [ W Y X W \E Eile X \ [ ] _ c \ ^ ] \ ` a _ b _ ` dF Eser ] d c e g i d f e d h g jG _ser e j i k m o j l k j n m pH Gthr k p o q s v p r q p t u s s wI Hlys  q w v x z  w y x w { z | { } | ~ } J Hala x  K Hmse L Hthr M _gly N Bhis  O _ser P Gleu Q Ggly R Gala S Hala T Hgly U Hval V Hhis  W Hglu  X Hala Y Hile Z Hphe  [ Hser \ Hleu  ] Hleu               ^ Hmse        _ Hval              ` Hglu       !            "a Hhis   " ! # % + " $ # " & % ' ( & ) & * ' * ( ) ,b _gly # , + - / , . - 0c Ephe  - 0 / 1 3 : 0 2 1 0 4 3 5 6 4 7 4 8 5 9 6 9 7 8 ;d Eile 1 ; : < > B ; = < ; ? @ > A > ? Ce _ala < C B D F G C E D C Hf _pro D H M G I K N H J I H L K M G L Og _ser I O N P R T O Q P O S R Uh _ile P U T V X \ U W V U Y Z X [ X Y ]i _asn V ] \ ^ ` d ] _ ^ ] a ` b c a a ej _ile ^ e d f h l e g f e i j h k h i mk _asp f m l n p t m o n m q p r s q q ul _asn n u t v x | u w v u y x z { y y }m Bleu v } | ~ }  ~ } n _asp ~ o Gglu$ p Ggln  q Gala r _gln  s _gly t _mse u _asn v Bile w _ile x _thr y _glu$ z _thr { Ethr | Egln                 } _arg               ~ _glu                    _leu     ! %    " ! # $ " " & _thr  & % ' ) , & ( ' & * + ) ) - Ethr ' - , . 0 3 - / . - 1 2 0 0 4 Eval . 4 3 5 7 : 4 6 5 4 8 9 7 7 ; Emse 5 ; : < > B ; = < ; ? > @ ? A @ C Eser < C B D F H C E D C G F I Easn D I H J L P I K J I M L N O M M Q Eser J Q P R T V Q S R Q U T W Ephe  R W V X Z a W Y X W [ Z \ ] [ ^ [ _ \ ` ] ` ^ _ b Egly X b a c e b d c f _phe  c f e g i p f h g f j i k l j m j n k o l o m n q _gly g q p r t q s r u _gly r u t v x u w v y Ethr v y x z |  y { z y } ~ | |  Easn z   Eala  Ethr  Eleu  Eval  Emse  Earg   _lys   _tyr   _gln   _lys    _mse   _lys    _arg    Eala   Eval         Eile          _thr               _gly           Eleu                !  Egly  ! " $ ! # " %  Eile " % $ & ( , % ' & % ) * ( + ( ) -  Eval & - , . 0 3 - / . - 1 2 0 0 4  Bser . 4 3 5 7 9 4 6 5 4 8 7 : _ser 5 : 9 ; = ? : < ; : > = @ _ile ; @ ? A C G @ B A @ D E C F C D H Bgly A H G I K H J I L _asn I L K M O S L N M L P O Q R P P T _asn M T S U W [ T V U T X W Y Z X X \ Hgln  U \ [ ] _ d \ ^ ] \ ` _ a ` b c a a e Hgln  ] e d f h m e g f e i h j i k l j j n Hglu  f n m o q v n p o n r q s r t u s s w Hval o w v x z } w y x w { | z z ~ Hleu x ~ }  ~  ~   Hala    Hser   Hleu   Hgln    Hglu    _gly   _arg    _ser   _gly  ! _ile  " Ethr  # Ephe   $ _ala  % Hgln   & Hglu   ' Hphe   ( Hlys               ) Hasp       * Hala          + _gly         , _mse      !          "- _arg   " ! # % , " $ # " & % ' & ( ' ) ( * + ) ) -. _ser # - , . 0 2 - / . - 1 0 3/ _his  . 3 2 4 6 < 3 5 4 3 7 6 8 9 7 : 7 ; 8 ; 9 : =0 Eval 4 = < > @ C = ? > = A B @ @ D1 Etrp > D C E G Q D F E D H G I J H K H L M I L J K N J O L P M P N O R2 Bgly E R Q S U R T S V3 _asp S V U W Y ] V X W V Z Y [ \ Z Z ^4 _val W ^ ] _ a d ^ ` _ ^ b c a a e5 _lys  _ e d f h m e g f e i h j i k j l k n6 _leu f n m o q u v n p o n r q s t r r x7 _gln$ o w o x u y } v z ~ w { x | y z w  x } ~   8 _ser y z  9 _glu   : Gpro  ; Glys   < Gasp  = _leu  > _ile  ? _asp  @ Harg   A Hlys   B Hval  C Hleu  D Garg   E Gphe  F _mse  G _ser        H Hasp  I Hala J Hser  !K Hile! "$(!#"!%&$'$%)L Htyr ")(*,4)+*)-,./-0-1.2/201325M Hala *546895765:N Htyr 6:9;=E:<;:>=?@>A>B?C@CABDCFO Hleu;FEGIMFHGFJIKLJJNP Hala GNMOQRNPONSQ HmseOSRTVZ[SUTSWVXWYX]R Hgln$T\T]Z^b[_cl\`l]a^_\d]ebfcgdhjeikfgfgmS Hglu ^_mlnpumonmqprqstrrvT Hala nvuwyzvxwv{U Hilew{z|~{}|{~~V Hala |W HaspX Hser Y _glyZ _leu[ _ser \ Hasp] Hser ^ Hgln _ Hval` _ser a _asnb _phe c _arg d Eser e Eglyf Eleug Evalh Eval  i Egly       j _ser   k _glyl _glym _gly n _ser  !#% "! $#&o Hpro!&+%'),&('&*)+%*-p Harg '-,.07-/.-1021324356448q Hasn.879;?8:98<;=><<@r Hgln 9@?ACH@BA@DCEDFGEEIs HvalAIHJLOIKJIMNLLPt Hala JPOQSTPRQPUu HglyQUTVXUWVYv Hser VYXZ\^Y[ZY]\_w HaspZ_^`bf_a`_cbdeccgx Hala `gfhjkgihgly Hmsehlkmoslnmlpoqprqtz Garg mtsuw~tvutxwyxzy{z|}{{{ _thru~| _pro} _arg ~ Hgly Hleu Hlys  Hgly Hval _gly _pro _tyr  Hmse Hval Hthr Hlys  Hala  _mse Gala  Gser  Hgly   Hval           Hser   Hala  Hcys ! " Hleu"!#%)"$#"&%'(&&* Hala #*)+-.*,+*/ _thr+/.025/10/34226 _pro06;579<6876:9;5:= _phe 7=<>@G=?>=A@BCADAEBFCFDEH _lys >HGIKPHJIHLKMLNMONQ _ileIQPRTXQSRQUVTWTUY _lys RYXZ\aY[ZY]\^]_^`_b _glyZbacebdcf _valcfegilfhgfjkiim Easngmlnptmonmqprsqqu Etyr nutvxuwvuyxz{y|y}z~{~|}~ Eser v Eile Eser  _ser  Gala  Gcys  Gala  Hthr Hser  Hala  Hhis  Hcys  Hile Hgly Hhis  Hala  Hleu Hglu  Hleu Hile         Hgln  _leu  _gly !# "!$ _lys !$#%',$&%$(')(*)+*- _gln %-,.05-/.-102134226 _asp.6579=6876:9;<::> Eile7>=?AE>@?>BCADABF Eval?FEGILFHGFJKIIM Ephe GMLNPWMONMQPRSQTQURVSVTUX Eala NXWY[\XZYX] EglyY]\^`]_^a Egly^a`bdacbe Eglybedfhegfi Eglu fihjlqikjimlnmopnnr _glu jrqsuzrtsrvuwvxyww{ _leus{z|~{}|{~ _cys | Htrp  Hglu  Hmse Hala  Hcys  Hglu  Hphe  Hasp Hala  Gmse _gly _ala  Bleu _ser  _thr _lys  _tyr            _asn _asp _thr "%! #$""& Gpro &+%'),&('&*)+%*- Gala '-,.01-/.-2 Glys .2135:243265768798; _ala 3;:<>?;=<;@ _ser <@?ACE@BA@DCF _arg AFEGIPFHGFJIKJLKMLNOMMQ _thrGQPRTWQSRQUVTTX _tyr RXWY[cXZYX\[]^\_\`]a^a_`bad BaspYdcegkdfedhgijhhl _gln elkmotlnmlpoqprsqqu _aspmutvx|uwvuyxz{yy} _arg v}|~}~} _asp~ _gly Bphe  _val Bile Bala  _gly Egly Egly Egly Emse Eval Eval Eval Eglu  Eglu  Hleu Hglu$      Hhis        Hala   Hleu" !# Hala #"$&'#%$#( Harg $(')+2(*)(,+-,.-/.01//3 _gly)32463547 _ala 4768:;7987< _his 8<;=?E<>=<@?AB@C@DADBCF _ile=FEGIMFHGFJKILIJN _tyr GNMOQYNPONRQSTRURVSWTWUVXWZ Eala OZY[]^Z\[Z_ Eglu [_^`bg_a`_cbdcefddh Eile`h