73.6-1h /data/swissprot/ 3PGY.pdbdupa 1KKJ.pdb![html] [head] [style type="text/css"] body { background-color: #FFFDF3; } a { text-decoration: none; } #tabs { border-bottom: .5em solid #801010; margin: 0; padding: 0; } #page1 #tabs li#tab1 a, #page2 #tabs li#tab2 a, #page3 #tabs li#tab3 a, .page4 li#tab4 a { padding: 0.25em 1em; border: solid; border-width: 1px; border-color: #801010; border-bottom: none; #background-color: none; color: #000; } #main { border-top :1px solid #666; clear: both; background: #FFFDF3; padding-top: 1px; padding-left:1px; padding-right:1px; padding-bottom:1px; min-width: 384px; } #contents { padding-top: 1px; padding-left:2px; padding-right:2px; padding-bottom:1px; background: #FFFDF3; min-width: 380px; } #header { position: relative; width: 100%; height: 3em; min-width: 384px; } #header ul#primary { margin: 0; padding: 0px; position: absolute; bottom: -1px; width:100%; } #header ul#primary li { display: inline; list-style: none; width:100%; } #header ul#primary a,#header ul#primary span,#header ul#primary a.current { display: block; float: left; padding:4px; margin: 1px 2px 2px 2px; text-align: center; font-family: tahoma, verdana, sans-serif; font-size: 85%; text-decoration: none; color: #333; } #header ul#primary span,#header ul#primary a.current,#header ul#primary a.current:hover { border: 1px solid #666; border-bottom: none; background: #FFF3B3; padding-bottom: 6px; margin-top: 0; } #header ul#primary a { background: #FFFAE1; border: 1px solid #AAA; border-bottom: none; } #header ul#primary a:hover { margin-top: 0; border-color: #666; background: #FFF7CD; padding-bottom: 5px; } #header ul#secondary { position: absolute; margin: 0; padding: 0; bottom: -1.4em; left: 1px; width: 50em; /* a width is required for Opera, older Mozilla browsers, and Konqueror browsers */ } #header ul#secondary li a,#header ul#secondary li span { width: auto; display: block; float: left; padding: 0 10px; margin: 0; border: none; border-right: 1px dotted #AAA; background: none; } #header ul#secondary li a { color: #06C; text-decoration: underline; } #header ul#secondary li a:hover { color: #333; background: transparent; padding: 0 10px; border: none; border-right: 1px dotted #AAA; } #header ul#secondary li a:active { color: #000; background: transparent; } #header ul#secondary li:last-child a { border: none; } [/style] [title]Annotation[/title] [/head] [body] [img src="#icm/image/album/csgid.png"] [hr] [h3]Serine Hydroxymethyltransferase From Staphylococcus Aureus, S95P Mutant.[/h3] [p]J.Osipiuk, M.Makowska-Grzyska, K.Kwon, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases (Csgid)[/p] [h3]PDB Code: [a href="http://www.rcsb.org/pdb/explore.do?structureId=3PGY" target="blank"]3PGY[/a] [small](deposited on 02-NOV-10)[/small][/h3] [h3]Structural data[/h3] [p][!--icmscript name="1" display slide=slideshow.slides index="Asymmetric unit" --] [a name="1" href="#_"]Asymmetric unit[/a] [/p] [p][!--icmscript name="2" display slide=slideshow.slides index="Biological unit" --] [a name="2" href="#_"]Biological unit[/a] [/p] [p][!--icmscript name="3" display slide=slideshow.slides index="Bfactor residues" --] [a name="3" href="#_"]Bfactor residues[/a] [/p] [p][!--icmscript name="4" display slide=slideshow.slides index="Bfactor surface" --] [a name="4" href="#_"]B-factor distribution on the surface[/a] [/p] [p][!--icmscript name="5" display slide=slideshow.slides index="Homolog superposition" --] [a name="5" href="#_"]Homolog superposition[/a] [/p] [p][!--icmscript name="6" display slide=slideshow.slides index="Ligand binding site 1" --] [a name="6" href="#_"]Ligand binding site 1[/a] [/p] [p][!--icmscript name="7" display slide=slideshow.slides index="Ligand binding site 2" --] [a name="7" href="#_"]Ligand binding site 2[/a] [/p] [p][!--icmscript name="8" display slide=slideshow.slides index="Ligand binding site 3" --] [a name="8" href="#_"]Ligand binding site 3[/a] [/p] [p][!--icmscript name="9" display slide=slideshow.slides index="Ligand binding site 4" --] [a name="9" href="#_"]Ligand binding site 4[/a] [/p] [p][!--icmscript name="10" display slide=slideshow.slides index="Ligand binding site 5" --] [a name="10" href="#_"]Ligand binding site 5[/a] [/p] [p][!--icmscript name="11" display slide=slideshow.slides index="Ligand binding site 6" --] [a name="11" href="#_"]Ligand binding site 6[/a] [/p] [p][!--icmscript name="12" display slide=slideshow.slides index="Ligand binding site 7" --] [a name="12" href="#_"]Ligand binding site 7[/a] [/p] [p][!--icmscript name="13" display slide=slideshow.slides index="Ligand binding site 8" --] [a name="13" href="#_"]Ligand binding site 8[/a] [/p] [p][!--icmscript name="14" display slide=slideshow.slides index="Ligand binding site 9" --] [a name="14" href="#_"]Ligand binding site 9[/a] [/p] [p][!--icmscript name="15" display slide=slideshow.slides index="Ligand binding site 10" --] [a name="15" href="#_"]Ligand binding site 10[/a] [/p] [p][!--icmscript name="16" display slide=slideshow.slides index="Ligand binding site 11" --] [a name="16" href="#_"]Ligand binding site 11[/a] [/p] [p][!--icmscript name="17" display slide=slideshow.slides index="Ligand binding site 12" --] [a name="17" href="#_"]Ligand binding site 12[/a] [/p] [p][!--icmscript name="18" display slide=slideshow.slides index="Ligand binding site 13" --] [a name="18" href="#_"]Ligand binding site 13[/a] [/p] [hr /] [small] [b]Controls:[/b] [table] [tr][td][b]rotate[/b][/td] [td]with the -mouse[/td][/tr] [tr][td][b]drag[/b][/td] [td] with the -mouse (or with -key pressed)[/td][/tr] [tr][td][b]zoom[/b][/td] [td] with the -mouse in the left zone of the window: zoom-up, unzoom-down[/td][/tr] [tr][td][b]clipping[/b][/td] [td] with the -mouse in the right zone of the window[/td][/tr] [/table] [p](TIP 1: Ribbon can be coloured by [!--icmscript name="m1" # display setting: color by secondary structure color ribbon Res(a_) ribbonColorStyle=1 --] [a name="m1" href="#_"]Secondary Structure[/a] or [!--icmscript name="m2" # display setting: color by NtoC color ribbon Res(a_) ribbonColorStyle=2 --] [a name="m2" href="#_"]NtoC[/a] or [!--icmscript name="m3" # display setting: color by molecule color ribbon molecule Res(a_) ribbonColorStyle=1 --] [a name="m3" href="#_"]Molecule[/a]) [/p] [p](TIP 2: the ribbon style can be changed to [!--icmscript name="r1" # display setting: normal ribbon ribbonStyle=1 --] [a name="r1" href="#_"]Normal[/a] or [!--icmscript name="r2" # display setting: smooth ribbon ribbonStyle = 5 --] [a name="r2" href="#_"]Smooth[/a]) [/p] [p](TIP 3: the background colour can be changed to [!--icmscript name="d1" # display setting: white background BKGR = "white" color background rgb={255,255,255} --] [a name="d1" href="#_"][/a] or [!--icmscript name="d2" # display setting: black background BKGR = "black" color background rgb={0,0,0} --] [a name="d2" href="#_"][/a]) [/p] [p](TIP 4: [!--icmscript name="4" display slide=slideshow.slides index="default" --] [a name="1" href="#_"]reset the view[/a]) [/p] [hr /] [p]Datapack created using [a href="http://www.molsoft.com/icm_pro.html" target="blank"]Molsoft ICM[/a] and [a href="http://www.molsoft.com/icm_browser.html" target="blank"]Molsoft Browser[/a] technologies (patent pending).[/p] [/small] [/body] [/html]  1KKJ.pdb3PGY a_3PGYB1  1KKJ3csgid.pngPNG  IHDR3 GDsRGBbKGD pHYs  tIME(/tEXtCommentCreated with GIMPW IDATxy\uugFlъц$&0#2f 8رvo`̋gy1Il !ej0l hA@;4f43˽ y}>ܞ:uN_9ν-֔Lezs2*(S)S)S)S)S)S)S)S)S)STHEϓd29TѨGLMe8}zP; DM!0MA"0 jjR"aYO?upcr2eY$qq'ZO0M;D~i"shM;TvX,J$bm!D7J%0 3Y)T)U;]׽u%!~ o7 A2{Gەx'+rO3gF=8}}<KiZ0L"hdz6n\F{,QlzHsN15%4J 7XF M5,X0 ~w-yǏm^a#LMyqR 6P@kue&hlX˜9ա㓼^wo7}} OiaFt!L 0|YL4 *+եhkɺuiiQSN9z)H=uk(55 hj+Ѩ]ǥ޶ wg(e fQ3i>P ,K\5,Zk}]:t\.˞=s$ky"4 !B5|T /L3<5Сzhhuxb?Z[] -QFR)1СG٬C.E4Rnz*&jnmx'ܼy,زe떱 )듌"vPZk,2S\xaͥeD8ٽ{@!"0W;_1 B)) =u׵n29םbl#֯U;HiຂW]xfŢ给ͮfR*e!&X8BD(xQ:;'q]l(F[ᢖ)M};DgU1Mի牦&1!,l_~3νN8ht3ط/i F17t7p'~-nn 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"""I$HT URI$$""*iUUU"$DI$I$$ $I*B$DI%UUUUIIUUURII$jDDI$JHI$DDI*HBI!$IUUUUUUUUUUI!I$DDUT"$I$DDEURUPUUUH~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 13PGYu6t u6 >t 9g?jꪪWbUT?Mj IjZjRkPP_*CZZ_IUR֪kUTR UC U$(AJR?JRZjRkPP_URIjđ"H H"DID"H$DRAIDH"H"D"$D$I"$"H$I)WW WfW#ϟDa\~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 1~binding site for residue cit c 508ac8JNV 1~binding site for residue cit d 504ac4MQY 1?333333?333333?333333???????@???o o$??`b,'I PE@?Zs?Zs?Zs??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? xLigand binding site 6KPNG  IHDRc IDATxܝwTߧLݥ-UREQK41)7To)DFcb ł pu:;F1^̜=ߙy[|09 ;8P}Om &;T@"!o&hbOzFUe5gPHDAOҧd9a3>_.441Mv-~1ًBo32dL9'M40M]tMWP5mGUS8)5A2'lfz$>Np K4s; j܍csp ;ij96#|a'[s6sJ3+ʫ 'T(;H}n躆n6m_q9 G=cbbig5kwvb&WL`Ԑxd/^WV?1nfmh)~ra'8oM8}6 mܷ_oڶ R3h@T{=Uխؾ:jwe_Om:yFt\|Q5 00cL!lxӶuS'9ٽF #bN}oHa`ߢ0EIsFl@6/^Dz-~Y{=#L@" "^O0}j[Ւgx"@M^]nu g5Mk_'npߓcH^jDmjO Em㍵O dF4Բm林 Hi~ ֑HReD2J"x۷#  BȒǽg-;fi[gxÿ'ᦕYG5W܌,hD i;~9oFDQMW%#")5~FUSz US=t%U|>. 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"""I$HT URI$$""*iUUU"$DI$I$$ $I*B$DI%UUUUIIUUURII$jDDI$JHI$DDI*HBI!$IUUUUUUUUUUI!I$DDUT"$I$DDEURUPUUUH~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 13PGYu6t u6 >t *WfUT?Mj IjZjRkPP_RZOK֩?jCCZj*)*UT?Mj RRTժJUO_CZ֠ZVC"$D$$D$"$D$I"$ $D"DDH"H"DID"H)WWWf#?UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@\~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 1~binding site for residue cit c 508ac8JNV 1~binding site for residue cit d 504ac4MQY 1?333333?333333?333333???????@???Mf^M$??G;KgO@N@?`푴?`푴?`푴??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? 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"""I$HT URI$$""*iUUU"$DI$I$$ $I*B$DI%UUUUIIUUURII$jDDI$JHI$DDI*HBI!$IUUUUUUUUUUI!I$DDUT"$I$DDEURUPUUUH~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 13PGYu6t u6 ?>t >']UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPWmUT?Mj IjZjRkPP_RZOK֩?jCCZjRjIAB J)UAZUT UU?*֫ZT+WTZ@"$D$$D$"$D$I"$ $D"DDH"H"DID"H)WW WWWf##??Iں\~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 1~binding site for residue cit c 508ac8JNV 1~binding site for residue cit d 504ac4MQY 1?333333?333333?333333???????@???\\$??`f&O7@?@q?@q?@q??@@@x@x@ ???333333?333333???#~j????333333? ףp= ?333333???@???333333?333333? 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"""I$HT URI$$""*iUUU"$DI$I$$ $I*B$DI%UUUUIIUUURII$jDDI$JHI$DDI*HBI!$IUUUUUUUUUUI!I$DDUT"$I$DDEURUPUUUH~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 13PGYu6t u6 |>t |]UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUPWmUT?Mj IjZjRkPP_RZOK֩?jCCZjUOJjIABIZJH))TjIAB J)UAVC"$D$$D$"$D$I"$ $D"DDH"H"DID"H)W WWWf#DuUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU@\~binding site for residue cit a 505ac5IMU 1~binding site for residue cit b 502ac2KOW 1vbinding site for residue gly b 509ac9g1~binding site for residue gly b 511bc2G 1~binding site for residue cit c 508ac8JNV 1~binding site for residue cit d 504ac4MQY 1?333333?333333?333333???????@???0K;f?serine hydroxymethyltransferase; chain: a, b, c, d; synonym: shmt, serine methylase; ec: 2.1.2.1; engineered: yes; mutation: yes3PGY3pgy P 21 21 21B)yBC+???abcd?????? 2AAAAHAHHHAAHHHHHHWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWWW2 t6uaa dL fUfffffffffffffffffff ffffffff ffffffff ffffffffffff fffffffff fffffffff ffffffffff fffBfffffffff fffff Bff f fffffffffffff ffffffffcVVbb dd ,fffffffffff ff ffffff ffffffff fffffffBf fffffffffff fffffffff fffffff"ff fffff fffffffffff fffff ff f fffffffffffff fffUfffcc CfB fffffffffffffffUfffff ffffffff ff fffffffffff fffffffff fffffff$ff fffff fffBfffffffcfff fffff Uf f ,fffffffffffff fffffffdd Dff ,fffffffffff ff ffffff ffffffff ffff fffffffffff ffffffffff fffffffff fffff fUffffffffff fffff ff ,f fffffUfUfUfff , fffffffK~]aacit  Xcit citric acidaa2s bbcit  te|appenXcit citric acidbbcit2  Xcit citric acidbbcit3  Xcit citric acidbb2sCpR)29bb3scccit  Xcit citric acidccedo`#)!Xedo1,2-ethanediolccedo2`=<@?AB@@D  _lys =DCEGLDFEDHGIHJIKJM  _valEMLNPSMONMQRPPT  HileNTSUW[TVUTXYWZWX\  Hala U\[]_`\^]\b  Hglu ]ab`ce`cfoabdcagbheifjgkmhlnijijp Hala cpoqstprqpu Hilequtvx|uwvuyzx{xy} Hglu v}|~}~} Harg ~ Hglu  Hphe  Hgln  Harg  Hgln  Hasn Hser  _asn Eile Eglu  _leu _ile  _ala  _ser   _glu           ! _asn " _phe $ !"# #!"%# _val%$&(+%'&%)*((,$ _ser &,+-/1,.-,0/2% Hglu -2135:243265768977;& Hala 3;:<>?;=<;@' Hval<@?ACF@BA@DECCG( HmetAGFHJNGIHGKJLKMLO) Hglu HONPRWOQPOSRTSUVTTX* Hala PXWY[\XZYX]+ Hgln Y]\^`e]_^]a`bacdbbf, _gly^fegifhgj- _ser gjikmojlkjnmp. Gvalkpoqsvprqptussw/ Gleuqwvxz~wyxw{z|}{{0 Gthrx~1 Gasn2 _lys 3 _tyr 4 _ala 5 _glu 6 _gly7 Btyr 8 _pro9 _gly: Barg ; _arg > _gly? _gly@ _cys A Hglu B Hphe   C Hval          D Hasp E Hval F Hthr !#& "! $%##'G Hglu !'&(*/')('+*,+-.,,0H Hser (0/1350210436I Hile16579=6876:;9<9:>J Hala 7>=?AB>@?>CK Hile?CBDFJCEDCGHFIFGKL HaspDKJLNRKMLKONPQOOSM Harg LSRTV]SUTSWVXWYXZY[\ZZ^N Hala T^]_ab^`_^cO Hlys _cbdfkcedcgfhgihjilP Hala dlkmoplnmlqQ HleumqprtxqsrqutvwuuyR Hphe ryxz|y{zy}|~}}~S _glyzT _ala U _glu V Ehis W EvalX EasnY _valZ _gln [ _pro\ _his ] _ser ^ Hgly_ Hpro` Hgln a Hala b Hasnc Hmetd Hala e Hval   f Htyr        g Hleu h Hval "%! #$""&i Hala  &%')*&('&+j _leu'+*,.2+-,+/.01//3k _glu ,3246;354376879:88<l _met4<;=?C<>=<@?A@BADm _gly=DCEGDFEHn _aspEHGIKOHJIHLKMNLLPo EthrIPOQSVPRQPTUSSWp EvalQWVXZ]WYXW[\ZZ^q EleuX^]_ae^`_^bacdbbfr Egly_fegifhgjs _metgjikmqjlkjnmonport _asnkrqsuyrtsrvuwxvvzu _leuszy{}z|{z~}~~v _ser {w _his  _pro _val _asn Hphe, Hser  Hgly Hlys  _phe  _tyr  Easn Ephe  Eval Eglu  _tyr            _gly  _val _asp "&! #"$%##' _lys  '&(*/')('+*,+-,.-0 _asp(0/13702104356448 _thr1879;>8:98<=;;? _glu 9?>@BG?A@?CBDCEFDDH _arg @HGIKRHJIHLKMLNMONPQOOS _ileISRTVZSUTSWXVYVW[ _asnT[Z\^b[]\[_^`a__c Htyr \cbdfncedcgfhigjgkhliljkmlo Haspdonprvoqposrtussx Hglu pwxvy{vy|wxzyw}x~{|}~ Hvaly Harg  Hlys  Hleu Hala  Hleu Hglu  Hhis  _lys  _pro _lys  Eleu Eile Eval Eala  Egly _ala        _ser       _ala  _tyr # !! "!$ _ser $#%')$&%$('* _arg %*)+-4*,+*.-/.0/1023115 _thr+5468;57659:88< _ile6<;=?C<>=<@A?B?@D _asp=DCEGKDFEDHGIJHHL Hphe ELKMOVLNMLPOQRPSPTQURUSTW Hlys MWVXZ_WYXW[Z\[]\^]` Hlys X`_ach`ba`dcedfegfi Hphe aihjlsikjimlnompmqnrorpqt Hlys jtsuw|tvutxwyxzy{z} Hglu u}|~}~} Hile~ Hala  Hasp Hglu  Hval _asn _ala  Elys  Eleu Emet Eval Easp _met Gala  Ghis  Gile Hala  Hgly Hleu          Hval  Hala  _ala  ! _gly! "$!#"% _leu"%$&(,%'&%)(*+))- _his &-,.06-/.-1023141525347 _pro.7<68:=7987;:<6;> _asn8>=?AE>@?>BACDBBF Gpro?FKEGILFHGFJIKEJM GvalGMLNPSMONMQRPPT Gglu NTSUW\TVUTXWYXZ[YY] _tyr U]\^`h]_^]a`bcadaebfcfdegfi _ala ^ihjlmikjin _aspjnmoqunponrqstrrv Ephe ovuwyvxwvzy{|z}z~{|}~ Evalw Ethr Ethr Ethr _thr _his  _lys  _thr _leu _arg  _gly _pro _arg  _gly Egly Emet Eile Eleu Ecys        _lys      Gglu  Gglu  "'! #"$#%&$$( Gtyr  (')+3(*)(,+-.,/,0-1.1/0214 Hlys )4357<46548798:9;:> Hlys 5=><?A<?BK=>@?=C>DAEBFCGDHEIFJGHL Hasp?LKMOSLNMLPOQRPPT HileMTSUW[TVUTXYWZWX\ HaspU\[]_c\^]\`_ab``d Hlys ]dcegldfedhgihjikjm Ithremlnpsmonmqrppt Iilentsuw{tvutxywzwx| Iphe u|{}|~}| Ipro} Igly Iile _gln  _gly _gly _pro _leu Hglu  Hhis  Hval Hile Hala   Hala   Hlys   Hala   Hval  Hala  Hphe      Hgly       Hglu   Hala  Hleu $! "#!!% _glu %$&(-%'&%)(*)+,**. Hasn&.-/15.0/.2134226 Hasn/6579=6876:9;<::> Hphe 7>=?AH>@?>BACDBEBFCGDGEFI Hlys ?IHJLQIKJIMLNMONPOR HthrJRQSUXRTSRVWUUY Htyr SYXZ\dY[ZY]\^_]`]a^b_b`acbe Hgln Zedfhmegfeihjikljjn Hgln fnmoqvnponrqsrtussw Hgln owvxzwyxw{z|{}~|| Hvalx Hval Hlys   Hasn! Hala " Hlys # Hval$ Hleu% Hala & Hglu ' Hala ( Hleu) Hile* Hasn+ Gglu , _gly - _phe                   . Earg                 / Eile                0 Gval     ! $    " # ! ! %1 Gser  % $ & ( * % ' & % ) ( +2 Ggly & + * , . + - , /3 _gly , / . 0 2 / 1 0 34 _thr 0 3 2 4 6 9 3 5 4 3 7 8 6 6 :5 _asp 4 : 9 ; = A : < ; : > = ? @ > > B6 _asn ; B A C E I B D C B F E G H F F J7 _his  C J I K M S J L K J N M O P N Q N R O R P Q T8 Eleu K T S U W [ T V U T X W Y Z X X \9 Eval U \ [ ] _ b \ ^ ] \ ` a _ _ c: Eala ] c b d f g c e d c h; Eval d h g i k n h j i h l m k k o< Easp i o n p r v o q p o s r t u s s w= _val p w v x z } w y x w { | z z ~> _lys  x ~ }  ~  ~ ? _gly  @ _ser A _ile  B _gly C _leu D _thr E Hgly F Hlys  G Hglu  H Hala I Hglu  J Hglu  K Hthr L Hleu M Hasp N Hser O Hval  P _gly        Q Eile         R Ethr              S _cys             T Easn      "       !   #U Elys   # " $ & + # % $ # ' & ( ' ) ( * ) ,V Easn $ , + - / 3 , . - , 0 / 1 2 0 0 4W _thr - 4 3 5 7 : 4 6 5 4 8 9 7 7 ;X _ile 5 ; : < > B ; = < ; ? @ > A > ? CY _pro < C H B D F I C E D C G F H B G JZ _phe  D J I K M T J L K J N M O P N Q N R O S P S Q R U[ _asp K U T V X \ U W V U Y X Z [ Y Y ]\ _gln  V ] \ ^ ` e ] _ ^ ] a ` b a c d b b f] _glu  ^ f e g i n f h g f j i k j l m k k o^ _lys  g o n p r w o q p o s r t s u t v u x_ _pro p x } w y { ~ x z y x | { } w | ` _phe  y  ~   a _val b _thr c _ser d Egly e Eile f Earg  g Eleu h Egly i _thr j Hpro k Hala l Hala m Hthr n Hthr o _arg  p _gly q _phe  r _asp               s _glu          t _lys                   u Hala           v Hphe    ! # * " ! $ # % & $ ' $ ( % ) & ) ' ( ,w Hglu ! + , * - / * - 0 9 + , . - + 1 , 2 / 3 0 4 1 5 7 2 6 8 3 4 3 4 :x Hglu  - : 9 ; = B : < ; : > = ? > @ A ? ? Cy Hval ; C B D F I C E D C G H F F Jz Hala D J I K M N J L K J O{ Hlys  K O N P R W O Q P O S R T S U T V U X| Hile P X W Y [ _ X Z Y X \ ] [ ^ [ \ `} Hile Y ` _ a c g ` b a ` d e c f c d h~ Hser a h g i k m h j i h l k n Hleu i n m o q u n p o n r q s t r r v Hala o v u w y z v x w v { Hleu w { z | ~ { } | {  ~    Hlys  |  _asn  _ser  _lys   _asp  Hglu   Hglu   Hlys   Hleu  Hgln   Hgln   Hala  Hlys   Hglu   Harg    Hval               Hala    Hlys                   Hleu                  Hthr    " %  !  # $ " " & Hala & % ' ) * & ( ' & + Hglu  ' + * , . 3 + - , + / . 0 / 1 2 0 0 4 _tyr  , 4 3 5 7 ? 4 6 5 4 8 7 9 : 8 ; 8 < 9 = : = ; < > = @ _pro 5 @ E ? A C F @ B A @ D C E ? D G _leu A G F H J N G I H G K J L M K K O _tyr  H O N P R Z O Q P O S R T U S V S W T X U X V W Y X [ _gln  P [ Z \ ^ [ ] c \ [ _ ^ ` _ a b ` ` \ e _met e d f h l e g f e i h j i k j m Hser f m l n p r m o n m q p s Htyr  n s r t v ~ s u t s w v x y w z w { x | y | z { } |  Hile t  ~     Hthr   Hlys    Hgln    _asp   Hlys    Hval   Hile   Hala   Hglu    Hala   Hile   Hglu    Harg    Hglu    Hphe       Hgln                 Harg                   Hgln                    _asn   ! # ' " ! $ # % & $ $ ) _ser  ! ( ) ' * , ' * - 0 ( ) + * ( . ) / , - 1 _asn * 1 0 2 4 8 1 3 2 1 5 4 6 7 5 5 9 Eile 2 9 8 : < @ 9 ; : 9 = > < ? < = B Eglu : A B @ C E @ C F O A B D C A G B H E I F J G K M H L N I J I J P _leu C P O Q S W P R Q P T S U V T T X _ile Q X W Y [ _ X Z Y X \ ] [ ^ [ \ ` _ala Y ` _ a c d ` b a ` e _ser a e d f h j e g f e i h k  _glu  f k j l n s k m l k o n p o q r p p t! _asn l t s u w { t v u t x w y z x x |" _phe  u | { }  | ~ } |   # _val }  $ _ser  % Hglu   & Hala  ' Hval  ( Hmet  ) Hglu   * Hala  + Hgln   , _gly  - _ser  . Gval  / Gleu  0 Gthr  1 Gasn  2 _lys   3 _tyr      4 _ala   5 _glu          6 Egly 7 Etyr "  ! #8 _pro#("$&)#%$#'&("'*9 _gly$*)+-*,+.: Earg +.-/18.0/.2132435467559; Earg /98:<C9;:9=<>=?>@?AB@@D< _tyr :DCEGODFEDHGIJHKHLIMJMKLNMP= _tyr EPOQS[PRQPTSUVTWTXUYVYWXZY\> _glyQ\[]_\^]`? _gly]`_ac`bad@ _cys adcegidfedhgkA Hglu ejkilniloxjkmljpkqnrosptvquwrsrsyB Hphe lyxz|y{zy}|~}}~C HvalzD HaspE HvalF HthrG Hglu H Hser I HileJ Hala K HileL HaspM Harg N Hala O Hlys P Hala Q HleuR Hphe S _glyT _ala U _glu          V Ehis W Eval !X Easn! "$(!#"!%$&'%%)Y _val")(*,/)+*)-.,,0Z _gln *0/1380210435467559[ _pro19>8:<?9;:9=<>8=@\ _his :@?ACI@BA@DCEFDGDHEHFGJ] _ser AJIKMOJLKJNMP^ HglyKPOQSPRQT_ HproQTYSUWZTVUTXWYSX[` Hgln U[Z\^c[]\[_^`_ab``da Hala \dceghdfedib Hasneihjlpikjimlnommqc Hmetjqprtxqsrqutvuwvyd Hala ryxz|}y{zy~e Hvalz~}~~f Htyr g Hleuh Hvali Hala j _leuk _glu l _metm _glyn _aspo Ethrp Evalq Eleur Eglys Emett _asnu _leuv _ser w _his       _ala        _pro  _val _asn "&! #"$%##( Hphe, '(&)+&),9'(*)'-(.+/1,02-3.4-5.6/70817283546: Hser ):9;=?:<;:>=@ Hgly;@?AC@BAD Hlys ADCEGLDFEDHGIHJIKJM _phe EMLNPWMONMQPRSQTQURVSVTUX _tyr NXWY[cXZYX\[]^\_\`]a^a_`bad EasnYdcegkdfedhgijhhl Ephe elkmovlnmlpoqrpsptqurustw Evalmwvxz}wyxw{|zz~ Eglu x~}~~ Etyr  _gly _val _asp _lys  _asp _thr _glu  _arg  _ile _asn Htyr  Hasp Hglu  Hval Harg             Hlys  Hleu! 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GvalBGFHJMGIHGKLJJN/ GleuHNMOQUNPONRQSTRRV0 GthrOVUWY\VXWVZ[YY]1 GasnW]\^`d]_^]a`bcaae2 _lys ^edfhmegfeihjikjlkn3 _tyr fnmoqynponrqstrurvswtwuvxwz4 _ala ozy{}~z|{z5 _glu {~6 _gly7 _tyr 8 _pro9 _gly: _arg(; _arg > _gly? _gly@ _cys A Hglu B Hphe C HvalD HaspE HvalF HthrG Hglu  H Hser          I Hile J Hala K Hile# !" $L Hasp$#%'+$&%$(')*((,M Harg %,+-/6,.-,0/10213245337N Hala -768:;7987<O Hlys 8<;=?D<>=<@?A@BACBEP Hala =EDFHIEGFEJQ HleuFJIKMQJLKJNMOPNNRR Hphe KRQSU\RTSRVUWXVYVZW[X[YZ]S _glyS]\^`]_^aT _ala ^a`bdeacbafU _glu bfeginfhgfjikjlmkkoV Ehis gonprxoqposrtusvswtwuvyW Evalpyxz|y{zy}~||X EasnzY _valZ _gln [ _pro\ _his ] _ser ^ Hgly_ Hpro` Hgln a Hala b Hasnc Hmetd Hala e Hvalf Htyr0g Hleuh Hvali Hala       j _leu     k _glu l _met!% "!#"$#&m _gly&%')&('*n _asp'*)+-1*,+*.-/0..2o Ethr+21358243267559p Eval398:<?9;:9=><<@q Eleu:@?ACG@BA@DCEFDDHr EglyAHGIKHJILs EmetILKMOSLNMLPOQPRQTt _asnMTSUWTVUTXWYZXX\ _val \[]_b\^]\`a__c _asn]cbdfjcedcgfhiggl Hphe,dkljmojmp}klnmkqlrosuptvqwrxqyrzs{t|u{v|wyxz~ Hser m~}~~ Hgly Hlys  _phe  _tyr  Easn Ephe  Eval Eglu  Etyr  _gly _val _asp _lys  _asp _thr _glu     _arg         _ile  _asn!% "!#$""& Htyr &%')1&('&*)+,*-*.+/,/-.0/3 Hasp '23146147>235428396:<7;=8989@ Hglu 4?@>AC>ADM?@BA?E@FCGDHEIKFJLGHGHN HvalANMOQTNPONRSQQU Harg OUTVX_UWVUYXZY[Z\[]^\\a Hlys V`a_bd_ben`acb`fagdheifjgkhlimjko Hleubonprvoqposrtussw Hala pwvxz{wyxw| Hleux|{}|~}| Hglu } Hhis  _lys  _pro _lys  Eleu Eile Eval Eala  Egly _ala  _ser  _ala  _tyr  _ser  _arg  _thr _ile     _asp       Hphe   Hlys  "'! #"$#%$&%( Hlys  (')+0(*)(,+-,.-/.1 Hphe )1024;1321546758596:7:89< Hlys 2<;=?D<>=<@?A@BACBE Hglu =EDFHMEGFEIHJIKLJJN HileFNMOQUNPONRSQTQRV Hala OVUWYZVXWV[ HaspW[Z\^b[]\[_^`a__c Hglu \cbdfkcedcgfhgijhhl _valdlkmorlnmlpqoos _asnmsrtvzsutswvxyww{ _ala t{z|~{}|{ Elys | Eleu Emet Eval Easp _met _ala  _his  _ile Hala  Hgly Hleu Hval Hala  _ala  _gly _leu _his  _pro _asn         _pro   _val _glu  !*"# $!%"&(#')$%$%+ _tyr +*,.6+-,+/.01/2/3041423547 _ala ,768:;7987< _asp8<;=?C<>=<@?AB@@D Ephe =DCEGNDFEDHGIJHKHLIMJMKLO EvalEONPRUOQPOSTRRV EthrPVUWY\VXWVZ[YY] EthrW]\^`c]_^]ab``d Ethr^dcegjdfedhiggk _threkjlnqkmlkopnnr _his lrqsu{rtsrvuwxvyvzwzxy| Glys s|{}|~}| Gthr} Gleu _arg  _gly _pro _arg  _gly Egly Emet Eile Eleu Ecys  _lys  _glu  _glu  _tyr     Hlys                         Hlys                                  Hasp   ! # ' " ! $ # % & $ $ ( Hile ! 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Hgly"]"e"d"f"h"e"g"f"i@ Hser "f"i"h"j"l"n"i"k"j"i"m"l"oA Hile"j"o"n"p"r"v"o"q"p"o"s"t"r"u"r"s"wB _gly"p"w"v"x"z"w"y"x"|C _leu "x"{"|"z"}""z"}"""{"|"~"}"{""|""""""""""""D _thr"}""""""""""""""E Hgly"""""""""F Hlys """""""""""""""""""G Hglu """""""""""""""""""H Hala """""""""""I Hglu """""""""""""""""""J Hglu """""""""""""""""""""""""""""""""K Hthr"""""""""""""""L Hleu"""""""""""""""""M Hasp"""""""""""""""""N Hser """""""""""""O Hval"""""""""""""""P _gly"""""""""Q Eile"""""""""""""""""R Ethr"""""""""""""""S _cys """""""""""""T Basn"""###"##"#######U _lys ##### ### ### # # # # # ## #V _asn #############################W _thr##### #######!#"# # #$X _ile##$###%#'#+#$#&#%#$#(#)#'#*#'#(#,Y _pro#%#,#1#+#-#/#2#,#.#-#,#0#/#1#+#0#3Z _phe #-#3#2#4#6#=#3#5#4#3#7#6#8#9#7#:#7#;#8#<#9#<#:#;#>[ _asp#4#>#=#?#A#E#>#@#?#>#B#A#C#D#B#B#F\ _gln #?#F#E#G#I#N#F#H#G#F#J#I#K#J#L#M#K#K#O] _glu #G#O#N#P#R#W#O#Q#P#O#S#R#T#S#U#V#T#T#X^ _lys #P#X#W#Y#[#`#X#Z#Y#X#\#[#]#\#^#]#_#^#a_ _pro#Y#a#f#`#b#d#g#a#c#b#a#e#d#f#`#e#h` _phe #b#h#g#i#k#r#h#j#i#h#l#k#m#n#l#o#l#p#m#q#n#q#o#p#sa _val#i#s#r#t#v#y#s#u#t#s#w#x#v#v#zb _thr#t#z#y#{#}##z#|#{#z#~##}#}#c _ser #{############d _gly#########e Eile#################f Earg #######################g Eleu#################h Egly#########i _thr###############j Hpro#################k Hala ###########l Hala ###########m Hthr###############n Hthr###############o _arg #######################p _gly#########q _phe #########################r _asp#################s Hglu #########$######################$t Hlys #$$$$$ $$$$$$$$$$$$$ u Hala $$ $ $ $ $$ $ $ $ $v Hphe $ $$$$$$$$$$$$$$$$$$$$$$$$w Hglu $$$$$$"$$$$$$$$$ $!$$$#x Hglu $$#$"$$$&$+$#$%$$$#$'$&$($'$)$*$($($,y Hval$$$,$+$-$/$2$,$.$-$,$0$1$/$/$3z Hala $-$3$2$4$6$7$3$5$4$3$8{ Hlys $4$8$7$9$;$@$8$:$9$8$<$;$=$<$>$=$?$>$A| Hile$9$A$@$B$D$H$A$C$B$A$E$F$D$G$D$E$I} Hile$B$I$H$J$L$P$I$K$J$I$M$N$L$O$L$M$Q~ Hser $J$Q$P$R$T$V$Q$S$R$Q$U$T$W Hleu$R$W$V$X$Z$^$W$Y$X$W$[$Z$\$]$[$[$_ Hala $X$_$^$`$b$c$_$a$`$_$d Hleu$`$d$c$e$g$k$d$f$e$d$h$g$i$j$h$h$l Glys $e$l$k$m$o$t$l$n$m$l$p$o$q$p$r$q$s$r$u Gasn$m$u$t$v$x$|$u$w$v$u$y$x$z${$y$y$} _ser $v$}$|$~$$$}$$~$}$$$ _lys $~$$$$$$$$$$$$$$$$$$ _asp$$$$$$$$$$$$$$$$$ Hglu $$$$$$$$$$$$$$$$$$$ Hglu $$$$$$$$$$$$$$$$$$$ Hlys $$$$$$$$$$$$$$$$$$$ Hleu$$$$$$$$$$$$$$$$$ Hgln $$$$$$$$$$$$$$$$$$$ Hgln $$$$$$$$$$$$$$$$$$$ Hala $$$$$$$$$$$ Hlys $$$$$$$$$$$$$$$$$$$ Hglu $$$$$$$$$$$$$$$$$$$ Harg $$$$$$$$$$$$$$$$$$$$$$$ Hval$$$$$$$$$$$$$$$ Hala $$$$$$$$$$$ Hlys $$$$$$$$$%$$$$$$$$$$$%$%$%$%%%%%% Hleu$%%%% % %%%%% % % % % % % Hthr%%% %%%%%%%%%%%% Hala %%%%%%%%%%% Hglu %%%%%%"%%%%%%%%% %!%%%# _tyr %%#%"%$%&%.%#%%%$%#%'%&%(%)%'%*%'%+%(%,%)%,%*%+%-%,%/ _pro%$%/%4%.%0%2%5%/%1%0%/%3%2%4%.%3%6 _leu%0%6%5%7%9%=%6%8%7%6%:%9%;%<%:%:%> _tyr %7%>%=%?%A%>%@%?%>%B%A%C%D%B%E%B%F%C%G%D%G%E%F%H%G%J _asn%J%I%K%M%Q%J%L%K%J%N%M%O%P%N%N%R _ala %K%R%Q%S%U%V%R%T%S%R%W _met%S%W%V%X%Z%^%W%Y%X%W%[%Z%\%[%]%\%_ Hser %X%_%^%`%b%d%_%a%`%_%c%b%e Htyr %`%e%d%f%h%p%e%g%f%e%i%h%j%k%i%l%i%m%j%n%k%n%l%m%o%n%q Hile%f%q%p%r%t%x%q%s%r%q%u%v%t%w%t%u%y Hthr%r%y%x%z%|%%y%{%z%y%}%~%|%|% _lys %z%%%%%%%%%%%%%%%%%% _gln %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% _asp%%%%%%%%%%%%%%%%%  Hlys %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%  Hval%%%%%%%%%%%%%%%  Hile%%%%%%%%%%%%%%%%%  Hala %%%%%%%%%%%  Hglu %%%%%%%%%%%%%%%%%%% Hala %%%%%%%%%%% Hile%%%%%%%%%%%%%%%%% Hglu %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% Harg %%%%%%%%%%%%%%%%%%%%%%% Hglu %%%%%%%%%%%%%%%%%%% Hphe %%%%%&%%%%&%&&&&&&&&&&&&& Hgln %&&&& &&& &&& & & & & && & & Harg &&&&&&&&&&&&&&&&&&&&&&& Hgln &&&&&&#&&&&&&& &&!&"& & &$ _asn&&$&#&%&'&+&$&&&%&$&(&'&)&*&(&(&- _ser &%&,&-&+&.&0&+&.&1&4&,&-&/&.&,&2&-&3&0&1&6 _asn &.&5&6&4&7&9&4&7&:&A&5&6&8&7&5&;&6&<&9&=&?&:&>&@&;&<&;&<&B _ile&7&B&A&C&E&I&B&D&C&B&F&G&E&H&E&F&K _glu &C&J&K&I&L&N&I&L&O&X&J&K&M&L&J&P&K&Q&N&R&O&S&P&T&V&Q&U&W&R&S&R&S&Y _leu&L&Y&X&Z&\&`&Y&[&Z&Y&]&\&^&_&]&]&a Bile&Z&a&`&b&d&h&a&c&b&a&e&f&d&g&d&e&i _ala &b&i&h&j&l&m&i&k&j&i&n _ser &j&n&m&o&q&s&n&p&o&n&r&q&t  _glu &o&t&s&u&w&|&t&v&u&t&x&w&y&x&z&{&y&y&}! _asn&u&}&|&~&&&}&&~&}&&&&&&&" _phe &~&&&&&&&&&&&&&&&&&&&&&&&&# _val&&&&&&&&&&&&&&&$ _ser &&&&&&&&&&&&&% Hglu &&&&&&&&&&&&&&&&&&&& Hala &&&&&&&&&&&' Hval&&&&&&&&&&&&&&&( Hmet&&&&&&&&&&&&&&&&&) Hglu &&&&&&&&&&&&&&&&&&&* Hala &&&&&&&&&&&+ Hgln &&&&&&&&&&&&&&&&&&&, _gly&&&&&&&&&- _ser &&&&&&&&&&&&&. Gval&&&&&&&&&&&&&&&/ Gleu&&&&&&&&&&&&&&&&&0 Gthr&&&&&&&&&&&&&&&1 Gasn&&&&&&&&&&&&&&&&&2 _lys &&&&&'&&&&&&&&&&'&'3 _tyr &''''' '''''''''' '' '' '' ' ' ' ' '4 _ala ''' ''''''''5 _glu '''''''''''''''''''6 Egly''''''''' 7 Etyr '' ''!'#'+' '"'!' '$'#'%'&'$'''$'('%')'&')'''('*')',8 _pro'!','1'+'-'/'2','.'-','0'/'1'+'0'39 _gly'-'3'2'4'6'3'5'4'7: Earg '4'7'6'8':'A'7'9'8'7';':'<';'='<'>'='?'@'>'>'B; Earg '8'B'A'C'E'L'B'D'C'B'F'E'G'F'H'G'I'H'J'K'I'I'M< _tyr 'C'M'L'N'P'X'M'O'N'M'Q'P'R'S'Q'T'Q'U'R'V'S'V'T'U'W'V'Y= _tyr 'N'Y'X'Z'\'d'Y'['Z'Y']'\'^'_']'`']'a'^'b'_'b'`'a'c'b'e> _gly'Z'e'd'f'h'e'g'f'i? _gly'f'i'h'j'l'i'k'j'm@ _cys 'j'm'l'n'p'r'm'o'n'm'q'p'tA Hglu 'n's't'r'u'w'r'u'x''s't'v'u's'y't'z'w'{'x'|'y'}''z'~''{'|'{'|'B Hphe 'u''''''''''''''''''''''''C Hval'''''''''''''''D Hasp'''''''''''''''''E Hval'''''''''''''''F Hthr'''''''''''''''G Hglu '''''''''''''''''''H Hser '''''''''''''I Hile'''''''''''''''''J Hala '''''''''''K Hile'''''''''''''''''L Hasp'''''''''''''''''M Harg '''''''''''''''''''''''N Hala '''''''''''O Hlys '''''''''''''''''''P Hala '''''''''''Q Hleu'''''''''''''''''R Hphe '''''(''''('(((((((((((((S _gly'(((( (( (( T _ala (( ( ( ((( ( ( ( (U _glu ( ((((((((((((((((((V Ehis (((((("(((((((((( ((!((!(( (#W Eval((#("($(&()(#(%($(#('(((&(&(*X Easn($(*()(+(-(1(*(,(+(*(.(-(/(0(.(.(2Y _val(+(2(1(3(5(8(2(4(3(2(6(7(5(5(9Z _gln (3(9(8(:(<(A(9(;(:(9(=(<(>(=(?(@(>(>(B[ _pro(:(B(G(A(C(E(H(B(D(C(B(F(E(G(A(F(I\ _his (C(I(H(J(L(R(I(K(J(I(M(L(N(O(M(P(M(Q(N(Q(O(P(S] _ser (J(S(R(T(V(X(S(U(T(S(W(V(Y^ Hgly(T(Y(X(Z(\(Y([(Z(]_ Hpro(Z(](b(\(^(`(c(](_(^(](a(`(b(\(a(d` Hgln (^(d(c(e(g(l(d(f(e(d(h(g(i(h(j(k(i(i(ma Hala (e(m(l(n(p(q(m(o(n(m(rb Hasn(n(r(q(s(u(y(r(t(s(r(v(u(w(x(v(v(zc Hmet(s(z(y({(}((z(|({(z(~(}((~(((d Hala ({((((((((((e Hval(((((((((((((((f Htyr0(((((((((((((((((((((((((((((((((((((((((((((((((g Hleu(((((((((((((((((h Hval(((((((((((((((i Hala (((((((((((j _leu(((((((((((((((((k _glu (((((((((((((((((((l _met(((((((((((((((((m _gly(((((((((n _asp(((((((((((((((((o Ethr(((((((((((((((p Eval(((((((((((((((q Eleu(((((((((((((((((r Egly(((((((((s Emet(((((((((((((((((t _asn(((()()(())))))) _pro)) ))) ) ))))) ) ) )) )  _val)) ) )))) ))) ))))) _asn))))))))))))))))) Hphe ))))))&))))) ))!)") )#) )$)!)%)")%)#)$)' Hser ))')&)()*),)')))()')+)*)- Hgly)()-),).)0)-)/).)1 Hlys ).)1)0)2)4)9)1)3)2)1)5)4)6)5)7)6)8)7): _phe )2):)9);)=)D):)<);):)>)=)?)@)>)A)>)B)?)C)@)C)A)B)E _tyr );)E)D)F)H)P)E)G)F)E)I)H)J)K)I)L)I)M)J)N)K)N)L)M)O)N)Q Easn)F)Q)P)R)T)X)Q)S)R)Q)U)T)V)W)U)U)Y Ephe )R)Y)X)Z)\)c)Y)[)Z)Y)])\)^)_)])`)])a)^)b)_)b)`)a)d Eval)Z)d)c)e)g)j)d)f)e)d)h)i)g)g)k Eglu )e)k)j)l)n)s)k)m)l)k)o)n)p)o)q)r)p)p)t Etyr )l)t)s)u)w))t)v)u)t)x)w)y)z)x){)x)|)y)})z)}){)|)~)}) _gly)u)))))))) _val))))))))))))))) _asp))))))))))))))))) _lys ))))))))))))))))))) _asp))))))))))))))))) _thr))))))))))))))) _glu ))))))))))))))))))) _arg ))))))))))))))))))))))) _ile))))))))))))))))) _asn))))))))))))))))) Htyr ))))))))))))))))))))))))))) Hasp))))))))))))))))) Hglu ))))))))))))))))))) Hval))))))))))))))) Harg ))))))))))))))))))))))) Hlys ))))**)*))********* Hleu)**** *** *** * * * * * * Hala *********** Hleu***************** Hglu ******$***** **!* *"*#*!*!*% Hhis **%*$*&*(*.*%*'*&*%*)*(***+*)*,*)*-***-*+*,*/ _lys *&*/*.*0*2*7*/*1*0*/*3*2*4*3*5*4*6*5*8 _pro*0*8*=*7*9*;*>*8*:*9*8*<*;*=*7*<*? _lys *9*?*>*@*B*G*?*A*@*?*C*B*D*C*E*D*F*E*H Eleu*@*H*G*I*K*O*H*J*I*H*L*K*M*N*L*L*P Eile*I*P*O*Q*S*W*P*R*Q*P*T*U*S*V*S*T*X Eval*Q*X*W*Y*[*^*X*Z*Y*X*\*]*[*[*_ Eala *Y*_*^*`*b*c*_*a*`*_*d Egly*`*d*c*e*g*d*f*e*h _ala *e*h*g*i*k*l*h*j*i*h*m _ser *i*m*l*n*p*r*m*o*n*m*q*p*s _ala *n*s*r*t*v*w*s*u*t*s*x _tyr *t*x*w*y*{**x*z*y*x*|*{*}*~*|**|**}**~****** _ser *y************ _arg *********************** _thr*************** _ile***************** _asp***************** Hphe ************************* Hlys ******************* Hlys ******************* Hphe ************************* Hlys ******************* Hglu ******************* Hile***************** Hala *********** Hasp***************** Hglu *****+******+*+++++ _val*+++++ ++++++ +++  _asn++ + + +++ + + + +++++++ _ala + ++++++++++ Elys ++++++ +++++++++++++! Eleu++!+ +"+$+(+!+#+"+!+%+$+&+'+%+%+) Emet+"+)+(+*+,+0+)+++*+)+-+,+.+-+/+.+1 Eval+*+1+0+2+4+7+1+3+2+1+5+6+4+4+8 Easp+2+8+7+9+;+?+8+:+9+8+<+;+=+>+<+<+@ _met+9+@+?+A+C+G+@+B+A+@+D+C+E+D+F+E+H Gala +A+H+G+I+K+L+H+J+I+H+M Ghis +I+M+L+N+P+V+M+O+N+M+Q+P+R+S+Q+T+Q+U+R+U+S+T+W Gile+N+W+V+X+Z+^+W+Y+X+W+[+\+Z+]+Z+[+_ Hala +X+_+^+`+b+c+_+a+`+_+d Hgly+`+d+c+e+g+d+f+e+h Hleu+e+h+g+i+k+o+h+j+i+h+l+k+m+n+l+l+p Hval+i+p+o+q+s+v+p+r+q+p+t+u+s+s+w Hala +q+w+v+x+z+{+w+y+x+w+| _ala +x+|+{+}+++|+~+}+|+ _gly+}++++++++ _leu+++++++++++++++++ _his +++++++++++++++++++++++ _pro+++++++++++++++++ _asn+++++++++++++++++ Gpro+++++++++++++++++ Gval+++++++++++++++ Gglu +++++++++++++++++++ _tyr +++++++++++++++++++++++++++ _ala +++++++++++ _asp+++++++++++++++++ Ephe +++++++++++++++++++++++++ Eval+++++++++++++++ Ethr+++++++++++++++ Ethr+++++++++++++++ Ethr+++++++++++++++ _thr++++,,++++,,,,, _his +,,,,, ,,,,,,, , ,, ,, , , , , , Glys ,,, ,,,,,,,,,,,,,,,, Gthr,,,,,,,,,,,,,,, Gleu,,,,,!,%,, ,,,",!,#,$,",",& _arg ,,&,%,',),0,&,(,',&,*,),+,*,,,+,-,,,.,/,-,-,1 _gly,',1,0,2,4,1,3,2,5 _pro,2,5,:,4,6,8,;,5,7,6,5,9,8,:,4,9,< _arg ,6,<,;,=,?,F,<,>,=,<,@,?,A,@,B,A,C,B,D,E,C,C,G _gly,=,G,F,H,J,G,I,H,K Egly,H,K,J,L,N,K,M,L,O Emet,L,O,N,P,R,V,O,Q,P,O,S,R,T,S,U,T,W Eile,P,W,V,X,Z,^,W,Y,X,W,[,\,Z,],Z,[,_ Eleu,X,_,^,`,b,f,_,a,`,_,c,b,d,e,c,c,g Ecys ,`,g,f,h,j,l,g,i,h,g,k,j,m _lys ,h,m,l,n,p,u,m,o,n,m,q,p,r,q,s,r,t,s,w Gglu ,n,v,w,u,x,z,u,x,{,,v,w,y,x,v,|,w,},z,~,{,,|,,,},,,~,,~,, Gglu ,x,,,,,,,,,,,,,,,,,, Gtyr ,,,,,,,,,,,,,,,,,,,,,,,,,,, Hlys ,,,,,,,,,,,,,,,,,,, Hlys ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Hasp,,,,,,,,,,,,,,,,, Hile,,,,,,,,,,,,,,,,, Hasp,,,,,,,,,,,,,,,,, Hlys ,,,,,,,,,,,,,,,,,,, Ithr,,,,,,,,,,,,,,, Iile,,,,,,,,,,,,,,,,, Iphe ,,,,,,,,,,,,,,,,,,,,,,,,, Ipro,,,,,,,,,,,,,,,,, Igly,,,,,,,,, Iile,,,,,,,,,,,,,,,,- _gln ,-,----------------  _gly-- -- - - - - -  _gly- - - --- --- _pro----------------- _leu-----------------  Hglu -- --!-#-(- -"-!- -$-#-%-$-&-'-%-%-) Hhis -!-)-(-*-,-2-)-+-*-)---,-.-/---0---1-.-1-/-0-3 Hval-*-3-2-4-6-9-3-5-4-3-7-8-6-6-: Hile-4-:-9-;-=-A-:-<-;-:->-?-=-@-=->-B Hala -;-B-A-C-E-F-B-D-C-B-G  Hala -C-G-F-H-J-K-G-I-H-G-L  Hlys -H-L-K-M-O-T-L-N-M-L-P-O-Q-P-R-Q-S-R-U  Hala -M-U-T-V-X-Y-U-W-V-U-Z  Hval-V-Z-Y-[-]-`-Z-\-[-Z-^-_-]-]-a  Hala -[-a-`-b-d-e-a-c-b-a-f Hphe -b-f-e-g-i-p-f-h-g-f-j-i-k-l-j-m-j-n-k-o-l-o-m-n-q Hgly-g-q-p-r-t-q-s-r-u Hglu -r-u-t-v-x-}-u-w-v-u-y-x-z-y-{-|-z-z-~ Hala -v-~-}----~---~- _leu----------------- _glu ------------------- Hasn----------------- Hasn----------------- Hphe ------------------------- Hlys ------------------- Hthr--------------- Htyr --------------------------- Hgln ------------------- Hgln ------------------- Hgln ------------------- Hval--------------- Hval--------------- Hlys ---------.-----------------.-.--.  Hasn-..... ........ ... ! Hala .. . . ... . . . ." Hlys . ..................# Hval............... $ Hleu.. ..!.#.'. .".!. .$.#.%.&.$.$.(% Hala .!.(.'.).+.,.(.*.).(.-& Hglu .).-.,...0.5.-./...-.1.0.2.1.3.4.2.2.6' Hala ...6.5.7.9.:.6.8.7.6.;( Hleu.7.;.:.<.>.B.;.=.<.;.?.>.@.A.?.?.C) Hile.<.C.B.D.F.J.C.E.D.C.G.H.F.I.F.G.K* Hasn.D.K.J.L.N.R.K.M.L.K.O.N.P.Q.O.O.S+ _glu .L.S.R.T.V.[.S.U.T.S.W.V.X.W.Y.Z.X.X.\, _gly.T.\.[.]._.\.^.].`- _phe .].`._.a.c.j.`.b.a.`.d.c.e.f.d.g.d.h.e.i.f.i.g.h.k. Earg .a.k.j.l.n.u.k.m.l.k.o.n.p.o.q.p.r.q.s.t.r.r.v/ Eile.l.v.u.w.y.}.v.x.w.v.z.{.y.|.y.z.~0 Gval.w.~.}....~...~.....1 Gser .............2 Ggly.........3 _gly.........4 _thr...............5 _asp.................6 _asn.................7 _his .......................8 Eleu.................9 Eval...............: Eala ...........; Eval...............< Easp.................= _val...............> Hlys ...................? Hgly.........@ Hser .............A Hile.................B _gly.........C _leu....//....///////D _thr.///// ///// / /// E _gly// / / // // /F _lys / //////////////////G Hglu //////!////////// ///"H Hala //"/!/#/%/&/"/$/#/"/(I Hglu /#/'/(/&/)/+/&/)/,/5/'/(/*/)/'/-/(/./+///,/0/-/1/3/./2/4///0///0/6J Hglu /)/6/5/7/9/>/6/8/7/6/:/9/;/:/</=/;/;/?K Hthr/7/?/>/@/B/E/?/A/@/?/C/D/B/B/FL Hleu/@/F/E/G/I/M/F/H/G/F/J/I/K/L/J/J/NM Hasp/G/N/M/O/Q/U/N/P/O/N/R/Q/S/T/R/R/VN Hser /O/V/U/W/Y/[/V/X/W/V/Z/Y/\O Hval/W/\/[/]/_/b/\/^/]/\/`/a/_/_/cP _gly/]/c/b/d/f/c/e/d/gQ _ile/d/g/f/h/j/n/g/i/h/g/k/l/j/m/j/k/pR _thr /h/o/p/n/q/s/n/q/t/y/o/p/r/q/o/u/w/p/v/x/s/t/s/t/zS _cys /q/z/y/{/}//z/|/{/z/~/}/T _asn/{////////////////U _lys ///////////////////V Basn/////////////////W _thr///////////////X _ile/////////////////Y _pro/////////////////Z _phe /////////////////////////[ _asp/////////////////\ _gln /////////////////////////////////] _glu ///////////////////^ _lys /////////////////////////////////_ _pro/////////////////` _phe,/////////0///////////////////////0/0/0/0////0a _val/00000 000000000 b _thr00 0 0 0 00 0 0 0 000 0 0c _ser 0 000000000000d Egly000000000e Eile000000"000000 00!000$f Earg(00#0$0"0%0'0"0%0(050#0$0&0%0#0)0$0*0'0+0(0,0)0-0*0.0+0/0,000-01030.02040/000/0006g Eleu0%060507090=060807060:090;0<0:0:0>h Egly070>0=0?0A0>0@0?0Bi _thr0?0B0A0C0E0H0B0D0C0B0F0G0E0E0Ij Hpro0C0I0N0H0J0L0O0I0K0J0I0M0L0N0H0M0Pk Hala 0J0P0O0Q0S0T0P0R0Q0P0Ul Hala 0Q0U0T0V0X0Y0U0W0V0U0Zm Hthr0V0Z0Y0[0]0`0Z0\0[0Z0^0_0]0]0an Hthr0[0a0`0b0d0g0a0c0b0a0e0f0d0d0ho Harg 0b0h0g0i0k0r0h0j0i0h0l0k0m0l0n0m0o0n0p0q0o0o0sp _gly0i0s0r0t0v0s0u0t0wq _phe 0t0w0v0x0z00w0y0x0w0{0z0|0}0{0~0{00|00}00~00r _asp0x0000000000000000s Hglu 0000000000000000000t Hlys 0000000000000000000u Hala 00000000000v Hphe 0000000000000000000000000w Hglu 0000000000000000000x Hglu 0000000000000000000y Hval000000000000000z Hala 00000000000{ Hlys 0000000000000000000| Hile00000000000000000} Hile00000000000000000~ Hser 0000000000000 Hleu00000000000000000 Hala 00000000000 Hleu00000000000000000 Glys 0000110100111111111 Gasn01111 111 111 1 1 1 1 1 1 _ser 1111111111111 _lys 1111111111111111111 _asp11111!1%11 111"1!1#1$1"1"1& Hglu 11&1%1'1)1.1&1(1'1&1*1)1+1*1,1-1+1+1/ Hglu 1'1/1.1012171/11101/131214131516141418 Hlys 101817191;1@181:19181<1;1=1<1>1=1?1>1A Hleu191A1@1B1D1H1A1C1B1A1E1D1F1G1E1E1I Hgln 1B1I1H1J1L1Q1I1K1J1I1M1L1N1M1O1P1N1N1R Hgln 1J1R1Q1S1U1Z1R1T1S1R1V1U1W1V1X1Y1W1W1[ Hala 1S1[1Z1\1^1_1[1]1\1[1` Hlys 1\1`1_1a1c1h1`1b1a1`1d1c1e1d1f1e1g1f1i Hglu 1a1i1h1j1l1q1i1k1j1i1m1l1n1m1o1p1n1n1r Harg 1j1r1q1s1u1|1r1t1s1r1v1u1w1v1x1w1y1x1z1{1y1y1} Hval1s1}1|1~111}11~1}11111 Hala 1~1111111111 Hlys 1111111111111111111 Hleu11111111111111111 Hthr111111111111111 Hala 11111111111 Hglu 1111111111111111111 _tyr 111111111111111111111111111 _pro11111111111111111 _leu11111111111111111 _tyr 11111111111111111111111111 ?cit 1111111111111111111111111 _gly111111111 ?cit 1111111111111111111111111 ?cit 1111111111111111111112112 ?cit 22222222222 22222 2 2222 2 2 2 2 _gly22222222 2 _gly22222222 2 ?cit 22222222222"22222 2!2222#2$2"2" 2% ?edo2&2'2%2%2(2' 2) ?edo2*2+2)2)2,2+2- ?cit 2.2/202-2-2-2120222327212124232526242421282927272: ?cit 2;2<2=2:2:2:2>2=2?2@2D2>2>2A2@2B2C2A2A2>2E2F2D2D2G ?cit 2H2I2J2G2G2G2K2J2L2M2Q2K2K2N2M2O2P2N2N2K2R2S2Q2Q2T ?hoh2U ?hoh2V ?hoh2W ?hoh2X ?hoh2Y ?hoh2Z ?hoh2[ ?hoh2\ ?hoh2] ?hoh2^ ?hoh2_ ?hoh2` ?hoh2a ?hoh2b ?hoh 2c ?hoh!2d ?hoh"2e ?hoh#2f ?hoh$2g ?hoh%2h ?hoh&2i ?hoh'2j ?hoh(2k ?hoh)2l ?hoh*2m ?hoh+2n ?hoh,2o ?hoh-2p ?hoh.2q ?hoh/2r ?hoh02s ?hoh12t ?hoh22u ?hoh32v ?hoh42w ?hoh52x ?hoh62y ?hoh72z ?hoh82{ ?hoh92| ?hoh:2} ?hoh;2~ ?hoh<2 ?hoh=2 ?hoh>2 ?hoh?2 ?hoh@2 ?hohA2 ?hohB2 ?hohC2 ?hohD2 ?hohE2 ?hohF2 ?hohG2 ?hohH2 ?hohI2 ?hohJ2 ?hohK2 ?hohL2 ?hohM2 ?hohN2 ?hohO2 ?hohP2 ?hohQ2 ?hohR2 ?hohS2 ?hohT2 ?hohU2 ?hohV2 ?hohW2 ?hohX2 ?hohY2 ?hohZ2 ?hoh[2 ?hoh\2 ?hoh]2 ?hoh^2 ?hoh_2 ?hoh`2 ?hoha2 ?hohb2 ?hohc2 ?hohd2 ?hohe2 ?hohf2 ?hohg2 ?hohh2 ?hohi2 ?hohj2 ?hohk2 ?hohl2 ?hohm2 ?hohn2 ?hoho2 ?hohp2 ?hohq2 ?hohr2 ?hohs2 ?hoht2 ?hohu2 ?hohv2 ?hohw2 ?hohx2 ?hohy2 ?hohz2 ?hoh{2  ?hoh|2  ?hoh}2  ?hoh~2  ?hoh2  ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2" ?hoh2- ?hoh2/ ?hoh21 ?hoh24 ?hoh2; ?hoh2J ?hoh2K ?hoh2L ?hoh2S ?hoh2V ?hoh2] ?hoh2^ ?hoh2f ?hoh2i ?hoh2l ?hoh2p ?hoh2r ?hoh2w ?hoh2y ?hoh2} ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh2 ?hoh3 ?hoh3 ?hoh3 ?hoh3 ?hoh3 ?hoh3 ?hoh3 ?hoh3 ?hoh3 ?hoh3  ?hoh3  ?hoh3  ?hoh3  ?hoh3  ?hoh3" ?hoh3# ?hoh3$ ?hoh3% ?hoh3& ?hoh3' ?hoh3) ?hoh35 ?hoh36 ?hoh3A ?hoh3B ?hoh3F ?hoh3H ?hoh3K ?hoh3L ?hoh3P ?hoh3Q ?hoh3U ?hoh3 Z ?hoh3![ ?hoh3"] ?hoh3#a ?hoh3$e ?hoh3%i ?hoh3&j ?hoh3'l ?hoh3(q ?hoh3)v ?hoh3*w ?hoh3+x ?hoh3,{ ?hoh3- ?hoh3. ?hoh3/ ?hoh30 ?hoh31 ?hoh32 ?hoh33 ?hoh34 ?hoh35 ?hoh36 ?hoh37 ?hoh38 ?hoh39 ?hoh3: ?hoh3; ?hoh3< ?hoh3= ?hoh3> ?hoh3? 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