,!3.6-1h/data/swissprot/ 3H5Q.pdb3H5QA_ConSurf_DB_pipe.pdb 1BRW.pdb[html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Crystal Structure Of A Putative Pyrimidine-Nucleoside Phosphorylase From Staphylococcus Aureus[/h3] [p]I.A.Shumilin, M.Zimmerman, M.Cymborowski, T.Skarina, O.Onopriyenko, W.F.Anderson, A.Savchenko, W.Minor, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3H5Q" target="blank"]3H5Q[/a] [small](deposited on 22-APR-09)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Consurf" --] [a name="5" href="#_"]Consurf[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Homolog superposition" --] [a name="6" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1BRW.pdb3H5Q a_3H5QB13H5QA_ConSurf_DB_pipe.pdb3H5QB1  1BRW3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn X^*+%w۲Hľ禛#!ǣضa@eA]]5==*{e2Mkͫ'A>͙*_$ J 78^~|Q[۩|}TVNپJ}oijdGn`!L()\l&!H à2D.}.bxO el6x R9WW.n]+{΢8gtt.moE &=K+gG32c|ܣs3ݮ?v ~ߜTv>)K[OQU%9att 59Fm7IO0>>Rg}Kvs O*\#s8'JIΜ 5!RGVb lZqJ'u &-ֵfddQgQKjMwĸMznaCފJ@[<Voo8txFP}?56lh+D!oDzCGC2%tf%߿U47+폿mvM&zWs|w3JOw~gDlQxZZΐfP 'XN$ⱡ@@r9{ n(b#38F br`בL΅rU~{b⹥$[f3(#\.ˁS ^{׷hj yxֲۣQ;ŅkBk;K7BC 6/;'>#47"R~{%F**b/=l;}=|_H?(RJyh-ٵkJlx D8rຜ+#ˣ-mť1H"޽Ctu }9Ғ%.y.غF7) \Vbڰa.?|~D }47رZ,d;VOwwp߱cӧGY"Ӑh[N?&?[`sn219HDk  W_A8<]+V hl+9`Ζ%#`ӦXtA1#z o֭kq$lgG{Kr{qggq1R.Rz<K.Dד֥;HuuE in ߿P_G22&ddlVHP$Q)lЂRYඏ\k' ^?#G(F7fj*z[\8>JEX1vobMHi@W^=sO\ˎ3ACCl~ݮ+xSJkmGR:g'w3B4عOA[볂e2K__^m,%n_.Yk/h4惤;L&}&sϺu坮+;jkcbjʢll<]|CJdFG3٬&MzDSٽG|QA,2A*q NH16n.Cuo$2 wgŊ,i#=+_qQ hn wq\'SAߪZ%K_T'#5ve`P?e{LLDI05eɠ(7zm|c|?$_A'~0k_%ƞ[__/+0]))9wGnuMQ# {1O+Œ%5IXpTܛL `˖N-}k4mfݺf"0ZkHlp*nNXdN{:Aee[;ʟb9P<YzzXl.'p])Z[ϺRNÇOkLM)4Q _Jɰo2 XmD"XveS__ʕJ#gEpnwsTъYwtXk&3fx<-kA(}'?!%DA̒iￌ JzyBJG?WO ,U7,w`ٲ"Oc0 n?vw0[75#LrvlY{3 tME^yF dyEcd: :* q}{dp^rr;3wߓ yU~C.7:Ut\s,kp;z]߯nlcpV}_LeS恷 $y/=h |ҩMoצ"0nɄ':mGh6a01 $Itt*yQ@`@ "qr9Q]N~_K6(qN#~ѐsnI6tmC%'8Sr^kV7ٟ0o׃h1v!oJn .~ϏRj((9t-2Ak;[ #ΰ7@Qryq)]~<1?codgfp!8wo*}2߁^4@5_ٌl`Ɉ>ˤ%/:( &޻=,)t~ }Gr[<K˾(]ߺHB8{9LR[3"ip^j#$ _ D.7.XNd\''ݎd`sFQ-7nB^Ib0X`=㈨e8z7UKm-ۙ vn~sP}U~˶>"kŠ`0Ĩ(>2 zrҳIɷ{F6^<z݁N`#Aod T RbǬ:{2ԩװ~wM>P(=7*-#t+Y?%,(6yr֌)/b! l-S^-[ 4+^]k$/aaϲko^Bčb'\3ӃCa Q^ǐDn؄ZmRU}wr}wb0WV*&\@h&""n>ײ"ooazõ@~ktvC׽Qa&~0qߥ/YH +d(+."J`ۊ`Gaȑ|ԪU^zPSS,a4-oS-bΣ#C:_EdD軀3uk %yPGutCQt]П{[go[PQ:\cqbϢE8!4 R'Xt|Kv<"D" !:X4bs|(U(_|4l}²QP-scߒmͤyδ1KT8̽p1hե1eʱcrp6 M՘4}^wt(|;?~ʾkxya8o?EC;^~$;!(Wl{[^SfW=+_bژ 7"*tоi)CÎ{AIEzKNӑX"ϏUSCz^ 0I֪7;i.5 |&N!u?As)7DtDմ\>ðs@ ٻ/O NȑNүBq}bvn^y杼V,A%O>HKN,eE;visq>ނ Jc~wD`j '½<C8@%mDE8%ĞMRY.!Hԟ=pp`&D=uߣT\.6k7&IΝ6l_+2۞gW ~vj֯B3:mvzOΟn,ƭ:Wd8v x-9@0T3b激ĶxW*SŠ0ak6 q CQBDJ s=s6B,V.eʥnp3*Tdq \\*lp[rb!w3h|voZM۴aa躎a oչT}ՔPdzJn `9YB&?fE"OFLKЮcY"}db-3s|sy8m{ d_21_3[6a[OfAjԻ.?o Se//u9; ϼAdN ,,B&ONHQJېKA]̉c}CDd8zx_x~PtNn>ٽx۷Lǣt=m b ~V `2y"κͥ;1F30 . W]F{`ts]FZj5!NK>wؗ5)t#1`0|,C3%24ɗ.nbnq*Z}$ڀxLD8օH|g9 ݟ:/( |d+Dj)`:ADZ5t0{] ɀ>Nᓸ|aQ$_:KٵaEn"4hvk A߿X;e*vhG"b"1- qleD_JCl :'BLvW@bhVQAb7MR kUnÓ/p|9R> gNE隆1p7 {Žo0HJ8ǯ_W?'9TE$`}ؒ4@'߄3Z8]ِL`=77!n_x#:"ml6D/}~4&]GiFf{QDĐb}1XDCXB_=ezdۚK$g͒)\D?$+#^ƨLJl_Csb2|}QN|x #!TVvMGDlOL;^{2$=Ёù]@uNTJ+&Q߬?0dnLc {0ٌt2yY4D#".Sfq.ch⯟rOb49OEP2X7SncPD$@S\dJ^|(Qț@[|Q14s2=oV҄=KTtiʖHTk}jh.TYR~_X;b S/se+{MYHva69u|e{*TκCOxNn9jCAwDzom ӹO|@U2F˽U䭯ߴ5ne!`fĉ#L).9Eւ$\ץV̦?ӢmTV9 Muqan[ҾgH*?+b4o w_yrȋq(BD2VQVY%d 4voolLjr? vu׌ӽBÞ-P.CR32!iQEYfi w2p!St-!/z<>x;Xvu\*U\UDQ7FE{FTu6"a}Z0GD.Y' E =sфdM*\jt{x0l]'& Mǀǒy ސHdHvIafAjx 6t}x;ǃ():Gjܳ8/rx3njE`m2DLɶZk4x4;:Abd 31,~fTkv_YCA|p>‚Q$pIo(ּ/^CY62) WD ;0Z9uџ0{xD 1Hh!`Uu:Gl7HO pl8Up;7ѰY[~#~.TKZmDXw<=y_ :D +XሮXg)/y L2^ DprZ,!n>HggR騪<ӌYP7+"*R1e)S11["S]tMJ -%FTT&~UZwͿGz˅78#lP B'菬ÄGGC댐/0Oj3_xj<,ſMΆڅrZdz}pjQXx}"(X{GpQo{RۓI=t 2̝kE1S΍d%cR/F!A m7]F &*^mhD*Ii!Zr`wblAVB7VxQ,@L3VVэ@FM"ގ`s}iX&4={!SBnq3>aD`0nh#"&*2LF/I21gILG_pdPLF*ի+u> t"k3q.Hyxw>&"rk-JU[-T';;]͎t,=޲!kDu1XLl/cP!W6񤓎ƍJ8=2lqre6?6B&_!Y~nw!q<^eOE^3BJbU4\9<{OWẍ>v}(^ѸLʹS:D~X8{ܫڝNtE NJ–{i} \sҁa4NN]ЃsߓsHIŅ=^ ڰ|E ŸL x|Ql4(c5.!aD%NBd$iHHQ Xd5kql~t[aSXԌ;QKZqO $O~Dz,!!hE |p`THlXuyӅ<#S7{)\W0}zcz//',&R uoGԛ7)w渏UM|r+׽;j. |$B1=Pa5=Sqx lBF劉EDYtGQ@k-4Ucmd%%au۵ FX )Ȟ-dYG4<^yM$"޽qDuT]|5ApƏO%vة8ca/x2X!wRJssdFR w{لb0Z ܕH~{i,jU9AZBVY!'2B#VΟ&ZVzxA7@xNgߖ8r9 ]%'V(6xV?Ҿ_jR,^!_E600S;bKٲ<@*ԮQ):}6Dʮ-b;_DAA6!3HKD&":oC~#ӟp*vu ϰ UL&"yr3f"OGfdO.\Xn )/ɈbšJ!Pb_2-a,4xsO@Qr`BV* V!NPhXDavɃո&|BIskBN#5EHdp7ӯsK''aٜo܁, H7skߖ5ܰ'?b;Cj`wȟri hr) =+/B 2$'ϸyd]%Bz0"@rvdIuYXD'V884 p^~Lԉ;5练/? R1Ih50ۿ[h~ TcO$lcOc0H:‘9sFL LLUf#xҌSg n+t]`"%4 KCP?63^3%7܅&v^ (v)P0X*7WU@SN'6   !wNL0NMC|w]d|$eWZz _{.h% uhX! F#]a aTL6"GGIa) /.r9K4%ق'{ !udV OŚN OA P]. oj}?U>h~G'8a0`11N DBD4d'SSt9SvC~X/i*Η߅Ew:?8p"©Qrr;j-wXC&Qf3 x3 DT3أLu{SsBL &3)Γp;-t {//AdOkH7أGtIa&1 Z >E_Po_ő|)yoV/ŞàSXyV]Ldž3|:|x=U2o VMC=2]#E^H8;)EV0j|@_EaAX~)NAHZ#l5 !n 7bc4ˉ$'Y-;&=%t,$ @= 7wkF욽NhQ2r9țZt邷:x=vZPz6Pvt}x8(IY lc;4зA%'cI*8z~LI;E}4' !Ȱk_z yp*5mYdf~icC> u=qregqKDUI9į2ѕ‘gX8B^=Z_ԅW;XSq@Q.q#?MF}_C1R5I=:Rwl,OL&Z+ TEئQ~5oimԣ YK]8E3UEH#"b7DUUB@Jh"n iV|=V R t~pfLNgPE6xԧ`*ST~4U%=5G]L5{N6]?}#_ޯq GZf@2;QaE[lZGu?j ڗ'+YƣSo(:̍j:b@qUn@SY-/ MxAfzjn1M3^O>m6-&94C$F9 M&QU!4!7itz/ pߢi,Y49)`z NJ>eG +Wo}𵩼vP?3sW:kBk<޲jwՕvXl9Vn_{!"2ןCW4"M2ur'F[z!$ԇMP6:~ veu[ZɃQ_> ͒:mLmX'iҪuaӬGىƼʹ:2_1d K܋=Oٲ뮯NkSA$gHMcg+=u8zLV"jEKժQܹ"b"RNGH?M0[Km=;k`Y#a*)EU.F#b4;|"˾WW+TReزW*Vŭ'4cԣ)BU~4I J@Va8c<7 d-zws/1~ӧ &E|u[8Šb/-x0BO؂'فn=©GX{~v F#8&py ܶGpGHBmc1)BG' 9) *y[0`s=qnF_Xb7 ^.n^=;7:mFnB Nۢؒ)-;#oG{ێ#Ժ]&BNZ>Kl00NӈΣE) IJRBbn،p:8kH\omO(#0hġL|!"֬tq#ͦydmsȓo|kt|3'"/^d8p EnWdg!#ś}$V u@tH=弎wK EDbＳ+_}77@M)[v`lj)M2(W<1AVViXVnↅS\9&+~L2.Yǐ1Լ]һMooKɃwޓ(2+B^TfL_|0I<=,ͷūȃ_Xwr#od>uKL4P].2R9s*m{"*ed[d ʉRbSqB>T)-[ 9H"""j.驤^F״ᯟ |D_d ;+ b2#1?:75ٓƤޢ|5̖09V?3kV:a R.ۭ^5mCyE}ld9<=o˻Gh(y6uwE@ ![ndDxLdnBjr"+ Hⅳ8E\փ"+́&ྡྷ_ >3/~|C~f8MHMJ/&/n~٥lńK0R&%k->.55n|K[uDQdyGUu铱{pz [02d^f_}U1PV՟207 3 Tp{HprU&,"Kۭi(F#Y,,M :" ب%jU=M74뮯λ3^mҊcE4 76g౏UKIJ8E)W0٪7P-R)as^"'yzIps]M8wfme?`s!ǹ\m]fFL|v>H]?ٓi"y g8}t?{6.AqML*L}L\cA]d{%Dwy<*\ų;{9_.Xv;5݆-PХY~m[[ BpS;ضjM㚐gb `$K2o.FpU`Ԩ jͤ[<Js;"f]O.nd v6Ɏw"3?y {} F|AV/*_kBB@=c=QMDf׆%'ok *yu\:$"ౘPTavEd˱rkԨs&(R{#KBГ( KuHp xY_C{ _ 9pǵUb{{V (c f"Ehˑݡ=~Ms< gO}U 0v%hҪMZwKe֌T H($zL6B ̯s`2$3԰ybS\N8ǩ+%91zsפi$]"\%=w !)|e#6W>gBHn)^&(9Bn،4N`5\k\gShxCѬvo>&z>kr H UIDAT&E1`0e|(55Tlal8zk{6wfFHgH,P>+Am@?j]v?A^5 OaL]ov+q{q:O(>A|^|x..F`/e^ G?1;宫V{XXc؅:f Wf3 (C98zW^>ϲw'aL>_1x?wAW*y@v#vx̛#UB~K\r׶`.MsB "%+M#JkUuoq""6p$Q._:Ϯ EP {vv~xW1(#tvȱ; ioٚ롏x蹀B:`?~Wk{~ϣ/^Qsu~5uf`ō[Ҩe*TO_}a?rr逩+hҪJ%#qwCQ#[u"tY4]#5"GPQfYKג~g[%(!O (!O (!O (!O (!O (!O (!O DIg$(IENDB`move=1000;blend=1000;3H5QMM M;S ?'֤'Z'ZMjZZjTQ֫O'GUZԟԟZREj֪5'ԚԟL&LBa@ff3?4 ,B fUUUTUUUTUUPUI$I$$UUURH$IUTI$ ""I$UUUUI""""$IUUUUU$DDDI$"**UUUUU$UUUUUUTBI"""$""UUUI$I$""I$$$*"$I"""O ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???nn$??I?w*?w*???@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBiological unit:PNG  IHDRc IDATxwXTG?tc. *H"*ذލ%hh,M1ƨQc5v5{w;?fw]%y3gfΜQ+ +Xa1cŰJbʒ{/r7^t_>ʢqm{ |bDvutן%|jTY*>O"Q׿?n#]ȥSGy+|Ar+N !*`co˵}gѹO<ͦDPPBP(zg.CNJr"Om+?@2yj"?Yw-s>q_[Oש1(JP*2 \4@`^ q*;g{lBPGq]ڛT[WY|cF Cxp*Ӵz0سǜsck"P ԙY)`"15uG5!@?޽ZuM:'9{w}`FJB\^ j_[;tQT4 o?Rm Xs$|FLnZ_yJ4Bpeܼxz{iy`3 x:|̳լWA@rhN|8}ps@ű'm2wH~DfJ:7\|GltX8UwG8wK  49BM1L(k5!+-"68sѹCPԻ.L3+TF-{+Y/}t(k⤥EJܷ9MIDW |#/=cGxJ% c;vUz f2s ^\vsm@X%09Ʋ--Of?͍H#i1d h AUG4Nkh4@ h ?|L/J28k9-@C\ۏ2+R5.;{;vȳGbpBI>gF5hrҨߧjmg?ܹ3M6Sۤ=oI5x3[!M /&R,)K;N`x!O'4Օ//, 5uTʥof?H ɫ"FHi2#Fms8x} 6*phfWq`ZJa $^cˑiDzr:e*TA#:~YNhn-ΫHKeߦ7O41 )f!TVО\\j@PyBAVTQ{IQ7㋔zKSoкy11s?8 +Gϭqh#zMbsjb "A9sFzJ\vMgODlDI]Elbb*@tX^ow[Ő J"I6XfdQP@v5Bo 5:D^\DG#ʔuÆ @9%bubm SAC*̣ZZb *Gm#[*Fƽ{yer"Mk]hE@5^GH7 i(4|&ɠGϞgxzzpuWF~΃[W{ u8Ջgrw,bD ohכ,`^2;;P4C>-@꫷w-᝿ =uHmsyLʡ5My`ѢEO 8;iq6Oю] pN(HD \gmޅ,󫭃SN!ݶ޺f~0ihȥ0D%֥CLM'-)^Hbz=`>r 2vҟt @hFa[8QRm~2(>u ޻#ػw/;)yZ.~_A7ee5| zZ#8E*x9 ce#;%[ھÐIĦ3fU9|;ARo\6NYh n#P񆕍;W!ްmH s"5ӀW3>tr7J%\wP0d0X15 3{S3& 棌=;9(?mo;E9ww^omj%MBR4;w. [+=jO?yr>J.?PPA\+J V=ܧ Q%#ڒ ?~'!?(U'v&Ƽh:HU+vNI覹x#y4rը~֞+ 8#P',&kk} (`p~R {gVJO]'?SdJGVt0UNe7mk: O U2]ۼ|dKET3.ۻ{޹نԸamٺf Of!غ|CBY`l4rȗfbv$ y|+9iրjH5!+ƻago~ 7D _pw3[ ! WD`R21 hb!@Ăb-L'  v N?XrQ 698-.c *kE |]3Ddzu @TEĵ}R4QuĀ %=mer_ۤ5Fv]cDH"c`~ mD8 ^H{ ƁHq0ı-{]2Zɺos:;:}d䛐彪uoy ` rfYjTdf*CJ_/=w\~}P#=ioq3',}> 4 [wUÇMYg)9|o^ݏsmd4_pH {ӧ/&"j7! ͪF %( n.1&>O|%\'ɯ9~]ߢ+Oy׬kգ阞(TdrmK h@L*R5>|2.9Je±'kѨ4dgAVZo`،<;[:c몯7}tvI8( [CZ[ʍ݇r9|"y|Wũ#7}ݑ<]r+M6JllHӇ?ȣH| F,yJ/K.Fݼ377H(N X]=Y*ԙY2֔ЮM@|075F/sN{<^pmo^=±yVl6RHUǟNOhSD N`=n{'~zM;Ҫ@4-HFjѝdޛ K,>>N9~d+O&I `]Pm.7XK$+mƒw2jBA8i/ 7N53Oaa9 E}jV{(bOF)w_įq-=iT*9 IHs#m}>p:"@v2Eqq3j3a =z`ҥ4UFe8fH"2->a98rae Il,CTT7Fe/A?~x ' HƆVsFp0gψs~)-'Qy;F18/<ƣN54*4g옱8o߮o7kb88:sh:Z"y][ij:plQoPsf?@Jk).I .hAEGJV22K .V* xD) Oy`q bm13b\cwM'uͦv kȿ onͩfƏ ~st||į..b1 ڏV6c)"nL{}(f-ghPidpƢ~"dSHۜa.DVZ(Z21TD $v2hȤWQҧ(]NRVRF4oOUkQQ"}d@|=O B3SSt#{¨/#i+"pprMb"6uQ3ۖᄼn*iK*!C|ۈk֬Ǯ ߤࢭߎS/goWL'7;'6,ܝ,+@ATM䖣P(heW U&+^o JT)_|rw6L蜡X,Uؿe5Cuڋ\E X߹s' Q #t50aO`S4*5YY2UhTjP(Bo 76ne* 4j޿Jt>yH!I; dccc'H&ZN;v,oQ7nI&\|1cgq|kkAr=eHк n%+t=q^~ܹz~J?Ѥ"ȀA@PPIC`#Mⵡĉ4X}rEU{k _Xr.107ham@ j5Sfd7D˚=VA !@i.3t# !Ш5defDz <|;rڻ q-XrQXa֜F OTSט4+al8>zE1Ĭ˫so(TϟgtrJJJ m-!U$ @o>4HsЦFdfA~\AF-ۂBD\ tBIϓ'+3۸_RviMB*δ5R C~'>BPQePgIFy 1NZH]@YWWS?wo9 &$QC[P*?g!6>4<h՝f\HO}˫OHMNBV\UD:{PY)?KdƥNşs^1#1 ;?tOSKDȕ:t ^#5B#%+Fpi JT)#.(^? 7ppS*P)ŮԶQe /?yAVfrFq{`"}-Q=8{1`A&J`ݘ>+L\*AJU έG &6OJC$oqӱ?[V.qHe喵sϕr4:&$u~0p5(ZTk1^ykfEjp-o_aR=!AD``Q]KIDATQF)EhKLnf׸CeYb+ϠɋX5?l\;'QoeAΠEmm1 b]t)/_R)R &FoV͊c!Fm\qd0 h:9pxEN2I7)'..P*x H*QHRlvpmۆ)#bscj̩SdT,:~8a8c R B2ᶶ"02Gn7^+9 p!ܿ͠m|H* xH`rۥT/WH>f7=OL''KSn. =v3{s8̅ F u2S3HOJ!$qDGƎvO2.,llm_^`{;/B*SnH7xOP%X ca`<< @iBAHq|x_>\yyVQWCwE[̵qt˵MJ`p~J[;up/9n`t<[߿?G*b2̧p97 y.C& a<_X 99k_i.hڴV{ervTdymܘ0٦S=Ͽ/ *xU圿jq[&I3<̥Τ5>6h4z R:R!ti.>)<G ڿ>ESCV׮8 88OFߑiwШ8V&F:RB ;{{R220\o"YޞEH]r9Ν{Fۧt:'z0O Xfkm -5ŋخo4\ eۺ{=w#sqN#(U I U!58Q#Eb+cKNhx]~ϟs)C5>=/+5S\4JG)P?IPzܴ+U.%K2ٙΆ@P(u$Hi7[Z;v0N2DJ4.Ѧ}Q(CgsZK=Rf"x.rf^k@!4a ߺӍHzsi;sL <t}FyVH48AUnZ r-Y^'T8ݱ# 5:!Rg3XP4%w\b5p-B|K)t3UڠRunسgRSY1=?담4P*B*#! 9jݣT/T8 1H䪲TvEd܅ 4n,_Ȉ!EzCUGdtkEF?[dE^T;}oYvi惾#-mJ, QXpo>. #ݸ!.6KPJѡFC"RU vwzϜ2cuV3H)O4jvN3XDj5}2GDgTtp̪L\oJcg=Қw;={,&4E݁٘b524 I[Hɏ?&N"S 2>Q:.q2iwu xRuyPӗ`oX }eM70P78KkZ# C}Pt[qF=66y5?^bH5 龺i~⸭Q9C=zh#/ӟ_8X;@B:a}(ߏ(XHQȽb?ҔX{^^ԊgZU%dZ]MrB+Dvlf޿iJqb: ¯q-SST 1JmǷQmlv61F:8e+ʾ5EǼyG11< 囵kypOٷiYc)[囲ɘ 8/017͚5cqmj۷ <ȠK' H%OǕ9+)Ӈ~.>(.8OΝ;ΖdK{M+W$V^6Ow>v/OD\+>ѽ[Tr805dնR2mlH:eGnI=ދ`jZ5-j Jw<8{zrӅh?uKhT*+22pwDrrFkte{q#O :U|C240"#%z@X4ib_+E$b_@Ѿ@l)P@Pu V"F=B4W4@|{Ȉ_o Fdn}MhW\Cdx~ZllY30P1CcuӖ |qݑAK.h&h&mEEp1DwV_Z] 㶩#a4_w5zu"mo1+lc{̙ZBx}D#ڋ;wlAfB} CQ##!k!4q # ۋ&ȗ 2"㜖xL"1QDiQV=NFS-|V*$!yFwqBAȑ#EhLsQ#4Z,#QÇsY] v,!*U!CEhRDƷaHm9# {%[ K&i ;d uj`e':r::_IjUj'nҫF>rmq ߥ;TcVCڏ9xQhC飏xHiOߢ3Xk<5T':4CېzAe}3һ X˝k2?l\{RP_qY.n?N{e G%;T^g"7N\)dgPۏq@FߖfJuٰa<@b'1[2!u9)X뉉Aq ?^ 4jnOOs8=#Le̮-9nELE:y .EPꥹ$HU'$1 ŅUj|\7JX 'R)]9|_<{KqBAЮڒՕDުTz)>@FyIݟ Й @*R7~4 ¨RՋJAW.-{%2DŽ 0V=T7t T>yE4lE ^;:qvO!S8G2o9`ѸGFՋ"nh1-Z(onqSҗ^ӎ$m}I(!WÇi?`hT\*:syI WL&1pLe*ox3)̲0 ##J#dK`*$i>[;\\ 7ڍT:v bE(V R.\Ŋ?ٵ+O=`_IΔLə%GzEװhWâqq-mٺת5)Vݬc/.PiҒ^bcɁ|H2{BlsHM~CZ[o)e}DǽCTHllHz "n2yn{/Pm=i84pYɉ4^ U(W41-TQ-: Ur4*cW]FXkR)~u'0\\xIU=Xt2ILz`0q_pi!jo&X2sd1oPR*r>"ewSS!Fmֱ)K~_7s3jP.LAu;EmÅ7ٱHG9J,R` yD[y綵r)Vi ;+G!)2}i -ȕg)If4 2ӨGgglmCV!LVVGlڹ?sV|j@Up_bXFړ_H<{ݹy4io)V '|0y>q_DQ7w߻ɍK]R*+LgeQ G u*9y.:RF*W!h4TCn/gMYte2xEDa^gç @3[Ϙ1\}:h˵ Ő/]CT_ö%t/0G۶NJXV«z>JZ6ngFX$uڈFmDHTc&-xU3W޷Xq iI ![A+Es_b[rz8D+]SCԊ6NDW덎Ke]aSEHton:G]*~α-Dd֢Ax}}BwUWV 2I+5Dl) 7$g4C7igr{Cn[OKtOQlBdƄ7vc{ MpȞu\-TInF_;~q,=c{rr+9) RTUI3XZûhܡcDɵ]"(3Lqp{˹JeѢ0D>]uV1צf~´--^CDP/ f.-{\ in>E\GĶ,&"vlmknαi6&lmTVVn RvtkqH0&a;{+1 ѽ[5r65@"Bѧ _P$k1jk,jFqv:ߠH45NP\%HKM%zwtOVJؼ26PLE /œ9Q[ R\}Q鮮i\WҢd[xgJWYF:}}!:dlu2I!j\ ։o[)]CD5!Q|XkG&P5F u@;>3A P{a3+?a i.z.jFq+z&q9JuJ2|O~D>2| +@zO.zŚT"bԜU.NNB#cm^D6ǽb%ˈbʊʊ-׍JyXxt4ij@<C-6G4y/>jf#n0[ReunˋX tђ4on(b{~crՉ57Jџg (j;RTY=V3[d4W[ӻcXƋ/Q~8Q9xV үt{+ZF*nE+ke*sn?L0WܶߘC~WiԮnjQGT.+xcs%~|*Մ{zy(v3VX2ѨU<4OXl۲ +Xa1cŰJmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QB1!"&" CC@?!? G??!!?ȐH?!?! HI#OCH$?Hv@Q ?'֤'Z'ZMjZZjTQ֫O'GUZԟԟZREj֪5'ԚԟL&LBa@ff3?jOI?IVDI֤Z֤֟iZGIQUV''֤ԟQDZjgI&' "Bh,B fUUUTUUUTUUPUI$I$$UUURH$IUTI$ ""I$UUUUI""""$IUUUUU$DDDI$"**UUUUU$UUUUUUTBI"""$""UUUI$I$""I$$$*"$I"""OUUURIUUURJUUAU$I$DDDIUUUI""$I%URI$($IUUUU$I%UUUUT$HIUUUUTUUUUUUURJ! $HUUU$I$H$""""$I$?~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???$??B`;2@?R?R?p??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor residuesOPNG  IHDRc IDATxw|훰MB H tTPPUXz*x * ҥK@ $n}MBHz<)3s+&@󟾀++乂& yɸB+h2 +乂& yɸB+h2 +乂& yɸB+h2 +乂& y/ 9sG}\v2Zta0 ..4ʵ\q#= \u :ы}[u]!)+nGAAop3f3fXzoIBJ_rW_?2)-#=ᄩ /<w?&j=GQQo;7Lh3p1xKxg))9rs2vC)]!C.ȧ03gZ\}!}u̘?=ӿJNw7vy.Ã>s$%qddSm 6?@P;W̝2 IG$I"*Gt^j̙ZM+V0穧p;Ogܗe AHH҂?P\NiY Ξ'\I8ӧm?EiӞAաhhgo_;;leWq:qJpm^N\QvvqDIE;sMjo7f FZNgE<zӧ/e%fbc-5d F3>Z4-?Wg;GAHH|s[eYٻwQsC>NBvKt-ZL&,fRSk!0NunP>|:.0HI>( 6I})Q EQjuDPPz]h%y6!RSoT_] ȲYqUw4 I`2q~RSw5;>/\!C9ٹZ۸Gx\~cNeΜqu;E "1q.7u2rFJJ عkw{E/w]hgDZK)($5{}ʔtl,Kξ}2p0^{m~NgFH0' ˎ$j ?߾oXx~OFZw<֭z=ĉ7Z'6vC8Iٽ6{ع{k>$ i R5Oxx?z#G`0gOХˠ]E}UGGFԅofm64V!5M%KFTAL& G$@PP8͚!IY(_G^:u.?|SNz!}g^kTUٷo%<'nj)yfs-ZO{jKt[½9ǏOf1LK2lq\Jzz(h4z6o^M~#e Yk^jZ3YY/q;E !<\oUKK1}$ZfZ4n9yF3_~|]AbW l[TW7.`_ZV^OZG=SQhW|}7YA"Z 9h((x]%՝.u׍2"`ǎ}deCpppX-z4_'WsA4S jCvel- ++*ΙxJZW: NA}QVvv1qFp>NW .S햔f^lң ARVfFitսM&OIxnٲ' _ͶȲYe[Μ9X\g<tR7y.W4Z1jxNG˖} ZO4r4<q8j&3xᅪ3Ϥ'7(=5^>cOHIa]Ghnߌol\EDDGزe1s`ΜUk׮3Z턇Ga25no CY^E~dV}~{Zngʔ,[Vx2n<&zZF|NdI6&99]\Jt!"G}ȲpXԑݥ4NCFbw20f\~e!jv4o>|yBiOY^sjeFp×l85Yj u_#c2YpAÖ-o8Hرu n}+CAAN:E@5T-NnUظqa;0=~&_^+5jo!9a^OHH~9Ac2!bϲ72wAxGk2yt:ce.\(&>^&;{?'QTtdgm&<6ɀ1TkA R8{H,:=ݾǿAڶ]xw_̙iStT}Nz+V %>xAk9!!W1~&/ԶޚDk;٭]ޏUȹs"99m$GIM[;GtgvjTg*f=f$dC\]DFw؞ h c^3X8I*#6v`6:tX@TFMa2% Cz=p',ZҼҚ G}{!=6- 88glSgoM"Ohh nkeRq8vLuUHMRWWQv8rn*Ѽ-mj #ˉt%ǎU}w<đ#X8[%H֭ӳNޯ=sQhA<9}]ҒE9xm6 NrrVp{$'뽓o,`ժ%~ !KG6IڊlYWZAƠcŴn]KQDt:7:]몼j*(^@ )Ah(ŋKP3f<N %e.fU aU9бc 7B;aac NLQQӱXY S=ӧd۶$(0~ύ~nۏG|k2'=cZnŊ8~/eZI3Ngd{,Ӧ(~iTH9޲͹sPЙ_W)5Y9?ɀѣ׃u8{v+ZVVݙ+{>Ad|-^+n?LI@C糒8&r[\ysC',HR%%?~?pc]pp~r6l`̛ >_ 7ޘϪU5=|;"kmI3,/˲D 0v!I^~7}-8׊[LG ">_ <ڵ{Jyώ[/6&l7.ctxJڛ暪 mq|lC3Y8=CrsDD89; ZΝ͈$ϖňE=| ~vK(GFʖp|TrG~OZ/|g}gQZ[o9Qt7`ipۢDak4 R EQVvE:u>_ ƀW`(\W y}֭`0rUwТE+p~I/⋢WIN =+#F !!45N$!z};?`'%v{v @`W~q~b(49n^Yo?\]ƤI$Er̥<Ȳnwnwv;\fsHNVGTԵDDx()لպٳ_N~rÇc2)99Tȓ8AkDF*:u^޽ow{UL߾U/^%<܈$mR`В~ӧյC|h$C.ؿAC^gDGOD|El\5xN,Ȩ,$IBrS7z (++F۪vajna{YS7Vq-wu^ƪ떼4o޷ֶRRnA=9~a2y'Ur>uf7o9נ ^h64qϞ'\\NNQQ Ɇ v֭EG|e:/ FGlި Nn9rEFLA W8[,:PEbݺ;.NzF~EQU.өȲFNC1"Ӗ`\ N5ѣ0v7QQp8V)# I֎$!ՙ}Р'-7W&:uݷIy55ӸcG=_(zZ6YqPx.O/ysլ}|(x<8x)u{_պ}(:tuᇽ9n܏H,KHRt# PGNz5Cao_&))ɼ y~HV21fsR0|> O0y|>UI>],  JJ8|x 5/`?6md aޟ\LVo:9-EAQ$'ѬY;v:c/0x:DуW mH'_&! Eȑ8pFH7Irsh t6{6gpeAHIDZv*'fo(-[ϰx[t:Q_qLH. #FhXlӧo8_UÎg؍v}>"-רG5rjxQt#~$ :w~͛+ڷY.#:z/Az>D]@7)+>A @Nj5:dd(L#V- QtѻwEf APHMx۩ӓ bjcG^͚ͤ8Nv+fĈΚSYScSK 6),){6r7sݟKٺaZ9EmG1nVVgnxQ4bŽbbر0djdه$y()q!In22s~憠())7(^ҟdeͬh/>Y@$j7 _Ů](b<9YGBX>[vv[ƀ h1t">~!П̩S$r]yN֬ ))8~_utwiӇ/ 7e6 g q-PT? $$aǎOV9ӱ-$%`hW>gJK ),ٶ۩S?E$;[!!CeondCnn &S3@Fľ}KEe)c+Ҳ-dΞ`۶/ٰ^IΝu^kHH/@T%XxxWzIq5i((%b>X,;)dzӆ`4'~#-n;`V7ߟ;+i+U3:ٳWs+dg!&&Y!I^<l }biźu7s_ӵk7`4-~'YfJJ޽1c^4$[1j4:~'^7w:hQÚph|h HJo׈N.xNn}n݆c3b,+'yo3`fBzwRҭ1j4E9CJ-Y1(YSZw9Gj/l5$_hfjTն塇$66gOugpl.l hHJܹ;q| ZFRR?JK/RVvյzRRsՃxa̘ 99GXFy)D?,zvs={wsX9(Dvc8{vGѓ:GJ8(o_d߾Xf7f޾CBc6A1pbҲecq8W8ŀAm; #q8.{ wJh"ڀ$R$~d+) k٬geOd eƌ,^ܳʹ-n'6v6K]*vCH󔖾Xc;vWĹsuK5aȐwp+>ÇUlJDF&2e;,[pme1B曇*ggʬ}=4gP_UI־0lg7kv"tURbb!IenX#h4GKBDD)<8[5׼Uˈ{Uu"vEqYQq\uI"88)-[> +kKc/^j_3SL4s5;p)X,0uL:NZTٳIL91˕ԖfL(PPP)M@>}fc0e#AAaM"ΠA j=;!I"߮ߋs燉oW휣!a4]rD5 3so͕Pyر?rPVMVַ(BϞ墢&Yp:QVVs0&֯cy(*ex<> ?,a!Iek7ӧTi'#c mgʔ,[6{(%t2'O> < U[wR{i b;h4@@a!M&OrJJRZ1d fkt֜W %ZyZMuۏX$ΚQDYY!z}3z Fc0~O>x IDAT0~QtpiXB׮prrt֜ bĈ7(>kXbj&:v(m]Ȳšۻpa7͛ל6,l.QF.Cȓ<P8"н{դV{-_|1Z}P23шl_dDE9nZŤI9qs#ޫ& U ,4Wٰ ZwIaW'~'SR">>zplt<G5aC8Fe|UaGG1CX2{^.Ci1G>E.oV_= 2`|+/^õ1MSjyNks=.W3$bű}>b`xJ((01hHoǛ4ϯ #ZF{IX:*EAeZk90+SEZ>r\Eh ERPW xpm:.u:4d`z"ʕTN B h W F`>"-,غU kXzuիq)`h>YRRmt:3N ڴI`(,<΍7F%6V޽KpdL_BDB%L߾W˥?Ɔ jJlPHm h9zt-Wl6d6c00zަZ7BבU~g Vk99:cj3$w:L*xCoO\p` xxT< nI`9} 2n=l֯:[LТ|no8|9m|>)wDTTs,IEHoCNj|0v:YY[7Νޓш'n][O/A=k|`dعztA"jde7( />:^NG]F#`Yɹߟ$;'NԾF:P7ǫp<͛ڴjm?AuVWps駧ؽ'۷GGga^ERXx?u`;q#E3ԩhn ѣ0>8O?](z#E4M\(DQ2DݵwUMޢ /2;!!}ة gVͥ~*ZƎD}DG V>}ؽgڴ1v0a>W!3RG՚9}Z}Emf>L f:Tq/ 7oK;ۏn/Nb|_`$3=@HEEvI5^\.C]Ȳ=ͅGR(";&5x<.譐g=\uUQQ.\ IZ 3+W*0`@Ȗ-1uӘL&6oΠ0I4~,Ml4q.,Wfj8yp5CH^--Y,zرͱWU;kSӬY*y5Ҍ1vpLAXvĭ "^YO0z[u֭<|_̥rq8KE/^o }kQvh4&߷wŊNڶEQ8|xYY+س^*ramIU 4 1O\vBAU ̪UU%q۷u= pP9L%? hINg@5T}~)\0|r)؎_GhQu55KzwΜ9 (= #F@|>CŋU=N4Nc}l0 ު#K))q8˳X59۠WIt*޻[oΊu鳐 AZ$ մwn>V-,WSƲui2,hdŊ3NtF NU^:^fhy |awFcذaX9m&.n(xfs(>NNg74nv" ƍTgWUM0OsdfV5Gt)+OZ}h4Hvv2c'.S6<' bkh_BX:OT;2Y8=73s~sZ<^ ^{9odMҥj]LN;|rjOX^]up <5;X>-ș3v4IJY; FLBN I( ofJI﷣әU$ɍRwK8*k7sHqh5AF5XfsӧiG|,\xGmX, ll?}$y+B}m`6CQ\(@yԻ?<;@6rU3>}ӧO$H+lOppW}G^wTx '~(C(0G*{{ŃݾkJ"7ΪU;JP=7lh~}ފ -mͬB <.ll YY;()9NNN"$ɇ(YWv]Ro}9!ٰ8zI H I^)=ލ,;^g;]t6PlF hz7ٳ2ڢ2X 8)v1Sض-Ppa0EkWe^ bri(M3<5#N:#Ȳ{=KT2xGIIѮAc(Z/r@^Q<.ŵN0 Qcpa)9:w~z}zS1*V|EDGWۼl}aT)4t$Dlq,`347CkF~/p=]i2 'SSV$%^uٕ* yTV[*Hdg̙((pPZqh,\8w)D^dgd3g&UfuLDUh֬-wܡflP'7))+ t:s Nx Y$yHH2:1#(NYvMz<$U.'&fzR,C4CDŎaaMP`\S %Zmt@EE43ʲ׻ 3wdfmGll>5#%,A扆f|=Lӧq D1mNe)@7aaBWu;'.jEnHR]Vw,\EQ?WeW=|SCcE/=llm*|ɧCttk~u-6[ݻ6 11,BzsCH6mn@aUo+LC;=z̢|+ʐ7G1!z=99g9sk~Id(FI9zCffp,-]t:ӧȀG7{#FF51LȲrbYMrZ:8vl(&o~ɯ嗗X\.;_WFuB13s#-[㏿ϧ0h]lڴfͮo tӣL\E0Jq YYjc\U (JT x)(XBqbj a:th_ ˙3'LcǎL^]j%~wqgPTn#ܒϯhPZg?:X9x ( =ƒ%wк5,[Vhx<[7jBŋ'E/}WZ )i,6aѫh}v*Mߠ3!aT239%N$IlzhLm4v v]Y((ȡ O֊w~;/Ҿ@ħ~<&Mh?H||N]јLRSF>$%=KT@Ś71 yh4dwIBhf]NUrr?:yZ$&^GTDLtAQHJϰajf?Y7>.W)%% ѦM {h h4!@muorȼ s8dY"(HAE$ɏif+EE\ >\UC}mt828rY|lǣN]ҥe,=z/w_uƅڪ0"+k}T:A9ohхO>{[XptN+~U$Űa( ͛'2mHF~9sܛ(@@ E$74;v,#lڴҡCwƍۋp8\e(7yW@(Ď+$V $Drb9D"9|Zxرc:~ 8W!`2AqV6Io{݂^㣏l(zKRf0Q2q,_%=}W`$^d„G#Vnguhћ³fgҤu|m_~83_$>$ӧw`=z^oQQ bժwԝ9:ww-F~dʔ2Ҁ((ŽjFtt͚H~~諈΋9s8͛ٻm,SR_fVnrHZ}>ݘGl\CE=O:Uv#1A۷O+йN]_~bb :J^ŪU Q(dg_D*ug:Nέ&e˖-tfl6goh%JKiݺɉ 4w%hDEEIK{o|x7kFiB:YEEl:g=ƍZvTL'M:l8{ΐְccERR>[[M.rJ2D]ޱtѨc̘^E3עV,H-C&`(ҥyS֭XipbJt 4Zz3닟*a()Kb usCT"J9j QWS11-;EGdzJJ2(,FVurG6.~-ٿ#ɫH QС5:.< /͍ t8,oضc_WW^2n #ـFSXUIQ5#> Qzƌ\Vsr~tL!gϊ"j+XH2xQ\zBJB-T@"d0𠰐1 /ة̛W_p(.2i޼ XdZpҩ/k5`Ϟ voZOz-7nV D_׭oT* 8Dڶ";fԹCuT|پΝ#RYZIAm(Gi2Ao>99iH:pNv.`sBBq-5qu֧igٲź3MmJJW66[Ls37o^S8~t^V+a_]*b2=kSVv{04_mg'ET*鮯*<^ٕ˵pskܺUЮ!,U7sr׏S7#f~e7.3MJ`,F=:u[z5+ku5DÆ?eeG߾(/O r**.QQ+?K5xL!_`2Ը{phâ)-ͷ+_|ԽFof˶6ZDoys]A&s'7'O "Pȱbb>A"HK;lMaAO2jF˓OT**JP()G?hHQalyT7߸u+B ѯ3cFÕSi߾[eEz-uJT4ןĬղtKOctؙhxd|"R&LXѤ% @?siXh͚-7n|!,,Z[r'MZ%Z] L% k٥FksU‚_!Xaarw DQQ1%KV<DjsMĉ!+ٱC,剴e?$x,\|ZȔ)Kۏի6 5f FÛ'^{20&,'/&׭zP*j`q۶~j}r?4x_?$ *UsM[ݙ2Murrd\VDw'>BΤ('w5ݛx 92ypVxN@x㍷Mv6rW!.nV G[~֖E' vm߃?~9<T/GO>[\_c ;VOZ=>94Y2?aFKx ̛&۷IHp~tY$."??n9Lơ§%x"3\R1 4W>n83<.}ЁDžӸDžӸDžӸDžӸDžӸDžӸDžӸDžӸDžӸDžӸDžӸDžӸDžӸDž/_:AIENDB`move=1000;blend=1000;3H5Q@M M;S ?'֤'Z'ZMjZZjTQ֫O'GUZԟԟZREj֪5'ԚԟL&LBa@ff3?4  @%3Τѐ!p)P$$D5 >=ahJ2OiJ4RQ$YBeYcG `DQA}g}VX5B ,ڦ\IH ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QB1/"&"v@Q ?'֤'Z'ZMjZZjTQ֫O'GUZԟԟZREj֪5'ԚԟL&LBa@ff3?jOI?IVDI֤Z֤֟iZGIQUV''֤ԟQDZjgI&' "Bh,B fUUUTUUUTUUPUI$I$$UUURH$IUTI$ ""I$UUUUI""""$IUUUUU$DDDI$"**UUUUU$UUUUUUTBI"""$""UUUI$I$""I$$$*"$I"""OUUURIUUURJUUAU$I$DDDIUUUI""$I%URI$($IUUUU$I%UUUUT$HIUUUUTUUUUUUURJ! $HUUU$I$H$""""$I$?~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???YQ$=?-3@ÿB@?@/?@/?@/??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xBfactor surfacecPNG  IHDRc IDATxidy;Z{խoLOwOFp8"CRK(Ҋ-EmѤ & Vl6b$ EQ∐"6MJξtv[멳'4Fb {DR֭sy/g8}@~@$ }-eYs{y[g3|?!M3xBU$4= 89y~Xy(VDQƓOg<ܯn Fgtv$v[EbY]a0e(&snM14E#*7W~~n ZuONqc IYCȲa46(AprR:yj ;gboy?'~~~ L"?kke(yOWx? MCLI~VkZO!*h0ݤ m VWudFETUgk#^4mʲs9÷wL|S\pr|xI(JN @%he]$]TuQTɲ 81UU8Go_?4aPwN~?eoS?E "fW]/wEsKL& ?EYdYLb<,<0z}!I (u"CcggѨN Jgko_g! M^xA M,-fo?_(:axz9(˿yc~|=''?@LENOd?;>oq!ea DQFUM\F,! -<=GyvEsl.lv,koYϟk|[oQ nD\wD7 >7I$IxQQUӬqfdiVܼYC-#LNsVEwHðHU]X]5?j9÷<"2 8)e8 GG Ô(rKX*;;4]=La4H,+(z}$16`lY]cI4u<ɲw !$m(:4;;40e9*I I QTCl\\$MGI0կZ(N(diɢ^o%F_ny{އiZZuҴ99I$w1::?O0EGe /83J'C|Ui 4(*1z\" 7y#eN֑ 0(ˊ<뺸! ²zhAY&Ee) 3(K*qi6Z6I#-ΝEPUI##\۶$' _f?(Jt:=RVSq\G t-*i4[jȲdY3hj U(ȲGEhTUNBelNeHYJH$#I\°D%`L4ZMgmd:p$ǶE(ʄKQd,kTZ$@$KQ XZ,+yL2 Ð,KCQ (y$W? LSCQT>٠( DDa,#M,0:TQU V'%a8@ &*zW]7tzL&T&^2y{?B~?MɳKgE S ,\{e)c2A(r4Ay Fn pwk"HX(K]IM(9A`3dfm26=ei4VHHSI%A$34 pJ9~FOŤiDR1VC$gk}\qzw+];_~va.q2s|<>eAq rueh|:{HR]&&eAի8Ǭ8ߊzɳyY<2a,khZA0LCs:m3;lo1 Ê "*գV[,cJ,CZsxY"UUI'as$)ؘc0<Οo1$qi Q,BBQ,$Iae1u, }׻~]_,U4F <*}^B4lNY֩zBEQU0yHF*L CTMt]& EcU5! @{x|2GG%1ޤ(TOU~DmP@lThZ ayJ Yei#{z;oooE%$.qq$ y@IWj $eY^~w$OGTT %@[.Ii%$>eyduf3g0Y]0jDoıKYEANE :,/[L% w8vi02d%FFBe' , BTIMNo`i7,  /tnQU$y1axdrxFVk8Ec* M䡇: )Y6'WW~W_' n hL1A`:M{/H&WezO6) {eAF@ H~-\%xFMEIC4`<i 9,Kgm&'T!^…iuTi6{(JF i44CmΟo2f(JQBNɲ(=&THt8nQѴDJ4 E $9(˒x䑏S߿B}۷$kxo?x߽>{v6ap (.<DQr;]>{B`*.@Ŷ;֭sT($z{ e<~ P¶P J2Cu<Yָ}ˬ\CT<%sܸO꣪MqLfϳ24 _!>am$I?,Kz;A_<2@_'=zml}TUAvcsA@U1Ue(Qj! >''{L&oELO . ~O!>DCZA3&Y6 mGE.(3Eqx`=.\X$JDu 4 $E152Ν{9y|!vV"eӔ4kyS|Hl%4+S9)lojjmc\wu"#dueZBxJU$8 =:W7h4[ZȲJW,QAJU)4U,\++s+TJ{lbYD$dY]zNgF0D( M31peɤiA$rty- ("tng;D@$4xJQ.*)U0S)eQ*E I$"RU"t: S|L{ڷIf+W*eʲlm)9iS9q,(ˀ ZRIu?uƱGN'seBw!OOGham\= HEL,4s]ͯ/]KPՔ pJYji DH$HBW(dDGnӛz+W 98P4RUG8Fxl w&xb}xCfey 5]|,FC,}0 ۷RU$IHר asIBl 1{{1%P)>޽(N_ NNm7<6Zqa"n1x\+Kys@UU1ƶll0 ޢm4zEр$q| ,/o#C&[i$im3CQeudeEn=8MzMZ$d'L+_Gw7@L<v])7\ag]}l%`89# $X9$#d*dYԈ"pCyHgɣ(߁ojH ـltz[oFBIye!=@hSLFcM3p{v 1C[% kk;lnnXCQ$Ƕ06\~0Dܧ*D"I<|L,/?@QUqttkqpaH99x|:ij"I>2x.s͛hq\۾H0Mɤ, v74˗ȲQHF\ڦ($g½{Q4DӺiEJDьV&A]'i:&C\&I2,TȲ1wYvM CuC Ķm~'xϿst:YYy, Q4.$I X,ؔZMŋ6QCȲP)K ,@ygf{Mwz6XYE%j("tY[ۥV[ 4MB xFUZ5.sZuCUUzt\LUL&o',/_XE 8c:s)]EaԨ*K]nߖX]=Ohh _hш4 8=NǷwv;a!y>Cd 7_Dy4Sxmik(yPCQU)PUM Apem$*%IJA耔 IDATm#I$()rzzwNFcY6>6գ, \T1UU I⒦lRl_+FpAU,K$Ї~QٹH{EX0O"eal' I.zJdYkD(4Q\a:̀)) y>۾$i$GN99b:=%\pFQ̷?-sqM-^&3!&L&9 1Km LSq| (|t4]! oi*E֣Ѩ!I z>Q4߲UIUe*a4E2E#Irdyħ«L&7%OMUTUFQևHo %bEQ$;rt:04|tܸ*CC-2emEJz"ⲷ'FNʵkM^z˜J Cv{Zm ,S4NUxޘ0%aqrrߟ$A0c:=k_NNޠ,3|tzDZjj1e P6UpR]*<%'I<(LO&qNM!Y$O#`%˅7!>[e.RciK Tv4ٙPR]ƍo_e9iSt>RR-SU*i-¾e zkzQ%U#I$ijxJz| y/r.m2;Ap%E`Ehq''wqxxUm j_;ǓO>@AAU|? gZmA0dYKȲ$ ZYxE#/! ,!Im2&IUUbX:EQY6Њb>$#d ߒ(t:&ͦ藍(k8)c$raY_|aG(HA^ELi6QUUy>^xc]0ʻ(NVF{DQ($Iceet:t:6JYf< mIɔ%8)a(`Y EtDx1܎jm[…%LNbrDQ@h6/""UUGs2Q$`iR2Ÿn( |/1ޤR"%M:Zt:;4+robW(FAjeԱ2,wQaA EPeFe(*DQtn )L$I# _wNZmz}$}JWUa+j-R4[kGBEQT$!MS<&Sx?FQ4(ƴZ8Cr,Kb2aud*Y6 nolniqr2ŲDo$W\K<%t`nr;1$" DADe$!IE2ztA{dJݽ,ۼX^y\w@ D4]Ji9eY?L }$ LwtyHR@QqN(˒'X^g8:?Fvm{7qcӣ>e*I2&IjD)*2>'>eowf+W: 1>E`yyi0<, 2fDe)  882X__@ 4mE@ӚvNGFIves X^~G7xQ4u<,Š]a>r$$EQU<G 2IѥZ^oc {{f{ G0p@098Θ4MxMM$0\=tLF`p0''!A>=e~èsp0/"dux<熱0ȲeyS[$UiD%i㌉",KlVWkKN,':U5׻U],K|HzߧVEחEQc:EW.-UY I&q|Lޡ~M[Bꀄ7hZMQ)Y'$Ʉ>=I ׯoIoG&3֢ OS2KQ4%"M}4@n!$I-tEȲy{mmdt:DEQTfSE{\S$feiI0~ E>wW)7EQD,%֮r|<Zauqh /2,/?`pLɉBfdY8'PAQjUM`!EAUUvwߍiGYʫ? ۧ<אeu.^ܬ5q8{"}ot$?/|C8QtHQTU@wI)TCu4)"B#66jV@d"Mfo.|Bʢ M[B <5,fx5 Y^"! Yo5d9D T5Q8<̘͎׉S<0$4m0/!:ioI&z,"|aee y/zsaZŶ;hZ QT+LٴZQ,QFnlnx a)׮j㢅q|pDl,[e~KtQtR!PP-^agI2g~W?ƷO9nsxx @Q*Ҵm_mMc,3Ͻk{dfS(QE7a<;1b'A _<28 88c.m-DIIY콪kr=8lmǣQ=@ {{v{~&/n/ u|i2ay4f=2EӜ0[Tm7xsˈ|>~: $hccJJn~:dw5x:qnoQohl1'I<D Gq Nv4Ma4-,(ceU-%*wYZ!]F@jfPΫ cᢪMJ$뫄;ax]3qUrtCl.&^σ&ED1urew(vʿoZb2(B a4S*д"&ō14rfhA XV8^v`Iںl&qt#)ʕ%2:[JMk#Z*)c LSx}:W09̩9q :\BjBaPn>g{J۔J$3ާX\䩧~=&IBl{ A !"qh\@QJHRJfV6|2? t=Ν]|RI!$)=BŇ6 ,kHuڳ1U<.++F,F3dY² HJDG~nw q]J/!\s3S CϛQ(TYXX Mдo}-B~lb{{#gfOESQ&' RXX#~rBi1Y4LS.oQ*m'Xyv Hv$EB0L9]};4дimt}ȔY.(m c8O[A!@U#M~>G?}jK({'\2Lv{ȎQPt)ȲBE$tFPJèP*ըTj*q17Y^4n0q] IN4]N=tLբV讷n.;;ѴJ8.ie!3-a~|MX1t_'4~971{{cş^Z-??|^DJ u2 }|TI(-ߟ1FeΟrıODnw|~AHq(J43`>?0^BUh"ڡP I:bDO"9 cRibqE)/=r.8.e{}Fi4U$\2jdu pﰱ^j% hr?rhZbqN\cqqZɋ/߷e,|-NN8Süh(''{8hdbSz} b2C5a賾tj 2(/{~rg=;,.f+[L&?Oi^G566J(^ =d'C$IPX̅ZN -5TU\^# 8NLfF*Jk9a.FıikqQ$E"Klo?,7I A(( ^~pCL] IIc8o>Z՚p8䳟s3ݧZDhZ0S,Y[BFbQ'Hӌ?lw C7ogdw? !?ܹeVV pdrx4GȲL c" `YSv1)HR(DQky?s/SǸ}%$I΃|' }t}F&,Xk?}Q; x8 u}: A0FB4 I='+4IJ%3t(& b^gZ0ڬ1̦HYX^~mgxހ5GDU&gEf^t4?$~$B; 9F5zW-YUHm/}[n~{ QE^SUwqinð>L2xO׮!" 2V\nl7!ZNJyEńB4AZ-PW9>)j\Ԧ׋P c1wVw"?ŀA0ZZlHRbq (B8Q"1YCU?gSgM<Qw%I1Wq[z+kJiNIqxސB$i4:j~P?@KHԙ`0܀!s~٩3Mnx Ǚlzcc0:.tIM b3g*aR(,3?w0p<ӲF| _9yBBQ=ZU<\,$AdE&RuxބVkS,cΟʭ[{ܹsdAen+Le}bBrܗ[c/as-8b:}tG={QkPMRK@g~у ύѴ2;@CTUu y^dy4]ժܹnoE\ǫ 3wٸds~2:7o *Ve$U!!\<4DUT "A0ò8D(j2w jŲO}$I(:Rnɷ<={xvHם*Mvvvrx*E>FUfSO]ڵ]/(*k9|LKa?1 IDATtMVԆ\ܥ;KW(j%< de67NN,\[!{'BW+{{[(ʜR VVSݻKRƻn P*#I:\a<~$ y {J8X=4$~ʩ Q^@. (q$á(*V%2,Ѵvοvllv#)30mHZG1񮷭NcYaƚ{hlN TI?_GQ(,ǟ"Jf00X,K!O" T䅧DK^Gdsu6V u._J@]S_o1^Y|P(Y)G'NZ ZBQHS86L15hNGd5bA0!7 -)JЇ~gܽymBHRŢX8{sIƴZO?~^xx }>pą t"r Q(h67yߋUܼ8>fZN0#iT53arl/^e>(_ ڗ$ם 3ya4zE>C+9 dYC׫F=!kZ֘|] AQ6i4(1Ƕ9I!qs4E|!g4HQ:,a$)hAY]=`p8Ad1i3 ?ɷ{4˹Usє^ڻ |䗙&j77Bܸ(^qU(tX_M A}g” Ѭ|O_'~H"*c3L38;T*Ug{eY.Q0gl ˹Bq8ΈgӢe9~6-M%AU3GZ":qV3Y UݠTzh!R(,Q_TeC+j5'{dDbq  FNBS4\٘* Hд%̎sG*?5gm8M#Μyn"U':ƍ#>i;?d`<Ed6!fMk`q2Cee(p]QLS\ H\ ,..O!!Da|~tzmBe6)d}:.JBm;ԛ Rikb04 *Rt2#|MP0L6++KLX$.v/R(b=@b!' mE6A`4bHͶڬОoqAocl;#7U$f4I 8N66愡NLH {8<d9FuJˬ}%t x"BN =d0x ]!da.NZe2qnjF7$WCU}f:۞0i6?{$Y`Y'ıŋGؤZ]XTjql UU ZNSc2걺JѠZ18:^{Iq-dS=f'\ f]7e0s]#/YEYUF4A؉()i:ETD:J*f CaY~,rMz >:d^~:ժʍ_a8y}EQYYYʕ zߟcTD1l71&VV[V$hߥ^SVT\͝SzFCߏ8<ΆZ[F"|!U$I͙z4OrCc$ϛc,LglvY09$ƈB&#Ls,Tme#ߖ9Oq&X>ɮk2h.Q*#MGs6 Q]/iΰr'u5EEUp6b@FC.豳AZ5dYC "#>jNgec|>Of"BN1>$I@Ĵ 7t:2/<Ul`5TUuMΞ}舫W׹ySF׋4Z/9mefb~sAQnsFDc}.^a.^r.BBm[8%Ms FliZd3|AU Oa.Ak,,l1htںHwHӀ?'l@$IB3~\$P*Չcw0J?"%&Ci"Μ"MC~[׻eEQh =>a<>\f Z\[ƍ9!=FwUyTx!<@$. rrM,N89g&r`F$ITgkC| /s`iiǫcYr8ŏU$l6/N< loRpt$WF$29ƶ`JVܺEDQZ5wYZ ":*`YI o7\n`ۓ<r||HL(#ᣦrYh6Q9(y]DE,k=.[2 oy~{27 뗐$A?>0vlTO6#V[4ՖѴU*hq|| bS1kk!i}y{EXYY4*Q!Z;tm6F@Q M=F>g\0 dYag<5~?ׂe_%Il{x|L65,-P`6&"Ie5]#\wzǙ"mJ7\W8Evw5HQ4zd>[ıGhP(XveiǙ I++]1 'f{ll\|ddQ> {{o`=xq!7Ŷx2ahSKTϛg=! gٳ+jhZa$I I"FMQT*4eTUVk((EۨjJ2IjF1b~ʛbէպj7E _z8Vh^ޥO Å<2'<9YOo:=m43ϼm[ʯwa~߷s,gQoskxD$ :-6 AbA!IRXQT$UEݷEјR٠Zɷz[z9O7(_}d=8Asdz;A+9j;-(l/$V(3o@Ǚ0gew(8џ/2YGRiR,V{,)ek,-mQ*s4 A)$,tm0AFߣZI0Jz8΄bho>NTAӊln]DQbmJDQ@EXE2~IlWrF4M8'd3 1snJHʀ,Ngw(_\cY.3M4J6fV$dJ}4e>S,$Iʽ{X[[Ro?h|O~3L'Tgh(mxdeʣ붿xp9s})L?-ܹ)y]ryBf]ӹY[s7 kk*wrGQ ln79f>_Ʋ&LLVBQrgi)>")Q2jXXa,cYGfvw.FV ~0}~˚#)hyyr1NrիҗyYR,kΝ,98 Ip`j~o[7xck{(BUkk"7o'}Zuژfdri D[yHR"0Cu6>@r=VWt89y5;编_$Q${O\<,q̃:{lƋyW~IR(+u Mtk !_Q-kk(J\FXE&c&ϡi<FLWA^|Y6՚DQ n/2O(*Õ@R^ a^0 `̙-Job*,ޫW9 ш2r$I\bmɍw}{il@ DQ߿KɤiBC?g7l|3|LW8=6rG0'llUf36`جm~2eBcEk(ܲP&yHtൃ|IDAT T :}ȡ^?gQ6XYbg"0a4 9(T*DZ\._~`WoPQ2oXh2<X..w${z78Y_t;󃥥g3;~6qt0)"zV^[; /\fqqj$EkEwBҥq^8glZ]/hT>_Ȕ y]H~|4x-f췪= @[jr{YYYUBt육r]Kt ,,,PՑ$vC88z_o;YϷWߏ\pM*a/~sx7A%&a-(diiNCRM0(Q#)'/eYYY5.5+Kb%+0d@ 0M DZ(t:M'njF#<4M݌︕!^x%DQD$>읝2~elnnE.Y9:97<)߱x饗T*$I&Nr~}mMa鬬25|c ?_>0q4]d>sx(eS[|m[_gQ^woKwu\!+Fg_wʜ;8 S<6N9c4xN8 S<6N9c4xN8 S<6N9c4xN8 S<6N9c4xN8 S<6N9c4xN8 S<6N=m KfSIENDB`move=1000;blend=1000;3H5Q M* UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@M; (       bеFXXLGX{ޤF ! R)/JRYH@$ J%˵='y$JO=$y佭|Ccens'Z1۲'xSyQzD``=*TI=)R2=cZ)OI={/zblLnDeiš4 0X4Z,:%PROI㔤.AgxKYqQ<'zRI)JI$IHdpÂa(C$ĞIYEYe@e,,aZZs-kbUUWuNs]US "m׎bu91[rDYu!rִQDg, (踚˴r 0ҍ4ӊ e뎪s kc-λYc!`ջb"^уbb{B20a9uZ-nb08 "@a0CCdDAVH^cq e"f#5/qaqƑ{)I*xJ`t )J%J&$!xP@fbh%Ry'JU)RJJe̶qbDPqַelfd722f1s:A D :NOzQS1Vas/>LDaxl{|DCnA Xh:nsv[wcqDG[aصr  At-l]!u9 2"£ifdffFט՚kf"_{LYca;v]CZ bֵu:]uywWUzH +sͻqU0Ӫs(.sØ1F-kY-eЄ!u9rcش-` [1g95h[ (d1ֳGDu9׵YUthQZb)l0L4Ҋ(!ʪn83[iÈ 2v򶜇Xݶ9shᡱr)bDֆQFCWU]V73abXQ9m[1VriT#v8ȰӜb)Y4c(Bг.K9̼,-a$eD$4ӎ^ȑ"440Dx#J1 0iu1tsvvm?onۻnŜr (20ꫧ-؈tL>0kkFV 1Ea2& H.0   @||P>AAA@4((()4  @%3Τѐ!p)P$$D5 >=ahJ2OiJ4RQ$YBeYcG `DQA}g}VX5B ,ڦ\IH ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QB1/"&"v@Q ?'֤'Z'ZMjZZjTQ֫O'GUZԟԟZREj֪5'ԚԟL&LBa@ff3?jOI?IVDI֤Z֤֟iZGIQUV''֤ԟQDZjgI&' "Bh,B fUUUTUUUTUUPUI$I$$UUURH$IUTI$ ""I$UUUUI""""$IUUUUU$DDDI$"**UUUUU$UUUUUUTBI"""$""UUUI$I$""I$$$*"$I"""OUUURIUUURJUUAU$I$DDDIUUUI""$I%URI$($IUUUU$I%UUUUT$HIUUUUTUUUUUUURJ! $HUUU$I$H$""""$I$?~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???y$=?-3@ÿB@?@/?@/?@/??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xConsurfoPNG  IHDRc IDATxy\W}<]Փny,ے<0v $V nBBn$B yY xD-۲dY,s^ 38/?kZzw٧~vmY5|'wY2e,Y2e,Y2=e}lǿ[<˼:G,e^%Kˏe-^x_qhY<˼:˖gL2CYY<˼fųkfY<˼fųkfY<˼fųk☃e^fsQ.׿n-[e^jǖų̫jd񉿤A_1e~ ^w#"2RQY!QַoG @0_>2??M⩗h9T% BQd@ò,4M&NE~󑏼9e~ *W'L1>~}o<+3Y+k*n}#ss^ev6{y|*w?ϩ. .n8 3|^uYl6O0jɤhT~'Q &&n @Uo'yoW яҟzv'eD{Xr5L'CC}Xarr?e noS,`cr9(S,yo3"сYv'9 M,3y3/;FC8\òf?M&t:*νD0B%֬ŋD",[`levvݿC"ZhJ^t_~{|#?$:KDߦ|ض{تjLsVcۖ-ԛMV}}V˃ LL\B+BQmVKر5 >|pQ 22U&k! p8)Z u]ge:c ,ȳϒp9h^Ό$oz]diV]27`:̲sftXo/$%TDX,͟? CC^ɡC=,PUUVk_{i2yd٤nszqCnwzgp#|?O}Ժu}2D 4&e TV T*s8q1*Y>QGtiD+7cYmr{nV!*QGG:a߾7-A}}AlߎnHnYPFWke(#Os򗿅nv yR^/vD&P񼒀MN"A3&s! 9կ9s&(CCN<IJo&_q8fq8hL B8eImTuvK_zv8Wr:^nXjTfbI"P\X@xJ%6C[A*Ǐq\JS}ikX  c `6i)|$_k4~VkIz1Wӛof0"m69> r_W} PU V,(L\^i>ֲnF^xi28uvzf}]WP*W,>vﾞn3C v{kKNJ˽hf.(d58>:s3I˛%YEcUmZr*щ'M#x2q=4\!v^gZOj}M'ثgoo/hB^JNݦ\,:O˭/|Z(47X!r n] "D"QV5/I"[ruP(B(Bڔ"q(JrԈF V Nw,vA(C|4mdY "۹`0D,&cD_8[I׆}< @ˍ;r׋DTPu,sdz綐/WyE\r%nӉT &e]$Qo6Y}~VlLf`^(.{k\ ùsR*m0==\zG``bL^vE0ņ }\~$|>vΝD4̙z YKbR9Z- tbY솓@`т5M,BU^npt:Ɩ-쳏l6mur EiۨN09//^Q<H2䞏~}p 0t S\.7pQuT CwwIR5" F$ryp8ŗiZ BVۻA("^$vffp8'RسԩG\lhFZ"a& 2.S(\r`vz&INwn8{@4Μ9(j52F))i`\~z󪏭?'e2dy -QvL#ߤc 6tw30K$3??ۻg^oni[j /ĶMt]C*̌j&( "Hp8B(`tt A2ȲeYT*6д'N-Z&]GUU$Idff ;(JT*Dqp؏FOXT*ѣG\&055J:P~?q칇 P}7_w3o n_ xn9x\& QV?|UD"q(\.)ftu(kannJEAj [+p/_TAjHRqo?Flm Ijv$qDQdU_.PD ,Lڵ]6DFyLSS(mzI4(6t@ H,vɬfh $=[GrQ"\Ju)I$x?[Fի4Z-2mѨ(5$J2^{ NЦZ]p0>~#/NlwM,q1n7fJED 1=]4UR0\|>dž ^oPK' CDAE#OrɓOn|ɦӸI(X,lQ!Lxٳg;GF::tv B\wAǯ21qAdMw7D&#GfhΝðm*ƴ(WQh4\9 !6mZC*bŊzzz4g("RTUnΟ`ΛB 򳰠uZ0*j V  v{Y8tgp8\LL\04 CGD\"&se:@e,Kgrj2nAFQx;ԸO;:7зjXnyT={nر,VE"'!P*Uټ1v/oxy'\.SSSn7wOo4}(Tz,nw]Db8x׏_9;uKR!NC{OB0Hya0Hn75Dܦ^3330tfɫLUtl3GSU>vUurebqbn(1L2! sm7RI 3 4 N>Ƕ-\QUjT:^o֙c~S[ə3w#KUv}Ʌ$ꧣ#L4F t{\|}CpYe_e˖kI&c|G(ykRx$EZwd5.F^GE " ,b_~CCY}}x'NbdYf+/׷nsg_p2R(IbxF}jłR$5\&Hy=/Z[UI,,뮷˭ܙtr((̳23;j@,ё嗟ƶmERY9|>?|VyUU0 Z:T`@@UN>$XSב8+WB"c*;wC.7ϗ`|yTUF%i\8b^/~TΟopؿr\:$ٺuO^ǶmOt'$122$ɋ]$z!D,i 󇘟 v (ѕ$9*"I"Eő!ҽ`~VI8e(JJ@* oCD+T*eYz+*Cضaj)E\.133Îٺu3Y4(+r+9E::[d"A8&ߙ!WuV  Aa:,Rb*N,\nd::uq92a,K_A$N"ч0:Ȓp4g&In]HD@U%^ x="^o.$Ie~B.gލa(lޜZ<}HK\.tUESUUO<`||1.\]]}躊Ӑy,#ORdjj˲h ԩ"sssL_B,wq~+Hj{pqj5ijq73=]```ۃaj5.\.SVٸj5&6loUo^h[ؼq_/8!Nure9vtL&4H@ ˏryR\*T` V%jd2݈jefGC!m?^1Hx?lޱ}}Mev LMLn= 8p4Mczz~>rSlڴ`0s39y$UCUK4u6:tLgT/oe/_ xVۋv:ͧp ~*Xjjm `v$n4M#FB|ÿ&7l'agmӲHehb0@Tn݄mBQ E YT$_ t i}(JlvQ͓NG~婥*Uz8wP˃,33s޵hZ ˲ R8WJfN,Ϗύ7C@I׮iL1ʕLLhr5p)ffFi6( x2;w 1M4#S*P[T!rNIN:N8ѨGYX(b:?G|[w%(K$p,Mq8LOOmVRg>oUà+$ \ Q.{;s$pߵu$e'ΤVg{d* NN"fFKtt] {T*躈'"E C4E0ra.,KEQf }X' 6`0n?Lv͍7 7@dt[TUN'do#s[==6l=Hu ۍ"6yQDLS!` (z#GFUkj Q,177I0aXzsw߻yذamg;غvr\^#8nlۤRQi6(t8.WbqfI٢\(bޫVaXMEannz?ۻd4pGc*Pz(&GIul(|"\uMU}I$'hh m ]W f4M%PŒT*sD10Foev~Ӎc 33Wm`]W?-,uF@jͤt !x$Q,D4\*DF /<O$iyldd /$],jQY?J<铈bH$eYY~>10<| vhaYOR|S_24 V12R p,,0M;P.[Kx<VD"Gٲe?^*XӲd5lۦTR*ĂAtBuV[jŋ^&ssDgf1M<]{6,3.fY=|>/p(D8NVEo^aw%m#t:Dz:.W7.WG'ۖ)oT4Ѵ2#8t]DQXU *Rò <ͦE (9nŞ=7p %ٺuX[w}F.n vs؋\߿QU(2_*a7ڔe'\JsshqdUX*!$BM4'$s9LMu.J#Fٺe ~AXj7.b IDATWyLx6KbxfŒV'ӓA,Xg^$HtzB46i*OY. I3W1 ]VQ,_rajJ0jX'1MB8D+*CC=x]|_,??%8~q>N}ؽ E fÆmjTUl ::Vgi4n7~^?"32r]WlOMPUI*b1R._>ʕ8m?|M8#]ʢٙg``|'n u63:7nxn2>wݍ EAudU4MX*Hg;Ra׮1Ep8nS5/ccMYl QOUgժ6/?21"mkBM+mx饯`2~ݻ߄鹞HDA4AdvvfN٦׏*?wNg|M*>P($|KL< 8mDǏ[*c*m`6pG0D/s *XC4JƙLN'Yg? @BUdUP.32=֑U*xkn"Ms3?l*ur]]BU5E^zFx#4&Fc54H$öems; ֭oi6\N֬ M+fBS`v^f~~Y.c2*R*Sh=O/xrYw'6S4-j*Ig|*6i(5::tgt8U\A}vFU0hc^L`۶xmg)R z {:X2MQQIw6=F0b׮͢*VH96qzl Ӊ*(5McTBw{0_V9sa *1_r~tR(Id):rױnv!ĹSPh:Q94Xi*CC+9w<`U0MgQ"v S((H,hͮGU˸\n!H NDBzof[mfYs PO>e&'GzdضIacLkƙ(.Pi6ضFesõ;Yf7쿖ӧ{WBER5nw-.m۴ZM4@TΞ=UP}LdXjWG0tdvﾍ҅z;.D˗q,#/SSrws㨪.^M6eU71wC_#F''zArG>$U)8pѨJEbŊ!_qYIo㗑e={rIzVpw7Ɛ(2Q,L$rLT7 ]mcmy8 ^o'q8jttD:yd\\Dᛑ󗑤 X>(\r1 ^Fع+8^ h72KOOzguZ&n H4- x<V̡iSSLs]yyEyb2۶ĉ,Mbta1i5ED J(NMa60F_=̮]{PU^t]#f:U':Of8<<)|'tu9). -fON^$oczB_J2k~bLO11qT*w;oF$B,Gߟc͚]5@P[:L& l 7Ν$ x:I*.FXP3 MCU]_[eLfI&Wbw,z(D w7pٽwfժYbϲ}]=OP)ض,7P73x<. Q6`<%$i]{ﾛGIJ4 736v۶mUXX&g~VP @4'L}hj5Pł+CCٳgHT&QոR(ߥ1"'R4^ҩHH8L ĩSHL08s n(R EH%)|} N DWWWrh6KRA&bZM&4l 0J`6m&eY\ڕU$BL2l߼CG`T% ˅ݷp iXz(ҎÃd]ws[ߤ,FPgp֪j>_XL soddd+\[mO \L].4@3 &*G ItP.OU|0v\:ը晟hx1 vɓgժ]DWWFæ^8w$Hq:Z-B9,K0h4 t};>VY.bYNZVe}$^Dqz"$ϒJՋ ,uD2tߴ]kwjʾۻs(>YeZ' &o~~;DNٻ~ U _XxeBBPh* fVIf}>~\N'W5|SODS)}}\r>Ue\9aّ$1=~~?fj%|>/,v~ATk4۠CS.iV]iEZ!S+D1HR+u&]o!! DXuZQ(hlmQ\ M3X^Ci8b1[[KKg, Ð)ב"OJ%O.F;9|S4~h2#i%AJ G 5 w xdƠRfee?<ѹk~n]DbA*(WlrlHӓJNp7.]{dq}KJȊB,X2d!( "slme0[t :5,,T*%^ ,v YVQoznui2.w9>Uch6;PX^>KavۏQ꺁aȨj+?ݤ%fgt &F&32ryf`ڵpQ'0?^Wٜj&JTQ"vPhtzu v tBa'~O.Gv[,;;|ܼ9iJj j5ZMdl>zzz{ɳFՠ04 U20p+0>W~fӤg<Z:$>0=D:=EB_%fbCRQ\DnbjwF$)cp|$8kT*D# ph?F:=ɕ+g~zsfggJx<^v;'mv$<׿udJEE\TBQ$ff{ȑS5jӠO~saoSh6X:U$ ڻ$>s. vc'Np0d n+$=!^a]G(^=y{Ffppd2$ 8>[o-id 'v\ۼtr:篑JMR.g:>i4͎RdϞ[[2@]wl6)*B8lrPL&p +@OOFM>ˍcCUt]…ש:Je6U\hȞ=&]Eب"{7{743×:$)ayy;`p0M0" a> ܺNޢ29z>b8hM*Ջͦ&N7ޞrba+%L#HB!r7fs5I"`y<~?(05u0M Ð[>>_tz˗AftfAg>N"f<1@6XvȝM<PT~qx] ӄn.ݸN>T"H;;[[ I$nޱ1ʅCA?DDVyV&fgnstlwW\qGZ.?;H<.'YcH? /&'#>A08F*dt4E:} =D) v$LnxYe|6z(Ϯd𬯯ߟQ59a_Q""r}ri}xdžYXF7 dIT.cs!|n{8sϝ0:O dL#G7Ѵjd5L0$3:zv4 op4fObh:2kkdj5FCj"&aP6vMӨղyL44B,.f8 .y^`kmA:W-4@שjd~2x*~Zxp=s/ o"U< vpQUx<⋔J++BlvCS0({?(deo# W% 6.Vi P i4M.7ykkzqG)2J8$ӃC dF8!رG9v1ￏ知^h3* IDAT39A:LLAE%|TUfp0o?CCO]; ̒HPih(ؘ0@UUGQdLSPئP(Wp:}lN67h]WÐVwx㍯p @fgs,&i.v?<-Bh]h7K ,A*T%Μᮻfcc.w={bڛ< j4T~ pQUY`ikTGGU(PZ)i"*sU~wXZ+,c;$l{2N3휈i`-0ndEAeU;U!Ko8OիX6t]tdYD$;;Kb|1$ߥR0:ݚDd$:AݸCPEbAeLӠj;{qt]0G>~Yzl6V+CP zM?vL>vGzCxAΟ\nA(UNn={N Y1 Ix;$R),V+Q4o`Sp*9DI"_,w)6oC4BZŬ?ٳ Z5KRRCB8~n7Ͽ^ Kc-R _jc@\nMSh5$YFQ8VװX@$W2u$?9vV^/g<]PZ(`w8:y(Z ob:P/pˇahݎKA٨#HEYgffãZM^z`k띍z;BG|@ ĕ+ab'lof 6JX#x<~"]]UuQ.J@So{|yjL`Yp;]m0.v;DnFjQi4XX~v}3,,\BU%<?6 J7_ E)\l6/RD%üCB3MàidT({Am\zkq\UEVk7ER$lv_ޙʡ0+˘I^t( Mř>͛)Db]222.v 'Y]*a o6XDdv`G&3nN ˵f3. $WY[DUR;rX,Vyr9O `;AoE$sve fZ4&vx ^S_F>&"b$UV\5~W~gEf3>s*>&U (T + Dj sssg%> d{֮d)݌]8FFq}UבrN@oT* >)45n_ל(z }7f.Q\ΠiXfryXl}nVQ* ;4 ;;7Q RI(JvjIEQd224Z"Iya!4Mt YbzZADLS4U:VEEΝ{ƿ{?ȖZ 2=Mx|uVׁ!;\nYZ( Y4uٞB\E~?ȗ%u( O0[-oC__χ*ܺ+\f ~Z6/] ` OBcpx*Q&Gh4xWƨTdNxFԭ݂djV }tzۋatcBXXYVsdl,^_@݄}J9,N7Wu2Oz]4UJudV]$F*3 Xw emmtڵi4rx!MfC$FxT4~">>ǘFtJ>_ѯs rBmJ<_x|sLJ>oy(Drc! ՊuӤ&ҝ|>ЬPf*j ,#* Μa{i6"awln^#Fq\mry]^䝅 iPupr5&rbZ&C(XuFѣj;AFG(h!I(Jz]0$yysz ll,200˾}{C߿p S)&V} 4M"e3LLLwA:xIS $Q,i KK`ǦFtzgNNh4 P#&bXSS'yʾtL,Ʈa>k6d@ '8:D`0A< u#wQn6;^/cmr9Q$Ә&?$>]Uu@/< #aXPxg t8:gt%6nd"qx|\ E0HhZyuIZbauCi(t4MB4u/HLLaff^6>"4VkPCquR=4 rN1?j5᳟5GdbbY(GV>w#TΝ{Co{}O<1wr\vFAjպS&.î]i$IOc;I:tb{DQ8㘦ƕ+WŋxMR*u޻ƷIb鴋 V:ۆw.\txd"HGVJ>y7 I 7P._}Ӭ%Pj H%vvx)0Ns)^|Ne|| a(Jʼni*켅 dqX,6LQ,/H./x]a%0^`0i֑厹A(ݶpDen400q߾1,vX%$P(zy/%0 _j~zQlv&B,*G:=oj-ݍbU'/sK9݂Պ>0@EX>vnshp zz"hjj7M͆jQ-X- CMvvo|Tr9PNi3'$].=D(cd ң?ϫ>a(vu]f x<"WODqEYT!f뀦rhںFޢR٠0Ѵ*vf3lwRZP ![Rv&ρ@UxnwEuovؽ{?s?N__?6o|bۻwG3:2Qs<LA"~aj2:zB~B;ܪJv38H8D[^MQX(p%7) w ;ir4S#kMv;rA41 ujl:FQ1l6Ɔe4U\۹Lq+ xLx+ }mw*],Y&Lb:/0\tnw\&V务e5P,ij$(EU:Tg_jT@l:V'~^!I&{4巩dC{ouZm躆VSH$z Cx~&''> H$R}.MW?<5FGwBY^cN_lvUCs{/}E B9M$`1| zW9rK,ު00pf6bU8뫬^?0@8R& #Ot QQPk5DU"I,ooSTZgty-B7ncNN0˹g"r`4Al.@rPQ9VF3<9mڃ,m{ԷLOOmB~ vh!GOp&zÏpⷩ4d@_Zwb6[|3cٹVi4:6z&t]Y,6DJB'~g,t^;K6PUjJX$-~'0E:LODظ18[~ __, o]`+901eO(Dadh%Go6qT*l߼\.ַ{n63n7vLapxL \cݼ%vq|N?vAXwp/7"H`;4ӧefO HxzD.rCd"&yD Q.kHRFpi6)W9pgBC,C$l6x\ZmVVn;i:ZzG<xfۆiֺZm'n\.C!p8 4&=ӣbff܏SǞ+j8'?I*{8zE4wryP)TDb"\I(D"Ax0k5jN:?a.|<00Lo/Z SU:%Ӥ47Gulb%6kwRMEBeFG'U-rg_sxlۙ5NXj {ǎ#H"1udYbkm^?dOTj?ĹWn& x |W8yO⑙A7s7h5TQP*1>}?'q*TRJH&$hI!EV _` }b>>^oe2T~]%7 ӃTRz<>?ONPPjcܸq]0LrkkuaA^o\ YhTTUGdVnN_"A4#~/<ۥJbbqz݂rRi wÐ Gv6=SS,--a)M3iQMi,b0xгP(8~Sb(6[Z"j]'i*Qu[b~N8AUƻOŃ'Oŋd Qdxr]Y_B+Ȳ@&o[biwyj4m=$v4##zןfxhA7趎C'_R0Mcc288E4G<5oVVLL&6~V˂ K200ks8'jo $=4? UIbUǏ4$>p$CΗi,̽"H @vuۍ"IX4 Պnoc6_CݤRBbh:5UEQx)`gh{]D:=fs F ìv{VK?:ǧL$HxNF?7Y :Yסݦjtq:xvr| ph}_tzp,ړD K%WVv30>NV<8}{>.]('|qB#\rCR U@T"kVB"*RN!P4.nm DBwXE2?:Ph:?lq:cs++|~w݋\dz=x?ܹh,WPzIDAT"oRdH&;vҷ޵MqTUV;<><^?:YVYZZj:wu_P QU k<[ş͇ǂ'W.+IX7-JF;"VIRAvBO$Bִ8_ d3uH9Gun./Sen1DG9qnK]v:I0TDWxb&xL* 4>p-t:1$ >ROٍ $EݕC!==TEIp9 4A@4<>n!˚F#7@QGQTtBo_x$RigC<E$DY&W,R5iT*~KjӃ륷72XVHR-nZ S.U,˱w燂*r rhZӊa(&ix}>walhA^fy{UL{N䭹WDk(vn76MUQdzC9wvvE4?s?,KHNvǃjV3;uݎ! !I2/2,vW۝1Eٳgel/\mtݏaDupOg^?rCX422v$ \F4v to/BcpHfġzӊā\Y\px8w/^M ]b2reBYgggr( m+rN,O:;;vv2$IX4s:5Zdvzi7;;HlpS'Lpd6VlooS*h4367j|k~ZMghhCCey6 YEE:?BTbym$yq|eAs@n#d2j&Cz<"a/R>O^'Wq4gh Zg\fwX,CE[[I'hxdld$?b  \ػıoml2=^/qIfoڅ,tcI&88+"~?gU0==ޜ#  p:T|nssW~aNd " n/}~tvłK?;HS:hTGrøv/\a)nm1>2BOOuvEgx8IY\~gǓD|~,+KKo{翉c*7`O:p2I$^eqo"p #ssAĦ(ł3l68trXN^]CtqZ\o6}>Ng'G{.V~9z:wΉvz٬ԅM,@<ifebP2 J.G&Cx=m~z;s lvKۻ߶;oR4DY)˚&FnEM ]1vُ_zP @ ;EKQthVdi:q8QlEЖh"ȬV)W7u.$yH>~+d2AO ]cUϸa0L|glk8L:2^2AMy ' XvTH"A?u=%HؠpXw{+\R4U`|l)~{ (<[X`,VutUPU\Iή"L]UٰmLD ^?R  ͑#Euyusr:}6x; EN̰/l.F]jtכ$ G2:> uH5,ˤTkPVi1߭7 2}oIRQ{@ð'((3p{eߧQD9j5uI> m O6##dG5_J_(f.[t=]S,Ve5ccY&|T*ͧ.n7д'Y.E7Ϸ#k43S0iE C2CUI$Xv]rl}F.*}V4C'N0h4Xq_%L[;FdDgk /t]nwxj߹8N&t=nOu9,6(Lom- y{5@ZQ8MF 7YV$?WeLgi^^U)j89U?29:x:{C5\xT$L.ң)=4Ͼ}>cG.Dy*\EaULW_ʞ ] } MCU[v=9mG \/_|x}%#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#&#/)aEIENDB`move=1000;blend=1000;3H5QMM; (       bеFXXLGX{ޤF ! R)/JRYH@$ J%˵='y$JO=$y佭|Ccens'Z1۲'xSyQzD``=*TI=)R2=cZ)OI={/zblLnDeiš4 0X4Z,:%PROI㔤.AgxKYqQ<'zRI)JI$IHdpÂa(C$ĞIYEYe@e,,aZZs-kbUUWuNs]US "m׎bu91[rDYu!rִQDg, (踚˴r 0ҍ4ӊ e뎪s kc-λYc!`ջb"^уbb{B20a9uZ-nb08 "@a0CCdDAVH^cq e"f#5/qaqƑ{)I*xJ`t )J%J&$!xP@fbh%Ry'JU)RJJe̶qbDPqַelfd722f1s:A D :NOzQS1Vas/>LDaxl{|DCnA Xh:nsv[wcqDG[aصr  At-l]!u9 2"£ifdffFט՚kf"_{LYca;v]CZ bֵu:]uywWUzH +sͻqU0Ӫs(.sØ1F-kY-eЄ!u9rcش-` [1g95h[ (d1ֳGDu9׵YUthQZb)l0L4Ҋ(!ʪn83[iÈ 2v򶜇Xݶ9shᡱr)bDֆQFCWU]V73abXQ9m[1VriT#v8ȰӜb)Y4c(Bг.K9̼,-a$eD$4ӎ^ȑ"440Dx#J1 0iu1tsvvm?onۻnŜr (20ꫧ-؈tL>0kkFV 1Ea2& H.0   @||P>AAA@4((()4  @%3Τѐ!p)P$$D5 >=ahJ2OiJ4RQ$YBeYcG `DQA}g}VX5B ,ڦ\IH ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QA_ConSurf_DB_pipe[ [ f3H5QB12"&"v@{ 8      @ !qBD `(l\0\> &ڥIi&if0"`04Y0*yIc43 &i2P!rDɒ&:L$i"d *Q}@J&P1(0HP 0/ ʂ @QecZ] emYt8E!0>XB L4ag,A'[(<,-46Ӯ,g:6ͬn,ˣAp'uUmm4VmuviieAuW]UK,qZmu:EqQq"B"yAWqWuR(86$Ȇa .(@@ ՙhi5QͲl, Œ,ͺ&&2ꮻY`R]U\q]]uBP`d@ `"lXThhlXhhhhlB4BcBCCBAD􈉅VygDlq$HB ! @dW]U]quQE""AQa:ΪEQUU$H$z6$".8.ӊE$(yccb14"8yg Xd,(E 8Y * eqԈ(e HK,੧UtV(̜)sNg46 A֝uiK=mf]h񱃓Y3M]<,%Dc6Z"x>#"QO"=%]g6lU9Sa6[ifHMs!0X̘C` $(Ux L1P  +*LI4R  1@bp YʰHtP$H3X&Ht\ $Lt鬜gMY8(L T(:Ht 0&"Ax@`L#I&TBy0 s,x^(a0`\3*, Q 2:N8ꪊK2N)ic, j0+0c 0̸c & r̬-n* "8@`8Y<. 8@"P%" dD#āimwQUTUDeRh!H* e5tXQQh L0aJ&iaCL0Ҭ0aUp*aʚ!iT*k2m4SM`ҢM4SYCA[m$*ˮ ygPHƄAƐd11`-M9R 4 2$‡QYY7WD: 㫮Dhi[YfVYmq%YB@ @Xc 2iSM0k, g…XPҦa2LE a3mSM5 ,MmwY8mf8Y\|MeMfefe] VHE%Z@bbGh00D ' TN `10"b`-TM6V16Y8OQF 2q̚-'&rɲ+&TM 1`QS9Md# -6Mm:,NۮӋ% "6&$I$(xB HpB`-@ZiÓa7]qUV( T&ȘAةEYUHmfUu6T131eCaTQeʌTQFXM4M5qaFTa61 †0 (24*@6 [mmg]wU @B ]t]uu$RuH96E0 $k(a blTuVQ a3ef]fpG8]TIU%Q@T#(Ppt8Dmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???$=?`;2@:B@?p?p?p??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xHomolog superposition)PNG  IHDRc IDATxwE=˂y{zzN=0 # E$*(A aaH#* J첡?~;=qgڿϧ>3]]]]SOG/|1|1|1|1|1|1|1|1|1|1|1|1")}>~pG-''''#%\%ﶏ6Ss\^v×y|d x|d x|d x|d x|d x|dv`+-PP^a9&0o'9̻~9p|j0 o1>+ UNn/<0_E~ɨÎKc1X0ˡk<%wi>%rh/И2_+"ʪ&~__~`Rv9 :C`uaX_| KQ]s C=;\oV]uqpx-ө+pGqh/{tExODD<;@8yQsnՅgpe@ Dƪ3:ٶ.#-D,^@cYCu%׏@y艺!`)?  Ti+Ne =hi,l ׮D<×>/h⹞8Ϻ@?ļ_C'h?d@hts:U^SFj풷߁OB\ srUTĖ|.<oؓ״Rv03|f|n YsaHqi\#Yw0 0U`s4ӻ`xLO0L3}`ƁYo#r| lIs^(R n)6f(\c# ػTI$tFo ᓩypelgM.:FӀHzhLS(?o^Mi}:oّ^ϖv0gauVi`a 63 *UL{Lwu*直 614] b˿%3^sc 39xmŬ6ZcV;Ԙb^=a1jw`i fۮ7n|LkZ,nÖfqj:'z8LuѰX=>{Pb f;*R=hCn.Bk6/0tӿί e@#J*d8vmd+?oT&Ae!.xaӰBT4{csszp$XuWN.n\oIT0 5؛M\e0kB`>CgmC O!M [;ӻ6U޳ -0LŞy* ]ds>1U<;_|9%%pՍ1 4 `0kw` }E k_>b?=K7 ;f\ v yBax!D(d,^D\ @un mc+0,ź~#HHUo@(ufgnơAzBma꾎<bxsü(D`k/uv=g2#V`= -1ø_#fb~Ȯ`$̺T'M=3݋D W=hCrls-ޚ.7mU6CGP0 ͈kӝ@iPw9~4Ouóz1&QKLP8>ꪺ.> #Ѽ."vGBu )X9PҧDs%W p.{C'%SPO*LMFa!_$`j>ahuGO+,k W>ĩv!| f#o[bnq_YρiZDba^\{$ƙV,5őmHmczk`xMˈzْ,ZeGc@#NA3=]ûy审v:Chyypl8mb{;/jG_AogFr #2q?0Lopy >N/bv @XJS_vw`BK4N󀧆r0Xf:C6ehܮak {sTɏ&/l=碩J@P =C:S`v^>.R;A IېL= =6`x|f})Y,jV 0/x4fc-ʋ`fG1JƼ7>'5#~El4ݿfV a$^А(`"0E'~cd៕X!|ыm@pV"<&$Q@`j'ˡxu8r`dO?{s`v5끙)]~ x6qpDNNoU$Hd'0ȂB8HhwȈ\x'VVXvB֍ȌEә˵0"1S݃RC-޾qHm1܋6 #C#yYXE bxA>YiQ0_8Ym5K cvpR3>u"+uc>2L)uƕc$spPxKºa(0p9v LwDUz蚋덈S5hzn^ZSR4'kBH]8惬,3 MmalA} 0\$$R:S2[u%[$48f=ׁbk@lw uko$GYΧV]^(>b,ZuDfW &ŵ|VXLFZzdϺh|5bk [a(Y咞R2K[Mp/H ϗC &^,_GN+mybgc=G> X.%L߾lFQUOAb`c܉T㥐eY+XU/p@ [!_) ^(7S9(JweJA(= 0 |f09zߖ#5D [v?tbwx&>k \rvqJP]BQVPR M بƢ> VBoR/xoyAC).G kY~h deeq1KˁsCTzTJ`9۳ޖeK)^]LŘn5Yv(;kG͈L!_v6~,ZdDi``1iH{uF=|DmJ5ҚH|) K #Fbo0C # `>6;փ݉[ْ^CBB[怙sur\r*KK#dS0sD9~i\a(3rl-%0<3+&f '$uw6nXvg79LH8{{nWO!tqqo95hG\#y/JߛhusWFop `ȳrEZWγALw+j_T3S?lv Jm^VlBKj2"f=ŖF`N|8ۿu'-%XWd6 =2:0ر(umGa3+ap u=ܕL)Z_PQ!o%p9Lh*q  _Z^϶E۸a$Ԛ'.)){es# `0rT2˟G°< ^e9d1)Xj?DJI4}{4ԗ!Mk4D#햊@%9Ht;/Rݥ#647CܱW6Slbx lY!0,x`S9F )~'lAa:ý>ڒJ~.kE?-f+mL"h.n 4Z%cyO.(cSSfb{oyX0a-=(e0]+)]hZ*gog 0Q`э1t=k)ǝ=5[cx -SS+ O.D=Me\-2mOڡlh/g6eQikZzG$,ks=„;/;x8T7 WѫX7uՋɗw'0J08iJJQ:-#ۛhVbZM8w i.` iq^p/Ywr_@c%B&mb+I_ifKzj!hž%RRdJgbD,I *UQraLy0> mv,&ԒO0E6th;QD7FEgιIå,pp9𪸻;NR1Ql<`FeЃ+B͓l(!HLì&:xVb| ފMHHf8z1, O`SaMBLCCыlOy;''H)C}E1g{}9qvMҿwĔOGn2` 9~u߂.s%i@/u]Wߝ^Ǧyc3y=yIJױ(M VG''IQ[x1A;n+x w߰8N"B/`6Fy~PBnHtmBd1Zc0m;x5x7 'TPduB@==Om{4& ef`I~ZH7 #7Z7/wlxA$G}nq6 e优k?XpX{ i? T:ZYqD^[zG}uE#뀋~G4*o2\ Kus3}KZz"[v"a4&hn\ )5Q15a͌bNӞ^8jQ잷[al^mhK[~%ot}뉨z)s⤉Qh%J-C-+X-CV!KaMbo~B 5$` jvp<tư"A RG+T"L30&$*K/5wcnE'%>JL 㧊S>vuE'bwzmZI|ʨPu~ 7-ʹGGyϯPC{=XSQX'5Q"J-oƥZ&3=֞O.ocjeZ7VEDgS b5܇3:!M$!0\Yr-?ID-KRΤM@S˨`iJm x ΟH IDAT'kh,4$H \IP4gkW# G\=c0*'&NHX:۩OIlz—H#д3уvSOc(GӑA` % 7P|K#WJ; P5@iGRU9Ϣz4~Gdec2W&B#zQ,ʢ/\kR,AwAё{ "BȰdN8.1edAgYޗT0SuO;m:1D! L Ca˅zA.ʢ^C!EVs_е!2{`?zz6nB&_J d`csV" ߓJ1Tc [7nigcѵKߕ? 2M!K%r`IS?HR#Gj.hl }dvAa\+܁ecB\}$UϫSvb3dL\6YFbfFh9HwB(D@+DnG7k?TZYBذ.Br]9p\wGuGy5hHDX w!*+mpE0_KȪG!u'sVQ7Ko^X_\'u^5 '{~TZ47h43ha@jf u=AO\/nR;~;=KfdDrцAp=; + =XQPٔ^~%ZM'C˕ ϶xMq{OyO>~?4*uC}wM9f e]E&'ba}u4X 0a"Fiߖ4|A'wtPL k[(m7cd)v2>zD_NB$u\2( ALV,l̉?=@&, >+}&"ۜt:yݷzc:OՎxt°D9;8Xܧ 2)OS:+ccQ>qD} ),n"ăgc}P̺|x|>(|&f|̚K.1{;JG, cctcI_(uX%'H/їS] =]1UVѴ؍R U%CD<sgsL7"r aMYYQbpe ) $`wFɁE:,f%耾h4BSrsh'8bJ=!"%j=u#޼x q\ĵD4լ|^B^y7)ITn';ȄC\] :hZ6Ugd1m͉E1._EDE2Ut%R&@/Wf6H AdYO~88i(|:PWEEߨT{{ek8ZFs k߻Qjs]PΨқhV 5/&] @myc?Q߿y/_`f(uXv(ch*1ž٪-!51WlXaYu~{0]hdwϖ0dH)͠aݾ) R>;l1o2%v9KQz8Ґfnwɖa-&#!o>EcP5*faI> ^ڥEȫ MH|qpP; r) 1$>>qԫ`/ؗ_9~}!O&O<>>>>>>>>>>>>>>>>>>>>>>>>>>>$ W5IENDB`move=1000;blend=1000;1BRW  @ jZj*5KG֪֗j#MiQZZoIGRZ֪֩5֚KTOWZZMiQWZ D!@@H"!! D!@\* fI*$%UUTI$I!BI$B$I%URI$!I$UUI$$!BI%UUUUIB!$HBJI$$$!I$I*I$I$$I$!I$$I$!  oactive siteac1QSx*1binding site for residue po4 a 2001ac3QS\l 1~binding site for residue ca a 3001ac5XZ 1wbinding site for residue mes a 6002ac9.01oactive siteac2QSx*1binding site for residue po4 b 2002ac4QS\l 1~binding site for residue ca b 3002ac6XZ 1binding site for residue ura b 5001ac7RTr*1wbinding site for residue mes b 6001ac813H5QMM; (       bеFXXLGX{ޤF ! R)/JRYH@$ J%˵='y$JO=$y佭|Ccens'Z1۲'xSyQzD``=*TI=)R2=cZ)OI={/zblLnDeiš4 0X4Z,:%PROI㔤.AgxKYqQ<'zRI)JI$IHdpÂa(C$ĞIYEYe@e,,aZZs-kbUUWuNs]US "m׎bu91[rDYu!rִQDg, (踚˴r 0ҍ4ӊ e뎪s kc-λYc!`ջb"^уbb{B20a9uZ-nb08 "@a0CCdDAVH^cq e"f#5/qaqƑ{)I*xJ`t )J%J&$!xP@fbh%Ry'JU)RJJe̶qbDPqַelfd722f1s:A D :NOzQS1Vas/>LDaxl{|DCnA Xh:nsv[wcqDG[aصr  At-l]!u9 2"£ifdffFט՚kf"_{LYca;v]CZ bֵu:]uywWUzH +sͻqU0Ӫs(.sØ1F-kY-eЄ!u9rcش-` [1g95h[ (d1ֳGDu9׵YUthQZb)l0L4Ҋ(!ʪn83[iÈ 2v򶜇Xݶ9shᡱr)bDֆQFCWU]V73abXQ9m[1VriT#v8ȰӜb)Y4c(Bг.K9̼,-a$eD$4ӎ^ȑ"440Dx#J1 0iu1tsvvm?onۻnŜr (20ꫧ-؈tL>0kkFV 1Ea2& H.0   @||P>AAA@4((()4 44 ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QA_ConSurf_DB_pipe[ [ f3H5QB1Y."&"v@{ 8      @ !qBD `(l\0\> &ڥIi&if0"`04Y0*yIc43 &i2P!rDɒ&:L$i"d *Q}@J&P1(0HP 0/ ʂ @QecZ] emYt8E!0>XB L4ag,A'[(<,-46Ӯ,g:6ͬn,ˣAp'uUmm4VmuviieAuW]UK,qZmu:EqQq"B"yAWqWuR(86$Ȇa .(@@ ՙhi5QͲl, Œ,ͺ&&2ꮻY`R]U\q]]uBP`d@ `"lXThhlXhhhhlB4BcBCCBAD􈉅VygDlq$HB ! @dW]U]quQE""AQa:ΪEQUU$H$z6$".8.ӊE$(yccb14"8yg Xd,(E 8Y * eqԈ(e HK,੧UtV(̜)sNg46 A֝uiK=mf]h񱃓Y3M]<,%Dc6Z"x>#"QO"=%]g6lU9Sa6[ifHMs!0X̘C` $(Ux L1P  +*LI4R  1@bp YʰHtP$H3X&Ht\ $Lt鬜gMY8(L T(:Ht 0&"Ax@`L#I&TBy0 s,x^(a0`\3*, Q 2:N8ꪊK2N)ic, j0+0c 0̸c & r̬-n* "8@`8Y<. 8@"P%" dD#āimwQUTUDeRh!H* e5tXQQh L0aJ&iaCL0Ҭ0aUp*aʚ!iT*k2m4SM`ҢM4SYCA[m$*ˮ ygPHƄAƐd11`-M9R 4 2$‡QYY7WD: 㫮Dhi[YfVYmq%YB@ @Xc 2iSM0k, g…XPҦa2LE a3mSM5 ,MmwY8mf8Y\|MeMfefe] VHE%Z@bbGh00D ' TN `10"b`-TM6V16Y8OQF 2q̚-'&rɲ+&TM 1`QS9Md# -6Mm:,NۮӋ% "6&$I$(xB HpB`-@ZiÓa7]qUV( T&ȘAةEYUHmfUu6T131eCaTQeʌTQFXM4M5qaFTa61 †0 (24*@6 [mmg]wU @B ]t]uu$RuH96E0 $k(a blTuVQ a3ef]fpG8]TIU%Q@T#(Ppt8Dmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@??+1BRWAfffL?p}7+3H5QAfff333?p}2?$??@`D` /,@?c?c?c??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 1;CPNG  IHDRc IDATxw|ն)ۥU-ɶ܋,;l j7B ! ^HTB:= $` Ƹ`e[e-3|L]/kvg):ss  WUq.dIEdIFedId$IB$g'bM;t5F/@5~o56 CxuX uO`R|\|& @buL<[jDBxd~̾YV!tNv>cgۧ>, Ls 3'-gGO#DX/8Cu;=2xlٵɣ&Z! .4 CG74>W3~uz@p~CH o쵱tz2NWx?xEBgǮow0~,r2{^\]`M QhU~>> IBV?KW:yek]4>WyP$YQeCU;s2 BV5N  &j#I2aud̥\&gsEy$IyRWh$+ 1w6ly) Ww|1N@<cOB$ZZն$)>I;fǾ]476>As\?kz~x⿮Qpچ).$IiI;F:@qxgR=9j+8 UqiaRS2=yo}u<a80 N=M+[d8x\غm?9TϵOC]_qӾ@a b{x~ 2CCӣ Kc/7'ġ\yG{t}Fwe:+I=5vOYϿ.]< &=ːb2<`=OۉhQxkޢ+-/t袩ffdϓ';dS-t jBcޔ31 '^12s` ׿2JR0d>O*M-5㠌kx~9?c$+ܱYT7|r:eHh>7˨4H$L4hA֜r-9 n9TC(J(B(yixTE8Bkivo#=5#m޻D8=I+IOv<e햇Kf_ B aG59\.j. CUneʘENϣ C;|BQTgN#˲371qylCb}Wh=@:y~lf}$ nձJ P2 ]xB{DCoы(UuPGpzKSK.ՍD()tΥ姐@2,QytM׽!K2w(1Zǟeb<+lٵ|JǞ!Gi 70}:ooz:i7˾AmZGCD"-hzGw:HK%Ȯ:qit;2b$< x.l\Lmuώ}8;Ȓd$@a_Q$Zt !I2$P0ﭻfq\q۫;i3O7~i7 j@e류db6d{&)PIO=$>zgy;$Zc_GQTZZzqr q!j|$znd6fZĒy,znehlq梫cHrPe^ &GWX.YYh֓a8,7>x`-9e@eg؏`1u 8٧^,+i 7QUSޣxy1>*X=?tG{e㎵!X62$jSPR! 3"O#j?=ANF!$Q*ݾl) \q(w͖7[Rqn"ZCKySih: [v5[H(2 EQ; ,X,[FcR"h^H\g@v0gv@-!3Ş yRp)nd#ZpXC~ZZҮ/YH$IZ;8=94s(s>ߝ6Y+?ߩr7w0'a Ѹa2- vMn47z׍>2xY>ꛎ *.+&B(7JDW0ſT՘+˔=c?zcXpWOޜ|Ɠ3QٗWLS?g |XClsJ_5{J|\_C';aCRovv {jdžti8`jn{Soj#HO%}@j ~B EZz%ݺz {Ymj+wr1$ IQPi9\qG{w.?wɦMԙPqAUYH Bf)445 $z1zqNbsw!b=h rJLoULE%EY􉧣.j/vj/bŊ>]?}ss9<\}unQed>@h)xV.8!K`}>ܬ%l?P,nz{w)1ZRt:>:&\Ix ]׹m饗?1Eqǃi|e޼y]dg X! Uۆ?XHX.%KM>y\nIlݵ!;}9 [ .k#in۪cYx\~ZZnWdIAU:_ <|q/_Wl1pΝ>[v--bwyXbW^y%V-͒s|T1BZ:a֌ybl wN$\Ezy 5 Ghu &C$3.tKxWYd /w#/fȑ\.|>/1;bh)9#i 7WQ7,‘>?HɆ*YϷ=@UP[3b9ZφI9GF4}zS bĵ_W'|2os I-uY>'MNsd9."%.z_ &) T %]4YRhh؞w}ر'î9? 7pz+?Qb477sLCS}ti YVE.Ev֗4ݘni3Mkdqe ^m{OzJN,S҉GOITMȲJfZot>Ԓ+㩧g 7Jr;w0yr-}ݐ1:CIa}+iii7Q[[Cm] p3!K$:H,Q9)Ndm;6S<`H 9znR*Lέ 0Yf!᥸ߗ/?y\wݓ1 jқ\E$&NDUUFɤIHKKwӊ=7?Mm] 55448zP*&?{% Gwެl%K7&6Jqj桇ށRyn'il!~^(IP:er􏞢'M8b6:z"@Nf1iF#_)Ο]?_J L|Z77,$@ pʦ3J<b4&䞚KM6R=DpsM&3-%f8p pB4M# qwMMGPXr=^@8F:V?Bw߀S[V.bT 8=oSG:#:"Š!J74 bYv|$7M7F]Ǽyxz.`!֯˵QL3_9`֥HOO1lG,TI5-aj()`rQ0w(Ο(GٓWYWYV@Vq]w%g㼿}jd/yĬYvlYR""ŗ},1,wUxRis>4Ű"G2*m 66}w5OÆ߯vL\W?9u`޷\-,ȱA0%5 )V'xZ[w;wdΝL0Kӟ4|4={F7mh&+cRP~N^TKUPU,ϜWmCw=p5߿j{P}9ŘO=mbQ-үkܳow͂:?kYٲe˘1coٽmOʙgI?:>)!Mw|֯5wFB~i}=}e#E^HQ34Y,G쒄dw$Bd!ˊ؛"YMϢ]|x8{tk9Y|Ĵi>~trŨQҥK+.\(Ν+fϞ-3G{oՋ:d(wrrϊ_ydؔO^QS" rFF4qw'ߝzXqw}~-Kg"ӧ @~SNqbAA𥉀/]WFr)c1ݖjjtDZ[@F糡CF' sn|\Кξ/1' >>=:_ؼټJKm-6Q6 /40|֭[Ǻ6y=4mmb_OX҅.QO!í^>휗5ˏv`eb$1,w oy6M8o*u~Η;+m^?+ƍ/X>'lٲ]0dZ9i9&`֤̚Mb1ܬ>uwR}6TE7˸O?+VpuQTT \`邅g58~cϩ-k ;߼rԝ?1?@mmȪ㛒7-QtѹT7aƤf-0Ճ;(!%jP|} &uQ* SèYA9D`û9rG*y)3СC/^‚&ufcp]K/meں}Szj^u".Wp4S$LEC\U]9H(H(D$I:aee `UUwr2 eљ+{#2G^awVTۇ{jDPA]9.q07Uun:?s_{ܛsypCY{SL63fPWg7?>4Ycnt~ i(8 *ڟoWO C۷0yddY[nq6 @}P2Ph 7`3{) W|K(??݄/F L~H H dK'ҧm]/R DLJk dPBs=;^g_V*9TϹcEӣډK˜SBQx灴o9?1}en ؾ3JFLl|o87ܾ`J;L,1kS8{QOeR$  `IgR=(?zaa8S04C+Ԅ6q[gĥzP,eUVPSHJ ]IAiN_0jIo 8T#gS7G>s=%&Ў"YO5Eq1lMBk~ȕ :_:^7 &yÎŌr2 A]CjʭɲacJ d8=0CfƌÔ)Sxɶnz 4jyY# ߑ]3Vd*qO6:~EΒ]HyG=;/1C:⦶Ȁ.!-%r>cj`رa9XrS@ Ґ^෽8i<[Qbnpk'xDõEv[/6tQ-|bO<[nh,nR'EQxx<9Cr3Oee%tg, d9cRt*OSK-O5jp\<:^qXmQh֯W\f[<!DyBgӎDp#_t2d64XtTCNY}6z"?`렷Em2F jS6XL4'ּ6iބmӇZJ* cXS!!Bhll@SpBt.5!Cɡ xD"D"E/'%N5f@k#b@G(e8#MX]#nPXcǞϓ .}a BUUTVV:utillm#OɇH0IhjId>yon/F~R =]x=)Ȓ @7A[iAEK 8uDfӪjz].wK8\p|qDxV1 'gUli42YRY޵ Ki5j_];`?/BODҌ'%e>R!6˅_C6 ZՋem85h(*[wwL@xl.H+hk|19Х̌ins]ϓ3P/yb<6J X>23XUe~cc#0-M)Yt퉓es/ aqTٹgo>9B("7}C:}|w^$̥N EZD[4?8T_ F s(PGW9S /\ _<;ixt%И> M 3lc<lS,)/B`_=GG)DԻlbN[e4-g Y&,E]i 7w9TOb2p20c([7 Z@ZJ6L./{mfx=2rJ+ ¥xp<<57h6}8ݻ$IG/ [|L4e] X4͈c$0h:HfnlX8\BZj!펠*6=y]Hssz/i@Cd*Ȅ=dH#Kåz:=ƝF?!nr҇Q]_If0_AgGnY[E#`E'^fL4xe4}uYSf|ުu/v؃`xb!xO&j'DQ\ES3sofO:UqRGsۏKqSUSDAvIs~(ʟn1% ԷϚg_[Pxw>~TBSR ų.23 O4LTr܈x2 J'ş`۞wij𱽄"M\"+fƥ} B$P:&̋e XϭH6fNZ"ZMWnTG'_6ND( okb)';}(3&.#şAɰ)MBFe0pVwP75 i 5  j0@370 }i>c{n-ͧ'6t ChCnhz$J^FR%/&lݵΔU^gOI!5,].oL]Cѽ]^Rr,&-5ou$~?D[uc_p)"2uV')%M#2 E,=58ޠ^,}I†R6n{ۏ"46юkhvI, :5O'Ƞ2;n,RNJfZ>^OC/HN0Ӈp>~:=P<?PǾQ'EQѴHUmx~*x0Э/icyNysoEVHM" ZyFFα"H G8Z{~ʘEȲҭ3*: ˇ[uR}E0FzZ"I4D&G^i+(:Cj0@ٶ#>2<.?!jk ѧhIaLOle q6]OwEM æE|IFF_0x.ōbUe)++]nT˸)x~\g03cA1-ʹ:Vɞ;`뮮z2ޠYp7yW;g sail坏q¡F"-&s &דB]c{z@dCV YA4e?U>LCS\m! h+t]4(), &3-\B d1lMfX]>۩8O=>I!i˜?̚SWYaM70vd¾fpCI-9q\`mG+GZlmdQ-COL$>֔ ٌ/@qNHLjxE뽿 j<Ͼv1#H dqym1u(oQ$Ufi o:8 @'&ݡ'0N$2x^vXZKIaY .flv" I{* KK@ FԜ(:y(IDATKqtZݸL2j+@\QAԶ/tn~va몃)agKDa&Fgjaܪ$(0 f bIZ6e9Pc9-,) 2y(ҩ& Oq3.XZBMa0s;>W<- $IM+ f Y?H3Q-li!J<5 Zug. YQhh9!n<FNBGj`iXF`@(jeiHIu(jƉaޱvOS S0,wS5i 鷠Qk[}0ا%NXoY\cux"' xͻUqNv7nk8X{v" s2ɯg]|#,Sp?fW'+'*RA9IENDB`move=1000;blend=1000;1BRW  @ jZj*5KG֪֗j#MiQZZoIGRZ֪֩5֚KTOWZZMiQWZ D!@@H"!! D!@\* fI*$%UUTI$I!BI$B$I%URI$!I$UUI$$!BI%UUUUIB!$HBJI$$$!I$I*I$I$$I$!I$$I$!  oactive siteac1QSx*1binding site for residue po4 a 2001ac3QS\l 1~binding site for residue ca a 3001ac5XZ 1wbinding site for residue mes a 6002ac9.01oactive siteac2QSx*1binding site for residue po4 b 2002ac4QS\l 1~binding site for residue ca b 3002ac6XZ 1binding site for residue ura b 5001ac7RTr*1wbinding site for residue mes b 6001ac813H5Q]M ???M ;` _Z_֡ժ+/ J_iZ֡kOiRUSR?RJU"V UTZB/Bj#խTkR_P_$" H $I?4 WfW#?NNUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QA_ConSurf_DB_pipe[ [ f3H5QB1Y."&"v@{ 8      @ !qBD `(l\0\> &ڥIi&if0"`04Y0*yIc43 &i2P!rDɒ&:L$i"d *Q}@J&P1(0HP 0/ ʂ @QecZ] emYt8E!0>XB L4ag,A'[(<,-46Ӯ,g:6ͬn,ˣAp'uUmm4VmuviieAuW]UK,qZmu:EqQq"B"yAWqWuR(86$Ȇa .(@@ ՙhi5QͲl, Œ,ͺ&&2ꮻY`R]U\q]]uBP`d@ `"lXThhlXhhhhlB4BcBCCBAD􈉅VygDlq$HB ! @dW]U]quQE""AQa:ΪEQUU$H$z6$".8.ӊE$(yccb14"8yg Xd,(E 8Y * eqԈ(e HK,੧UtV(̜)sNg46 A֝uiK=mf]h񱃓Y3M]<,%Dc6Z"x>#"QO"=%]g6lU9Sa6[ifHMs!0X̘C` $(Ux L1P  +*LI4R  1@bp YʰHtP$H3X&Ht\ $Lt鬜gMY8(L T(:Ht 0&"Ax@`L#I&TBy0 s,x^(a0`\3*, Q 2:N8ꪊK2N)ic, j0+0c 0̸c & r̬-n* "8@`8Y<. 8@"P%" dD#āimwQUTUDeRh!H* e5tXQQh L0aJ&iaCL0Ҭ0aUp*aʚ!iT*k2m4SM`ҢM4SYCA[m$*ˮ ygPHƄAƐd11`-M9R 4 2$‡QYY7WD: 㫮Dhi[YfVYmq%YB@ @Xc 2iSM0k, g…XPҦa2LE a3mSM5 ,MmwY8mf8Y\|MeMfefe] VHE%Z@bbGh00D ' TN `10"b`-TM6V16Y8OQF 2q̚-'&rɲ+&TM 1`QS9Md# -6Mm:,NۮӋ% "6&$I$(xB HpB`-@ZiÓa7]qUV( T&ȘAةEYUHmfUu6T131eCaTQeʌTQFXM4M5qaFTa61 †0 (24*@6 [mmg]wU @B ]t]uu$RuH96E0 $k(a blTuVQ a3ef]fpG8]TIU%Q@T#(Ppt8Dmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???||$??@ oD ED@?^;?^;?^;??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 2)/PNG  IHDRc IDATxwŝ?3;VZI9#@$`dt~}<ϯ}9ޗ>al1p" %B(K*9twGul f'tWU|WU(91X:"P WqNǍ6m c69X2g=RIJۉa;ql7J~|t< g$nۉ-@d#ŜXf)]\icĝR:3!1v&:vL 8G Ջ Ya8&nG'{hy&fM[ 8NE*9a`fM[.R{Xg̨^TJ卵8thās7L<(G*I[[=yӪ!Rgi|#by8&RH8C3FR9 u<38pq_8G,0bB$HzS&MiE '޶i"0ȱ))@I"Ru3gy4w4rşҢI(ϏF*zk䦃gy.ͺ`jR{9`ҫ(.D)?m{`5ƬQ!̬).Ћ])q\u&4qfN[J{W#X7RncYCpTҋnW:(r8vƺhj?Ao $7n}VGydFfҧS'UJ(x!+u?9]k^)1P_Aۚ\!~&Oۤ+jQ,3LIA}VHR pሯ+ gq@=48}.>ojg y\R `ya)ӜΈÔYxz`Wb7h8A_\Q黶zCd|i+&񉽫 VSIkC^Ts% .`EeW)0L G<;6FW說q?GOq.&gV/Vʋ/ȓO>9\6gW~Ǻo5w?yꩧ6mD$ hhh'?I50m$.n μj1y_^]s59x?ʊ =mUÞ3o<&8 ǵqgMo[o5 BσPa)0!!|q뻼ZMܭBỊCBIMg/&.V qƥ_H_P&͛G+@p~l#:0U󎰲L) yWNUVEgۉ{y\zdӗiWԝ؝V_lH}aӦDq1FCR-3L P31 +8o47#YKhP䅆 skWy++%9D:[Vz&H2_> |16" ljc{㾄00Ms{=|;k_ڨ1 HH! zېJd6=_ L*>|cWn6uO_K f͂~! !"F~ }6qGai M`:LK"2W$JĔgpG~;_~9K/ ϧ^D  aNغ5Դ%̧tP>ȈӾs=Þ|_q@\ziZcabI@;F]vQs[ ozkɳuVmӑ< <~b̸kG/sG"W7㸟>ݓOŠp%44஺=K PB $ yYv-RVVFqq1EEESPPpRRXI'IL*&MWeUzga2֞%^ "Ū R KTyIuNV>6nܨVZ56lPoP[@vsVF P ꅒgx" p(¡ Yy{wuU p(KUUyg:t^ b!C MMRI\zzb Wo_?Oy;wOX62g?xΎG?wvɓG<>?j,d奬#km7P>JIL6":Vb;F"^2Ԭv&1 W`n!D;֯_֭[Gt Hj?<_{ӫSL|]fG0%C¡kiشNK0݂C#I{.7w$ v'Se+H~>Hnk}q8~,WG|͓ jD$k֬(F~p(rI_"?\H^(iCO#ÑIeޮ21mBP[ fKJ^pBdUㅾ>\`pWCKpoK)˿/1 LaLg)Jo@7NaA)E؎Mot)[(?߰tH dJqt;]ưI~af{3n Gcs'N@IrI*F\t]׵*;#0RTN0s|n *\}-y^o /, Ώnɗ)|A^~sJP 7:XR 0 s.0Ro?Baw~\KB|sXO6~5N+P X2g};,^}Cx|sKK~Q/}KYIE+ʵe4tPQ2ֲ*v_OJzf].υ#ΓTNf|7ȪmW]uͅ^{-v}Y^{5\% q͞=h{y)v.\zUZ7)`m]okk3Vbeic#+u/p0UA͔yM~rĝ>%Ѧ'.PPXfHK)]#ʼntB0'MdoC)E{W#e%Sv̭Y (^=0?W87sߟPrx/NM瓗G4e˖-|3[oݩfSZZtthZL_!{^a돍='T7J X(L3+N9PUVlH2"(&:ib)Y8L_R{F49pCKE}믿>'?Yja0sLyO*NEyiɦܰTVONvwEkRV@a~ʲi(f|ok+bMIj<5:ߢx ^g^ i U4y:{Zv.$5G.q ;v < +(/D$/B[{+]=+"d"k@XKR{6muגC70![)>[W)V.؈T]N`}AW -P%>s 7-]vY2[K[.'MTCqq -teh+hN-C/r I*NYJtE |_=p뭷ۿ/[no6kG޶g;h , WcP_)$Ä~_x}֭lݺM6qmkTБ׵_6{rföcF;i89skWGY})B_H~2% ivh7=́jZUv P_B̬ǯy'8r0?x`ݧ͛q]f…q 1l; gSB'6nqbNc?Ŷc(*BT2ޱh*yM•.]4Cq=}ym ?=w2R."/{=LC/--hꋵWA*( ~lDUd}6<,+D a'ımMX_8yGGc&>܂tv7g%?ljd!NG<[Fn/ZW `ϛo?oƱGm\;}²B0vI>:pS3SVQJqy7S%)/.X/u'`ׁ"YkVʱ9xhb3g._#j+Ǟ[wimɳxZ>[8|0S0ca;2N r2[hN lj#б<^ L D# ZͩYAWO+up>/]ͯm;zya uu:@#'Auu=\\# ge.\Fqӧ/|wM5'}&@Ԏ-l:ۊDuƋ6+.V׳n:,YɓId;_d] 5vz |o>%#h!͹ҹVk?x R1+92xGydP_ҧswf{u]|Mv=xivbv/fry- >NJ6cj}k,ۍYsݻ}񱏍l:OQQ:׵kWL4_1 +̩Ye6K4rT?ٜj92:+nGyys?1~1駵㤎 ~S|S}Ims(Rj>!M ^B(A{ ~+ӭ頹][7L?$9X z:ٕ` l:+;A3ս8~&㥗/E)B\,m5M ێrѪN²bBdLtX'fL]LUY ]uaJMZX"/OGwӈ#(OHߞD]"+k% ai3×]WA[dMa&Eo+$G t_Ht1@ Aʾ_yy ~A'UR^_&Ik?>嵄ޏFq:*bw9tPA,Ia~)ϽPM&$P)N;UfRT/_w x㉪Z"y߲^BB xp4nEJICCr 7 k SD]13f^B79D][w/N+ՕJfzM絝(}^5Cos,JIl[Ovq`Oi'fob3DI1dtpKOc_ NiqL\L* r,i>U0WLLL-i_p!/ T5`xH) 3[$R i$􏿨}}FHGRNdUNb"jI8 b#s)]aNYxRG0Ԑkq@!7Ue5~IDATKkWD Ӵį*TG:i.]}s5v_ttՅLrP:Ck7EaA)~ta~8ɹS_|݉7iKŝ7~R,%E:A`hI~Ϛ dL>k] ?9jb_6VߑVJ vZ;[@$ռ%T)WRH^V_ܼA}$X>b7x~ݩ)D&OMBP tI NY^[zui{ [-yr)R!̓G-"H=G]=FSom_$4L~ f^08^Zo޶d' "fyYmB0bHN3{rvWOspĎ%L2[2r9l6K*6})Nyumz]D.ʙAi-Zeh{BʹX4{ {lv@M>7919sA֣Jxo>?RӒ+uW::rgǛ2jN@䆖W-f6=}f7FFFPJX'1}|=~ -݇Z9m)OR_8ePbN6^p.74S|݋o\yR'6Rcjև/}Pr弶@z뺿/,q~I283 | D""ib9!1- CX]o<@A{BlعgˠUOE܉/# 񝖔7W\F@.ہ+]^Ǻv8¸lEbéK`FP*{#DMI9u i.V(8Xm<飄ުwx) 4iL# 錜#@8 +߃iw7~upIy%8I$˯O&R͇Ŋ,?>9Кv8IHRJ\u\G(dY8V˲1-e{?ӂei˴LSɺj>^4?R/e݊w81z:+m޺m(>:h MmǂKdK/70j. p<Ҹ븘xa@8vjoC1M21-ߣq8oƔ̛ۉvۉzxk]KI'02eŰ8NK+E4PJrP,wq.vSS)7ؕՠ`}wճƑEjutS[z8qab St ! 6ܬ+4L %~?aS =@⢃R9B3)SW݉78vj/'rs0Rjj  qOfR4EX:wC>VI /,QW9?|ɣ47pN{ۇݬ iYGʕ.jWǵ8N['E`[džf@vKmZ$hno܉HnB-zsXKz2JmL4?ggXw=8pPpUԕ-Ҏ爻1l7+`ӧdzP2AB)@bcpl8|8@@+B1lzFrGO f^@܎& oΩzT̶1]g?WIoRL*_aےΆjۺfv;P(ZQ[?zP$IrݖAaP#~ t]A[mu߁iUtZ<'1j.Or4xz!҉mތITԴ8GHT$zӔ<3.` \lL3H%(EeyM@2Y৻5j.ks3^DfnaY!\ɉ I<ɍYdcR* CR_R m:԰1t:tJɦCھiZm헔-x `  HTBd8mPRJJ&dʤYԟz]^ Mx&O G:ųH%5mx:RLIfmlMLE)I(u^4M iھiv?J k+3;IENDB`move=1000;blend=1000;1BRW  @ jZj*5KG֪֗j#MiQZZoIGRZ֪֩5֚KTOWZZMiQWZ D!@@H"!! D!@\* fI*$%UUTI$I!BI$B$I%URI$!I$UUI$$!BI%UUUUIB!$HBJI$$$!I$I*I$I$$I$!I$$I$!  oactive siteac1QSx*1binding site for residue po4 a 2001ac3QS\l 1~binding site for residue ca a 3001ac5XZ 1wbinding site for residue mes a 6002ac9.01oactive siteac2QSx*1binding site for residue po4 b 2002ac4QS\l 1~binding site for residue ca b 3002ac6XZ 1binding site for residue ura b 5001ac7RTr*1wbinding site for residue mes b 6001ac813H5QTM ?MUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUP;Y ֢ZZMjZZjT/֫OKUZ__ZQ$Jd))Z_)L! f4 WWf#UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@ ~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QA_ConSurf_DB_pipe[ [ f3H5QB1Y."&"v@{ 8      @ !qBD `(l\0\> &ڥIi&if0"`04Y0*yIc43 &i2P!rDɒ&:L$i"d *Q}@J&P1(0HP 0/ ʂ @QecZ] emYt8E!0>XB L4ag,A'[(<,-46Ӯ,g:6ͬn,ˣAp'uUmm4VmuviieAuW]UK,qZmu:EqQq"B"yAWqWuR(86$Ȇa .(@@ ՙhi5QͲl, Œ,ͺ&&2ꮻY`R]U\q]]uBP`d@ `"lXThhlXhhhhlB4BcBCCBAD􈉅VygDlq$HB ! @dW]U]quQE""AQa:ΪEQUU$H$z6$".8.ӊE$(yccb14"8yg Xd,(E 8Y * eqԈ(e HK,੧UtV(̜)sNg46 A֝uiK=mf]h񱃓Y3M]<,%Dc6Z"x>#"QO"=%]g6lU9Sa6[ifHMs!0X̘C` $(Ux L1P  +*LI4R  1@bp YʰHtP$H3X&Ht\ $Lt鬜gMY8(L T(:Ht 0&"Ax@`L#I&TBy0 s,x^(a0`\3*, Q 2:N8ꪊK2N)ic, j0+0c 0̸c & r̬-n* "8@`8Y<. 8@"P%" dD#āimwQUTUDeRh!H* e5tXQQh L0aJ&iaCL0Ҭ0aUp*aʚ!iT*k2m4SM`ҢM4SYCA[m$*ˮ ygPHƄAƐd11`-M9R 4 2$‡QYY7WD: 㫮Dhi[YfVYmq%YB@ @Xc 2iSM0k, g…XPҦa2LE a3mSM5 ,MmwY8mf8Y\|MeMfefe] VHE%Z@bbGh00D ' TN `10"b`-TM6V16Y8OQF 2q̚-'&rɲ+&TM 1`QS9Md# -6Mm:,NۮӋ% "6&$I$(xB HpB`-@ZiÓa7]qUV( T&ȘAةEYUHmfUu6T131eCaTQeʌTQFXM4M5qaFTa61 †0 (24*@6 [mmg]wU @B ]t]uu$RuH96E0 $k(a blTuVQ a3ef]fpG8]TIU%Q@T#(Ppt8Dmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???<4$??V>V @{t8@? ? ? ??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 3xFPNG  IHDRc IDATxw3s]Y齃`WkT4FcI4yvSDAuanLL }J(4UPU=6c`"LSfoG{8t:Y 2'⦱;!Hon/G(i`:iU$4 KG PR3L4ihZ6 a$ d4 /B#QUaζg(ps7Bu=&^νQU}^2suhGP!8>vƋ CGǥT 0@ @ ]Zxi2^};G(>ud@pq1~%=K0;yc3OhQֵ_:g<6L9yk=;{ )f))ciK]k`2b;a iOگoa 5 iԍ00 9 4O"τ-]by ;[ GTf񔕎_V~'<{+63jXEBE%G{Z0MŠ3g!FɹQzÈŅG|B.cj  ӯh(RuKMUQQZD|, D(IeW;1aX[NPyl?#gİ|_vKg^ix\>Su=OZڣ aC7b膎nĘ>/R²EL#DcaEeᴵx\><.l}^xA8ѰcF%X6TEEQTq[ \MuɱP0LW"TŻ=n`7x'j߽GUT 1pcS8Xq.-v}æ9zuЁc~,q}L77?μs𸽸]^@} O0B>;:!.GO&8π=o.\.-.̓f̞|ǯdeo>*O^OU^ҤWa:'(hBЍ)-~CQT^fM:SSqK=B7uG_8u-O.GPSACshnM` |r:~AIv?dτ, λ ٹ@be<¤:xkbͲ%nmq14n!u@{fMэc\f Ӳ,Kz =y'+}$zL,aΒBr݋>)i̹϶~"iF4i1+\S uM@kJV]&}.~o.KI>{B~%8e!_YvN346WGl^8uI Uąlp醎aJiT&8{p{wW硪ȞMLv~xZ2B̈́A&TUs~tS֠2( X!LF̨aS}C+ [h%ŎlY~U97YJS'3u2>brʯ1v,0Z:MCQ[lbofF ;^]8Q4k nh>txJOWRNd4h ֧ٿУgIaϺԑh,D4!m%*j[9iDHA8ߗscIM)vWl9*L)+)O~錋0M?>?wmI$뫮4u^}ͼ=zsӾ%g;NfTCq$;+i2f1>u#Yr2B9 Ŕ1 VS~錋D"|r4ͅPۗ2Y:7'y+nFQT4 ́ZkjyiýQF 䌵hZg9Q'2My )܉Bx=Oޚݥߞ4[ݎ~Gl$+Tc/<'9T:ݙBE M_)L|"ѐTnlĥT{*.vw8[1g ǎ| !hΤ3°\a?$ Wcrv4WqGx*` PU 9Rozcht[xƕAryBM;SwҎ|e"X=i|{=¥ isd ǟlv9LRbmkȞLӠMuRU-!RE<ܫ[MaZux=Yy $ o-@?Sf* 5";^@QU*hjs ;6:>o6BtWQ9_fiWe(Zn+ƗA7ud.4˳ÿN-SZz㝐ǥq%vYRT +S?t'lTWrAǷ+8tS0[IX?N,DrF*HH|HZ α7S?y-K%]Mτ#KNN7PAṂ8EyBdk ESo*864{.;ǐ֨DQ!!es%t1 +'ʐ\Fv?i=xfbdSߞq?~jURQ);+ RTTڵk {}|Mu0s©IETXP,00+1Gz1gl?=q9NIb#%&`ZλOKXqUW?y`.]ŋY`AT5&n}*y0W`0-އRVR,[^cPTKssW֯h.Y߮j44I#믿_~f?|;n?{ҙEZ[A>L,g*1=B(¦/k%RVR.+7ǍͨaSW8H,iU(KȜ!UCS]4/4qM7~iN?N3, q)$;~CYU5\;~5_i P =̉[3tkkǾ }d)*ԭA4MLU&$/o~DQ~^4//w?e50'?9 MQ2ϑL^= ef1px>̧#D SY'bN}9Y|m8H}^o6W):1[2A1bzV"'{ | _u綾RFjx$|IgƦ1ig:O&)Złr;l4*E⅚hhCp4@q ^t=Y<FZ?ފx> (`FSVcU dƦX12;?.|NPYiſlAIyю<Վ(%c- t,Ry.%w* ]7Ʋv,ax%ה{x r'u_.W\WO,#5=9Q=}Oߞ4f3v, 1L>JeOYM0B8  [p 7bs_v,5!AݡM]@Q$w|xb֬Yu]-8fʮ8ِ`>ıI׫*qs~ۇ)D^# H(2,6ɭИ&/ls13^+õaY2VϱtR.N[^%-˝T:]$7`qqTUުʟ~f9m5ʐ*~cIN 6}'v}u-h_i UA~YMUP̽|Qp4@s.LIxH\qYlRǹBuIݻ3޶( jp'KxY d ;ɉxMsYo<'%ɑH0 IlƖjS1sf){ ]P(2.i9PG]V!y9{ 73M7#mq?*qݸ\.4Mcm̟Gѿ0CF0V [3c©4ꜶxX6sI{UUEwp_&qA+T剤L92ܛdž33)qY`, bl  ӣI|8EaG5͘QJUUrA}G\e%'%_@~vZ%ץ'//< [\)LnZJ$l\B`綉 L[BKX^mP繬Ss'Q~k;k@vTx=Y7^{r`"x" nCAi<GS]Ė-]a9n<@h eT<¹S\\‘+Y݅`)t} ۤ~'_Ģir%yMpmsڂ+l/9i H0 iEm/BUT;kGflaҤlz 6HDR{-TNIk*Xǝb1=Svx)_mlX&%w5*9$Զ8}5 OvoٕJy\EmQƌf=68Ixws뢋.b8$s~ q ۏZKcs h/`@#BU4L8naQP;C!5V(UO?ܬ"| p3;eFffELektP.4[ٙm_@۞˖-#S[[K +,a_GX5iȱ=eIZ퐀i+*y9i[!a0&N2zbsVu?ilᓃ#`s#zh4L$L f6eG]c|NDquIÔ k~Ù6m/2o&1]^\H֭wgp$@u!gdJxհgϒB4/޺u0N[&،a{o4ƿ%)M5D0hH4dI!:gqVW]qk+a+D<ϻX..ELO7LQ.[wI< DkGo:7M$1=X]ĉض(r6زuZ$w_!uXT'ӉEu~SJ|7fwZ y>_9hku7xݺՍm]]rMKZ/X0ֈcU陈^)7:p,} үp>OOБGa^yhơSI`:#[ّ6>'s(Db!̘90A,cxᢸ݌+XCvyQl5wç3K6n2?X O({`ѢQ^%'ke% 7A}G`Gzx:ݯ0?Y<4šI'n㤡Ѝe%7>|,#R^v3b|G;%7ZdZ!í",V/s]wuz&OơC ;L8Q!љ7o$no~ٯҁQUKʸ&< ǐ"?q~Q<4Us' 4݈"I""d#)kϙ 2$u8 nNB~[k9}V1cF)7PYp`mOJ,fys~^gKaɫS{ E梶#]h*/>}3LG]hxsBQ߹݈Y;KMC' mL̄U^c$v&< UW@/OZkvWz;_rټy3O? d~xt/bfj6lϮ]U[׾W˅Ncݺ9V(SOw m#te%wH4~̞={SGܜ,vq7lΝU\qŜپ(nR6px\-Y;K svEfg69Pb~"E{+ҹȑ&>$ػ0p]ޤ&<`@$UV \*ެ^6,S!PPvg9lhЯPz[jc^/Kx G/LÇk';&cx>9.V"Zkˁm <#Ɨe7BDsqMinnU*/@0܌ISK %08 >.z'!LSˆ[5gRt<=8lvES/ Q_]Kt:S {kFVVlٲ-[v_Fѣp%|X>R,ӮnyO0O^M(HEQØ3xfIqĩ@V!Re˖1uT~x^Jxx<\f8TXygvbRd,<,>zŧ~ާ:Iā6 &_W~Ns֪.Ec6SwĈGn_hlccp0\y܎;8}RPT@Xe;#5?e`E%j+Ss~ _ q۳Rlj!nf134o4)Stq̮!_ps ">;pYYgüރJo֡γv-3H4L0DEBa/tx4muCvR3:Ȓr@Œ7(Ͽ'sf# N쓟Jٶ]ҋ/Ȋ+t5;ًϯSBMQ'_7b<-B(f[?Y??xwd'%wfte%唕b3&&zׂhj!ip$cYr+H]g "jM93EQqӾEAn?BVJ )\+IpTME4nB^A4waDsk-hZ&t#2fy яӛ8N.d9Z[I%֖s鷓/ nei}6^{A\ ͥ9\^azsY|`#́zNetbp=;wNG[;NXvu$R(BcK?&Qv 篸Qk9~_\Lat>!N D[*vW]'"MG;,LYvi.YG(L?-$qڧ-̙|x{%kurZ|M*@=kiqS4 Ǐ?G7̈́O($j@v|zxΒS=}d0LvKs« lN2w\.r^@G>#?fՔuN$w(vY[~39Y(@ L}S+?bϡ9W/ YAFQVRʹ,/!w=yw_BB+k6{P>s?ϐ!CdɀuC)WQ:Gٴh 6R]c2n>k IM54PJO]B8Q?ۏߗ˾]79JY1[N4ݏ]q,[M66$㮇"p WdQˁo%\{̙3RϨ.wYplg+G[(*H+p 5TeUnFC[Zv%$)&SC_N)ϓϛ#Ga OدuiLoc=N뮻hhhFw_رqƥ~1| [c4ldEDb!XC>-ˋaD-^@:uig*eؠ ;\@IZ~o^]+JY>R!c=oAwoo='ώn ; )bsNƎӡm@A5VrrGOG-nhi:\ktKsy}pin\./!@f&k z{9>,zj?_zx)(m<3vi͛ yR'+;iϟCWs>_~n|%QM`ue"T/4ٓ"n4y}p{S0lnIK&~ SEQph ˍhISݹ&3_=de)֭[=d6 ̙ 7O 1Ӝ~Lq<$".@9]æi 6 M_ӌ'$O\@ᲒrGEI _f͚Yg4 ,gڸ#AkvQV?-4xCUd}l])NC(`m{L :}:m:6 IaJ ЕF Swwz+~4xaժU\~d[AB7݈nG}"W';u)x>MGXx-j]۲rF)ɒms+O$?#Lx2/<h 5và_8G^x!/v+@`/r{Fͧ /iZRKS] w^>j'I(+)gdr-1-](a*7 /3l䓚`'(=ŁPiNpDF\Ξ=  ʹW0xz2漟_oaԵ(BKk->~g<(Yâ뮣3'z…gR?Èi8ѯ 5L%fxN`Gy{˓Imm}ƋuG>B $!/GB&h0SMjMHOEG^)Gk.@ƏnBgo%N;a+X& :Muߡ('Y*4e}ЏgXy58;|eYWMm ;ypRzܲ {xݲ=% ֮voNeӜYfNA :f95I]gVι¢ 6\i"Jl0cN LSK55 3j2BR&GBq۳Y={򙜷'@væƹ;pyE$wEkwkNQ5$f")S.|MX|M:`,+^)g9k6n 6z TM-hAQ0tɈEZwxktƕ"r,11M˂0{aX;ކm:WֻmΰAR9T7v :Bg ˗(N ām|#u𙬘uiR2ׯ;u"htFحag6ɡ 0 "jEsWSV6|3'9K[ Vl!D-Vngq3LEHRK,_^ E)gÈMGo3W4͸n%1h*" 0b\: )L۞a̟76u/Y0m p3mdж‘=EbI"Xp S`ׁV3.vB1 4T;6ZI6:4Aڒ 7REyِ\fӰKǞڗ̸W7vgpw` fIߞCRVR+%Os0Mr$D/nONdVVq^OSc&D[ rRUwݚ6δjz(8>0oS2tjnv{~]*>fOWފ4PPAma]e#LӪM㇎,.:Bz~{=׬Wn{+65ZrSUuI3pPYI9EhhlҞuVlnw 'oryT-\O^«'IDATdra4OcelefO>#fuBCsE F 8O"cCg7`+Q59|y PCsgFh@j:UvO>Vw7h,d9[(OnVePߑTu.(̓ݎ]k giLa"鸀O}j@S5i[NϢo.vn&}wSz1XJ<./;ӇGꑮ @0$yW3LW&.̓a&?E#/1H*ke&gP!y3 WXWg g:*}S5-nY\ϴ$BXs>֗hYU#”r3&G1 >i] ƩVLfO:3-g-zitL PQހv)΅gCČ1#aFeQS)Ean?ICs_79Nހ# 7QOL況vcWpz1RP(8Z@ףNQ z\]:vL]Danܚor/wϗuX..:?Gxk #= (#<>OŰʂ%Qb SWʓG=l_>9Y0w >o6x:ATPQ-*ON8A}G͕xA@AN?Yc[xtޛF'/'븱gPI}JS CVe& {5drcP2r ͖r}.v;#Ex-CQdзIM!/>vw0fL s3( ru)U6̭R@<.} Q\0{v3z$oaC;i|NIo3|$sݣ>xRpifiČ(=<[ZiMCmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk13H5QA_ConSurf_DB_pipe[ [ f3H5QB1Y."&"v@{ 8      @ !qBD `(l\0\> &ڥIi&if0"`04Y0*yIc43 &i2P!rDɒ&:L$i"d *Q}@J&P1(0HP 0/ ʂ @QecZ] emYt8E!0>XB L4ag,A'[(<,-46Ӯ,g:6ͬn,ˣAp'uUmm4VmuviieAuW]UK,qZmu:EqQq"B"yAWqWuR(86$Ȇa .(@@ ՙhi5QͲl, Œ,ͺ&&2ꮻY`R]U\q]]uBP`d@ `"lXThhlXhhhhlB4BcBCCBAD􈉅VygDlq$HB ! @dW]U]quQE""AQa:ΪEQUU$H$z6$".8.ӊE$(yccb14"8yg Xd,(E 8Y * eqԈ(e HK,੧UtV(̜)sNg46 A֝uiK=mf]h񱃓Y3M]<,%Dc6Z"x>#"QO"=%]g6lU9Sa6[ifHMs!0X̘C` $(Ux L1P  +*LI4R  1@bp YʰHtP$H3X&Ht\ $Lt鬜gMY8(L T(:Ht 0&"Ax@`L#I&TBy0 s,x^(a0`\3*, Q 2:N8ꪊK2N)ic, j0+0c 0̸c & r̬-n* "8@`8Y<. 8@"P%" dD#āimwQUTUDeRh!H* e5tXQQh L0aJ&iaCL0Ҭ0aUp*aʚ!iT*k2m4SM`ҢM4SYCA[m$*ˮ ygPHƄAƐd11`-M9R 4 2$‡QYY7WD: 㫮Dhi[YfVYmq%YB@ @Xc 2iSM0k, g…XPҦa2LE a3mSM5 ,MmwY8mf8Y\|MeMfefe] VHE%Z@bbGh00D ' TN `10"b`-TM6V16Y8OQF 2q̚-'&rɲ+&TM 1`QS9Md# -6Mm:,NۮӋ% "6&$I$(xB HpB`-@ZiÓa7]qUV( T&ȘAةEYUHmfUu6T131eCaTQeʌTQFXM4M5qaFTa61 †0 (24*@6 [mmg]wU @B ]t]uu$RuH96E0 $k(a blTuVQ a3ef]fpG8]TIU%Q@T#(Ppt8Dmse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1~binding site for residue thm a 434ac1 1vbinding site for residue so4 a 435ac2 1vbinding site for residue so4 a 436ac3_o1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES..1met->mse selenomethionine MOD_RES551met->mse selenomethionine MOD_RES??1met->mse selenomethionine MOD_RESAA1met->mse selenomethionine MOD_RESGG1met->mse selenomethionine MOD_RESpp1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RES1met->mse selenomethionine MOD_RESjj1met->mse selenomethionine MOD_RESkk1?333333?333333?333333???????@???SNAMRMIDIIEKKRDGHTLTTEEINFFIGGYVKGDIPDYQASSLAMAIYFQDMNDDERVALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITEjpyrimidine-nucleoside phosphorylase; chain: a; synonym: pynp; ec: 2.4.2.2; engineered: yes; mutation: yes_HHHHHHHHHHHHH______HHHHHHHHHHHHH____HHHHHHHHHHHHHH___HHHHHHHHHHHHGG_____________EEEEE_______HHHHHHHHHHHG___EEEE__________HHHHHGG_________HHHHHHHHH___EEEE_______HHHHHHHHHHGG______HHHHHHHHHHHHHH____EEEEEEEE_____B__HHHHHHHHHHHHHHHHHH___EEEEEEE_______EEE___HHHHHHHHHG____HHHHHHHHHHHHHHHHH______HHHHHHHHHHHHH__HHHHHHHHHHHHG___GHHHH_GGG_____EEEEEB____EEE__B_HHHHHHHHIIIII_____________EEEE______EE____B_EEEEE_____HHHHHHHHGGB_EE________B_EEE_____p_p_______________________________________p______p_________p_p_____p_______________________F_______________FpF_________F____________________________________________F__F___________F__F_p_F___________________Fp____________p___________p_____p_____F___________________FFF___________p_______________________________________________________________________________pp_________________________________________________________________________#binding site for residue thm a 434ac10F#binding site for residue thm a 434ac1F#binding site for residue so4 a 435  ac2F#binding site for residue so4 a 436_oq{ac3F=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine ..MOD_RESp=met->mse selenomethionine 55MOD_RESp=met->mse selenomethionine ??MOD_RESp=met->mse selenomethionine AAMOD_RESp=met->mse selenomethionine GGMOD_RESp=met->mse selenomethionine ppMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine jjMOD_RESp=met->mse selenomethionine kkMOD_RESpMRMVDLIAKKRDGKALTKEEIEWIVRGYTNGDIPDYQMSALAMAIYFRGMTEEETAALTMAMVQSGEMLDLSSIRGVKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGTIDKLESVPGFHVEISKDEFIRLVNENGIAIIGQTGDLTPADKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKKLDEARRLARVMVDIGKRVGRRTMAVISDMSQPLGYAVGNALEVKEAIETLKGNGPHDLTELCLTLGSHMVYLAEKAPSLDEARRLLEEAIRSGAAIAAFKTFLAAQGGDASVVDDLDKLPKAAYTSTVTAAADGYVAEMAADDIGTAAMWLGAGRAKKEDVIDLAVGIVLHKKIGDRVQKGEALATIHSNRPDVLDVKEKIEAAIRLSPQPVARPPLIYETIVWprotein (pyrimidine nucleoside phosphorylase); chain: a, b; synonym: pynp; ec: 2.4.2.2__HHHHHHHHH______HHHHHHHHHHHHH____HHHHHHHHHHHHHH___HHHHHHHHHHHHH______________EEEEE_______HHHHHHHHHHHH___EEEEE_________HHHHHHH_________HHHHHHHHHHH_EEEEE______HHHHHHHHHHHHH_____HHHHHHHHHHHHHHH___EEEEEEEE________HHHHHHHHHHHHHHHHHH__EEEEEEEE___________HHHHHHHHHHH_____HHHHHHHHHHHHHHHHH______HHHHHHHHHHHHHH_HHHHHHHHHHHHH___GGG___GGG_____EEEEEE_____EEEEE_HHHHHHHHHHH_______________EEEE____________EEEEEEE_____HHHHHHHH__EEEE_________EEEEE______________________________________________F_FF_______________________________F_F____F_F_F_______________F_F_________F____________________________________________F__F_____________FF___F____________________________F__________________________F__F________F__________________________________________________________________________________________________________________________________________________________________________________ active siteQSlnac10F active sitexac10F active siteac1F$binding site for residue po4 a 2001QSac3 F$binding site for residue po4 a 2001\lnxac3F#binding site for residue ca a 3001XZac50F#binding site for residue ca a 3001ac5F$binding site for residue mes a 6002.01ac9F3H5Q_a1BRW_a  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~@E0K;?Qjpyrimidine-nucleoside phosphorylase; chain: a; synonym: pynp; ec: 2.4.2.2; engineered: yes; mutation: yes3H5Q3h5qP 1 2 1BN]/B#=B'???a???@Y˥S? AHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWMaa3H5Q_aali_out                  ffffffffBffffffffffffff fffffffff ffffffffffffffffffB ffffffffffffff fffffffff fffffff Bffffffffffffff ffff , fffffffffffffff ffffff fff ffffB ffffffff ffsMtMuMvMaathmW] [indexXthm thymidineaaso4sd lines aaso42sawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253awa254awa255awa256awa257awa258awa259awa260awa261awa262awa263awa264awa265awa266awa267awa268awa269awa270awa271awa272awa273awa274awa275awa276awa277awa278awa279awa280awa281awa282awa283awa284awa285awa286awa287awa288awa289awa290awa291awa292awa293awa294awa295awa296awa297awa298awa299awa300awa301awa302awa303awa304awa305awa306awa307awa308awa309awa310awa311awa312awa313awa314awa315awa316awa317awa318awa319awa320awa321awa322awa323awa324awa325awa326awa327awa328awa329awa330awa331awa332awa333awa334awa335awa336awa337awa338awa339awa340awa341awa342awa343awa344awa345awa346awa347awa348awa349awa350awa351awa352awa353awa354awa355awa356awa357awa358awa359awa360awa361awa362awa363awa364awa365awa366awa367awa368awa369awa370awa371awa372awa373awa374awa375awa376awa377awa378awa379awa380awa381awa382awa383awa384awa385awa386awa387awa388awa389awa390awa391awa392awa393awa394awa395awa396awa397awa398awa399awa400awa401awa402awa403awa404awa405awa406 _ser  Hasn    Hala  Hmse Harg & ! "!#"$%##' Hmse'&(*.')('+*,+-,/ Hile(/.026/10/3425237 Hasp0768:>7987;:<=;;? Hile8?>@BF?A@?CDBEBCG Hile@GFHJNGIHGKLJMJKO Hglu HONPRWOQPOSRTSUVTTX  Hlys PXWY[`XZYX\[]\^]_^a  Hlys Ya`bdiacbaedfegfhgj  Harg bjikmtjlkjnmonpoqprsqqu  _aspkutvx|uwvuyxz{yy}  _glyv}|~}~ _his ~ _thr _leu _thr Hthr Hglu  Hglu  Hile Hasn Hphe  Hphe  Hile Hgly Hgly Htyr  Hval Hlys       _gly       _asp ! _ile " _pro %!#& "! $#%$'# Hasp!'&(*.')('+*,-++/$ Htyr (/.02:/10/3245363748586798;% Hgln 0;:<>C;=<;?>@?AB@@D& Hala <DCEGHDFEDI' Hser EIHJLNIKJIMLO( Hser JONPRTOQPOSRU) HleuPUTVX\UWVUYXZ[YY]* Hala V]\^`a]_^]b+ Hmse^baceibdcbfegfhgj, Hala cjikmnjlkjo- Hilekonprvoqpostrursw. Htyr pwvxzwyxw{z|}{~{|}~/ Hphe x0 Hgln 1 _asp2 _mse3 _asn4 Hasp5 Hasp6 Hglu 7 Harg 8 Hval9 Hala : Hleu; Hthr< Hmse = Hala > Hmse? Hval        @ Gasn A Gser B _gly !C _asp! "$(!#"!%$&'%%)D _mse")(*,0)+*)-,.-/.1E _ile*1024813215647459F _asp298:<@9;:9=<>?==AG _leu:A@BDHACBAEDFGEEIH _ser BIHJLNIKJIMLOI _aspJONPRVOQPOSRTUSSWJ _ilePWVXZ^WYXW[\Z]Z[_K _lys X_^`bg_a`_cbdcedfehL _gly`hgikhjilM _valilkmorlnmlpqoosN _lys msrtv{sutswvxwyxzy|O Evalt|{}|~}|P Easp}Q Elys R Ehis S Eser T _thrU _glyV _glyW _valX _glyY _aspZ _thr[ Hthr\ Hthr] Hleu^ Hval_ Hleu` Hala a Hprob Hleuc Hval       d Hala     e Hala f Gvalg _asp!% "!#$""&h _val&%'),&('&*+))-i _pro'-2,.03-/.-102,14j Eval.4357:46548977;k Eala 5;:<>?;=<;@l Elys <@?ACH@BA@DCEDFEGFIm EmseAIHJLPIKJIMLNMONQn _ser JQPRTVQSRQUTWo _glyRWVXZWYX[p _arg X[Z\^e[]\[_^`_a`bacdbbfq _gly\fegifhgjr _leugjikmqjlkjnmopnnrs _glykrqsurtsvt _his svuwyvxwvzy{|z}z~{~|}u _thrwv _glyw _glyx Hthry Hilez Hasp{ Hlys | Hleu} Gglu ~ Gala  _ile _asp _gly _phe  _his  _val _glu  _ile _asp         Hglu   Hala  Hthr" !# Hphe #"$&-#%$#'&()'*'+(,),*+. Hval$.-/14.0/.23115 Hlys /5468=576598:9;:<;> Hleu6>=?AE>@?>BACDBBF Hval?FEGILFHGFJKIIM HasnGMLNPTMONMQPRSQQU _glu NUTVX]UWVUYXZY[\ZZ_ _asn V^_]`b]`cj^_a`^d_ebfhcgidedek _lys `kjlnskmlkonpoqprqt Evalltsuwztvutxyww{ Eala u{z|~{}|{ Eval| Eval _gly _gln  _ser  _gly _asn _leu _thr Hpro Hala  Hasp Hlys  Hlys  Hleu Htyr  Hala  Hleu Harg          Gasp  Gval _thr #!"  $ _gly$#%'$&%( _thr%(')+.(*)(,-++/ _val)/.025/10/34226 _asn06579=6876:9;<::> _ser 7>=?AC>@?>BAD Hile?DCEGKDFEDHIGJGHL HproELQKMORLNMLPOQKPS HleuMSRTVZSUTSWVXYWW[ HileT[Z\^b[]\[_`^a^_c Hala \cbdfgcedch Hser dhgikmhjihlkn Hser inmoqsnponrqt Hileotsuw{tvutxywzwx| Hmseu|{}|~}| Hser } Hlys  Hlys  Hile Hala  _ala  _gly _ala  _asp Eala  Eile Eval Eleu Easp Eval Elys  Ethr _gly _ser  _gly _ala        _phe       Bmse  _lys  !#( "! $#%$&%'&) _thr!)(*,/)+*)-.,,0 Hleu*0/13702104356448 Hglu 1879;@8:98<;=<>?==A Hasp9A@BDHACBAEDFGEEI Hala BIHJLMIKJIN Hglu JNMOQVNPONRQSRTUSSW Hala OWVXZ[WYXW\ HleuX\[]_c\^]\`_ab``d Hala ]dceghdfedi Hhis eihjlrikjimlnompmqnqops Hala jsrtvwsutsx Hmsetxwy{xzyx|{}|~} Hvaly Harg  Hile Hgly Hasn Hasn Hval _gly _arg  _asn Ethr Emse Eala  Eile Eile Eser  Easp _mse _asn         _gln   _pro _leu!% "!#$""& _gly&%')&('* _arg '*)+-4*,+*.-/.0/1023115 Eala +546895765: Eile6:9;=A:<;:>?=@=>B Egly;BACEBDCF _asnCFEGIMFHGFJIKLJJN _ala GNMOQRNPONS _leuOSRTVZSUTSWVXYWW[ Hglu T[Z\^c[]\[_^`_ab``d Hleu\dcegkdfedhgijhhm Hgln elmknpknqzlmonlrmsptqurvxswytutu{ Hglu n{z|~{}|{~ Hala | Hile Hasp Hthr Hleu Glys  _gly _gln  _gly  _pro  Hlys   Hasp  Hleu  Hthr Hglu  Hleu Hval Hleu  Hthr           Hleu  Hgly Hser ! " Hgln "!#%*"$#"&%'&()''+ Hmse#+*,.2+-,+/.0/103 Hval,3246935437866: Hval4:9;=@:<;:>?==A Hleu;A@BDHACBAEDFGEEI _ala BIHJLMIKJIN _asnJNMOQUNPONRQSTRRV _lys OVUWY^VXWVZY[Z\[]\_ _ala W_^`bc_a`_d _glu `dcegldfedhgihjkiim  _thremlnpsmonmqrppt! Hleuntsuw{tvutxwyzxx|" Hglu u|{}|~}|# Hglu }$ Hala % Harg & Hala ' Hleu( Hleu) Hile* Hglu + Hala , Hile- Hasn. _ser / _gly0 Hala 1 Hala 2 Hleu3 Hglu 4 Hlys             5 Hphe               6 Hlys                    7 Hthr      !        "8 Hphe   " ! # % , " $ # " & % ' ( & ) & * ' + ( + ) * -9 Hile # - , . 0 4 - / . - 1 2 0 3 0 1 5: Hlys  . 5 4 6 8 = 5 7 6 5 9 8 : 9 ; : < ; >; Hasn 6 > = ? A E > @ ? > B A C D B B F< Ggln  ? F E G I N F H G F J I K J L M K K O= _gly G O N P R O Q P S> _gly P S R T V S U T W? _asp T W V X Z ^ W Y X W [ Z \ ] [ [ _@ Gglu  X _ ^ ` b g _ a ` _ c b d c e f d d hA Hthr ` h g i k n h j i h l m k k oB Hval i o n p r u o q p o s t r r vC Hile p v u w y } v x w v z { y | y z ~D Hasp w ~ }  ~  ~ E _his   F Gpro G Gglu  H Garg  I _leu J _pro K _gln  L _ala M _gln  N Etyr  O Egln  P Eile Q Eglu  R Etyr    S Blys               T _ala     U _lys                   V _lys       "          ! #W _ser  # " $ & ( # % $ # ' & )X Egly $ ) ( * , ) + * -Y Etyr  * - , . 0 8 - / . - 1 0 2 3 1 4 1 5 2 6 3 6 4 5 7 6 9Z Eval . 9 8 : < ? 9 ; : 9 = > < < @[ _thr : @ ? A C F @ B A @ D E C C H\ _glu A G H F I K F I L U G H J I G M H N K O L P M Q S N R T O P O P V] Bleu I V U W Y ] V X W V Z Y [ \ Z Z ^^ _val W ^ ] _ a d ^ ` _ ^ b c a a e_ Hser _ e d f h j e g f e i h k` Hasn f k j l n r k m l k o n p q o o sa Hasp l s r t v z s u t s w v x y w w {b Hile t { z | ~ { } | {  ~ ~  c Hgly | d Hval e Hala f Hser g Imse h Imse i Ileu j Igly k Iala l _gly m _arg  n _leu o _thr p _lys  q _glu  r _asp s _asp t _ile  u _asp               v _leu        w _ala          x _val               y Egly     !   "z Eile  " ! # % ) " $ # " & ' % ( % & *{ Eval # * ) + - 0 * , + * . / - - 1| Eleu + 1 0 2 4 8 1 3 2 1 5 4 6 7 5 5 9} _asn 2 9 8 : < @ 9 ; : 9 = < > ? = = A~ _lys  : A @ B D I A C B A E D F E G F H G J _lys  B J I K M R J L K J N M O N P O Q P S _ile K S R T V Z S U T S W X V Y V W [ _gly T [ Z \ ^ [ ] \ _ _asp \ _ ^ ` b f _ a ` _ c b d e c c g Elys  ` g f h j o g i h g k j l k m l n m p Eval h p o q s v p r q p t u s s x _glu q w x v y { v y | w x z y w } x ~ {  | } ~    _glu  y  _gly  _glu   Bser  _leu  Eleu  Ethr  Eile  Ehis   Eser  _asn  _arg   _gln   _asp  _val  Hasp     Hasp                    Hval                Hval                Hlys     " '  !  # " $ # % $ & % ( Hlys  ( ' ) + 0 ( * ) ( , + - , . - / . 1 Hleu ) 1 0 2 4 8 1 3 2 1 5 4 6 7 5 5 9 Hasp 2 9 8 : < @ 9 ; : 9 = < > ? = = A Gser : A @ B D F A C B A E D G Gser B G F H J L G I H G K J M Bile H M L N P T M O N M Q R P S P Q U _thr N U T V X [ U W V U Y Z X X \ Eile V \ [ ] _ c \ ^ ] \ ` a _ b _ ` d Eala ] d c e g h d f e d i _asp e i h j l p i k j i m l n o m m q _his  j q p r t z q s r q u t v w u x u y v y w x { _val r { z | ~ { } | {  ~ ~  _val |  _ser  _pro  _thr  _leu  Bile  _his   Elys   Eile  Eile  _thr  _glu    ?thm$   ?so4   ?so4   ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh!  ?hoh"  ?hoh#  ?hoh$  ?hoh%  ?hoh&  ?hoh'  ?hoh(  ?hoh)  ?hoh* ! ?hoh+ " ?hoh, # ?hoh- $ ?hoh. % ?hoh/ & ?hoh0 ' ?hoh1 ( ?hoh2 ) ?hoh3 * ?hoh4 + ?hoh5 , ?hoh6 - ?hoh7 . ?hoh8 / ?hoh9 0 ?hoh: 1 ?hoh; 2 ?hoh< 3 ?hoh= 4 ?hoh> 5 ?hoh? 6 ?hoh@ 7 ?hohA 8 ?hohB 9 ?hohC : ?hohD ; ?hohE < ?hohF = ?hohG > ?hohH ? ?hohI @ ?hohJ A ?hohK B ?hohL C ?hohM D ?hohN E ?hohO F ?hohP G ?hohQ H ?hohR I ?hohS J ?hohT K ?hohU L ?hohV M ?hohW N ?hohX O  ?hohY P  ?hohZ Q  ?hoh[ R  ?hoh\ S  ?hoh] T ?hoh^ U ?hoh_ V ?hoh` W ?hoha X ?hohb Y ?hohc Z ?hohd [ ?hohe \ ?hohf ] ?hohg ^ ?hohh _ ?hohi ` ?hohj a ?hohk b ?hohl c ?hohm d ?hohn e ?hoho f  ?hohp g! ?hohq h" ?hohr i# ?hohs j$ ?hoht k% ?hohu l& ?hohv m' ?hohw n( ?hohx o) ?hohy p* ?hohz q+ ?hoh{ r, ?hoh| s- ?hoh} t. ?hoh~ u/ ?hoh v0 ?hoh w1 ?hoh x2 ?hoh y3 ?hoh z4 ?hoh {5 ?hoh |6 ?hoh }7 ?hoh ~8 ?hoh 9 ?hoh : ?hoh ; ?hoh < ?hoh = ?hoh > ?hoh ? ?hoh @ ?hoh A ?hoh B ?hoh C ?hoh D ?hoh E ?hoh F ?hoh G ?hoh H ?hoh I ?hoh J ?hoh K ?hoh L ?hoh M ?hoh N ?hoh O ?hoh P ?hoh Q ?hoh R ?hoh S ?hoh T ?hoh U ?hoh V ?hoh W ?hoh X ?hoh Y ?hoh Z ?hoh [ ?hoh \ ?hoh ] ?hoh ^ ?hoh _ ?hoh ` ?hoh a ?hoh b ?hoh c ?hoh d ?hoh e ?hoh f ?hoh g ?hoh h ?hoh i ?hoh j ?hoh k ?hoh l ?hoh m ?hoh n ?hoh o ?hoh p ?hoh q ?hoh r ?hoh s ?hoh t ?hoh u ?hoh v ?hoh w ?hoh x ?hoh y ?hoh z ?hoh { ?hoh | ?hoh } ?hoh ~ ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh ?hoh ?hoh ?hoh ?hoh  ?hoh  ?hoh  ?hoh  ?hoh  ?hoh ?hoh ?hoh ?hoh ?hoh ?hoh ?hoh ?hoh ?hoh ?hoh  ?hoh! ?hoh" ?hoh# ?hoh$ ?hoh% ?hoh& ?hoh' ?hoh( ?hoh)  ?hoh*! ?hoh+" ?hoh,# ?hoh-$ ?hoh.% ?hoh/& ?hoh0' ?hoh1( ?hoh2) ?hoh3* ?hoh4+ ?hoh5, ?hoh6- ?hoh7. ?hoh8/ ?hoh90 ?hoh:1 ?hoh;2 ?hoh<3 ?hoh=4 ?hoh>5 ?hoh?6 ?hoh@7 ?hohA8 ?hohB9 ?hohC: ?hohD; ?hohE< ?hohF= ?hohG> ?hohH? ?hohI@ ?hohJA ?hohKB ?hohLC ?hohMD ?hohNE ?hohOF ?hohPG ?hohQH ?hohRI ?hohSJ ?hohTK ?hohUL ?hohVM ?hohWN ?hohXO  ?hohYP  ?hohZQ  ?hoh[R  ?hoh\S  ?hoh]T ?hoh^U ?hoh_V ?hoh`W ?hohaX ?hohbY ?hohcZ ?hohd[ ?hohe\ ?hohf] ?hohg^ ?hohh_ ?hohi` ?hohja ?hohkb ?hohlc ?hohmd ?hohne ?hohof  ?hohpg! ?hohqh" ?hohri# ?hohsj$ ?hohtk% ?hohul& ?hohvm' ?hohwn( ?hohxo) ?hohyp* ?hohzq+ ?hoh{r, ?hoh|s- ?hoh}t. ?hoh~u/ ?hohv0 ?hohw1 ?hohx2 ?hohy3 ?hohz4 ?hoh{5 ?hoh|6 ?hoh}7 ?hoh~8 ?hoh9 ?hoh: ?hoh; ?hoh< ?hoh= ?hoh> ?hoh? ?hoh@ ?hohA ?hohB ?hohC ?hohD ?hohE ?hohF ?hohG ?hohH ?hohI ?hohJ ?hoh@Cvȴ9!U$/.Sn d@D + #1&x,-ca d@D"m)c 2@DGzH)q&xo d@D;dZ#t- =pcb 2@E2m!Z1-WO;dog @DzH#ܬ1&' =pn d@D1$/# O;dZ% ca d @D ě!Xtj$vc 2 @D+ I^5?#Stj~o d @D@D-O;dZ,(\od2 ?@D"`?öE"En d@@D\(?r ěQca dA@EVfffff?\(\ ěc 2B@EP@ =pno dC@D`"`BÕ$cb dD@C9XbNxFB\(cg1 dE@DR I^5?nO;dZcg2 dF@Cb\(ÿtjw+cd1 G @E+?"`B+ Jn dH @F|I^5??\(lca dI @FVu@-VVuc 2J @FěT@ $/ǮzHo dK @G V?tj~cb dL @FQtjcg1 dM @G+ ?tj,1&ycg2 dN @GF-"`Btjcd1 O @FdZ@`A7 mVn dP @G&x@ ^5?|!Ƨca dQ @Fx@E!{dZc 2R @Fщ7Kƨ@Vu!7KƧo dS @G5Q@ \($cb dT @GF@"`$-Vcg dU @Ghr?Vu'cd !2V @G+ @vȴ9)j~#oe1 2W @H|1&?"`'O;oe2 X @EM@n!vȴ9Xn dY @EpbM@l!C$ca dZ @E-V@A7K1&xc 2[ @Ex@Z1Z1o d\ @DA7K@`A7K!O;dZcb d] @D*1'@F!mcg d^ @C?|h@7Kƨ"O;dZcd d_ @B ě@Vu"KƧce ` @BGKƧ@O;#nz a @ES@tr Ĝn db @EnO@Y+ + Jca dc @FRm@ O;dZ"`c 2d @Fa$/@x-Vo de @EE@333333$/cb df @E`A@2-Vtjcg dg @E>Q@DSnOcd dh @Dx1&x@\(\-Vce i @D/w@$/Z1'nz j @Ft@bMSn dk @G9XbN@w+Eca dl @GzG@"`7KƧc 2m @Gȴ9X@!=p ?|ho dn @Gj~@vȴ9XA7Kƨcb do @H;dZ@glCnOcg dp @I ^5?}@Vu'-cd q @HƧ-@|hr!!Gzne dr @Ho@?|h#Qcz s @I_|hs@x#;dZnh1 t @HI^5?@+ I% I^nh2 u@G'+ I@ >"`A7Ln dv@G;dZ@"XbM/wca dw@F =p@$ɺ^5?}j~"c 2x@FS@&Ձ$/;dZo dy@F9XbN@"1&"Dtjcb dz@Gl1&@ n#~"cg !2{@Ho@ 5?|#tjod1 2|@G;dZ@vȴ& od2 }@F`A7K@$1l^5?|n d~@Ep =@& =pnca d@E?vȴ9@%p =tj~c 2@D1&x@'lCW =po @D-V@$\(\(n d@DKC%@$ C%tj~ca d@CO;dZ@"\(hr c 2@Dvȴ@ tj\)o d@D*vȴ@"lC A7Kcb d@D?|h@$LI^5?">vȴ9Xcg @D`A7@'nP"nnd1 d@E ^5?|@#Dtj#?|hcd2 d@Dvȴ9X@'bM$ ěce1 !@EH9Xb@%["`B%xQne2 !@C6fffff@#5\(=p n d@B&x@!"`Aca d@B ě@1&Vtc 2@Bd9XbN@lC$/o d@BI^5?@#u?|hDScb 2@Avȴ9@#ilD333333og1 d@BI@&\1&`Acg2 @BC%@-VSn d@BNVu@`A7tjca d@A+ @ I^C$c 2@A<@dZ1+o d@B1&y@QR.zGcb d@C`ěT@XbM+ I^cg d@C@dZ1 (\)cd1 d@CěT@ -VQcd2 @A;S@ I^5`A7n d@@ =p@9XbN\(ca d@@[dZ@ 1&~"c 2@@^5?|@-V+ o d@@=-V@ zG{Ecb 2@@tj~@Eqlog1 d@@c =p@ \1&cg2 @?xbM@ -Vp =n d@?o@lC dZ1ca d@?Ffffff?lClCc 2@?vȴěS"`o d@=tj@-V =pcb 2@=Tj~@ (\)nOog1 d@=zH?vȴ-Vcg2 @?M?$/ ěn d@?;SϿbMH9Xbca d@@Xtj$//vc 2@@}-V+bMo d@>ȴ9Xb?|hstj~cb d@=GzH9XbM$/cg d@vȴ9Xc 2@BlC&xj~#o d@AQ?hr Scb d@AƧ?\( ěcg d@BE@lC O;dZcd !2@B?-V@#5\(oe1 2@B'O;d@ -vȴ9Xoe2 @Axr ĜQ I^5?}n d@ASϿr ě"`Aca d@AU\(/vɿěSc 2@AGz`A7KǿGzHo d@A^+?tj~ۿ9XbMcb d@Atj~?tj =pcg1 d@Ax9Xb ěT?-Vcg2 d@Av+ J@333333 =p cd1 @@ =p+ IVtn d@@ix I^5?Sca d@@O;dZE-Vc 2@@ߝ-V:^5?|p =qo d@?b\( hr ĜKƧcb d@>mO;dZ~"QRcg !2@>tj"`AVuod1 @=7+|hrhr!nd2 @A- ěO;dZn d@AilDKƧca d@B-V\(+ Ic 2@BAGzvȴ9XbMo d@ACtj~dZ1cb d@BXbMI^5?1&xcg ad@A"`B$/zG{cd1 Vd@BI^5??|hscd2 ed@B~O;O;dZlCce1 ed@CAlZ1'ȴ9Xbce2 Vd@C"`A:^5?| $/cz V@Bg =pt $/n d@C$/O;dtj~ca d@BbM+ Ixc 2@C9x&x(\)o d@CY+ Vt$/cb d@CXbM tj?|hscg ad@Db ě =p j~"cd1 Vd@Cļj~1&xտ;dZcd2 ed@DFhr ĜXbMce1 ed@D8bM`A7?Ƨ-ce2 Vd@Dhr  ě?/vcz V@Bo\(hr Ĝ"`n d@BVxbM?"`Bca d@BG{š?zG{c 2@B`bM E?"`o d@A1&y I^5??\(\cb d@B5S@XbMcg1 d@A(\hr Ĝ@-Vcg2 d@BQ'-@"`Bcd1 @Ap =qlVun d@AY7KƧ!lD\(\ca d@A$/#hrZ1'c 2@AQ&+ KƧo @BGO;d"-~"n d@BθQ$(\)nca d@C_v$tj~9XbMc 2@C+ I'S-o @ClC" I^+ n d@DZ1#CnP-Vca d@C|hs%nO;?Qc 2@D;C%'^5?|? ěo d@D;Q $/?bMcb d@DěS O;?\(\cg ad@Eal!?O;dZcd1 Vd@DO;dI^5?}@"`Bcd2 ed@Evȴ9X!V@hr ce1 ed@E$tjVu@zGce2 Vd@Evȴ9 ۥS@ Vtcz V2@F:^5?|!\(@Vuoh @CFt%7+?GzHn d@Co' ^5?}@tjca d@CZ1)V?hr!c 2@C333333+Ձ$/@j~#o d@Bp`A7%33333@ xcb d@A33333'Q@&xcg1 d@B|&Q@+ cg2  @B?|h*/-V??|hsn d @B1&y,VuzG{ca d @Ct9XbN.bMlCc 2 @Cvfffff0<1&nPo d @Bb ě,/w1&ycb d @AE,r ě1&xcg d @A9x,dZtjcd d @AP =q*Ձ$/ vȴ9ce  @@-*\)-Vnz  !@C|hs,+lCn d !@D =p-O;dZ;dZca d!@D"`B- ^5?}~"c 2!@EIXbM.lCo "@DYx+/w-Vn d"@DqR+1&+ I^ca d"@D33333(lCSc 2"@E n(z^5?|šo d"@C=p *m+ Icb d"@CT9XbN,vȴ9XQcg !2"@Cn/KC%P`A7od1 2"@B=p ,xF-Vod2 #@D^5?|&?|h lCn d#@Ei$;dZ`A7Kca d#@Ej~#$և+ J`A7Kc 2#@Evȴ9X$Z11&xo d#@E "`B!KƧ hr cb d#@D I^5!+ I+ Jcg1 d#@EQVt GzHcg2 d#@DnO9XbN1&cd1  $@Fn$lC I^5?n d!$@G(tj%oca d"$@GR`A#u?|hC$c 2#$@G2-V!`A7&xo d$$@G&x&1' dZ1cb d%$@G5?|%"M0 ěcg d&$@Fhr $+ocd '%@GG{$PbMʟvȴ9n d(%@GnP"$/?lCca d)%@H< 4j~?`A7Lc 2*%@H*nZ1?So d+%@HA&x$ I^5?~"cb d,%@G =p%y"`@\(cg !2-%@G;C%%"`B@tj~od1 2.%@H$S';dZ@C$od2 /&@HƧ O;dZ\(n d0&@I ěvȴ9X+ca d1&@H+ I+ I^5?c 22&@I "`nPhr Ĝo d3&@Iȴ9XGznPcb d4&@IO;d!n Ƨ-cg ad5&@IU`A7L -VQcd1 Vd6&@I(\$DS Ecd2 ed7&@I(9Xb!{lCo-Vce1 ed8&@IbM%O;(\)ce2 Vd9&@I.O;$B\(O;dZcz V2:&@I I^5%\(+ I^oh ;'@H2m&xQn d<'@GǍO;d I^5? 7KƧca d='@G` =qhr!c 2>'@GS =p GzH1&o d?'@GSS["`B)lDcb d@'@Gvȴ9X~"H9Xbcg dA'@G;Shr ncd !2B'@Ftjmoe1 C'@Go\(-VVne2 D(@Ghr!hr5?|hn dE(@FšStj~ca dF(@G9XbM1&y?lCc 2G(@FQěS?1&o dH(@Fyql?Gzcb I)@G܋CbM?+ In dJ)@HO;dZ 9XbN?KƧca dK)@Hvffffftj~?/wc 2L)@H-VA7Kƨ?|hro dM)@HlD,1&y@lCcb 2N)@II|hr?`A7Kog O*@Hj~#Gz^5?|n dP*@H33333tjVtca dQ*@H;dZ`A7j~"c 2R*@H;C%?VunPo dS*@H1'zGXbMcb 2T*@IGzO;dZ /wog U+@GnO߿p =qSn dV+@FF?KƧI^5?}ca dW+@F33333?S?+ Ic 2X+@Fhr!@vȴ9X?lo dY+@F@ =qƧ- I^5?cb dZ+@EbM?9XbMӿlCcg d[+@EěT?zGcd1 d\+@DtjQRvȴcd2 ],@G-?A7Kƨ?ěSn d^,@Gj~?tj~@ca d_,@GzG?I^5?}@Qc 2`,@GZn@1&y@ \(o da,@G#tj~QR@ ?|hscb b-@H ?E@~"n dc-@HGz@\(@+ ca dd-@HgzH@|hr?lCc 2e-@H~"@_;dZ?Eo df-@IT/@lC?+cb dg-@InO@ p =q?hr cg h-@Ip =@=p =@ `A7KSe di-@JbM@/v@Ƨ-ce j.@H =p@ r ě?1&n dk.@G`A7@!olca dl.@GGKƧ@E@ o?hr!ca d7@?+@Rm?Ec 27@?WO;d@;dZ?$/o d7@>&x@!zH?&xcb d7@=}/w@#"`B?-Vcg !27@<+@$# =p?/wod1 27@=q&x@%O\(땁$/od2 8@@bM@tj~?vȴ9Xn d8@AzH@=p ?`A7Lca d8@AKƧ@1&y@C$c 28@A|hs@XbM@tjo d8@Ar Ĝ@r ě?j~"cb d8@Aȓtj@vȴ9Xcg d8@BtZ1@+ J$/cd !28@Bv@!\(oe1 28@Bش9Xb@-V =poe2 9@A0bM@|hs@ Sn d9@A9@nP@8Qca d9@@@["`B@lCc 29@@$/@ -V@'-o d9@A_vȴ9@l@Rmcb d9@B$/@$/@Qcg d9@BKƧ@!dZ1@+ cd 9@BbM@"o@F-ne d9@B@$7KƧ@ =pcz 9@Btj@%["`B@ y"`nh1 9@C&x@&nO@1'nh2 :@@E@ix@dZn d:@>&x@Z1'@^5?|ca d:@>˅Q@ bM@TEc 2:@>C%@lC@ I^5o d:@=;dZ@^5?|@ɺ^5?}cb d:@@> I^5؃nP@vȴ9n d>@=lDnO@1&xcaad>@=7Kƨ =p@Ecabd>@=lC$/@lCc !2>@=tzG I^5?}@nPo d>@@@;=p ?m@XbMcgad>@;$?bM@j~#cgb>@;"`B?-V@qlSea>@9j~#?;dZ@!oSebd>@:@Vu@Õ$cead>@9\(ÿ+@DSceb?@>;dZ@nO;n d?@?/ 7KƧ@ hr Ĝca d?@@ C%mhr!@ɺ^5?}c 2?@?9Xb@n@ffffffo d?@@P KƧ@\(cb @@@f+ J8Q@KƧn d@@@hrC%@ca d@@@\(ȴ9Xb@33333c 2@@@!hr y"`@"o d@@A9lD1&@?|hscb d@@Aj~#333333@Vucg @@B+ zG{@>vȴ9XSe d@@B9^5?}@"`Bce A@?ESnP@&xn d A@> nKƧ@ Qca d A@=vEe`A7L@bMc 2 A@==p =33333@ `A7o d A@<(\r ě@!nO;cb d A@;nO@"Qcg1 dA@=SQ@#`A7Kcg2 B@=LI^5?ěS@ěTn dB@zG fffff@n dC@?`A7#-hr!@vȴ9ca dC@?Z1'%y"`@-Vc 2C@?'C@lo dC@@^5?}"w+@ I^5cb 2C@@`A7L!-V@og D@>zG%\(@1&xn dD@>XbM'S@!nOca dD@H@1\)"k I^@,Õ$cg !2?H@1ix @-:^5?|od1 2@H@0˅Q$$/@,I^5?}od2 AI@3pbM;dZ@1%`A7Ln dBI@2;dZl@2}p =ca dCI@1\(&x@2;dZc 2DI@1-VI^5?@3 =po dEI@3ؓtjJn@3GlCcb dFI@5Mhr! ěT@3XFcg dGI@6+-V@4%Qcd1 dHI@5[dZ h\)@39Xbcd2 IJ@0&x8Q@1^vȴ9Xn dJJ@/nbM@149XbNca dKJ@,xx@2.+c 2LJ@+7Kƨ~"@2rmo dMJ@-xzG@/O;dZcb 2NJ@-+|hr@.O;og OK@-333333$/@21&yn dPK@+KC% ěT@3$/ca dQK@+šhr@5-Vc 2RK@**~" hr!@5bMo dSK@+Dtj#l@31&cb dTK@*=E% O;dZ@2H\)cg !2UK@(\(#$/@1tjod1 2VK@+/v',1&y@1/wod2 WL@-O;hr @5L1&yn dXL@.aoQR@6-Vca dYL@-vȴ9+@6|hsc 2ZL@-j~#?|h@5So d[L@0lD7Kƨ@6`Acb d\L@1R ěJn@6^5?}cg1 d]L@0KƧV@849XbNcg2 d^L@2zGDS@7.O;cd1 _M@+PbMv@7n+n d`M@)O;dZ nO;@7d/ca daM@+SlC@7-Vc 2bM@-$Z1\(\@8Qo dcM@'j~" ȴ9Xb@8`cb ddM@%tjQ@8MVcg deM@"|hs I^5?@97KƧcd dfM@" Ϳm@9lCce gM@ \(ÿj~"@;NVunz hN@*FI^5?}@7 C%n diN@,["`B7KƧ@7:1'ca djN@.bM?"`A@6Z^5?|c 2kN@/k I^Ƨ-@5tEo lO@0&$/? =p@67KƧn dmO@1P`A7?\(@5Qca dnO@2-?9XbM@67Kƨc 2oO@2~"?$/@7I^5?o dpO@1e@-V@5?|hcb dqO@2M@ +@4vȴ9cg1 drO@033333@ $/@5>5?|cg2 sP@3=/w? ěT@5$/n dtP@4`ěTxF@6Vca duP@5Ƨ?׍O;dZ@6 ě@l@: xcb dS@?&x@ + I@:}/wcg dS@@8r Ĝ@lC@:lCcd dS@@9XbM@+ @< 1&yce S@@\(? ěT@< nnz T@@O;d@9XbM@7Ovn dT@@-V?j~"@6`Aca dT@A9+ @Gz@7eQc 2T@A*G{@Q@78Fo dT@@fffff?ěS@5[Scb dT@Aw+?m@4Ccg T@A1'E@4Qnd1 dT@Bt?dZ1@4nPcd2 dT@BMhr!9XbM@4Vuce1 !T@BO;d? =p @4c =pne2 !U@A@C%@8 =p n dU@BMhr!@\(@8rnOca dU@BZ1@1&x@71&c 2U@Co?XbM@7xtjo dU@Bxtj@tj@9xcb 2U@CQ@ ȴ9Xb@:@og V@CGKƧ@ ^5?|@7-Vn dV@C9Xb@ A7Kƨ@6p ěca dV@Dn"@nO@7`c 2V@Dvȴ9?+ @6`A7Lo dV@D6E@dZ@5Scb 2V@DdzG@ ě@6Qog1 dV@Cx@'-@41&ycg2 W@DTE@+ I^@8bMn dW@DXbM?x@9O;ca dW@E"m@@:Ec 2W@Ef$/@ -V@:3o X@E@bM@KƧ@;-n dX@E+ I@x@<bMca dX@E-V? =p @>Rc 2X@ED/?$/@>1'o Y@FXF@bM@>9Xbn dY@F|j~#?@?7KƧca dY@FS?=p =@@Gzc 2Y@ES@Q@@fffffo dY@GO;dZcb d[@CME@\(@=zHcg !2[@C @/v@>;dZod1 2[@C:G{@333333@<"`Bod2 \@Bݲ-V?;dZ@A ^5?}n d\@Bfȴ9X?lD@AVtca d\@A/w?+@A@bMc 2\@A=p =?ffffff@AzGo d\@B1'KƧ@BScb 2\@B#33333?O;dZ@B+ Iog1 d\@CIlD?O;dZ@BA&xcg2 ]@AO;dZ?&x@@ =qn d]@@XbM?GzH@@-ca d]@@b`A? ě@@fEc 2]@?^5?}?`A7L@@mo d]@@E@ C$@@tjcb 2]@A?|h@n@>oog1 d]@AX\)@H9Xb@@Y7KƧcg2 ^@@n?+ I@?Rn d^@@$/GzH@?Qca d^@?f$/r ě@@]-Vc 2^@>2nO߿-V@@^zGo d^@@G+ Ij~#@>cb 2^@@m-V+ J@=GlCog1 d^@?QVt@>NzGcg2 _@@^5?}E@@n d_@?E@Avȴ9Xca d_@>xvȴ9@AzGc 2_@=vȴl@B+ Jo d_@@jG{C$@Ahr cb d_@@O;Vt@AnOcg d_@AvlC@B5Qcd1 d_@@(\bM@AMcd2 `@>zG =p @An d`@=lC?д9XbN@B1hr ca d`@<ȴ9X?vȴ9X@A-c 2`@;S?j~#@A\)o d`@>C%?p =q@Bi"`cb d`@=@\(@Bȴ9Xcg1 d`@?x?$/@B5?|cg2 a@=bM?홙@Axn da@< ~"?lD@@-Vca da@:tj~?5?|h@@vfffffc 2a@9͑hr!?;dZ@@e$/o da@<n?/v@? =qcb da@=8tj@ lC@@ ěcg da@>)7KƧ@ O;dZ@>r Ĝcd1 da@<E@$/@@ Qcd2 b@;G+ Itj@@k"`Bn db@:C =p =p @@DzGca db@9E ěT@@/c 2b@7Ϳ;dZ@@bMo db@: I^ ^5?|@@+ I^cb c@9YE@AlI^5?n dc@8E-V@A$/ca dc@7vɿ^5?|@Ac 2c@6w =p׿n@B+ Jo dc@8㕁$/w@B-Vcb dc@:`ěTěS@Bw =pcg dc@:$/Gz@A1&cd d@81&x?j~"@AEn dd@8\)?+ J@Bmca dd@6E@lC@A"c 2d@5=p @-V@AQo dd@96+ J@ ěT@B I^5?cb dd@8tj@w+@B1&xcg dd@8" I^5@)lD@BlDcd1 dd@:49XbN@-V@B0ncd2 e@7S?/v@@O;dZn de@6xF@@@^Vuca de@56ȴ9X?+@@V-c 2 e@4(\@=p =@@Fxo d e@7Qhr @vȴ9X@?nzGcb d e@6xtj@KƧ@>0bMcg1 d e@8B\(@ r ě@?i^5?}cg2  f@5_;dZ?+@@klCn df@4>"S@@|Cca df@3E`A7LlC@A hr!c 2f@2 x"`@AMo df@41&x1&@@vȴcb g@3zG?Vt@A-n dg@3 x?nO;@B*1'ca dg@2)x?zG{@BZ1c 2g@1,?zG@B_;dZo dg@3^5?}?x@BbMcb h@2y@$/@A|hsn dh@1hr!@ +@AKlCca dh@0KƧ@ =p@@Qc 2h@0CS@["`B@@Qlo dh@2LC@O;d@A;Ƨcb dh@2I^5?@H9Xb@A/cg1 dh@3a$/@@@j~cg2 i@0t?/w@@5?|n di@/`A7K?5?|h@@ Qca d i@0Fx?;dZ@>c 2!i@/$Z1?1&x@=xo d"i@,@p =q@@ bMcb d#i@*N+?\(@@`A7Lcg !2$i@* I^5$/@@\(od1 2%i@( Ƨ?+@?-od2 &j@1+ J?333333@>Sn d'j@2@?A7Kƨ@=:G{ca d(j@2/?ȴ9Xb@m@8RE@8o d?m@5Q"`@80`A7cb @n@9 n(\@:j~#n dAn@:Vu\(@:Gzca dBn@;9"`\(@9pbMc 2Cn@;tj!;lC@9\(o dDn@;,CA7K@;]Ecb dEn@< =qRm@;NVucg dFn@<1&xKƧ@:Scd dGn@>O;dZS@:.+ce Hn@>_|hsp =q@9O;nz Io@< 1&x@8mhr!n dJo@cS\)@8ffffffc 2Lo@>ݲ-Vffffff@8 lDo dMo@o"A7K@5Լj~cg Oo@=Vu# A7K@3"`BSe dPo@< =p $tj@3ěSce Qp@? x!tj@92-Vn dRp@@0 =p@9Sca dSp@@C#O;d@9_;dZc 2Tp@@O;d$š@8-o dUp@@+S 5?|@;Dtjcb 2Vp@?lDG{@;O;dZog Wq@A=-V#*~"@: hr!n dXq@AbM%I^5?}@9&xca dYq@B3tj~%\)@:Ec 2Zq@B bM$xF@< xo [r@BE'P`A7@:Rn d\r@C ěnh2 fs@DI"`'l@:\1&n dgs@Də&hr@9y"`ca dhs@Ettj& =p@:$/c 2is@E =q'\(@;.zGo jt@E/$wKƧ@9WO;dn dkt@FO;d#"@9(\ca dlt@F|hs!3E@:+Ƨc 2mt@FKƧGzH@: I^5o dnt@F$$A7Kƨ@8Y+ cb dot@F\(&;dZ@7\)cg dpt@G[ I^&ěS@6G+ Icd1 dqt@Fvȴ9)k I^@8ixcd2 ru@G- m@:j~#n dsu@G#tj~33333@;ilDca dtu@Gqo@7Kƨca dxv@Gi7KƧ"`A@?Qc 2yv@GO;dZ@@Q&xo dzv@G =pY+ @>1&cb d{v@HAo 1&x@>\(cg |v@HVu S@=?|hnd1 d}v@H&-nO;@= =pcd2 d~v@I|hs/v@eSo dw@ElnO;@@Gzcb 2w@Et/@@NQog1 dw@F\1& C%@A1'cg2 x@EU$/ t@@)lDn dx@Dҏ\("k I^@?O;ca dx@DN+ x@?`Ac 2x@DK I^ffffff@?49XbNo y@Cj~!C@>1Rn dy@CWKƧ vȴ@=-Vca dy@BlC t@>nOc 2y@BěT!`A@?$o z@B>zGbM@>:^5?|n dz@AvQ@?'+ Ica dz@Ao-V!@?+c 2z@ACnP!ۥS@@nQo dz@AO;dZdZ@>z1'cb 2z@AVfffffj~"@>+ I^og1 dz@@~"S@?XbMcg2 {@Ag+# =p@>&xn d{@A*1'&C$@??vȴ9ca d{@AZ1'Z1@@|hsc 2{@Ajn)"`A@@$/o d{@A =p(tj@> 7KƧcb d{@@e'@=B I^5cg1 d{@@V*hr@>vȴ9Xcg2 d{@@CnP(/@;;dZcd1 |@BIx'B\(@@ XbMn d|@BǍO;d(TzG@@Mca d|@Br Ĝ'/-V@A2Mc 2|@BbM(hr@AGzo d|@C}-V'Gz@@O-Vcb d|@CS)-hr!@?f-cg !2|@Ctj~+ ě@?["`Bod1 2|@CbM'\(@>{"`Bod2 }@B=p $@A89Xbn d}@BqGz#!o@Aش9Xbca d}@A+$ @B7+ Ic 2}@AV$z^5?|@BSo d}@Bp`A7 !Gz@A~"cb d}@CxF@AxQcg d}@C+ƧƧ-@AQ$/cd d}@C1&x0 ě@@/wce }@DE1'@@p =nz ~@AFE$dZ1@Atn d~@@x%PbM@Bj~#ca d~@@1'(8Q@BYc 2~@@_-V) n@Bϝ-Vo d~@@vȴ%#S@A-cb d~@?-"_;dZ@AkƧcg d~@>/w"nP@@C%cd1 d~@? 1&y!1'@B ^5?|cd2 @A-hr!)n@B Sn d@AFt,S@BE$/ca d@A$/,S@BA7Kc 2@A+ I.bM@C3 =po d@A.3E@Acb d@A2 ě. =q@A-cg d@A=p 0MV@@Z1cd !2@A6E18bM@@eQoe1 2@Bhr!0Z1@@uQoe2 @A+ I*QR@C6En d@B`A7*RnO@C~"ca d@A-V+(r Ĝ@DcEc 2@A$/+ ě@D ěo d@BWzH'`A7L@D cb @@Gz*Z1@D-hr!n d@@Ov+Q@D/ca d@@-.&x@Dqhr c 2@@`A/s33333@C"o d@?^Q* ^5?}@Dj^5?|cb d@?/w'Q@Dr Ĝcg1 d@>bM*"`@Dϝ-Vcg2 d@>fffff%O;dZ@DX9Xbcd1 @@6-0,C@DSn d@@ ě1vȴ9X@Dr Ĝca d@>Ձ$/1㕁$@D5?|c 2@=̋C1Y+ @Dno d@@`A2>5?|@EƧcb d@@2Y"`@E =pcg !2@A0`A72-hr!@EnOod1 2@@ ě2$@F$od2 @> I^52nP@D5?|n d@=l3$/@CMca d@=Zvȴ2_|hs@CMc 2@Z10Gz@A̬1&c 2@?/;dZ1L@A5?|o d@>`A7-ɺ^5?}@Btcb d@=lD,+ I@A =pcg ad@xF+ěS@AgzHcd2 ed@<)GzH@Ao-Vce1 ed@> =p*9XbM@@5?|ce2 Vd@

Vuo d@=EQ2m@@/wcb d@; ě3#$@@Scg @:Q35$/@@O;nd1 d@;7Kƨ3Hr Ĝ@A5cd2 d@9A7K3l1&y@@P =qce1 !@9G{3{S@@ne2 !@=6t01&y@>+ Jn d@mcg1 d@>+/+ I@<9XbNcg2 @;Ձ$/2mhr!@=B`An d@;f$/3Q@=p =4@;G{cd !2@= =p45?|@:vȴ9Xoe1 2@?\(\3E@;-Voe2 @9U$/2j~"@;vȴn d@7\(2Qhr @;Vca d@7dZ2G-@: ~"c 2@8j=p 1Ƨ-@9CnPo d@7BM15?|@Qcd d<@*p =0m@>1&xce =@'/0&x@? ěnz >@0ΗO;(tj@=n d?@1z^5?|&?|h@> ěTca d@@1~5?|#\(@=33333c 2A@11l"=p =@>䛥So dB@2=p 'n@>G+ Icb dC@3$/*;dZ@>lCcg dD@4x+q&x@? O;dZcd1 dE@2AGz*vȴ9X@@vȴ9cd2 F@1ȴ9X"tj@eSn dV@*lD!mhr!@?Mca dW@,hr ĜS@@e`A7Lc 2X@+&fffffvȴ9@@o dY@*R$Rm@@+ cb dZ@({dZ%@?bMcg d[@(;dZ(;dZ@?\)cd !2\@*W =p)C@@X1&xoe1 2]@&Z1*I7KƧ@?WKƧoe2 ^@/$/E@@M-Vn d_@0_vȴ9@n@@-caad`@0V+ Jvȴ9@@"`cabda@1"\(_;dZ@@;dZc !2b@1+vȴ9@@5?|o dc@1e`A7L Q@A cbadd@1NVu 7Kƨ@A!hr cbbde@0o"zG@AHFcga!df@1fffff$/@Aѩlcgb!2g@0hr$j~#@@Z1od1a2h@0Qp =@B6-od1bi@0-V"hr @AFnd2aj@3r ĜbM@AXbMnd2bk@1 C@?nOn dl@1o5?|h@>1&ca dm@3DS/w@>bMc 2n@4 I^5j~"@>p =o do@1LI^5? bM@?;dZcb dp@/-V^5?|@? cg dq@/m333333@=Ƨcd dr@,l$/@= =pce s@*zG l@<Qnz t@3Õ$@?VEn du@5333333Vu@?2nOca dv@5xtjnO@?\(c 2w@4+ ^5?|@?Mo dx@6GzJn@@2Mcb dy@5Ex@@dZcg1 dz@7Z133333@@Z1cg2 {@6xFdZ@>1hr n d|@7zH"nO@>Qca d}@8`ěT"Vt@=mO;dZc 2~@8nP Y@<|hso d@6F$glC@=NzGcb @9=-V$[S@=O;n d@:;dZ$A$/@< I^5ca d@:hr&x@<5$/c 2@:C)+ I@<Ƨo d@;F#w+@=+cb d@= Ƨ#-V@=tj~cg1 d@;&x zG{@>U?|hcg2 @;F-&ěS@:&xn d@;=p )Q@:B I^5ca d@=,I^5?(;dZ@9ǮzHc 2@= I^5&E@9vȴo d@: ě*1&x@9-Vcb d@9l+r-V@9-Vcg1 d@:/'v@8"cg2 @=׍O;d*33333@9dtjn d@?&fffff*ql@8Gzca d@?hr )׍O;d@7D/c 2@>n)hr @6Qo @@Ƨ)S@6|hsn d@@"M(zG@56Eca d@?$*KƧ@4`A7Kc 2@?n-MO;dZ@4$/o d@@ܬ1&(/w@4A7Kcb d@AC&hr @5TEcg d@A|hs#;dZ@4xcd !2@Atj#q&x@3hr!oe1 @@ڟvȴ" O;dZ@5xne2 @> =p*1'@3\hrn d@>=E,;dZ@2aGzca d@?e`A7L-KC%@1nOc 2@@DZ1,nzG@1$/o d@=.zG*zG@1q&xcb 2@=m("@0nPog @?+ J/KƧ@0+ In d@@ =q0mO;dZ@0XbMca d@@` =q/"`B@- ěc 2@@l0'zH@-$/o @@ =p-hr@,_vȴ9n d@@?-V,p =@)tjca d@@O;)Ƨ-@)Jnc 2@?{lC)@'Lo d@?"`.tj~@'hr cb d@@CnP.hr @$1'cg !2@@A7K-G{@$-Vod1 @?G{.S@"hrnd2 @@1o(bM@+9XbMn d@@hr %9XbM@*`A7Lca d@@zG#KƧ@)tc 2@A7 =p$S@)5?|o d@@tj#"`@--cb d@?q&x!^Q@./-Vcg d@=+ J!R@.dZcd1 d@@bM+@0>"cd2 @@gO;d"xF@'zHn d@@$/ E@%LI^5?ca d@A$/"XbM@$tjc 2@B Ƨ!2 ě@%Qo d@@CKƧ@&vEcb 2@AK I^ =q@)+ Iog1 d@@W-š@&1&xcg2 @Ay7KƧ$ I^5@#\(\n d@B1&x& O;dZ@"+ Jca d@BQ$W =p@ šc 2@C'lC$fffff@ xo d@A&x(@!vȴ9cb d@A(\)(R@ PbMcg d@@l&2 ě@"glCcd @B?;dZ";dZ@5?|hn d@Btj (\@^5?|ca d@Cvhr@$/c 2@CzGl@vȴ9Xo d@B6-XbM@\(cb @B I^C$@!I7KƧn d@C*=p p =@#zGca d@Chr |hs@$Fc 2@D9"`@%@no d@BS\)@$|hscb d@Cfffff\(@&Qcg !2@Ci lC@&nPod1 2@CzG+ I^@)_vȴ9od2 @ClC TzG@%O;dn d@Dv!S@&hrca d@DXbM" =p@%"`Bc 2@E;dZ!|hs@%?|ho d@CE$E@'^5?|cb d@CDZ1$m@*1&xcg d@C `A7't@*r Ĝcd d@BgKƧ(=p =@+lDce @BE?|h+tj~@,O;dZnz @D9Xb"x@"n d@EěT#,1&y@ oca d@Emhr! xF@ C%c 2@F hr @@ J=p o d@DZ1$9Xb@N+cb d@E@%7Kƨ@ȴ9Xcg d@DbM&`A7L@ I^5cd d@EDZ1(I7KƧ@ I^5ce @Ex*|j~#@nz @E vȴ+@Z1n d@EZ=p -@ I^5ca d@E~"`A7L@!\(c 2@FDSzG@ So d@D+ fffff@bMcb d@EƧ I^5?}@kQcg d@Evȴ9=p =@~"cd1 d@DKƧ@Jncd2 @EyxQ@#}p =n d@E\(@%"ca d@Fvȴ9ěT@&KƧc 2@GMQ@&Ƨ-o d@EhbM1&x@(CnPcb d@Ex@*\)cg ad@E;dZQ@+`A7cd1 Vd@F ěO;dZ@,vȴ9Xcd2 ed@FKC%E@-2-Vce1 ed@Fttjx@.vȴce2 Vd@F5?| S@."`cz V2@F/wbM@0I^5?oh @Fvȴ9ȴ9X@&tjn d@G =p%S@&~vȴ9Xca d@GxI^5?@$\1&c 2@H2nOE@$Eo d@FXbM"tj~@&[Scb @G_;dZ+ @!Mn d@G I^5zG@dZ1ca d@HfffffsE@ %`A7Lc 2@H`A7 I^5@o d@Gw-tj~@hr!cb d@G㕁$S@ ěcg d@Hvx]/w@8Qcd1 d@GtSw+@Ƨ-cd2 @GtR@ En d@GShr @!ca d@Ha&xM@#5?|c 2@Hܬ1&^5?|@#P`A7o d@G:1'QR@"zGcb d@Fj~#333333@ TzGcg d @F ƧI^5?}@!O;dZcd  @F9Xb&x@#$Z1ne d @Em?vȴ9@%9XbMcz  @E5`A7L@%j~#nh1  @Eȴ9Xb?$/@&šnh2 @HS =p ^5?|@%;dZn d@HθQ ěS@'ca d@IM?|h@&p =c 2@I1'KƧ@(o-Vo d@H^5?|vȴ@*$cb d@HƧ- 7KƧ@,+cg !2@HA7KzG{@-b`Aod1 2@H9XbN33333@.w+od2 @I$/TE@$33333n d@J;dZGzH@# =pca d@Jr I^5zG{@!;lCc 2@JQ.zG@Z1o d@JA$/I^5?@#cb d@J/vI^5?}@&c =pcg1 d@Ij~#o@!$cg2 @J1' M@ u?|hn d@JI+ Q@+ca d@JGKƧ`A7K@1&c 2 @JA$/@o d!@I|hs GzH@XbMcb 2"@I%`A7LVt@O;og1 d#@I+ Iu\(@+ Jcg2 $@JI7KƧ1&@ n d%@JPěT?@!vȴ9ca d&@IA7K?tj~@ Z1c 2'@IC@Vt@ 7+o (@I^5?|?ꟾvȴ9@ En d)@HwO;d?/w@Rca d*@Ghr!?5?|h@"$/c 2+@GStj~?$/@!ffffffo d,@H7lC?333333@w+cb 2-@H49XbNC$@bMog1 d.@H`A7? =p @cg2 /@H"M?A7Kƨ@$Qn d0@Gt?-V@&Qca d1@Ge?|h@|hr@' C%c 22@FF@ =p@';dZo d3@Gfffff?ꟾvȴ9@)Y+ cb d4@GT/?&x@+cg1 d5@Htj I^5@)0 ěcg2 6@G(\@ + @'A$/n d7@GA7K@y"`@'\(ca d8@Gs33333@tj@%Mc 29@GKƧ@x@$Ձ$/o d:@HCS@nP@)cb d;@H G{@&x@*j~cg !2<@GqGz@tj~@+XbMod1 =@H$/@zG@+`And2 >@Fڟvȴ@7Kƨ@$/wn d?@Fhr@@"Qca d@@E`A@/v@#Yc 2A@E;dZ@)lD@#|hso dB@F/w@ =p @-Vcb 2C@Fl@A7Kƨ@vȴ9og D@ES@zG@#lCn dE@DXbM@ +@$$/ca dF@D["`B@M@#=Ec 2G@C\(@S@$o dH@DG{@# ^5?}@$t9XbNcb dI@E)lD@$n@&dZ1cg1 dJ@Cj~#@#WO;d@$zGcg2 dK@Er Ĝ@$6ȴ9X@)QRcd1 L@DU`A7L@Q@ =p n dM@Cɺ^5?}@A7K@xFca dN@CҰ ě@r Ĝ@^5?|c 2O@CR-V@H9Xb@ 0 =qo dP@C1&@r Ĝ@mhr!cb dQ@Dhr @x@"`Acg dR@D\(@ I^5@.zGcd S@Dnvȴ9X@;dZ@ #Sn dT@DR@^5?|@ Qca dU@DX1&x@Ƨ-@#XbMc 2V@D + ?$/@$MO;dZo dW@E8r Ĝ@ěS@ cb dX@Em-V@-@Lcg dY@F bM@ ě@cd1 dZ@DQ@GzH@tj~cd2 [@D-@  I^5@%$/n d\@D\1&y@ tj~@(ilDca d]@C1&y@ Z1'@(O;dZc 2^@CL(\@hr Ĝ@*Qo d_@D-V@?|h@*J=p cb d`@Ew-@+ I@*+ cg1 da@Dw-@Q@-5\(cg2 db@EdZ@-V@*-Vcd1 c@CSE@=p @'n dd@B;dZ@9XbN@(tca de@B.zG@j~"@&XbMc 2f@A@ I^5?@(C$o dg@BrnO@333333@&ǮzHcb h@BQl@ m@$`A7n di@AQ@C$@#eSca dj@B-?S@$33333c 2k@Ahr?bM@%j~"o dl@Btj@j~#@ ilDcb 2m@BXbM?"`A@ Rog n@B$/?C$@%I^5?n do@BǍO;dާ-@']-Vca dp@B^+?|hs@*1&xc 2q@B$/Vt@*Eo dr@CF333333@'Qcb 2s@C\( =p@)Sog t@Bmhr!?@+Qn du@Btj??|hs@.Eca dv@APn?S@-A7Kc 2w@@$/+ J@/Qo dx@BKS?5?|h@/ڟvȴcb dy@C dZ?(\)@0SEcg1 dz@Aj~#?o@10 =qcg2 d{@CJ=p @ffffff@1tjcd1 |@Ahr ?1&@,En d}@@[dZ?E@+"`Bca d~@@ 1'?1&x@*mhr!c 2@>+tj~@+$Z1o d@@4/@-V@)zGcb d@@QR@"`A@+mhr!cg @? ě@R@.Ƨ-Se d@=^5?|@vȴ@-Qce @@hr Ĝvȴ@(n d@@$SlD@'I^5?ca d@?EE@)Sc 2@>O;dZ =p =@)xFo d@@-V@%r-Vcb 2@A?vȴ95?|h@&ovog @@j~"+ I^@+1&n d@@K"`B9XbM@-ȴ9Xca d@?ix + J@/u\(c 2@>(\kQ@0zGo d@@ExF@/_;dZcb d@A{ I^Gz@-Scg d@B^5?|l@/+Qcd d@B$xF@0\(ce @BS + J@-ěTnz @??;dZ+@0 Qn d@># =p`A7L@0Eca d@<Ƨvȴ9@0!$/c 2@;SS@0$/o d@>P =qm@1]/wcb d@?(\Q@2,I^5?cg d@? I^S@3H\)cd d@>1&yzG{@4hr Ĝce @?%tj@5Cnz @<̋Cn@-j~n d@;vȴ9XQ@, Ƨca d@;L1&y XbM@+A7Kc 2@:$Z1 -V@+vȴ9Xo d@;QVt@)p =qcb d@;S?n@)p =cg1 d@:ƧVt@'DScg2 d@<|hr?Gz@'A7Kcd1 @QC%@1~"n d@7vȴ9-V@2Vuca d@7&xO;dZ@1j~c 2@7^QՁ$/@0+ Io d@9RmQR@2ncb @5"`B+@2IlDn d@5+C%?$/@1^5?}ca d@5"`@ I^5?@1$/c 2@5nP@ O;dZ@0"`Bo d@3m?bM@2bMcb d@2bM^5?|@2LI^5?cg !2@3//v@1E`A7Lod1 2@2:G{;dZ@3Fxod2 @61&@zG@2tjn d@7R-V@ I^5@21&ca d@8n@ \(@3Vc 2@8zG@S@4`o d@6-@Jn@3ܬ1&cb @9^5?|@m@3Sn d@;Q@r Ĝ@3ca d@;+ J@R@4Vc 2@;rnO@kQ@4l1&y@`A7K@6~vȴ9Xc 2@>1&x@n@6Z1o d@vȴ9X@;mca d@G/@1'@:Ec 2@GR\(@-V@: =po @Gj~#@49XbN@91'n d @G-V@ I^5@8p =ca d @GHr Ĝ@?|h@7`A7Kc 2 @G߾vȴ9@]/w@733333o d @F`A@ Y+ @8Ecb  @F=p @TE@6+n d@G9Xb@TE@5&$/ca d@G*vȴ@p =@4lc 2@Ghr@sE@3`Ao d@Fz1'@hr@4|hscb d@F7Kƨ@nP@3 lDcg ad@G.+@B\(@2\)cd1 Vd@F 1'@Ƨ@2'-cd2 ed@GE\(@Ƨ-@1.+ce1 ed@F!$/@-V@0xce2 Vd@Fn@@n@0P =qcz V@Ft@zG@4zGn d@Fo@"d/@3lca d@G/@$H9Xb@4 =qc 2@FC@%@5fffffo d@Fhr @#nzG@3O;cb d@EE@!Ձ$/@2\(cg @FQ@"O;d@0-VSe d@F$/@-V@0 I^ce  @G@$^5?}@4Fn d!@HE@%E@5Eca d"@G =q@(9XbN@5tc 2#@G =p@*+ @7vo d$@H5?|@%"`@5Ecb d%@I"-V@"(\@5`A7Kcg d&@IGO;d@!p ě@6cd d'@Ic33333@Õ$@6p =qce (@I'+ I@ I^@7nPnz )@Gȴ9Xb@*>vȴ9X@4Qn d*@Gx@-;dZ@4/ca d+@F$/@-bM@4nPc 2,@Fm@, @4P ěo d-@G ě@.m@3XbMcb 2.@G+@.M@2/og1 d/@Hvȴ9@.$/@3$/cg2 0@F\(@/ɺ^5?}@5|hsn d1@Ej~#@0G+ I@5Vca d2@EbM@0v+ J@4"`Bc 23@E+C%@0zG@3šo d4@Evȴ9X@1 ě@6["`Bcb d5@E=@29@6mhr!cg d6@D@1:^5?|@6xcd1 d7@EDtj@3qR@7`A7Kcd2 8@Fvȴ9X@1ȴ9X@3@A7Kn d9@E^5?|@1VE@1|hsca d:@EǍO;d@0lC@1"Mc 2;@EDtj@/Ƨ-@0rmo d<@FrnO@21hr @1%Scb d=@F{Ƨ@2x@/;dZcg d>@GQ@27KƧ@.`A7cd !2?@Gn@2"`A@-t9XbNoe1 2@@G =p@4-@-r Ĝoe2 A@F5?|h@.O;d@1YXbMn dB@Fx@+Q@0KƧca dC@EE@)j~#@1KC%c 2D@E*n@(x@0 I^o dE@F\(@)m@0ěTcb dF@G>zG@*և+ J@/&xcg !2G@G\)@,{dZ@-j~#od1 2H@GΗO;@*-@0Qod2 I@Ejvȴ@*#S@21&n dJ@D`A7L@(޸Q@3D/ca dK@D/v@*zG@2tjc 2L@CzG@(lC@2|1&o dM@D&x@)"`B@4\(cb N@D)XbM@,Q@2Qn dO@C@.hr @25?|ca dP@ClI^5?@-I7KƧ@0-Vc 2Q@Bt@,A7K@0\j~#o dR@CG{@0@2*~"cb dS@C&x@1|hs@3zGcg dT@C\(@2S@3+cd !2U@C&x@3XQ@32moe1 2V@D&+ J@3 @3"`Boe2 W@C ě@-!Gz@/hrn dX@CƧ@,xQ@,Sca dY@CƧ@)F@,xc 2Z@C =p@)Y+ @+Qo d[@Dhr!@,Ƨ@+Y+ cb \@C|hs@'t@.49XbNn d]@CzG@%1&@.+Qca d^@B$/@%$/@/C$c 2_@Bi^5?}@#dZ@.o d`@DbM@#CnP@/7KƧcb da@CV@ QR@/Qcg db@Cp =@XbM@-7Kƨcd1 dc@D+ I^@+ I^@0Mcd2 d@B-V@&]/w@0j~#n de@BnP@&TE@1LI^5?ca df@A{dZ@'aGz@0QRc 2g@@bM@&0 ě@0.O;o dh@A\)@'O;@2Scb i@AƧ@)\(@/zG{n dj@A$j~@*/@-Rca dk@A @(G{@+.O;c 2l@@}V@($/@*5?|ho dm@AfE@-x@,Scb dn@AKQ@/׍O;d@.xcg o@@(\@0b`A@/Ynd1 dp@A@09Xb@0\)cd2 dq@@Ƨ@1Z^5?|@0&xce1 !r@A`@11&x@0+ne2 !s@A I^@'$/@*B I^5n dt@A =p@%"@'`A7Lca du@Avȴ@#Q@(nPc 2v@@C%@"lC@&Co dw@BE\(@% =p @'\(cb x@A%S@"-@*Qn dy@@tj@ C$@+~"ca dz@??|h@!zG@,O;dc 2{@? Q@49XbN@+Vto d|@@F@=p @. 7KƧcb d}@A@tj@-N+cg ~@A\(@r Ĝ@0 Se d@BAGz@Y+ @1E`A7Lce @?n@#{dZ@-;dZn d@>nO;@$-@- =pca d@=$/@$޸Q@*߾vȴ9c 2@pbM@'%`A7L@/QRcb d@=+ J@(KƧ@/`A7cg1 d@>~"@&-@1!$/cg2 @>wO;d@% =p@(lDn d@=n@&TE@&J=p ca d@=^5?}@#l@$Vc 2@ =p@'Z1@$|j~#cb d@>vȴ9@*7Kƨ@%TEcg d@?Gz@,$@#nOcd @@aR@+^5?}@!^5?|ne d@@-V@+׍O;d@"dZcz @AC%@--V@%b\(@!-V@%9"`n d@>+@tj@$%Sca d@<n@O;@%TzGc 2@;?|h@1&@#ؓtjo d@?4E@+ I@$nPcb d@@4E@$/@"lCcg1 d@>1'@-V@# =qcg2 d@@ I^@j~"@#w+cd1 @Qhr @&9"`@5+C%n d@?-@% ě@5Vuca d@@ @'5?|@6$/c 2@?vȴ9X@)-V@6-Vo d@@WlC@%`A7@4vcb @@t@&-V@7ěTn d@@|hs@(5?|o d@CS@%@ȴ9Xo d@EI7KƧ@* ěT@>Scb d@Fl@+$/@>O;dcg !2@F!&x@,@=7KƧod1 2@FnO;@)ܬ1&@?Ovod2 @E-@$9XbN@=g+ In d@FUS@"?|hs@=šca d@G+ I@"\(@=7KƧc 2@G1&x@!u\(@=;dZo d@F=-V@ tj@9XbNSe d@Fhtj@nO@>׍O;dce @G;S@%E@>z^5?|n d@GO;dZ@%zG@> =pca d@H%$/@$q&x@@zHc 2 @H-@$\(@@Rmo d @H$@( ě@?fffffcb d @HGz@*O;dZ@=zHcg !2 @Hp =@)߾vȴ9@@FE333333@B^5?}cb d?@F1&?̋C%@BScg1 d@@G$tj\(@AO;dZcg2 dA@GXF?zG@C9XbNcd1 B@EdZ$/@B+ In dC@EۥSB\(@BEca dD@E.vȴ9Xvȴ9X@B =pc 2E@DڟvȴE@BE\(o F@Dhr!+@Cfffffn dG@DaGzQ@BƧca dH@Cvȴ9XnO;@Cq7Kƨc 2I@CovbM@CrnOo dJ@Dtj~"v@BMcb dK@E&x"t@B ěcg !2L@D&x!ڟvȴ@AxFod1 M@E/#;lC@B End2 N@CVu!ix@C$n dO@C =p!0 =q@Dnca dP@C-š@Dؓtjc 2Q@Chr!+ I@EQo dR@CnO#g-@E"cb S@D2nOhr @Dؓtjn dT@DLO;d@EC%ca dU@CA7Kx@Dšc 2V@Cl /v@E I^o dW@E1&xnO@E I^5?cb dX@E/n@Ey7KƧcg dY@F@l@E; I^cd1 dZ@Ep =qȴ9Xb@F9+ cd2 [@C|hsS@DVn d\@C_\( nO;@Cvȴ9Xca d]@Btj~ Z1'@C/wc 2^@B=O;dZE@Cݲ-Vo d_@C=p 9XbM@B-Vcb d`@D>"lC@Bhr cg da@Dj1' ě@B$/cd !2b@C7KƧěS@A̋Coe1 2c@D"`BC$@A陙oe2 d@Br I^5lD@Cmn de@AEr Ĝ@D&xca df@A+ ^5?|@D/c 2g@A 1&Q@D陙o dh@AQ@D ěTcb di@AKƧw+@DQ$/cg dj@@r\(TE@C-Vcd1 dk@A O;dZ!"`B@DI"`cd2 l@Bvȴ9Xhr @ESnPn dm@A I^5 =p@EXbMcaadn@AlE@EXbMcabdo@ASzG@E7Kƨc !2p@AaGzzG@F/;dZo dq@B7KƧ{lC@FuQcbadr@B$/|hr@FwzHcbbds@B$ vȴ@G ěcgadt@BGz&x@F-Vcgbdu@Ar Ĝ ffffff@Gocda!dv@C&x I^@G`A7cdb!2w@BZ1+@GSoe1a2x@CVuj~#@Foe1by@A^5?|E@Gne2az@B1' I^5@GSne2b{@BA7KƨS@ExQn d|@B*~"ѿٙ@EP ěca d}@Ahr ſȴ9Xb@Dc 2~@A2`A? I^5?@Eo d@B;dZ?vȴ9X@D$/cb d@BO;?$/@D\(cg d@CilD?zG@DeScd !2@C"`?7KƧ@DRoe1 2@Cttj@nP@CXbMoe2 @ALI^5?Vt@D|hsn d@@ ě5?|h@D.vȴ9Xca d@@MzG@D9XbNc 2@?:G{Q@Dno d@@lChr!@Cvȴ9cb @@5?|푿+ @E,j~#n d@?E`A7LGz@E\(ca d@?;"`BnP@F!lc 2@> ntj~@FH1&xo d@?Z1 ě@F!lcb d@?4zGěS@EzHcg1 d@>n Q@FƧ-cg2 d@?zG =p @E|hscd1 @@2 I^5j~"@FN5?|n d@@6-?A7Kƨ@F;dZca d@?-V@bM@FO\(c 2@>;dZ@\(@F^5?}o d@@A7K?/w@F/cb d@AC$?tj~@G` ěcg !2@@^5?}?7KƧ@Gfffffod1 2@AGz?lC@GW+od2 @@@Vu@E1&xn d@?v+ J@ hr @EFS@H;dZnz @

'+ I@E@GY"`o  @>"`B@p =q@GEn d @@ C@KƧ@GěTca d @@dZ@nO;@G-c 2 @A-p =@@GZG{o d @@ ě@lD@HEcb d @>\(@9XbM@H{lCcg d @>/@ nP@H9Xbcd !2 @?dZ@x@Hoe1  @=tj@xF@ImVne2  @@m@aGz@Fo;dZn d @A4j~@!o@F9XbNca d @AzG@E@E =pc 2 @A-V@["`B@F"\(o  @B7O;d@1'@Etn d @B\)@Z1'@E_;dZca d @BJ1'@ S@EMc 2 @AQ@ nzG@Dr Ĝo d @C0`A7@5?|@D/wcb d @C)lD@ =q@EEcg d @Br ě@ =p@E6xcd  @B{S@#XbM@E#Sn d @B$/@%vȴ@DQca d @B2-V@%M@DQc 2 @Aȴ9X@&;lC@Co d @Bl(\@(A$/@E/wcb d @BilD@(=p @E`A7Lcg d @AKƧ@("`@F+ I^cd d @A =p@)y"`@FEce  @Ahr@' O;dZ@G["`Bnz  @BǍO;d@% I^5@CC%n d @B@$ ě@Cnca d @Bo\(@"@B-c 2 @B 1&y@#eS@BAhr o d @CěT@$Ƨ-@B`Acb d @C-@"$Z1@C\(cg !2 @CVu@ j~#@Chrod1 2 @D{dZ@!@B\(od2 @B}-V@ TzG@Bmn d@B =q@}E@B9XbNca d@ASnP@~"@B ěc 2@@E@Y+ @BB-Vo d@B5S@`A7K@C;dZcb d@At@;dZ@Bϝ-Vcg d@A\(@hr Ĝ@B$/cd1 d@Ahr@ XbM@CC$cd2 @A/w@ vȴ@CPěTn d@@j1'@ ȴ9X@CdEca d@@3 =p@# I^5?@BVc 2@?W+@"I^5?@BI^5?o d@@KlC@!j~@DzGcb 2@@ylD@1&@DZ1og1 d@?&x@"Ձ$/@D:^5?|cg2 @@1&@%@B33333n d@@u@'(r Ĝ@BF+ Jca d@@nQ@&`A7@A-Vc 2@?-V@&n@A-/wo d@@ =p@)tj@BRMcb d@@"`@+ȴ9X@Avȴ9Xcg d@@,I^5?@-)lD@A^5?|cd !2@?+ J@-)lD@BdSoe1 2@?\(@.U$/@AV+ Joe2 @@t@$MO;dZ@AaRn d@@ ě@##S@@Z1ca d@@A7Kƨ@!h\)@@^5?|c 2@?KƧ@!Gz@@zGo d@A~5?|@!p ě@@A7Kcb d@AM@ U$/@?-Vcg d@A$/@"M@>+ Icd1 d@B4E@(\)@?9Xbcd2 @@@o-V@A+n d@>1&@DS@A+ ca d@=@@@+c 2@<7Kƨ@n@@vȴ9o d@>ۥS@+ @Aocb d@=p`A7@bM@AlCcg1 d@?zG@$/@A =qcg2 @=hr @!9XbN@Ag+ In d@U\(c 2 @R@(@?2mcb 2@?@A7K@*vȴ9X@@og1 d@? lD@)ڟvȴ@=tj~cg2 @=o@#R@>NzGn d@=ov@! =p@=Ffffffca d@<n@ E@=wKƧc 2@;ES@Q@<tjo d@>nVu@ I^5@=[Scb d@?"@7KƧ@9XbNn d@:@ěT@1&x@? xca d@949XbN@ tj~@>c 2@8.zG@bM@>Eo @9tj~@#,C@>5?|n d@8@%;dZ@>z^5?|ca d@8J~"@%7+@ocb 2!@8j~#@(G+ I@@'+ Iog "@9[dZ@$M@<1Rn d#@9/-V@$ =q@:+ ca d$@8Z1'@"49XbN@:\(\c 2%@7{lC@";lC@9v+ Jo d&@:I^5?@$+ @:A7Kcb d'@;R-V@'J=p @91&cg d(@<-@'@n@8lCcd !2)@=*~"@%,1&y@8lDoe1 *@<1&x@)bM@8P =qne2 +@8;dZ@ -@;vn d,@7l@tj~@:Eca d-@6n+@ =p@:G{c 2.@5Q@ 7KƧ@:# =po d/@8m@r ě@;n+cb d0@:fffff@`A@; ~"cg 1@:?|h@'-@<+ƧSe d2@:+ I@tj@;/wce 3@6@1&@<Sn d4@4E@(\@@4\(@'F@9\(cb d?@4"`A@)nzG@8KƧcg1 d@@4\)@)Rm@;>"cg2 A@4+ I@"XbM@8LCn dB@4+ J@ &x@7Eca dC@3"@1&x@7'-c 2D@3-@dZ@6!$/o dE@633333@+ @6+cb dF@7zG@!S@6cg dG@8xQ@ (\@5j~#cd1 dH@6z1'@"`A7@4cd2 I@3U$/@@8Z^5?|n dJ@2VE@|hs@8xca dK@0tj~@-V@8oc 2L@0$/@e`A7L@9xo dM@2E@"`@9zGcb N@0E@u\(@8|hsn dO@/(\)@ (\@8vca dP@.9Xb@ )lD@:+Ƨc 2Q@+@ C%@:XQo dR@-# =p@@7mcb dS@.# =p@ zG@6V+ Jcg !2T@/d/@"ěS@60 ěod1 U@-bM@vȴ@5U$/nd2 V@/C%@ `A7@;+C%n dW@.;dZ@ 1&@xbMo dZ@0\(@Vu@=T9XbNcb d[@.$/@+ J@Mcb d!@/`A7L@+M@<on de!@0lC@-l@:j~#ca df!@1dtj@/bM@:tc 2g!@1+@0hr@97KƧo dh!@- =p@0M@;9+ cb di!@++ I@.zG@;*=p cg dj!@*vȴ@-C$@9㕁$cd !2k!@*r Ĝ@.{dZ@8Voe1 2l!@*`A7@*I^5?@9vȴoe2 m"@2 1&y@/vȴ@<lCn dn"@3Q&x@0lC@<6tca do"@4]/w@/|j~#@<;dZc 2p"@4 x@-KƧ@=ǮzHo dq"@3?|h@1F@H\)og1 ds"@2S@2vȴ9X@rnOoe1 2%@,vȴ9Xca d2@4;"`B?+ I^@D+c 22@4&fffff/w@D =qo d2@2*n?"`B@DXbMcb 3@5F$/?lC@D\(n d3@6h\)? =p@DG+ Ica d3@7G{䛥S@DEc 23@7d/Gz@D%Qo d3@7ilD?r ě@D?-Vcb 4@7b I^5m@E,j~#n d4@8 n\(\@Ew+ Ica d4@7$/o@EqGzc 24@7ěTp =@EPno d4@8x@F/;dZcb d4@9cnPnO;@FylDcg d4@:&xM@F9cd1 d4@9^vȴ9X"`@G>O;cd2 5@5ؓtj$/@Evȴ9n d5@4r Ĝ+ @E$ca d5@4`A7Z1'@DRc 25@4$'-@Dvo d5@3tj M@E33333cb d5@3f$/ 1&x@F-Vcg d5@3/wtj~@Flcd !25@3i^5?}hr @Ftjoe1 25@4ȴ9Xl@Gffffffoe2 6@41&x -V@D`n d6@4n`A7@C-Vca d 6@6#S.zG@C7KƧc 2 6@6 O;dZ.zG@C0bMo d 6@4\(1&x@C81&xcb d 6@4`A KƧ@Bz^5?|cg d 6@39XblC@B9^5?}cd d 6@2Jn @B7O;dce  6@1\(Q@B--Vnz  7@7KƧ$/@Cn d 7@8\(V@C"`Bca d 7@8U\(Jn@Dtjc 2 7@8O;dZ8Q@C =qo d 7@9 ě`A7@DKƧcb d 7@;-F@C͑hr!cg ad 7@;>5?|+ J@C'+cd1 Vd 7@<EGzH@D>O;cd2 ed 7@<{lCw+@BEce1 ed 7@=QR1&@D (\ce2 Vd 7@=9XbE@Ck I^cz V 8@71' =p@Dvȴn d 8@7o\( eS@D I^ca d 8@6""`A@D;dZc 2 8@6S$m@Dl1&o d 8@6Ձ$/+@EzGcb d 8@7bM)lD@F"mcg d 8@7/;dZ2-V@Fhrcd d 8@6r ě [S@G(bMce  8@5nODS@GzGnz  9@5u\( r Ĝ@D9^5?}n d 9@4A7K"Y+ @C^5?|ca d 9@54j~#j~"@C-hr!c 2 9@5 %G{@BQo d 9@3SE zH@C;dZcb 2 9@2Vu1&@D!Rog1 d !9@2g-"Q@C(\cg2  ":@6fffff!dZ@BSn d #:@6G{"{lC@BNQca d $:@77Kƨ$S@BrnOc 2 %:@7+ J&"`B@B =po d &:@7 =q \(@B9Xbcb d ':@8+ 9XbN@Acg ad (:@8;dZ!=p @AQcd1 Vd ):@: A7K MO;dZ@A1&xcd2 ed *:@9^5?|"ilD@@bMce1 ed +:@;.O; Ձ$/@Ak I^ce2 Vd ,:@:O;dZ!x@@"`cz V -;@8$hr@BEn d .;@9jn&Z1@C4tjca d /;@8|hs){lC@C\c 2 0;@8-V+fffff@CVo d 1;@:EQ%S@CУ =qcb d 2;@;S33333#O;dZ@CbMcg1 d 3;@:1&y(.O;@D0 ěcg2 d 4;@=@5V+_;dZ@Bnn d ?=@4l,nO;@BE\(ca d @=@5zG-1&y@A+c 2 A=@5{lC/["`B@A^5?|o d B=@4D/* ěT@A߾vȴ9cb d C=@2-V)8F@B,1&cg !2 D=@2glC*nP@Bxod1  E=@2l&\(@AbMnd2  F>@7=E-@ASn d G>@89/ @Ahr ca d H>@9!Gz0ao@AEc 2 I>@:R-V0l@AЃno d J>@9/-(\)@A xcb d K>@8-V,$@@j^5?|cg d L>@8Ұ ě*Q@?Gzcd !2 M>@8DS(=p @?tj~oe1  N>@91&+`A7K@?[dZne2  O?@87KƧ0x@B}p =n d P?@9&-1Q@Bmca d Q?@: =p1`A@Cu?|hc 2 R?@:qhr 2Stj~@CI^5?o  S@@:G+ I06ȴ9X@C33333n d T@@;1R/$/@D-ca d U@@:m/r-V@DlDc 2 V@@9]-V/H1&x@Dj~#o  WA@;lI^5?/t@E =p"zG@GZ1o d sD@>+ (zG@G+ Icb d tD@@zH&O;dZ@F"`cg1 d uD@>hr *^5?|@GG =pcg2  vE@<š"O;d@G7Kƨn d wE@<Vr ě@FƧca d xE@x vȴ9X@Id/ca d G@?͑hr!!Z1'@HC%c 2 G@@3 =p#\(@HlCo d G@>5\(#W =p@I-cb d G@=R"7Kƨ@JMEcg  G@; ě#1'@J89Xbnd1 d G@<1'!zH@JnPcd2 d G@;o"`A7L@JA7Kce1 ! G@;\(!)x@K5?|ne2 ! H@@V`A7K@H^5?}n d H@@^5?|$/@H.5?|ca d H@AV+ J P`A7@H{Qc 2 H@A˅Q hr@HG{o d H@@E@Gѩlcb d H@@i+ zG@HR I^5cg d H@?vȴn@Hj~#cd  I@AdzG 3E@I&$/n d I@A!&fffff@I\(ca d I@BS$# =p@Ic33333c 2 I@Btj%vȴ9@I}-Vo d I@A陙 C%@JDzGcb d I@ATE!"`@JFcg d I@@V mhr!@JƧcd !2 I@@bM'-@JDzGoe1 2 I@@9lD! =p @K-oe2  J@Al%n@I$Sn d J@AbM(l1&y@HQca d J@A\((E@HDEc 2 J@Ax+>vȴ9X@HnPo d J@@)E@IzGcb d J@@1&y)A$/@IQcg d J@?-*(\)@I-Vcd  J@?Qhr )TE@June d J@>x)@J-Vcz  J@=#$*@J+ I^nh1  J@="(Vu@K89Xbnh2  K@A(\&ܬ1&@Ghr n d K@BGzH'3E@G8r Ĝca d K@Bvȴ9X(["`B@GJnc 2 K@CGO;d(.zG@Gfffffo d K@BKdZ$=p @F=p cb d K@AěT#o@Fvcg d K@A`A ׍O;d@FU\(cd1 d K@Ao\(%k I^@E I^cd2  L@CD9XbN)E@FO;n d L@C+ I*vȴ9@F+ca d L@DqGz(vE@FO;dc 2 L@Dhr Ĝ&LI^5?@F/o d L@D =p+ =p@Etcb d L@Ch1&x+E@Ecg d L@B =p*.O;@F1&ycd  M@D=p )!Gz@Gu$/n d M@EUS'RnO@Gɺ^5?}ca d M@F O;dZ(XbM@GGzc 2 M@F-/w*ɺ^5?}@GEo d M@E+dZ'B I^5@Htjcb d M@Dw-&bM@HI^5?cg d M@DdE# @H{Scd !2 M@C-"0 ě@H$j~oe1  M@DbM!p =q@H$/ne2  N@F ě&+ J@Gon d N@G3S'ix@G^zGca d N@GE(\(@H c 2 N@GdzG&tj@Ho d N@G^5?|%&fffff@G`Acb  O@G;dZ*9Xb@HRn d O@HKƧ*p =@HlCca d O@H-(}p =@H =pc 2 O@H`A7(A$/@Io d O@H1&x,"`@Hncb d O@H|j~#/Q@Hlhrcg d O@I\)0;dZ@HHbMcd !2 O@I!Gz1?vȴ9@Gtj~oe1  O@IkQ15?|@HG{ne2  P@I "`B& ě@Htn d P@It$x@HO;dZca d P@IP`A7"bM@Htj~c 2 P@I9^5?}!;dZ@G^5?}o d P@J\@J lD@&~"@Dixcg1 d ?\@J6E@&lC@EGzcg2  @]@J;dZ@,$/@CzGn d A]@J"@-@C8r Ĝca d B]@Jv@+`A7@B~"c 2 C]@Jj~@,Ձ$/@BEo d D]@Klhr@/PbM@Cncb 2 E]@Lfffff@- ě@C~"og1 d F]@Kq&x@0XbM@C-cg2  G^@J/@)Dtj@Bn d H^@J I^5@'wKƧ@BMcaad I^@J7KƧ@'9Xb@Bcabd J^@J9XbN@$x@BIxc !2 K^@K vȴ@#j~@Br Ĝo d L^@K =p@'GzH@A7Kƨcbad M^@KQ@'š@AƧcbbd N^@K+@%bM@A^5?}cgad O^@K/w@*n@A_vcgbd P^@LR-V@&/v@@vȴ9Xcda!d Q^@LI^5?}@+:G{@@/wcdb!2 R^@L"@(+ I^@@moe1a2 S^@LWO;d@)E@@e$/oe1b2 T^@L{"`B@$zG{@@TZ1oe2a2 U^@LS@,E@Atjoe2b V_@JP@#`A7K@Ap =n d W_@J."@ S@B+ Jca d X_@J#$@o@AT/c 2 Y_@I33333@vȴ9X@@9Xbo d Z_@IKƧ@ =p @Bg+ Icb d [_@I{dZ@ `A7L@C"`Acg d \_@H5?|@ \(@CkQcd1 d ]_@IR@`A7K@Cvȴ9cd2  ^`@J$@v@AVn d _`@J9Xb@|hs@@mp =ca d ``@J;dZ@lC@@g-c 2 a`@JR`A@9XbN@@nPo d b`@KH9Xb@bM@@&Ecb d c`@K9XbM@KƧ@>zGcg1 d d`@KG{@H9Xb@@6fffffcg2  ea@IQ@+@@\(n d fa@Hr Ĝ@nP@@" ěca d ga@I)lD@ QR@?A7Kc 2 ha@I -V@QR@@2 ěo d ia@HaGz@`A7L@?lI^5?cb 2 ja@H)+ @|hs@?Mog  kb@Ivfffff@ Q@>+n d lb@IS?hr Ĝ@=`A7ca d mb@J I^5? ě@>vȴ9c 2 nb@JE/w@>lCo d ob@Iȓtj?\(@`A7cg !2 yc@KE?\(\@=tjod1 2 zc@LA7K@~"@>Qod2  {d@JX1&x?Q@A =p n d |d@I-?+ I^@A"ca d }d@Ij~#|hr@Aic 2 ~d@Il-V@AEo d d@I+?$/@Atj~cb d d@J j~#@bM@B4Z1cg1 d d@I =p?ěS@Bhr cg2 d d@Ir Ĝ@\(@B^Vucd1  e@IA$/ۥS@@ϝ-Vn d e@HlCxF@@lDca d e@IYx$/@@pc 2 e@I(9XbzG{@@vo  f@I\(;dZ@@%Sn d f@Jl1& 7KƧ@@lCca d f@Jnvȴ9@@ɺ^5?}c 2 f@J+ I@@ݲ-Vo d f@K ě Q@?lI^5?cb d f@KC%$/@?\hrcg1 d f@JVuzG@=p =cg2  g@J+ I^5?}@AGO;dn d g@JQvȴ9X@ASca d g@JV+ Jj~@B;lCc 2 g@Jvȴ9XsE@Bzvȴo d g@J;dZlC@BkƧcb  h@I+ I# =p@B+lCn d h@I&ȴ9XsE@BdzGca d h@I|hsȴ9Xb@Boc 2 h@I $/@BMp =o d h@H|hsu\(@BTZ1cb 2 h@GS I^@BdZog  i@I2m$/@AXFn d i@I2mC$@@A7Kca d i@Ivȴ!"M@A)c 2 i@I1&#n@A'-o d i@IO|hs-V@@4tjcb d i@IC {lC@?lCcg  i@Im&x@=p =Se d i@IZ^5?|B\(@=["`Bce  j@JPA7K $/@AZ=p n d j@J޸Q!5?|@A1&ca d j@J/w#\(\@B3$c 2 j@Kvȴ9%Z1'@BTSo d j@KE Dtj@AdZcb d j@K?|h"`@@O;cg  j@LƧ=p =@Ahr Se d j@M I^]/w@@>Vuce  k@JC33333"ffffff@Bxn d k@JO;d#׍O;d@C5?|hca d k@I33333&-hr!@C XbMc 2 k@Ir`A'Gz@Cw+ Io d k@I =p!(\@CI^5?cb d k@JbM8Q@C9XbNcg d k@II^5?hr!@D@ =qcd1 d k@JěT hr@Dzncd2  l@IN5?|&.O;@BkdZn d l@HZ1(.O;@B.5?|ca d l@H#E'bM@B\(c 2 l@G|hs(vȴ@A|hso  m@HQ$eS@A"n d m@Gf+ J#2-V@AnPca d m@G&E#}E@A)c 2 m@F/w#I^5?}@A 1&yo d m@Ghtj 0 ě@B\(cb  n@GzH#fffff@@/wn d n@G`n$(\)@? ěca d n@Gt&&x@?\(c 2 n@HG+ I'>"@?`A7Lo  o@G&$/@=ۥSn d o@GЃn(\(@+'ilD@;׍O;dc 2 o@HM%ao@;VEnh1  o@E%`A7L*zG@=BMnh2  p@Hʟvȴ(ؓtj@;1&xn d p@I&-(nP@:=-Vca d p@HҰ ě*2 ě@9 nc 2 p@HS)1l@8fffffo d p@IKƧ)8Q@:["`Bcb d p@Jqo'nP@:xQcg d p@Khr!(O;d@9zGcd1 d p@JC33333$TE@9+ Icd2  q@Hhr ,E@9ilDn d q@H\I^5?.}E@8b\(ca d q@GV/ I^5@8\)c 2 q@GE/~"@9+ o d q@H?|h0w+@8'zHcb 2 q@H\(1tj~@9A7Kog1 d q@Im0R@8nVucg2  r@GDtj0"\(@7ѩln d r@FQ0-V@8&fffffca d r@F~"1zH@9^5?|c 2 r@F.Vu2F-@9o d r@F9lD1+ J@6$/cb d r@E|C1sE@7^5?|cg d r@EZ11Q&x@5cd d r@DvE2@ěT@5Mce  r@Dk"`B3+ I@4rnOnz  s@GBM2Gz@9'-n d s@G]E3\)@:/ca d s@G\)3V+ J@;u\(c 2 s@G`A7L49XbM@ =p c 2 t@F5?|1h1&x@=p =o d t@HXbM0Z1'@=XbMcb d t@I$/0s@zGcd1  w@FE,tj@B[dZn d w@F=p ,C@CGzca d w@FB\(*@C:1'c 2 w@Frm(8Q@C&fffffo d w@GgKƧ,XbM@ClI^5?cb d w@GZvȴ--V@D-p =cg !2 w@FθQ,O;dZ@DwzHod1 2 w@GVu-XbM@Dz^5?|od2  x@ES+B I^5@CnzGn d x@E!R)7KƧ@CFca d x@E='q&x@D(Fc 2 x@D|hs%Stj~@D4So d x@DpA7K*I^5?@C\(cb d x@D8\)+zG@B-cg d x@CzH, I^@Ctjcd1 d x@DAo* @BCEcd2  y@Ev(NVu@Dp =n d y@EV'nO@ECEca d y@FPbM$և+ J@E=hr!c 2 y@FZ^5?|#S@Eȴ9Xo d y@F 7KƧ)=p =@EQcb  z@FC$ȴ9Xb@Dfffffn d z@GV-#9"`@DFca d z@G<1& $/@D`A7Kc 2 z@F;dZ O;dZ@D$/o d z@GěT$S@Dpcb d z@H C%'QR@Dp =cg1 d z@GěT$E@C-cg2  {@Gtjp =q@DA7Kn d {@GěT0 ě@D1Gzca d {@H&x;dZ@DdZc 2 !{@H^Q1&x@ERo  "|@GQ ěS@Dn5?|n d #|@HQ333333@D5?|ca d $|@G9XbN7KƧ@D"`c 2 %|@G ^5?|l@DO;dZo d &|@HA7KǿGz@D@Gҏ\(@ p =q@GěTcg !2 ?@GA&x@ffffff@G"`od1  @@H[ I^@lD@H"Mnd2  A@GXbM@`A7@Ftjn d B@H^5?|@!G{@FU\(ca d C@H9XbN@!G{@Ej~c 2 D@H6$/@ $/@E5?|ho d E@HnO@"S@Ftjcb d F@I@"zG@G@cg d G@H-@$A7K@G5?|cd d H@H܋C@$O;d@He\(ce  I@HqGz@&S@HޗO;nz  J@G5?|@$=E@EZnn d K@G(\@$;dZ@Dca d L@Hm@'Ƨ@Dc 2 M@H;"`B@( =p@DVuo d N@FS@%tj@Dv$/cb d O@F}V@"E@D$/cg d P@F$/@ 'lC@DPA7Kcd d Q@F+ J@ 49XbN@C1&yce  R@EE@ kQ@CO|hsnz  S@Hhr @(I7KƧ@C =qn d T@Hl@*9XbN@CQca d U@Hv@-+ J@D /wc 2 V@Gtj~@-[S@DQo d W@Hl@+1l@BbMcb d X@H I^5@(-V@B+ cg1 d Y@Htj~@-XbM@BbMcg2 d Z@H܋C@):^5?|@Amcd1  [@HI^5?@.R@DdSn d \@HXbM@0M@DEca d ]@H=/w@0E@EnPc 2 ^@H&+ J@18bM@Eto  _@HB\(@.$/@Etjn d `@H:G{@-aGz@Flj~#ca d a@HF@-7Kƨ@FRc 2 b@IpbM@,ۥS@F~"o d c@H\(@*vE@Ftcb d d@GG+ I@) ě@F[dZcg !2 e@F@+O;dZ@FD/od1 2 f@GE@'1&@FR`Aod2  g@H㕁$@.O;@GYlDn d h@Iyx@/S@G"`Bca d i@I ě@,]-V@Hvc 2 j@IE?|h@*-V@H:vȴo d k@ILj~#@0t9XbN@Haocb d l@Itj@05?|@Hp =cg d m@I\)@29XbM@I =qcd d n@IqR@2S@I|hsce  o@I$/@1 ě@J^Vunz  p@JWKƧ@++@Hvȴn d q@J =p@)|hs@H\(\ca d r@KC$@*0 =q@HZ1c 2 s@KO;dZ@,# =p@HSo d t@JQ@'ql@G"`cb d u@KTS@(N+@GZ1'cg1 d v@JlC@$o@Htj~cg2  w@K\1&@(nO@IT/n d x@KlD@)5\(@I-caad y@KS@)zG@IMcabd z@Ln5?|@&Vu@I+c !2 {@L2 I^5@$^5?}@Iz=p o d |@Kؓtj@)v@Ju$/cbad }@Kx@(lC@J ěcbbd ~@Kn@,b`A@JScgad @K)@* C%@Jtcgbd @K+ @.ٙ@JKƧcda!d @K?;dZ@*l@K/cdb!2 @L[dZ@/j~@JqRoe1a2 @KƧ@)\)@Koe1b2 @Kk"`B@/|hs@I&xoe2a2 @J1&x@,I7KƧ@K7KƧoe2b @M$/@'G+ I@IEn d @M-V@%@I1'ca d @M\@"-@J)xc 2 @M0A7K@#}p =@Jvȴ9Xo d @NIx@&bM@IzGcb d @NC%@#@Ivcg d @ObM@$bM@Ivȴ9Xcd !2 @O-@'I7KƧ@J`A7oe1 2 @O-@#'-@JMoe2  @MWlC@ ilD@IVun d @M!&x@aGz@J\hrca d @Lb-V@'-@J`bMc 2 @L2nO@Q@J9XbNo  @K/@ ě@JVn d @K9"`@KƧ@JA7Kca d @K$/@hr@Iu\(c 2 @Kq$/@F-@H$o d @JlD@!@I$/cb d @JS@!~vȴ9X@IC%cg d @I7Kƨ@$B\(@Ihr!cd !2 @J"`B@&H9Xb@IMoe1 2 @I"M@$ov@Joe2  @J;dZ@ǮzH@I7Kƨn d @J^vȴ9X@ ě@HVca d @JF@p =@H\Cc 2 @I-V@ěS@Hd/o d @I+@9XbM@IA&xcb 2 @I ě@E@Hj~#og  @Jo-V@tj@G1&yn d @J,@o@G'lCca d @IS@v@F9Xbc 2 @I-O;dZ@5?|h@F-Vo d @J I^@(\)@F7Kƨcb d @K<(\@1&@FzHcg d @Kfffff@V@FJ=p cd1 d @Jp =@ mhr!@F`Acd2  @IbM@ Q@Ghr n d @IGzH@Q@F I^ca d @Ijvȴ?GzH@G*nc 2 @Iv?E@Go d @InVu@j~#@F Scb d @J$tj? =p @EԛScg d @J81&x?QR@Eڟvȴcd1 d @JP@-V@E$Z1cd2  @Htj~?tj@G^5?}n d @Itj~vȴ9X@G_\(ca d @I xo@Ftj~c 2 @HxE@Fbmo d @HgzH$/@Gcb 2 @H^zGݑhr @HU?|hog1 d @Hy^5?}l@H%$/cg2  @I9Xb~"@F;dZn d @IR1&y@Fjnca d @IMO;dZ$/@Fȴ9Xc 2 @Iw+ Ihr @GGzHo d @Ja7KƨnP@FU?|hcb d @JzG o@Fxcg1 d @Jw+C$@Encg2 d @KbM ?|hs@Ftcd1  @HԼj~`A7@FXFn d @H{Ƨ-V@F;dZca d @HKƧ O;@F-Ec 2 @H+ I!@Eo d @G I^+ I^@FjG{cb d @Gc33333bM@Ffffffcg  @F\)e`A7L@G]Vnd1 d @GgKƧo@F$/cd2 d @FěTE@Gtce1 ! @G =qƧ@GR ěne2 ! @I-"S@F =pn d @IE$}E@F/;dZca d @Ib ě'$/@FSc 2 @IE\('DS@G!hr o d @JH\)#v@F0 ěcb 2 @J1'&@Exog  @IeS)>vȴ9X@F"`Bn d @Idtj,$@F\j~#ca d @J-V+ J@FVtc 2 @J&fffff/XbM@FylDo d @Hl-C@Encb d @H/\(-u?|h@FC =pcg !2 @H-$/@Fߝ-Vod1  @G(\-\(@EՁ$/nd2  @Jj~+Q@F-n d @KHF,"`B@F:1'ca d @Kvȴ9*l@FCc 2 @Kv(E@Fhro d @Kfffff,Gz@EScb d @KGlC. ě@E "`Bcg d @KS./@D` ěcd  @KVu,,C@DO;dne d @Ko-V*"@CI^5?cz  @J1&y,CnP@CR`Anh1  @KE(}p =@Ci"`nh2  @L+Q+ěS@G -Vn d @LzH*$Z1@Gy^5?}ca d @M V(7+@G1&xc 2 @M%% ě@GNvȴ9Xo d @M/+Gz@GEcb d @L(\-I7KƧ@HyXbMcg d @MzH.$/@HC%cd !2 @ME.1&@Hxoe1  @LM0dZ@ImVne2  @MP`A7)vȴ@FO;dn d @M̋C'@F)"`ca d @MqGz%+@E+ Ic 2 @M2nO& ě@E&Eo d @NR`A)Z1'@EScb d @N1''m@El1&ycg !2 @Nhr%V+ J@E_;dZod1 2 @OQGz)"M@E&fffffod2  @MkdZ#S@E=p n d @MO;!;dZ@EW-ca d @MS1&x@E bMc 2 @Mvȴ9X|hr@DKƧo d @LfffffM@EA7Kcb d @KlC! ě@Encg1 d @Lš_;dZ@FR\(cg2  @NFt1&y@ElCn d @NzGhr @D$/ca d @NVS@DG+ Ic 2 @N =p|hs@D333333o d @OR`A7L@Dp =cb d @OF %S@Elcg !2 @OpA7K\(@F."od1 2 @P+ I!޸Q@EnOod2  @NƧ =q@C(\n d @NwlC;dZ@C bMcaad @Nb`A@CdZcabd @M-=p =@CA7Kc !2 @MR@B/o d @N|1&N+@B=p cbad @N.vȴ9X KƧ@B$/cbbd @O+Ƨ!tj~@BGzcga!d @Mr Ĝ!o@B9XbNcgb!2 @Otjt@BEod1a2 @MSnP!tj~@Cp =od1b2 @O)^5?}#h\)@B[Sod2a2 @M@N9XbN?S@Dv-cg !2 ?@Nvȴ?Q@DQod1 2 @@Ou$/?zG@DlCod2  A@N4Z1@ j~"@Bi+ n d B@NC$@)lD@A-ca d C@M I^5@kQ@A\(c 2 D@MlC@+ I@A>zGo d E@Nf+ J@;dZ@A.vȴ9Xcb 2 F@Mj~#@S@@tog  G@MZ1@8Q@Avȴ9Xn d H@LnO;@{lC@AЃnca d I@L+lC@# =p@B97KƧc 2 J@KI^5?@xF@BQo d K@KzH@1&@AA7Kcb 2 L@L'lC@j~"@AmEog  M@L ě@w+@BEn d N@L@ =q@u\(@C@ ěca d O@LVu@!I^5?@CL1&c 2 P@MYx@!#S@CW+ Io d Q@L&$/@Q@CzGcb d R@K|hs@u\(@CVcg1 d S@K$@ t@Dz^5?|cg2 d T@KƧ@1&y@D$cd1  U@L|j~#@#hr@CD/n d V@L-@&\(\@CcEca d W@Ltj~@'lC@CRc 2 X@Kt@(F$/@CFo d Y@Mn@(`A7@B-Vcb 2 Z@Mhr Ĝo d @CZ^5?|@+l@@O;dZcb d @C!R@(`A7@@/wcg d @C/w@& =q@@lCcd1 d @B@'E@AF+ Jcd2  @B(\@.j~#@?Hr Ĝn d @B]E@.ؓtj@>tjca d @B@0fffff@=8Fc 2 @Bj=p @1-V@="`o d @AbM@.+@>{"`Bcb d @AsS@,Ձ$/@?$/cg1 d @A4E@.Gz@=5?|hcg2 d @A}/w@)&x@?9Xbcd1  @B@0gzH@<hrn d @C&+ J@1$@;ESca d @Bvȴ9@2`A7L@:RnOc 2 @Bj~#@349XbN@:So d @C33333@1 ě@:xFcb d @DX1&x@0+@;SEcg  @DVu@1-@<&xnd1 d @D`A7L@/ I^5?@;$/cd2 d @E*n@1 =q@+@0nP@9bMcb d @?b I^5@0MV@:zGcg1 d @=v+ J@/և+ J@9WO;dcg2 d @>U$/@0KC%@<Qcd1  @?9+ @/@6Aon d @>/@/Z1'@4dZca d @=Q@.# =p@4+c 2 @=C =p@+\(@4-o d @?ȴ9X@. 7KƧ@3ȴ9Xcb d @@S@/u\(@4vȴ9Xcg1 d @?1&y@. =p@2{dZcg2 d @A9XbM@-v@3`Acd1  @ȴ9X@.o@.mo d @;`A@1r Ĝ@.Scb d @:"`B@2$S@/\(cg d @:Ao@3E@.fffffcd !2 @9W =p@42 ě@01'oe1 2 @:Gz@41&x@- I^5oe2 2 @=E@.?|h@*lCoxt 2 @F5?|?"`B@31'o5' d @EI^5?x@4Mc5' d @Ea&xxF@4?;dZc4' 2 @D?|h@3no4' d @E1'lC@37 =pc3' 2 @F?-VnP@3 =po3' d @EE?|h O;d@2Y+ c2' d @D"`B"`@2Ovc1'  @D-V+ I@1tjn1 d @D|(\QR@/\(c2 !2 @D'+Ƨ-@/hro2  @D"`hr!@-hr n3 d @D1'r ě@-{lCc4 !2 @D+ I?ݑhr @+\1&o4 d @EC?vȴ@/-c5 d @E`A7?Q@/;dZc5m d @E1Gz@1Sc6 ! @D/vȴ9@%1&x@Ex1&xs ""2 @DlC@$ A7K@Ez^5?|o1 2 @CnO@%F@D° ěo2 2 @CXbM@$1&@EQo3 2 @DJ~"@(F$/@ESo4  @@vȴ9nO;@:1&ys ""2 @AMnO@:qhr o1 2 @@`A7 I^5@9tjo2 2 @@SP`A7@;|hso3 2 @A&+ JZ1'@;-Vo4 2 @CMV@*|j~#@"7Kƨo 2 @Eov N+@DV+ Jo 2 @?33333@(M?ȴ9Xbo 2 @7\(?ffffff@F ěo 2 @MR?-V@HQGzo 2 @Dn@ QR@Di^5?}o 2 @=fffff@xF(\o 2 @:&fffff /v@HI^5?o 2 @6(\' ^5?}@@Ձ$/o 2 @Ar Ĝ-bM@'Eo 2 @Fg-@#`A7L@!Vuo 2 @-\(\S@:$/o 2 @Dr I^5vȴ9X@"}Eo 2 @CzG@!S@>mVo 2 @@\)@+E@ vȴo 2 @=2nO@+@E+ Jo 2 @FCS$7+!k I^@%`A7o 2 @IM@ bM@' I^5o 2 @Ir Ĝ@&-V@@So 2 @B߾vȴ9@'ěT1&xo 2 @Hn t@(9XbNo 2 @JjG{lC@&_vȴ9o 2 @@.5?|@vȴ `A7Ko 2 @Dx@1˅Q@.PbMo 2 @vȴ9X??|hso 2 $@Fi^5?}@*E@Ci^5?}o 2 %@M``A7.~"@F6ȴ9Xo 2 &@Lvȴ9X@0H\)@BDEo 2 '@NnO$Rm@CVo 2 (@CVu"2-V@J vȴo 2 )@A֧-@8Q@<޸Qo 2 *@F j~#@(7+@@ݑhr!o 2 +@<=p =p?GzHo 2 ,@A$E@#\)@!|j~#o 2 -@F~"ѿlC@GzHo 2 .@?e`A7LI^5?QRo 2 /@;;dZ@.@Cu`A7Lo 2 0@C!7Kƨ+ I@1bMo 2 1@@SěS@6y+ o 2 2@G(\@3ov@EnVuo 2 3@)-V,1&y@?|hro 2 4@E@#@@O;o 2 5@BA&x@1/v@@1&xo 2 6@8@;dZ@$/o 2 7@;N+@'5?|@"o 2 8@CX9Xbvȴ9X&*~"o 2 9@1Mhr!lD@CnOo 2 :@@+ 'vȴ9X?nO;o 2 ;@?TzG@*0 =q@Coo 2 <@36E@0%So 2 =@F,1&y@ nO@ȴ9Xbo 2 >@B\(@hr!@Fu$/o 2 ?@EZ1@%j~@CL(\o 2 @@@" I^5@$E1&xo 2 A@Cov?Q%WO;do 2 B@FGz@.tj@E\(o 2 C@FlC$|j~#@1&xo 2 D@@>Vu@0k I^@(Yo 2 E@FuQ. =p@FQo 2 F@E;dZ!'-@+)xo 2 G@I0ěT@ \(@> I^o 2 H@6S\(@8 I^5o 2 I@I9XbN@=p @<zGo 2 J@CE`A7L@1-V@-o 2 K@C>Q@%bMno 2 L@G6$/@2@3/wo 2 M@MlC@vȴ@F#nPo 2 N @=0 =q@++ @D\(\o 2 O @C߾vȴ9;dZ@ A7Kƨo 2 P @EA7K@ &x(O;do 2 Q @E^O;@nP@5^5?|o 2 R @I!&x&Z1'zG{o 2 S@L;Q@2R@B?vȴ9o 2 T@E:1'@$V@B/o 2 U@0+ J#Vu@2_|hso 2 V@;/@tj?o 2 W@3㕁$@)ۥS@D$/o 2 X@Iڟvȴ)R@Doo 2 Y@H?;dZ#r Ĝ@ @no 2 Z@88bM ěT@6tzGo 2 [@JS(׍O;d@@fffffo 2 \@Fp =q+O; vȴ9Xo 2 ]@JXbM@07KƧ@A"`Bo 2 ^@9_vȴ9@0c$@CO;dZo 2 _@Affffff+$/@8`A7o 2 `@F =p!M@G2`Ao 2 a@D^5?}@(\(@Dno 2 b@LH9Xb@3t@CbMo 2 c@Gr I^5@ p =q@= =po 2 d@N@#m@E+ Jo 2 e @D33333@% C%\(o 2 f!@B@,1'@'Yo 2 g"@5hr!;dZ@Ghr!o 2 h#@5/w@25?|h@:7KƧo 2 i$@4?vȴ9$E@@xo 2 j%@:WKƧ@-Zvȴ@@7+ Io 2 k&@@qR@3^5?|@8\)o 2 l'@EY^5?}00`A7@Evo 2 m(@Dvȴ.$/@G$/o 2 n)@; ě I^5@3+ Io 2 o*@NěTR@A1&xo 2 p+@EIXbM0L1&y@Cxo 2 q,@,7KƧ?dZ1@; o 2 r-@DA7K@0!o@BFo 2 s.@HI^5?@S@I/;dZo 2 t/@Aȴ9Xb"8FEo 2 u0@4S@49XbN@0Q&xo 2 v1@HQ@$+mhr!o 2 w2@># =p9XbN@<@A7Ko 2 x3@F G{$/@8Hr Ĝo 2 y4@.\(@zG@8Fo 2 z5@=1'-V+ J@Hno 2 {6@E\)@"`A@GV$/o 2 |7@1^5?| =p @Dvȴ9o 2 }8@1 =pƧ-@+tjo 2 ~9@@@o3x@C\(o 2 ?@+cS@ Y@@=p o 2 @@C =p I^@:9Xbo 2 A@I|hs@+TE@Iև+ Jo 2 B@@-p =$tj@tj~o 2 C@H=-V@'\(@2 1&yo 2 D@GF@+`Ao 2 E@C-V)@!G{o 2 F@2-V3qhr @5p`A7o 2 G@DC%,7Kƨ@9ěSo 2 H@<zG@2Ao@3/vo 2 I@KR-V@Ƨ-@KO;o 2 J@J!R@ 7KƧ@+sEo 2 K@Eu?|h ěT@@o 2 L@NO\(@'$/@Dbmo 2 M@6+ J@/L@Chtjo 2 N@G-V,-Vffffffo 2 O@<'-@'Z1'@Evo 2 P@07KƧ@l@1tjo 2 Q@5]/w@."`A@DFo 2 R@D`A7j~#@8o 2 S@H?|hs@0Vu@0ɺ^5?}o 2 T@?Ov@/@?j~o 2 U@Fhr!@$ ě@GQhr o 2 V@D"`B@S@G$Eo 2 W@C>Q4vȴ9X@6o 2 X@ClCvȴ9X@3Qo 2 Y@InO@6 =p@Bhr Ĝo 2 Z@N=hr!!`A7@Fj~#o 2 [@NSS@ @Bqoo 2 \@)# =p@#O;dZ@A&xo 2 ]@FY"`@#ٙ(ؓtjo 2 ^@<-@*m@333333o 2 _@M7Kƨ@ C%@AvEo 2 `@CA7K@*ql!Ro 2 a@G9XbN)$/?bMo 2 b@D#nPQR@F6fffffo 2 c@EI@'LI^5?@9XbNo 2 d@?L1&y@bMnOo 2 e@Ltj~@!333333@K\)o 2 f@=]-VnP?ٺ^5?|o 2 g@:I^5?2C@84Eo 2 h@A S);dZ@/9Xbo 2 i@-(\ =p@@Z1o 2 j@AzG5?|@;O;dZo 2 k@M9Xb@4XbM@C\(o 2 l@B 1& =p @Hr Ĝo 2 m@B)"`B@7㕁$o 2 n@FglC@$/+=p =o 2 o@BAGzO;@IBmo 2 p@H$/-)x@Co 2 q@FRnO0e@E ^5?}o 2 r@3S@QR@3y"`o 2 s@KC%-V@Jxo 2 t@0zG@ix@CQlo 2 u@E7Kƨ@o-V'p =qo 2 v@CSo+H1&xo 2 w@?33333\)|hro 2 x@3@'Q@E;dZo 2 y@AXbM%x@1A7Ko 2 z@OF@ E@B "`o 2 {@6%S@1vȴ9X@BC33333o 2 |@IXFvȴ@, =po 2 }@77Kƨ6O;d@A =po 2 ~@N =q@01&y@Bzvȴo 2 @IbM Gz@,G{o 2 @8M:^5?|@' =po 2 @Eo(E?QRo 2 @?Z1tj@QRo 2 @D3E@+dZ@BO;dZo 2 @=3tj~6O;dZ@C9Xbo 2 @M/w9XbM@Hoo 2 @DR =p @So 2 @7SE3F@Ato 2 @0S@' I^@8"`o 2 @8,I^5?5ۥS@9fffffo 2 @;0bM?Vt?&xo 2 @.)(r Ĝ@A/;dZo 2 @05$/2n@<`A7o 2 @)^5?}E@4hr o 2 @:t@$/So 2 @HMp =@3ěT@A+ Jo 2@GXbM?GzH@5-Vo 2@EO;d?E@4/o 2@@vȴ/v@:>Qo 2@B1&x@,;dZ@BGzo 2@o 2@/A$/@1vE@>ȴ9Xo 2@5?|@>vȴ9Xo 2!@I?|h@)5?|@=$/o 2"@-["`B@F-@@Qo 2#@CTtj@)}p =Z1'o 2$@C$/@0M@AԼj~o 2%@@ ě2j~@;G+ Io 2&@Cv$//PbM@@"`o 2'@Gѩl(tj@'F-o 2(@Ao3S@Avȴ9Xo 2)@0XbM@~"@DO;dZo 2*@5y(glC@--Vo 2+@CR?+@Fvo 2,@F A7K@-1&xo 2-@=.(r Ĝ@#$/o 2.@Jtj@+ @90 ěo 2/@@1&y. @F@ ěo 20@H ě&+ J@Vo 21@HE?S@0i7KƧo 22@;-"`A"ٙo 23@@33333@'E@E|I^5?o 24@C`A7L1:G{@AO;dZo 25@'Ձ$/A7Kƨ@4@G,I^5?@1 Ƨo 2?@N+ @333333@IRmo 2@@9ix ěT@4l1&yo 2A@,3EE@2so 2B@A I^"`A@86+ Jo 2C@B8r Ĝ ě@@"nOo 2D@%tj~#1&x@5+ Jo 2E@L&x$/@=vȴ9o 2F@59Xb$# =p@%to 2G@B\@ I^5?@?tEo 2H@8䛥S@2(\@1 I^o 2I@Lo9XbN@c =p@1O;dZ@A"o 2T@Bm%&x`A7o 2U@M6t* ě@DVEo 2V@'x@+ @9Vuo 2W@FA7K?ěS@; no 2X@NO;@ I^5@Jp =o 2Y@>zG{ + I^@I33333o 2Z@:DS@" ě@F$j~o 2[@FffffflC@=z^5?|o 2\@2+0n@AO;dZo 2]@H1&鿛S,tj~o 2^@LQGz%#S@Dmo 2_@I&fffff@, I^5@:~"o 2`@NG{? =p@F333333o 2a@El1&y'v'1&yo 2b@@O;bM!`A7Ko 2c@Gtj@/0 =q@:Ұ ěo 2d@@\(@glCGzo 2e @/bMVu@Armo 2f!@ClI^5?)I^5?@Ixo 2g"@Fm@0@>(9Xbo 2h#@HxbM@,B I^5@IVuo 2i$@@Lj~#2zG@@ěTo 2j%@NƧ@/0 ě@C&xo 2k&@ES@n@=-Vo 2l'@N =q. @H97KƧo 2m(@O@2@DI"`o 2n)@DSϿj~"@?lCo 2o*@<$/@.Q@?Eo 2p+@KzG{@1H1&x@HSo 2q,@;"\(@+zG{@'_vȴ9o 2r-@5ȴ9X2wO;d@Bq$/o 2s.@L"`B@41'@H:vȴo 2t/@GޗO;@$u?|h@/$/o 2u0@GF@6A$/@EMhr!o 2v1@DQ)sE) I^5?o 2w2@Jhr *E@B bMo 2x3@8t@ /v@Gɺ^5?}o 2y4@CE@4I^5?@A7Kƨo 2z5@0bM\(@CD9XbNo 2{6@OKƧ-V@E33333o 2|7@F|hs@*o@hr o 2}8@=9XbN?333333@I33333o 2~9@Bv+ J@š@G-Vo 2:@NFȴ9X@xF@D =po 2;@G+ I@lD@9Ixo 2<@N)lD@ hr!@F|hso 2=@H1l@#'lC@$p =qo 2>@,Vu@&cS@8Lo 2?@&1&xnO@<=-Vo 2@@<|hs1 1&y@+5?|ho 2A@1\)@#A$/@4D/o 2B@? @lCtjo 2C@ B9zB6zB6 =BA\BEQBEpBFBHBLBVpBX BVzBCffBCB@{B@BD{BHBF{BT=qB=qB\)B+zA =A(BGB#B 33B B zA =A\)B33BB2B zB1(BGB ffBRBF{BBB\B B"GB RAB 33BQB7B =BB%(AB%B =qAB =AиRB$B HB. =BEA ApB\B)BB%BBB9RAGA\)B!BpB/{BpB=qB(zB)\BzB"B BB9AA\BBBRB{A޸RBBBB5RB9 BBRBB1{BB =B =B'\B#B {AHB,=qB HB(BffB%ffB9{B#(B(BQBQBBzBpB\)BE33B+Bw =BFB zBX{B/HBzBBAQBBB0 =B, B#zB\)BVB2B9 =BzB0zB BQBH\B5B=qAB6\)B0=qBKpB0ffB*GB- B*B{B6ffBMB1 B GB;HB8B' =B'33B*B6 B5B0B133B*pB%GBEB?BBB(BN{B#(B!HBB*\)BGBj\)B$ =B,B= BBGBC=qB%B:B. =BYB pB:\B@B( F1F2F3F4F5F6F7                                                          f f f f               f f f                 f          B     f f f f f f f f f f f f f f      f f f f f f              f f f     f f f f f f f f f        f f f f f f f f f            B      f f f f f f              f f f f f                 f f f         f f f f f f f                     f f        f f f f f f f         B        f f f                    f f f f                              f f f           f f f f       f f f f     ,              f f f f f f f f f f f f f f f     f f f f f f    f f f        f f f f   B             f f f f f f f f      f f #binding site for residue thm a 434ac10F#binding site for residue thm a 434ac1F#binding site for residue so4 a 435 ac2F #binding site for residue so4 a 436_oac3Fq{=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine ..MOD_RESp=met->mse selenomethionine 55MOD_RESp=met->mse selenomethionine ??MOD_RESp=met->mse selenomethionine AAMOD_RESp=met->mse selenomethionine GGMOD_RESp=met->mse selenomethionine ppMOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine MOD_RESp=met->mse selenomethionine jjMOD_RESp=met->mse selenomethionine kkMOD_RESpKG@@?AA@@?AAA @@@?AA@@?AAA APA@@?AAA0@@?AAA @@@?AAA0@@?AAA0@@?AAA AP@@@?AAA APA@@?AAA APA@@?AAA APA@@?AAA @@@?A@@?AAA @@A@A`@@@?AA@@?AAA A0A@@@?AA@@?AA@@?AAA AP@@@?AAA AP@@@?AAA0@@?AAA @@@?AAA A0A@A`ApA@@?AAA A0A@A`ApA@@?AAA0@@?A@@?A@@?AAA A0A@A`ApA@@?AA@@?AAA APA@@?A@@?AAA @@@?AAA0@@?AAA AP@@?AAA @@@?AAA A0A@A`ApA@@?AAA AP@@@@?AA@@?AA@@?AA@@?AAA A0A@@@?AA@@?AA@@?AAA0@@?AAA A0A@A`ApA@@?AAA A0A@A`ApA@@?AAA AP@@@@?AAA @@@?AAA @@@?AAA @@@?AAA @@@?AAA AP@@@?AAA APA@@?AA@@?AA@@?AAA A0A@@@?AA@@?AA@@?AA@@?AAA @@@?AA@@?A@@?AAA @@@?AAA0@@?AAA @@@?AAA A0A@@@?AA@@?AAA @@@?AAA0@@?AAA APA@@?A@@?AA@@?AAA APA@@?AA@@?AAA @@@?AAA APA@@?AAA @@A@A`@@@?AA@@?AA@@?A@@?A@@?AA@@?A@@?AAA @@@?AA@@?AA@@?AA@@?AAA A0A@@@?AA@@?AAA A0A@@@?AA@@?AAA AP@@?AAA A0A@@@?AA@@?AA@@?AA@@?AA@@?AAA @@@?AA@@?AAA AP@@?AA@@?AA@@?AAA APA@@?AA@@?A@@?AAA APA@@?A@@?AAA A0A@@@?A@@?AAA @@A@A`@@@?AA@@?A@@?A@@?AA@@?AAA0@@?AAA @@@?AAA APA@@?AAA A0A@@@?AAA AP@@@?AA@@?AAA0@@?AAA @@@?A@@?AAA A0A@A`ApA@@?AAA @@A@A`@@@?AA@@?AAA AP@@@?AAA0@@?AAA @@@?AAA AP@@@?AA@@?AA@@?AAA A0A@A`ApA@@?AA@@?AAA APA@@?AAA A0A@@@?AA@@?AAA @@@?AAA AP@@@@?AAAA A @@@@?AAA APA@@?AA@@?AA@@?AA@@?AA@@?A@@?AAA AP@@@@?AA@@?A@@?AAA @@@?AAA A0A@@@?AA@@?AAA AP@@?AA@@?AAA @@@?AAA APA@@?AAA APA@@?AAA A0A@@@?AAA A0A@A`ApA@@?AA@@?AAA A0A@@@?AAA APA@@?AAA @@@?AA@@?AA@@?A@@?AA@@?AA@@?AAA @@@?AA@@?AAA0@@?AAA AP@@?AAA A0A@@@?AAA0@@?AA@@?AA@@?AA@@?AAA0@@?AA@@?AAA APA@@?AAA APA@@?AAA0@@?AA@@?AA@@?A@@?AA@@?AAA @@@?AA@@?AAA0@@?AA@@?AAA A0A@@@?AAA @@@?AA@@?AAA APA@@?AA@@?A@@?AA@@?A@@?AA@@?AAA A0A@A`ApA@@?AAA APA@@?AA@@?AAA A0A@@@?AAA AP@@@?AAA @@@?AA@@?AAA AP@@@?AA@@?AAA A0A@@@?AA@@?AAA @@A@A`@@@?AA@@?AA@@?AAA APA@@?AAA0@@?A@@?AAA @@@?AAA @@@?AA@@?A@@?AAA APA@@?AAA @@@?AA@@?AA@@?AAA0@@?AAA0@@?AA@@?AAA @@@?AAA @@@?AAA AP@@@@?AAA AP@@?AAA A0A@@@?A@@?AAA APA@@?AA@@?AAA0@@?A@@?AAA @@@?AA@@?AAA A0A@@@?AAA AP@@@?AAA A0A@@@@?AAAA A APAP@@@@@@?AAA AP@@@?AA@@?AAA0@@?AAA @@@?AA@@?AAA A0A@@@?AAA APA@@?A@@?AAA AP@@@@?A@@?AAA AP@@?AAA APA@@?AAA @@@?AAA A0A@@@?AA@@?AAA AP@@@?AAA A0A@@@?AA@@?AAA A0A@@@?AA@@?AAA A0A@@@?A@@?AA@@?AAA AP@@@@?AA@@?AA@@?AAA A0A@@@?AA@@?AAA @@@?AAA APA@@?AA@@?AAA AP@@@?AA@@?AAA A0A@@@?AAA AP@@@?AAA AP@@@?AA@@?AAA APA@@?AA@@?AAA A0A@@@?AAA A0A@@@?AAA0@@?AAA AP@@@?AA@@?AAA0@@?AAA @@@?AA@@?A@@?AA@@?AA@@?AAA A0A@@@?AAA AP@@@?AAA APA@@?AAA A0A@A`ApA@@?AAA APA@@?AA@@?AAA A0A@A`ApA@@?AAA0@@?AAA APA@@?AAA @@@?AAA AP@@@@?A@@?A@@?AAA @@@?AAA AP@@@?AA@@?AA@@?AAA0@@?AAA @@@?AAA @@A@A`@@@?AAA AP@@?AAA AP@@@?AAA APA@@?AAA A0A@@@?AAA AP@@?AAA AP@@@@?AA@@?AAA AP@@@@?AAA A0A@A`ApA@@?AAA AP@@@@?AAA0@@?AAA AP@@@?AAA A0A@A`ApA@@?AAA APA@@?AA@@?AAA APA@@?AAA APA@@?AA@@?A@@?AAA A0A@A`ApA@@?AA@@?AA@@@?AAAA A APAP@@@@?AAA A0A@@@?AA@@?AA@@?AAA @@@?AAA @@@?AAA0@@?A@@?AA@@?AA@@?AA@@?AAA A0A@@@?A@@?AA@@?A@@?AAA APA@@?AAA A0A@@@?AA@@?AAA APA@@?AAA AP@@@?AAA @@@?AAA @@@?AAA0@@?AAA @@@?AAA A0A@@@?AA@@?AA@@?A@@?AAA0@@?AA@@?AAA A0A@@@?AAA @@@?AAA APA@@?AAA APA@@?AAA0@@?A@@?AAA @@@?AAA APA@@?AA@@@?AAAA A APAP@@@@?AAA AP@@@?A@@?AAA AP@@@?AA@@?AAA A0A@@@?AAA A0A@@@?AA@@?AAA0@@?AAA @@A@A`@@@?AA@@?AAA @@@?AAA APA@@?AAA AP@@@@?AAA @@@?AA@@?AAA @@@@?AAAA A @@@@?AA@@?AA@@?AAA APA@@?AAA APA@@?AAA A0A@@@?AAA @@@?AA@@?AA@@?AAA0@@?AA@@?AAA0@@?AA@@?AAA @@@?AAA @@A@A`@@@?AA@@?AA@@?AA@@?AAA AP@@?AA@@?AAA A0A@@@?AAA0@@?AAA @@A@A`@@@?AAA APA@@?AAA0@@?AAA0@@?AA@@?AAA AP@TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\TTTT\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\TT\\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\\\\TTT\TTTT\TT\\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\\TT\\\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT\TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT3H5Q 4 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 a a a a a 5 5 5 5 5 5 5 5 5 5 5 5 5 b b b b 6 6 6 6 6 6 6 7 7 7 7 7 7 7 7 7 7 7 7 7 b b b b 8 8 8 8 8 8 8 8 8 8 8 8 8 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 a a a a a a a a 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 a a a a a a a c c c 11 11 11 11 11 11 11 11 11 11 11 11 11 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 14 14 14 14 14 14 14 14 14 14 14 14 14 14 15 15 15 15 15 15 16 16 16 16 c c c c c c d d d d d d 17 17 17 17 17 17 17 17 17 17 17 17 c c c c d d c c c c c c c 18 18 18 18 18 18 18 18 18 18 18 d d d d a a a a a0K;M?Qjpyrimidine-nucleoside phosphorylase; chain: a; synonym: pynp; ec: 2.4.2.2; engineered: yes; mutation: yes3H5QB13h5qP 1 2 1BN]/B#=B'???a???@Y˥S? 4AHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWAHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW4"aa                  ffffffffBffffffffffffff fffffffff ffffffffffffffffffB ffffffffffffff fffffffff fffffff Bffffffffffffff ffff , fffffffffffffff ffffff fff ffffB ffffffff ffaathmWappend] Xthm thymidineaaso4sadd molcaaso42sawaawa2awa3awa4awa5awa6awa7awa8awa9awa10awa11awa12awa13awa14awa15awa16awa17awa18awa19awa20awa21awa22awa23awa24awa25awa26awa27awa28awa29awa30awa31awa32awa33awa34awa35awa36awa37awa38awa39awa40awa41awa42awa43awa44awa45awa46awa47awa48awa49awa50awa51awa52awa53awa54awa55awa56awa57awa58awa59awa60awa61awa62awa63awa64awa65awa66awa67awa68awa69awa70awa71awa72awa73awa74awa75awa76awa77awa78awa79awa80awa81awa82awa83awa84awa85awa86awa87awa88awa89awa90awa91awa92awa93awa94awa95awa96awa97awa98awa99awa100awa101awa102awa103awa104awa105awa106awa107awa108awa109awa110awa111awa112awa113awa114awa115awa116awa117awa118awa119awa120awa121awa122awa123awa124awa125awa126awa127awa128awa129awa130awa131awa132awa133awa134awa135awa136awa137awa138awa139awa140awa141awa142awa143awa144awa145awa146awa147awa148awa149awa150awa151awa152awa153awa154awa155awa156awa157awa158awa159awa160awa161awa162awa163awa164awa165awa166awa167awa168awa169awa170awa171awa172awa173awa174awa175awa176awa177awa178awa179awa180awa181awa182awa183awa184awa185awa186awa187awa188awa189awa190awa191awa192awa193awa194awa195awa196awa197awa198awa199awa200awa201awa202awa203awa204awa205awa206awa207awa208awa209awa210awa211awa212awa213awa214awa215awa216awa217awa218awa219awa220awa221awa222awa223awa224awa225awa226awa227awa228awa229awa230awa231awa232awa233awa234awa235awa236awa237awa238awa239awa240awa241awa242awa243awa244awa245awa246awa247awa248awa249awa250awa251awa252awa253awa254awa255awa256awa257awa258awa259awa260awa261awa262awa263awa264awa265awa266awa267awa268awa269awa270awa271awa272awa273awa274awa275awa276awa277awa278awa279awa280awa281awa282awa283awa284awa285awa286awa287awa288awa289awa290awa291awa292awa293awa294awa295awa296awa297awa298awa299awa300awa301awa302awa303awa304awa305awa306awa307awa308awa309awa310awa311awa312awa313awa314awa315awa316awa317awa318awa319awa320awa321awa322awa323awa324awa325awa326awa327awa328awa329awa330awa331awa332awa333awa334awa335awa336awa337awa338awa339awa340awa341awa342awa343awa344awa345awa346awa347awa348awa349awa350awa351awa352awa353awa354awa355awa356awa357awa358awa359awa360awa361awa362awa363awa364awa365awa366awa367awa368awa369awa370awa371awa372awa373awa374awa375awa376awa377awa378awa379awa380awa381awa382awa383awa384awa385awa386awa387awa388awa389awa390awa391awa392awa393awa394awa395awa396awa397awa398awa399awa400awa401awa402awa403awa404awa405awa406aa1                  ffffffffBffffffffffffff fffffffff ffffffffffffffffffB ffffffffffffff fffffffff fffffff Bffffffffffffff ffff , fffffffffffffff ffffff fff ffffB ffffffff ffaathm1W ؀D ~DXthm thymidineaaso43s ;D X9Daaso421s C PCawa407awa2100awa3100awa410awa510awa610awa710awa810awa910awa1010awa1110awa1210awa1310awa1410awa1510awa1610awa1710awa1810awa1910awa2010awa2110awa2210awa2310awa2410awa2510awa2610awa2710awa2810awa2910awa3010awa3110awa3210awa3310awa3410awa3510awa3610awa3710awa3810awa3910awa408awa411awa421awa431awa441awa451awa461awa471awa481awa491awa501awa511awa521awa531awa541awa551awa561awa571awa581awa591awa601awa611awa621awa631awa641awa651awa661awa671awa681awa691awa701awa711awa721awa731awa741awa751awa761awa771awa781awa791awa801awa811awa821awa831awa841awa851awa861awa871awa881awa891awa901awa911awa921awa931awa941awa951awa961awa971awa981awa991awa1001awa1011awa1021awa1031awa1041awa1051awa1061awa1071awa1081awa1091awa1101awa1111awa1121awa1131awa1141awa1151awa1161awa1171awa1181awa1191awa1201awa1211awa1221awa1231awa1241awa1251awa1261awa1271awa1281awa1291awa1301awa1311awa1321awa1331awa1341awa1351awa1361awa1371awa1381awa1391awa1401awa1411awa1421awa1431awa1441awa1451awa1461awa1471awa1481awa1491awa1501awa1511awa1521awa1531awa1541awa1551awa1561awa1571awa1581awa1591awa1601awa1611awa1621awa1631awa1641awa1651awa1661awa1671awa1681awa1691awa1701awa1711awa1721awa1731awa1741awa1751awa1761awa1771awa1781awa1791awa1801awa1811awa1821awa1831awa1841awa1851awa1861awa1871awa1881awa1891awa1901awa1911awa1921awa1931awa1941awa1951awa1961awa1971awa1981awa1991awa2001awa2011awa2021awa2031awa2041awa2051awa2061awa2071awa2081awa2091awa2101awa2111awa2121awa2131awa2141awa2151awa2161awa2171awa2181awa2191awa2201awa2211awa2221awa2231awa2241awa2251awa2261awa2271awa2281awa2291awa2301awa2311awa2321awa2331awa2341awa2351awa2361awa2371awa2381awa2391awa2401awa2411awa2421awa2431awa2441awa2451awa2461awa2471awa2481awa2491awa2501awa2511awa2521awa2531awa2541awa2551awa2561awa2571awa2581awa2591awa2601awa2611awa2621awa2631awa2641awa2651awa2661awa2671awa2681awa2691awa2701awa2711awa2721awa2731awa2741awa2751awa2761awa2771awa2781awa2791awa2801awa2811awa2821awa2831awa2841awa2851awa2861awa2871awa2881awa2891awa2901awa2911awa2921awa2931awa2941awa2951awa2961awa2971awa2981awa2991awa3001awa3011awa3021awa3031awa3041awa3051awa3061awa3071awa3081awa3091awa3101awa3111awa3121awa3131awa3141awa3151awa3161awa3171awa3181awa3191awa3201awa3211awa3221awa3231awa3241awa3251awa3261awa3271awa3281awa3291awa3301awa3311awa3321awa3331awa3341awa3351awa3361awa3371awa3381awa3391awa3401awa3411awa3421awa3431awa3441awa3451awa3461awa3471awa3481awa3491awa3501awa3511awa3521awa3531awa3541awa3551awa3561awa3571awa3581awa3591awa3601awa3611awa3621awa3631awa3641awa3651awa3661awa3671awa3681awa3691awa3701awa3711awa3721awa3731awa3741awa3751awa3761awa3771awa3781awa3791awa3801awa3811awa3821awa3831awa3841awa3851awa3861awa3871awa3881awa3891awa3901awa3911awa3921awa3931awa3941awa3951awa3961awa3971awa3981awa3991awa4001awa4011awa4021awa4031awa4041awa4051awa4061 _ser  Hasn    Hala  Hmse Harg & ! "!#"$%##' Hmse'&(*.')('+*,+-,/ Hile(/.026/10/3425237 Hasp0768:>7987;:<=;;? Hile8?>@BF?A@?CDBEBCG Hile@GFHJNGIHGKLJMJKO Hglu HONPRWOQPOSRTSUVTTX  Hlys PXWY[`XZYX\[]\^]_^a  Hlys Ya`bdiacbaedfegfhgj  Harg bjikmtjlkjnmonpoqprsqqu  _aspkutvx|uwvuyxz{yy}  _glyv}|~}~ _his ~ _thr _leu _thr Hthr Hglu  Hglu  Hile Hasn Hphe  Hphe  Hile Hgly Hgly Htyr  Hval Hlys       _gly       _asp ! _ile " _pro %!#& "! $#%$'# Hasp!'&(*.')('+*,-++/$ Htyr (/.02:/10/3245363748586798;% Hgln 0;:<>C;=<;?>@?AB@@D& Hala <DCEGHDFEDI' Hser EIHJLNIKJIMLO( Hser JONPRTOQPOSRU) HleuPUTVX\UWVUYXZ[YY]* Hala V]\^`a]_^]b+ Hmse^baceibdcbfegfhgj, Hala cjikmnjlkjo- Hilekonprvoqpostrursw. Htyr pwvxzwyxw{z|}{~{|}~/ Hphe x0 Hgln 1 _asp2 _mse3 _asn4 Hasp5 Hasp6 Hglu 7 Harg 8 Hval9 Hala : Hleu; Hthr< Hmse = Hala > Hmse? Hval        @ Gasn A Gser B _gly !C _asp! "$(!#"!%$&'%%)D _mse")(*,0)+*)-,.-/.1E _ile*1024813215647459F _asp298:<@9;:9=<>?==AG _leu:A@BDHACBAEDFGEEIH _ser BIHJLNIKJIMLOI _aspJONPRVOQPOSRTUSSWJ _ilePWVXZ^WYXW[\Z]Z[_K _lys X_^`bg_a`_cbdcedfehL _gly`hgikhjilM _valilkmorlnmlpqoosN _lys msrtv{sutswvxwyxzy|O Evalt|{}|~}|P Easp}Q Elys R Ehis S Eser T _thrU _glyV _glyW _valX _glyY _aspZ _thr[ Hthr\ Hthr] Hleu^ Hval_ Hleu` Hala a Hprob Hleuc Hval       d Hala     e Hala f Gvalg _asp!% "!#$""&h _val&%'),&('&*+))-i _pro'-2,.03-/.-102,14j Eval.4357:46548977;k Eala 5;:<>?;=<;@l Elys <@?ACH@BA@DCEDFEGFIm EmseAIHJLPIKJIMLNMONQn _ser JQPRTVQSRQUTWo _glyRWVXZWYX[p _arg X[Z\^e[]\[_^`_a`bacdbbfq _gly\fegifhgjr _leugjikmqjlkjnmopnnrs _glykrqsurtsvt _his svuwyvxwvzy{|z}z~{~|}u _thrwv _glyw _glyx Hthry Hilez Hasp{ Hlys | Hleu} Gglu ~ Gala  _ile _asp _gly _phe  _his  _val _glu  _ile _asp         Hglu   Hala  Hthr" !# Hphe #"$&-#%$#'&()'*'+(,),*+. Hval$.-/14.0/.23115 Hlys /5468=576598:9;:<;> Hleu6>=?AE>@?>BACDBBF Hval?FEGILFHGFJKIIM HasnGMLNPTMONMQPRSQQU _glu NUTVX]UWVUYXZY[\ZZ_ _asn V^_]`b]`cj^_a`^d_ebfhcgidedek _lys `kjlnskmlkonpoqprqt Evalltsuwztvutxyww{ Eala u{z|~{}|{ Eval| Eval _gly _gln  _ser  _gly _asn _leu _thr Hpro Hala  Hasp Hlys  Hlys  Hleu Htyr  Hala  Hleu Harg          Gasp  Gval _thr #!"  $ _gly$#%'$&%( _thr%(')+.(*)(,-++/ _val)/.025/10/34226 _asn06579=6876:9;<::> _ser 7>=?AC>@?>BAD Hile?DCEGKDFEDHIGJGHL HproELQKMORLNMLPOQKPS HleuMSRTVZSUTSWVXYWW[ HileT[Z\^b[]\[_`^a^_c Hala \cbdfgcedch Hser dhgikmhjihlkn Hser inmoqsnponrqt Hileotsuw{tvutxywzwx| Hmseu|{}|~}| Hser } Hlys  Hlys  Hile Hala  _ala  _gly _ala  _asp Eala  Eile Eval